Compounds > serine

serine and cyc 202

serine has been researched along with cyc 202 in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.78)18.2507
2000's23 (63.89)29.6817
2010's11 (30.56)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Duus, KM; Grose, C; Peng, J; Price, DH; Ye, M1
Ducommun, B; Fernandez, A; Kitzmann, M; Leibovitch, MP; Leibovitch, SA; Meijer, L; Tintignac, LA1
Ball, HM; Blaydes, JP; Craig, AL; Gibbs, NK; Hupp, TR; Traynor, NJ; Wallace, M1
Chen, J; Chen, L; Lu, W; Peng, Y1
Ljungman, M; Paulsen, MT1
Didichenko, SA; Fragoso, CM; Thelen, M1
Ackerley, S; Anderton, BH; Brownlees, J; Grierson, AJ; Leigh, PN; Miller, CC; Shaw, CE; Thornhill, P1
Berven, LA; Boadle, RA; Cousin, MA; Graham, ME; Hansra, G; Jupp, OJ; Larsen, MR; Malladi, CS; McClure, SJ; Robinson, PJ; Sarcevic, B; Tan, TC; Valova, VA1
Bang, YJ; Chae, HD; Choi, KS; Choi, TS; Chung, J; Kim, EH; Mantovani, R; Shin, DY; Yun, J1
Furukawa, K; Hagiwara, M; Horigome, T; Hoshino, S; Ito, H; Koyama, Y; Onogi, H; Takano, M1
Gleeson, JG; Kulkarni, AB; Serneo, FF; Tanaka, T; Tsai, LH; Tseng, HC1
Borchers, CH; Huang, C; Jacobson, K; Schaller, MD1
Dubourg, B; Feunteun, J; Fischer, G; Jahreis, G; Kamphausen, T; Modjtahedi, N; Weiwad, M1
Bäckström, A; Cowburn, RF; Hasslund, K; Jämsä, A; Vasänge, M1
Bontems, S; Di Valentin, E; Habran, L; Piette, J; Sadzot-Delvaux, C1
Agami, R; Duursma, A1
Ranftler, C; Schmitz, ML; Wesierska-Gadek, J1
Gueorguieva, M; Ranftler, C; Wesierska-Gadek, J1
Gueorguieva, M; Herbacek, I; Ranftler, C; Wesierska-Gadek, J1
Abe, T; Liang, S; Matsui, H; Oda, Y; Takei, K; Tanabe, K; Tomizawa, K; Wei, FY; Wu, YM; Yamada, H; Yoshida, Y1
Amin, ND; Chrousos, GP; Garabedian, MJ; Ichijo, T; Kawasaki, E; Kesavapany, S; Kim, N; Kino, T; Pant, HC; Player, A; Rao, S; Wang, Y; Zheng, YL1
Bakke, M; Hansson, ML; Hoivik, EA; Lewis, AE; Rusten, M; Vikse, EL; Wallberg, AE1
Proud, CG; Smith, EM1
Chen, Z; Ginsberg, MH; Huang, C; Jacobson, K; Rajfur, Z; Yousefi, N1
Boeing, S; Eick, D; Heidemann, M; Meisterernst, M; Rigault, C1
Cho, DH; Choi, YJ; Jo, C; Jo, I; Park, JH; Seo, J; Soh, JW1
Fürst, R; Liebl, J; Takács, L; Vereb, G; Vollmar, AM; Weitensteiner, SB; Zahler, S1
Delston, RB; Harbour, JW; Matatall, KA; Onken, MD; Sun, Y1
Gritsch, D; Komina, O; Maurer, M; Węsierska-Gądek, J; Zulehner, N1
Czapski, GA; Gąssowska, M; Radecka, UD; Songin, M; Strosznajder, JB1
Ikari, A; Kurosawa, M; Miwa, M; Sugatani, J; Uchida, T; Yamaguchi, M; Yamazaki, Y1
Adams, CE; Edwards, J; Fyffe, G; Heng, SJ; Horgan, PG; Leung, HY; McCall, P; Seywright, M; Tannahill, C; Underwood, MA; Willder, JM1
Goh, EL; Ming, GL; Ng, T; Ryu, JR; Sohn, JH; Song, H; Tan, T1
Compton, DA; Dmitrovsky, E; Freemantle, S; Godek, K; Hu, S; Kawakami, M; Lu, Y; Mustachio, LM; Orr, B; Sekula, D1
Aprahamian, TR; Farmer, SR; Lin, JZ; Liu, L; Wang, H1
Cloyd, JM; Du, S; Mao, Y; Pawlik, TM; Xiao, Y; Xu, G; Zhang, B1

Other Studies

36 other study(ies) available for serine and cyc 202

ArticleYear
Varicella-zoster virus Fc receptor component gI is phosphorylated on its endodomain by a cyclin-dependent kinase.
    Journal of virology, 1999, Volume: 73, Issue:2

    Topics: Amino Acid Sequence; Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Line, Transformed; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drosophila; Drosophila Proteins; Enzyme Inhibitors; Glutathione Transferase; HeLa Cells; Herpesvirus 3, Human; Humans; Jurkat Cells; Molecular Sequence Data; Phosphorylation; Positive Transcriptional Elongation Factor B; Proline; Protein Serine-Threonine Kinases; Purines; Receptors, Fc; Recombinant Fusion Proteins; Roscovitine; Serine; Threonine; Transfection; Tumor Cells, Cultured; Viral Envelope Proteins

1999
Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells.
    Experimental cell research, 2000, Aug-25, Volume: 259, Issue:1

    Topics: Animals; CDC2-CDC28 Kinases; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Enzyme Inhibitors; Fibroblasts; G1 Phase; Mice; Multienzyme Complexes; Muscle Fibers, Skeletal; Muscle, Skeletal; MyoD Protein; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Purines; Roscovitine; S Phase; Serine; Substrate Specificity; Ubiquitins

2000
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways.
    Oncogene, 2000, Aug-10, Volume: 19, Issue:34

    Topics: Amino Acid Sequence; Cyclin-Dependent Kinases; Dichlororibofuranosylbenzimidazole; DNA Damage; Enzyme Inhibitors; Gene Expression Regulation; Humans; Melanoma; Molecular Sequence Data; Phosphorylation; Purines; RNA Polymerase II; Roscovitine; Serine; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays; X-Rays

2000
Activation of p53 by roscovitine-mediated suppression of MDM2 expression.
    Oncogene, 2001, May-31, Volume: 20, Issue:25

    Topics: Cell Compartmentation; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Humans; Mutation; Nuclear Proteins; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Purines; Roscovitine; Serine; Suppression, Genetic; Tumor Suppressor Protein p53

2001
The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382.
    Molecular pharmacology, 2001, Volume: 60, Issue:4

    Topics: CDC2-CDC28 Kinases; Cell Nucleus; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Lysine; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Purines; RNA Polymerase II; RNA, Messenger; Roscovitine; Serine; Tumor Suppressor Protein p53

2001
Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation.
    The Journal of biological chemistry, 2003, Jul-11, Volume: 278, Issue:28

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Cycle; Cell Division; Class II Phosphatidylinositol 3-Kinases; COS Cells; Cysteine Endopeptidases; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; G2 Phase; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Luminescent Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Mitosis; Molecular Sequence Data; Multienzyme Complexes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Purines; Roscovitine; Serine; Time Factors; Transfection; Tumor Cells, Cultured; Ultraviolet Rays

2003
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.
    The Journal of cell biology, 2003, May-12, Volume: 161, Issue:3

    Topics: Amino Acid Sequence; Animals; Axonal Transport; Axons; Binding Sites; COS Cells; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mutation; Nervous System; Neurofilament Proteins; Phosphorylation; Protein Structure, Tertiary; Purines; Recombinant Fusion Proteins; Roscovitine; Serine

2003
Cdk5 is essential for synaptic vesicle endocytosis.
    Nature cell biology, 2003, Volume: 5, Issue:8

    Topics: Amino Acid Motifs; Animals; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dynamin I; Endocytosis; Enzyme Inhibitors; Monomeric Clathrin Assembly Proteins; Nerve Tissue Proteins; Neurons; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Purines; Rats; Recombinant Fusion Proteins; Roscovitine; Serine; Sheep; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synapses; Synaptic Vesicles; Synaptosomes

2003
Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.
    The Journal of biological chemistry, 2003, Sep-19, Volume: 278, Issue:38

    Topics: Amino Acid Sequence; CCAAT-Binding Factor; CDC2-CDC28 Kinases; Cell Cycle; Cell Line; Cell Nucleus; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dimerization; DNA Damage; Glutathione Transferase; Humans; Molecular Sequence Data; Mutation; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Purines; Roscovitine; Serine; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Protein p53

2003
Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Animals; CDC2 Protein Kinase; Cell Nucleus; Cellulose; Chromatin; DNA; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Lamin B Receptor; Mitosis; Mutation; Oocytes; Peptide Mapping; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Purines; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Roscovitine; S Phase; Serine; Trypsin; Xenopus

2004
Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.
    Neuron, 2004, Jan-22, Volume: 41, Issue:2

    Topics: Animals; Blotting, Western; Cell Movement; Cerebral Cortex; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Doublecortin Domain Proteins; Doublecortin Protein; Humans; Image Processing, Computer-Assisted; Immunoprecipitation; In Situ Hybridization; Mice; Mice, Knockout; Microtubule-Associated Proteins; Microtubules; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Nervous System; Neurons; Neuropeptides; Phenotype; Phosphorylation; Purines; Retroviridae; Roscovitine; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection

2004
Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells.
    The Journal of cell biology, 2004, Feb-16, Volume: 164, Issue:4

    Topics: Animals; Cell Adhesion; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; p38 Mitogen-Activated Protein Kinases; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Purines; Rats; Recombinant Fusion Proteins; Roscovitine; Serine

2004
The human nuclear SRcyp is a cell cycle-regulated cyclophilin.
    The Journal of biological chemistry, 2004, May-21, Volume: 279, Issue:21

    Topics: Amino Acid Sequence; Animals; Arginine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cyclophilins; Cytoplasm; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Humans; Mice; Mitosis; Models, Genetic; Molecular Sequence Data; Peptides; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Purines; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Recombinant Proteins; Roscovitine; Sequence Homology, Amino Acid; Serine; Transfection

2004
The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
    Biochemical and biophysical research communications, 2004, Jul-02, Volume: 319, Issue:3

    Topics: Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Line, Tumor; Cell Size; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Growth Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neurofibrillary Tangles; Phosphorylation; Purines; Roscovitine; Serine; tau Proteins; Tretinoin

2004
Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity.
    The Journal of biological chemistry, 2005, Aug-12, Volume: 280, Issue:32

    Topics: Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Line, Tumor; Chlorocebus aethiops; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cytoplasm; DNA; DNA Mutational Analysis; Down-Regulation; Enzyme Inhibitors; Glutathione Transferase; Herpesvirus 3, Human; Humans; Immediate-Early Proteins; Immunoprecipitation; Mutation; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Purines; Roscovitine; Serine; Threonine; Transfection; Vero Cells; Viral Envelope Proteins

2005
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.
    Molecular and cellular biology, 2005, Volume: 25, Issue:16

    Topics: Anaphase; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Separation; DNA Damage; DNA Replication; Dose-Response Relationship, Radiation; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Humans; Immunoprecipitation; Luciferases; Mice; Models, Biological; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Purines; Roscovitine; Saccharomyces cerevisiae Proteins; Serine; Time Factors; Tumor Suppressor Protein p53

2005
Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells.
    Journal of cellular biochemistry, 2007, Mar-01, Volume: 100, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinases; Enzyme Activation; Humans; Immunoblotting; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine; Serine; Tumor Suppressor Protein p53

2007
Prevention of p53 degradation in human MCF-7 cells by proteasome inhibitors does not mimic the action of roscovitine.
    Annals of the New York Academy of Sciences, 2006, Volume: 1090

    Topics: Cell Cycle; Cell Line, Tumor; Flow Cytometry; Humans; Hydrolysis; Phosphorylation; Protease Inhibitors; Proteasome Inhibitors; Purines; Roscovitine; Serine; Tumor Suppressor Protein p53

2006
Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells.
    Annals of the New York Academy of Sciences, 2007, Volume: 1095

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Doxorubicin; Female; Humans; Phosphorylation; Purines; Roscovitine; Serine; Tumor Suppressor Protein p53

2007
Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis.
    Journal of neurochemistry, 2007, Volume: 102, Issue:5

    Topics: Alanine; Animals; Cyclin-Dependent Kinase 5; Drug Interactions; Endocytosis; Humans; Lipids; Liposomes; Mass Spectrometry; Microscopy, Electron, Scanning; Mutagenesis; Nerve Tissue Proteins; PC12 Cells; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Roscovitine; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Transfection

2007
Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress.
    Molecular endocrinology (Baltimore, Md.), 2007, Volume: 21, Issue:7

    Topics: Animals; Base Sequence; Cell Line; Chlorocebus aethiops; COS Cells; Cyclin-Dependent Kinase 5; Dexamethasone; DNA Primers; Humans; In Vitro Techniques; Ligands; Multiprotein Complexes; Nerve Tissue Proteins; Neurons; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Purines; Rats; Receptors, Glucocorticoid; Recombinant Proteins; Roscovitine; Serine; Stress, Physiological; Transcription, Genetic; Two-Hybrid System Techniques

2007
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:1

    Topics: Acute-Phase Proteins; Amino Acid Sequence; Animals; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chlorocebus aethiops; COS Cells; Cyclin-Dependent Kinases; HeLa Cells; Humans; Immunoprecipitation; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mutation; Phospholipids; Phosphorylation; Protein Binding; Purines; Roscovitine; Serine; Steroidogenic Factor 1; Transcription Factor TFIIH; Transcription Factors; Transfection

2008
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
    The EMBO journal, 2008, Apr-09, Volume: 27, Issue:7

    Topics: Amino Acids; Animals; Biological Assay; CDC2 Protein Kinase; Cell Cycle; Cyclin B; Elongation Factor 2 Kinase; Enzyme Activation; G2 Phase; HeLa Cells; Humans; Leucine; Mice; Mitogen-Activated Protein Kinase 13; Mitosis; Models, Biological; Peptide Elongation Factor 2; Phosphorylation; Protein Kinases; Purines; Roscovitine; Serine; Substrate Specificity; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins

2008
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
    Nature cell biology, 2009, Volume: 11, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cricetinae; Cricetulus; Cyclin-Dependent Kinase 5; Focal Adhesions; Humans; Leupeptins; Mice; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Interaction Domains and Motifs; Pseudopodia; Purines; Rats; Recombinant Proteins; Roscovitine; Serine; Talin; Ubiquitin-Protein Ligases; Ubiquitination

2009
RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion.
    The Journal of biological chemistry, 2010, Jan-01, Volume: 285, Issue:1

    Topics: Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; DNA; HeLa Cells; Humans; Jurkat Cells; Mediator Complex; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Purines; Repetitive Sequences, Amino Acid; RNA Polymerase II; Roscovitine; Serine; Templates, Genetic; Transcription Factor TFIIH; Transcription, Genetic

2010
Cyclin-dependent kinase 5 phosphorylates endothelial nitric oxide synthase at serine 116.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:2

    Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Cyclin-Dependent Kinase 5; DNA, Complementary; Endothelial Cells; Fluorescent Antibody Technique; Gene Expression Regulation; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Probability; Protein Kinase Inhibitors; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; Serine; Signal Transduction; Transfection

2010
Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.
    The Journal of biological chemistry, 2010, Nov-12, Volume: 285, Issue:46

    Topics: Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cells, Cultured; Chick Embryo; Chorioallantoic Membrane; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p27; Endothelial Cells; Female; Humans; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microtubules; Neovascularization, Physiologic; Phosphorylation; Protein Kinase Inhibitors; Purines; RNA Interference; Roscovitine; Serine; Signal Transduction; Umbilical Cord; Vascular Endothelial Growth Factor A

2010
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
    Oncogene, 2011, Feb-03, Volume: 30, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; E2F1 Transcription Factor; Etoposide; Humans; Immunoblotting; Mitogen-Activated Protein Kinase 14; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-mdm2; Purines; Retinoblastoma Protein; RNA Interference; Roscovitine; Serine; Tumor Suppressor Protein p53

2011
Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:4

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drug Synergism; Estrogen Receptor alpha; Flow Cytometry; G2 Phase; HeLa Cells; Humans; Immunoblotting; Membrane Potential, Mitochondrial; Phosphorylation; Protein Kinase Inhibitors; Purines; Roscovitine; Selective Estrogen Receptor Modulators; Serine; Tamoxifen; Time Factors

2011
Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells.
    FEBS letters, 2011, Apr-20, Volume: 585, Issue:8

    Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cell Survival; Cyclin-Dependent Kinase 5; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; PC12 Cells; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Roscovitine; Serine; tau Proteins; Transfection

2011
Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:10

    Topics: Acetylation; Basic Helix-Loop-Helix Transcription Factors; Constitutive Androstane Receptor; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Heat-Shock Proteins; Hep G2 Cells; HSP40 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunoprecipitation; Molecular Chaperones; Mutation; Nuclear Receptor Coactivator 2; Phosphorylation; Pregnane X Receptor; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Transport; Purines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Retinoid X Receptors; Rifampin; RNA Interference; Roscovitine; Serine; Time Factors; Transcriptional Activation; Transfection

2012
Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients.
    British journal of cancer, 2013, Jan-15, Volume: 108, Issue:1

    Topics: Aged; Biomarkers, Tumor; CDC2 Protein Kinase; Disease-Free Survival; Humans; Male; MAP Kinase Signaling System; Phosphorylation; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Purines; Receptors, Androgen; Recurrence; Roscovitine; Serine

2013
Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase 5; Dendrites; Dentate Gyrus; Female; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Hippocampus; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuropilin-1; Neuropilin-2; Phosphorylation; Purines; Rats; Rats, Sprague-Dawley; Retroviridae; RNA, Small Interfering; Roscovitine; Semaphorins; Serine; Signal Transduction; Stem Cells; Tyrosine; Vascular Endothelial Growth Factor A

2013
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:11

    Topics: Anaphase; Animals; Binding Sites; Cell Cycle Proteins; Cell Line, Tumor; Centrosome; Cyclin-Dependent Kinase 2; Cyclins; Humans; Immunoblotting; Lung Neoplasms; Microtubule-Associated Proteins; Mutation; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Purines; RNA Interference; Roscovitine; Serine; Threonine; Ubiquitin Thiolesterase

2015
Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1
    Cell metabolism, 2016, 12-13, Volume: 24, Issue:6

    Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Diet; Energy Metabolism; Flow Cytometry; Gene Expression Regulation; Genome; Glucose Intolerance; Insulin Resistance; Male; Mice, Inbred C57BL; Obesity; Phosphorylation; PPAR gamma; Protective Agents; Purines; RNA, Messenger; Roscovitine; Serine; Thermogenesis; Uncoupling Protein 1

2016
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma.
    Surgical oncology, 2022, Volume: 44

    Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genome-Wide Association Study; Humans; Lapatinib; Pancreatic Neoplasms; Prospective Studies; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); RNA; Roscovitine; Serine; Threonine; Trypsin

2022