serine has been researched along with dizocilpine maleate in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.75) | 18.7374 |
| 1990's | 13 (22.81) | 18.2507 |
| 2000's | 23 (40.35) | 29.6817 |
| 2010's | 16 (28.07) | 24.3611 |
| 2020's | 4 (7.02) | 2.80 |
| Authors | Studies |
|---|---|
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Peeters, BW; Vanderheyden, PM | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Contreras, PC | 1 |
| Marvizón, JC; Skolnick, P | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Gonzalez, J; Leslie, SW; Randall, PK; Spuhler-Phillips, K | 1 |
| Baran, H; Hönack, D; Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Fedele, E; Foster, AC | 1 |
| Hirai, H; Okada, Y | 1 |
| Sharpe, LG; Steele, TD; Witkin, JM | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H | 1 |
| Carlsson, A; Carlsson, ML; Nilsson, M | 1 |
| Butelman, ER; Campbell, CM; Woods, JH | 1 |
| Hashimoto, A; Kanda, J; Oka, T | 1 |
| Bordeleau, M; Brooks, KM; Corbett, TJ; de Lannoy, I; Hendrix, JA; Kafka, S; Kamboj, RK; Kapples, KJ; Laws-Ricker, L; Lee, DK; Owolabi, J; Palermo, MG; Rizkalla, G; Shimshock, SJ; Shutske, GM; Tomer, JD; Vargas, HM | 1 |
| Berger-Sweeney, J; Bergeron, R; Caine, SB; Coyle, JT; Dunham, KS; Jiang, Z; Martina, M; Ralph-Williams, RJ; Tsai, G | 1 |
| Brenner, GJ; Ji, RR; Shaffer, S; Woolf, CJ | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Chan, HH; Chan, LN; Chang, DC; Han, Y; Lee, NT; Li, M; Li, W; Pi, R; Pu, Y; Sucher, NJ | 1 |
| Labrie, V; Lipina, T; Roder, J; Weiner, I | 1 |
| Ahn, YM; Juhnn, YS; Kim, SH; Kim, Y; Kim, YS; Seo, MS; Yoon, SC | 1 |
| Coulson, JM; Mori, N; Morii, H; Nakano, I; Yamada, T | 1 |
| Deutsch, SI; Long, KD; Mastropaolo, J; Rosse, RB | 1 |
| Deutsch, SI; Long, KD; Manaye, KF; Mastropaolo, J; Rosse, RB | 1 |
| Han, X; Hua, Y; Jiang, J; Lu, YM; Luo, CX; Zhou, QG; Zhu, DY; Zhu, XJ | 1 |
| Andoh, H; Hashimoto, A; Kawaguchi, M; Kobayashi, H; Matsumoto, H; Oka, T; Yano, H; Yoshikawa, M | 1 |
| Bennett, S; Gronier, B | 1 |
| Bai, D; Gong, XQ; Zabek, RL | 1 |
| Chaki, S; Hashimoto, K; Karasawa, J | 1 |
| Fujita, Y; Hashimoto, K; Hashimoto, T; Iyo, M; Kanahara, N; Kohno, M; Matsuzawa, D; Ohgake, S; Shimizu, E; Shirayama, Y | 1 |
| Bagetta, G; Berliocchi, L; Cavaliere, F; Corasaniti, MT; Gliozzi, M; Mazzei, C; Morrone, LA; Nucci, C; Rotiroti, D; Russo, R; Tassorelli, C | 1 |
| Chen, YS; Huang, HS; Lee, SH; Ma, MC | 1 |
| Darden, TA; Huang, Y; Li, W; Mahadevan, A; Malpica-Llanos, T; Nath, A; Reid, R; Satishchandra, P; Shankar, SK; Steiner, J | 1 |
| Brandon, NJ; Hinchliffe, RM; Huszar, SL; Hutson, PH; Jacobson, MA; Jones, B; Kandebo, M; McNaughton, CH; Mullins, CM; Pascarella, DM; Sachs, N; Smith, SM; Sparey, T; Surles, NO; Uslaner, JM; Venkatraman, S; Yao, L; Young, MB | 1 |
| Ferraris, D; Fujita, Y; Hashimoto, K; Horio, M; Iyo, M; Kunitachi, S; Tsukamoto, T | 1 |
| Booij, J; de Bruin, K; Knol, RJ; Pimlott, S; van Eck-Smit, BL; Wyper, DJ | 1 |
| Ahabrach, H; Boix, J; ElMlili, N; Errami, M; Felipo, V; Rodrigo, R | 1 |
| Huszar, SL; Hutson, PH; McNaughton, CH; Uslaner, JM; Vardigan, JD | 1 |
| Chaki, S; Kaku, A; Shimazaki, T | 1 |
| Liu, ZA; Pei, DS; Xu, J; Xu, TJ | 1 |
| Burket, JA; Cannon, WR; Deutsch, SI; Herndon, AL; Jacome, LF | 1 |
| Amaral, OB; Bado, P; de Oliveira, RV; Madeira, C; Maretti, L; Moulin, TC; Panizzutti, R; Vargas-Lopes, C; Wasilewska-Sampaio, AP | 1 |
| Ding, JH; Hu, G; Huang, X; Kong, H; Lu, M; Tang, M | 1 |
| Abazyan, B; Abazyan, S; Ma, TM; Nomura, J; Pletnikov, MV; Sawa, A; Seshadri, S; Snyder, SH; Yang, C | 1 |
| Kaster, MP; Machado, DG; Rodrigues, AL; Santos, AR | 1 |
| Camp, M; Debrouse, L; Grant, SG; Gunduz-Cinar, O; Holmes, A; Hurd, B; Kiselycznyk, C; Mishina, M; Plitt, A; Todaro, A | 1 |
| Bator, E; Dudys, D; Guzik, R; Maćkowiak, M; Wędzony, K | 1 |
| Chaki, S; Hikichi, H; Kaku, A; Kambe, D; Karasawa, J; Kawaura, K; Kinoshita, K; Koike, H | 1 |
| Huang, HS; Hung, SF; Lin, CS; Ma, MC | 1 |
| Anderson, EM; Caudle, RM; Kapernaros, K; Neubert, JK; Reeves, T | 1 |
| Liu, D; Mao, S; Peng, Y; Qin, X; Zhang, R; Zhou, X | 1 |
| Koizumi, K; Nabeta, R; Nakamura, Y; Oka, JI; Sasaki-Hamada, S | 1 |
| Fang, MS; Guo, C; Ke, D; Li, W; Li, Y; Liu, R; Liu, Y; Mahaman, YAR; Shen, H; Shu, X; Wang, JZ; Wang, X; Xia, Y; Zeng, K | 1 |
| Alatrash, N; Armstrong, DW; Berthod, A; Du, S; MacDonnell, FM; Sung, YS; Wang, Y; Wey, M | 1 |
| Balu, DT; Coyle, JT; Takagi, S | 1 |
| Asadpour, R; Hamidian, G; Mazaheri, Z; Noghani, AE; Rodriguez-Wallberg, KA; Saberivand, A | 1 |
57 other study(ies) available for serine and dizocilpine maleate
| Article | Year |
|---|---|
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Strychnine | 1992 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia.
Topics: Animals; Ataxia; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Phencyclidine; Rats; Rats, Inbred Strains; Serine; Stereotyped Behavior | 1990 |
An endogenous modulator of N-methyl-D-aspartate receptor-coupled glycine receptors.
Topics: Animals; Brain Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Stereoisomerism | 1990 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
Alteration of [3H]MK-801 binding associated with the N-methyl-D-Aspartate receptor complex by acute ethanol in rat cortex and hippocampus in vitro.
Topics: Animals; Cerebral Cortex; Culture Techniques; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Glutamic Acid; Glycine; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Serine; Synaptic Membranes; Synaptic Transmission | 1995 |
Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cycloserine; Dizocilpine Maleate; Electric Stimulation; Epilepsy, Complex Partial; Female; Glycine; Kindling, Neurologic; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine | 1994 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1993 |
Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Hypoxia; In Vitro Techniques; Kynurenic Acid; Neurons; Phosphocreatine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 1993 |
Effects of strychnine-insensitive glycine receptor ligands in rats discriminating dizocilpine or phencyclidine from saline.
Topics: Animals; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 1997 |
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine | 1997 |
Glycine and D-serine decrease MK-801-induced hyperactivity in mice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Injections, Intraventricular; Male; Mice; Motor Activity; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 1997 |
Effects of (+)-HA-966, CGS-19755, phencyclidine, and dizocilpine on repeated acquisition of response chains in pigeons: systemic manipulation of central glycine sites.
Topics: Animals; Central Nervous System; Columbidae; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Phencyclidine; Pipecolic Acids; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serial Learning; Serine | 1999 |
Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Perfusion; Rats; Rats, Wistar; Serine; Time Factors; Veratridine | 2000 |
Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.
Topics: Administration, Oral; Animals; Apomorphine; Benzyl Compounds; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Indoles; Infusions, Parenteral; Isoxazoles; Piperidines; Prazosin; Rats; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2002 |
Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.
Topics: Amino Acid Transport Systems, Neutral; Amphetamines; Animals; Behavior, Animal; Central Nervous System Stimulants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Targeting; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Patch-Clamp Techniques; Phenotype; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Serine; Sodium; Synapses | 2004 |
Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons.
Topics: Animals; Blotting, Western; Cell Count; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Heat-Shock Proteins; Hot Temperature; Immunohistochemistry; Male; Microscopy, Confocal; Molecular Chaperones; Nociceptors; Pain Measurement; Phosphopyruvate Hydratase; Phosphorylation; Physical Stimulation; Posterior Horn Cells; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord; Temperature; Time Factors | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Cell Count; Cell Survival; Cells, Cultured; Cerebellum; Chromatin; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Humans; Membrane Potentials; Microscopy, Confocal; Minocycline; N-Methylaspartate; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factors | 2004 |
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
Topics: Amino Acid Transport Systems, Neutral; Animals; Attention; Clozapine; Conditioning, Psychological; Disease Models, Animal; Dizocilpine Maleate; Glycine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2005 |
Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection.
Topics: Actins; Animals; Blotting, Western; Catenins; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Injections, Intraperitoneal; Male; Phosphorylation; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine | 2005 |
Site-specific phosphorylation of SCG10 in neuronal plasticity: role of Ser73 phosphorylation by N-methyl D-aspartic acid receptor activation in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Male; Membrane Proteins; Microtubule Proteins; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nerve Growth Factors; Neurons; Pentylenetetrazole; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Time Factors | 2006 |
Exogenously administered D-serine failed to potentiate the ability of MK-801 to antagonize electrically precipitated seizures in nonhandled control and stressed mice.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electroshock; Male; Mice; Neuroprotective Agents; Seizures; Serine | 2007 |
Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred BALB C; Receptors, N-Methyl-D-Aspartate; Sarcosine; Seizures; Serine; Stress, Physiological; Synaptic Transmission | 2006 |
Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation.
Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Dizocilpine Maleate; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type I; Phosphorylation; Serine | 2006 |
Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain.
Topics: Animals; Brain; D-Amino-Acid Oxidase; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Male; Racemases and Epimerases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine | 2007 |
Effects of antipsychotic treatments and D-serine supplementation on the electrophysiological activation of midbrain dopamine neurons induced by the noncompetitive NMDA antagonist MK 801.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Dizocilpine Maleate; Dopamine; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Haloperidol; Male; Mesencephalon; Microelectrodes; Neurons; Olanzapine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2007 |
D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons.
Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Molecular Structure; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Valine | 2007 |
D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Cognition; Cognition Disorders; Dizocilpine Maleate; Exploratory Behavior; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Nootropic Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Sarcosine; Serine; Statistics, Nonparametric | 2008 |
Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801.
Topics: Animals; Antimetabolites; Chromatography, High Pressure Liquid; Cycloserine; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Injections, Intraperitoneal; Male; Mice; Microdialysis; Quinolones; Reflex, Startle; Serine | 2008 |
Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade.
Topics: Analysis of Variance; Androstadienes; Animals; bcl-Associated Death Protein; Cell Death; Chromones; Dizocilpine Maleate; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Intraocular Pressure; Ischemia; Male; Morpholines; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retinal Diseases; Serine; Signal Transduction; Time Factors; Wortmannin | 2008 |
Mechanosensitive N-methyl-D-aspartate receptors contribute to sensory activation in the rat renal pelvis.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Kidney; Kidney Cortex; Kidney Medulla; Mechanoreceptors; Neurons, Afferent; Quinuclidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Substance P | 2008 |
NMDA receptor activation by HIV-Tat protein is clade dependent.
Topics: Amino Acid Motifs; Animals; Antibodies; Cells, Cultured; Cysteine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; Models, Molecular; Mutagenesis, Site-Directed; Neurons; Nitric Oxide Donors; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Serine; tat Gene Products, Human Immunodeficiency Virus; Transfection; Valine | 2008 |
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.
Topics: Aged; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Habituation, Psychophysiologic; Humans; Male; Models, Molecular; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Serine; Thiophenes | 2009 |
Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine.
Topics: Acoustic Stimulation; Amino Acid Oxidoreductases; Animals; Brain Chemistry; Dizocilpine Maleate; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Isoxazoles; Male; Mice; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Serine | 2009 |
In vivo [(123)I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats.
Topics: Adipose Tissue; Animals; Autoradiography; Binding Sites; Blood; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agents; Guanidines; Heart; Kidney; Lung; Male; Muscles; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Spleen; Time Factors | 2009 |
Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebellum; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperammonemia; In Vitro Techniques; Male; Microdialysis; Nitrates; Nitric Oxide Synthase Type I; Nitrites; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Statistics, Nonparametric; Subcellular Fractions; Threonine | 2010 |
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?
Topics: Allosteric Regulation; Animals; Benzamides; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Pyrazoles; Quinine; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Schizophrenia; Serine; Sucrose | 2010 |
D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Social Behavior; Time Factors | 2010 |
Calcium/calmodulin-dependent kinase II facilitated GluR6 subunit serine phosphorylation through GluR6-PSD95-CaMKII signaling module assembly in cerebral ischemia injury.
Topics: Analysis of Variance; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GluK2 Kainate Receptor; Immunoprecipitation; In Situ Nick-End Labeling; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Ischemic Attack, Transient; Male; Membrane Proteins; Nifedipine; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Serine; Signal Transduction; Sulfonamides | 2010 |
D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Male; Mice; Mice, Inbred BALB C; Motor Activity; Receptors, N-Methyl-D-Aspartate; Serine; Social Behavior | 2011 |
Effects of low-dose D-serine on recognition and working memory in mice.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred BALB C; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Serine; Time Factors | 2011 |
D-Serine regulates proliferation and neuronal differentiation of neural stem cells from postnatal mouse forebrain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bromodeoxyuridine; Calcium; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Chromatography, High Pressure Liquid; CREB-Binding Protein; Culture Media, Conditioned; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; MAP Kinase Kinase Kinases; Mice; Neural Stem Cells; Prosencephalon; Serine; Signal Transduction; Sodium Benzoate | 2012 |
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Astrocytes; Brain; Cell Line, Transformed; Cycloheximide; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Glial Fibrillary Acidic Protein; Humans; Inhibition, Psychological; Leupeptins; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Protein Binding; Racemases and Epimerases; Reflex, Startle; Schizophrenia; Serine; Transfection | 2013 |
Involvement of NMDA receptors in the antidepressant-like action of adenosine.
Topics: Adenosine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chlorides; Depression; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Imipramine; Immobilization; Ketamine; Male; Mice; N-Methylaspartate; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Serine; Swimming; Time Factors; Zinc Compounds | 2012 |
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
Topics: Alcoholic Intoxication; Animals; Ataxia; Cycloserine; Disease Models, Animal; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Drug Therapy, Combination; Glycine Plasma Membrane Transport Proteins; Guanylate Kinases; Hypothermia; Kynurenic Acid; Magnesium; Male; Membrane Proteins; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex, Righting; Sarcosine; Serine | 2013 |
MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex.
Topics: Acetylation; Animals; Antipsychotic Agents; Chromatin Assembly and Disassembly; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Histones; Lysine; Male; Phenotype; Phosphorylation; Prefrontal Cortex; Protein Processing, Post-Translational; Psychoses, Substance-Induced; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Risperidone; Serine; Time Factors | 2013 |
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Glycine; Glycine Plasma Membrane Transport Proteins; Haloperidol; Imipramine; Locomotion; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Serine; Swimming | 2015 |
Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Dizocilpine Maleate; Dogs; Endotoxemia; Excitatory Amino Acid Antagonists; Hemodynamics; Interleukin-1beta; Kidney Function Tests; Kidney Tubules, Distal; Kidney Tubules, Proximal; Lipopolysaccharides; LLC-PK1 Cells; Madin Darby Canine Kidney Cells; Male; Racemases and Epimerases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Interference; RNA, Messenger; RNA, Small Interfering; Serine; Swine; Toll-Like Receptor 4 | 2015 |
Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal.
Topics: Analgesics, Opioid; Animals; Calcineurin; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Morphine; Nucleus Accumbens; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reward; Serine; Substance Withdrawal Syndrome | 2015 |
Modulation of glycine sites enhances social memory in rats using PQQ combined with d-serine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Drug Contamination; Drug Synergism; Glycine; Haloperidol; Male; Memory; Memory Disorders; Neuroprotective Agents; PQQ Cofactor; Rats; Rats, Sprague-Dawley; Serine; Social Behavior; Time Factors | 2016 |
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like Peptide 2; Indazoles; Male; Methylene Blue; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sildenafil Citrate; Swimming | 2019 |
ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fatty Acids, Omega-3; Male; Organ Culture Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Schizophrenia; Serine; Signal Transduction | 2020 |
Roles of N-methyl-D-aspartate receptors and D-amino acids in cancer cell viability.
Topics: Alanine; Amino Acids; Asparagine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Humans; Memantine; Middle Aged; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Serine; Skin Neoplasms | 2020 |
Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.
Topics: Animals; Brain; Cocaine; Corpus Striatum; D-Amino-Acid Oxidase; Dizocilpine Maleate; Female; Gene Expression; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Quinoxalines; Racemases and Epimerases; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serine | 2021 |
Differentiation of neonate mouse spermatogonia on two-dimensional and three-dimensional culture systems supplemented with d-Serine and Dizocilpine (MK-801).
Topics: Animals; Dizocilpine Maleate; Male; Mice; Receptors, N-Methyl-D-Aspartate; Serine; Spermatogenesis; Spermatogonia; Testis | 2022 |