serine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

serine has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (41.94)18.2507
2000's13 (41.94)29.6817
2010's4 (12.90)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Deuel, TF; Shawver, LK1
Blenis, J; Chen-Kiang, S; Li, HC; Schindler, C; Zhang, X1
Terrian, DM; Ways, DK1
Jost, E; Leukel, M1
Buczyłko, J; Ohguro, H; Palczewski, K; Rudnicka-Nawrot, M; Taylor, JA; Walsh, KA; Zhao, X1
Adachi, M; Imai, K; Minami, Y; Miyazaki, T; Reed, JC; Sekiya, M; Takayama, S; Taniguchi, T; Torigoe, T1
Ikeuchi, Y; Matsuoka, T; Nishizaki, T; Sumikawa, K1
Blenis, J; Chung, J; Grammer, TC; Uchida, E1
Evans, DL; Jaso-Friedmann, L; Leary, JH1
Gondal, JA; Grundke-Iqbal, I; Iqbal, K; Sironi, JJ; Wu, Q; Yen, SH1
Nagumo, H; Sakurada, K; Sasaki, Y; Seto, M; Walsh, MP1
Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M1
Cao, X; Jain, N; Kee, WH; Li, W; Zhang, T1
Cantrell, D; Decker, T; Lafont, V1
Furuya, K; Hiraoka, H; Ikenoya, M; Ikuhara, T; Nagumo, H; Sakurada, K; Sasaki, Y1
Berton, MT; Wick, KR1
Bennecib, M; Gong, CX; Grundke-Iqbal, I; Iqbal, K1
Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C1
Abe, K; Higashi, N; Hirai, M; Hirano, T; Miki, T; Mizuno, K; Nakajima, K; Sekimoto, T1
Bean, LJ; Chernov, MV; Lerner, N; Stark, GR1
Park, SH; Rui, H; Waxman, DJ; Yamashita, H1
Fukunaga, K; Furuya, K; Hiraoka, H; Ikuhara, T; Kato, H; Matsumura, F; Matsuo, YI; Miyamoto, E; Nagumo, H; Naito, Y; Sakurada, K; Sasaki, Y; Yamakita, Y1
Guo, J; Meng, F; Song, B; Yan, X; Zhang, G1
Fu, XZ; Meng, FJ; Zhang, GY; Zhang, QG1
Meng, FJ; Song, B; Yan, XB; Zhang, GY1
Czervionke, BL; Higley, MJ; Malenka, RC; Sabatini, BL; Steiner, P; Xu, W1
Alessi, DR; Deak, M; Dzamko, N; Hentati, F; Nichols, RJ; Prescott, AR; Reith, AD1
Rong, LQ; Wang, K; Wei, XE; Zhang, FY; Zhang, QX1
Greggio, E; Longo, F; Morari, M; Russo, I; Shimshek, DR1
Abbott, TB; Chung, L; Colangelo, CM; Gulcicek, EE; Lam, TT; Nairn, AC; Rich, MT; Stone, KL; Taylor, JR; Torregrossa, MM1
Borczyk, M; Nowacka, A; Radwanska, K; Salamian, A; Wójtowicz, T; Włodarczyk, J1

Reviews

1 review(s) available for serine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
Receptor associated phosphorylation following monoclonal antibody or synthetic peptide binding to nonspecific cytotoxic cells.
    Journal of receptor and signal transduction research, 1998, Volume: 18, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Cytotoxicity, Immunologic; Genistein; Ictaluridae; Isoquinolines; Killer Cells, Natural; Molecular Sequence Data; Oxazolone; Peptides; Phosphorylation; Phosphoserine; Protein Kinase C; Quinolines; Serine; Sulfonamides; Tetradecanoylphorbol Acetate

1998

Other Studies

30 other study(ies) available for serine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
    Biochemical and biophysical research communications, 1990, Mar-30, Volume: 167, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine

1990
Requirement of serine phosphorylation for formation of STAT-promoter complexes.
    Science (New York, N.Y.), 1995, Mar-31, Volume: 267, Issue:5206

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Nucleus; Ciliary Neurotrophic Factor; Cytoplasm; DNA; DNA-Binding Proteins; Humans; Interleukin-6; Isoquinolines; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Phosphorylation; Piperazines; Promoter Regions, Genetic; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Threonine; Trans-Activators; Tumor Cells, Cultured; Tyrosine

1995
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
    Journal of neurochemistry, 1995, Volume: 64, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine

1995
Two conserved serines in the nuclear localization signal flanking region are involved in the nuclear targeting of human lamin A.
    European journal of cell biology, 1995, Volume: 68, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Phosphatase; Alkaline Phosphatase; Alkaloids; Amino Acid Sequence; Animals; Biological Transport; Cell Nucleus; Chick Embryo; Consensus Sequence; Enzyme Inhibitors; Humans; Isoquinolines; Kinetics; Lamin Type A; Lamins; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Protein Sorting Signals; Serine; Staurosporine

1995
Structural and enzymatic aspects of rhodopsin phosphorylation.
    The Journal of biological chemistry, 1996, Mar-01, Volume: 271, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; Insecta; Isoquinolines; Kinetics; Light; Mass Spectrometry; Mice; Palmitic Acid; Palmitic Acids; Peptide Fragments; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Protein Kinases; Recombinant Proteins; Rhodopsin; Rod Cell Outer Segment; Serine; Tetradecanoylphorbol Acetate; Transfection

1996
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain.
    Blood, 1996, Dec-01, Volume: 88, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Carrier Proteins; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Hematopoietic Stem Cells; Humans; Interleukin-2; Isoflavones; Janus Kinase 3; Lymphocytes; Mice; Phosphorylation; Phytohemagglutinins; Polyenes; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-2; RNA, Messenger; Serine; Signal Transduction; Sirolimus; Stimulation, Chemical; Tacrolimus; Transcription Factors; Transfection

1996
Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II.
    Neuroreport, 1997, Feb-10, Volume: 8, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Kinetics; Macromolecular Substances; Maleimides; Mutagenesis, Site-Directed; Oleic Acid; Oocytes; Point Mutation; Protein Kinase C; Receptors, Nicotinic; Recombinant Proteins; Serine; Torpedo; Xenopus laevis

1997
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.
    Molecular and cellular biology, 1997, Volume: 17, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; COS Cells; DNA-Binding Proteins; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Substrate Specificity; Trans-Activators; Tyrosine

1997
Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.
    FEBS letters, 1998, Oct-09, Volume: 436, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Phosphorylase Kinase; Phosphorylation; Rats; Recombinant Proteins; Serine; Substrate Specificity; tau Proteins

1998
HA1077, a protein kinase inhibitor, inhibits calponin phosphorylation on Ser175 in porcine coronary artery.
    European journal of pharmacology, 1998, Nov-06, Volume: 360, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium-Binding Proteins; Calponins; Carrier Proteins; Coronary Vessels; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Microfilament Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Serine; Swine; Vasodilator Agents

1998
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
    Archives of biochemistry and biophysics, 1999, Mar-01, Volume: 363, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine

1999
Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
    The Journal of biological chemistry, 1999, Aug-20, Volume: 274, Issue:34

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Humans; Interleukin-6; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Kinase C; Serine; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation

1999
Antigen receptor signal transduction: activating and inhibitory antigen receptors regulate STAT1 serine phosphorylation.
    European journal of immunology, 2000, Volume: 30, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; DNA; DNA-Binding Proteins; Humans; Jurkat Cells; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, IgG; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine

2000
Rho-associated kinase phosphorylates MARCKS in human neuronal cells.
    Biochemical and biophysical research communications, 2001, Jan-26, Volume: 280, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Cell Line; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Recombinant Proteins; rho-Associated Kinases; Serine

2001
IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes.
    Molecular immunology, 2000, Volume: 37, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Female; Interleukin-4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Serine; STAT6 Transcription Factor; Trans-Activators; Tyrosine

2000
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
    FEBS letters, 2001, Feb-09, Volume: 490, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation

2001
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
    Oncogene, 2001, Jan-11, Volume: 20, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured

2001
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
    Oncogene, 2001, Jun-14, Volume: 20, Issue:27

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cytokine Receptor gp130; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-6; Liver Neoplasms; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2001
Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation.
    The Journal of biological chemistry, 2001, Aug-24, Volume: 276, Issue:34

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrolysis; Mice; Nuclear Proteins; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Ubiquitins

2001
Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Caseins; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Growth Hormone; Hepatocytes; Humans; Milk Proteins; Mutagenesis, Site-Directed; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Serine; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tumor Suppressor Proteins

2001
Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
    The Journal of biological chemistry, 2002, Nov-22, Volume: 277, Issue:47

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Bradykinin; Brain Chemistry; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; COS Cells; Enzyme Inhibitors; Molecular Sequence Data; p21-Activated Kinases; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Sequence Alignment; Serine; Synapsins

2002
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
    Neuroscience letters, 2003, Oct-09, Volume: 349, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; GTPase-Activating Proteins; Hippocampus; Male; MAP Kinase Signaling System; Phosphorylation; ras Proteins; Rats; Rats, Sprague-Dawley; Reaction Time; Serine; Synapses; Up-Regulation

2003
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.
    Neuroscience research, 2004, Volume: 48, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Densitometry; Dopamine Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia-Ischemia, Brain; Male; Nifedipine; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine; Synaptosomes; Time Factors; Trifluoperazine

2004
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine

2004
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.
    Neuron, 2008, Dec-10, Volume: 60, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Dendritic Spines; Disks Large Homolog 4 Protein; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamates; Green Fluorescent Proteins; Hippocampus; Indoles; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Membrane Proteins; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phosphorylation; Piperazines; Point Mutation; Protein Structure, Tertiary; Protein Transport; Rats; Rats, Sprague-Dawley; Serine; Time Factors

2008
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
    The Biochemical journal, 2010, Sep-15, Volume: 430, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 14-3-3 Proteins; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cells, Cultured; Cytoplasm; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Humans; Inclusion Bodies; Indoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Microscopy, Fluorescence; Middle Aged; Mutation; Parkinson Disease; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyrroles; Serine; Sunitinib; Swiss 3T3 Cells

2010
Fasudil hydrochloride protects neurons in rat hippocampal CA1 region through inhibiting GluR6-MLK3-JNKs signal pathway.
    Cell biochemistry and biophysics, 2014, Volume: 70, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CA1 Region, Hippocampal; Caspase 3; Cytoprotection; Enzyme Activation; GluK2 Kainate Receptor; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Reperfusion Injury; Serine

2014
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
    Neurobiology of disease, 2014, Volume: 71

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycine; Humans; Hyperkinesis; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; NIH 3T3 Cells; Protein Serine-Threonine Kinases; Serine; Time Factors

2014
Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 07-20, Volume: 36, Issue:29

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Conditioning, Operant; Cues; Enzyme Inhibitors; Extinction, Psychological; HEK293 Cells; Humans; Male; Memory; Phosphorylation; Proteomics; Rats; Rats, Sprague-Dawley; Self Administration; Serine; Signal Transduction; Sulfonamides

2016
PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD.
    Scientific reports, 2020, 02-06, Volume: 10, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Disks Large Homolog 4 Protein; Down-Regulation; Hippocampus; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Phosphorylation; Post-Synaptic Density; Primary Cell Culture; Rats; Serine; Synaptic Potentials

2020