serine has been researched along with cyclin d1 in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.26) | 18.2507 |
| 2000's | 33 (57.89) | 29.6817 |
| 2010's | 19 (33.33) | 24.3611 |
| 2020's | 2 (3.51) | 2.80 |
| Authors | Studies |
|---|---|
| Grafstrom, R; Hoess, R; Pan, W; Sun, T | 1 |
| Drullinger, LF; Dulić, V; Soulard, A; Stein, GH | 1 |
| Grafstrom, RH; Hoess, RH; Pan, W | 1 |
| Bijur, GN; Jope, RS | 1 |
| Ajima, R; K-Tsuzuku, J; Nakamura, T; Suzuki, T; Yamamoto, T; Yoshida, Y | 1 |
| Bangash, S; Lopatka, K; Paller, AS; Sun, P; Wang, XQ | 1 |
| Gelman, IH; Husain, M; Nelson, PJ; Sunamoto, M | 1 |
| Martin, AM; Meek, DW; Perkins, ND; Rocha, S | 1 |
| Gines, S; Ivanova, E; MacDonald, ME; Saura, CA; Seong, IS | 1 |
| Lange, CA | 1 |
| Griffin, JD; Ikeda, Y; Kizaki, M; Miyakawa, Y; Sawafuji, K; Weisberg, E | 1 |
| Pestell, RG; Pradeep, A; Rana, B; Sharma, C | 1 |
| Garnovskaya, MN; Grewal, JS; Mukhin, YV; Raymond, JR; Tholanikunnel, BG; Ullian, ME; Vlasova, TM | 1 |
| Balasenthil, S; Barnes, CJ; Kumar, R; Rayala, SK | 1 |
| Bai, J; Ban, S; Kwon, YW; Nakamura, H; Tanaka, T; Ueda, S; Yodoi, J | 1 |
| Faivre, E; Lange, CA; Skildum, A | 1 |
| Ahn, YM; Juhnn, YS; Kang, UG; Kim, Y; Kim, YS; Seo, MS; Yoon, SC | 1 |
| Debidda, M; Poli, V; Wang, L; Zang, H; Zheng, Y | 1 |
| Wang, MH; Xu, XM; Zhou, YQ | 1 |
| Behring, A; Goyal, P; Pandey, D; Siess, W | 1 |
| Harada, C; Harada, T; Kase, S; Nakayama, KI; Namekata, K; Ohgami, K; Ohno, S; Shiratori, K; Suzuki, Y; Yoshida, K | 1 |
| Guo, J; Sheng, G; Warner, BW | 1 |
| Joung, YH; Kim, SY; Lee, KJ; Lee, MY; Lim, EJ; Moon, WK; Park, DK; Park, EU; Park, JH; Park, T; Yang, YM; Ye, SK; Zhang, Z | 1 |
| Misra, UK; Pizzo, SV | 1 |
| Chen, D; Drissi, H; Liu, F; O'Keefe, RJ; Shen, R; Wang, X | 1 |
| Berman, DM; Dong, Q; Gu, J; Gutkind, JS; Lin, X; Romeo, MJ; Wu, X | 1 |
| Cox, BD; Gladson, CL; Natarajan, M; Stettner, MR | 1 |
| Choi, KY; Chun, JS; Lee, MS; Oh, HJ; Park, CS; Song, WK; Yeo, MG | 1 |
| Cai, L; Lü, J; Wu, H; Zou, J | 1 |
| Baltzis, D; Gao, HQ; Koromilas, AE; Mounir, Z; Papadakis, AI; Raven, JF; Wang, S | 1 |
| Bernath, A; Gera, J; Jo, OD; Lichtenstein, A; Martin, J; Masri, J | 1 |
| Albrecht, JH; Huichalaf, C; Nguyen, H; Sakai, K; Salisbury, E; Schneider-Gold, C; Schoser, B; Timchenko, LT; Wang, GL | 1 |
| Auboeuf, D; Barbier, J; Bittencourt, D; Dutertre, M; Gratadou, L; Sanchez, G | 1 |
| Chang, TY; Chou, CY; Giri, R; Liu, HS; Su, WC; Yeh, HH | 1 |
| Chen, D; Hou, W; Jonason, JH; Shen, R; Wang, B; Wang, Q; Wang, X; Xie, R; Zhang, M; Zhu, T | 1 |
| Hammond, JD; Lu, H; Ma, JQ; Mehta, TS; Monzur, F; Nguyen, KH; Urvalek, AM; Wang, X; Zhao, J | 1 |
| Cheng, JQ; Coppola, D; Esposito, NN; Guo, JP; Koomen, JM; Shu, SK | 1 |
| Chen, H; Guo, C; Huang, L; Li, J; Mei, L; Wang, H; Zhang, X; Zheng, Y; Zhou, L; Zhu, Y | 1 |
| Barbash, O; Diehl, JA; Lee, EK | 1 |
| Duplessis, TT; Hill, SM; Rowan, BG; Williams, CC | 1 |
| Almvig, K; Christensen, MS; Jensen, TH; Mapendano, CK; Preker, P; Sandelin, A; Valen, E | 1 |
| Adachi, S; Hirose, Y; Itani, M; Kawaguchi, J; Kozawa, O; Moriwaki, H; Nakamura, M; Nakashima, M; Nishii, Y; Okano, Y; Shimizu, M; Yamauchi, T; Yasuda, I; Yoshioka, T | 1 |
| Choi, JW; Chung, JH; Jin, T; Kang, SM; Kim, SH; Kim, SY; Lee, BS; Lee, KH; Oh, J; Won, HY | 1 |
| Bakowska, JC; Das, S; Kanthasamy, A; Lee, TH; Lu, KP; Malter, JS; Mishra, R; Rana, A; Rana, B; Rangasamy, V; Sondarva, G; Tzivion, G | 1 |
| Gafken, P; Kloet, SL; Ranish, J; Wang, EH; Whiting, JL | 1 |
| Huikko, L; Luoma-Halkola, H; Marttinen, M; Mutanen, M; Päivärinta, E; Pajari, AM; Piironen, V; Storvik, M | 1 |
| Gao, J; Jiang, J; Li, X | 1 |
| Anderton, DL; Arcaro, KF; Bentley, BA; Fagan-Solis, KD; Gozgit, JM; Marconi, SM; Otis, CN; Pentecost, BT; Schneider, SS | 1 |
| Bhowmik, A; Chatterjee, A; Chatterjee, S; Chatterjee, U; Ghosh, MK; Mandal, T | 1 |
| Becker, W; Florencio Ortiz, V; Pasqualon, T; Schumacher, J; Soppa, U; Tejedor, FJ | 1 |
| Fukui, T; Kishimoto, M; Mitsuyama, T; Miyamoto, S; Nishio, A; Okazaki, K; Sakaguchi, Y; Suzuki, R; Takahashi, Y; Takeo, M; Uchida, K | 1 |
| Chowdhury, MK; Cognard, E; Montgomery, MK; Morris, MJ; Shepherd, PR; Smith, GC | 1 |
| Cai, X; Chu, Y; Fan, D; Fan, X; Horvath, T; Jiang, M; Li, X; Liang, J; Nie, Y; Qiu, Z; Wang, W; Wu, K; Xu, B; Yang, X; Zhang, S; Zhang, X; Zhou, J | 1 |
| Ganapathy, V; Osman, I; Poulose, N; Segar, L | 1 |
| Alimov, A; Englund, DA; Figueiredo, VC; McCarthy, JJ; Peterson, CA; Vechetti, IJ | 1 |
| Gao, X; Golden, JA; Lin, W; Shi, X; Tao, T; Xie, W | 1 |
| Bi, H; Fan, S; Gao, Y; Huang, M; Li, X; Liang, H; Qu, X; Tian, J; Wang, R; Yang, J; Yang, X; Zhang, S; Zhang, Y | 1 |
2 review(s) available for serine and cyclin d1
| Article | Year |
|---|---|
Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word?
Topics: Animals; CDC2-CDC28 Kinases; Cyclin D1; Cyclin-Dependent Kinase 2; GTP Phosphohydrolases; Humans; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Receptors, Progesterone; Receptors, Steroid; Serine; Signal Transduction; Transcription, Genetic | 2004 |
New concepts regarding focal adhesion kinase promotion of cell migration and proliferation.
Topics: Animals; Binding Sites; Cell Cycle; Cell Movement; Cell Proliferation; Crk-Associated Substrate Protein; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Protein Structure, Tertiary; Serine; Signal Transduction; src Homology Domains; src-Family Kinases | 2006 |
55 other study(ies) available for serine and cyclin d1
| Article | Year |
|---|---|
Defining the minimal portion of the retinoblastoma protein that serves as an efficient substrate for cdk4 kinase/cyclin D1 complex.
Topics: Animals; Cell Line; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Insecta; Kinetics; Phosphorylation; Proto-Oncogene Proteins; Recombinant Proteins; Retinoblastoma Protein; Serine; Substrate Specificity | 1998 |
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.
Topics: CDC2-CDC28 Kinases; Cell Differentiation; Cell Line; Cellular Senescence; Cyclin A; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Fibroblasts; Humans; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Retinoblastoma Protein; Serine | 1999 |
Defining the substrate specificity of cdk4 kinase-cyclin D1 complex.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Binding Sites; Conserved Sequence; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; HeLa Cells; Humans; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Serine; Substrate Specificity; Threonine | 1999 |
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta.
Topics: Apoptosis Inducing Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cyclin D1; Enzyme Inhibitors; Flavoproteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hot Temperature; Humans; Lithium; Membrane Proteins; Phosphorylation; Serine; Staurosporine; Tumor Cells, Cultured; Tyrosine | 2001 |
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
Topics: 3T3 Cells; Alanine; Animals; Carrier Proteins; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Enzyme Inhibitors; Flavonoids; G1 Phase; Glutamic Acid; Glutamine; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Mapping; Phosphorylation; Phosphoserine; Plasmids; Protein Structure, Tertiary; ras Proteins; Resting Phase, Cell Cycle; S Phase; Serine; Time Factors; Transfection | 2002 |
Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling.
Topics: Apoptosis; bcl-Associated Death Protein; Carcinoma, Squamous Cell; Carrier Proteins; Caspase 9; Caspases; Cell Survival; Cyclin D1; Cyclin E; DNA, Complementary; Fibronectins; G1 Phase; Gangliosides; Humans; Integrin beta1; Keratinocytes; Neuraminidase; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; S Phase; Serine; Signal Transduction; Skin Neoplasms; Threonine; Transfection; Tumor Cells, Cultured | 2002 |
HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy.
Topics: AIDS-Associated Nephropathy; Animals; Cell Cycle; Cells, Cultured; Cyclin D1; G1 Phase; HIV-1; Mice; Phenotype; Phosphorylation; Retinoblastoma Protein; S Phase; Serine | 2002 |
p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.
Topics: B-Cell Lymphoma 3 Protein; Cell Cycle; Cell Line; Cyclin D1; Down-Regulation; Flow Cytometry; Genes, Reporter; Histone Deacetylase 1; Histone Deacetylases; Humans; Immunoblotting; Models, Biological; Models, Genetic; NF-kappa B; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Serine; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 2003 |
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.
Topics: Alleles; Animals; beta Catenin; Cell Membrane; Cells, Cultured; Chromones; Corpus Striatum; Cyclin D1; Cytoskeletal Proteins; Cytosol; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Huntington Disease; Immunoblotting; Mice; Mice, Transgenic; Models, Biological; Morpholines; Mutation; Neurons; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Trans-Activators; Transcription, Genetic | 2003 |
Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.
Topics: Aminopeptidases; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Caspases; Cell Division; Cyclin D1; Drug Resistance, Neoplasm; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hydroxamic Acids; Imatinib Mesylate; K562 Cells; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitogen-Activated Protein Kinases; Phosphorylation; Piperazines; Protease Inhibitors; Pyrimidines; Serine; Signal Transduction | 2003 |
Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes.
Topics: Animals; beta Catenin; Blotting, Western; Cell Division; Cell Line; Chromans; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclin D1; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Genes, Reporter; Hepatocytes; Humans; Hypoglycemic Agents; Ligands; Liver; Luciferases; Mice; Mutation; Okadaic Acid; Plasmids; Receptors, Cytoplasmic and Nuclear; Serine; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone | 2004 |
Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.
Topics: Androstadienes; Angiotensin II; Animals; Aorta; Blotting, Western; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Mitogen-Activated Protein Kinases; Mitogens; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Rats; Retinoblastoma Protein; Serine; Serotonin; Time Factors; Wortmannin | 2004 |
Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells.
Topics: Amino Acid Substitution; Breast Neoplasms; Cell Line, Tumor; Cyclin D1; Estrogen Receptor alpha; Estrogens; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Confocal; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Receptors, Estrogen; Recombinant Proteins; RNA; Serine; Signal Transduction; Transfection; Up-Regulation | 2004 |
Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Blotting, Northern; Blotting, Western; Cell Cycle; Cell Division; Cell Line; Cell Line, Tumor; Cyclin D1; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Mitochondrial; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; G1 Phase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HeLa Cells; Herbicides; Humans; Ions; Leupeptins; Mitochondria; Multienzyme Complexes; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Retinoblastoma Protein; RNA Processing, Post-Transcriptional; Serine; Time Factors; Tumor Suppressor Protein p53 | 2004 |
Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases.
Topics: Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Culture Media, Serum-Free; Cyclin D1; Disease Progression; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Luciferases; MAP Kinase Signaling System; Mifepristone; Phosphorylation; Point Mutation; Progestins; Receptors, Progesterone; S Phase; Serine; Time Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2005 |
Activation of Cdk2-pRB-E2F1 cell cycle pathway by repeated electroconvulsive shock in the rat frontal cortex.
Topics: Animals; Blotting, Western; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Electroshock; Enzyme Activation; Frontal Lobe; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Retinoblastoma Protein; Serine; Time Factors; Transcription Factors | 2005 |
A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.
Topics: Actins; Active Transport, Cell Nucleus; Animals; cdc42 GTP-Binding Protein; Cell Movement; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclin D1; Cytoskeleton; DNA-Binding Proteins; DNA, Complementary; Fibroblasts; Gene Deletion; Genes, Reporter; Immunoblotting; Inflammation; Interleukin-6; Luciferases; Mice; Mice, Knockout; Microscopy, Fluorescence; Models, Biological; Mutation; Myosin Light Chains; NF-kappa B; Phosphorylation; Promoter Regions, Genetic; Protein Structure, Tertiary; rac1 GTP-Binding Protein; Retroviridae; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine; Wound Healing | 2005 |
Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase.
Topics: Active Transport, Cell Nucleus; Alternative Splicing; Androstadienes; Animals; beta Catenin; Blotting, Western; Cell Nucleus; Cyclin D1; Cytoplasm; Cytoskeletal Proteins; Enzyme Inhibitors; Gene Silencing; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Models, Biological; Neoplasms; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Receptor Protein-Tyrosine Kinases; RNA, Messenger; RNA, Small Interfering; Serine; Trans-Activators; Tyrosine; Wortmannin | 2005 |
Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.
Topics: Active Transport, Cell Nucleus; Binding Sites; Cell Nucleus; Cells, Cultured; Cyclin D1; Cytoplasm; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Activation; Fatty Acids, Unsaturated; Fluorescence Recovery After Photobleaching; G1 Phase; Humans; Immunoprecipitation; Lim Kinases; Microscopy, Fluorescence; Mutation; Phosphorylation; Pichia; Plasmids; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Proteins; Resting Phase, Cell Cycle; S Phase; Serine; Threonine; Time Factors; Transfection; Umbilical Veins | 2005 |
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Flavonoids; Fluorescent Antibody Technique, Indirect; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroglia; Phosphorylation; Proliferating Cell Nuclear Antigen; Retinal Detachment; Serine | 2006 |
Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase 4; Detergents; Epidermal Growth Factor; Epithelial Cells; Flow Cytometry; G1 Phase; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Immunoprecipitation; Intestine, Small; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Rats; Retinoblastoma Protein; S Phase; Serine; Stem Cells | 2005 |
Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
Topics: Anaerobiosis; Animals; Breast Neoplasms; Cell Hypoxia; Chlorocebus aethiops; COS Cells; Cyclin D1; Deferoxamine; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 2; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Serine; Tumor Cells, Cultured; Tyrosine | 2005 |
Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
Topics: Androstadienes; Animals; bcl-Associated Death Protein; Blotting, Western; Cell Count; Cell Proliferation; Chromones; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Gene Silencing; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Immunoprecipitation; Isoquinolines; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; rap1 GTP-Binding Proteins; RNA Interference; RNA, Double-Stranded; Serine; Signal Transduction; Sulfonamides; Threonine; Thymidine; Time Factors; Up-Regulation; Wortmannin; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Cyclin D1-cdk4 induce runx2 ubiquitination and degradation.
Topics: Animals; Cell Cycle; Chlorocebus aethiops; Core Binding Factor Alpha 1 Subunit; COS Cells; Cyclin D1; Cyclin-Dependent Kinase 4; Mice; Mice, Inbred C3H; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Binding; Serine; Ubiquitin | 2006 |
A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Topics: Aged; Alleles; Case-Control Studies; Cell Transformation, Neoplastic; Cyclin D1; DNA, Neoplasm; Female; Genotype; Glycine; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; Lung Neoplasms; Male; Mexican Americans; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Rho Guanine Nucleotide Exchange Factors; Risk Factors; Serine; Signal Transduction; Tumor Suppressor Protein p53 | 2006 |
Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells.
Topics: Animals; beta Catenin; Cattle; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase 6; Fibroblasts; Humans; Mice; Mice, Knockout; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Serine; TCF Transcription Factors; Trans-Activators; Transcription, Genetic; Wnt Proteins | 2007 |
Compensative shuttling of merlin to phosphorylation on serine 518 in vestibular schwannoma.
Topics: Active Transport, Cell Nucleus; Biological Transport, Active; Cell Cycle; Cell Nucleus; Cyclin D1; Cytoplasm; Fluorescent Antibody Technique; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Confocal; Neurofibromin 2; Neuroma, Acoustic; Phosphorylation; Resting Phase, Cell Cycle; S Phase; Serine | 2008 |
PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation.
Topics: Cell Line, Tumor; Cyclin D1; Down-Regulation; eIF-2 Kinase; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Phosphorylation; Proteasome Endopeptidase Complex; Serine; Ubiquitin | 2008 |
Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling.
Topics: Animals; Antibiotics, Antineoplastic; Binding Sites; Cell Line; Cell Line, Tumor; Cyclin D1; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Ribosomes; Serine; Sirolimus | 2008 |
Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; CELF1 Protein; Cell Differentiation; Cell Fusion; Cell Line; Cyclin D1; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Humans; Mice; Muscle Development; Muscle, Skeletal; Myoblasts; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA-Binding Proteins; RNA, Messenger; Serine; Signal Transduction | 2008 |
Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes.
Topics: Animals; Cell Line; Cyclin D1; Estradiol; Gene Expression Regulation; Humans; Introns; Proto-Oncogene Proteins c-fos; RNA Polymerase II; RNA Splicing; RNA, Messenger; Serine; Transcription, Genetic; Trefoil Factor-1; Tumor Suppressor Proteins | 2008 |
Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D1; Genes, ras; Humans; Interleukin-6; Lung Neoplasms; Mice; Neoplasm Transplantation; Phosphorylation; Serine; STAT3 Transcription Factor; Transcriptional Activation; Up-Regulation; Urinary Bladder Neoplasms | 2009 |
PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.
Topics: Animals; Chlorocebus aethiops; Chondrocytes; Core Binding Factor Alpha 1 Subunit; Core Binding Factor Alpha 3 Subunit; COS Cells; Cyclin D1; Down-Regulation; Humans; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Parathyroid Hormone-Related Protein; Phosphorylation; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Serine; Ubiquitination | 2009 |
A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers.
Topics: Animals; beta Karyopherins; Cell Nucleus; Cyclin D1; Cytoplasm; Kidney; Kruppel-Like Transcription Factors; Luciferases; Lysine; Mice; NIH 3T3 Cells; Nuclear Localization Signals; Point Mutation; Promoter Regions, Genetic; Protein Structure, Tertiary; Serine; Transcription Factors; Transcription, Genetic; Zinc Fingers | 2009 |
IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer.
Topics: Amino Acid Substitution; Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; Cyclin D1; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Humans; I-kappa B Kinase; Immunoblotting; Phosphorylation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; Tamoxifen; Transcriptional Activation; Transfection | 2010 |
Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Cell Line; Cell Nucleus; Cell Proliferation; Cyclin D1; G1 Phase; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Mice; Neurofibromin 2; Phosphorylation; Protein Binding; Resting Phase, Cell Cycle; Serine; Tumor Suppressor Proteins | 2011 |
Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ.
Topics: 14-3-3 Proteins; Animals; Cell Line; Cyclin D1; Cytoplasm; Enzyme Activation; F-Box Proteins; G1 Phase; Gene Expression Regulation; Humans; Mice; Mutation; Phosphorylation; Protein Multimerization; Protein Structure, Quaternary; Protein Transport; Rats; S Phase; Serine; SKP Cullin F-Box Protein Ligases; Ubiquitination | 2011 |
Phosphorylation of Estrogen Receptor α at serine 118 directs recruitment of promoter complexes and gene-specific transcription.
Topics: Amino Acid Motifs; Cell Line; Cyclin D1; Estradiol; Estrogen Receptor alpha; Estrogens; Humans; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-myb; Serine; Species Specificity; Transcription, Genetic; Transcriptional Activation | 2011 |
PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters.
Topics: Cyclin D1; Genes, myc; HEK293 Cells; HeLa Cells; Humans; Polyadenylation; Promoter Regions, Genetic; RNA Nucleotidyltransferases; RNA Polymerase I; RNA Polymerase II; RNA Polymerase III; RNA, Messenger; RNA, Nuclear; Serine | 2011 |
Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor.
Topics: Base Sequence; Cell Cycle; Cell Membrane; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; HT29 Cells; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Serine; Ultraviolet Rays | 2011 |
C-reactive protein induces p53-mediated cell cycle arrest in H9c2 cardiac myocytes.
Topics: C-Reactive Protein; Cell Cycle; Cell Line; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phosphorylation; Receptors, IgG; RNA, Small Interfering; Serine; Tumor Suppressor Protein p53 | 2011 |
Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Catalysis; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Centrosome; Cyclin D1; Female; Green Fluorescent Proteins; HEK293 Cells; HeLa Cells; Humans; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Serine; Signal Transduction | 2012 |
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
Topics: Animals; Cell Cycle; Cell Nucleus; Cyclin A; Cyclin D1; HeLa Cells; Histone Acetyltransferases; Histones; Humans; Insecta; Phosphorylation; Protein Interaction Mapping; Serine; TATA-Binding Protein Associated Factors; Transcription Factor TFIID; Transfection | 2012 |
Plant stanols induce intestinal tumor formation by up-regulating Wnt and EGFR signaling in Apc Min mice.
Topics: Adenoma; Animals; beta Catenin; Cecum; Cholesterol; Cyclin D1; ErbB Receptors; Female; Gene Expression Regulation; Genes, APC; Intestinal Mucosa; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 3; Phytosterols; Proto-Oncogene Proteins c-akt; Serine; Sitosterols; Sterol Regulatory Element Binding Protein 2; Up-Regulation; Wnt Signaling Pathway | 2013 |
[The study of serine/threonine kinase signaling pathway-mediated inhibition of proliferation and invasion of oral squamous cell carcinoma transfected with p53 gene].
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Proliferation; Cyclin D1; Genes, p53; Humans; Mitogen-Activated Protein Kinases; Mouth Neoplasms; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Transfection | 2013 |
SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Phosphorylation; RNA Interference; S-Phase Kinase-Associated Proteins; Serine; Signal Transduction; Transfection; Triple Negative Breast Neoplasms; Up-Regulation | 2014 |
Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Topics: Animals; bcl-X Protein; Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Cyclin D1; Glioma; HEK293 Cells; Humans; Okadaic Acid; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Serine; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transplantation, Heterologous | 2014 |
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation.
Topics: Animals; Brain; Cell Cycle; Cell Differentiation; Cell Line; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Down Syndrome; Dyrk Kinases; Humans; Mice, Inbred ICR; Neurogenesis; Neurons; Phosphorylation; Primary Cell Culture; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Threonine | 2014 |
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Carcinogenesis; Colitis; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Ki-67 Antigen; Male; Mice; Neoplastic Stem Cells; Phosphorylation; Proto-Oncogene Proteins c-myc; Serine; Signal Transduction; Smad2 Protein; Smad3 Protein; SOX9 Transcription Factor | 2015 |
Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.
Topics: Animals; beta Catenin; Cyclin D1; Gene Expression Regulation; Glucagon; Infusion Pumps; Liver; Male; Organ Culture Techniques; Phosphorylation; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Serine; Wnt Signaling Pathway | 2015 |
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling.
Topics: Acetylglucosamine; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 2; Down-Regulation; Female; Gene Knockdown Techniques; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Acetylglucosaminyltransferases; Phosphorylation; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Serine; Stomach Neoplasms; Threonine; Up-Regulation; Xenograft Model Antitumor Assays | 2016 |
High fructose-mediated attenuation of insulin receptor signaling does not affect PDGF-induced proliferative signaling in vascular smooth muscle cells.
Topics: Aorta; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Fructose; Gene Expression Regulation; Humans; Insulin Receptor Substrate Proteins; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Ribosomal Protein S6; Serine; Signal Transduction | 2016 |
Phosphorylation of eukaryotic initiation factor 4E is dispensable for skeletal muscle hypertrophy.
Topics: Animals; Biomechanical Phenomena; Cyclin D1; Eukaryotic Initiation Factor-4E; Female; Gene Expression Regulation; Gene Knock-In Techniques; Hypertrophy; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nuclear Proteins; Organelle Biogenesis; Phosphorylation; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; Ribosomes; RNA, Ribosomal; Serine; Signal Transduction | 2019 |
Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein.
Topics: Animals; Casein Kinase II; Cell Nucleus; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Cyclin-Dependent Kinase 4; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; HEK293 Cells; HeLa Cells; Homeodomain Proteins; Humans; Mice; Mice, Transgenic; Phosphorylation; Recombinant Proteins; Serine; Sf9 Cells; Spodoptera; Transcription Factors | 2020 |
Pregnane X receptor promotes liver enlargement in mice through the spatial induction of hepatocyte hypertrophy and proliferation.
Topics: Animals; Anions; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digitonin; Hepatocytes; Hepatomegaly; Hypertrophy; Liver; Mice; Mice, Inbred C57BL; NIMA-Related Kinases; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Retinoblastoma-Like Protein p130; Serine; Threonine; Triglycerides | 2022 |