seratrodast has been researched along with thromboxane a2 in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (58.33) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ninomiya, I; Sada, K; Shirai, M | 1 |
| Arimura, A; Iwama, T; Koda, A; Kumimoto, M; Nagai, H; Yoshitake, K | 1 |
| Fujimura, M; Matsuda, T; Miyake, Y; Saito, M; Sakamoto, S | 1 |
| Adachi, M; Idaira, K; Imai, T; Maeda, M; Saito, C; Suganuma, T; Takahashi, T; Tsuji, A; Yamaguchi, H | 1 |
| Adachi, M; Hiyama, T; Idaira, K; Imai, T; Maeda, M; Saito, C; Suganuma, T; Takahashi, T; Tsuji, A | 1 |
| Imura, Y; Nishikawa, K; Terashita, Z | 1 |
| Ashida, Y; Matsumoto, T; Tsukuda, R | 1 |
| Ashida, Y; Iwasa, S; Kurokawa, T; Matsumoto, T; Sasada, R | 1 |
| Granneman, GR; Hussein, Z; Locke, CS; Orchard, MA; Ringham, GL; Samara, E | 1 |
| Ashida, Y; Matsumoto, T | 2 |
| Ashida, Y; Horiba, M; Itoh, Y; Kohno, S; Ohata, K; Shindoh, J; Takagi, K | 1 |
| Akiyama, K; Endo, S | 1 |
| Dennisen, JF; Dubberke, E; Kumar, GN; Roberts, E; Rodrigues, AD | 1 |
| Ashida, Y; Fukuda, S; Matsumoto, T; Nagaya, H; Nakayama, T; Yamasaki, M | 1 |
| Hamana, K; Matsuzaki, S; Matsuzaki, Y; Mori, M; Nagamine, T; Sugimoto, H | 1 |
| Aizawa, H; Fukuyama, S; Hara, N; Inoue, H; Koto, H; Matsumoto, K; Nakano, H; Yoshida, M | 1 |
| Takami, M; Tsukada, W | 1 |
| Ashida, Y; Matsumoto, T; Shiraishi, M; Terao, S | 1 |
| Kohno, S; Nabe, T; Tomioka, H; Yamashita, K | 1 |
| Abo, M; Fujimura, M; Hashimoto, T; Ishiura, Y; Kamio, Y; Matsuda, T; Myou, S | 1 |
| Terao, S | 1 |
| Kotajima, R; Muramatsu, H; Sato, T | 1 |
| Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sasaki, K; Yamasaki, M | 1 |
| Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sakura, Y; Sasaki, K; Yamasaki, ML | 1 |
| Adachi, M; Minoguchi, K | 1 |
| Fujino, T; Kawabe, J; Kikuchi, K; Ohsaki, Y; Shiokoshi, T | 1 |
| Fukumoto, K; Hirose, M; Horiguchi, T; Kondo, R; Shiga, M; Tachikawa, S | 1 |
| Fukuoka, T; Inase, N; Miyake, S; Tojo, N; Umino, T; Yoshizawa, Y | 1 |
| Benoit, P; de Leval, X; Delarge, J; Dogné, JM; Masereel, B | 1 |
| Kohno, S; Mizutani, N; Nabe, T; Nakanishi, Y; Takenaka, H | 1 |
| Dogné, JM; Masereel, B; Rolin, S | 1 |
| Jiang, S; Kamei, C; Kishi, Y; Nakano, Y; Yatsuzuka, R | 1 |
| Iwasaki, H; Kato, T; Miyagawa, N; Shibata, T; Tanaka, M; Wakitani, K | 1 |
| Jin, H; Kawasaki, H; Kitamura, Y; Koyama, T; Sun, P; Takatori, S; Tangsucharit, P; Zamami, Y | 1 |
| Jaggi, AS; Randhawa, PK; Sharma, R; Singh, N | 1 |
6 review(s) available for seratrodast and thromboxane a2
| Article | Year |
|---|---|
[Thromboxane A2 receptor antagonist in asthma therapy].
Topics: Asthma; Benzoquinones; Bridged Bicyclo Compounds; Bronchi; Bronchial Hyperreactivity; Carbazoles; Fatty Acids, Monounsaturated; Heptanoic Acids; Humans; Prostaglandins; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1996 |
[Thromboxane A2 antagonist--discovery of seratrodast].
Topics: Animals; Anti-Asthmatic Agents; Benzoquinones; Clinical Trials as Topic; Dogs; Guinea Pigs; Heptanoic Acids; Humans; Lipoxygenase Inhibitors; Male; Rabbits; Structure-Activity Relationship; Thromboxane A2 | 1999 |
[Thromboxane A2].
Topics: Anti-Asthmatic Agents; Benzoquinones; Drug Design; Heptanoic Acids; Humans; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2000 |
[Thromboxane A2 synthase inhibitor and receptor antagonist].
Topics: Asthma; Benzoquinones; Bronchi; Bronchial Hyperreactivity; Eosinophils; Heptanoic Acids; Humans; Methacrylates; Practice Guidelines as Topic; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2001 |
Thromboxane A2 inhibition: therapeutic potential in bronchial asthma.
Topics: Anti-Asthmatic Agents; Asthma; Benzoquinones; Carbazoles; Heptanoic Acids; Humans; Methacrylates; Molecular Structure; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase | 2002 |
Prostanoids as pharmacological targets in COPD and asthma.
Topics: Animals; Asthma; Benzoquinones; Carbazoles; Enzyme Inhibitors; F2-Isoprostanes; Heptanoic Acids; Humans; Methacrylates; Prostaglandin Antagonists; Prostaglandin D2; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase | 2006 |
5 trial(s) available for seratrodast and thromboxane a2
| Article | Year |
|---|---|
Effect of a thromboxane A2 receptor antagonist (AA-2414) on bronchial hyperresponsiveness to methacholine in subjects with asthma.
Topics: Adult; Aged; Asthma; Benzoquinones; Bronchi; Dose-Response Relationship, Drug; Drug Synergism; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Male; Methacholine Chloride; Middle Aged; Quinones; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Vital Capacity | 1991 |
Characterization of the pharmacokinetics and pharmacodynamics of a new oral thromboxane A2-receptor antagonist AA-2414 in normal subjects: population analysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Oral; Adolescent; Adult; Benzoquinones; Body Weight; Double-Blind Method; Heptanoic Acids; Humans; Leukotriene B4; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinones; Receptors, Thromboxane; Thromboxane A2; Thromboxane B2 | 1994 |
Effect of leukotriene and thromboxane antagonist on propranolol-induced bronchoconstriction.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Asthma; Benzoquinones; Bronchoconstriction; Chromones; Double-Blind Method; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Leukotriene Antagonists; Male; Middle Aged; Propranolol; Thromboxane A2; Vital Capacity | 1999 |
Study on the usefulness of seratrodast in the treatment of chronic pulmonary emphysema.
Topics: Aged; Aged, 80 and over; Anti-Asthmatic Agents; Benzoquinones; Carbon Dioxide; Chronic Disease; Dyspnea; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Immunoglobulin E; Male; Middle Aged; Oxygen; Peak Expiratory Flow Rate; Prostaglandin Antagonists; Pulmonary Emphysema; Respiratory Function Tests; Smoking; Thromboxane A2; Thromboxane B2 | 2002 |
The effect of seratrodast on eosinophil cationic protein and symptoms in asthmatics.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Benzoquinones; Blood Proteins; Bronchial Hyperreactivity; Cross-Over Studies; Eosinophil Granule Proteins; Eosinophils; Female; Heptanoic Acids; Humans; Inflammation Mediators; Male; Peak Expiratory Flow Rate; Ribonucleases; Sputum; Thromboxane A2 | 2003 |
25 other study(ies) available for seratrodast and thromboxane a2
| Article | Year |
|---|---|
Thromboxane A2/endoperoxide receptors mediate cholinergic constriction of rabbit lung microvessels.
Topics: Acetylcholine; Animals; Benzoquinones; Blood Pressure; Cholinergic Fibers; Electric Stimulation; Heptanoic Acids; Indomethacin; Lung; Microcirculation; Quinones; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxanes; Vagus Nerve; Vasoconstriction | 1992 |
The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Airway Resistance; Anaphylaxis; Animals; Antibodies, Heterophile; Benzoquinones; Bridged Bicyclo Compounds; Bronchoalveolar Lavage Fluid; Fatty Acids, Monounsaturated; Guinea Pigs; Heptanoic Acids; Histamine; Leukocyte Count; Male; Platelet Count; Quinones; Receptors, Prostaglandin; Receptors, Thromboxane; SRS-A; Thromboxane A2; Thromboxane B2 | 1992 |
[The effect of a specific thromboxane A2 antagonist, AA-2414 on airway hyperresponsiveness induced by ozone exposure in dogs].
Topics: Animals; Benzoquinones; Bronchi; Bronchoalveolar Lavage Fluid; Dogs; Environmental Exposure; Heptanoic Acids; Leukocyte Count; Neutrophils; Ozone; Quinones; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1991 |
[The role of thromboxane A2 in the development of airway responsiveness after platelet activating factor inhalation in dogs].
Topics: Administration, Inhalation; Airway Resistance; Animals; Benzoquinones; Bronchi; Bronchoalveolar Lavage Fluid; Dogs; Female; Heptanoic Acids; Leukocyte Count; Methacholine Chloride; Platelet Activating Factor; Quinones; Thromboxane A2 | 1991 |
The role of thromboxane (TX) A2 in rabbit arterial thrombosis induced by endothelial damage.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Carotid Artery Thrombosis; Disease Models, Animal; Endothelium, Vascular; Fatty Acids, Monounsaturated; Heptanoic Acids; Male; Platelet Aggregation; Pyridines; Quinones; Rabbits; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1990 |
Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig.
Topics: Acetylcholine; Airway Resistance; Animals; Antibodies; Asthma; Benzoquinones; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Fatty Acids, Monounsaturated; Guinea Pigs; Heptanoic Acids; Leukocytes; Male; Methacrylates; Ovalbumin; Pyridines; Theophylline; Thromboxane A2 | 1994 |
Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Benzoquinones; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Guinea Pigs; Heptanoic Acids; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Plasmids; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thromboxane A2; Trachea | 1994 |
Inhibition of antigen-induced airway hyperresponsiveness by a thromboxane A2 receptor antagonist (AA-2414) in Ascaris suum-allergic dogs.
Topics: Acetylcholine; Administration, Inhalation; Animals; Antigens, Helminth; Ascaris suum; Benzoquinones; Bronchoconstriction; Dogs; Female; Heptanoic Acids; Hypersensitivity; Male; Quinones; Receptors, Thromboxane; Respiratory System; Thromboxane A2 | 1993 |
[Inhibitory effects of AA-2414, a thromboxane (Tx) A2 receptor antagonist, on U-46619-, prostaglandin (PG) D2- and 9 alpha, 11 beta PGF2-induced contractions of guinea pig tracheas and isolated human bronchi].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoquinones; Bronchi; Dinoprost; Guinea Pigs; Heptanoic Acids; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Quinones; Receptors, Thromboxane; Thromboxane A2; Trachea | 1993 |
[Inhibitory effect of a thromboxane A2 receptor antagonist, AA-2414, on active oxygen production by alveolar macrophages and polymorphonuclear leukocytes in guinea pigs].
Topics: Animals; Benzoquinones; Guinea Pigs; Heptanoic Acids; Macrophages, Alveolar; Neutrophils; Reactive Oxygen Species; Receptors, Thromboxane; Thromboxane A2 | 1996 |
Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001).
Topics: Anti-Asthmatic Agents; Antibodies; B-Lymphocytes; Benzoquinones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Heptanoic Acids; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Substrate Specificity; Thromboxane A2 | 1997 |
Involvement of thromboxane A2 and histamine in experimental allergic rhinitis of guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antigens; Benzoquinones; Capillary Permeability; Guinea Pigs; Heptanoic Acids; Histamine; Histamine H1 Antagonists; Male; Nasal Mucosa; Phthalazines; Prostaglandin Antagonists; Prostaglandin Endoperoxides, Synthetic; Rhinitis, Allergic, Seasonal; Thromboxane A2 | 1997 |
Effects of eicosanoids on lipopolysaccharide-induced ornithine decarboxylase activity and polyamine metabolism in the mouse liver.
Topics: Alprostadil; Animals; Benzoquinones; Blotting, Northern; Corticosterone; Eicosanoids; Enzyme Induction; Escherichia coli; Heptanoic Acids; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Polyamines; Prostaglandin Antagonists; Putrescine; RNA, Messenger; Shock, Septic; Spermidine; Thromboxane A2 | 1997 |
Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics.
Topics: Anti-Asthmatic Agents; Asthma; Benzoquinones; Bronchial Hyperreactivity; Eosinophils; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Prostaglandin Antagonists; Respiration; Sputum; Thromboxane A2 | 1998 |
A possible involvement of thromboxane A2 and peptide leukotrienes in hyperresponsiveness of Sephadex-treated rat lung parenchyma.
Topics: Animals; Anti-Asthmatic Agents; Benzoquinones; Dextrans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Heptanoic Acids; Imidazoles; Indazoles; Indomethacin; Leukotrienes; Lung; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Serotonin; Tetrahydronaphthalenes; Thromboxane A2 | 1999 |
Repeated antigen inhalations alter chemical mediators that cause asthmatic obstruction in guinea pigs.
Topics: Administration, Inhalation; Airway Obstruction; Aluminum Hydroxide; Animals; Antigens; Asthma; Benzoquinones; Chromones; Eosinophilia; Guinea Pigs; Heptanoic Acids; Histamine H1 Antagonists; Leukotriene Antagonists; Lung; Male; Ovalbumin; Prostaglandin Antagonists; Pyrilamine; Thromboxane A2 | 1999 |
[Correlation between the clinical effects of Seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients].
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Benzoquinones; Female; Heptanoic Acids; Humans; Male; Middle Aged; Prostaglandin Antagonists; Sputum; Thromboxane A2; Thromboxane B2 | 2001 |
Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Benzoquinones; Chromones; Dexamethasone; Guinea Pigs; Heptanoic Acids; Histamine; Histamine Release; Leukotrienes; Male; Nasal Cavity; Nasal Obstruction; Rhinitis, Allergic, Seasonal; Sneezing; Terfenadine; Therapeutic Irrigation; Thromboxane A2 | 2001 |
Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a guinea pig model of allergic rhinitis.
Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antigens; Benzoquinones; Chromones; Dexamethasone; Guinea Pigs; Heptanoic Acids; Kinetics; Leukocyte Count; Leukocytes; Leukotriene Antagonists; Male; Nasal Cavity; Rhinitis, Allergic, Seasonal; Terfenadine; Therapeutic Irrigation; Thromboxane A2 | 2001 |
Downregulation of nitric oxide accumulation by cyclooxygenase-2 induction and thromboxane A2 production in interleukin-1beta-stimulated rat aortic smooth muscle cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Benzoquinones; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Down-Regulation; Enzyme Induction; Heptanoic Acids; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Thromboxane A2 | 2002 |
Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoquinones; Chromones; Guinea Pigs; Heptanoic Acids; Hypersensitivity; Leukotriene D4; Leukotrienes; Male; Nasal Cavity; Thromboxane A2 | 2004 |
Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats.
Topics: Animals; Benzoquinones; Carbazoles; Chromones; Dose-Response Relationship, Drug; Heptanoic Acids; Indoles; Leukotrienes; Male; Membrane Proteins; Phenylcarbamates; Rats; Rats, Inbred BN; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Rhinitis; Sneezing; Sulfonamides; Thromboxane A2; Tosyl Compounds | 2007 |
Two pharmacological phases in antigen-induced immediate airway response in rats.
Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzoquinones; Bronchial Hyperreactivity; Chromones; Heptanoic Acids; Histamine H2 Antagonists; Hypersensitivity, Immediate; Ketotifen; Leukotriene Antagonists; Male; Ovalbumin; p-Methoxy-N-methylphenethylamine; Prednisolone; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 2008 |
Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries.
Topics: Acetamides; Animals; Benzoquinones; Capsaicin; Endothelium, Vascular; Heptanoic Acids; Histamine; Indomethacin; Male; Mesenteric Arteries; Methoxamine; Piperidines; Procaine; Prostaglandins; Pyridines; Rats; Rats, Wistar; Receptors, Histamine H2; Ruthenium Red; Tetrodotoxin; Thromboxane A2; TRPV Cation Channels; Vasoconstriction; Vasodilation | 2012 |
Possible role of thromboxane A2 in remote hind limb preconditioning-induced cardioprotection.
Topics: Animals; Benzoquinones; Creatine Kinase; Female; Heart; Heptanoic Acids; Hindlimb; Ischemic Preconditioning; L-Lactate Dehydrogenase; Male; Methacrylates; Myocardial Infarction; Myocardial Reperfusion Injury; Rats, Wistar; Thromboxane A2; Thromboxane-A Synthase | 2016 |