serine has been researched along with clavulanic acid in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Frère, JM; Ghuysen, MF; Matagne, A | 1 |
| Aplin, RT; Brown, RP; Schofield, CJ | 1 |
| Giakkoupi, P; Legakis, NJ; Tzelepi, E; Tzouvelekis, LS | 1 |
| Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM | 1 |
| Anderson, VE; Bethel, CR; Bonomo, RA; Buynak, JD; Helfand, MS; Hujer, AM; Liu, Y; Ng, LM; Pagan-Rodriguez, D; Sulton, D; Thomson, JM; Zhou, X | 1 |
| Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Padayatti, PS; Totir, MA; van den Akker, F | 1 |
| Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F | 1 |
| Bonomo, RA; Buynak, JD; Carey, MP; Carey, PR; Helfand, MS; Sheri, A; Totir, MA | 1 |
| Antunes, NT; Champion, MM; Frase, H; Toth, M; Vakulenko, SB | 1 |
| Andersson, I; Blikstad, C; Demetriades, M; Dubus, A; Généreux, C; Hopkinson, RJ; Iqbal, A; Ivison, D; Kershaw, NJ; Lloyd, AJ; McDonough, MA; Roper, DI; Schofield, CJ; Valegård, K | 1 |
| Blok, A; Pannu, NS; Tassoni, R; Ubbink, M | 1 |
| Bokka, A; Desmarais, S; Huckleby, AE; Jeon, J; Kim, SK; Saul, JG; Shin, H | 1 |
12 other study(ies) available for serine and clavulanic acid
| Article | Year |
|---|---|
Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview.
Topics: Actinomycetales; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Clavulanic Acid; Clavulanic Acids; Hydrolysis; Kinetics; Lactams; Serine; Streptomyces; Sulbactam | 1993 |
Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Dithiothreitol; Enzyme Inhibitors; Escherichia coli; Kinetics; Mass Spectrometry; Models, Chemical; Molecular Structure; Penicillanic Acid; Serine; Serine Endopeptidases; Trypsin | 1996 |
Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 beta-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes.
Topics: Amino Acid Substitution; Anti-Bacterial Agents; Arginine; beta-Lactamases; Clavulanic Acid; Cloning, Molecular; Cysteine; Escherichia coli; Microbial Sensitivity Tests; Penicillin Resistance; Serine | 1998 |
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors | 2003 |
Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Chromatography, Liquid; Clavulanic Acid; Drug Resistance, Microbial; Escherichia coli; Glycine; Kinetics; Mass Spectrometry; Microbial Sensitivity Tests; Models, Chemical; Peptides; Serine; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin; Ultraviolet Rays | 2005 |
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.
Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Binding Sites; Clavulanic Acid; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Klebsiella pneumoniae; Models, Chemical; Models, Molecular; Mutation; Penicillanic Acid; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Time Factors; X-Rays | 2005 |
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam | 2007 |
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.
Topics: Acrylates; Amino Acid Substitution; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallization; Enzyme Inhibitors; Imines; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam | 2007 |
Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.
Topics: Anti-Bacterial Agents; Asparagine; beta-Lactamase Inhibitors; beta-Lactamases; Chromatography, Liquid; Clavulanic Acid; Enzyme Inhibitors; Glycine; Microbial Sensitivity Tests; Serine; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2011 |
Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
Topics: Amino Acid Motifs; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carboxypeptidases; Catalytic Domain; Cephalosporins; Clavulanic Acid; Crystallography, X-Ray; Hydrolysis; Models, Molecular; Penicillins; Protein Conformation; Protein Structure, Tertiary; Serine; Streptomyces | 2013 |
New Conformations of Acylation Adducts of Inhibitors of β-Lactamase from Mycobacterium tuberculosis.
Topics: Acylation; Aldehydes; Amino Acid Substitution; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallography, X-Ray; Mycobacterium tuberculosis; Protein Conformation; Serine; Sulbactam; Tazobactam | 2019 |
Development of Hydroxamic Acid Compounds for Inhibition of Metallo-β-Lactamase from
Topics: Anti-Bacterial Agents; Bacillus anthracis; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Hydroxamic Acids; Kinetics; Serine; Zinc | 2022 |