Compounds > serine

serine and alx 1393

serine has been researched along with alx 1393 in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's12 (85.71)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Bauer, I; Braun, S; Hermanns, H; Krug, S; Lipfert, P; Muth-Selbach, U; Werdehausen, R; Williams, R1
Hara, K; Haranishi, Y; Nakamura, S; Sata, T; Terada, T1
Kuraishi, Y; Nishikawa, Y; Sasaki, A1
Jeong, HJ; Vandenberg, RJ; Vaughan, CW1
de Groat, WC; Funahashi, Y; Oguchi, T; Yoshikawa, S; Yoshimura, N1
Cornelis, S; Courade, JP; De Ron, P; Declercq, V; Downey, P; Famelart, M; Ghisdal, P; Jnoff, E; Mingorance-Le Meur, A; Mullier, B; Van Asperen, J; Van Der Perren, C1
Antkowiak, B; Eckle, VS1
Aragon, C; Barthel, F; Bauer, I; Brandenburger, T; Eulenburg, V; Hermanns, H; Schlösser, L; Urban, A; Werdehausen, R1
Dohi, T; Kanematsu, T; Kitayama, T; Morita, K; Motoyama, N; Shiraishi, S; Uezono, Y1
Hara, K; Haranishi, Y; Obara, G; Sata, T; Takahashi, Y; Terada, T1
Iwai, T; Kuraoka, S; Oyama, M; Tanabe, M; Watanabe, S1
Cao, J; Chen, H; Han, F; Hao, X; Huang, Y; Jiang, X; Liu, J; Liu, W; Yang, J; Yin, L; Zhang, H1
Al-Khrasani, M; Balogh, M; Barsi, S; Hajnal, B; Harsing, LG; Király, K; Köles, L; Mohammadzadeh, A; Zádori, ZS1
Aragón, C; Benito-Muñoz, C; Felipe, R; López-Corcuera, B; Núñez, E; Pérez-Siles, G; Perona, A1

Reviews

1 review(s) available for serine and alx 1393

ArticleYear
Glycine transporter inhibitors: A new avenue for managing neuropathic pain.
    Brain research bulletin, 2019, Volume: 152

    Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Neuralgia; Neuroglia; Neurons; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord Dorsal Horn; Synapses; Synaptic Transmission

2019

Other Studies

13 other study(ies) available for serine and alx 1393

ArticleYear
Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain.
    Neuroscience letters, 2008, Nov-21, Volume: 445, Issue:3

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Glycine Plasma Membrane Transport Proteins; Injections, Spinal; Male; Pain Measurement; Rats; Reaction Time; Sarcosine; Sciatica; Serine

2008
The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Acute Disease; Analgesics; Animals; Dose-Response Relationship, Drug; Glycine Plasma Membrane Transport Proteins; Injections, Spinal; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Serine; Strychnine

2010
Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain.
    Journal of pharmacological sciences, 2010, Volume: 112, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Glycine Plasma Membrane Transport Proteins; Herpes Simplex; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Physical Stimulation; Serine

2010
N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
    British journal of pharmacology, 2010, Volume: 161, Issue:4

    Topics: Animals; Arachidonic Acids; Glycine; Inhibitory Postsynaptic Potentials; Miniature Postsynaptic Potentials; N-Methylaspartate; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sarcosine; Serine; Spinal Cord; Synaptic Transmission

2010
Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats.
    European urology, 2012, Volume: 62, Issue:4

    Topics: Animals; Diterpenes; Female; Freezing Reaction, Cataleptic; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Nociceptive Pain; Pain; Rats; Rats, Sprague-Dawley; Sarcosine; Serine; Spinal Cord; Strychnine; Urinary Bladder, Overactive; Urination

2012
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
    British journal of pharmacology, 2013, Volume: 170, Issue:5

    Topics: Analgesics; Animals; Benzamides; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Humans; Membrane Potentials; Mice; Pain; Pain Measurement; Pain Threshold; Serine; Transfection; Xenopus laevis

2013
ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn.
    Neuroscience, 2013, Dec-03, Volume: 253

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Anterior Horn Cells; Biophysical Phenomena; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nerve Net; Organ Culture Techniques; Patch-Clamp Techniques; Serine; Spinal Cord; Time Factors; Valine

2013
Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.
    Anesthesiology, 2014, Volume: 121, Issue:1

    Topics: Animals; Behavior, Animal; Blotting, Western; Constriction, Pathologic; Dose-Response Relationship, Drug; Glycine Plasma Membrane Transport Proteins; Hyperalgesia; Male; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Spinal Cord

2014
Relief of cancer pain by glycine transporter inhibitors.
    Anesthesia and analgesia, 2014, Volume: 119, Issue:4

    Topics: Animals; Benzamides; Bone Neoplasms; Cell Line, Tumor; Drug Therapy, Combination; Glycine Plasma Membrane Transport Proteins; Male; Mice; Mice, Inbred C3H; Pain Management; Pain Measurement; Serine

2014
Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 130

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine Plasma Membrane Transport Proteins; Hyperalgesia; Inflammation; Infusions, Intraventricular; Male; Neuralgia; Pain; Pain Measurement; Rats; Rotarod Performance Test; Serine; Strychnine

2015
Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice.
    Journal of pharmacological sciences, 2017, Volume: 133, Issue:3

    Topics: Animals; Glycine Plasma Membrane Transport Proteins; Inhibitory Postsynaptic Potentials; Male; Mice; Posterior Horn Cells; Sarcosine; Serine

2017
ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway.
    Journal of experimental & clinical cancer research : CR, 2017, Nov-28, Volume: 36, Issue:1

    Topics: beta Catenin; Breast Neoplasms; Disease Progression; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Female; Fluorenes; Humans; Hydantoins; Serine; Transcription Factors; Wnt Signaling Pathway

2017
Structural Determinants of the Neuronal Glycine Transporter 2 for the Selective Inhibitors ALX1393 and ORG25543.
    ACS chemical neuroscience, 2021, 06-02, Volume: 12, Issue:11

    Topics: Animals; Benzamides; Drosophila melanogaster; Glycine Plasma Membrane Transport Proteins; Neurons; Serine

2021