serine has been researched along with alpha-chymotrypsin in 227 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 179 (78.85) | 18.7374 |
| 1990's | 21 (9.25) | 18.2507 |
| 2000's | 19 (8.37) | 29.6817 |
| 2010's | 7 (3.08) | 24.3611 |
| 2020's | 1 (0.44) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, Y; Hata, T; Hayashi, R | 1 |
| Brayer, GD; Delbaere, LT; James, MN | 2 |
| Cohen, P; Rylatt, DB | 1 |
| Davidson, EA; Wusteman, FS | 1 |
| Fredrickson, DS; Herbert, PN; Shulman, RS; Wehrly, K | 1 |
| Poste, G | 1 |
| Botstein, D; Brandriss, MC; Sherman, F; Stewart, JW | 1 |
| Bingham, EW; Traugh, JA; Tuazon, PT | 1 |
| Brinigar, WS; Chao, TL | 1 |
| Chen, R; Gorenstein, DG; Kennedy, WP; Lowe, G; Nurse, D; Schultz, RM | 1 |
| Manavalan, P; Ponnuswamy, PK; Srinivasan, AR | 1 |
| Anderson, WF; Katunuma, N; Kobayashi, K; Matthews, BW; Neurath, H; Titani, K; Woodbury, RG | 1 |
| Aoki, N; Naito, K; Yoshida, N | 1 |
| Ikenaka, T; Odani, S | 1 |
| Belitz, HD; Ortanderl, H | 1 |
| Akhtar, M; Merry, AH; Munday, KA; Penning, TM | 1 |
| Scofield, RE; Werner, RP; Wold, F | 1 |
| Glimcher, MJ; Seyer, JM | 1 |
| Gupton, BF; Powers, JC | 1 |
| Coan, CR; Deranleau, DA; Hinman, LM | 1 |
| Carrell, RW; Chua, CG; Exner, T; Kronenberg, H; Lee, KM; Robin, H; Wilkinson, T | 1 |
| de Haën, C; Neurath, H; Teller, DC | 1 |
| Patthy, L; Smith, EL | 1 |
| Delbaere, LT; Hutcheon, WL; James, MN; Thiessen, WE | 1 |
| Imamura, A; Nagata, C; Umeyama, H | 2 |
| Bizzozero, SA; Zweifel, BO | 1 |
| Kerr, MA; Neurath, H; Walsh, KA | 1 |
| Affleck, R; Clark, DS; Haynes, CA | 1 |
| Tomkinson, B; Zetterqvist, O | 1 |
| Davies, SP; Hardie, DG; Sim, AT | 1 |
| Kula, MR; Schwarz, A; Steinke, D; Wandrey, C | 1 |
| Campbell, DG; Cohen, P; Dent, P; Hubbard, MJ | 1 |
| Abeles, RH; Gelb, MH; Mottonen, JM; Ringe, D | 1 |
| Heldin, P; Humble, E | 1 |
| De Schryver, FC; Desie, G; Van Deynse, D | 1 |
| Castellani, L; Cohen, C; Elliott, BW | 1 |
| Adachi, H; Ishino, F; Matsuhashi, M; Matsuzawa, H; Ohta, T; Takasuga, A | 1 |
| Bowers, B; Côté, GP; Korn, ED; Kuznicki, J | 1 |
| Flemming, HW; Horner, L | 1 |
| Allen, RG; Barrett, JT | 1 |
| Bauer, CA; Löfqvist, B | 1 |
| Kluh, I; Soliman, MH | 1 |
| Barnett, DR; Bowman, BH; Kurosky, A; Lee, TH; Rasco, MA | 1 |
| Groskopf, WR; Hsieh, B; Robbins, KC; Summaria, L | 1 |
| Davie, EW; Ericsson, LH; Fujikawa, K; Hermodson, MA; Neurath, H; Titani, K; Walsh, KA | 1 |
| Cohen, AB | 1 |
| Hsia, JC; Kosman, DJ; Piette, LH | 2 |
| Broomfield, CA; Hackley, BE; Morrisett, JD | 1 |
| Grosclaude, F; Mercier, JC; Ribadeau-Dumas, B | 1 |
| Kosman, DJ | 1 |
| Broomfield, CA; Morrisett, JD | 1 |
| Brown, WE; Wold, F | 2 |
| Kosman, DJ; Piette, LH | 1 |
| Margoliash, E; Putterman, GJ; Sherman, F | 1 |
| Baker, HN; Gotto, AM; Jackson, RL; Morrisett, JD; Sparrow, JT; Taunton, OD | 1 |
| Birktoft, JJ; Blow, DM; Henderson, R; Steitz, TA | 1 |
| Hartley, BS | 3 |
| Filner, B; Marcus, A | 1 |
| Konovessi-Panayotatos, A; Schultz, RM; Treadway, WJ | 1 |
| Asbóth, B; Polgár, L | 1 |
| Carson, JH; Gerber, AC; Hadorn, B | 1 |
| Morihara, K; Oka, T; Tsuzuki, H | 1 |
| Apell, G; Carr, WR; Huisman, TH; Schroeder, WA; Shelton, JB; Shelton, JR; Smith, LL | 1 |
| Hofmann, T; Kurosky, A | 1 |
| Ako, H; Foster, RJ; Ryan, CA | 2 |
| Morihara, K | 1 |
| Awad, WM; Bernstrom, GG; Ochoa, MS; Siegel, S; Skiba, WE; Soto, AR | 1 |
| Awad, WM; Brady, AH; Siegel, S | 1 |
| Blow, DM; Hess, GP; Wright, CS | 1 |
| Hayashi, H; Iwai, K | 1 |
| Cruickshank, WH; Kaplan, H | 1 |
| Polgár, L | 1 |
| Béchet, JJ; Dupaix, A; Robert, JC; Vilkas, M; Wakselman, M; Yon, J | 1 |
| Hugli, TE | 1 |
| Harrap, BS; Heidemann, ER; Schiele, HD | 1 |
| Mani, NV; Morimoto, CN; Tulinsky, A; Vandlen, RL; Wright, LH | 1 |
| Tulinsky, A; Vandlen, RL | 1 |
| Berezin, IV; Kazanskaya, NF; Klyosov, AA; Svedas, VK | 1 |
| Arkhipova, SF; Lipkind, GM; Popov, EM | 1 |
| Bahl, OP; Carlsen, RB; Swaminathan, N | 1 |
| Keil, B; Keil-Dlouha, V | 1 |
| Chen, BL; Poljak, RJ | 1 |
| Parker, L; Tuma, J | 1 |
| Iwanaga, S; Konishi, K; Mikuni, Y; Nakamura, S; Suzuki, T | 1 |
| Ainslie, GR; Barritt, LC; Neet, KE; Sackrison, KM | 1 |
| Stroud, RM | 1 |
| Robillard, G; Shulman, RG | 1 |
| Amidon, GL | 1 |
| Milstein, CP | 1 |
| Arnold, RL; Kakade, ML; Liener, IE; Waibel, PE | 1 |
| Christomanos, AA; Dimitriades, A | 1 |
| Degani, Y; Patchornik, A; Spande, TF; Witkop, B | 1 |
| Jörnvall, H | 2 |
| Hardman, JK; Myers, JS | 1 |
| Arimura, A; Baba, Y; Matsuo, H; Nair, RM; Schally, AV | 1 |
| Glazer, AN | 1 |
| Morihara, K; Tsuzuki, H | 1 |
| Coan, MH; Roberts, RC; Travis, J | 1 |
| Hubbard, CD; Kirsch, JF | 1 |
| Dure, LS; Ihle, JN | 1 |
| Liener, IE; Seidl, DS | 1 |
| Powers, JC; Robillard, GT; Wilcox, PE | 1 |
| Krahn, J; Stevens, FC | 1 |
| Ward, CW | 1 |
| Bresler, SE; Krutyakov, VM; Vlasov, GP | 1 |
| Gratecos, D; Shaw, MC | 1 |
| Cohen, GH; Davies, DR; Powers, JC; Segal, DM; Wilcox, PE | 1 |
| Henderson, R | 1 |
| Belke, CJ; Shafer, JA; Su, SC | 1 |
| Furka, A | 1 |
| Erlanger, BF | 1 |
| Barnard, EA; Kawiak, J; Komender, J; Vensel, WH | 1 |
| Blow, DM; Henderson, R; Steitz, TA | 1 |
| Moriya, H; Yamazaki, K | 1 |
| Hartley, BS; Shotton, DM | 1 |
| Brydon, SE; Neet, KE | 1 |
| Cramer, F; Mackensen, G | 1 |
| Behnke, WD; Neurath, H; Wade, RD | 1 |
| Baker, BR; Cardinaud, R | 1 |
| Doolittle, RF; Mross, GA; Roberts, BF | 1 |
| Blow, DM; Steitz, TA | 1 |
| Galizzi, A | 1 |
| Houston, M; Viswanatha, T | 1 |
| Becker, EL | 1 |
| Koehler, KA; Lienhard, GE | 1 |
| Fersht, AR | 1 |
| Hexter, CS; Westheimer, FH | 1 |
| Feldbau, E; Schwabe, C | 1 |
| Miyatake, A; Wada, H; Watanabe, T | 1 |
| Bernini, LF; de Jong, WW; Meera Khan, P | 1 |
| Fife, TH; Milstein, JB | 1 |
| Busch, H; Roth, C; Sautiere, P; Starbuck, WC | 1 |
| Bonner, J; DeLange, RJ; Fambrough, DM; Smith, EL | 1 |
| Magnusson, S | 1 |
| Indada, Y; Matsushima, A; Nomoto, M; Sakurai, K; Shibata, K | 1 |
| Blow, DM; Henderson, R; Matthews, BW; Sigler, PB | 1 |
| Alden, RA; Kraut, J; Wright, CS | 1 |
| Birktoft, JJ; Blow, DM; Hartley, BS | 1 |
| Kaplan, H; Whitaker, DR | 1 |
| Belleau, B; DiTullio, V; Godin, D | 1 |
| Baronowsky, P; Finn, F; Laursen, R; Shafer, J; Westheimer, FH | 1 |
| Hoare, DG; Koshland, DE; Weiner, H; White, WN | 1 |
| Richmond, V | 1 |
| Hartley, BS; Smillie, LB | 1 |
| Engström, L; von Hofsten, B; Wählby, S | 1 |
| Brocklehurst, K; Williamson, K | 1 |
| Roy, C; Whitaker, DR | 1 |
| Blout, ER; Laufer, DA | 1 |
| Smillie, LB; Whitaker, DR | 1 |
| Kegeles, G; Morimoto, K | 1 |
| Antonini, E; Ascenzi, P; Bolognesi, M; Gatti, G; Guarneri, M; Menegatti, E | 1 |
| Abeles, RH; Westkaemper, RB | 1 |
| Lawson, WB | 1 |
| Ashe, BM; Frankshun, R; Jones, H; Morman, H; Mulvey, D; Zimmerman, M | 1 |
| Andersson, L; Wolfenden, R | 1 |
| Angelides, KJ | 1 |
| Kolattukudy, PE; Poulose, AJ; Rogers, L | 1 |
| Genest, M; Ptak, M | 1 |
| Trudelle, Y | 1 |
| Arnold, SF; Jaffe, H; Notides, AC; Obourn, JD | 1 |
| Frey, PA; Tobin, JB; Whitt, SA | 1 |
| Cheng, X; Kovac, L; Lee, JC | 1 |
| Beach, CM; Cai, AL; Darzynkiewicz, E; Joshi, B; Keiper, BD; Mendez, R; Minich, WB; Rhoads, RE; Stepinski, J; Stolarski, R | 1 |
| Bateman, RC | 1 |
| Kurosky, A; Miller, BT; Rogers, ME; Smith, JS | 1 |
| Gething, MJ; Goldsmith, EJ; Kobe, A; Madison, EL; Sambrook, JF | 1 |
| Bachovchin, WW; Kettner, CA; Tsilikounas, E | 1 |
| Kornstädt, U; Lührmann, R; Manley, JL; Will, CL; Woppmann, A; Zuo, P | 1 |
| Carrell, RW; Finch, JT; Lomas, DA; Nukiwa, T; Seyama, K | 1 |
| Cornell, RB; Veitch, DP | 1 |
| Blow, DM | 1 |
| Craik, CS; Perona, JJ | 1 |
| McGrath, ME; Mirzadegan, T; Schmidt, BF | 1 |
| Eger, BT; Hynes, RC; Jones, JB; Martichonok, V; Pai, EF; Stoll, VS | 1 |
| Dahlen, JR; Foster, DC; Kisiel, W | 1 |
| Takeda-Shitaka, M; Umeyama, H | 1 |
| Aoki, K; Campbell, LR; Hull, RJ; Lee, JY; Lucas, WJ; Monzer, J; Ullman, DE; Xiang, Y; Xoconostle-Cázares, B; Yoo, BC | 1 |
| Belova, LA | 1 |
| Crews, CM; Dantuma, NP; Kim, KB; Lindsten, K; Myung, J | 1 |
| Kaneko, I; Kubo, T; Morimoto, K | 1 |
| Cope, LD; Fink, DL; Geme, JW; Hansen, EJ | 1 |
| Barrette-Ng, IH; Cherney, MM; Garen, C; Gorbalenya, AE; James, MN; Kolodenko, Y; Mark, BL; Ng, KK; Snijder, EJ; Van Aken, D | 1 |
| Erikson, RL; Jang, YJ; Ma, S; Terada, Y | 1 |
| Bryson, S; Chang, X; Datti, A; Lew, AM; Macher, BA; Takeshita, S; Tse, R; Tvaroska, I; Yen, TY | 1 |
| MAY, SC; SCHAFFER, NK; SUMMERSON, WH | 1 |
| GUNDLACH, G; TURBA, F | 1 |
| BENOITON, L; COHEN, JA; OOSTERBAAN, RA; RYDON, HN; VAN ADRICHEM, ME | 1 |
| KOSHLAND, DE; RAY, WJ; STRUMEYER, DH | 1 |
| KOSHLAND, DE | 2 |
| KOSHLAND, DE; STRUMEYER, DH; WHITE, WN | 1 |
| RIESER, CH; RIESER, P | 1 |
| KALLOS, J; RIZOK, D | 1 |
| HENDERSON, LE; STEVENS, CO; TOLBERT, BM | 1 |
| GUEST, JR; YANOFSKY, C | 1 |
| LIENER, IE; TRAVIS, J | 1 |
| RIESER, P | 1 |
| GOLD, AM | 1 |
| ENGELHARDT, DL; KONIGSBERG, W; NOTANI, GW; ZINDER, ND | 1 |
| ENGLE, RR; HARSHMAN, S; SCHAFFER, NK | 1 |
| Botos, I; Cherry, S; Dauter, Z; Gustchina, A; Khalatova, AG; Maurizi, MR; Melnikov, EE; Rasulova, F; Rotanova, TV; Tropea, JE; Wlodawer, A | 1 |
| Lerchner, A; Rücknagel, KP; Saleemuddin, M; Schierhorn, A; Schöps, R; Ulbrich-Hofmann, R; Younus, H | 1 |
| Antal, J; Gráf, L; Jelinek, B; Venekei, I | 1 |
| Jackson, CM; Shi, F; Winzor, DJ | 1 |
| Dellos, SR; Klein, KC; Lingappa, JR | 1 |
| Bajaj, SP; Cascio, D; Chand, HS; Kisiel, W; Schmidt, AE | 1 |
| Furukawa, K; Hirano, Y; Horigome, T; Ouchi, FS; Segawa, M; Takeyasu, K; Yamakawa, Y | 1 |
| Akhtar, MS; Bhakuni, V; Mishra, P | 1 |
| Bernkop-Schnürch, A; Kafedjiiski, K; Kolmar, H; Werle, M | 1 |
| Cosgrove, S; Hewage, C; Malthouse, JP; Rogers, L; Spink, E | 1 |
| Bargagna-Mohan, P; Ho, YK; Kim, KB; Mohan, R; Wehenkel, M | 1 |
| Manithody, C; Qureshi, SH; Rezaie, AR; Yang, L | 1 |
| McLeish, MJ; Pratt, RF | 1 |
| Howe, N; Malthouse, JP; O'Donohoe, CA; Petrillo, T | 1 |
| Ahn, H; Choi, MS; Chun, HS; Kim, CS; Kim, DK; Kim, HJ; Kim, JJ; Kim, JS; Kim, SG; Kim, YH; Lee, SY; Moon, SM; Park, BR; Seo, YW; Shin, YK | 1 |
| Cleary, JA; Doherty, W; Evans, P; Malthouse, JP | 1 |
| Carrilho, FJ; da Costa, MZ; Ferreira, Cda S; Guarita, DR; Nasser, PD; Ono, SK; Paranaguá-Vezozzo, DC; Pires, JG; Teixeira, AC | 1 |
| Goel, P; Hubalek, M; Jumpertz, T; Mikles, DC; Ogorek, I; Pietrzik, CU; Schmidt, B; Strisovsky, K; Tichá, A; Weggen, S | 1 |
| Bass, C; Dias, RO; Hunt, BJ; Silva-Filho, MC; Souza, TP; Velasquez-Vasconez, PA | 1 |
5 review(s) available for serine and alpha-chymotrypsin
| Article | Year |
|---|---|
The active centers of serine proteinases.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Cattle; Chymotrypsin; Chymotrypsinogen; Endopeptidases; Histidine; Hydrogen-Ion Concentration; Kinetics; Protein Binding; Protein Conformation; Serine; Solubility; X-Ray Diffraction | 1974 |
[Binding sites of subtilisin].
Topics: Amino Acid Sequence; Bacillus subtilis; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Ketones; Models, Chemical; Peptides; Serine; X-Ray Diffraction | 1972 |
Selective cleavage and modification of peptides and proteins.
Topics: Alanine; Aspartic Acid; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Glutamates; Glycine; Hydrogen-Ion Concentration; Methionine; Muramidase; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Proteins; Pyrrolidines; Ribonucleases; Serine; Succinates; Threonine; Tryptophan | 1970 |
Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.
Topics: Aspartic Acid; Binding Sites; Chymotrypsin; Histidine; Lysine; Protein Conformation; Serine; Serine Endopeptidases; Structure-Activity Relationship; Substrate Specificity; Trypsin | 1997 |
Angiotensin II-generating enzymes.
Topics: Angiotensin II; Angiotensinogen; Animals; Cathepsin G; Cathepsins; Chymases; Chymotrypsin; Humans; Hydrogen-Ion Concentration; Models, Biological; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Serine; Serine Endopeptidases; Tissue Kallikreins | 2000 |
222 other study(ies) available for serine and alpha-chymotrypsin
| Article | Year |
|---|---|
Further confirmation of carboxypeptidase Y as a metal-free enzyme having a reactive serine residue.
Topics: Apoenzymes; Binding Sites; Carboxypeptidases; Cations, Divalent; Cations, Monovalent; Chymotrypsin; Dialysis; Diuron; Edetic Acid; Hydrogen-Ion Concentration; Iron; Kinetics; Metals; Protein Binding; Protein Conformation; Saccharomyces cerevisiae; Serine; Trypsin Inhibitors | 1975 |
Amino acid sequence alignment of bacterial and mammalian pancreatic serine proteases based on topological equivalences.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chymotrypsin; Enzyme Precursors; Models, Molecular; Pancreas; Pancreatic Elastase; Peptide Hydrolases; Pronase; Protein Conformation; Serine; Streptomyces griseus | 1978 |
Amino acid sequence at the site on rabbit skeletal muscle glycogen synthase phosphorylated by the endogenous glycogen synthase kinase-2 activity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chymotrypsin; Glycogen Synthase; Muscles; Peptide Fragments; Phosphorylation; Protein Kinases; Rabbits; Serine; Trypsin | 1979 |
The 2.8 A resolution structure of Streptomyces griseus protease B and its homology with alpha-chymotrypsin and Streptomyces griseus protease A.
Topics: Amino Acid Sequence; Binding Sites; Chymotrypsin; Endopeptidases; Models, Molecular; Protein Conformation; Serine; Streptomyces griseus | 1979 |
The linkage region in the polypeptide of pig costal cartilage proteoglycan.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cartilage; Chondroitin; Chondroitin Sulfates; Chymotrypsin; Glycosaminoglycans; Molecular Weight; Peptides; Protein Conformation; Proteoglycans; Serine; Swine; Trypsin; Xylose | 1975 |
Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Apoproteins; Carboxypeptidases; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Thin Layer; Chymotrypsin; Cyanogen Bromide; Dansyl Compounds; Humans; Hyperlipidemias; Lipoproteins, VLDL; Peptide Fragments; Peptide Hydrolases; Serine; Trypsin | 1975 |
Production of a serine-protease with macrophage migration-inhibitory factor activity by virus-transformed cells and human tumor cell lines.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Migration Inhibition; Cell Transformation, Neoplastic; Cell-Free System; Chymotrypsin; Cricetinae; Endopeptidases; HeLa Cells; Hot Temperature; Humans; Isoflurophate; Lymphocytes; Macrophage Migration-Inhibitory Factors; Macrophages; Mice; Mice, Inbred BALB C; Neoplasms; Polyomavirus; Serine; Simian virus 40; Trypsin Inhibitors | 1975 |
Substitution of serine caused by a recessive lethal suppressor in yeast.
Topics: Chromosome Mapping; Chymotrypsin; Cytochromes c1; Genes, Lethal; Genes, Recessive; Genotype; Haploidy; Heterozygote; Mutation; Peptide Fragments; Saccharomyces cerevisiae; Serine; Species Specificity; Suppression, Genetic; Trypsin | 1976 |
Cyclic nucleotide-independent protein kinases from rabbit reticulocytes. Site-specific phosphorylation of casein variants.
Topics: Amino Acid Sequence; Amino Acids; Animals; Caseins; Chymotrypsin; Cyclic AMP; Peptide Fragments; Phosphorylation; Protein Kinases; Rabbits; Reticulocytes; Serine; Substrate Specificity; Threonine | 1979 |
Is the serine protease "charge relay system" a charge relay system?
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Chymotrypsinogen; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Peptide Hydrolases; Protein Binding; Protein Conformation; Serine | 1975 |
Evidence for hemiacetal formation between N-acyl-L-phenylalaninals and alpha-chymotrypsin by cross-saturation nuclear magnetic resonance spectroscopy.
Topics: Acetals; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Magnetic Resonance Spectroscopy; Phenylalanine; Protein Binding; Serine; Structure-Activity Relationship; Substrate Specificity | 1979 |
Solvent accessibilities in glycyl, alanyl and seryl dipeptides.
Topics: Alanine; Chymotrypsin; Dipeptides; Glycine; Hydrogen Bonding; Models, Chemical; Muramidase; Protein Conformation; Serine; Solvents | 1977 |
Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine.
Topics: Amino Acid Sequence; Amino Acids; Animals; Apoenzymes; Binding Sites; Biological Evolution; Chymotrypsin; Disulfides; Endopeptidases; Intestine, Small; Peptide Fragments; Pyridoxal Phosphate; Rats; Serine; Serine Endopeptidases; Trypsin; X-Ray Diffraction | 1978 |
Inhibition of platelet aggregation by protease inhibitors. Possible involvement of proteases in platelet aggregation.
Topics: Arachidonic Acids; Chymotrypsin; Humans; Malondialdehyde; Platelet Aggregation; Protease Inhibitors; Serine; Thrombin; Trypsin; Trypsin Inhibitors | 1978 |
Studies on soybean trypsin inhibitors. IV. Change of the inhibitory activity of Bowman-Birk inhibitor upon replacements of the alpha-chymotrypsin reactive site serine residue by other amino acids.
Topics: Alanine; Binding Sites; Chymotrypsin; Glycine; Leucine; Serine; Structure-Activity Relationship; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors; Valine | 1978 |
[Inhibitors for trypsin and chymotrypsin in seeds of the broad bean (Vicia faba) (author's transl)].
Topics: Chymotrypsin; Plants, Edible; Protease Inhibitors; Serine; Trypsin Inhibitors | 1977 |
Studies on the biosynthesis, assembly and secretion of vitellogenin, an oestrogen-induced multicomponent protein.
Topics: Animals; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Leucine; Lipoproteins; Microsomes, Liver; Molecular Weight; Peptides; Phosvitin; Protein Precursors; Serine; Trypsin; Vitellogenins; Xenopus | 1977 |
P-Nitrophenyl carbamates as active-site-specific reagents for serine proteases.
Topics: Affinity Labels; Binding Sites; Carbamates; Chemical Phenomena; Chemistry; Chymotrypsin; Chymotrypsinogen; Endopeptidases; Half-Life; Indicators and Reagents; Pancreatic Elastase; Protease Inhibitors; Serine; Structure-Activity Relationship; Trypsin Inhibitors | 1977 |
Isolation, characterization and partial amino acid sequence of a phosphorylated polypeptide (E4) from bovine embryonic dental enamel.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cattle; Chymotrypsin; Cyanogen Bromide; Dental Enamel Proteins; Embryo, Mammalian; Female; Molecular Weight; Organophosphorus Compounds; Peptide Fragments; Peptides; Phosphoproteins; Pregnancy; Serine; Trypsin | 1977 |
Reaction of serine proteases with aza-amino acid and aza-peptide derivatives.
Topics: Amino Acids; Aza Compounds; Chymotrypsin; Kinetics; Mathematics; Pancreatic Elastase; Peptide Hydrolases; Peptides; Serine | 1977 |
Flexibility in the specificity site of serine proteases.
Topics: Animals; Binding Sites; Cattle; Chymotrypsin; Energy Transfer; Kinetics; Ligands; Mathematics; Peptide Hydrolases; Protein Binding; Protein Conformation; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Trypsin; Trypsinogen; Tryptophan | 1976 |
Haemoglobin Camperdown beta104(G6) arginine leads to serine.
Topics: Adult; Amino Acid Sequence; Amino Acids; Arginine; Australia; Chymotrypsin; Diphosphoglyceric Acids; Female; Genotype; Hemoglobins, Abnormal; Humans; Kinetics; Male; Middle Aged; Pedigree; Peptide Fragments; Serine; Trypsin | 1975 |
The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships.
Topics: Amino Acid Sequence; Amino Acids; Animals; Biological Evolution; Chymotrypsin; Chymotrypsinogen; Disulfides; Enzyme Precursors; Models, Biological; Pancreatic Elastase; Peptide Hydrolases; Phylogeny; Prothrombin; Serine; Species Specificity; Trypsin; Trypsinogen | 1975 |
Histone III. VI. Two forms of calf thymus histone III.
Topics: Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Cattle; Chymotrypsin; Cysteine; Histones; Protein Conformation; Serine; Thymus Gland | 1975 |
Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes.
Topics: Amino Acid Sequence; Animals; Bacteria; Binding Sites; Biological Evolution; Chymotrypsin; Pancreas; Pancreatic Elastase; Peptide Hydrolases; Protein Conformation; Serine; Structure-Activity Relationship | 1975 |
A molecular orbital study on the effects of substituents on the proton transfer from ser-195 to his-57 in the hydrolysis of alpha-chymotrypsin.
Topics: Chymotrypsin; Histidine; Hydrogen Bonding; Protein Conformation; Protons; Serine; Thermodynamics | 1975 |
The importance of the conformation of the tetrahedral intermediate for the alpha-chymotrypsin-catalyzed hydrolysis of peptide substrates.
Topics: Binding Sites; Chymotrypsin; Dipeptides; Kinetics; Serine; Stereoisomerism; Structure-Activity Relationship | 1975 |
Catalysis by serine proteases and their zymogens. A study of acyl intermediates by circular dichroism.
Topics: Animals; Benzoates; Binding Sites; Cattle; Chymotrypsin; Chymotrypsinogen; Circular Dichroism; Guanidines; Peptide Hydrolases; Protein Binding; Protein Conformation; Serine; Structure-Activity Relationship; Trypsin; Trypsinogen | 1975 |
Solvent dielectric effects on protein dynamics.
Topics: Chymotrypsin; Computer Simulation; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Methionine; Models, Molecular; Motion; Protein Conformation; Serine; Solvents; Spin Labels | 1992 |
Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.
Topics: Amino Acid Sequence; Aminopeptidases; Antibodies; Antibody Specificity; Binding Sites; Chymotrypsin; Collagen; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Epitopes; Fibrin; Fibronectins; Heparin; Humans; Immunoblotting; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Serine; Serine Endopeptidases | 1990 |
Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase.
Topics: Acetyl-CoA Carboxylase; Amino Acid Sequence; Animals; Chickens; Chymotrypsin; Kinetics; Ligases; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Kinases; Rats; Sequence Homology, Nucleic Acid; Serine; Trypsin | 1990 |
Optimization of enzyme-mediated peptide bond formation.
Topics: Carboxypeptidases; Catalysis; Chymotrypsin; Dipeptides; Enzymes; Hydrogen-Ion Concentration; Hydrolysis; Osmolar Concentration; Papain; Phenylalanine; Serine; Temperature | 1990 |
Multisite phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic AMP-dependent protein kinase and glycogen synthase kinase-3.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Chymotrypsin; Glycogen; Glycogen Synthase; Glycogen Synthase Kinases; Isoelectric Focusing; Molecular Sequence Data; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Serine; Substrate Specificity; Trypsin | 1989 |
X-ray diffraction analysis of the inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone.
Topics: Binding Sites; Chymotrypsin; Models, Molecular; Protein Conformation; Pyrans; Pyrones; Serine; X-Ray Diffraction | 1986 |
Phosphorylation of human fibrinogen in vitro with protein kinase C: characterization of the phosphorylated sites.
Topics: Amino Acids; Animals; Binding Sites; Chromatography, Gel; Chromatography, High Pressure Liquid; Chymotrypsin; Cyanogen Bromide; Electrophoresis; Fibrinogen; Humans; Peptide Fragments; Phosphates; Phosphorylation; Protein Kinase C; Serine; Spleen; Swine; Trypsin | 1987 |
Time resolved quenching study of serine-195 labeled alpha-chymotrypsin.
Topics: Chymotrypsin; Kinetics; Organophosphorus Compounds; Serine; Spectrometry, Fluorescence | 1987 |
Phosphorylatable serine residues are located in a non-helical tailpiece of a catch muscle myosin.
Topics: Amino Acid Sequence; Animals; Chymotrypsin; Molecular Sequence Data; Mollusca; Muscles; Myosins; Phosphoserine; Serine | 1988 |
Identification of the penicillin-binding active site of penicillin-binding protein 2 of Escherichia coli.
Topics: Acyltransferases; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Carrier Proteins; Chromatography, High Pressure Liquid; Chymotrypsin; Escherichia coli; Hexosyltransferases; Molecular Sequence Data; Multienzyme Complexes; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin-Binding Proteins; Penicillins; Peptidyl Transferases; Serine; Trypsin | 1988 |
Filament formation and actin-activated ATPase activity are abolished by proteolytic removal of a small peptide from the tip of the tail of the heavy chain of Acanthamoeba myosin II.
Topics: Actins; Adenosine Triphosphatases; Amoeba; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Chymotrypsin; Macromolecular Substances; Microscopy, Electron; Molecular Weight; Myosins; Peptide Fragments; Phosphorylation; Serine; Ultracentrifugation | 1985 |
[The chemoselective fluorescence labeling of alpha-chymotrypsin].
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Fluorescent Dyes; Hydrogen-Ion Concentration; Methylation; Phosphines; Serine; Spectrometry, Fluorescence | 1985 |
Antigenic determinants in bovine alpha-chymotrypsin.
Topics: Amino Acids; Animals; Antigens; Cattle; Chymotrypsin; Cross Reactions; Epitopes; Histidine; Immune Sera; Ketones; Methionine; Precipitin Tests; Serine; Sulfonamides; Toluene; Urea | 1970 |
Studies of the heterogeneity of Streptomyces griseus protease. Isolation and characterization of an alkaline serine protease from commercial pronase-P derived from Streptomyces griseus K1.
Topics: Amino Acids; Calcium; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Freeze Drying; Hydrogen-Ion Concentration; Isoflurophate; Molecular Weight; Pancreatic Elastase; Peptide Hydrolases; Phosphorus Radioisotopes; Pronase; Protease Inhibitors; Serine; Streptomyces griseus; Temperature; Time Factors; Urea | 1973 |
Isolation of carbonic anhydrase from dog erythrocytes and determination of its N-terminal amino-acid sequence.
Topics: Amino Acid Sequence; Amino Acids; Animals; Benzoates; Carbonic Anhydrases; Carboxypeptidases; Cattle; Chymotrypsin; Disulfides; Dogs; Electrophoresis, Disc; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Erythrocytes; Histidine; Horses; Humans; Nitro Compounds; Phenylalanine; Serine; Species Specificity; Tryptophan; Ultracentrifugation | 1974 |
Evidence of homology between the beta-chain of human haptoglobin and the chymotrypsin family of serine proteases.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cattle; Chymotrypsin; Crossing Over, Genetic; Endopeptidases; Haptoglobins; Humans; Myxococcales; Pancreatic Elastase; Serine; Sharks; Swine; Trypsin | 1974 |
Studies on the active center of human plasmin. The serine and histidine residues.
Topics: Amino Acids; Autoanalysis; Autoradiography; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chymotrypsin; Electrophoresis; Fibrinolysin; Fibrinolytic Agents; Histidine; Humans; Isoflurophate; Ketones; Kinetics; Methods; Methylation; Oxidation-Reduction; Peptides; Phosphorus Isotopes; Plasminogen; Protein Hydrolysates; Serine; Trypsin | 1969 |
Bovine factor X 1a (activated Stuart factor). Evidence of homology with mammalian serine proteases.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Biological Evolution; Cattle; Chromatography, Gel; Chymotrypsin; Cyanogen Bromide; Endopeptidases; Enzyme Activation; Factor X; Fibrinolysin; Humans; Isoflurophate; Macromolecular Substances; Pancreas; Peptides; Phosphoric Acids; Phosphorus Isotopes; Serine; Species Specificity; Thrombin; Trypsin | 1972 |
Mechanism of action of alpha-1-antitrypsin.
Topics: alpha 1-Antitrypsin; Amino Acids; Anilides; Arginine; Aspartic Acid; Benzoates; Binding Sites; Binding, Competitive; Cholinesterase Inhibitors; Chymotrypsin; Fibrinolysin; Glyoxal; Histidine; Isoflurophate; Leucine; Lysine; Nitro Compounds; Pancreatic Elastase; Peptide Hydrolases; Protease Inhibitors; Serine; Structure-Activity Relationship; Subtilisins; Thrombin; Trypsin Inhibitors | 1973 |
Organophosphate spin-label studies of inhibited esterases, alpha-chymotrypsin and cholinesterase.
Topics: Binding Sites; Cholinesterase Inhibitors; Cholinesterases; Chymotrypsin; Electron Spin Resonance Spectroscopy; Isoflurophate; Phosphates; Serine; Thrombin; Trypsin | 1969 |
A new spin label specific for the active site of serine enzymes.
Topics: Acetylcholinesterase; Animals; Binding Sites; Brain Chemistry; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Fluorine; Free Radicals; Humans; Nerve Endings; Organophosphonates; Piperidines; Rats; Serine | 1969 |
[Primary structure of bovine s1 casein. Complete sequence].
Topics: Amino Acid Sequence; Amino Acids; Animals; Caseins; Cattle; Chymotrypsin; Hydrolysis; Molecular Weight; Papain; Phosphopeptides; Phosphoric Monoester Hydrolases; Serine; Thermolysin; Trypsin | 1971 |
Electron paramagnetic resonance probing of macromolecules: a comparison of structure-function relationships in chymotrypsinogen, -chymotrypsin and anhydrochymotrypsin.
Topics: Acetamides; Acylation; Chymotrypsin; Chymotrypsinogen; Electron Spin Resonance Spectroscopy; Enzyme Activation; Histidine; Hydrogen-Ion Concentration; Imidazoles; Indoles; Kinetics; Macromolecular Substances; Methionine; Protein Conformation; Rotation; Serine; Spectrum Analysis; Structure-Activity Relationship; Tosyl Compounds | 1972 |
A comparative study of spin-labeled serine enzymes: acetylcholinesterase, trypsin, -chymotrypsin, elastase, and subtilisin.
Topics: Acetylcholinesterase; Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Endopeptidases; Fluorine; Hydrogen-Ion Concentration; Indicators and Reagents; Organophosphorus Compounds; Pancreatic Elastase; Piperidines; Protein Binding; Serine; Subtilisins; Trypsin | 1972 |
Alkyl isocyanates as active-site-specific reagents for serine proteases. Reaction properties.
Topics: Acetone; Binding Sites; Carbon Isotopes; Chymotrypsin; Chymotrypsinogen; Cyanates; Drug Stability; Endopeptidases; Histidine; Hydrogen-Ion Concentration; Indoles; Kinetics; Microbial Collagenase; Models, Chemical; Pancreatic Elastase; Papain; Pepsin A; Protease Inhibitors; Serine; Structure-Activity Relationship; Trypsin; X-Ray Diffraction | 1973 |
ESR probing of macromolecules: spin-labeling of the active sites of the proteolytic serine enzymes.
Topics: Animals; Binding Sites; Blood; Cattle; Cholinesterases; Chymotrypsin; Electron Spin Resonance Spectroscopy; Erythrocytes; Esterases; Fluorides; Horses; Hydrogen-Ion Concentration; Kinetics; Organophosphonates; Pancreatic Elastase; Peptide Hydrolases; Protein Binding; Protein Conformation; Serine; Subtilisins; Thrombin; Trypsin Inhibitors | 1972 |
ESR probing of macromolecules: spin label study of the conformational integrity and transitions in modified alpha-chymotrypsin.
Topics: Alkylation; Binding Sites; Chymotrypsin; Electron Spin Resonance Spectroscopy; Fluorides; Hydrogen-Ion Concentration; Kinetics; Methionine; Organophosphonates; Oxidation-Reduction; Protein Conformation; Serine; Spectrophotometry, Ultraviolet | 1972 |
Identification of missense mutants by amino acid replacements in iso-1-cytochrome c from yeast.
Topics: Amino Acid Sequence; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Chymotrypsin; Cytochrome c Group; Electrophoresis; Genes; Heme; Hydrolysis; Isoleucine; Mutation; Peptides; Proline; RNA, Messenger; Saccharomyces cerevisiae; Serine; Threonine; Ultraviolet Rays | 1974 |
The primary structure of apolopoprotein-serine.
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Animals; Apoproteins; Carboxypeptidases; Chromatography, Gas; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Chymotrypsin; Cyanogen Bromide; Electrophoresis, Polyacrylamide Gel; Humans; Hyperlipidemias; Immunodiffusion; Lipoproteins, VLDL; Peptide Fragments; Rabbits; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Trypsin; Ultracentrifugation | 1974 |
I. Serine proteinases. The structure of alpha-chymotrypsin.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Models, Structural; Peptide Hydrolases; Protein Binding; Protein Conformation; Serine; Structure-Activity Relationship | 1970 |
Homologies in serine proteinases.
Topics: Amino Acid Sequence; Animals; Aspergillus; Bacillus subtilis; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Models, Structural; Pancreas; Pancreatic Elastase; Peptide Hydrolases; Protein Conformation; Proteus; Serine; Swine; Thrombin; Trypsin | 1970 |
TMV coat protein synthesis in vivo: analysis of the N-terminal acetylation.
Topics: Acetylation; Amino Acids; Carbon Radioisotopes; Chromatography, Paper; Chymotrypsin; Dipeptides; Nicotiana; Peptide Biosynthesis; Peptide Chain Termination, Translational; Peptide Fragments; Peptides; Plants, Toxic; RNA, Transfer; RNA, Viral; Serine; Tobacco Mosaic Virus; Tritium; Trypsin; Tyrosine; Viral Proteins | 1974 |
The existence of multiple conformational forms in anhydrochymotrypsin.
Topics: Acetophenones; Alanine; Alkylation; Binding Sites; Chymotrypsin; Circular Dichroism; Dialysis; Drug Stability; Freeze Drying; Kinetics; Methionine; Nitro Compounds; Plants; Protein Binding; Protein Conformation; Serine; Spectrophotometry, Ultraviolet; Time Factors; Trypsin Inhibitors | 1974 |
On the stereochemistry of catalysis by serine proteases.
Topics: Binding Sites; Catalysis; Chymotrypsin; Energy Transfer; Models, Structural; Protein Conformation; Serine; Stereoisomerism; Structure-Activity Relationship; Subtilisins; X-Ray Diffraction | 1974 |
Partial purification and characterization of a chymotrypsin-like enzyme from human neutrophil leucocytes.
Topics: Binding Sites; Chromatography, Gel; Chymotrypsin; Dithioerythritol; Electrophoresis, Polyacrylamide Gel; Histidine; Humans; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Molecular Weight; Neutrophils; Organ Specificity; Oxidation-Reduction; Pancreas; Phenylalanine; Phosphorus Radioisotopes; Protein Binding; Serine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tosyl Compounds; Ultracentrifugation | 1974 |
Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates.
Topics: Aspergillus; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Crystallization; Esterases; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Serine; Species Specificity; Streptomyces; Structure-Activity Relationship; Subtilisins; Time Factors | 1974 |
Amino acid sequences in the -chains of adult bovine hemoglobins C-Rhodesia and D-Zambia.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Chromatography, Ion Exchange; Chymotrypsin; Cyanogen Bromide; Electrophoresis, Starch Gel; Globins; Glutamine; Glycine; Hemoglobins, Abnormal; Lysine; Pepsin A; Peptides; Serine; Species Specificity; Thermolysin; Thiocyanates; Threonine; Trypsin; Ultracentrifugation; Zambia; Zimbabwe | 1972 |
Kinetics of the reaction of nitrous acid with model compounds and proteins, and the conformational state of N-terminal groups in the chymotrypsin family.
Topics: Amines; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Esters; Hydrogen-Ion Concentration; Indoleacetic Acids; Isoleucine; Kinetics; Nitrites; Nitroso Compounds; Osmolar Concentration; Pancreatic Elastase; Pepsin A; Peptides; Protein Conformation; Proteins; Serine; Spectrophotometry, Ultraviolet; Swine; Trypsin; Tryptophan; Tyrosine | 1972 |
The purification by affinity chromatography of a proteinase inhibitor binding species of anhydro-chymotrypsin.
Topics: Animals; Benzyl Compounds; Cattle; Chemical Phenomena; Chemistry; Chromatography, Affinity; Chymotrypsin; Fluorine; Immune Sera; Immunodiffusion; Plants; Polysaccharides; Protease Inhibitors; Protein Binding; Rabbits; Serine; Sulfonic Acids; Thermodynamics | 1972 |
The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). I. Purification of four serine endopeptidases.
Topics: Amines; Amino Acid Sequence; Amino Acids; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Electrophoresis, Disc; Endopeptidases; Esterases; Hydrogen-Ion Concentration; Hydrolysis; Isoflurophate; Molecular Weight; Peptide Hydrolases; Peptides; Phosphorus Isotopes; Pronase; Protease Inhibitors; Serine; Streptomyces; Streptomyces griseus; Structure-Activity Relationship; Trypsin | 1972 |
The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). II. The activity of a serine enzyme in 6 M guanidinium chloride.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chlorides; Chymotrypsin; Circular Dichroism; Drug Stability; Edetic Acid; Endopeptidases; Guanidines; Hydrolysis; Kinetics; Ovalbumin; Peptide Hydrolases; Peptides; Pronase; Protein Denaturation; Serine; Spectrophotometry; Streptomyces; Streptomyces griseus | 1972 |
Structure of crystalline methyl-chymotrypsin.
Topics: Acetates; Ammonium Sulfate; Binding Sites; Carbon Isotopes; Chromatography, Ion Exchange; Chymotrypsin; Crystallization; Histidine; Indoles; Mathematics; Methylation; Models, Structural; Nitrobenzenes; Nitrophenols; Protein Binding; Protein Conformation; Serine; Sulfonic Acids; Tosyl Compounds; Tryptophan; Ultrafiltration; X-Ray Diffraction | 1972 |
Calf thymus lysine- and serine-rich histone. II. Chymotryptic and thermolysin peptides.
Topics: Amino Acid Sequence; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography; Chymotrypsin; Histones; Hydrolysis; Lysine; Peptides; Serine; Thermolysin; Thymus Gland | 1972 |
A competitive labelling method for determining the ionization constants and reactivity of individual histidine residues in proteins. The histidines of -chymotrypsin.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Fluorides; Histidine; Hydrogen-Ion Concentration; Imidazoles; Ions; Isotope Labeling; Nitrobenzenes; Peptides; Protein Conformation; Serine; Tritium | 1972 |
Symmetry and asymmetry in the mechanisms of hydrolysis by serine proteases and their thiol analogues.
Topics: Binding Sites; Chymotrypsin; Cinnamates; Dicyclohexylcarbodiimide; Endopeptidases; Esters; Hydrogen-Ion Concentration; Kinetics; Mercuribenzoates; Nitrophenols; Protein Binding; Serine; Structure-Activity Relationship; Subtilisins; Sulfhydryl Compounds | 1972 |
Alkyl isocyanates as active-site-specific reagents for serine proteases. Identification of the active-site serine as the site of reaction.
Topics: Amino Acids; Binding Sites; Carbamates; Carbon Isotopes; Chromatography, Ion Exchange; Chymotrypsin; Cyanates; Endopeptidases; Formates; Hydrolysis; Oxidation-Reduction; Pancreatic Elastase; Peptides; Serine; Subtilisins; Trypsin | 1973 |
Inactivation of alpha-chymotrypsin by a bifunctional reagent, 3,4-dihydro-3,4-dibromo-6-bromomethylcoumarin.
Topics: Acetylation; Acridines; Alkylation; Amines; Binding Sites; Bromine; Chemical Phenomena; Chemistry; Chymotrypsin; Coumarins; Esters; Histidine; Hydrogen-Ion Concentration; Protein Binding; Serine; Structure-Activity Relationship | 1973 |
The preparation and characterization of an active derivative of bovine pancreatic deoxyribonuclease A formed by selective cleavage with alpha-chymotrypsin.
Topics: Acetates; Alkylation; Animals; Bromine; Calcium; Carboxypeptidases; Catalysis; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Deoxyribonucleases; Disulfides; Drug Stability; Electrophoresis, Disc; Enzyme Activation; Mercaptoethanol; Molecular Weight; Oxidation-Reduction; Pancreas; Serine; Sodium Dodecyl Sulfate; Tryptophan; Yeasts | 1973 |
Hybrid formation between collagen and synthetic polypeptides.
Topics: Alanine; Amino Acids; Animals; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Collagen; Glycine; Hybridization, Genetic; Molecular Conformation; Molecular Weight; Optical Rotation; Peptides; Proline; Protein Binding; Protein Conformation; Protein Denaturation; Rabbits; Serine; Skin; Temperature; Tropomyosin | 1973 |
Variability in the tertiary structure of alpha-chymotrypsin at 2.8-A resolution.
Topics: Amino Acid Sequence; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Electrons; Gold; Hydrogen-Ion Concentration; Macromolecular Substances; Mercury; Models, Structural; Platinum; Protein Conformation; Selenium; Serine; Sulfates; Tyrosine; Uranium; X-Ray Diffraction | 1973 |
Changes in the tertiary structure of alpha-chymotrypsin with change in pH: p4 4.2-6.7.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Chymotrypsin; Histidine; Hydrogen-Ion Concentration; Macromolecular Substances; Methionine; Models, Structural; Phenylalanine; Protein Binding; Protein Conformation; Serine; Tyrosine; Uranium; X-Ray Diffraction | 1973 |
A molecular orbital study on the enzymic reaction mechanism of alpha-chymotrypsin.
Topics: Acetamides; Acetates; Activation Analysis; Acylation; Aspartic Acid; Chymotrypsin; Histidine; Hydrolysis; Molecular Biology; Protein Binding; Quantum Theory; Serine; X-Ray Diffraction | 1973 |
The mechanism of the alpha-chymotrypsin and trypsin-catalyzed hydrolysis of amides. Evidence for the participation of the active serine in the amidase activity of trypsin.
Topics: Amides; Amidohydrolases; Anilides; Chymotrypsin; Esterases; Esters; Hydrolysis; Kinetics; Serine; Structure-Activity Relationship; Trypsin | 1973 |
Theoretical conformational analysis of methylamides of N-acetyl-L-serine and N-acetyl-L-asparagine.
Topics: Amides; Asparagine; Carboxypeptidases; Chemical Phenomena; Chemistry; Chymotrypsin; Lactalbumin; Models, Structural; Molecular Conformation; Muramidase; Myoglobin; Optical Rotation; Peptides; Ribonucleases; Serine; Spectrophotometry, Infrared | 1973 |
Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit.
Topics: Amides; Amino Acid Sequence; Amino Acids; Animals; Cattle; Chorionic Gonadotropin; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Female; Glycopeptides; Humans; Luteinizing Hormone; Molecular Weight; Oligosaccharides; Oxidation-Reduction; Pregnancy; Serine; Sheep; Species Specificity; Swine; Thermolysin; Trypsin | 1973 |
Consequences of the modification of tryptophan-215 on the function of bovine alpha-chymotrypsin.
Topics: Animals; Benzene Derivatives; Benzyl Compounds; Binding Sites; Catalysis; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Histidine; Humans; Indicators and Reagents; Organophosphorus Compounds; Phenols; Phosphates; Propane; Protein Conformation; Serine; Trypsin Inhibitors; Tryptophan | 1973 |
Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New).
Topics: Alkylation; Amino Acid Sequence; Amino Acids; Chromatography, Gel; Chymotrypsin; Dansyl Compounds; Electrophoresis; Formates; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fragments; Immunoglobulin G; Lysine; Multiple Myeloma; Myeloma Proteins; Oxidation-Reduction; Peptide Fragments; Serine; Thiocyanates; Tosyl Compounds; Trypsin; X-Ray Diffraction | 1974 |
The interaction of some microbial and mammalian proteinases with human blood trypsin inhibitors.
Topics: Animals; Aspergillus; Chromatography, Gel; Chymotrypsin; Humans; Kinetics; Pancreatic Elastase; Pronase; Protease Inhibitors; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Streptomyces; Subtilisins; Thermolysin; Trypsin Inhibitors | 1974 |
Amino acid sequence of the peptide released from bovine factor XIII following activation by thrombin.
Topics: Acetamides; Amino Acid Sequence; Amino Acids; Animals; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Chymotrypsin; Dansyl Compounds; Factor XIII; Humans; Peptide Fragments; Serine; Thermolysin; Thrombin; Trypsin | 1974 |
Conformational changes and association of chemically modified chymotrypsins.
Topics: Benzenesulfonates; Binding Sites; Chromatography, Gel; Chymotrypsin; Histidine; Hydrogen-Ion Concentration; Methionine; Molecular Weight; Nitro Compounds; Optical Rotatory Dispersion; Phenols; Protein Binding; Protein Conformation; Serine; Spectrophotometry, Ultraviolet; Tosyl Compounds; Ultracentrifugation | 1974 |
A family of protein-cutting proteins.
Topics: Binding Sites; Chymotrypsin; Endopeptidases; Enzyme Activation; Humans; Hydrolysis; Models, Structural; Pancreatic Elastase; Serine; Trypsin | 1974 |
High resolution nuclear magnetic resonance studies of the active site of chymotrypsin. I. The hydrogen bonded protons of the "charge relay" system.
Topics: Aspartic Acid; Binding Sites; Chymotrypsin; Chymotrypsinogen; Deuterium; Histidine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Serine | 1974 |
Theoretical calculations on an acetic acid, 5-methylimidazole, methanol hydrogen bond network: a model charge relay system.
Topics: Acetates; Aspartic Acid; Carboxylic Acids; Chymotrypsin; Hydrogen; Hydrogen-Ion Concentration; Imidazoles; Ions; Methanol; Models, Chemical; Serine | 1974 |
Mechanism of action of naturally occurring proteinase inhibitors. Studies with anhydrotrypsin and anhydrochymotrypsin purified by affinity chromatography.
Topics: Alanine; Binding Sites; Binding, Competitive; Borohydrides; Carbon Radioisotopes; Chromatography, Affinity; Chymotrypsin; Circular Dichroism; Egg Proteins; Glycine max; Hydrogen-Ion Concentration; Hydrolysis; Mucoproteins; Oxidation-Reduction; Pancreas; Plants; Protein Denaturation; Serine; Spectrophotometry, Ultraviolet; Tritium; Trypsin; Trypsin Inhibitors | 1974 |
An application of diagonal electrophoresis to the selective purification of serine phosphate peptides. Serine phosphate peptides from ovalbumin.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Chymotrypsin; Electrophoresis; Isoleucine; Leucine; Lysine; Ovalbumin; Pepsin A; Peptides; Proline; Serine; Trypsin | 1968 |
Unavailability of cystine from trypsin inhibitors as a factor contributing to the poor nutritive value of navy beans.
Topics: Amino Acids; Animals; Aspartic Acid; Chickens; Chymotrypsin; Cystine; Diet; Feces; Glutamates; Hot Temperature; Intestinal Mucosa; Nutritional Physiological Phenomena; Organ Size; Pancreas; Pepsin A; Plant Proteins; Plants, Edible; Proline; Protein Binding; Serine; Threonine; Trypsin; Trypsin Inhibitors | 1969 |
On the chemical structure of antigens and antibodies bound to fluorescent dyes. I. Structure of the antihuman gamma-globulin of the goat bound to the fluorochrome lissamine rhodamine B.
Topics: Amino Acids; Animals; Antibodies, Anti-Idiotypic; Antigens; Arginine; Aspartic Acid; Chromatography, Paper; Chymotrypsin; Electrophoresis; Fluorescent Dyes; Fluorometry; Goats; Histidine; Lysine; Oxidation-Reduction; Pepsin A; Protein Binding; Serine; Sulfides; Trypsin; Tryptophan; Tyrosine | 1966 |
Horse liver alcohol dehydrogenase. The primary structure of the protein chain of the ethanol-active isoenzyme.
Topics: Alcohol Oxidoreductases; Alkylation; Amino Acid Sequence; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Chymotrypsin; Cyanides; Cysteine; Ethanol; Histidine; Horses; Iodoacetates; Isoenzymes; Liver; Malates; Methionine; Mutation; Pepsin A; Peptides; Serine; Trypsin | 1970 |
Horse liver alcohol dehydrogenase. The primary structure of an N-terminal part of the protein chain of the ethanol-active isoenzyme.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Binding Sites; Carbon Isotopes; Chromatography, Gel; Chymotrypsin; Crustacea; Cyanides; Cysteine; Ethanol; Glyceraldehyde-3-Phosphate Dehydrogenases; Horses; Iodoacetates; Isoenzymes; Liver; Maleates; Pepsin A; Serine; Species Specificity; Swine; Trypsin; Tryptophan; Tyrosine | 1970 |
Formaldehyde-induced cross-linkages in the subunit of the Escherichia coli tryptophan synthetase.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Paper; Chymotrypsin; Electrophoresis; Electrophoresis, Disc; Escherichia coli; Formaldehyde; Glutamine; Glycerophosphates; Hydro-Lyases; Indoles; Kinetics; Lysine; Molecular Weight; Paper; Pepsin A; Peptides; Serine; Trypsin; Tryptophan | 1971 |
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.
Topics: Acetates; Amino Acid Sequence; Amino Acids; Anhydrides; Animals; Arginine; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Follicle Stimulating Hormone; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Hypothalamus; Leucine; Luteinizing Hormone; Mass Spectrometry; Methods; Naphthalenes; Peptides; Pituitary Hormone-Releasing Hormones; Proline; Serine; Sulfonic Acids; Swine; Thiocyanates; Tritium; Tryptophan; Tyrosine | 1971 |
Inhibition of "serine" esterases by phenylarsonic acids. alpha-chymotrypsin and the subtilisins.
Topics: Arsenic; Bacillus subtilis; Benzene Derivatives; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Coloring Agents; Crystallization; Esterases; Hydrogen-Ion Concentration; Kinetics; Protease Inhibitors; Serine; Spectrophotometry | 1968 |
Comparison of the specificities of various serine proteinases from microorganisms.
Topics: Amino Acids; Aspergillus; Bacillus subtilis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Hydrogen-Ion Concentration; Insulin; Kinetics; Leucine; Peptide Hydrolases; Peptides; Phenylalanine; Protease Inhibitors; Serine; Streptomyces; Tyrosine | 1969 |
Human pancreatic enzymes. Isolation and properties of a major form of chymotrypsin.
Topics: Acetone; Amino Acids; Animals; Asparagine; Butanones; Calcium Chloride; Cattle; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cysteine; Electrophoresis, Disc; Humans; Hydrogen-Ion Concentration; Immunodiffusion; Isoflurophate; Isoleucine; Molecular Weight; Pancreas; Quaternary Ammonium Compounds; Rabbits; Serine; Species Specificity; Spectrophotometry; Sulfates; Trypsin; Ultracentrifugation; Ultraviolet Rays | 1971 |
Acylation of chymotrypsin by active esters of nonspecific substrates. Evidence for a transient acylimidazole intermediate.
Topics: Acylation; Benzoates; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Deuterium; Dinitrophenols; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Mathematics; Models, Chemical; Nitrophenols; Protein Binding; Serine; Structure-Activity Relationship | 1972 |
The developmental biochemistry of cottonseed embryogenesis and germination. II. Catalytic properties of the cotton carboxypeptidase.
Topics: Binding Sites; Carbon Isotopes; Carboxypeptidases; Catalysis; Chymotrypsin; Electrophoresis, Disc; Electrophoresis, Paper; Esters; Gossypium; Hydrolysis; Kinetics; Macromolecular Substances; Peptides; Phosphorus Isotopes; Plants; Protein Binding; Protein Denaturation; Proteins; Serine; Sodium Dodecyl Sulfate; Structure-Activity Relationship; Sulfhydryl Reagents | 1972 |
Identification of the chymotrypsin-reactive site of the Bowman-Birk soybean inhibitor.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Chromatography, Gel; Chymotrypsin; Formates; Glycine max; Leucine; Oxidation-Reduction; Peptides; Serine; Trypsin Inhibitors | 1972 |
A chemical and crystallographic study of carbamyl-chymotrypsin A.
Topics: Acetates; Amino Acids; Animals; Binding Sites; Carbamates; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cyanates; Cyanides; Cyanogen Bromide; Cysteine; Glycine; Models, Structural; Nitrophenols; Pancreas; Phenylalanine; Protein Conformation; Serine; Succinates; Water; X-Ray Diffraction | 1972 |
Antitrypsin site of lima bean protease inhibitor.
Topics: Alkylation; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Carboxypeptidases; Chromatography, Ion Exchange; Chymotrypsin; Electrophoresis, Paper; Iodoacetates; Kinetics; Lysine; Mercaptoethanol; Oxidation-Reduction; Peptides; Plant Proteins; Serine; Swine; Trypsin; Trypsin Inhibitors | 1972 |
Diversity of proteases in the keratinolytic larvae of the webbing clothes moth, Tineola bisselliella.
Topics: Amino Acids; Aminopeptidases; Ammonium Sulfate; Animals; Chymotrypsin; Digestion; Electrophoresis, Disc; Endopeptidases; Hydrolysis; Insecta; Keratins; Larva; Peptide Hydrolases; Protease Inhibitors; Serine; Structure-Activity Relationship; Trypsin; Zinc | 1972 |
Catalytic activity of trypsin with an acylated "active" serine.
Topics: Alkylation; Amides; Amidohydrolases; Animals; Cattle; Chromatography, Gel; Chymotrypsin; Culture Techniques; Esterases; Kinetics; Peptides; Serine; Spectrophotometry; Trypsin | 1971 |
Partial identification of a chymotrypsin formed by incubation of bovine chymotrypsinogen A with papain.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Enzyme Activation; Enzyme Precursors; Glycine; Leucine; Papain; Serine; Spectrophotometry; Time Factors; Ultraviolet Rays | 1971 |
Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.
Topics: Acylation; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chlorine; Chymotrypsin; Chymotrypsinogen; Crystallography; Electrons; Histidine; Isoleucine; Ketones; Mathematics; Models, Structural; Peptides; Phenylalanine; Serine; X-Ray Diffraction | 1971 |
Catalytic activity of -chymotrypsin in which histidine-57 has been methylated.
Topics: Acridines; Acylation; Amides; Catalysis; Chromatography; Chymotrypsin; Esters; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Methylation; Nitrophenols; Serine | 1971 |
Imidazole-catalyzed displacement of an amine from an amide by a neighboring hydroxyl group. A model for the acylation of chymotrypsin.
Topics: Acylation; Amides; Amines; Catalysis; Chymotrypsin; Hydroxylation; Imidazoles; Models, Chemical; Peptide Hydrolases; Serine | 1971 |
Group separation: a new method facilitating isolation of peptides from digests of high molecular weight proteins.
Topics: Anhydrides; Arginine; Carboxypeptidases; Chromatography, Ion Exchange; Chymotrypsin; Cysteine; Endopeptidases; Histidine; Imides; Lysine; Maleates; Methionine; Methods; Peptides; Phosphoproteins; Proteins; Serine; Trypsin | 1971 |
Probing the topography of the active site of alpha-chymotrypsin.
Topics: Binding Sites; Catalysis; Chymotrypsin; Models, Biological; Serine | 1967 |
Non-pancreatic proteases of the chymotrypsin family. I. A chymotrypsin-like protease from rat mast cells.
Topics: Acrylates; Animals; Arginine; Benzoates; Binding Sites; Cell Count; Cell Fractionation; Cell Nucleus; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Dextrans; Endopeptidases; Enzyme Precursors; Esters; Gels; Histidine; Hydrogen-Ion Concentration; Isoflurophate; Ketones; Kinetics; Male; Mast Cells; Methods; Microscopy, Electron; Molecular Weight; Osmolar Concentration; Peritoneal Cavity; Phosphorus Isotopes; Potassium Chloride; Rats; Serine; Sulfonic Acids; Toluene; Tritium; Tyrosine | 1971 |
Structure of crystalline alpha-chymotrypsin. 3. Crystallographic studies of substrates and inhibitors bound to the active site of alpha-chymotrypsin.
Topics: Arginine; Aspartic Acid; Binding Sites; Chymotrypsin; Histidine; Indoles; Lysine; Molecular Biology; Peptides; Protein Binding; Serine; Toluene; Trypsin; Tryptophan; X-Ray Diffraction | 1969 |
Properties of colostrokinin from bovine colostrum.
Topics: Acetone; Amino Acids; Animals; Blood; Bradykinin; Capillary Permeability; Cattle; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Chymotrypsin; Colostrum; Dialysis; Dogs; Electrophoresis; Ethanol; Female; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Ileum; Immunoglobulins; Kinins; Lactoglobulins; Molecular Weight; Muscle Contraction; Paper; Phenylalanine; Rats; Serine; Solubility; Spectrophotometry; Trypsin; Uterus; Vasodilator Agents | 1969 |
Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases.
Topics: Amino Acid Sequence; Animals; Carbon Isotopes; Chromatography, Gel; Chromatography, Paper; Chymotrypsin; Electrophoresis; Methods; Pancreas; Pancreatic Elastase; Serine; Swine; Trypsin | 1970 |
Sedimentation of chemically modified chymotrypsin.
Topics: Acetates; Amino Acid Sequence; Amino Acids; Chemical Phenomena; Chemistry; Chymotrypsin; Cinnamates; Guanidines; Histidine; Hydrogen-Ion Concentration; Lysine; Methionine; Serine; Sulfonic Acids; Toluene; Ultracentrifugation | 1970 |
[Cyclodextrin-imidazole compounds].
Topics: Binding Sites; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Histidine; Imidazoles; Models, Chemical; Models, Structural; Polysaccharides; Serine | 1970 |
Interactions of the endopeptidase subunit of bovine procarboxypeptidase A-S6.
Topics: Amino Acids; Animals; Binding Sites; Butanones; Carbon Isotopes; Carboxypeptidases; Cattle; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cinnamates; Electrophoresis, Disc; Endopeptidases; Enzyme Activation; Enzyme Precursors; Formates; Histidine; Imidazoles; Isoflurophate; Molecular Weight; Pancreas; Peptides; Phosphorus Isotopes; Serine; Trypsin | 1970 |
Irreversible enzyme inibitiors. CLXXII. Proteolytic enzymes. XVI. Covalent bonding of the sulfonyl fluoride group to serine outside the active site of alpha-chymotrypsin by exo-type active-site directed irreversible inhibitors.
Topics: Binding Sites; Chymotrypsin; Fluorides; Methods; Serine | 1970 |
Gibbon fibrinopeptides: identification of a glycine-serine allelism at position B-3.
Topics: Alleles; Amino Acid Sequence; Amino Acids; Animals; Chymotrypsin; Fibrin; Glycine; Heterozygote; Hominidae; Homozygote; Molecular Biology; Peptides; Plasmapheresis; Serine | 1970 |
X-ray diffraction studies of enzymes.
Topics: Albumins; Binding Sites; Carboxypeptidases; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Enzymes; Glycine; Methods; Models, Structural; Muramidase; Pancreas; Papain; Peptide Hydrolases; Protein Binding; Ribonucleases; Serine; Thermodynamics; Tyrosine; X-Ray Diffraction | 1970 |
The amino acid sequence of the beta-chains of rabbit hemoglobin.
Topics: Amino Acid Sequence; Animals; Asparagine; Chromatography, Ion Exchange; Chymotrypsin; Hemoglobins; Histidine; Leucyl Aminopeptidase; Peptides; Rabbits; Serine; Trypsin | 1970 |
Amino-terminal-blocked tripeptide analogues of the active site of -chymotrypsin.
Topics: Acrylates; Amino Acid Sequence; Amino Acids; Aspartic Acid; Barium; Benzyl Compounds; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Formates; Furans; Glycine; Hydrogen; Hydrolysis; Hydroxides; Imidazoles; Methods; Oxidation-Reduction; Peptides; Serine | 1970 |
Phosphonate inhibition of theaccumulation and retention of K+ by rabbit neutrophils in relation to chemotaxis.
Topics: Animals; Chemotaxis; Cholinesterase Inhibitors; Chymotrypsin; Enzyme Activation; Esterases; Filtration; Neutrophils; Organophosphonates; Potassium; Rabbits; Serine | 1971 |
2-phenylethaneboronic acid, a possible transition-state analog for chymotrypsin.
Topics: Acylation; Amides; Binding Sites; Boronic Acids; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Cinnamates; Hippurates; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Serine; Sulfonic Acids | 1971 |
Acyl-transfer reactions of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases. Concerning the N protonation of amides and amide-imidate equilibria.
Topics: Acyltransferases; Alcohols; Amides; Chymotrypsin; Cysteine; Endopeptidases; Esters; Papain; Serine; Sulfur; Thermodynamics | 1971 |
S-carboxymethylcysteine from the photolysis of diazoacyl trypsin and chymotrypsin.
Topics: Azo Compounds; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Chymotrypsin; Cysteine; Electrophoresis; Formates; Hydrogen Peroxide; Malonates; Oxidation-Reduction; Photolysis; Serine; Sulfides; Trypsin | 1971 |
Selective inhibition of serine proteases by alkyldimethylbenzylammonium chloride.
Topics: Acridines; Amines; Arginine; Benzalkonium Compounds; Benzyl Compounds; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Chymotrypsin; Cinnamates; Enzyme Activation; Guanidines; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Imidazoles; Iodine; Kinetics; Models, Chemical; Models, Structural; Optical Rotatory Dispersion; Osmolar Concentration; Oxidation-Reduction; Palmitic Acids; Pancreatic Elastase; Protease Inhibitors; Protein Denaturation; Serine; Spectrophotometry; Sulfonic Acids; Temperature; Toluene; Trypsin Inhibitors | 1971 |
Comparative studies on the primary structure of soluble and mitochondrial glutamic oxaloacetic transaminase isozymes. II. Amino acid sequence of the amino terminal fragments.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Aminobutyrates; Animals; Aspartate Aminotransferases; Chemical Phenomena; Chemistry; Chromatography, Paper; Chymotrypsin; Cyanides; Endopeptidases; Glutamates; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Hydroxybutyrates; Isoenzymes; Mitochondria, Muscle; Myocardium; Peptides; Phenylalanine; Proline; Serine; Solubility; Swine; Thiocyanates; Tryptophan; Valine | 1971 |
Haemoglobin Rampa: Alpha 95 Pro--Ser.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, DEAE-Cellulose; Chymotrypsin; Hemoglobins, Abnormal; Humans; India; Peptides; Proline; Serine; Trypsin | 1971 |
Steric effects in imidazole-catalyzed hydrolysis of esters of N-acetylserinamide and of p-nitrophenol.
Topics: Acetates; Amides; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Imidazoles; Models, Chemical; Nitrophenols; Serine | 1968 |
Structural analysis of the glycine-rich, arginine-rich histone. I. Sequence of the carbosyl-terminal portion.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Bromine; Carboxypeptidases; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Electrophoresis; Glycine; Histones; Peptides; Phenylalanine; Serine; Thymus Gland; Trypsin; Tyrosine | 1968 |
Calf and pea histone IV. I. Amino acid compositions and the identical COOH-terminal 19-residue sequence.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Evolution; Bromine; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Plants; Proline; Serine; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Homologies between thrombin and other serine proteinases.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Serine; Thrombin | 1968 |
States of amino acid residues in proteins. XVI. Naphthoquinones with two sulfonic groups as a reagent for discrimation of amino groups in proteins.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chymotrypsin; Colorimetry; Freezing; Glycine; Histidine; Hydrogen-Ion Concentration; Imidazoles; Indicators and Reagents; Insulin; Lysine; Muramidase; Naphthoquinones; Proline; Proteins; Ribonucleases; Serine; Spectrophotometry; Sulfonic Acids; Tryptophan; Tyrosine | 1968 |
Primary structures of serine proteinases.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Pancreas; Peptide Hydrolases; Serine | 1968 |
Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Biochemical Phenomena; Biochemistry; Chymotrypsin; Crystallography; Enzyme Activation; Enzyme Precursors; Histidine; Isoleucine; Mercury; Methionine; Models, Structural; Platinum; Serine; Trypsin | 1968 |
Structure of subtilisin BPN' at 2.5 angström resolution.
Topics: Amino Acid Sequence; Bacteria; Chymotrypsin; Crystallization; Electrons; Endopeptidases; Histidine; Methionine; Models, Structural; Platinum; Serine; Trypsin; X-Ray Diffraction | 1969 |
Role of a buried acid group in the mechanism of action of chymotrypsin.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteria; Binding Sites; Chymotrypsin; Endopeptidases; Histidine; Serine | 1969 |
Kinetic properties of the alpha-lytic protease of Sorangium sp., a bacterial homologue of the pancreatopeptidases.
Topics: Acetates; Amino Acid Sequence; Arginine; Bacteria; Catalysis; Chymotrypsin; Deuterium; Electrophoresis; Esters; Histidine; Hydrogen-Ion Concentration; Kinetics; Nitrophenols; Pancreatic Elastase; Peptide Hydrolases; Protease Inhibitors; Protein Binding; Serine; Spectrophotometry; Trypsin; Tryptophan; Tyrosine | 1969 |
The mechanism of irreversible adrenergic blockade by N-carbethoxydihydroquinolines--model studies with typical serine hydrolases.
Topics: Acetylcholinesterase; Air; Binding Sites; Carbamates; Chemical Phenomena; Chemistry; Chymotrypsin; Esterases; Hydrolases; Oxidation-Reduction; Peroxides; Protease Inhibitors; Quinolines; Sensory Receptor Cells; Serine; Sympatholytics; Time Factors | 1969 |
Products from the photolysis of diazoacetyl chymotrypsin.
Topics: Azo Compounds; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Glycolates; Histidine; Light; Serine; Tyrosine | 1966 |
The formation of anhydrochymotrypsin by removing the elements of water from the serine at the active site.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Serine | 1966 |
Isolation of the B and C chains from S-sulfonated alpha-chymotrypsin.
Topics: Amino Acids; Autoanalysis; Chromatography; Chromatography, Gel; Chymotrypsin; Enzyme Precursors; Peptides; Phosphorus Isotopes; Serine; Solubility; Spectrophotometry; Sulfites; Trichloroacetic Acid; Urea | 1966 |
Histidine sequences in the active centres of some 'serine' proteinases.
Topics: Amino Acid Sequence; Animals; Carboxypeptidases; Cattle; Chymotrypsin; Electrophoresis; Enzyme Precursors; Histidine; Hydrogen-Ion Concentration; In Vitro Techniques; Ketones; Pancreatic Elastase; Peptides; Serine; Swine; Trypsin | 1966 |
Reaction of an extracellular proteolytic enzyme from a strain of Arthrobacter with diisopropylphosphofluoridate (DFP).
Topics: Amino Acid Sequence; Arthrobacter; Chymotrypsin; Fluorine; Isoflurophate; Peptide Hydrolases; Radioisotopes; Serine | 1966 |
Evidence for N to O transfer in the deacylation of an acyl-alpha-chymotrypsin.
Topics: Chemical Phenomena; Chemistry; Chymotrypsin; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Nitrogen; Oxygen; Serine; Spectrophotometry | 1967 |
Concerning the nature of the alpha- and beta-lytic proteases of Sorangium sp.
Topics: Amino Acid Sequence; Arthrobacter; Autoradiography; Bacteria; Bacteriolysis; Chemical Phenomena; Chemistry; Chymotrypsin; Dialysis; Endopeptidases; Enzymes; Filtration; Isoflurophate; Peptide Hydrolases; Phosphorus Isotopes; Serine; Trypsin | 1967 |
A new stepwise synthesis of an octapeptide corresponding to a sequence around the "reactive" serine of chymotrypsin.
Topics: Amino Acid Sequence; Chemistry, Organic; Chymotrypsin; Organic Chemistry Phenomena; Peptides; Serine | 1967 |
Amino acid sequence around the histidine residue of the alpha-lytic protease of Sorangium sp., a bacterial homolog of the pancreatic serine proteases.
Topics: Amino Acid Sequence; Bacteria; Chymotrypsin; Electrophoresis; Histidine; Peptide Hydrolases; Peptides; Serine | 1967 |
Dimerization and activity of chymotrypsin at pH4.
Topics: Buffers; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Hydrogen-Ion Concentration; Ions; Molecular Weight; Nitrophenols; Serine; Spectrophotometry; Ultracentrifugation | 1967 |
Interaction between serine (pro)enzymes, and Kazal and Kunitz inhibitors.
Topics: Aprotinin; Chymotrypsin; Enzyme Precursors; Hydrogen-Ion Concentration; Kallikreins; Kinetics; Models, Molecular; Serine; Spectrophotometry; Trypsin; Trypsin Inhibitor, Kazal Pancreatic; Trypsin Inhibitors; Trypsinogen | 1983 |
Novel inactivators of serine proteases based on 6-chloro-2-pyrone.
Topics: Biotransformation; Chymotrypsin; Kinetics; Protease Inhibitors; Serine; Structure-Activity Relationship | 1983 |
Specificity in the alkylation of serine at the active site of alpha-chymotrypsin by aromatic alpha-bromo amides.
Topics: Alkylation; Amines; Binding Sites; Chymotrypsin; Kinetics; Models, Molecular; Protein Binding; Protein Conformation; Serine; Structure-Activity Relationship | 1980 |
Inhibition of elastase and other serine proteases by heterocyclic acylating agents.
Topics: Animals; Binding Sites; Cathepsins; Chymotrypsin; Humans; Kinetics; Leukocytes; Pancreas; Pancreatic Elastase; Protease Inhibitors; Protein Binding; Saccharin; Serine; Structure-Activity Relationship; Swine; Thiazoles; Trypsin Inhibitors | 1980 |
Transition state affinity jump chromatography. A double selection method for isolating catalytically active enzymes and other molecules.
Topics: Alanine; Chromatography, Affinity; Chymotrypsin; Enzymes, Immobilized; Serine; Tritium | 1980 |
Application of photoactivatable fluorescent active-site directed probes to serine-containing enzymes.
Topics: Affinity Labels; Azides; Binding Sites; Chymotrypsin; Fluorescent Dyes; Kinetics; Photolysis; Protein Conformation; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Trypsin | 1981 |
Primary structure of a chymotryptic peptide containing the "active serine" of the thioesterase domain of fatty acid synthase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Chymotrypsin; Fatty Acid Synthases; Geese; Humans; Isoflurophate; Peptide Fragments; Serine; Species Specificity; Thiolester Hydrolases | 1981 |
Interactions between Asp, His, Ser residues within models of the active site of serine proteases. A theoretical empirical study.
Topics: Aspartic Acid; Binding Sites; Chymotrypsin; Dipeptides; Endopeptidases; Histidine; Models, Molecular; Protein Conformation; Serine; Serine Endopeptidases; Structure-Activity Relationship; Subtilisins | 1982 |
Synthesis, conformation and reactivity towards p-nitrophenyl acetate of polypeptides incorporating aspartic acid, serine and histidine.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Chymotrypsin; Circular Dichroism; Histidine; Nitrophenols; Peptides; Protein Conformation; Serine; Spectrophotometry, Infrared; Structure-Activity Relationship; Subtilisins | 1982 |
Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: consequence on DNA binding.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinase II; Cell Line; Chymotrypsin; DNA; DNA-Binding Proteins; Female; Humans; Molecular Sequence Data; Peptide Fragments; Phosphates; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Estrogen; Recombinant Proteins; Serine; Spodoptera; Substrate Specificity; Transfection; Trypsin; Tumor Cells, Cultured | 1995 |
A low-barrier hydrogen bond in the catalytic triad of serine proteases.
Topics: Aspartic Acid; Catalysis; Chymotrypsin; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Maleates; Malonates; Serine; Serine Endopeptidases; Temperature; Urocanic Acid | 1994 |
Probing the mechanism of CRP activation by site-directed mutagenesis: the role of serine 128 in the allosteric pathway of cAMP receptor protein activation.
Topics: Allosteric Regulation; Base Sequence; Chymotrypsin; Circular Dichroism; Cyclic AMP; Cyclic AMP Receptor Protein; Cyclic GMP; DNA; DNA-Binding Proteins; Fluorescence Polarization; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Serine | 1995 |
Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209.
Topics: Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Chymotrypsin; DNA Primers; Eukaryotic Initiation Factor-4E; Humans; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Phosphorylation; Serine | 1995 |
gamma-Glutamyltranspeptidase-catalysed acyl-transfer to the added acceptor does not proceed via the ping-pong mechanism.
Topics: Animals; Binding Sites; Catalysis; Cattle; Chymotrypsin; gamma-Glutamyltransferase; Glutamine; Hydrolysis; Kinetics; Models, Biological; Oligopeptides; Serine; Stereoisomerism | 1994 |
Identification and characterization of O-biotinylated hydroxy amino acid residues in peptides.
Topics: Amino Acid Sequence; Amyloid; Biotin; Chromatography, High Pressure Liquid; Chymotrypsin; Humans; Hydroxylamine; Hydroxylamines; Indicators and Reagents; Islet Amyloid Polypeptide; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Peptides; Serine; Spectrometry, Mass, Fast Atom Bombardment; Threonine | 1994 |
Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Catalysis; Chymotrypsin; Enzyme Precursors; Histidine; Hydrogen Bonding; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasminogen; Plasminogen Activator Inhibitor 1; Serine; Tissue Plasminogen Activator | 1993 |
11B NMR spectroscopy of peptide boronic acid inhibitor complexes of alpha-lytic protease. Direct evidence for tetrahedral boron in both boron-histidine and boron-serine adduct complexes.
Topics: Amino Acid Sequence; Boron; Boronic Acids; Chymotrypsin; Gram-Negative Bacteria; Histidine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Serine; Serine Endopeptidases | 1993 |
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Arginine; Binding Sites; Chymotrypsin; HeLa Cells; Humans; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Kinases; Ribonucleoprotein, U1 Small Nuclear; RNA Splicing; Serine | 1993 |
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.
Topics: Adult; alpha 1-Antitrypsin; Animals; Cattle; Chymotrypsin; Homozygote; Humans; Liver Diseases; Male; Microscopy, Electron; Models, Molecular; Mutation; Phenylalanine; Polymers; Serine | 1993 |
Substitution of serine for glycine-91 in the HXGH motif of CTP:phosphocholine cytidylyltransferase implicates this motif in CTP binding.
Topics: Animals; Base Sequence; Cell Line; Choline-Phosphate Cytidylyltransferase; Chymotrypsin; Glycine; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotidyltransferases; Protein Denaturation; Serine; Substrate Specificity; Urea | 1996 |
The tortuous story of Asp ... His ... Ser: structural analysis of alpha-chymotrypsin.
Topics: Amino Acid Sequence; Aspartic Acid; Chymotrypsin; Histidine; Protein Structure, Tertiary; Serine | 1997 |
Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A.
Topics: Binding Sites; Chymases; Chymotrypsin; Computer Simulation; Crystallography, X-Ray; Histidine; Humans; Models, Molecular; Phenylmethylsulfonyl Fluoride; Protein Conformation; Serine; Serine Endopeptidases; Substrate Specificity | 1997 |
Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
Topics: Binding Sites; Boronic Acids; Chymotrypsin; Crystallography, X-Ray; Histidine; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Conformation; Serine; Serine Proteinase Inhibitors; Stereoisomerism; Subtilisins | 1998 |
The inhibitory specificity of human proteinase inhibitor 8 is expanded through the use of multiple reactive site residues.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Cattle; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Multienzyme Complexes; Serine; Serpins; Sodium Dodecyl Sulfate; Substrate Specificity; Thrombin | 1998 |
Effect of exceptional valine replacement for highly conserved alanine-55 on the catalytic site structure of chymotrypsin-like serine protease.
Topics: Alanine; Amino Acid Sequence; Animals; Asparagine; Binding Sites; Cattle; Chymotrypsin; Histidine; Models, Molecular; Molecular Sequence Data; Protein C; Protein Conformation; Sequence Alignment; Serine; Threonine; Valine | 1998 |
Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor.
Topics: Amino Acid Sequence; Animals; Aphids; Binding Sites; Blotting, Western; Chymotrypsin; Cloning, Molecular; Cucurbitaceae; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Glycine; Kinetics; Molecular Sequence Data; Polymerase Chain Reaction; Protein Binding; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine; Serine Proteinase Inhibitors; Serpins; Thrombin; Time Factors; Trypsin; Valine | 2000 |
Lack of proteasome active site allostery as revealed by subunit-specific inhibitors.
Topics: Allosteric Regulation; Animals; Binding Sites; Cattle; Cell Division; Cells, Cultured; Chymotrypsin; Cysteine Endopeptidases; Endopeptidases; Epoxy Compounds; Humans; Hydrolysis; Ketones; Kinetics; Models, Biological; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Subunits; Recombinant Fusion Proteins; Serine; Substrate Specificity; Transfection | 2001 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptides; Animals; Aspartic Acid; Chymotrypsin; Coloring Agents; Endopeptidases; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Acid; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; PC12 Cells; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Serine | 2001 |
The Hemophilus influenzae Hap autotransporter is a chymotrypsin clan serine protease and undergoes autoproteolysis via an intermolecular mechanism.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Outer Membrane Proteins; Binding Sites; Biological Transport; Catalysis; Catalytic Domain; Chymotrypsin; Conserved Sequence; Genetic Techniques; Haemophilus influenzae; Histidine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Serine Endopeptidases; Time Factors | 2001 |
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.
Topics: Amino Acid Sequence; Anions; Arterivirus; Aspartic Acid; Binding Sites; Catalytic Domain; Chymotrypsin; Crystallography, X-Ray; Histidine; Models, Genetic; Models, Molecular; Molecular Sequence Data; Open Reading Frames; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Serine Endopeptidases | 2002 |
Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
Topics: Animals; Binding Sites; Cell Cycle; Cell Cycle Proteins; Cell Line; Centrosome; Chymotrypsin; Flow Cytometry; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Insecta; Kinetics; Microscopy, Fluorescence; Mitosis; Mutation; Peptides; Phosphorylation; Polo-Like Kinase 1; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; S Phase; Serine; Threonine; Time Factors; Transfection; Xenopus; Xenopus Proteins | 2002 |
Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity.
Topics: Amino Acid Sequence; Animals; Bacteriophage T4; Binding Sites; Cations; Cell Adhesion; Chymotrypsin; Conserved Sequence; Cysteine; Disulfides; Dithiothreitol; Dose-Response Relationship, Drug; Glucosyltransferases; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Mutation; N-Acetylglucosaminyltransferases; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Polysaccharides; Protein Folding; Protein Isoforms; Recombinant Proteins; Reducing Agents; Sequence Homology, Amino Acid; Serine; Serine Endopeptidases; Sulfhydryl Compounds; Time Factors; Trypsin | 2003 |
Serine phosphoric acid from diisopropylphosphoryl chymotrypsin.
Topics: Chymotrypsin; Endopeptidases; Hydrolases; Isoflurophate; Peptide Hydrolases; Phosphoric Acids; Serine | 1953 |
[Amino acid sequence in the area of the reactive serine group of the chymotrypsin molecule].
Topics: Amino Acid Sequence; Amino Acids; Chymotrypsin; Endopeptidases; Hydrolases; Peptide Hydrolases; Serine | 1955 |
Structures of some acetyl-serine peptides from acetyl-chymotrypsin.
Topics: Chymotrypsin; Hematologic Tests; Peptides; Serine | 1960 |
Amino acids involved in the action of chymotrypsin.
Topics: Amino Acids; Chymotrypsin; Histidine; Lysine; Methionine; Serine; Tryptophan | 1962 |
CORRELATION OF STRUCTURE AND FUNCTION IN ENZYME ACTION.
Topics: Carboxypeptidases; Chemical Phenomena; Chemistry; Chymotrypsin; Enzymes; Metabolism; Research; Ribonucleases; Serine | 1963 |
ROLE OF SERINE IN CHYMOTRYPSIN ACTION. CONVERSION OF THE ACTIVE SERINE TO DEHYDROALANINE.
Topics: Alanine; Chymotrypsin; Proteins; Research; Serine | 1963 |
ANABOLIC RESPONSES OF DIAPHRAGM MUSCLE TO INSULIN AND TO OTHER PANCREATIC PROTEINS.
Topics: Carbohydrate Metabolism; Carboxypeptidases; Chymotrypsin; Diaphragm; Endopeptidases; Glucose; Glycogen; Hydrolases; Insulin; Metabolism; Muscle, Smooth; Muscles; Pepsin A; Pharmacology; Proline; Proteins; Rats; Research; Serine; Trypsin; Xylose | 1964 |
HEAVY ATOM LABELLING OF THE SERINE OF THE ACTIVE CENTRE OF CHYMOTRYPSIN: PIPSYL-CHYMOTRYPSIN.
Topics: Chymotrypsin; Enzyme Inhibitors; Pyruvates; Research; Serine; Spectrum Analysis; X-Ray Diffraction | 1964 |
RADIATION CHEMISTRY OF PROTEINS. II. ENZYMIC ACTIVITY AND DEUTERIUM EXCHANGE PROPERTIES OF LYSOZYME AND ALPHA-CHYMOTRYPSIN.
Topics: Amino Acids; Cesium Isotopes; Chromatography; Chymotrypsin; Deuterium; Muramidase; Proteins; Radiation Effects; Research; Serine; Tryptophan | 1964 |
THE ACTIVE CENTER IN ENZYME ACTION.
Topics: Amino Acids; Biochemical Phenomena; Biochemistry; Carbon Isotopes; Catalysis; Chymotrypsin; Kinetics; Research; Serine; Sulfhydryl Compounds; Sulfites; Sulfonic Acids; Thioglycolates; Toluene | 1964 |
MUTATIONALLY INDUCED AMINO ACID SUBSTITUTIONS IN A TRYPTIC PEPTIDE OF THE TRYPTOPHAN SYNTHETASE A PROTEIN.
Topics: Alanine; Amino Acid Substitution; Amino Acids; Aspartic Acid; Autoanalysis; Bacterial Proteins; Biochemical Phenomena; Biochemistry; Carboxypeptidases; Chromatography; Chromosome Mapping; Chymotrypsin; Escherichia coli; Genetic Code; Glycine; Hydro-Lyases; Isoleucine; Leucyl Aminopeptidase; Molecular Biology; Mutation; Papain; Peptides; Protein Hydrolysates; Research; Serine; Trypsin; Tryptophan Synthase | 1965 |
THE SEQUENCE OF AMINO ACIDS IN THE VICINITY OF THE ACTIVE SERINE RESIDUE OF PORCINE TRYPSIN.
Topics: Amino Acids; Animals; Biochemical Phenomena; Biochemistry; Chromatography; Chymotrypsin; Peptides; Research; Serine; Swine; Trypsin | 1965 |
ENZYMATIC HYPOGLYCEMIA IN ALLOXAN DIABETIC RATS.
Topics: Alloxan; Animals; Chymotrypsin; Diabetes Mellitus, Experimental; Histidine; Hypoglycemia; Pharmacology; Rats; Research; Serine; Trypsin | 1965 |
SULFONYL FLUORIDES AS INHIBITORS OF ESTERASES. 3. IDENTIFICATION OF SERINE AS THE SITE OF SULFONYLATION IN PHENYLMETHANESULFONYL ALPHA-CHYMOTRYPSIN.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Enzyme Inhibitors; Esterases; Hydrogen-Ion Concentration; Research; Serine; Sulfinic Acids; Sulfonic Acids | 1965 |
SUPPRESSION OF A COAT PROTEIN MUTANT OF THE BACTERIOPHAGE F2.
Topics: Alkaline Phosphatase; Autoradiography; Capsid Proteins; Chymotrypsin; Coliphages; Dextrans; Genetic Code; Glutamine; Molecular Biology; Mutant Proteins; Mutation; Peptides; Phenylalanine; Proteins; Research; Serine; Viral Proteins | 1965 |
Phosphoserylglycine from diisopropylphosphoryl chymotrypsin and inversion of its peptide sequence by acid.
Topics: Amino Acid Sequence; Chymotrypsin; Endopeptidases; Peptide Hydrolases; Peptides; Serine | 1955 |
The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site.
Topics: ATP-Dependent Proteases; Binding Sites; Catalysis; Chymotrypsin; Crystallization; Crystallography, X-Ray; Escherichia coli Proteins; Heat-Shock Proteins; Lysine; Models, Molecular; Molecular Structure; Protease La; Protein Binding; Protein Folding; Protein Structure, Secondary; Serine; Serine Endopeptidases | 2004 |
Proteolytic sensitivity of a recombinant phospholipase D from cabbage: identification of loop regions and conformational changes.
Topics: Amino Acid Sequence; Brassica; Calcium; Chymotrypsin; Hot Temperature; Lysine; Molecular Sequence Data; Peptide Fragments; Phospholipase D; Protein Conformation; Protein Processing, Post-Translational; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thermolysin; Trypsin | 2003 |
Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Benzamidines; Chymotrypsin; Chymotrypsinogen; Glycine; Kinetics; Molecular Sequence Data; Mutation; Peptide Hydrolases; Protein Conformation; Rats; Serine; Substrate Specificity; Trypsin; Trypsin Inhibitors | 2004 |
Temperature dependence of the thrombin-catalyzed proteolysis of prothrombin.
Topics: Animals; Arginine; Blood Coagulation; Catalysis; Chymotrypsin; Hydrolysis; Kinetics; Peptide Fragments; Protein Binding; Prothrombin; Serine; Temperature; Threonine; Thrombin; Trypsin | 2004 |
Identification of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Capsid; Cell-Free System; Chymotrypsin; Hepacivirus; In Vitro Techniques; Microscopy, Electron; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Rabbits; Sequence Deletion; Sequence Homology, Amino Acid; Serine; Viral Core Proteins; Virus Assembly | 2005 |
Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition.
Topics: Animals; Cattle; Chymotrypsin; Crystallography, X-Ray; Escherichia coli; Factor VIIa; Fibrinolysin; Glycoproteins; Humans; Leucine; Models, Molecular; Neoplasm Metastasis; Oxygen; Phenylalanine; Protease Inhibitors; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Static Electricity; Trypsin | 2005 |
Dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell-free system.
Topics: Animals; Cell Cycle; Cell-Free System; Chromatin; Chymotrypsin; Cytosol; DNA-Binding Proteins; Glutathione Transferase; Humans; Mass Spectrometry; Membrane Proteins; Mitosis; Muscular Dystrophy, Emery-Dreifuss; Mutation; Nuclear Proteins; Oocytes; Peptides; Phosphopeptides; Phosphorylation; Point Mutation; Protein Binding; Recombinant Fusion Proteins; Serine; Spectrometry, Mass, Electrospray Ionization; Thymopoietins; Trypsin; Xenopus | 2005 |
Unusual structural features of the bacteriophage-associated hyaluronate lyase (hylp2).
Topics: Bacteriophages; Binding Sites; Catalytic Domain; Chromatography; Chymotrypsin; Circular Dichroism; Cross-Linking Reagents; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutaral; Glycosaminoglycans; Glycoside Hydrolases; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Weight; Plasmids; Polysaccharide-Lyases; Protein Conformation; Protein Denaturation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Spectrometry, Mass, Electrospray Ionization; Streptococcus pyogenes; Substrate Specificity; Tryptophan | 2006 |
Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.
Topics: Acrylic Resins; Administration, Oral; Amino Acid Sequence; Animals; Cell Membrane Permeability; Chitin; Chymotrypsin; Cyclotides; Cysteine; Cystine; Cystine Knot Motifs; Diffusion Chambers, Culture; Drug Carriers; Drug Stability; Intestinal Absorption; Molecular Sequence Data; Plant Proteins; Protein Conformation; Protein Engineering; Rats; Recombinant Fusion Proteins; Serine; Swine; Time Factors; Trypsin; Trypsin Inhibitor, Bowman-Birk Soybean | 2007 |
13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes.
Topics: Animals; Binding Sites; Catalysis; Cattle; Chymotrypsin; Glyoxal; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Ions; Magnetic Resonance Spectroscopy; Serine; Surface Plasmon Resonance; Temperature | 2007 |
LMP2-specific inhibitors: chemical genetic tools for proteasome biology.
Topics: Adenocarcinoma; Animals; Catalytic Domain; Cell Line, Tumor; Chymotrypsin; Cysteine Endopeptidases; Humans; Male; Mice; Molecular Probes; Neovascularization, Pathologic; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Serine | 2007 |
Inhibitory properties of the P1 Tyr variant of antithrombin.
Topics: alpha 1-Antitrypsin; Amino Acid Substitution; Antithrombin III; Antithrombins; Binding Sites; Blood Coagulation; Catalytic Domain; Cell Line, Tumor; Chymotrypsin; Factor Xa; Humans; Models, Molecular; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Serine Endopeptidases; Serine Proteinase Inhibitors; Serpins; Thrombin | 2010 |
Structural relationship between the active sites of β-lactam-recognizing and amidase signature enzymes: convergent evolution?
Topics: Amidohydrolases; Amino Acid Sequence; Bacteria; beta-Lactams; Catalytic Domain; Chymotrypsin; Escherichia coli; Evolution, Molecular; Models, Molecular; Peptide Hydrolases; Protein Folding; Serine; Serine Proteases; Staphylococcus aureus; Streptococcus pneumoniae; Streptomyces; Substrate Specificity | 2010 |
Importance of tetrahedral intermediate formation in the catalytic mechanism of the serine proteases chymotrypsin and subtilisin.
Topics: Biocatalysis; Catalytic Domain; Chymotrypsin; Glyoxal; Hydrogen Bonding; Hydrogen-Ion Concentration; Oligopeptides; Protease Inhibitors; Serine; Subtilisin | 2012 |
Purification and characterization of a novel fibrinolytic α chymotrypsin like serine metalloprotease from the edible mushroom, Lyophyllum shimeji.
Topics: Agaricales; Amino Acid Sequence; Chromatography, Gel; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Fibrin; Fibrinogen; Fibrinolysis; Hydrogen-Ion Concentration; Metalloproteases; Molecular Weight; Serine; Temperature; Thrombosis | 2014 |
Hemiacetal stabilization in a chymotrypsin inhibitor complex and the reactivity of the hydroxyl group of the catalytic serine residue of chymotrypsin.
Topics: Animals; Biocatalysis; Catalytic Domain; Cattle; Chymotrypsin; Glyoxal; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Protease Inhibitors; Serine; Solutions; Stereoisomerism; Thermodynamics | 2014 |
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Topics: Chronic Disease; Chymotrypsin; Genetic Predisposition to Disease; Humans; Mutation; Pancreatitis; Serine; Trypsin Inhibitor, Kazal Pancreatic | 2016 |
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Topics: Animals; Benzoxazines; Catalytic Domain; Cattle; Chymotrypsin; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Drug Discovery; Endopeptidases; Enzyme Assays; Escherichia coli; Escherichia coli Proteins; Humans; Membrane Proteins; Molecular Docking Simulation; Mutation; Serine; Serine Proteinase Inhibitors; Styrenes; Transforming Growth Factor alpha | 2018 |
Adaptation of
Topics: Animals; Chymotrypsin; Glycine max; Larva; Moths; Protease Inhibitors; Serine; Serine Proteases; Trypsin; Up-Regulation | 2022 |