serine has been researched along with cyclic gmp in 91 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 10 (10.99) | 18.7374 |
1990's | 15 (16.48) | 18.2507 |
2000's | 43 (47.25) | 29.6817 |
2010's | 22 (24.18) | 24.3611 |
2020's | 1 (1.10) | 2.80 |
Authors | Studies |
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Kuo, JF | 1 |
Li, M; Ryan, R; Wood, PL | 1 |
Cler, JA; Contreras, PC; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
Cler, JA; Contreras, PC; Dilworth, VM; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
Altenhofen, W; Bönigk, W; Eismann, E; Kaupp, UB; Kraus, W; Ludwig, J | 1 |
Cler, JA; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
Cler, JA; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
Cler, J; Contreras, PC; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
Austen, KF | 1 |
Majumder, GC; Turkington, RW | 1 |
Bron, T; Rous, S | 1 |
Huttunen, JK; Steinberg, D | 1 |
Almon, RR; Andrew, CG; Appel, SH; Roses, AD | 1 |
Keates, RA | 1 |
Carstens, ME; Neethling, AC; Taljaard, JJ; Weller, M | 1 |
Raiteri, M; Vallebuona, F | 1 |
Cheng, X; Kovac, L; Lee, JC | 1 |
Bertel, O; Hellmann, G; Hohenegger, M; Maurer-Fogy, I; Plank, B; Suko, J; Wyskovsky, W | 1 |
Bisaglia, M; Fedele, E; Raiteri, M | 1 |
Artemyev, NO; Granovsky, AE; Natochin, M | 1 |
Bönigk, W; Frings, S; Müller, F; Sesti, F | 1 |
Halldórsson, H; Jónsson, O; Kjeld, M; Thorgeirsson, G | 1 |
Adermann, K; Austermann, S; Forssmann, WG; Meyer, M; Mostafavi, H; Raida, M | 1 |
Bachmann, C; Hönig-Liedl, P; Hoschuetzky, H; Jarchau, T; Reinhard, K; Smolenski, A; Walter, U | 1 |
Busse, R; Dimmeler, S; Fisslthaler, B; Fleming, I; Hermann, C | 1 |
Taylor, MK; Uhler, MD | 1 |
Hunter, T; Potter, LR | 1 |
Bodenschatz, M; Hoffmann, N; Meinertz, T; Mollnau, H; Münzel, T; Oelze, M; Skatchkov, M; Smolenski, A; Walter, U; Warnholtz, A | 1 |
Bhattacharya, SS; Deery, EC; Hunt, DM; Newbold, RJ; Srinivasan, N; Walker, CE; Warren, MJ; Wilkie, SE | 1 |
Carrithers, SL; Carvalho, AF; Coelho, GR; Fonteles, MC; Forte, LR; Greenberg, RN; Monteiro, HS | 1 |
Haystead, TA; Liu, X; MacDonald, JA; Nakamoto, RK; Somlyo, AP; Somlyo, AV; Walker, LA | 1 |
Butt, E; Gaestel, M; Immler , D; Kotlyarov, A; Laass, K; Meyer, HE | 1 |
Gao, M; Maack, T; Nikonova, LN; Vieira, MA | 1 |
Arntz, C; Kamm, S; Korth, M; Motejlek, K; Ruth, P; Sausbier, U; Wang, GX; Zhou, XB | 1 |
Tai, HH; Yamamoto, S; Yan, F; Zhou, H | 1 |
Galle, J; Ibarra-Alvarado, C; Mameghani, A; Melichar, VO; Schmidt, HH | 1 |
Bessay, EP; Busch, JL; Corbin, JD; Francis, SH | 1 |
Cohen, RA; Hou, XY; Nagata, D; Shi, CM; Walsh, K; Zou, MH | 1 |
Hori, M; Karaki, H; Murata, T; Ozaki, H; Sato, K | 1 |
Bazan, NG; Bernatchez, PN; Gélinas, DS; Rollin, S; Sirois, MG | 1 |
Kaufman, E; Rembold, CM | 1 |
Baker, DA; Deng, W; Meyer, DJ; Parbhu-Patel, A | 1 |
Andric, SA; Kostic, TS; Stojilkovic, SS | 1 |
Alzayady, K; Soulsby, MD; Wojcikiewicz, RJ; Xu, Q | 1 |
El-Zaru, MR; Mendelsohn, ME; Surks, HK; Wang, Y | 1 |
Espey, MG; Harris, CC; Hofseth, LJ; Mancardi, D; Ridnour, LA; Thomas, DD; Wink, DA | 1 |
Bahr, I; Dernedde, J; Kilian, K; Mueller, EC; Tauber, R | 1 |
Borman, MA; Erdodi, F; Hartshorne, DJ; Haystead, TA; Ma, C; MacDonald, JA; Wooldridge, AA | 1 |
Akiyama, M; Katusic, ZS; Santhanam, AV; Sessa, WC; Smith, LA; Sorenson, J | 1 |
Heller, R; Werner, ER; Werner-Felmayer, G | 1 |
Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F | 1 |
Boss, GR; Chen, Y; Pilz, RB; Zhao, X; Zhuang, S | 1 |
Liu, Y; Miltyk, W; Phang, JM; Surazynski, A | 1 |
Grenegård, M; Gunnarsson, P; Lindström, E; Persson, AA | 1 |
Chan, SL; Chan, SS; Fiscus, RR; Fraser, M; Tsang, BK | 1 |
Huang, Y; Kwan, HY; Yao, X | 1 |
Guo, D; Huang, XY; Maack, T; Madhusoodanan, KS; McGarrigle, DK | 1 |
Hai, S; Minamiyama, Y; Okada, S; Suehiro, S; Takemura, S | 1 |
Horrigan, DM; Kim, JA; Tetreault, ML; Zimmerman, AL | 1 |
Eckert, RE; Jones, SL | 1 |
Ibe, BO; John, TA; Raj, JU | 1 |
Acierno, R; Amelio, D; Gattuso, A; Guerrieri, A; Mannarino, C; Tota, B | 1 |
Beuve, A; Fulton, D; Papapetropoulos, A; Pyriochou, A; Roussos, C; Sayed, N; Zhou, Z | 1 |
Ferro, A; Jackson, G; Ji, Y; Liu, Z; O'Kane, P; Queen, L; Xie, L | 1 |
Ishihama, Y; Ravichandran, A; Sugiyama, N; Swarup, S; Tomita, M | 1 |
Chalimoniuk, M; Langfort, J; Stepień, A; Stolecka, A; Strosznajder, JB; Ziemińska, E | 1 |
Bauer, M; Gertler, FB; Jin, BY; Liao, R; Michel, T; Sartoretto, JL | 1 |
Baehr, W; Bereta, G; Jang, GF; Kiser, PD; Palczewski, K; Wang, B | 1 |
Ahabrach, H; Boix, J; ElMlili, N; Errami, M; Felipo, V; Rodrigo, R | 1 |
Fiscus, RR; Johlfs, MG | 1 |
Abbot, B; Attarzadeh, DO; Attwater, S; Berkowitz, DE; Bugaj, L; Champion, HC; Chen, K; Hare, JM; Li, D; Nyhan, D; Ryoo, S; Shoukas, AA; Thiyagarajan, S; Tuday, EC; White, AR | 1 |
Chen, ZW; Fan, L; Furnary, A; Grove, KL; He, GW; Huang, Y; Xiao, XQ; Yang, Q | 1 |
Lawrence, DS; Priestman, MA; Sun, L | 1 |
Burnett, AL; Ferreira, JM; Rameau, GA | 1 |
d'Uscio, LV; Katusic, ZS; Smith, LA | 1 |
Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL | 1 |
Burns, ME; Gross, OP; Pugh, EN | 1 |
Braun, AP; Hurst, S; Kyle, BD; Sheng, J; Swayze, RD | 1 |
Annich, GM; Bartlett, RH; Brisbois, EJ; Handa, H; Major, TC; Meyerhoff, ME; Reynolds, MM | 1 |
Anfossi, G; Barale, C; Doronzo, G; Mattiello, L; Russo, I; Trovati, M; Viretto, M | 1 |
Bendhack, LM; Grando, MD; Pernomian, L; Silva, BR | 1 |
Blatter, LA; Edwards, JN; Groschner, K; Kockskämper, J; Maier, LS; Maxwell, JT; Nikonova, Y; Pieske, B; Pluteanu, F; Renz, S; Schmidt, K; Spiess, J; Wakula, P; Walther, S; Yang, LZ | 1 |
Chen, N; Ferro, A; Hu, Y; Passacquale, G; Shaifta, Y; Vanderslott, G; Warboys, CM; Ward, JP; Xu, Q; Zhang, Q | 1 |
Carøe Nordgaard, J; Gammeltoft, S; Kruse, LS; Kruuse, CR | 1 |
Dickey, DM; Edmund, AB; Egbert, JR; Jaffe, LA; Potter, LR; Shuhaibar, LC; Uliasz, TF; Yee, SP | 1 |
Cong, XL; Geng, XY; Li, J | 1 |
Cirino, G; d'Emmanuele di Villa Bianca, R; Donnarumma, E; Fusco, F; Mirone, V; Mitidieri, E; Pagliara, V; Russo, A; Russo, G; Sorrentino, R; Tramontano, T | 1 |
Ishidoh, K; Kamemura, N; Kishimoto, K; Komatsu, H; Miyamoto, K; Murakami, S; Sawanoi, M; Tsuji, A; Yuasa, K | 1 |
Koizumi, K; Nabeta, R; Nakamura, Y; Oka, JI; Sasaki-Hamada, S | 1 |
Bruzzone, S; Caudano, F; Damonte, G; Fedele, E; Montalto, G; Prickaerts, J; Ricciarelli, R; Salis, A; Sturla, L | 1 |
1 review(s) available for serine and cyclic gmp
Article | Year |
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Reaction mechanisms in the release of mediators of immediate hypersensitivity from human lung tissue.
Topics: Anaphylaxis; Animals; Calcium; Chemotaxis; Chromatography, Gel; Chromatography, Paper; Complement System Proteins; Cyclic AMP; Cyclic GMP; Eosinophils; Esterases; Guinea Pigs; Histamine; Histamine Release; Humans; Hypersensitivity, Immediate; Immunization; Immunoglobulin E; Isoflurophate; Leukocytes; Lung; Lung Compliance; Mast Cells; Peptides; Rats; Serine; Skin; SRS-A | 1974 |
90 other study(ies) available for serine and cyclic gmp
Article | Year |
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Changes in activities of modulatiors of cyclic AMP-dependent and cyclic GMP-dependent protein kinases in pancreas and adipose tissue from alloxan-induced diabetic rats.
Topics: Adipose Tissue; Animals; Carrier Proteins; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; Epididymis; Guinea Pigs; Lung; Male; Pancreas; Protamine Kinase; Protein Kinases; Rats; Serine | 1975 |
NMDA-, but not kainate- or quisqualate-dependent increases in cerebellar cGMP are dependent upon monoaminergic innervation.
Topics: Animals; Cerebellum; Cyclic GMP; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Clozapine attenuates N-methyl-D-aspartate receptor complex-mediated responses in vivo: tentative evidence for a functional modulation by a noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Clozapine; Cyclic GMP; Dioxanes; Haloperidol; Harmaline; Histamine H2 Antagonists; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Methamphetamine; Mice; Norepinephrine; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Ritanserin; Serine; Tropisetron | 1991 |
Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation of N-methyl-D-aspartate (NMDA) receptor complex-mediated events by sigma ligands.
Topics: Animals; Cerebellum; Cyclic GMP; Dopamine Agents; Harmaline; Ligands; Male; Methamphetamine; Mice; Pentylenetetrazole; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Serine | 1991 |
Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Cattle; Cyclic AMP; Cyclic GMP; DNA Mutational Analysis; Electric Conductivity; Ion Channel Gating; Ion Channels; Ligands; Molecular Sequence Data; Photoreceptor Cells; Protein Kinases; Sequence Alignment; Serine; Smell; Threonine; Xenopus laevis | 1991 |
Glycine, glycinamide and D-serine act as positive modulators of signal transduction at the N-methyl-D-aspartate (NMDA) receptor in vivo: differential effects on mouse cerebellar cyclic guanosine monophosphate levels.
Topics: Animals; Cerebellum; Cerebral Ventricles; Cyclic GMP; Dose-Response Relationship, Drug; Glycine; Injections, Intraventricular; Isomerism; Male; Mice; Phencyclidine; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction | 1990 |
BMY-14802 antagonizes harmaline- and D-serine-induced increases in mouse cerebellar cyclic GMP: neurochemical evidence for a sigma receptor-mediated functional modulation of responses mediated by the N-methyl-D-aspartate receptor complex in vivo.
Topics: Alkaloids; Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Harmaline; Male; Mice; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
Ifenprodil and SL 82.0715 antagonize N-methyl-D-aspartate (NMDA)-coupled glycine receptor responses in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Cyclic GMP; Glycine; Injections; Male; Mice; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Time Factors | 1989 |
Adenosine 3',5'-monophosphate-dependent and -independent protein phosphokinase isoenzymes from mammary gland.
Topics: Adenine Nucleotides; Amino Acids; Animals; Binding Sites; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Cobalt; Cyclic AMP; Cyclic GMP; Cytoplasm; Cytosine Nucleotides; Drug Stability; Electrophoresis; Enzyme Activation; Female; Histones; Hot Temperature; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lactation; Magnesium; Mammary Glands, Animal; Peptides; Phosphopeptides; Phosphorus Isotopes; Phosphotransferases; Pregnancy; Proteins; Rats; Serine; Threonine; Trypsin; Uracil Nucleotides | 1971 |
[Comparison of some in vivo effects of cyclic 3',5'-GMP and cyclic 3',5'-AMP on glucolipid metabolism in the mouse].
Topics: Acetates; Adenine Nucleotides; Adipose Tissue; Alanine; Animals; Blood Glucose; Bone and Bones; Carbon Isotopes; Cyclic AMP; Cyclic GMP; Fatty Acids; Gluconeogenesis; Glycolipids; Guanine Nucleotides; Liver; Liver Glycogen; Male; Mice; Pyruvates; Serine; Stimulation, Chemical; Time Factors; Tritium | 1971 |
Activation and phosphorylation of purified adipose tissue hormone-sensitive lipase by cyclic AMP-dependent protein kinase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adipose Tissue; Animals; Cyclic AMP; Cyclic GMP; Cytosine Nucleotides; Enzyme Activation; Epididymis; Epinephrine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Inosine Nucleotides; Kinetics; Lipase; Lumbosacral Region; Magnesium; Male; Muscles; Phosphoric Acids; Phosphorus Isotopes; Phosphotransferases; Protein Binding; Proteins; Rabbits; Rats; Rats, Inbred Strains; Serine; Time Factors; Uracil Nucleotides | 1971 |
Phosphorylation of muscle membranes: identification of a membrane-bound protein kinase.
Topics: Adenosine Triphosphate; Animals; Cell Fractionation; Cell Membrane; Cyclic AMP; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Magnesium; Molecular Weight; Muscles; Oxidative Phosphorylation; Peptides; Phosphorus Radioisotopes; Protein Kinases; Rats; Serine; Threonine | 1973 |
Cyclic nucleotide-independent protein kinase from pea shoots.
Topics: Animals; Caseins; Cattle; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic GMP; Cytosol; Electrophoresis, Paper; Histones; Hydrogen-Ion Concentration; Inosine Nucleotides; Kinetics; Nucleotides, Cyclic; Organophosphorus Compounds; Phosphoproteins; Phosphorus Radioisotopes; Plant Cells; Plants; Protein Kinases; Serine; Serum Albumin, Bovine; Subcellular Fractions; Thymus Gland | 1973 |
Characterization of protein phosphorylation in acetylcholine receptor-enriched membrane preparations from Torpedo fuscomaculata.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cyclic AMP; Cyclic GMP; Electric Organ; Kinetics; Manganese; Membranes; Phosphorylation; Phosphotransferases; Receptors, Cholinergic; Serine; Torpedo | 1982 |
Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Extracellular Space; Guanylate Cyclase; Hippocampus; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Serine; Vasodilator Agents | 1995 |
Probing the mechanism of CRP activation by site-directed mutagenesis: the role of serine 128 in the allosteric pathway of cAMP receptor protein activation.
Topics: Allosteric Regulation; Base Sequence; Chymotrypsin; Circular Dichroism; Cyclic AMP; Cyclic AMP Receptor Protein; Cyclic GMP; DNA; DNA-Binding Proteins; Fluorescence Polarization; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Serine | 1995 |
Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic GMP; Molecular Sequence Data; Muscles; Peptide Mapping; Phosphorylation; Protein Kinases; Rabbits; Receptors, Cholinergic; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Serine | 1993 |
D-serine modulates the NMDA receptor/nitric oxide/cGMP pathway in the rat cerebellum during in vivo microdialysis.
Topics: Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1997 |
The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Binding Sites; Cattle; Cell Membrane; Coumarins; Cyclic GMP; Cysteine; Fluorescent Dyes; Kinetics; Macromolecular Substances; Phosphodiesterase Inhibitors; Point Mutation; Purinones; Rod Cell Outer Segment; Serine; Vertebrates | 1997 |
Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Animals; Binding Sites; Calmodulin; Carcinogens; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Electrophysiology; Humans; Ion Channel Gating; Ion Channels; Isoenzymes; Kidney; Ligands; Molecular Sequence Data; Mutagenesis; Olfactory Receptor Neurons; Phorbol Esters; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Rats, Wistar; Receptors, Odorant; Sensitivity and Specificity; Serine | 1998 |
Inhibitory effects of meta-iodo-benzylguanidine (MIBG) on endothelial histamine receptor binding.
Topics: 3-Iodobenzylguanidine; Binding, Competitive; Cells, Cultured; Choline; Cyclic GMP; Cytidine; Endothelium, Vascular; Histamine; Histamine H1 Antagonists; Humans; Inositol; Iodobenzenes; Nitric Oxide; Phospholipids; Propranolol; Pyrilamine; Receptors, Histamine H1; Serine; Umbilical Veins | 1998 |
Synthesis, purification and biological activity of (Ser10-phosphatidyl)-urodilatin (phosphourodilatin).
Topics: Acylation; Amino Acid Sequence; Animals; Aorta; Atrial Natriuretic Factor; Cell Line; Chromatography, High Pressure Liquid; Cyclic GMP; Disulfides; In Vitro Techniques; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Rabbits; Serine; Vasodilation | 1995 |
Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Blood Platelets; Cell Adhesion Molecules; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dichlororibofuranosylbenzimidazole; Epoprostenol; Fluorescent Antibody Technique; Humans; Microfilament Proteins; Nitroprusside; Phosphoproteins; Phosphorylation; Rats; Recombinant Proteins; Serine; Thionucleotides; Transfection | 1998 |
Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress.
Topics: Amino Acid Sequence; Androstadienes; Animals; Calcium; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Stress, Mechanical; Swine; Wortmannin | 2000 |
The amino-terminal cyclic nucleotide binding site of the type II cGMP-dependent protein kinase is essential for full cyclic nucleotide-dependent activation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Conserved Sequence; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type II; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Isoenzymes; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Serine; Spodoptera; Threonine | 2000 |
Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue: a possible mechanism of heterologous desensitization.
Topics: Alanine; Binding Sites; Blotting, Western; Cell Line; Cell Membrane; Cyclic GMP; Detergents; Enzyme Activation; Glutamic Acid; Guanylate Cyclase; Humans; Ligands; Mutagenesis, Site-Directed; Peptide Mapping; Peptides; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Receptors, Atrial Natriuretic Factor; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Biphenyl Compounds; Cell Adhesion Molecules; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hyperlipidemias; In Vitro Techniques; Irbesartan; Microfilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxidative Stress; Phosphoproteins; Phosphorylation; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Serine; Signal Transduction; Superoxide Dismutase; Tetrazoles; Vasodilation; Vasodilator Agents | 2000 |
The destabilization of human GCAP1 by a proline to leucine mutation might cause cone-rod dystrophy.
Topics: Amino Acid Sequence; Animals; Calcium; Calcium-Binding Proteins; Cell Line; Circular Dichroism; Cloning, Molecular; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Escherichia coli; Family Health; Glutamic Acid; Guanylate Cyclase-Activating Proteins; Hot Temperature; Humans; Leucine; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myristic Acids; Phenotype; Proline; Retinitis Pigmentosa; Sequence Homology, Amino Acid; Serine; Temperature | 2001 |
Renal effects of serine-7 analog of lymphoguanylin in ex vivo rat kidney.
Topics: Animals; Cell Line; Cyclic GMP; Female; Glucose; Humans; Kidney; Male; Natriuretic Peptides; Opossums; Peptides; Rats; Rats, Inbred WKY; Serine; Sodium Chloride; Tromethamine | 2001 |
Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Calcium; Colforsin; Culture Techniques; Cyclic GMP; Ileum; Microcystins; Microscopy, Electron; Muscle Proteins; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Kinase; Peptide Fragments; Peptides; Peptides, Cyclic; Phosphorylation; Point Mutation; Rabbits; Serine | 2001 |
Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants.
Topics: Actins; Binding Sites; Blood Platelets; Blotting, Western; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Mitogen-Activated Protein Kinases; Molecular Chaperones; Mutagenesis, Site-Directed; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Thionucleotides; Threonine; Time Factors | 2001 |
Molecular and cellular physiology of the dissociation of atrial natriuretic peptide from guanylyl cyclase a receptors.
Topics: Alanine; Animals; Atrial Natriuretic Factor; Binding, Competitive; Catalysis; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclic GMP; Cytoplasm; Gene Deletion; Glycine; Guanylate Cyclase; Kinetics; Ligands; Mutagenesis, Site-Directed; Mutation; Point Mutation; Protein Binding; Protein Structure, Tertiary; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Serine; Temperature; Time Factors; Transfection | 2001 |
A molecular switch for specific stimulation of the BKCa channel by cGMP and cAMP kinase.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Base Sequence; Cattle; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electrophysiology; Enzyme Activation; Humans; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Models, Biological; Molecular Sequence Data; Muscle, Smooth; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine; Trachea | 2001 |
Serine 331 is the major site of receptor phosphorylation induced by agents that activate protein kinase G in HEK 293 cells overexpressing thromboxane receptor alpha.
Topics: Base Sequence; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA Primers; Enzyme Activation; Fatty Acids, Unsaturated; Glutathione; Humans; In Vitro Techniques; Mutagenesis, Site-Directed; Nitroprusside; Nitroso Compounds; Phosphorylation; Receptors, Thromboxane; Recombinant Fusion Proteins; S-Nitrosoglutathione; Serine | 2001 |
Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Biomarkers; Cell Adhesion Molecules; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Kinetics; Male; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphoproteins; Phosphorylation; Quinoxalines; Rabbits; Serine; Signal Transduction; Thionucleotides | 2002 |
A conserved serine juxtaposed to the pseudosubstrate site of type I cGMP-dependent protein kinase contributes strongly to autoinhibition and lower cGMP affinity.
Topics: Amino Acid Sequence; Animals; Conserved Sequence; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Phosphorylation; Serine; Spodoptera; Structure-Activity Relationship | 2002 |
Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase.
Topics: Adenoviridae; AMP-Activated Protein Kinases; Animals; Arginine; Blotting, Western; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Genes, Dominant; Multienzyme Complexes; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxygen; Peroxynitrous Acid; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Time Factors; Transfection; Up-Regulation; Zinc | 2002 |
Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension.
Topics: Animals; Blotting, Western; Body Weight; Calcium; Carbachol; Cell Membrane; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Golgi Apparatus; HSP90 Heat-Shock Proteins; Hypertension, Pulmonary; Hypoxia; Microscopy, Fluorescence; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Phosphorylation; Precipitin Tests; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Serine; Time Factors | 2002 |
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Heat induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid media.
Topics: Animals; Carotid Artery, Common; Cyclic AMP; Cyclic GMP; Differential Threshold; Heat-Shock Proteins; Histamine; Hot Temperature; HSP20 Heat-Shock Proteins; Isoelectric Point; Muscle, Smooth, Vascular; Myosin Light Chains; Nucleotides, Cyclic; Phosphoproteins; Phosphorylation; Serine; Swine | 2003 |
The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum.
Topics: Alanine; Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Conserved Sequence; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Gene Duplication; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Recombinant Proteins; Serine; Thionucleotides; Threonine | 2003 |
Receptor-controlled phosphorylation of alpha 1 soluble guanylyl cyclase enhances nitric oxide-dependent cyclic guanosine 5'-monophosphate production in pituitary cells.
Topics: Alanine; Amino Acid Substitution; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dimerization; Enzyme Activation; Enzyme Inhibitors; Female; Growth Hormone-Releasing Hormone; Guanylate Cyclase; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland, Anterior; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; Serine; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide | 2004 |
The contribution of serine residues 1588 and 1755 to phosphorylation of the type I inositol 1,4,5-trisphosphate receptor by PKA and PKG.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Calcium Channels; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Mice; Mutagenesis, Site-Directed; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Serine; Transfection | 2004 |
Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells.
Topics: Actins; Animals; Blotting, Western; Cell Movement; Cells, Cultured; Centrifugation; Cloning, Molecular; COS Cells; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cytoplasm; Cytoskeleton; DNA, Complementary; Endothelium, Vascular; Fetal Proteins; Formins; Gene Expression; Gene Library; Glutathione Transferase; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Serine; Transfection; Two-Hybrid System Techniques | 2004 |
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.
Topics: Cell Hypoxia; Cell Line, Tumor; Cyclic GMP; Dose-Response Relationship, Drug; Electrochemistry; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Recombinant Proteins; Serine; Time Factors; Transcription Factors; Tumor Suppressor Protein p53 | 2004 |
The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor.
Topics: Amino Acid Sequence; Calcium; CD3 Complex; Cross-Linking Reagents; Cyclic GMP; Cytoplasm; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Glutathione Transferase; Humans; Inflammation; Isoenzymes; Jurkat Cells; L-Selectin; Lymphocytes; Mass Spectrometry; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-theta; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Threonine | 2004 |
Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
Topics: Animals; Apoptosis Regulatory Proteins; Binding Sites; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic GMP; Death-Associated Protein Kinases; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Male; Models, Biological; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Nucleotides; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Rabbits; Recombinant Proteins; Serine; Threonine; Time Factors | 2004 |
Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries.
Topics: Adult; Aspartic Acid; Cerebral Arteries; Cyclic GMP; Endothelium, Vascular; Epilepsy; Female; Gene Expression; Humans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Point Mutation; Recombinant Proteins; Serine; Vasodilation | 2005 |
Alpha-Tocopherol and endothelial nitric oxide synthesis.
Topics: alpha-Tocopherol; Biopterins; Cells, Cultured; Citrulline; Cyclic GMP; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Serine; Umbilical Veins | 2004 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Osteoblasts; Phosphorylation; Protein Binding; Rats; Recombinant Proteins; Serine; Threonine; Time Factors; Transcriptional Activation | 2005 |
Nitric oxide regulates prolidase activity by serine/threonine phosphorylation.
Topics: Animals; Blotting, Western; Cyclic GMP; Dipeptidases; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Immunoprecipitation; Inflammation; Matrix Metalloproteinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; NIH 3T3 Cells; Nitric Oxide; Nitric Oxide Synthase Type II; Peptides; Phosphorylation; Plasmids; Serine; Signal Transduction; Thiourea; Threonine; Time Factors; Transfection; Wound Healing | 2005 |
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroquinones; Iliac Artery; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Phenylephrine; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinoxalines; Serine; Signal Transduction; Swine; Triazoles; Tyrosine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.
Topics: Adenoviridae; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Half-Life; Humans; Mutation; Ovarian Neoplasms; Oxadiazoles; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Quinoxalines; RNA, Small Interfering; Serine; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G.
Topics: Animals; Calcium Signaling; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diglycerides; Endothelial Cells; Humans; Microfilament Proteins; Models, Biological; Mutation; Nitric Oxide Donors; Penicillamine; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Serine; Tetradecanoylphorbol Acetate; Transfection; TRPC Cation Channels | 2006 |
Csk mediates G-protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity.
Topics: Animals; Atrial Natriuretic Factor; Catalysis; Cell Line; Cell Membrane; CSK Tyrosine-Protein Kinase; Cyclic GMP; Fibroblasts; Gene Expression Regulation; Guanylate Cyclase; Lysophospholipids; Mice; Phosphorylation; Protein-Tyrosine Kinases; Receptors, G-Protein-Coupled; Serine; Signal Transduction; src-Family Kinases; Threonine; Transfection | 2006 |
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.
Topics: alpha-Tocopherol; Animals; Aorta; Cell Adhesion Molecules; Cyclic GMP; Cytochrome P-450 CYP1A2; Down-Regulation; Drug Tolerance; Lipid Peroxidation; Male; Microfilament Proteins; Myocardium; Nitrates; Nitric Oxide; Nitroglycerin; Oxidative Stress; Phosphoproteins; Phosphorylation; Rats; Reactive Oxygen Species; Serine; Vasodilator Agents; Vitamin E; Vitamin E Deficiency | 2006 |
Retinoids restore normal cyclic nucleotide sensitivity of mutant ion channels associated with cone dystrophy.
Topics: Animals; Asparagine; Cattle; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Humans; Ion Channels; Mutation; Oocytes; Patch-Clamp Techniques; Retinitis Pigmentosa; Retinoids; Serine; Transduction, Genetic; Vitamin A; Xenopus | 2006 |
Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant.
Topics: Actins; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chemotaxis; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Interleukin-8; Leukotriene B4; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Serine; Signal Transduction; Tumor Necrosis Factor-alpha | 2007 |
Regulation of endothelial nitric oxide synthase: involvement of protein kinase G 1 beta, serine 116 phosphorylation and lipid structures.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Nucleus; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclodextrins; Cytosol; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Lung; Membrane Lipids; Microcirculation; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroso Compounds; Organelles; Phosphorylation; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Serine; Sheep; Time Factors | 2008 |
Nitric oxide modulates the frog heart ventricle morphodynamics.
Topics: Animals; Anura; Arginine; Cyclic GMP; Female; Heart Ventricles; In Vitro Techniques; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perfusion; Serine; Software; Ventricular Function | 2008 |
Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.
Topics: Animals; Cell Adhesion Molecules; Chlorocebus aethiops; COS Cells; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Feedback, Physiological; Guanylate Cyclase; Kinetics; Microfilament Proteins; Mutation; Nitric Oxide; Peptide Fragments; Phosphoproteins; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Serine; Signal Transduction; Soluble Guanylyl Cyclase; Substrate Specificity; Transfection | 2008 |
Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity.
Topics: Acetylation; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; HeLa Cells; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Serine; Transfection; Young Adult | 2009 |
Ser/Thr/Tyr phosphoproteome analysis of pathogenic and non-pathogenic Pseudomonas species.
Topics: Amino Acids; Bacterial Proteins; Chromatography, Liquid; Cyclic GMP; Mass Spectrometry; Phosphoamino Acids; Phosphopeptides; Phosphorylation; Protein Kinases; Proteome; Pseudomonas aeruginosa; Pseudomonas putida; Serine; Signal Transduction; Threonine; Tyrosine | 2009 |
Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism--the possible key role of PKG.
Topics: Animals; Arachidonic Acid; Calcium; Catalytic Domain; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; In Vitro Techniques; Mice; Mice, Inbred C57BL; Models, Biological; Nerve Degeneration; Nitric Oxide Synthase Type I; Parkinsonian Disorders; PC12 Cells; Phospholipases A2, Cytosolic; Protein Kinase C; Rats; Serine; Signal Transduction; Substantia Nigra | 2009 |
Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell Adhesion Molecules; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heart Rate; Male; Mice; Mice, Knockout; Microfilament Proteins; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nucleotides, Cyclic; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Serine; Soluble Guanylyl Cyclase; Thionucleotides; Time Factors; Up-Regulation | 2009 |
A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cattle; Cell Line; Cyclic GMP; Gene Knockout Techniques; Guanylate Cyclase; Humans; Light; Magnesium; Mice; Mutation; Phosphorylation; Phosphotransferases; Protein Kinases; Protein Phosphatase 2; Receptors, Cell Surface; Rod Cell Outer Segment; Sequence Homology, Amino Acid; Serine | 2010 |
Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebellum; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperammonemia; In Vitro Techniques; Male; Microdialysis; Nitrates; Nitric Oxide Synthase Type I; Nitrites; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Statistics, Nonparametric; Subcellular Fractions; Threonine | 2010 |
Protein kinase G type-Ialpha phosphorylates the apoptosis-regulating protein Bad at serine 155 and protects against apoptosis in N1E-115 cells.
Topics: Apoptosis; bcl-Associated Death Protein; Blotting, Western; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; DNA Fragmentation; Enzyme Activation; Humans; Nitric Oxide; Oxadiazoles; Phosphorylation; Quinoxalines; Recombinant Proteins; Serine | 2010 |
Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway.
Topics: Animals; Aorta; Caveolin 1; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Hindlimb Suspension; HSP90 Heat-Shock Proteins; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Serine; Soluble Guanylyl Cyclase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Weightlessness Simulation | 2010 |
Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase.
Topics: Aged; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; In Vitro Techniques; Male; Mammary Arteries; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2011 |
Dual wavelength photoactivation of cAMP- and cGMP-dependent protein kinase signaling pathways.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fluorescence; Light; Microfilament Proteins; Molecular Probes; Myocytes, Smooth Muscle; Phosphoproteins; Phosphorylation; Photochemical Processes; Rats; Serine; Signal Transduction; Spectrometry, Fluorescence | 2011 |
Activity-dependent regulation of surface glucose transporter-3.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Bicuculline; Biotinylation; Cerebral Cortex; Cyclic GMP; Disks Large Homolog 4 Protein; Dogs; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Gene Expression Regulation; Glucose Transporter Type 3; Green Fluorescent Proteins; Hexoses; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Potassium Channel Blockers; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptosomes; Thionucleotides; Time Factors; Transfection; Valine | 2011 |
Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
Topics: Animals; Antioxidants; Aorta; Biopterins; Catalase; Cyclic GMP; GTP Cyclohydrolase; Hydrogen Peroxide; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Serine; Superoxide Dismutase; Superoxides; Tyrosine | 2011 |
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Freezing Reaction, Cataleptic; Guanosine; Hindlimb Suspension; Immunosuppressive Agents; Male; Mice; N-Methylaspartate; Nitric Oxide; Phosphatidylinositol 3-Kinases; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sirolimus; Swimming; TOR Serine-Threonine Kinases | 2012 |
Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes.
Topics: Animals; Calcium; Cattle; Cyclic GMP; Feedback, Physiological; G-Protein-Coupled Receptor Kinase 1; Gene Expression Regulation; Guanylate Cyclase-Activating Proteins; Leucine; Markov Chains; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Oligopeptides; Phosphorylation; Photic Stimulation; Photons; Retinal Rod Photoreceptor Cells; Rhodopsin; Serine; Signal Transduction; Time Factors | 2012 |
Specific phosphorylation sites underlie the stimulation of a large conductance, Ca(2+)-activated K(+) channel by cGMP-dependent protein kinase.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; HEK293 Cells; Humans; Large-Conductance Calcium-Activated Potassium Channels; Mice; Nitric Oxide; Nitric Oxide Donors; Phosphorylation; Rats; Serine; Signal Transduction | 2013 |
The mediation of platelet quiescence by NO-releasing polymers via cGMP-induced serine 239 phosphorylation of vasodilator-stimulated phosphoprotein.
Topics: Animals; Blood Platelets; Cell Adhesion Molecules; Cyclic GMP; Humans; Materials Testing; Microfilament Proteins; Nitric Oxide; Phosphoproteins; Phosphorylation; Polymers; Rabbits; Serine | 2013 |
A short-term incubation with high glucose impairs VASP phosphorylation at serine 239 in response to the nitric oxide/cGMP pathway in vascular smooth muscle cells: role of oxidative stress.
Topics: Acetophenones; Animals; Antioxidants; Benzophenanthridines; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Glucose; Male; Microfilament Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Zucker; Reactive Oxygen Species; Serine | 2014 |
Phenylephrine activates eNOS Ser 1177 phosphorylation and nitric oxide signaling in renal hypertensive rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Hypertension, Renovascular; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Phenylephrine; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Serine; Signal Transduction; Solubility; Vasoconstriction | 2014 |
Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Heart Ventricles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rabbits; Receptors, Corticotropin-Releasing Hormone; Serine; Signal Transduction; Urocortins | 2014 |
Bidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathways.
Topics: Animals; beta Catenin; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Activators; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Human Umbilical Vein Endothelial Cells; Humans; Mice, Inbred C57BL; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Phosphorylation; Protein Binding; Serine; Signal Transduction | 2014 |
Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A.
Topics: Amino Acid Substitution; Calcitonin Gene-Related Peptide; Catalytic Domain; Cell Line; Cilostazol; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; In Vitro Techniques; Models, Molecular; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Serine; Sildenafil Citrate; Sulfonamides; Sumatriptan; Tetrazoles | 2014 |
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
Topics: Animals; Cyclic GMP; Epiregulin; Female; Granulosa Cells; Guanylate Cyclase; Luteinizing Hormone; Meiosis; Mice; Oocytes; Phosphorylation; Receptors, Atrial Natriuretic Factor; Serine; Sheep; Threonine | 2016 |
PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells.
Topics: Angiotensin II; Aorta; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Serine; Transfection; Up-Regulation | 2016 |
Urothelium muscarinic activation phosphorylates CBS(Ser227) via cGMP/PKG pathway causing human bladder relaxation through H2S production.
Topics: Carbachol; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cystathionine beta-Synthase; Humans; Hydrogen Sulfide; Muscarinic Antagonists; Muscle Contraction; Phosphorylation; Receptors, Muscarinic; Serine; Urothelium | 2016 |
Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells.
Topics: Amino Acid Substitution; Animals; Binding Sites; Chondrocytes; Chondrosarcoma; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type II; Fibroblast Growth Factor 2; MAP Kinase Signaling System; Mutagenesis, Site-Directed; Phosphorylation; Proto-Oncogene Proteins c-raf; Rats; Serine; Signal Transduction; Tumor Cells, Cultured | 2017 |
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like Peptide 2; Indazoles; Male; Methylene Blue; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sildenafil Citrate; Swimming | 2019 |
Protein kinase G phosphorylates the Alzheimer's disease-associated tau protein at distinct Ser/Thr sites.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Aggregates; Rats, Sprague-Dawley; Serine; tau Proteins; Threonine | 2021 |