serine has been researched along with epidermal growth factor in 167 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (5.39) | 18.7374 |
| 1990's | 48 (28.74) | 18.2507 |
| 2000's | 77 (46.11) | 29.6817 |
| 2010's | 29 (17.37) | 24.3611 |
| 2020's | 4 (2.40) | 2.80 |
| Authors | Studies |
|---|---|
| Countaway, JL; Davis, RJ; Nairn, AC | 1 |
| Lentz, SR; Sadler, JE; Tsiang, M | 1 |
| Boynton, AL; Danesh, S; Kanemitsu, MY; Kurata, WE; Lau, AF | 1 |
| Park, D; Rhee, SG | 1 |
| Davis, RJ; Latour, DA; Raden, DL; Stanley, K; Theroux, SJ | 1 |
| Hunter, T; Meisenhelder, J | 1 |
| Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
| Chopra, DP; Mathieu, PA; Shoemaker, RL; Taylor, GW | 1 |
| McGivan, JD; Moule, SK | 1 |
| Hase, S; Ikenaka, T; Iwanaga, S; Kawabata, S; Nishimura, H | 1 |
| Countaway, JL; Davis, RJ; Gironès, N; McQuilkin, P | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Fiol, CJ; Gill, GN; Heisermann, GJ; Ingraham, HA; Walsh, BJ; Wiley, HS | 1 |
| Hase, S; Ikenaka, T; Iwanaga, S; Kawabata, S; Kisiel, W; Nishimura, H | 1 |
| Miyasaka, J; Miyasaka, T; Saltiel, AR | 1 |
| David-Pfeuty, T; Guesdon, F | 1 |
| Hase, S; Ikenaka, T; Iwanaga, S; Kawabata, S; Kisiel, W; Nishimura, H; Shimonishi, Y; Takao, T | 1 |
| Dobashi, K; Greene, MI; Weiner, DB | 1 |
| Liu, JF; Montelione, GT; Moy, FJ; Narang, SA; Ray, P; Scheraga, HA; Wu, R | 1 |
| Hunter, T; Isacke, CM; Trowbridge, IS | 1 |
| Cooper, JA; Hunter, T | 1 |
| Ennulat, DJ; Stach, BM; Stach, RW | 1 |
| Fox, CF; Rao, KV | 1 |
| Cobb, MH; Rosen, OM | 1 |
| Chambon, P; Endoh, H; Gotoh, Y; Kato, S; Kawashima, H; Kitamoto, T; Masuhiro, Y; Masushige, S; Metzger, D; Nishida, E; Sasaki, H; Uchiyama, S | 1 |
| Boonstra, J; Defize, LH; Schalkwijk, CG; Spaargaren, M; van den Bosch, H; Verkleij, AJ | 1 |
| Burgeson, RE; Gerecke, DR; Mayer, U; Pöschl, E; Timpl, R; Wagman, DW | 1 |
| Boonstra, J; van Bergen en Henegouwen, PM; van Delft, S; Verkleij, AJ | 1 |
| Campbell, JS; Dobrowolska, G; Eldar-Finkelman, H; Fischer, EH; Jensen, AM; Krebs, EG; Munar, ES; Reszka, AA; Seger, D; Seger, R | 1 |
| Arrandale, JM; Dannies, PS | 1 |
| Murray, AW; Oh, SY; Schmidt, SA | 1 |
| Decker, SJ; Pang, L; Saltiel, AR | 1 |
| Blenis, J; Chen, RH; Ginty, DD; Greenberg, ME; Miranti, CK; Misra, RP; Rivera, VM | 1 |
| Landreth, GE; Marshak, DR; Taylor, LK | 1 |
| Bos, JL; McGlade, J; Pawson, T; Pelicci, G; Pronk, GJ | 1 |
| Baldwin, GS; Burgess, AW; Ji, H; Moritz, RL; Simpson, RJ; Ward, LD | 1 |
| Dixon, JE; Guan, KL; Noh, SJ; Wu, X; Zhou, G | 1 |
| Briand, PA; Bunone, G; Miksicek, RJ; Picard, D | 1 |
| Adomeit, A; Boehmer, A; Boehmer, FD; Graness, A; Kovalenko, M; Liebmann, C; Nürnberg, B; Steinmetzer, T; Wetzker, R | 1 |
| Worley, PF; Yee, WM | 1 |
| Ku, NO; Omary, MB | 1 |
| Camp, HS; Tafuri, SR | 1 |
| Guroff, G; Hirata, Y; Katagiri, Y; Milbrandt, J | 1 |
| Downing, AK; Handford, PA; Smallridge, R; Whiteman, P; Winship, PR | 1 |
| Blenis, J; Fisher, TL; Joel, PB; Lannigan, DA; Smith, J; Sturgill, TW | 1 |
| Burt, JM; Cottrell, GT; Lau, AF; Warn-Cramer, BJ | 1 |
| Joel, PB; Lannigan, DA; Traish, AM | 1 |
| Bhatnagar, A; Chandra, A; Harter, TM; Petrash, JM; Srivastava, S; Srivastava, SK | 1 |
| De Cesare, D; Hanauer, A; Jacquot, S; Sassone-Corsi, P | 1 |
| Barnard, D; Clawson, D; Diaz, B; Marshall, M | 1 |
| Cooper, RG; Marais, R; Marshall, CJ; Mason, CS; Springer, CJ; Superti-Furga, G | 1 |
| Darimont, BD; Hammer, GD; Ingraham, HA; Krylova, I; Simpson, K; Weigel, NL; Zhang, Y | 1 |
| Feng, L; Liao, J; Omary, MB; Zhou, X | 1 |
| Facey, SL; Hertzberg, MS; Hogg, PJ | 1 |
| Cao, X; Jain, N; Kee, WH; Li, W; Zhang, T | 1 |
| Cao, X; Lim, CP | 1 |
| Campbell, DH; Daly, RJ; Sutherland, RL | 1 |
| Lesslauer, W; Mary, JL; Tomás-Zuber, M | 1 |
| Chittenden, T; Liu, Y; Lutz, RJ; Payne, G; Zhou, XM | 1 |
| Collins, MA; Graves, LM; He, Y; Kozlowski, P; Lee, JW; Sidovar, MF | 1 |
| Cohen, P; Lizcano, JM; Morrice, N | 1 |
| Birnbaum, MJ; Gaslightwala, I; Nakagawa, H; Okano, J; Rustgi, AK | 1 |
| Kleijn, M; Proud, CG | 1 |
| Chung, J; Kim, D; Kim, JW; Kim, S; Koh, H; Lee, KH | 1 |
| Kinuya, M; Mamiya, G; Takishima, K | 1 |
| Kolesnick, R; Xing, HR | 1 |
| Choi, SL; Choi, YK; Ha, J; Kang, I; Kim, J; Kim, SS; Kim, YS; Yoon, MY | 1 |
| Cordle, JJ; Downing, AK; Handford, PA; Knott, V; Smallridge, RS; Whiteman, P | 1 |
| Alessi, DR; Arthur, JS; Deak, M; Kieloch, A; Lain, S; Lizcano, JM; Morrice, N; Sapkota, GP; Williams, MR | 1 |
| Hurd, C; Rozengurt, E | 2 |
| Davie, JR; Strelkov, IS | 1 |
| Stepanova, VV; Tkachuk, VA | 1 |
| Darden, TA; Pedersen, LG; Perera, L | 1 |
| Brown, MC; Terfera, DR; Turner, CE | 1 |
| Huang, YT; Hwang, JJ; Ke, FC; Lee, LT; Lee, MT; Lee, PP; Liebow, C; Lo, TB; Schally, AV | 1 |
| Aaronson, D; Catling, AD; Christian, RE; Ficarro, SB; Gioeli, D; Hancock, M; Hunt, DF; Kwiek, JJ; Settlage, RE; Shabanowitz, J; Weber, MJ; White, FM | 1 |
| Paller, AS; Sun, P; Wang, XQ | 1 |
| Faivre, E; Horwitz, KB; Lange, CA; Olsen, A; Qiu, M | 1 |
| Acquaviva, C; Andermarcher, E; Bossis, G; Brockly, F; Ferrara, P; Jariel-Encontre, I; Piechaczyk, M | 1 |
| Abe, J; Akaike, M; Cameron, SJ; Lee, JD; Lerner-Marmarosh, N; Malik, S; Yan, C; Yang, J | 1 |
| Annis, DS; Hannah, BL; Misenheimer, TM; Mosher, DF | 1 |
| Andersen, JN; Barford, D; Hinks, JA; Meng, TC; Myers, MP; Salmeen, A; Tonks, NK | 1 |
| Blenis, J; Richards, SA; Roux, PP | 1 |
| Banan, A; Farhadi, A; Fields, JZ; Keshavarzian, A; Shaikh, M; Zhang, LJ | 2 |
| Ito, F; Takeuchi, K | 1 |
| Chung, KC; Yang, EJ; Yoon, JH | 1 |
| Berk, BC; Cavet, M; Yan, C; Yin, G; Zheng, Q | 1 |
| Blair, HC; Bodnar, RJ; Glading, A; Potter, DA; Reynolds, IJ; Satish, L; Shiraha, H; Wells, A | 1 |
| Blenis, J; Ohta, Y; Rabinovitz, I; Stossel, TP; Woo, MS | 1 |
| Mercurio, AM; Rabinovitz, I; Tsomo, L | 1 |
| Amachi, T; Kioka, N; Mitsushima, M; Suwa, A; Ueda, K | 1 |
| Barak, LS; Exum, ST; Freedman, NJ; Hildreth, KL; Kim, LK; Peppel, K; Wu, JH | 1 |
| Morinaga, N; Nakayama, K; Noda, M; Shin, HW | 1 |
| Faivre, E; Lange, CA; Skildum, A | 1 |
| Bryant, W; Rice, LW; Shupnik, MA; Snowhite, AE | 1 |
| Kyriakis, JM; Makkinje, A; Xu, D | 1 |
| Bhatnagar, S; Blankenship, KA; Brey, DM; Keynton, RS; Klinge, CM; Noisin, EL; Risinger, KE; Sumanasekera, WK; Zhao, L | 1 |
| Bode, AM; Cho, YY; Choi, BY; Choi, HS; Dong, Z; Zhu, F | 1 |
| Hong, JW; Lim, IK; Ryu, MS | 1 |
| Barr, FA; Lowe, M; Nakamura, N; Nakayama, K; Ohkuma, S; Yoshimura, S; Yoshioka, K | 1 |
| Bao, M; Clauser, K; Conley, PB; Hart, MJ; Komuves, L; Lin, H; Nanda, N; Phillips, DR; Quertermous, T | 1 |
| Arthur, SJ; Dyson, MH; Goto, H; Iborra, FJ; Inagaki, M; Mahadevan, LC; Nightingale, K; Thomson, S | 1 |
| Menard, RE; Qian, Z; Rosner, MR; Schade, GR; Trakul, N | 1 |
| Edin, ML; Juliano, RL | 1 |
| Cohen, MS; Shokat, KM; Taunton, J; Zhang, C | 1 |
| Bode, AM; Cho, YY; Choi, BY; Choi, HS; Dong, Z; Kang, BS; Mizuno, H | 1 |
| Manithody, C; Rezaie, AR; Yang, L | 1 |
| Avruch, J; Balan, K; Balan, V; Bronisz, A; Leicht, DT; Luo, Z; Qin, J; Sun, H; Tzivion, G; Zhu, J | 1 |
| Brunet, A; David-Dufilho, M; Millanvoye-Van Brussel, E; Rendu, F; Topal, G; Walch, L | 1 |
| Guo, J; Sheng, G; Warner, BW | 1 |
| Beeser, A; Chernoff, J; Hofmann, C; Jaffer, ZM | 1 |
| Garabedian, MJ; Ha, S; Huang, HY; Lee, P; Logan, SK; Melamed, J; Shapiro, E; Swenson, NK; Taneja, SS | 1 |
| Chang, JY; Jiang, C; Lu, BY | 1 |
| Kung, AL; Perry, A; Rubin, JB; Warrington, NM; Woerner, BM | 1 |
| Balan, K; Balan, V; Comb, MJ; Kaplun, A; Leicht, DT; Qin, J; Ruan, H; Singh-Gupta, V; Tzivion, G; Zhu, J | 1 |
| Fukushi, S; Kurane, I; Mizutani, T; Morikawa, S; Saijo, M | 1 |
| Berry, FB; Mirzayans, F; Walter, MA | 1 |
| Anest, V; Baldwin, AS; Cogswell, P; Duncan, EA | 1 |
| Bergh, S; de Groot, JF; Koul, D; Lafortune, TA; Lu, Y; Mills, GB; Shen, R; Sheng, X; Shishodia, S; Yung, WK | 1 |
| Adachi, S; Iwamoto, R; Mekada, E; Mizushima, H; Ohishi, M; Wang, X | 1 |
| Even-Faitelson, L; Ravid, S | 1 |
| Bode, AM; Cho, YY; Dong, Z; He, Z; Mizuno, H; Seok Choi, H; Tatsumi, Y | 1 |
| Hatano, N; Ihara, H; Kambe, T; Kume, K; Mizutani, A; Song, T; Sugimoto, K; Tokuda, M; Watanabe, Y; Yamaguchi, F | 1 |
| Jiang, X; Rozengurt, E; Sinnett-Smith, J | 1 |
| Chang, WC; Chen, YJ; Wang, YN | 1 |
| Band, H; Cook, SJ; Wiggins, CM | 1 |
| Barton, A; Hu, C; Humphrey, RG; Nelson, DM; Sadovsky, Y; Smith, SD; Sonnenberg-Hirche, C | 1 |
| French, FS; Gregory, CW; Ponguta, LA; Wilson, EM | 1 |
| André, J; Bernuau, D; Daniel, F; Güller, MC; Legrand, A; Mauviel, A; Setterblad, N; Verrecchia, F | 1 |
| Bode, AM; Cho, YY; Dong, Z; Lu, C; Pugliese, A; Tang, F; Yao, K; Zheng, D; Zhu, F | 1 |
| Kawanishi, M; Koizumi, K; Nishimura, M; Saiki, I; Sakurai, H; Shin, MS; Singhirunnusorn, P; Suzuki, S | 1 |
| Gerhard, R; Just, I; Olling, A; Schoentaube, J; Tatge, H | 1 |
| Acosta-Jaquez, HA; Ballif, BA; Carriere, A; Ekim, B; Fingar, DC; Foster, KG; Romeo, Y; Roux, PP; Soliman, GA | 1 |
| Ando, K; Fujino, T; Hayakawa, M; Oshima, T | 1 |
| Bae, YS; Jung, HY; Kim, J; Oh, H | 1 |
| Bode, AM; Dong, Z; Heo, YS; Kang, NJ; Lee, DE; Lee, HJ; Lee, KW; Seo, SK; Song, NR | 1 |
| Gill, SK; Needham, AJ; Ong, AC; Streets, AJ | 1 |
| Deng, Z; Du, WW; Lee, DY; Seth, A; Shan, SW; Shatseva, TA; Yang, BB; Yang, BL; Yee, AJ | 1 |
| Ammer, AG; Hayes, KE; Kelley, LC; Martin, KH; Weed, SA | 1 |
| Bode, AM; Cho, YY; Dong, Z; Lau, AT; Ma, WY; Peng, C; Yao, K; Zhang, J; Zheng, D; Zhu, F; Zykova, TA | 1 |
| Evans, AG; Levy, D; Zhang, Q; Zhong, Q; Zhong, S | 1 |
| Bode, AM; Cho, YY; Dong, Z; Kim, HG; Lau, AT; Lee, SY; Li, SQ; Xu, YM; Zhang, Z; Zheng, D; Zhu, F | 1 |
| Adachi, S; Hirose, Y; Itani, M; Kawaguchi, J; Kozawa, O; Moriwaki, H; Nakamura, M; Nakashima, M; Nishii, Y; Okano, Y; Shimizu, M; Yamauchi, T; Yasuda, I; Yoshioka, T | 1 |
| Bartke, A; Díaz, ME; González, L; Martínez, CS; Miquet, JG; Sotelo, AI; Turyn, D | 1 |
| Johansson, S; Riaz, A; Zeller, KS | 1 |
| Kitagawa, K; Kitagawa, M; Kotake, Y; Liu, N; Matsumoto, M; Nakanishi, M; Nakayama, KI; Niida, H; Shirasawa, S; Suzuki, S | 1 |
| Guo, W; Ren, J | 1 |
| Assiddiq, BF; Chan, SP; Chong, PK; Lim, YP; Tan, KY; Toy, W | 1 |
| Aldape, K; Bu, W; Cao, Y; Chiao, PJ; Cote, G; Koh, MY; Li, Y; Lu, Z; Verma, IM; Xia, Y; Yang, W; You, MJ; Zhang, L; Zheng, Y | 1 |
| Kerperien, J; Meijer, IM; Sotoca, AM; van Leeuwen, JE; van Zoelen, EJ | 1 |
| Wang, J; Yu, L; Zheng, X | 1 |
| Armbruster, N; Bell, GW; Cermeno, E; Dang, M; Hartmann, M; Herrlich, A; Lauffenburger, DA; Lodish, HF; Miller, MA; Root, DE | 1 |
| Choi, HW; Chung, KH; Huh, YH; Jun, CD; Kim, SH; Kwon, MS; Oh, S; Park, ZY; Rhee, S; Ryu, JH; Song, WK | 1 |
| Ishihama, Y; Kawasaki, Y; Saiki, I; Sakuma, T; Sakurai, H; Sugiyama, N; Tanaka, T; Yokoyama, S; Zhou, Y | 1 |
| Falk, MM; Fong, JT; Nimlamool, W | 1 |
| Kaito, Y; Kataoka, R; Mihara, T; Takechi, K; Tamura, M | 1 |
| Deng, X; Gao, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Yu, Y; Zhang, J; Zhao, Q; Zhu, J | 1 |
| Chaudhuri, R; Humphrey, SJ; James, DE; Ma, X; Parker, BL; Peterman, S; Yang, G | 1 |
| Hawke, DH; Lee, JH; Li, X; Lu, Z; Lyu, J; Qian, X; Wang, Y; Xia, Y; Zhang, G; Zheng, Y | 1 |
| Chen, T; Chou, PC; Hou, Y; Jiang, Y; Li, J; Xu, M; Yao, L; Zhang, W; Zhao, Q; Zhong, Y; Zhou, P | 1 |
| Haugsten, EM; Kostas, M; Szybowska, P; Wesche, J; Wiedlocha, A | 1 |
| Bian, X; Cai, J; Chen, C; Chen, H; Fan, Z; Fang, L; Ghesquière, B; Lan, P; Lee, MH; Li, K; Lu, W; Meng, M; Qin, B; Tang, Q; Wang, H; Wei, W; Wu, JL; Xing, F; Zhang, H; Zou, S | 1 |
| Chin, JM; Kato, M; Kimura, T; Kumagai, Y; Manevich, L; Okita, Y; Shinkai, Y; Suzuki, H; Wang, C; Zheng, L | 1 |
| An, S; Chauhan, KM; Jeon, M; Kyoung, M; Szeto, GL | 1 |
| Huang, X; Jin, H; Lee, MH; Li, X; Liu, Q; Liu, RY; Ma, N; Meng, X; Pan, Q; Peng, J; Wei, Y; Wen, W; Xiao, Y; Xie, X; Yu, F; Yu, H; Zhang, B; Zhang, J; Zhang, P | 1 |
3 review(s) available for serine and epidermal growth factor
| Article | Year |
|---|---|
Protein-tyrosine kinases.
Topics: Amino Acid Sequence; Animals; Binding Sites; Epidermal Growth Factor; ErbB Receptors; Humans; Lipid Metabolism; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Cell Surface; Retroviridae; Serine; Substrate Specificity; Threonine; Tyrosine; Viral Proteins | 1985 |
The insulin receptor and tyrosine protein kinase activity.
Topics: Adenosine Triphosphate; Animals; Avian Sarcoma Viruses; Cations, Divalent; Cell Membrane; Cell Transformation, Viral; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Insulin; Macromolecular Substances; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Serine; Substrate Specificity; Tyrosine | 1984 |
Urokinase as a multidomain protein and polyfunctional cell regulator.
Topics: Animals; Cell Adhesion; Epidermal Growth Factor; Humans; Models, Biological; Plasminogen; Protein Binding; Protein Structure, Tertiary; Serine; Signal Transduction; Urokinase-Type Plasminogen Activator | 2002 |
164 other study(ies) available for serine and epidermal growth factor
| Article | Year |
|---|---|
Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Molecular Sequence Data; Mutation; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Rabbits; Rats; Serine; Signal Transduction; Threonine; Tyrosine | 1992 |
Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Chromosome Deletion; Epidermal Growth Factor; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Protein Conformation; Receptors, Cell Surface; Receptors, Thrombin; Restriction Mapping; Serine; Threonine; Thrombin; Transfection | 1992 |
Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine.
Topics: Animals; Cell Communication; Cells, Cultured; Connexins; Epidermal Growth Factor; Intercellular Junctions; Liver; Membrane Proteins; Microscopy, Fluorescence; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Serine | 1992 |
Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Line; Chromatography, Affinity; Colforsin; Cyclic AMP; Epidermal Growth Factor; Immunoblotting; Kinetics; Molecular Sequence Data; Oncogene Proteins; Organ Specificity; PC12 Cells; Phosphorylation; Precipitin Tests; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Serine; Tetradecanoylphorbol Acetate; Threonine; Type C Phospholipases | 1992 |
Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; Substrate Specificity; Thymidine; Transfection; Tyrosine | 1992 |
The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cattle; Cell Division; Cell Line; Epidermal Growth Factor; Humans; Mice; Molecular Sequence Data; Oncogene Proteins; Peptide Mapping; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Rats; Sequence Homology, Amino Acid; Serine; Sulfhydryl Compounds; Type C Phospholipases; Tyrosine | 1992 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Characterization of epithelial cell cultures derived from human tracheal glands.
Topics: Carbohydrate Sequence; Cell Division; Cells, Cultured; Culture Techniques; Epidermal Growth Factor; Epithelial Cells; Epithelium; Exocrine Glands; Glucosamine; Humans; Hyaluronic Acid; Hydrocortisone; Insulin; Ion Channels; Kinetics; Membrane Potentials; Microscopy, Electron; Molecular Sequence Data; Mucins; Mucus; Pituitary Gland; Serine; Sulfates; Tissue Extracts; Trachea | 1991 |
Epidermal growth factor stimulates the phosphorylation of pyruvate kinase in freshly isolated rat hepatocytes.
Topics: Animals; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Liver; Phosphates; Phosphorylation; Pyruvate Kinase; Rats; Serine | 1991 |
The structure of (xylose)2glucose-O-serine 53 found in the first epidermal growth factor-like domain of bovine blood clotting factor IX.
Topics: Animals; Carbohydrate Conformation; Carbohydrate Sequence; Cattle; Chromatography, Gel; Epidermal Growth Factor; Factor IX; Glycoproteins; Molecular Sequence Data; Oligosaccharides; Serine | 1990 |
Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cell Line; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Peptide Fragments; Phosphopeptides; Phosphorylation; Plasmids; Platelet-Derived Growth Factor; Serine; Threonine; Thymidine | 1990 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Casein Kinases; Cell Line; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Kinetics; Ligands; Mice; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Oligopeptides; Phosphorylation; Protein Kinases; Restriction Mapping; Serine; Substrate Specificity; Threonine; Transcription, Genetic; Transfection | 1990 |
A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z.
Topics: Amino Acid Sequence; Animals; Blood Proteins; Carbohydrate Sequence; Cattle; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Factor IX; Factor VII; Humans; Models, Structural; Molecular Sequence Data; Oligosaccharides; Peptide Fragments; Protein Conformation; Sequence Homology, Nucleic Acid; Serine; Spectrometry, Mass, Fast Atom Bombardment | 1990 |
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; Ethers, Cyclic; Nerve Growth Factors; Okadaic Acid; Pheochromocytoma; Phosphorylation; Protein Kinases; Serine; Swine; Threonine; Tumor Cells, Cultured | 1990 |
Epidermal growth factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver.
Topics: Animals; Endopeptidases; Epidermal Growth Factor; Liver; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Serine; Serine Endopeptidases; Tyrosine | 1987 |
Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z.
Topics: Amino Acid Sequence; Animals; Blood Proteins; Carbohydrate Sequence; Cattle; Disaccharides; Epidermal Growth Factor; Factor IX; Factor VII; Glycosylation; Humans; Mass Spectrometry; Molecular Sequence Data; Oligopeptides; Serine; Trisaccharides | 1989 |
Differential regulation of oncogenic and cellular p185 by serine/threonine kinases.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Membrane Proteins; Mutation; Oncogene Proteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Serine; Tetradecanoylphorbol Acetate; Threonine | 1989 |
Structure-function studies of murine epidermal growth factor: expression and site-directed mutagenesis of epidermal growth factor gene.
Topics: Amino Acid Sequence; Amino Acids; Animals; Base Sequence; Binding, Competitive; Blotting, Western; Cell Line, Transformed; Cell Membrane; Cloning, Molecular; DNA Restriction Enzymes; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Gene Expression Regulation; Leucine; Mice; Molecular Sequence Data; Mutation; Recombinant Proteins; Serine; Structure-Activity Relationship; Valine | 1988 |
Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies.
Topics: Annexins; Antibodies, Monoclonal; Cell Transformation, Viral; Epidermal Growth Factor; Humans; Membrane Proteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Retroviridae Proteins; Serine; Tyrosine | 1986 |
Phenylmethylsulfonyl fluoride (PMSF) inhibits nerve growth factor binding to the high affinity (type I) nerve growth factor receptor.
Topics: Animals; Chick Embryo; Dithionitrobenzoic Acid; Epidermal Growth Factor; ErbB Receptors; Ganglia, Spinal; In Vitro Techniques; Kinetics; Phenylmethylsulfonyl Fluoride; Receptors, Cell Surface; Serine; Solubility; Sulfones | 1986 |
Epidermal growth factor stimulates tyrosine phosphorylation of human glucocorticoid receptor in cultured cells.
Topics: Breast; Cell Line; Dexamethasone; Epidermal Growth Factor; Female; Humans; Phosphorylation; Receptors, Glucocorticoid; Serine; Tyrosine | 1987 |
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Humans; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; Phosphorylation; Polyunsaturated Alkamides; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Receptors, Estrogen; Recombinant Fusion Proteins; Serine; Somatomedins; Tamoxifen; Transcriptional Activation; Transfection | 1995 |
Epidermal growth factor (EGF) induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic phospholipase A2.
Topics: 3T3 Cells; Animals; Biological Transport; Calcium; Cell Membrane; Cytosol; Enzyme Activation; Epidermal Growth Factor; Mice; Phospholipases A; Phospholipases A2; Phosphorylation; Serine | 1995 |
Low nidogen affinity of laminin-5 can be attributed to two serine residues in EGF-like motif gamma 2III4.
Topics: Amino Acid Sequence; Asparagine; Base Sequence; Basement Membrane; Binding Sites; Cell Adhesion Molecules; Cell Line; DNA Primers; Epidermal Growth Factor; Humans; Kalinin; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Transfection; Valine | 1995 |
Epidermal growth factor induces serine phosphorylation of actin.
Topics: 3T3 Cells; Actins; Animals; Epidermal Growth Factor; Mice; Phosphorylation; Serine | 1995 |
Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biological Transport; Cell Compartmentation; Cell Division; Dose-Response Relationship, Drug; Epidermal Growth Factor; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Conformation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Inhibition of rat prolactin (PRL) storage by coexpression of human PRL.
Topics: Animals; Asparagine; Biological Transport; Cell Compartmentation; Cytoplasmic Granules; Epidermal Growth Factor; Estradiol; Gene Expression; Humans; Insulin; Models, Molecular; Pituitary Neoplasms; Prolactin; Protein Conformation; Rats; Recombinant Fusion Proteins; Serine; Species Specificity; Transfection; Tumor Cells, Cultured | 1994 |
Epidermal growth factor inhibits gap junctional communication and stimulates serine-phosphorylation of connexin43 in WB cells by a protein kinase C-independent mechanism.
Topics: Animals; Cell Communication; Cell Line; Connexin 43; Epidermal Growth Factor; Gap Junctions; Phosphorylation; Protein Kinase C; Rats; Serine | 1993 |
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphorylation; Protein Kinase C; Protein Kinases; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1993 |
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
Topics: 3T3 Cells; Animals; Antibodies; Base Sequence; Binding Sites; Cell Line; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Humans; Kinetics; Mice; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Serine; Serum Response Factor; Signal Transduction; Transcriptional Activation | 1993 |
Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Ligands; Molecular Sequence Data; Nerve Growth Factors; PC12 Cells; Peptide Fragments; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction | 1993 |
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Mice; Phosphorylation; Proteins; Receptor, Insulin; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1993 |
Epidermal growth factor induces serine phosphorylation of stathmin in a human colon carcinoma cell line (LIM 1215).
Topics: Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; Microtubule Proteins; Molecular Sequence Data; Oligonucleotides, Antisense; Peptide Mapping; Phosphoproteins; Phosphorylation; Serine; Stathmin; Tumor Cells, Cultured; Tyrosine | 1993 |
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.
Topics: Cloning, Molecular; Enzyme Activation; Epidermal Growth Factor; HeLa Cells; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Substrate Specificity | 1996 |
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.
Topics: Epidermal Growth Factor; HeLa Cells; Humans; Phosphorylation; Protein Kinases; Receptors, Estrogen; Serine; Signal Transduction; Trans-Activators; Tumor Cells, Cultured | 1996 |
Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor.
Topics: Adenylyl Cyclases; Bradykinin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Humans; Isoproterenol; Oncogene Proteins; Phosphorylation; Serine; Threonine; Tumor Cells, Cultured; Tyrosine | 1996 |
Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Asparagine; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Growth Substances; GTP-Binding Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Nerve Growth Factors; Neurites; Neuropeptides; Oncogene Protein p21(ras); PC12 Cells; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Ras Homolog Enriched in Brain Protein; Rats; Recombinant Proteins; Serine; Signal Transduction | 1997 |
Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.
Topics: Animals; Cell Line; Cricetinae; Epidermal Growth Factor; Humans; Keratins; Phosphorylation; Serine | 1997 |
Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; DNA Primers; DNA-Binding Proteins; Epidermal Growth Factor; Genes, Reporter; Humans; Mice; Microbodies; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Point Mutation; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Transcription Factors; Transcription, Genetic; Transfection | 1997 |
Differential regulation of the transcriptional activity of the orphan nuclear receptor NGFI-B by membrane depolarization and nerve growth factor.
Topics: Animals; Binding Sites; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Mutagenesis, Site-Directed; Nerve Growth Factors; Nuclear Receptor Subfamily 4, Group A, Member 1; PC12 Cells; Phosphorylation; Potassium Chloride; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Proteins; Serine; Transcription Factors; Transcriptional Activation | 1997 |
A Gly --> Ser change causes defective folding in vitro of calcium-binding epidermal growth factor-like domains from factor IX and fibrillin-1.
Topics: Amino Acid Substitution; Epidermal Growth Factor; Factor IX; Fibrillin-1; Fibrillins; Glycine; Humans; Microfilament Proteins; Mutation; Protein Folding; Serine | 1998 |
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.
Topics: Animals; Catalysis; Chromosomal Proteins, Non-Histone; COS Cells; Cricetinae; DNA-Binding Proteins; Epidermal Growth Factor; Furylfuramide; Histone Chaperones; Humans; Leucine Zippers; Phosphorylation; Protein Kinases; Receptors, Estrogen; Receptors, Interferon; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
Topics: Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cell Line; Connexin 43; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gap Junctions; HeLa Cells; Humans; Kinetics; Lysophospholipids; Mice; Mice, Knockout; Models, Biological; Phosphorylation; Rats; Recombinant Proteins; Serine; Signal Transduction; Transfection | 1998 |
Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Estradiol; Humans; Mammary Glands, Animal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Receptors, Estrogen; Serine; Tetradecanoylphorbol Acetate | 1998 |
Kinetic studies of FR-1, a growth factor-inducible aldo-keto reductase.
Topics: Aldehyde Reductase; Aldehydes; Amino Acid Substitution; Animals; Binding Sites; Cysteine; Enzyme Activation; Epidermal Growth Factor; Growth Substances; Kinetics; Mass Spectrometry; Mice; Mutagenesis, Site-Directed; Protein Biosynthesis; Proteins; Serine; Substrate Specificity | 1998 |
Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.
Topics: Cell Line; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Epidermal Growth Factor; ets-Domain Protein Elk-1; Gene Expression Regulation; Genes, fos; Humans; Isoenzymes; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Transcription Factors; Transcription, Genetic | 1998 |
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression Regulation; Guanosine Triphosphate; Molecular Sequence Data; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Topics: Animals; Cell Membrane; COS Cells; Epidermal Growth Factor; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Epidermal Growth Factor; Fushi Tarazu Transcription Factors; Genes, Reporter; Homeodomain Proteins; Humans; Mutation; Nuclear Proteins; Nuclear Receptor Co-Repressor 2; Nuclear Receptor Coactivator 2; Phosphorylation; Protein Processing, Post-Translational; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Reproduction; Serine; Signal Transduction; Steroidogenic Factor 1; Stress, Physiological; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1999 |
Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinase-dependent pathway.
Topics: Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colon; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Keratins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Serine; Signal Transduction; Solubility; Tyrosine; Vanadates | 1999 |
An Arg/Ser substitution in the second epidermal growth factor-like module of factor IX introduces an O-linked carbohydrate and markedly impairs activation by factor XIa and factor VIIa/Tissue factor and catalytic efficiency of factor IXa.
Topics: Amino Acid Substitution; Arginine; Blood Coagulation; Carbohydrates; Catalysis; Epidermal Growth Factor; Factor IX; Factor VIIa; Factor XIa; Humans; Point Mutation; Serine; Thromboplastin | 1999 |
Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Humans; Interleukin-6; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Kinase C; Serine; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation | 1999 |
Serine phosphorylation and negative regulation of Stat3 by JNK.
Topics: Amino Acid Substitution; Animals; COS Cells; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Point Mutation; Pyridines; Recombinant Fusion Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transfection; Ultraviolet Rays | 1999 |
Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.
Topics: Cell Adhesion; Cells, Cultured; Cortactin; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Microfilament Proteins; Neoplasm Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Serine; src Homology Domains; Structure-Activity Relationship; Threonine | 1999 |
Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.
Topics: Amino Acid Sequence; Catalytic Domain; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; Indoles; Insulin; Ionomycin; Isoquinolines; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Substrate Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha | 2000 |
Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.
Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Binding Sites; Carrier Proteins; Cell Death; Cell Line; Cell Survival; COS Cells; Cyclic AMP-Dependent Protein Kinases; Dimerization; Epidermal Growth Factor; Growth Substances; HeLa Cells; Humans; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-bcl-2; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Transfection | 2000 |
Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase.
Topics: Catalytic Domain; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Humans; Liver; MAP Kinase Signaling System; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine | 2000 |
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
Topics: 14-3-3 Proteins; Animals; Antibodies; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Cells, Cultured; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Serine; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2000 |
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.
Topics: Androstadienes; Blotting, Southern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dimerization; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Esophageal Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Ligands; Morpholines; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
The activation of eukaryotic initiation factor (eIF)2B by growth factors in PC12 cells requires MEK/ERK signalling.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Epidermal Growth Factor; Eukaryotic Initiation Factor-2B; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Kinetics; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; PC12 Cells; Phosphorylation; Rats; Serine; Signal Transduction | 2000 |
Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.
Topics: Animals; Apoptosis; Caspases; Cell Line; Epidermal Growth Factor; Humans; Hydrolysis; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Threonine; Tumor Necrosis Factor-alpha; Two-Hybrid System Techniques | 2000 |
Detection of kinases that phosphorylate 14-3-3 binding sites of Raf-1 using in situ gel kinase assay.
Topics: Animals; Autoradiography; Binding Sites; Cells, Cultured; Epidermal Growth Factor; Gels; Glutathione Transferase; Humans; Mice; Mutation; Phosphorylase Kinase; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Serine | 2000 |
Kinase suppressor of Ras signals through Thr269 of c-Raf-1.
Topics: Animals; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Humans; Mice; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Proteins; Serine; Signal Transduction; Threonine; Transfection; Tyrosine; Valine | 2001 |
Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway.
Topics: 3T3 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Catalysis; Cell Line; Colforsin; COS Cells; DNA; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Ribonucleotides; RNA; RNA, Antisense; Serine; Signal Transduction; Time Factors; Transfection | 2001 |
A G1127S change in calcium-binding epidermal growth factor-like domain 13 of human fibrillin-1 causes short range conformational effects.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Calcium; Cloning, Molecular; Conserved Sequence; Epidermal Growth Factor; Extracellular Matrix Proteins; Fibrillin-1; Fibrillins; Genetic Variation; Glycine; Humans; Marfan Syndrome; Microfilament Proteins; Models, Molecular; Molecular Sequence Data; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Serine | 2001 |
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cysteine; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Glutathione Transferase; Humans; Immunoblotting; Isoquinolines; Mevalonic Acid; Mice; Models, Biological; Mutation; Peutz-Jeghers Syndrome; Phosphorylation; Precipitin Tests; Protein Prenylation; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Time Factors; Transfection | 2001 |
Protein kinase D is sufficient to suppress EGF-induced c-Jun Ser 63 phosphorylation.
Topics: Animals; Cell Line; COS Cells; Ecdysone; Epidermal Growth Factor; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Serine; Transfection | 2001 |
Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblasts.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Histones; MAP Kinase Signaling System; Mice; Phosphorylation; ras Proteins; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 2002 |
Predicted solution structure of zymogen human coagulation FVII.
Topics: Binding Sites; Calcium; Crystallography, X-Ray; Electrochemistry; Epidermal Growth Factor; Factor VII; Factor VIIa; Humans; Models, Molecular; Peptide Fragments; Protein Conformation; Serine; Serine Endopeptidases; Structure-Activity Relationship; Thromboplastin | 2002 |
Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells.
Topics: Actins; Animals; Cell Adhesion; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Epidermal Growth Factor; Kidney; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Reference Values; Serine; Threonine | 2002 |
Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis-associated properties in human epidermoid carcinoma A431 cells.
Topics: Antineoplastic Agents, Hormonal; Carcinoma, Squamous Cell; Caspases; Cell Division; DNA Fragmentation; Enzyme Activation; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Humans; Immunoblotting; Matrix Metalloproteinases; Neoplasm Invasiveness; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Serine; Threonine; Time Factors; Triptorelin Pamoate; Tumor Cells, Cultured | 2002 |
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, Affinity; Colforsin; COS Cells; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Ligands; Male; MAP Kinase Signaling System; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Phosphopeptides; Phosphorylation; Plasmids; Prostatic Neoplasms; Protein Kinase C; Receptors, Androgen; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured | 2002 |
Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor.
Topics: Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cytoplasm; Detergents; Dimerization; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Immunoblotting; Keratinocytes; Models, Chemical; Oligonucleotides, Antisense; Phosphorylation; Precipitin Tests; Protein Binding; Serine; Signal Transduction; Tyrosine; Up-Regulation | 2002 |
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Breast Neoplasms; Butadienes; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Epidermal Growth Factor; Fatty Acids, Unsaturated; Humans; Ligands; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Mutation; Nitriles; Phosphorylation; Promegestone; Proteasome Endopeptidase Complex; Receptors, Progesterone; Serine; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression.
Topics: Animals; Cell Division; Cells, Cultured; Cysteine Endopeptidases; Embryo, Mammalian; Epidermal Growth Factor; Fibroblasts; G1 Phase; Gene Expression Regulation; Genes, Reporter; Half-Life; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Proto-Oncogene Proteins c-fos; Rats; Recombinant Proteins; Sequence Deletion; Serine | 2003 |
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.
Topics: Blotting, Western; Cell Line; Connexin 43; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gap Junctions; Genes, Dominant; Humans; Immunoblotting; MAP Kinase Kinase 1; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection | 2003 |
A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats.
Topics: Calcium; Circular Dichroism; Cloning, Molecular; Coronary Disease; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Humans; Polymorphism, Genetic; Protein Binding; Protein Conformation; Protein Denaturation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Temperature; Thrombospondin 1; Tryptophan; Ultraviolet Rays | 2003 |
Uncoupling of protein kinase D from suppression of EGF-dependent c-Jun phosphorylation in cancer cells.
Topics: Ecdysterone; Epidermal Growth Factor; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Serine; Signal Transduction; Tumor Cells, Cultured | 2003 |
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.
Topics: Amides; Amino Acid Substitution; Binding Sites; Cysteine; Epidermal Growth Factor; Insulin; Models, Molecular; Oxidation-Reduction; Phosphorylation; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Serine; Sulfenic Acids | 2003 |
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.
Topics: Amino Acid Sequence; Binding Sites; Cells, Cultured; Epidermal Growth Factor; Extracellular Matrix; Humans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Molecular Sequence Data; Mutation; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sequence Homology, Amino Acid; Serine; Signal Transduction | 2003 |
Zeta isoform of protein kinase C prevents oxidant-induced nuclear factor-kappaB activation and I-kappaBalpha degradation: a fundamental mechanism for epidermal growth factor protection of the microtubule cytoskeleton and intestinal barrier integrity.
Topics: Active Transport, Cell Nucleus; Caco-2 Cells; Cytoskeleton; Cytosol; Epidermal Growth Factor; Humans; Hydrogen Peroxide; I-kappa B Proteins; Intestines; Microtubules; NF-kappa B; Oligodeoxyribonucleotides, Antisense; Oxidants; Phosphorylation; Protein Kinase C; Serine; Transfection; Tubulin | 2003 |
Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biotin; Caspase 9; Caspases; Cell Line; Cell Line, Tumor; Cell Membrane; Chromones; DNA Fragmentation; Down-Regulation; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Immunoblotting; Inositol; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Recombinant Proteins; Serine; Signal Transduction; Threonine; Time Factors | 2004 |
Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Hippocampus; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Response Elements; RNA, Small Interfering; Serine; Signal Transduction; Stem Cells | 2004 |
PKC-beta1 isoform activation is required for EGF-induced NF-kappaB inactivation and IkappaBalpha stabilization and protection of F-actin assembly and barrier function in enterocyte monolayers.
Topics: Actins; Caco-2 Cells; Cell Nucleus; Cytoskeleton; Cytosol; Enterocytes; Epidermal Growth Factor; Humans; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Oligodeoxyribonucleotides, Antisense; Oxidative Stress; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Serine; Transfection | 2004 |
14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.
Topics: 14-3-3 Proteins; Animals; COS Cells; Enzyme Activation; Epidermal Growth Factor; HeLa Cells; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Serine; Tyrosine 3-Monooxygenase | 2004 |
Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation.
Topics: Amino Acid Substitution; Animals; Base Sequence; Binding Sites; Calcium; Calpain; Cell Line; Cell Movement; DNA, Complementary; Enzyme Activation; Epidermal Growth Factor; Humans; In Vitro Techniques; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Recombinant Proteins; Serine | 2004 |
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.
Topics: Amino Acid Sequence; Animals; Butadienes; Cell Line, Tumor; Cell Movement; Colforsin; Contractile Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Filamins; Humans; MAP Kinase Signaling System; Melanoma; Microfilament Proteins; Molecular Sequence Data; Nitriles; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases; Sequence Alignment; Serine | 2004 |
Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; COS Cells; Epidermal Growth Factor; Hemidesmosomes; Humans; Integrin beta4; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Recombinant Proteins; Serine; Transfection | 2004 |
Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cytosol; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibronectins; Gene Deletion; Glutathione Transferase; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Luminescent Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Proteins; Mutagenesis, Site-Directed; NIH 3T3 Cells; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Serine; src Homology Domains; Time Factors; Transfection | 2004 |
Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.
Topics: Animals; beta-Adrenergic Receptor Kinases; Cattle; Cell Line; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Fibroblasts; G-Protein-Coupled Receptor Kinase 3; Humans; Mice; Phosphoproteins; Phosphorylation; Protein Binding; Receptor, Platelet-Derived Growth Factor beta; Serine; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection | 2004 |
BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.
Topics: ADP-Ribosylation Factors; Cell Membrane; Endosomes; Epidermal Growth Factor; Gene Expression; Glutamic Acid; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Mutation; Protein Binding; rab GTP-Binding Proteins; rab4 GTP-Binding Proteins; Serine; Shiga Toxin 1 | 2004 |
Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases.
Topics: Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Cyclin D1; Disease Progression; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Luciferases; MAP Kinase Signaling System; Mifepristone; Phosphorylation; Point Mutation; Progestins; Receptors, Progesterone; S Phase; Serine; Time Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2005 |
The estrogen receptor (ER)alpha variant Delta5 exhibits dominant positive activity on ER-regulated promoters in endometrial carcinoma cells.
Topics: Cell Line, Tumor; Dimerization; Endometrial Neoplasms; Epidermal Growth Factor; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Ligands; Mutagenesis, Site-Directed; Nuclear Proteins; Promoter Regions, Genetic; Selective Estrogen Receptor Modulators; Serine; Uterus | 2005 |
Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function.
Topics: Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acid Sequence; Animals; Blotting, Northern; Blotting, Western; Carrier Proteins; Cell Line; Dexamethasone; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glucocorticoids; Glutathione Transferase; Guanosine Triphosphate; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Models, Genetic; Molecular Sequence Data; Oligonucleotides; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Structure, Tertiary; Rats; RNA Interference; RNA, Double-Stranded; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Proteins | 2005 |
Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.
Topics: Angiogenesis Inhibitors; Animals; Aorta; Blotting, Western; Cattle; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Flavonoids; Fulvestrant; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Microcirculation; Models, Biological; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenols; Phosphorylation; Polyphenols; Resveratrol; Serine; Signal Transduction; Stilbenes; Tamoxifen; Time Factors; Transfection; Umbilical Veins; Wine | 2005 |
Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.
Topics: Amino Acid Sequence; Animals; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Genes, Reporter; Histones; Humans; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Phosphorylation; Pyridines; Serine; Two-Hybrid System Techniques; Ultraviolet Rays | 2005 |
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.
Topics: Antibodies; Apoptosis; Cell Death; Cell Proliferation; Cyclin B; Cyclin B1; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Genes, Tumor Suppressor; Genetic Vectors; Glutathione Transferase; Humans; Immediate-Early Proteins; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Microscopy, Fluorescence; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitosis; Models, Biological; Mutation; NIMA-Interacting Peptidylprolyl Isomerase; Open Reading Frames; p38 Mitogen-Activated Protein Kinases; Peptidylprolyl Isomerase; Phosphorylation; Protein Binding; Recombinant Proteins; RNA Interference; Serine; Time Factors; Transfection; Tumor Suppressor Proteins; U937 Cells | 2005 |
Convergence of cell cycle regulation and growth factor signals on GRASP65.
Topics: Amino Acid Sequence; Animals; Binding Sites; CDC2 Protein Kinase; Cell Cycle; Cell Line; COS Cells; Cytosol; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Golgi Apparatus; Golgi Matrix Proteins; HeLa Cells; Humans; Interphase; Liver; Membrane Proteins; Microscopy, Confocal; Mitosis; Molecular Sequence Data; Mutation; Peptides; Phosphorylation; Protein Structure, Tertiary; Rats; S Phase; Serine; Signal Transduction; Time Factors | 2005 |
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.
Topics: Amino Acid Sequence; Animals; Biotin; Blood Platelets; Blotting, Western; Cell Communication; Cell Line; Cloning, Molecular; COS Cells; Cross-Linking Reagents; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Epidermal Growth Factor; Eptifibatide; Flow Cytometry; Humans; Immunoprecipitation; Mass Spectrometry; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Peptides; Peroxidase; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Signal Transduction; Threonine; Tissue Distribution; Transfection; Tyrosine | 2005 |
MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.
Topics: Acetylation; Animals; Anisomycin; Cell Line; Cell Nucleus; Chromatin; Epidermal Growth Factor; Histones; Hydroxamic Acids; Interphase; Mice; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 8; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Transfection | 2005 |
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Topics: Animals; Aspartic Acid; Cell Line; Cell Membrane; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hippocampus; Humans; Immunoprecipitation; MAP Kinase Signaling System; Models, Biological; Mutation; Neurons; Phosphatidylethanolamine Binding Protein; Phosphorylation; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Rats; RNA; RNA, Small Interfering; Serine; Signal Transduction; Time Factors; Tyrosine | 2005 |
Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.
Topics: Animals; Cell Adhesion; Cell Line; Cell Membrane; Enzyme Activation; Epidermal Growth Factor; Extracellular Matrix; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-raf; RNA, Small Interfering; Serine; Signal Transduction | 2005 |
Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
Topics: Amino Acid Sequence; Animals; Binding Sites; Computational Biology; COS Cells; Cysteine; Cytidine Deaminase; Enzyme Inhibitors; Epidermal Growth Factor; Heterocyclic Compounds, 2-Ring; Histones; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Mutation; Phosphorylation; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; Sequence Alignment; Serine; Structure-Activity Relationship; Threonine | 2005 |
Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Epidermal Growth Factor; Epithelial Cells; Gene Expression Regulation; Genes, fos; Genes, jun; Histones; Mice; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; RNA, Small Interfering; Serine; Transcription Factor AP-1 | 2005 |
Identification of factor Xa residues critical for interaction with protein Z-dependent protease inhibitor: both active site and exosite interactions are required for inhibition.
Topics: Alanine; Animals; Arginine; Binding Sites; Binding, Competitive; Catalysis; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Factor Xa; Heparin; Humans; Kinetics; Lipoproteins; Lysine; Models, Biological; Mutagenesis; Mutation; Phospholipids; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serpins | 2005 |
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Epidermal Growth Factor; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Mass Spectrometry; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; Phosphorylation; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Serine | 2005 |
Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.
Topics: Atherosclerosis; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Humans; Inflammation; Models, Biological; Mutation; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Receptor, PAR-1; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; src-Family Kinases; Threonine; Thrombin; Thrombomodulin; Time Factors; Tyrosine; Umbilical Veins | 2005 |
Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase 4; Detergents; Epidermal Growth Factor; Epithelial Cells; Flow Cytometry; G1 Phase; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Immunoprecipitation; Intestine, Small; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Rats; Retinoblastoma Protein; S Phase; Serine; Stem Cells | 2005 |
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.
Topics: Adenoviridae; Animals; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; HeLa Cells; Humans; Immunoblotting; MAP Kinase Kinase 1; Mice; NIH 3T3 Cells; p21-Activated Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; RNA, Small Interfering; Serine; Signal Transduction | 2005 |
Cell-specific regulation of androgen receptor phosphorylation in vivo.
Topics: Amino Acid Sequence; Antibody Specificity; Cell Division; Cell Line; Chromones; Dihydrotestosterone; Embryo, Mammalian; Epidermal Growth Factor; Epithelial Cells; Fetus; Fluorescent Antibody Technique; Homeostasis; Humans; Immunoblotting; Immunohistochemistry; Insulin-Like Growth Factor I; Ki-67 Antigen; Kidney; Male; Metribolone; Molecular Sequence Data; Morpholines; Mutation; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostate; Protein Kinases; Receptors, Androgen; Serine; Stromal Cells; Structure-Activity Relationship; Transcription, Genetic; Transfection | 2005 |
Isomers of epidermal growth factor with Ser --> Cys mutation at the N-terminal sequence: isomerization, stability, unfolding, refolding, and structure.
Topics: Amino Acid Sequence; Cysteine; Disulfides; Epidermal Growth Factor; Humans; Isomerism; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Serine | 2005 |
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies.
Topics: Animals; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Chemokine CXCL12; Chemokines, CXC; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Humans; Microglia; Peptide Fragments; Phosphorylation; Protein Kinase C; Rabbits; Receptors, CXCR4; Serine; Transcriptional Activation | 2005 |
Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase.
Topics: Amino Acid Sequence; Animals; Antibodies, Phospho-Specific; Cells, Cultured; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Gene Expression; MAP Kinase Kinase Kinases; Molecular Sequence Data; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine | 2006 |
Regulation of p90RSK phosphorylation by SARS-CoV infection in Vero E6 cells.
Topics: Animals; Chlorocebus aethiops; Epidermal Growth Factor; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Signal Transduction; Threonine; Vero Cells | 2006 |
Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade.
Topics: Amino Acid Sequence; Cycloheximide; DNA, Complementary; Epidermal Growth Factor; Forkhead Transcription Factors; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Genes, Reporter; HeLa Cells; Humans; Immunoblotting; Luciferases; MAP Kinase Signaling System; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Serine; Signal Transduction; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Ubiquitin | 2006 |
The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.
Topics: Animals; Cyclic AMP; Epidermal Growth Factor; Fibroblasts; Histones; I-kappa B Proteins; Mice; NF-KappaB Inhibitor alpha; Phosphorylation; Promoter Regions, Genetic; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tumor Necrosis Factor-alpha | 2006 |
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Topics: Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Central Nervous System Neoplasms; Enzyme Activation; Epidermal Growth Factor; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 4 or More Rings; Humans; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Tetrazoles | 2006 |
Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.
Topics: Alanine; Amino Acid Sequence; Animals; Anisomycin; Cell Line; Chlorocebus aethiops; Cytoplasm; Epidermal Growth Factor; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ionophores; Lysophospholipids; Male; Mice; Mice, Nude; Molecular Sequence Data; Mutation; Neoplasms, Experimental; Peptide Fragments; Phosphorylation; Protein Structure, Tertiary; Serine; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Vero Cells | 2006 |
PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly.
Topics: Actin Cytoskeleton; Amino Acid Sequence; Cytoskeleton; Epidermal Growth Factor; Humans; Immunoprecipitation; Molecular Sequence Data; Mutation; Nonmuscle Myosin Type IIB; p21-Activated Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Tumor Cells, Cultured | 2006 |
Involvement of the paxillin pathway in JB6 Cl41 cell transformation.
Topics: Animals; Base Sequence; Cell Growth Processes; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Epidermal Growth Factor; MAP Kinase Kinase 4; Mice; Molecular Sequence Data; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Serine; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2006 |
p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.
Topics: Amino Acid Sequence; Animals; Cerebellum; Epidermal Growth Factor; Hippocampus; Neurons; Nitric Oxide Synthase Type I; Phosphorylation; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Serine | 2007 |
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.
Topics: Angiotensins; Animals; Carbachol; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intestinal Mucosa; Ionomycin; Kinetics; Lysophospholipids; Phosphorylation; Protein Kinase C; Rats; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Tyrosine | 2007 |
ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.
Topics: Cells, Cultured; E1A-Associated p300 Protein; Epidermal Growth Factor; Gene Expression Regulation; Humans; Keratin-16; Mitogen-Activated Protein Kinase 1; Phosphorylation; Promoter Regions, Genetic; Serine | 2007 |
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblasts; Humans; Membrane Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Serine; Tamoxifen; Tyrosine; Ubiquitin; Vanadates | 2007 |
Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of BAD Serine 112.
Topics: Apoptosis; bcl-Associated Death Protein; Cell Hypoxia; Cells, Cultured; Epidermal Growth Factor; Female; Green Fluorescent Proteins; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Protein Binding; Recombinant Fusion Proteins; Serine; Signal Transduction; Transfection; Trophoblasts | 2008 |
Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer.
Topics: Animals; Cell Line; Cell Nucleus; Chlorocebus aethiops; Dependovirus; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Transplantation; Phosphorylation; Prostatic Neoplasms; Receptors, Androgen; Recurrence; Serine | 2008 |
c-Fos accelerates hepatocyte conversion to a fibroblastoid phenotype through ERK-mediated upregulation of paxillin-Serine178 phosphorylation.
Topics: Base Sequence; Cell Line, Transformed; DNA Primers; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hepatocytes; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Paxillin; Phosphorylation; Polymerase Chain Reaction; Proto-Oncogene Proteins c-fos; Serine; Signal Transduction; Transforming Growth Factor beta; Up-Regulation | 2009 |
Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.
Topics: Animals; Cell Adhesion; Cell Growth Processes; Cell Line; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 3; Cyclin-Dependent Kinases; Epidermal Growth Factor; Humans; Mice; NIH 3T3 Cells; Phosphorylation; Proto-Oncogene Proteins c-jun; Serine; Signal Transduction; Transcription Factor AP-1; Transfection | 2009 |
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha | 2009 |
Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A.
Topics: Bacterial Toxins; Caco-2 Cells; cdc42 GTP-Binding Protein; Clostridioides difficile; Enterocolitis, Pseudomembranous; Enterotoxins; Epidermal Growth Factor; Host-Pathogen Interactions; Humans; Intestines; Phosphorylation; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Serine; Substrate Specificity; Virulence | 2009 |
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Carrier Proteins; Cell Line; Epidermal Growth Factor; Humans; Insulin; MAP Kinase Signaling System; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Neuropeptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteins; Ras Homolog Enriched in Brain Protein; Rats; Regulatory-Associated Protein of mTOR; Serine; Structure-Activity Relationship; Tandem Mass Spectrometry; Thermodynamics; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2010 |
Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine nucleotide exchange factor, FGD1.
Topics: Biological Transport; Cell Membrane; Epidermal Growth Factor; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Isoleucine; Mutation; Proline; Protein Structure, Tertiary; Serine; Signal Transduction; Translocation, Genetic; Wound Healing | 2010 |
Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Flavonoids; Humans; Molecular Sequence Data; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Serine | 2010 |
7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoflavones; Mice; Phosphatidylinositol 3-Kinases; Retinoblastoma Protein; Serine; Skin Neoplasms | 2010 |
Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Blotting, Western; Calcium; Calcium Channels; Cell Line; Cell Proliferation; Endoplasmic Reticulum; Epidermal Growth Factor; Fluorescent Antibody Technique; HEK293 Cells; Humans; Mutation; Phosphorylation; Protein Kinase C; RNA Interference; Serine; TRPP Cation Channels | 2010 |
Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase 2; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Transfection; Versicans | 2010 |
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
Topics: Actins; Blotting, Western; Cell Line, Tumor; Cell Movement; Cortactin; Epidermal Growth Factor; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Dynamics Simulation; Neoplasms; Phosphorylation; Protein Conformation; Pseudopodia; RNA Interference; Serine; Tyrosine; Wiskott-Aldrich Syndrome Protein | 2010 |
Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Adhesion; Cell Cycle Proteins; Cell Growth Processes; Cell Transformation, Neoplastic; DNA-Activated Protein Kinase; DNA-Binding Proteins; Epidermal Growth Factor; HeLa Cells; Histones; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tumor Suppressor Proteins; Ubiquitination | 2011 |
Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription.
Topics: Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Histones; Mice; Phosphorylation; Promoter Regions, Genetic; RNA Polymerase III; RNA, Transfer, Leu; Serine; Signal Transduction; TATA-Box Binding Protein; Transcription Factor TFIIIB; Transcription, Genetic | 2011 |
Phosphorylation of histone H2B serine 32 is linked to cell transformation.
Topics: Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; Epidermis; HEK293 Cells; Histones; Humans; Mice; Mice, Knockout; Mutation, Missense; Phosphorylation; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Transcription Factor AP-1 | 2011 |
Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor.
Topics: Base Sequence; Cell Cycle; Cell Membrane; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; HT29 Cells; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Serine; Ultraviolet Rays | 2011 |
Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liver.
Topics: Adaptor Proteins, Signal Transducing; Animals; Epidermal Growth Factor; Gene Expression; Growth Hormone; Liver; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinase; Phosphoproteins; Phosphorylation; Protein Binding; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Serine; Signal Transduction; Threonine; TOR Serine-Threonine Kinases | 2012 |
Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.
Topics: Apoptosis; Carrier Proteins; Cell Adhesion; Cell Line, Tumor; Cell Survival; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Integrin beta1; Phosphorylation; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Receptors, G-Protein-Coupled; RNA, Small Interfering; Serine; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases | 2012 |
Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Checkpoint Kinase 1; Epidermal Growth Factor; Gene Expression Regulation; Humans; Mass Spectrometry; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinases; Serine; Signal Transduction; Tumor Suppressor Proteins | 2012 |
ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70.
Topics: Animals; Butadienes; Cell Line, Tumor; Cell Membrane; Epidermal Growth Factor; Exocytosis; Golgi Apparatus; HEK293 Cells; HeLa Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multiprotein Complexes; Mutation; Nitriles; Phosphorylation; Protein Binding; Rats; Recombinant Proteins; Secretory Vesicles; Serine; Signal Transduction; Vesicular Transport Proteins | 2012 |
EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung cancer cell growth.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Serine; Tandem Mass Spectrometry; Tyrosine | 2012 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glioblastoma; Glucose; Glycolysis; HEK293 Cells; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; I-kappa B Kinase; Lactic Acid; Membrane Proteins; Mice; Mice, Nude; Mutagenesis, Site-Directed; Mutation; Neoplasm Grading; Neoplasm Transplantation; NF-kappa B; Phospholipase C gamma; Phosphorylation; Polypyrimidine Tract-Binding Protein; Prognosis; Promoter Regions, Genetic; Protein Kinase C-epsilon; RNA Interference; Serine; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Transcription Factor RelA; Transfection; Ubiquitination; Up-Regulation | 2012 |
The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation.
Topics: 14-3-3 Proteins; Endopeptidases; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Mutagenesis; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Serine; src-Family Kinases; Transforming Growth Factor alpha; Tyrosine; Ubiquitin Thiolesterase | 2013 |
PTPα-mediated Src activation by EGF in human breast cancer cells.
Topics: Acetophenones; Benzopyrans; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Immunoblotting; Mutation; Phosphorylation; Protein Binding; Protein Kinase C-delta; Proto-Oncogene Proteins pp60(c-src); Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA Interference; Serine; Signal Transduction; Tyrosine | 2013 |
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Angiotensin II; Blotting, Western; Cell Line, Tumor; EGF Family of Proteins; Enzyme Activation; Epidermal Growth Factor; Flow Cytometry; Glycoproteins; HEK293 Cells; Humans; Intercellular Signaling Peptides and Proteins; Isoenzymes; Jurkat Cells; Ligands; Phosphorylation; Protein Kinase C; Proteins; Proteolysis; RNA Interference; Serine; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 2013 |
Swiprosin-1 modulates actin dynamics by regulating the F-actin accessibility to cofilin.
Topics: Actin Depolymerizing Factors; Actins; Adaptor Proteins, Signal Transducing; Animals; Calcium-Binding Proteins; Cell Membrane; Epidermal Growth Factor; Humans; Mice; Microfilament Proteins; Phosphorylation; Serine; Signal Transduction; Tumor Cells, Cultured | 2013 |
p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Line, Tumor; Chromatography, Liquid; Enzyme Inhibitors; Epidermal Growth Factor; HEK293 Cells; HeLa Cells; Humans; Imidazoles; Immunoblotting; Nanotechnology; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA Interference; Serine; Signal Transduction; Tandem Mass Spectrometry; Tumor Necrosis Factor-alpha | 2014 |
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368.
Topics: Animals; Cell Communication; Cells, Cultured; Coculture Techniques; Connexin 43; Embryonic Stem Cells; Endocytosis; Enzyme Activation; Epidermal Growth Factor; Gap Junctions; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Serine | 2014 |
Nox1 activation by βPix and the role of Ser-340 phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Amino Acid Substitution; Caco-2 Cells; Enzyme Activation; Epidermal Growth Factor; Guanosine Triphosphate; Humans; Hydrolysis; Mutagenesis, Site-Directed; NADPH Oxidase 1; NADPH Oxidases; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; rac GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; Serine; Superoxides | 2014 |
Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation.
Topics: Animals; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epoxy Compounds; Flow Cytometry; Immunoprecipitation; Mice; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Proteolysis; Proto-Oncogene Proteins c-jun; Pyrones; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry.
Topics: 14-3-3 Proteins; 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Enzyme Inhibitors; Epidermal Growth Factor; HEK293 Cells; Humans; Insulin; Mice; Phosphopeptides; Phosphoproteins; Phosphorylation; Proteomics; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Tandem Mass Spectrometry; Threonine; TOR Serine-Threonine Kinases | 2015 |
Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation.
Topics: Acetylglucosamine; Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioma; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Macrophage Migration-Inhibitory Factors; Matrix Metalloproteinase 13; Mice, Nude; Microscopy, Fluorescence; Mutation; Phosphorylation; Protein Binding; RNA Interference; Serine; Survival Analysis; Threonine; Transplantation, Heterologous | 2015 |
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
Topics: Acetylation; Animals; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Colorectal Neoplasms; Epidermal Growth Factor; Female; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Phosphorylation; Protein Binding; Protein Kinase C-epsilon; RNA Interference; Serine; Transcription Factor RelA; Transplantation, Heterologous | 2017 |
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway.
Topics: Amino Acid Sequence; Cell Line, Tumor; Disease Progression; Epidermal Growth Factor; Feedback, Physiological; Fibroblast Growth Factor 1; Humans; MAP Kinase Signaling System; Mutation; Neoplasms; Phosphorylation; Receptor, Fibroblast Growth Factor, Type 2; Serine; Signal Transduction | 2019 |
ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Glycine; Humans; Mice, Inbred BALB C; Mice, Nude; Nuclear Factor 90 Proteins; Nuclear Proteins; Prognosis; Protein Binding; Protein Stability; Repressor Proteins; RNA Stability; Serine; Substrate Specificity; Survival Analysis; Ubiquitin-Protein Ligases | 2020 |
Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation.
Topics: Animals; Antibody Specificity; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Humans; MCF-7 Cells; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Point Mutation; Protein Isoforms; raf Kinases; ras Proteins; Receptor Protein-Tyrosine Kinases; Serine; Signal Transduction; Spheroids, Cellular | 2021 |
Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF-ERK1/2 signaling pathways.
Topics: Epidermal Growth Factor; Glucose; Humans; MAP Kinase Signaling System; Multienzyme Complexes; Phosphorylation; Serine; Subcellular Fractions | 2022 |
eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer.
Topics: Colorectal Neoplasms; Epidermal Growth Factor; Humans; Serine; Signal Transduction | 2023 |