serine has been researched along with clozapine in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Cler, JA; Contreras, PC; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Breier, A; Buchanan, RW; Clifton, A; Goldman, D; Malhotra, AK; Ozaki, N; Pickar, D; Rooney, W | 1 |
| Breier, A; Buchanan, RW; Clifton, A; Goldman, D; Kosmidis, MH; Malhotra, AK; Pickar, D; Rooney, W | 1 |
| Chung, LC; Coyle, JT; Tsai, CW; Tsai, GE; Tsai, IC; Yang, P | 1 |
| Einsiedel, J; Gmeiner, P; Hübner, H | 1 |
| Kang, UG; Kim, Y; Kim, YS; Roh, MS; Seo, MS; Yoon, SC | 1 |
| Floresca, CZ; Schetz, JA | 1 |
| Labrie, V; Lipina, T; Roder, J; Weiner, I | 1 |
| Jayathilake, K; Jin, D; Lee, M; Meltzer, HY; Sumiyoshi, T | 1 |
| Blanaru, M; Bloch, B; Ermilov, M; Heresco-Levy, U; Javitt, DC; Kremer, I; Neeman, G | 1 |
| Friedman, AB; Li, X; Rosborough, KM; Roth, KA; Zhu, W | 1 |
| Didriksen, M; Kreilgaard, M; Olsen, CK | 1 |
| Chaki, S; Hashimoto, K; Karasawa, J | 1 |
| Hammonds, MD; Kee, BS; Shim, SS | 1 |
| Ay, ME; Barlas, IO; Basoglu, C; Cetin, M; Erdal, ME; Herken, H; Semiz, UB; Uzun, O | 1 |
| Labrie, V; Lipina, T; Roder, JC | 1 |
| Caselli, G; Chiusaroli, R; Espinoza, S; Garofalo, P; Lanza, M; Neri, E | 1 |
| Huszar, SL; Hutson, PH; McNaughton, CH; Uslaner, JM; Vardigan, JD | 1 |
| Chaki, S; Kaku, A; Shimazaki, T | 1 |
| Motomura, E; Nakagawa, M; Okada, M; Tanahashi, S; Yamamura, S | 1 |
| Cermakova, E; Doubek, P; Hons, J; Libiger, J; Vasatova, M | 1 |
| Hu, Y; Joksimovic, M; Lezama-Ruiz, M; Liu, QS; Liu, SJ; Liu, X; Zhang, Z; Zhong, P | 1 |
| Fujimoto, M; Fujita, Y; Hashimoto, K; Hashimoto, R; Ito, A; Numata, S; Ohi, K; Ohmori, T; Takeda, M; Umeda-Yano, S; Yamamori, H; Yasuda, Y | 1 |
| Chaki, S; Hikichi, H; Kaku, A; Kambe, D; Karasawa, J; Kawaura, K; Kinoshita, K; Koike, H | 1 |
| Aston-Jones, G; Boger, HA; Cass, WA; Fortress, AM; Granholm, AC; Hamlett, ED; Vazey, EM | 1 |
| Liu, D; Mao, S; Peng, Y; Qin, X; Zhang, R; Zhou, X | 1 |
| Fukuyama, K; Murata, M; Okada, M; Okubo, R; Shiroyama, T | 1 |
| Bhattiprolu, AK; Brzustowicz, LM; Clarke, SG; Crosta, CM; Dudzinski, NR; Firestein, BL; Fu, AY; Hernandez, K; Moore, JC; Paradiso, KG | 1 |
| Akkouh, IA; Andreassen, OA; Budinska, E; Djurovic, S; Grabiec, M; Hribkova, H; Kasparek, T; Sun, YM; Szabo, A | 1 |
2 review(s) available for serine and clozapine
| Article | Year |
|---|---|
Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function.
Topics: Animals; Arginine; Aspartic Acid; Binding Sites; Clozapine; Dopamine; Dopamine Antagonists; Haloperidol; Humans; Ligands; Protein Structure, Tertiary; Receptors, Dopamine; Risperidone; Serine | 2004 |
Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site.
Topics: Acetamides; Alanine; Antipsychotic Agents; Clozapine; Cognition; Cycloserine; Dopamine Agents; Drug Synergism; Drug Therapy, Combination; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Humans; Monoamine Oxidase Inhibitors; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Schizophrenic Psychology; Serine | 2008 |
2 trial(s) available for serine and clozapine
| Article | Year |
|---|---|
D-serine added to clozapine for the treatment of schizophrenia.
Topics: Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Glycine; Humans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 1999 |
Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia.
Topics: Adult; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clozapine; Female; Glycine; Humans; Male; Middle Aged; Predictive Value of Tests; Psychiatric Status Rating Scales; Regression Analysis; Schizophrenia; Schizophrenic Psychology; Serine | 2005 |
25 other study(ies) available for serine and clozapine
| Article | Year |
|---|---|
Clozapine attenuates N-methyl-D-aspartate receptor complex-mediated responses in vivo: tentative evidence for a functional modulation by a noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Clozapine; Cyclic GMP; Dioxanes; Haloperidol; Harmaline; Histamine H2 Antagonists; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Methamphetamine; Mice; Norepinephrine; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Ritanserin; Serine; Tropisetron | 1991 |
Clozapine response and the 5HT2C Cys23Ser polymorphism.
Topics: Alleles; Antipsychotic Agents; Base Sequence; Clozapine; Cysteine; DNA Primers; Female; Genetic Carrier Screening; Homozygote; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Predictive Value of Tests; Psychotic Disorders; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Schizophrenia; Serine | 1996 |
The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: a haplotype relative risk study and association with clozapine response.
Topics: Alleles; Antipsychotic Agents; Child; Clozapine; Female; Genetic Carrier Screening; Genotype; Glycine; Haplotypes; Humans; Male; Nuclear Family; Point Mutation; Polymerase Chain Reaction; Receptors, Dopamine D2; Receptors, Dopamine D3; Risk; Schizophrenia; Serine | 1998 |
Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).
Topics: Animals; Biochemistry; Cattle; CHO Cells; Clozapine; Cricetinae; Cysteine; Dopamine Antagonists; Drug Design; Humans; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Molecular Structure; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Threonine | 2001 |
The effects of clozapine on the GSK-3-mediated signaling pathway.
Topics: Apoptosis; beta Catenin; Cell Division; Cell Line, Tumor; Cell Nucleus; Chromones; Clozapine; Culture Media, Serum-Free; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Morpholines; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Time Factors; Trans-Activators; Wnt Proteins; Zebrafish Proteins | 2004 |
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
Topics: Amino Acid Transport Systems, Neutral; Animals; Attention; Clozapine; Conditioning, Psychological; Disease Models, Animal; Dizocilpine Maleate; Glycine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2005 |
Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type.
Topics: Adult; Amino Acids; Antipsychotic Agents; Clozapine; Female; Glycine; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Serine | 2005 |
Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Male; Mice; Mice, Inbred C57BL; Olanzapine; Phosphorylation; Piperazines; Quetiapine Fumarate; Risperidone; Selective Serotonin Reuptake Inhibitors; Serine; Thiazoles; Time Factors | 2007 |
Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Conditioning, Psychological; Dioxoles; Drug Synergism; Isoxazoles; Male; Olanzapine; Paliperidone Palmitate; Piperidines; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Risperidone; Serine; Stereoisomerism | 2006 |
D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Cognition; Cognition Disorders; Dizocilpine Maleate; Exploratory Behavior; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Nootropic Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Sarcosine; Serine; Statistics, Nonparametric | 2008 |
Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients.
Topics: Antipsychotic Agents; Base Sequence; Case-Control Studies; Clozapine; DNA Primers; Glycine; Polymorphism, Genetic; Receptors, Dopamine D3; Schizophrenia; Serine; Turkey | 2009 |
Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
Topics: Animals; Behavior, Animal; Carrier Proteins; Clozapine; Disease Models, Animal; Glycine; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Phenotype; Quinolones; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Sarcosine; Schizophrenia; Schizophrenic Psychology; Serine; Social Behavior; Space Perception | 2008 |
Antipsychotic-like effects of the N-methyl-D-aspartate receptor modulator neboglamine: an immunohistochemical and behavioural study in the rat.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Immunohistochemistry; Male; Motor Activity; Pentanoic Acids; Phencyclidine; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine | 2010 |
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?
Topics: Allosteric Regulation; Animals; Benzamides; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Pyrazoles; Quinine; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Schizophrenia; Serine; Sucrose | 2010 |
D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Social Behavior; Time Factors | 2010 |
Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes.
Topics: Animals; Antipsychotic Agents; Astrocytes; Cells, Cultured; Citrates; Clozapine; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Tetanus Toxin; Tetrodotoxin | 2012 |
Different serine and glycine metabolism in patients with schizophrenia receiving clozapine.
Topics: Adult; Aged; Antipsychotic Agents; Clozapine; Excitatory Amino Acids; Female; Glycine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Serine; Statistics, Nonparametric; Young Adult | 2012 |
Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.
Topics: Animals; Antipsychotic Agents; Clozapine; CREB-Binding Protein; Cyclic AMP; Cyclin-Dependent Kinase 5; Depression; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Food Preferences; Green Fluorescent Proteins; In Vitro Techniques; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Untranslated; Serine; Ventral Tegmental Area | 2014 |
Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment.
Topics: Adult; Antipsychotic Agents; Case-Control Studies; Clozapine; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Schizophrenia; Serine; Stereoisomerism; Treatment Failure | 2014 |
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Glycine; Glycine Plasma Membrane Transport Proteins; Haloperidol; Imipramine; Locomotion; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Serine; Swimming | 2015 |
Designer receptors enhance memory in a mouse model of Down syndrome.
Topics: Animals; Antipsychotic Agents; Cell Count; Clozapine; Cross-Over Studies; Designer Drugs; Disease Models, Animal; Down Syndrome; Exploratory Behavior; Gene Expression Regulation; Humans; Locus Coeruleus; Male; Maze Learning; Memory Disorders; Mice; Mice, Neurologic Mutants; Motor Activity; Neurodegenerative Diseases; Receptor, Muscarinic M3; Serine | 2015 |
Modulation of glycine sites enhances social memory in rats using PQQ combined with d-serine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Drug Contamination; Drug Synergism; Glycine; Haloperidol; Male; Memory; Memory Disorders; Neuroprotective Agents; PQQ Cofactor; Rats; Rats, Sprague-Dawley; Serine; Social Behavior; Time Factors | 2016 |
Activation of Astroglial Connexin is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine.
Topics: Antipsychotic Agents; Astrocytes; Cell Membrane; Clozapine; Connexin 43; Glutamic Acid; Humans; Myocarditis; Schizophrenia; Serine; Valproic Acid | 2020 |
Characterization hiPSC-derived neural progenitor cells and neurons to investigate the role of NOS1AP isoforms in human neuron dendritogenesis.
Topics: Adaptor Proteins, Signal Transducing; Cells, Cultured; Clozapine; Dendrites; Drug Evaluation, Preclinical; Fluphenazine; Gene Expression Regulation; Glutamic Acid; Haloperidol; Humans; Induced Pluripotent Stem Cells; Ion Channels; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Oligopeptides; Patch-Clamp Techniques; Protein Isoforms; Schizophrenia; Serine | 2020 |
Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response.
Topics: Adult; Antipsychotic Agents; Astrocytes; Clozapine; Female; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Male; Middle Aged; Schizophrenia; Serine | 2022 |