senktide has been researched along with substance p in 282 studies
| Studies (senktide) | Trials (senktide) | Recent Studies (post-2010) (senktide) | Studies (substance p) | Trials (substance p) | Recent Studies (post-2010) (substance p) |
|---|---|---|---|---|---|
| 292 | 1 | 50 | 17,289 | 277 | 2,010 |
| 292 | 1 | 50 | 23 | 0 | 0 |
| 292 | 1 | 50 | 85 | 0 | 12 |
| Protein | Taxonomy | senktide (IC50) | substance p (IC50) |
|---|---|---|---|
| Substance-P receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Substance-K receptor | Rattus norvegicus (Norway rat) | 0.2 | |
| Substance-K receptor | Homo sapiens (human) | 0.2455 | |
| Substance-P receptor | Homo sapiens (human) | 0.0011 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.125 | |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | 0.148 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (3.90) | 18.7374 |
| 1990's | 136 (48.23) | 18.2507 |
| 2000's | 79 (28.01) | 29.6817 |
| 2010's | 53 (18.79) | 24.3611 |
| 2020's | 3 (1.06) | 2.80 |
| Authors | Studies |
|---|---|
| Brawner, ME; Elshourbagy, NA; Foley, JJ; Giardina, GA; Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Potts, W; Sarau, HM; Schmidt, DB; Webb, EF | 1 |
| Cascieri, MA; Harrison, T; Korsgaard, MP; Sadowski, S; Seabrook, GR; Swain, CJ | 1 |
| Ames, RS; Brawner, ME; Buckley, PT; Elshourbagy, NA; Feild, JA; Foley, JJ; Giardina, GA; Hay, DW; Luttmann, MA; Nuthulaganti, P; Sarau, HM; Schmidt, DB | 1 |
| Dorsett, JA; Mandel, KG; Yau, WM; Youther, ML | 1 |
| Kamiya, H; Nakayama, Y; Saito, R; Takano, Y | 1 |
| Ferretti, JA; Jernigan, RL; Jiang, SP; Sumner, SC | 1 |
| Chang, FY; Lee, SD; Wang, PS; Yeh, GH | 2 |
| Ireland, SJ; Jordan, CC; Wright, IK | 1 |
| Keegan, KD; Pinnock, RD; Woodruff, GN | 1 |
| Clark, D; Elliott, PJ; Hagan, RM; Overton, P | 1 |
| Albus, K; Chao, HH; Hicks, TP | 1 |
| Elliott, PJ; Mason, GS | 1 |
| Culman, J; Itoi, K; Jost, N; Lebrun, C; Stauss, B; Tschöpe, C; Unger, T | 1 |
| Dam, TV; Escher, E; Quirion, R | 1 |
| Guard, S; Maggio, JE; Too, HP; Watling, KJ; Watson, SP | 1 |
| Dourish, CT; Iversen, SD; Stoessl, AJ | 3 |
| Hagio, T; Kamiya, H; Nagashima, A; Takano, Y; Tateishi, K | 1 |
| Hill, DR; Stoessl, AJ | 1 |
| Shinkai, M; Takayanagi, I | 1 |
| Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D | 1 |
| Chorev, M; Devor, M; Gilon, C; Papir-Kricheli, D; Selinger, Z | 1 |
| Lorens, SA; Mitsushio, H; Paris, JM | 2 |
| Ballati, L; Giachetti, A; Giuliani, S; Lecci, A; Maggi, CA; Manzini, S; Patacchini, R; Quartara, L; Renzetti, AR; Rovero, P | 1 |
| Humpel, C; Regoli, D; Saria, A | 1 |
| Barsacchi, P; Criscuoli, M; Lucacchini, A; Renzetti, AR | 1 |
| Gunne, L; Johansson, PE; Liminga, U | 1 |
| Hall, JM; Mitchell, D; Morton, IK | 2 |
| Elliott, PJ; Hagan, RM; Mason, GS; Stephens-Smith, M | 1 |
| Beresford, IJ; Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; Ward, P | 1 |
| Chang, FY; Ouyang, A; Sharp, D | 1 |
| Guard, S; McKnight, AT; Watling, KJ; Watson, SP | 1 |
| Hall, JM; Morton, IK | 1 |
| Hagio, T; Kamiya, H; Nagashima, A; Nakayama, Y; Takano, Y | 1 |
| Bowen, DJ; Yau, WM; Youther, ML | 1 |
| Kawashima, K; Kobayashi, N; Onishi, Y; Otsuka, M; Sakuma, M; Yanagisawa, M; Yoshioka, K | 1 |
| Constantine, JW; Lebel, WS; Woody, HA | 1 |
| Fox, AJ; Morton, IK | 1 |
| Barr, AJ; Bernal, AL; Nimmo, AJ; Watson, SP | 1 |
| Chorev, M; Devor, M; Frey, J; Gilon, C; Laufer, R; Papir-Kricheli, D; Selinger, Z | 1 |
| Chorev, M; Gilon, C; Hanani, M; Selinger, Z | 1 |
| Hamaoka, T; Kamiya, H; Matsuoka, Y; Nagashima, A; Takano, Y; Tateishi, K | 2 |
| Ferretti, JA; Sumner, SC | 1 |
| Guard, S; Watling, KJ; Watson, SP | 1 |
| Hicks, CR; Mizoguchi, H | 1 |
| Brodin, E; Franck, J; Fried, G | 1 |
| Bertrand, PP; Galligan, JJ | 2 |
| Longmore, J; Razzaque, Z | 1 |
| Kamiya, H; Matsumoto, T; Nakayama, Y; Saigo, A; Saito, R; Takano, Y; Tran, M; Yamada, K | 1 |
| Ciccocioppo, R; De Caro, G; Massi, M; Panocka, I; Pompei, P | 1 |
| Beaujouan, JC; Glowinski, J; Petitet, F; Saffroy, M; Torrens, Y | 2 |
| Alberch, J; Arenas, E; Marsal, J; Pérez-Navarro, E | 1 |
| Guo, JZ; Konishi, S; Murakoshi, T; Otsuka, M; Saito, K; Yoshioka, K; Zhao, FY | 2 |
| Frydryszak, H; Polanski, E; Stoessl, AJ | 1 |
| Itoi, K; Lebrun, CJ; Steckelings, U; Unger, T; Wende, P | 1 |
| Giuliani, S; Maggi, CA; Meini, S; Patacchini, R | 2 |
| Baranauskas, G; Fisher, ND; Nistri, A | 1 |
| Chrétien, L; Guillemette, G; Regoli, D | 1 |
| Stoessl, AJ | 1 |
| Corsi, M; Gaviraghi, G; Oliosi, B; Palea, S; Pietra, C; Sugg, E; Trist, DG; Van Amsterdam, FT | 1 |
| Cenarruzabeitia, E; Del Río, J; Lasheras, B; Ramírez, MJ | 2 |
| Boussougou, M; Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Regoli, D | 1 |
| Chung, FZ; Grimson, P; Guard, S; Madden, Z; Pinnock, R; Suman-Chauhan, N; Watling, K; Woodruff, G | 1 |
| Chung, FZ; Hill, DR; Madden, Z; Pinnock, RD; Suman-Chauhan, N; Webdale, L; Woodruff, GN | 1 |
| Giuliani, S; Maggi, CA; Zagorodnyuk, V | 1 |
| Lefebvre, RA; Smits, GJ | 1 |
| Flynn, FW; Smith, ME | 4 |
| Arkinstall, S; Beresford, IJ; Hagan, RM; Ireland, SJ; Seale, PW; Stables, JM; Walsh, DM; Ward, P | 1 |
| Bowery, BJ; Hill, RG; Seabrook, GR | 1 |
| Bentley, GN; Gent, JP | 1 |
| Ciccocioppo, R; Gessa, GL; Massi, M; Panocka, I; Stefanini, E | 1 |
| Ciccocioppo, R; de Caro, G; Massi, M; Panocka, I; Polidori, C; Pompei, P | 1 |
| Barthò, L; Holzer, P; Maggi, CA; Patacchini, R | 1 |
| Chizh, BA; Cumberbatch, MJ; Headley, PM | 1 |
| Burcher, E; Geraghty, DP | 1 |
| Grider, JR; Jin, JG; Makhlouf, GM; Misra, S | 1 |
| Boden, PR; Norris, SK; Woodruff, GN | 1 |
| Dalforno, G; Gaviraghi, G; Hagan, RM; Palea, S; Pietra, C; Trist, DG | 1 |
| Bersch, B; Koehl, P; Milon, A; Nakatani, Y; Ourisson, G | 1 |
| Humpel, C; Saria, A | 1 |
| Imai, Y; Inoki, R; Takiuchi, S; Tang, FD; Yonehara, N | 1 |
| Funayama, N; Shinkai, M; Takayanagi, I | 1 |
| Kamiya, HO; Matsumoto, T; Nakayama, Y; Saito, R; Takano, Y | 1 |
| Chahl, LA; Johnston, PA | 1 |
| Maggi, CA; Zagorodnyuk, V | 1 |
| Honda, K; Kamiya, H; Matsumoto, T; Mizuta, A; Saito, R; Takano, Y | 1 |
| Farina, C; Foley, JJ; Giardina, GA; Grugni, M; Hay, DW; Medhurst, AD; Raveglia, LF; Rigolio, R; Sarau, HM; Schmidt, DB; Vassallo, M; Vecchietti, V | 1 |
| De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Tramontana, M | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Bornstein, JC; Furness, JB; Johnson, PJ; Yuan, SY | 1 |
| Marchionni, D; Nisato, D; Roccon, A | 1 |
| John, C; Kazem, E; Tanaka, DT | 1 |
| Barnouin, MC; Emonds-Alt, X; Hayar, A; Jung, M; Le Fur, G; Michaud, JC; Mons, G; Soubrié, P; Souilhac, J; Steinberg, R | 1 |
| Ciccocioppo, R; de Caro, G; Massi, M; Polidori, C; Pompei, P | 1 |
| Kameyama, T; Shinkai, N; Ukai, M | 3 |
| Brodbeck, RM; Bu, JY; Karpitskiy, VV; Krause, JE; Mentzer, JN; Schmidt, SK; Staveteig, PT; Tucker, JB | 1 |
| Cellier, E; Couture, R; Fayolle, C; Hipskind, PA; Iyengar, S | 1 |
| Eguchi, T; Hatae, T; Kamiya, H; Krause, JE; Nakayama, Y; Okamura, H; Saito, R; Shigeyoshi, Y; Takano, Y | 1 |
| Costa, C; Cozzolino, A; Esposito, C; Falciani, M; Filippelli, A; Porta, R; Rossi, F | 1 |
| Alonso, R; Carayon, P; Fournier, M; Le Fur, G; Petitpretre, G; Soubrié, P | 1 |
| Hay, DW; Medhurst, AD; Parsons, AA; Roberts, JC | 1 |
| Fox, AJ; Naeem, S; Patel, IA; Urbán, L; Walpole, C | 1 |
| Kawamata, T; Maeda, K; Maeda, S; Nakai, M; Tanaka, C; Yamaguchi, T | 1 |
| Farina, C; Giardina, GA; Grugni, M; Hay, DW; Luttmann, M; Medhurst, AD; Raveglia, LF; Rigolio, R; Sarau, HM; Schmidt, DB; Vecchietti, V | 1 |
| Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ | 1 |
| Brelière, JC; Emonds-Alt, X; Le Fur, G; Vilain, P | 1 |
| Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Parsons, AA | 1 |
| Fisher, L; Pennefather, JN | 1 |
| MacNaughton, W; Moore, B; Vanner, S | 1 |
| Barbot, L; Cellier, E; Couture, R; Regoli, D | 1 |
| Chahl, LA; Yip, J | 1 |
| Ginap, T; Kilbinger, H | 1 |
| Barnhart, DC; Kimball, BC; Mulholland, MW; Sarosi, GA; Zhang, W | 1 |
| Altier, N; Stewart, J | 1 |
| Cody, C; Jones, RS; Maubach, KA | 1 |
| Bordin, G; Brunelleschi, S; Colangelo, D; Viano, I | 1 |
| Robertson, D; Wang, X | 1 |
| Endoh, T; Suzuki, T; Yamada, T | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Ardell, JL; Armour, JA; Hoover, DB; Thompson, GW | 1 |
| Grimson, P; Jordan, RE; McKnight, AT; Smart, D; Suman-Chauhan, N | 1 |
| Bougault, I; Le Fur, G; Marco, N; Mons, G; Soubrié, P; Steinberg, R; Thirion, A | 1 |
| Guo, JZ; Otsuka, M; Yoshioka, K | 1 |
| Cavagnera, S; Farina, C; Foley, JJ; Giardina, GA; Graziani, D; Grugni, M; Hay, DW; Luttmann, M; Medhurst, AD; Raveglia, LF; Rigolio, R; Sarau, HM; Schmidt, DB; Vecchietti, V | 1 |
| Jia, YP; Linden, DR; Seybold, VS | 1 |
| Linden, DR; Seybold, VS | 1 |
| Petersen, M; Schaible, HG; Segond von Banchet, G | 1 |
| Buéno, L; Gebhart, GF; Julia, V; Su, X | 1 |
| Hejna, MJ; Krause, JE; Lee, JM; Lorens, JB; Lorens, SA; Magnuson, DJ; Mileusnic, D | 1 |
| Broccardo, M; Improta, G; Tabacco, A | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Buckner, CK; Meeker, SN; Pedersen, KE; Undem, BJ | 1 |
| Calixto, JB; De Lima, TC; Ribeiro, SJ; Teixeira, RM | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Barbot, L; Couture, R; Toma, N | 1 |
| Angelici, O; Bonanno, G; Carità, F; Clarke, GD; Raiteri, M; Schmid, G; Zaratin, P | 1 |
| Flynn, FW | 3 |
| Geraghty, DP; Mazzone, SB | 2 |
| Barthó, L; Benkó, R; Lázár, Z; Lénárd, L; Maggi, CA; Penke, B; Szolcsányi, J; Tóth, G | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Lagente, V; Naline, E | 1 |
| Crane, LH; Hamlin, GP; Nimmo, AJ; Williams, MJ | 3 |
| Holzer, P; Shahbazian, A | 1 |
| Galligan, JJ; Schneider, DA | 1 |
| Barone, FC; Bush, B; Foley, JJ; Giardina, GA; Griswold, DE; Hay, DW; Legos, JJ; Lundberg, D; Luttmann, MA; Martin, LD; Medhurst, AD; Potts, W; Sandhu, P; Sarau, HM; Schmidt, DB; Webb, EF; Whitmore, RG | 1 |
| Ding, YD; Guo, XE; Ju, G; Shi, J; Su, CJ; Su, LY; Xu, JQ | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Jurzak, M; Langlois, X; Leysen, JE; te Riele , P; Wintmolders, C | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Gibbins, IL; Jobling, P; Messenger, JP | 1 |
| Barahona, MV; Bustamante, S; García-Sacristán, A; Hernández, M; Orensanz, LM | 1 |
| Cassone, MC; Collino, M; Dianzani, C; Fantozzi, R; Ferrara, C; Lombardi, G | 1 |
| Abbott, BM; Aharony, D; Albert, JS; Barthlow, HG; Bernstein, PR; Bialecki, RA; Brown, F; Caccese, R; Ghanekar, S; Lengel, D; McCarthy, M; Ohnmacht, C; Rumsey, WL; Russell, K; Shenvi, A; Undem, B; Wenrich, B | 1 |
| Aggio, A; Carnicelli, V; Ciccocioppo, R; Onori, L; Severi, C; Taddei, G; Tonini, M | 1 |
| Ackley, MA; Asghar, AU; King, AE; Worsley, MA | 1 |
| Manning, BP; Mawe, GM | 1 |
| Jurzak, M; Langlois, X; Leysen, JE; te Riele, P; Wintmolders, C | 1 |
| Burcher, E; Liu, L | 1 |
| Marchetti, C; Nistri, A | 1 |
| Couture, R; Lessard, A | 1 |
| Allouard, N; Bert, L; Bougault, I; Le-Fur, G; Rodier, D; Soubrié, P; Steinberg, R | 1 |
| Barone, FC; Bush, B; Foley, JJ; Giardina, GA; Griswold, DE; Grugni, M; Hay, DW; Kilian, D; Kotzer, CJ; Legos, JJ; Lundberg, D; Luttmann, MA; Martin, LD; Potts, W; Raveglia, LF; Sandhu, P; Sarau, HM; Schmidt, DB; Underwood, DC | 1 |
| Greenwood-Van Meerveld, B; Sutkowski-Markmann, DM; Venkova, K | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Gueudet, C; Le Fur, G; Maffrand, JP; Michaud, JC; Naline, E; Oury-Donat, F; Pascal, M; Poncelet, M; Proietto, V; Soubrié, P; Steinberg, R; Vilain, P | 1 |
| Broccardo, M; Improta, G; Linari, G; Nucerito, V | 1 |
| Anukwu, LU; Canning, BJ; Kajekar, R; Myers, AC; Reynolds, SM | 1 |
| Aghajanian, GK; Ding, Y; Liu, R | 1 |
| Jones, RS; Stacey, AE; Woodhall, GL | 1 |
| Ogier, R; Raggenbass, M | 1 |
| Cvetkovic, V; Fellmann, D; Griffond, B; Poncet, F; Risold, PY | 1 |
| Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Roth, J; Slawecki, CJ | 1 |
| Cunha-Vaz, JG; Gaspar, MN; Macedo, TR; Ribeiro, CA | 1 |
| Bealer, SL; Flynn, FW | 1 |
| Furuta, T; Kaneko, T; Koyano, K; Tomioka, R; Yanagawa, Y | 1 |
| Greenwood-Van Meerveld, B; Venkova, K | 1 |
| Rekling, JC | 1 |
| Bornstein, JC; Johnson, PJ | 1 |
| Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Yamashita, M | 1 |
| Goldie, RG; Hay, DW; Myers, AC | 1 |
| Rance, NE; Sandoval-Guzmán, T | 1 |
| Howe, HE; Sladek, CD; Somponpun, SJ | 1 |
| Couture, R; Deschamps, K | 1 |
| Ikeda, M; Kamikawa, Y; Kojima, S | 1 |
| Bertrand, PP; Bornstein, JC; Monro, RL | 1 |
| DiPette, D; Fink, GD; Galligan, JJ; Katki, K; Miller, SB; Supowit, S | 1 |
| Brouillette, J; Cloutier, F; Couture, R; Deschamps, K; Neugebauer, W; Ongali, B | 1 |
| De Man, JG; De Schepper, HU; De Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC | 1 |
| Barros, M; de Souza Silva, MA; Huston, JP; Jocham, G; Maior, RS; Mello, EL; Müller, CP; Tomaz, C | 1 |
| de Souza Silva, MA; Huston, JP; Jocham, G; Lauber, AC; Müller, CP | 1 |
| Eriksson, EM; Fowler, CJ; Furness, JB; Matsuyama, H; Nguyen, TV; Poole, DP | 1 |
| Adolfsson, R; Ahlstedt, I; de Verdier, J; Drmota, T; Engberg, S; Johansson, A; Jussila, R; Kristensson, E; Leffler, A; Lindström, E; Novén, A; Påhlman, I; Sigfridsson, K; Sundqvist, M; von Mentzer, B | 1 |
| Bian, GL; Chen, LW; Wang, YQ; Wei, LC; Yung, KL | 1 |
| Emala, CW; Gallos, G; Goubaeva, F; Mizuta, F; Mizuta, K; Panettieri, RA; Xu, D; Yang, J; Zhu, D | 1 |
| Amadesi, S; Bunnett, NW; Furness, JB; Poole, DP; Rozengurt, E; Thacker, M | 1 |
| Andren, PE; Chergui, K; Svenningsson, P; Zhang, X | 1 |
| Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T | 1 |
| de Souza Silva, MA; Dere, E; Huston, JP; Zlomuzica, A | 1 |
| Albientz, A; Bohrmann, B; Borroni, E; Glaentzlin, P; Knoflach, F; Messer, J; Nordquist, RE; Ozmen, L; Pauly-Evers, M; Savignac, H; Spooren, W; Walker, G | 1 |
| Medd, AM; Simmons, MA; Sobotka-Briner, CD | 1 |
| Durkin, S; Jacquet, A; Nordquist, RE; Spooren, W | 1 |
| Bassi, GS; Brandão, ML; Broiz, AC; Gomes, MZ | 1 |
| Clerc, N; Copel, C; Crest, M; Delmas, P; Gola, M; Osorio, N | 1 |
| Algeyer, B; Ballard, TM; Nordquist, RE; Ozmen, L; Pauly-Evers, M; Spooren, W | 1 |
| Akcay, T; Atay, Z; Bereket, A; Canan, H; Gribble, FM; Guran, T; Kotan, LD; O'Rahilly, S; Porter, K; Reimann, F; Rocha, N; Semple, RK; Serin, A; Tolhurst, G; Topaloglu, AK; Turan, S | 1 |
| Cluderay, JE; Dada, A; Davies, CH; Dawson, LA; de la Flor, R; Hagan, JJ; Hill, MD; Jones, DN; Jones, GA; Langmead, CJ; Murkitt, GS; Smith, PW; Southam, E; Watson, JM; Wu, Z | 1 |
| Altman, SN; Billings, HJ; Connors, JM; Goodman, RL; Hileman, SM; Holaskova, I; Jacobs, BH; Lehman, MN; McManus, CJ; Nestor, CC | 1 |
| Ali, B; Amin, NA; Ciofi, P; Plant, TM; Ramaswamy, S; Seminara, SB | 1 |
| Dhillo, WS; Jayasena, CN | 1 |
| Couture, R; De Brito Gariepy, H | 1 |
| Corboz, MR; Eckel, SP; Rivelli, MA | 1 |
| Castellano, JM; Clifton, DK; McConkey, SM; Navarro, VM; Pineda, R; Pinilla, L; Ruiz-Pino, F; Steiner, RA; Tena-Sempere, M | 1 |
| Kruse, CG; McCreary, AC; Wadman, WJ; Werkman, TR | 1 |
| Buddenberg, T; de Souza Silva, MA; Huston, JP; Petri, D; Schäble, S; Topic, B | 1 |
| Dacks, PA; Krajewski, SJ; Rance, NE | 1 |
| Blomenröhr, M; García-Galiano, D; Gaytan, F; Krajnc-Franken, MA; Leon, S; Manfredi-Lozano, M; Navarro, VM; Pinilla, L; Romero-Ruiz, A; Tena-Sempere, M; van Ingen Schenau, D; van Noort, PI | 1 |
| Grachev, P; Kinsey-Jones, JS; Li, XF; Lightman, SL; Lin, YS; Milligan, SR; O'Byrne, KT | 1 |
| Barros, M; de Souza Silva, MA; Huston, JP; Schäble, S; Tomaz, C | 1 |
| Briscoe, AM; Davis, SM; Goodman, RL; Hileman, SM; Nestor, CC; Valent, M | 1 |
| Culman, J; Hunt, SP; Tauer, U; Zhao, Y | 1 |
| Bentsen, AH; Ciofi, P; Garcia-Galiano, D; Mikkelsen, JD; Navarro, VM; Pinilla, L; Ruiz-Pino, F; Sanchez-Garrido, MA; Steiner, RA; Tena-Sempere, M | 1 |
| di Domenico, AL; Grachev, P; Kinsey-Jones, JS; Li, XF; Lightman, SL; Millar, RP; O'Byrne, KT | 1 |
| Elsamani, L; Grachev, P; Hu, MH; Li, XF; Lightman, SL; Lin, YS; Millar, RP; O'Byrne, KT; Paterson, SJ | 1 |
| Barros, M; de Souza Silva, MA; Huston, JP; Melamed, JL; Müller, CP; Tomaz, C | 1 |
| Mori, Y; Okamura, H; Sakamoto, K; Wakabayashi, Y; Yamamura, T | 1 |
| Glidewell-Kenney, CA; Grove, AM; Iyer, AK; Meadows, JD; Mellon, PL; Shao, PP | 1 |
| Navarro, VM | 1 |
| Boehm, U; de Croft, S; Herbison, AE | 1 |
| Burger, LL; Moenter, SM; Ruka, KA | 2 |
| Deura, C; Fujii, N; Iwase, A; Kikkawa, F; Maeda, K; Minabe, S; Nakahara, T; Nakamura, S; Noguchi, T; Oishi, S; Tsukamura, H; Uenoyama, Y; Watanabe, Y | 1 |
| Gaskins, GT; Glanowska, KM; Moenter, SM | 1 |
| Grachev, P; Hu, MH; Li, SY; Li, XF; Lightman, SL; Millar, RP; O'Byrne, KT | 1 |
| Chao, OY; de Souza Silva, MA; Nikolaus, S; Wang, AL | 1 |
| Chao, OY; de Souza Silva, MA; Huston, JP; Nikolaus, S | 2 |
| Anzai, N; Kojima, K; Kojima, S; Tohei, A | 1 |
| Goodman, RL; Hardy, SL; Hileman, SM; Lehman, MN; Nestor, CC; Porter, KL | 1 |
| Ballard, TM; Bissantz, C; Bohnert, C; Knoflach, F; Knust, H; Malherbe, P; Marcuz, A; Ratni, H; Spooren, W; Weber, M | 1 |
| Fujii, N; Matsuda, F; Misu, R; Noguchi, T; Ohkura, S; Ohno, H; Oishi, S; Okamura, H; Yamada, A; Yamamoto, K; Yamamura, T | 1 |
| Navarro, VM; Ohkura, S; Okamura, H; Wakabayashi, Y; Yamamura, T | 1 |
| Endo, N; Tanaka, T | 1 |
| Kusaka, M; Matsui, H; Ohkura, S; Okamura, H; Sakamoto, K; Tanaka, T; Wakabayashi, Y; Yamamura, T | 1 |
| Garcia-Galiano, D; Leon, S; Manfredi-Lozano, M; Navarro, VM; Pinilla, L; Roa, J; Ruiz-Pino, F; Sánchez-Garrido, MA; Tena-Sempere, M | 1 |
| Bimpisidis, Z; Caboni, P; Corrias, F; De Luca, MA; Di Chiara, G; Fadda, AM; Lai, F; Maccioni, E | 1 |
| Clarke, IJ; Li, Q; Millar, RP; Smith, JT | 1 |
| Krajewski-Hall, SJ; McMullen, NT; Mittelman-Smith, MA; Rance, NE | 1 |
| Endo, N; Ito, Y; Rahayu, LP; Tanaka, T | 1 |
| Leng, G; Ludwig, M; Millar, RP; Pineda, R; Sabatier, N | 1 |
| De Lima, TC; Duarte, FS; Duzzioni, M; Leme, LR; Smith, Sde P | 1 |
| Connors, JM; Coolen, LM; Goodman, RL; Grachev, P; Hileman, SM; Lehman, MN; McCosh, RB; Porter, KL | 1 |
| Goto, T; Hirabayashi, M; Ieda, N; Ikegami, K; Inoue, N; Maeda, KI; Maturana, AD; Minabe, S; Nakamura, S; Oishi, S; Sanbo, M; Sugimoto, A; Tsukamura, H; Uenoyama, Y | 1 |
| Clifton, DK; Krull, AA; Larsen, SA; Neal-Perry, G; Steiner, RA | 1 |
| Matsuyama, S; Nakamura, S; Ohkura, S; Wakabayashi, Y; Yamamura, T | 1 |
| Garcia, JP; Guerriero, KA; Keen, KL; Kenealy, BP; Seminara, SB; Terasawa, E | 1 |
| Irahara, M; Iwasa, T; Kato, T; Kuwahara, A; Matsui, S; Matsuzaki, T; Mayila, Y; Munkhzaya, M; Tokui, T; Tungalagsuvd, A; Yanagihara, R; Yano, K | 1 |
| Dees, WL; Hiney, JK; Srivastava, VK | 1 |
| Amodei, R; Coolen, LM; Corder, KR; Estill, CT; Gribbin, K; He, W; Jonker, SS; Lehman, MN; Lindgren, I; Roselli, CE; Stormshak, F; Whitler, W | 1 |
| Matsuyama, S; Miwa, M; Morita, Y; Nakamura, S; Ohkura, S; Wakabayashi, Y; Yamamura, T | 1 |
| Aylwin, CF; Carroll, RS; Choi, JH; Fergani, C; Ferrari, K; Kaiser, UB; Leon, S; Lomniczi, A; McCarthy, EA; Naule, L; Navarro, VM; Talbi, R | 1 |
1 review(s) available for senktide and substance p
| Article | Year |
|---|---|
Brain tachykinins and the regulation of salt intake.
Topics: Animals; Appetite; Brain; Cerebral Ventricles; Humans; Peptide Fragments; Sodium, Dietary; Substance P; Tachykinins | 1999 |
1 trial(s) available for senktide and substance p
| Article | Year |
|---|---|
Ovarian and hormonal responses to single or continuous peripheral administration of senktide, a neurokinin 3 receptor agonist, during the follicular phase in goats.
Topics: Animals; Drug Administration Schedule; Female; Goats; Luteinizing Hormone; Ovarian Follicle; Ovary; Peptide Fragments; Receptors, Neurokinin-3; Substance P | 2015 |
280 other study(ies) available for senktide and substance p
| Article | Year |
|---|---|
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Dogs; Humans; Mice; Piperidines; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin | 1997 |
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Fluorescent Dyes; Fura-2; Humans; Lactams; Molecular Conformation; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spectrometry, Fluorescence; Structure-Activity Relationship | 1998 |
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
Topics: Amino Acid Sequence; Animals; Calcium; Cloning, Molecular; Humans; Mice; Molecular Sequence Data; Neurokinin A; Quinolines; Receptors, Neurokinin-3 | 2001 |
Neurokinin3 receptor regulation of acetylcholine release from myenteric plexus.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Enzyme Activation; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Neurokinin B; Peptide Fragments; Protein Kinase C; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P; Tetrodotoxin | 1992 |
Central pressor actions of tachykinin NK-3 receptor in the paraventricular nucleus of the rat hypothalamus.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Injections; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pressoreceptors; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Vasopressins | 1992 |
Conformational analysis of receptor selective tachykinin analogs: senktide and septide.
Topics: Amino Acid Sequence; Circular Dichroism; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Pyrrolidonecarboxylic Acid; Substance P | 1992 |
The motor actions of natural neurokinins and their specific agonists on the gastrointestinal tract of the rat.
Topics: Animals; Charcoal; Gastrointestinal Motility; Injections, Intraperitoneal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Pilot Projects; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins | 1992 |
Characterization of tachykinin-induced ventral root depolarization in the neonatal rat isolated spinal cord.
Topics: Animals; Animals, Newborn; Extracellular Space; In Vitro Techniques; Magnesium Chloride; Neuromuscular Depolarizing Agents; Peptide Fragments; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Tachykinin; Spinal Cord; Spinal Nerve Roots; Substance P; Tachykinins; Tetrodotoxin | 1992 |
The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro.
Topics: Animals; Dopamine; In Vitro Techniques; Male; Neurons; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachykinins | 1992 |
Neurokinin agonists differentially affect A9 and A10 dopamine cells in the rat.
Topics: Animals; Dopamine; Neurokinin A; Neurons; Peptide Fragments; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1992 |
Tachykinins preferentially excite certain complex cells in the infragranular layers of feline striate cortex.
Topics: Animals; Cats; Evoked Potentials, Visual; Female; Iontophoresis; Male; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Substance P; Tachykinins; Visual Cortex | 1992 |
Behavioural consequences following infusion of selective neurokinin agonists into the median raphe nucleus of the rat.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Injections; Molecular Sequence Data; Motor Activity; Neurokinin A; Peptide Fragments; Raphe Nuclei; Rats; Substance P | 1992 |
Identification of the central tachykinin receptor subclass involved in substance P-induced cardiovascular and behavioral responses in conscious rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1992 |
Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide.
Topics: Animals; Autoradiography; Cerebral Cortex; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P | 1990 |
Pharmacological analysis of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum longitudinal muscle-myenteric plexus and cerebral cortex membranes.
Topics: Animals; Cerebral Cortex; Female; Guinea Pigs; Ileum; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Male; Muscle, Smooth; Myenteric Plexus; Nucleotides; Peptide Fragments; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1990 |
Pharmacological characterization of the behavioural syndrome induced by the NK-3 tachykinin agonist senktide in rodents: evidence for mediation by endogenous 5-HT.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mianserin; Peptide Fragments; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Stereotyped Behavior; Substance P | 1990 |
Role of central tachykinin peptides in cardiovascular regulation in rats.
Topics: Adrenal Glands; Angiotensin II; Animals; Blood Pressure; Heart Rate; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Saralasin; Substance P; Sympatholytics; Tachykinins; Vasopressins | 1990 |
Autoradiographic visualization of NK-3 tachykinin binding sites in the rat brain, utilizing [3H]senktide.
Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Brain; Kinetics; Male; Organ Specificity; Paroxetine; Peptide Fragments; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Reference Values; Serotonin Antagonists; Substance P; Tachykinins; Tritium | 1990 |
Characterization of tachykinin receptors in urinary bladder from guinea pig.
Topics: Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder | 1990 |
Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer.
Topics: Animals; Azepines; Cimetidine; Ethanol; Gastric Acid; Gastric Mucosa; Gastrins; Hydroxyzine; In Vitro Techniques; Ketotifen; Leukotriene B4; Male; Mast Cells; Pepsin A; Peptide Fragments; Platelet Activating Factor; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; SRS-A; Substance P; Triazoles | 1991 |
Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat.
Topics: Animals; Injections, Spinal; Male; Methysergide; Morphine; Muscles; Naloxone; Pain; Peptide Fragments; Phentolamine; Phenylephrine; Posture; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Stereotyped Behavior; Substance P | 1990 |
Intra-midbrain raphe injections of the neurokinin-3 agonist senktide inhibit food and water intake in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Male; Mesencephalon; Microinjections; Motor Activity; Muscimol; Peptide Fragments; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.
Topics: Animals; Bronchi; Bronchoconstriction; Cerebral Cortex; Cricetinae; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Neurokinin A; Peptide Fragments; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Urinary Bladder; Vagus Nerve | 1991 |
Injection of tachykinins and selective neurokinin receptor ligands into the substantia nigra reticulata increases striatal dopamine and 5-hydroxytryptamine metabolism.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Peptide Fragments; Rats; Rats, Inbred Strains; Serotonin; Substance P; Substantia Nigra; Tachykinins | 1991 |
Characterization of NK-3 binding sites in rat and guinea pig cortical membranes by the selective ligand [3H]Senktide.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cerebral Cortex; Guinea Pigs; Kinetics; Ligands; Male; Molecular Sequence Data; Neurokinin B; Neuropeptides; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Substance P | 1991 |
Intranigral tachykinin NK3 receptor agonist elicits oral movements in rats.
Topics: Animals; Female; Infusions, Parenteral; Mastication; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachykinins | 1991 |
Neurokinin receptors in the rabbit iris sphincter characterised by novel agonist ligands.
Topics: Animals; In Vitro Techniques; Iris; Kinetics; Ligands; Male; Neurokinin A; Peptide Fragments; Rabbits; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1991 |
Behavioural and biochemical responses following activation of midbrain dopamine pathways by receptor selective neurokinin agonists.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Dopamine; Haloperidol; Limbic System; Male; Mesencephalon; Molecular Sequence Data; Motor Activity; Neural Pathways; Neurokinin A; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Substantia Nigra; Tegmentum Mesencephali | 1991 |
Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.
Topics: Administration, Cutaneous; Amino Acid Sequence; Animals; Bronchoconstriction; Capillary Permeability; Chromatography, High Pressure Liquid; Guinea Pigs; Male; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Trachea | 1991 |
Multiple neurokinin receptor subtypes are present in the colon of the cat and rat.
Topics: Animals; Atropine; Cats; Colon; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1991 |
Evidence for two types of tachykinin receptors on cholinergic neurons of the guinea pig ileum myenteric plexus.
Topics: Acetylcholine; Animals; Choline; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Neurons; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation.
Topics: Animals; Electric Stimulation; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptic Transmission; Vas Deferens | 1991 |
Tachykinin receptor subtype. Central cardiovascular regulation of tachykinin peptides.
Topics: Animals; Blood Pressure; Cerebral Ventricles; Heart Rate; Injections, Intraventricular; Models, Biological; Neuropeptides; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Tachykinins | 1991 |
Evidence for an involvement of eicosanoids in neurokinin3-receptor mediated acetylcholine release from myenteric neurons.
Topics: Acetylcholine; Animals; Arachidonic Acid; Eicosanoids; Guinea Pigs; In Vitro Techniques; Masoprocol; Muscle, Smooth; Myenteric Plexus; Neurons; Peptide Fragments; Phospholipases A; Phospholipases A2; Quinacrine; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Serotonin; Substance P | 1991 |
Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat.
Topics: Acetylcholine; Animals; Animals, Newborn; Calcium; Dihydro-beta-Erythroidine; Edrophonium; Neurokinin A; Neurokinin B; Peptide Fragments; Physostigmine; Potassium; Rats; Rats, Inbred Strains; Secretory Rate; Spinal Cord; Stimulation, Chemical; Substance P; Tetrodotoxin; Veratridine | 1991 |
Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Neurokinin A; Peptide Fragments; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Substance P; Tachykinins | 1991 |
Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Choline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Pyrrolidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Receptors, Tachykinin; Serotonin; Substance P; Tritium | 1991 |
The presence of NK3 tachykinin receptors on rat uterus.
Topics: Animals; Binding, Competitive; Eledoisin; Female; Humans; In Vitro Techniques; Neurokinin A; Peptide Fragments; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Succinimides; Tachykinins; Uterine Contraction; Uterus | 1991 |
Behavioural effects of receptor-specific substance P agonists.
Topics: Animals; Behavior, Animal; Injections, Spinal; Male; Muscle Hypotonia; Pain Measurement; Paralysis; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Nerve Roots; Stereotyped Behavior; Substance P | 1987 |
The NK-3 tachykinin receptor agonist senktide elicits 5-HT-mediated behaviour following central or peripheral administration in mice and rats.
Topics: Animals; Behavior, Animal; Female; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Serotonin; Substance P | 1988 |
The actions of receptor-selective substance P analogs on myenteric neurons: an electrophysiological investigation.
Topics: Action Potentials; Animals; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Neurons; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1988 |
The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation.
Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Haloperidol; Hydroxydopamines; Injections, Subcutaneous; Male; Oxidopamine; Parasympathetic Nervous System; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Scopolamine; Stereotyped Behavior; Substance P; Yawning | 1988 |
Intra-raphe neurokinin-induced hyperactivity: effects of 5,7-dihydroxytryptamine lesions.
Topics: 5,7-Dihydroxytryptamine; Action Potentials; Animals; Catecholamines; Dihydroxytryptamines; Male; Medial Forebrain Bundle; Motor Activity; Neural Pathways; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1989 |
Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Rats, Inbred Strains; Substance P | 1989 |
Conformational behavior of the linear hexapeptide senktide: a receptor specific tachykinin analog.
Topics: Amides; Circular Dichroism; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Peptide Fragments; Protein Conformation; Substance P | 1989 |
Central pressor actions of neurokinin B: increases in neurokinin B contents in discrete nuclei in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Neurokinin B; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Substance P | 1989 |
Characterisation of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum and cerebral cortex.
Topics: Animals; Cerebral Cortex; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; Peptide Fragments; Rats; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1989 |
Effects of neurokinins on ion transport and sulfated macromolecule release in the isolated ferret trachea.
Topics: Amiloride; Animals; Biological Transport; Bumetanide; Chlorides; Electrodes; Ferrets; In Vitro Techniques; Macromolecular Substances; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Sodium; Substance P; Sulfates; Trachea | 1989 |
Substance P enhances the release of endogenous serotonin from rat ventral spinal cord.
Topics: Animals; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Potassium; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Substance P | 1989 |
Signal-transduction pathways causing slow synaptic excitation in guinea pig myenteric AH neurons.
Topics: Animals; Colforsin; Drug Synergism; Electric Conductivity; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Male; Myenteric Plexus; Neurons; Peptide Fragments; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Signal Transduction; Substance P; Synapses; Virulence Factors, Bordetella | 1995 |
Comparison of the effects of (+/-) CP 96,345 and L-668,169 on neurokinin receptor mediated responses in rat and guinea-pig isolated tissues.
Topics: Animals; Biphenyl Compounds; Eledoisin; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Organ Specificity; Peptide Fragments; Peptides, Cyclic; Portal Vein; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Species Specificity; Substance P; Urinary Bladder | 1993 |
Central administration of senktide, a tachykinin NK-3 agonist, has an antidiuretic action by stimulating AVP release in water-loaded rats.
Topics: Animals; Arginine Vasopressin; Benzazepines; Diuresis; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Urodynamics; Water | 1993 |
Selective agonists at NK3 tachykinin receptors inhibit alcohol intake in Sardinian alcohol-preferring rats.
Topics: Alcohol Drinking; Amino Acid Sequence; Animals; Drinking Behavior; Eating; Injections, Intraventricular; Male; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Water Deprivation | 1994 |
A new selective bioassay for tachykinin NK3 receptors based on inositol monophosphate accumulation in the guinea pig ileum.
Topics: Animals; Biphenyl Compounds; Guinea Pigs; Hypnotics and Sedatives; Ileum; In Vitro Techniques; Inositol Phosphates; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Phospholipids; Receptors, Neurokinin-3; Stimulation, Chemical; Substance P; Tachykinins | 1993 |
Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons.
Topics: Acetylcholine; Animals; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Haloperidol; In Vitro Techniques; Male; Neostriatum; Neurons; Oxidopamine; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P; Tachykinins | 1993 |
Involvement of NK1 receptors in synaptic transmission in the guinea pig coeliac ganglion.
Topics: Animals; Electric Stimulation; Evoked Potentials; Female; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Receptors, Neurokinin-1; Substance P; Synapses; Synaptic Transmission; Tachykinins | 1993 |
Effects of ageing on tachykinin function in the basal ganglia.
Topics: Aging; Analysis of Variance; Animals; Basal Ganglia; Grooming; Infusions, Parenteral; Male; Motor Activity; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Stereotyped Behavior; Substance P; Substantia Nigra; Tachykinins; Ventral Tegmental Area | 1993 |
Effects of tachykinins on phosphoinositide metabolism in the hypothalamus: is the NK1 receptor involved?
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Hypothalamus; In Vitro Techniques; Inositol; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
Effect of longitudinal muscle-myenteric plexus removal and indomethacin on the response to tachykinin NK-2 and NK-3 receptor agonists in the circular muscle of the guinea-pig ileum.
Topics: Animals; Atropine; Calcium Channel Blockers; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth; Myenteric Plexus; Neurokinin A; omega-Conotoxin GVIA; Peptide Fragments; Peptides; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tetrodotoxin | 1994 |
Multiple types of tachykinin receptor mediate a slow excitation of rat spinal motoneurones in vitro.
Topics: Animals; Animals, Newborn; Female; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tetrodotoxin | 1994 |
Non-peptide angiotensin receptor antagonists bind to tachykinin NK3 receptors of rat and guinea pig brain.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Brain Chemistry; Drug Evaluation, Preclinical; Guinea Pigs; In Vitro Techniques; Kinetics; Ligands; Membranes; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 1994 |
Localization of striatal and nigral tachykinin receptors in the rat.
Topics: Animals; Autoradiography; Corpus Striatum; Male; Mazindol; Medial Forebrain Bundle; Oxidopamine; Peptide Fragments; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Substantia Nigra; Tissue Distribution | 1994 |
A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus.
Topics: Animals; Atropine; Biphenyl Compounds; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neuromuscular Junction; Peptide Fragments; Peptides, Cyclic; Physalaemin; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Substance P; Tetragastrin; Tetrodotoxin | 1994 |
Typical and atypical NK1 tachykinin receptor characteristics in the rabbit isolated iris sphincter.
Topics: Animals; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phenoxybenzamine; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 1994 |
On the nature of the 5-HT receptor subtype inhibiting acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin B; Peptide Fragments; Receptors, Neurokinin-3; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P | 1994 |
Two NK-3 receptor subtypes: demonstration by biological and binding assays.
Topics: Animals; Brain Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Membranes; Muscle, Smooth; Muscle, Smooth, Vascular; Peptide Fragments; Portal Vein; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P; Tachykinins | 1994 |
Characterisation of [125I][MePhe7]neurokinin B binding to tachykinin NK3 receptors: evidence for interspecies variance.
Topics: Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; Molecular Sequence Data; Neurokinin B; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Tachykinin; Regression Analysis; Substance P | 1994 |
Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors.
Topics: Animals; Benzamides; Calcium; Calcium-Transporting ATPases; CHO Cells; Cricetinae; Cricetulus; Estrenes; Fura-2; Humans; Inositol Phosphates; Manganese; Neurokinin A; Peptide Fragments; Piperidines; Pyrrolidinones; Receptors, Neurokinin-3; Ryanodine; Second Messenger Systems; Structure-Activity Relationship; Substance P; Tachykinins; Terpenes; Thapsigargin; Type C Phospholipases | 1994 |
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin | 1994 |
Contribution of chloride conductance increase to slow EPSC and tachykinin current in guinea-pig myenteric neurones.
Topics: Animals; Chloride Channels; Colforsin; Guinea Pigs; Male; Mefenamic Acid; Myenteric Plexus; Neural Conduction; Niflumic Acid; Peptide Fragments; Substance P; Synaptic Transmission; Tachykinins | 1994 |
Tachykinin receptors involved in the contractile effect of the natural tachykinins in the rat gastric fundus.
Topics: Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Indoles; Isoindoles; Male; Methacholine Chloride; Muscle Contraction; Neurokinin A; Neurokinin B; Peptide Fragments; Peptides, Cyclic; Rats; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
Tachykinin NK3 receptor agonist blocks sodium deficiency-induced shift in taste reactivity.
Topics: Animals; Evaluation Studies as Topic; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sodium; Sodium Chloride; Substance P; Taste | 1994 |
GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Astrocytoma; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Humans; Male; Molecular Sequence Data; Neurokinin B; Oligopeptides; Peptide Fragments; Portal Vein; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transfection; Tumor Cells, Cultured | 1994 |
Pharmacology of tachykinin receptors on neurones in the ventral tegmental area of rat brain slices.
Topics: Action Potentials; Animals; Electrophysiology; In Vitro Techniques; Microelectrodes; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Ventral Tegmental Area | 1995 |
Neurokinin actions on substantia gelatinosa neurones in an adult longitudinal spinal cord preparation.
Topics: Afferent Pathways; Animals; Electric Stimulation; Male; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Substance P; Substantia Gelatinosa; Time Factors | 1995 |
Low responsiveness to agents evoking 5-HT2 receptor-mediated behaviors in Sardinian alcohol-preferring rats.
Topics: 5-Hydroxytryptophan; Alcohol Drinking; Amphetamines; Animals; Behavior, Animal; Carbidopa; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Peptide Fragments; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin Agents; Serotonin Receptor Agonists; Substance P | 1995 |
Subtypes of tachykinin receptors on tonic and phasic neurones in coeliac ganglion of the guinea-pig.
Topics: Animals; Female; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Receptors, Tachykinin; Substance P | 1995 |
Subcutaneous injections of the tachykinin senktide reduce alcohol intake in alcohol-preferring rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Choice Behavior; Drinking Behavior; Feeding Behavior; Injections, Subcutaneous; Male; Motor Activity; Peptide Fragments; Rats; Rats, Inbred Strains; Saccharin; Substance P | 1995 |
Activity of SR 142801 at peripheral tachykinin receptors.
Topics: Analysis of Variance; Animals; Binding, Competitive; Capsaicin; Cricetinae; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Portal Vein; Pulmonary Artery; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 1995 |
Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acids; Male; N-Methylaspartate; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1995 |
Two classes of binding sites for [3H]substance P in rat cerebral cortex.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cerebral Cortex; Female; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Male; Models, Biological; Molecular Sequence Data; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tachykinins | 1993 |
The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea but not in the rat.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptosomes; Tachykinins; Type C Phospholipases | 1993 |
Functional difference between SP and NKA: relaxation of gastric muscle by SP is mediated by VIP and NO.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitric Oxide; Nitroarginine; Peptide Fragments; Stomach; Substance P; Tachykinins; Tetrodotoxin; Vasoactive Intestinal Peptide | 1993 |
Agonists selective for tachykinin NK1 and NK3 receptors excite subpopulations of neurons in the rat medial habenula nucleus in vitro.
Topics: Animals; Electrophysiology; Extracellular Space; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Thalamic Nuclei | 1993 |
Further studies on the effects of selective neurokinin agonists upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intra-Arterial; Injections, Intraventricular; Male; Neurokinin A; Peptide Fragments; Physalaemin; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Reflex; Substance P; Urinary Bladder; Urination | 1993 |
1H nuclear magnetic resonance determination of the membrane-bound conformation of senktide, a highly selective neurokinin B agonist.
Topics: Amino Acid Sequence; Liposomes; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Neurokinin B; Peptide Fragments; Protein Conformation; Solutions; Substance P; Thermodynamics; Water | 1993 |
Nitric oxide is the mediator of tachykinin NK3 receptor-induced relaxation in the circular muscle of the guinea-pig ileum.
Topics: Animals; Arginine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroarginine; omega-Conotoxins; Peptide Fragments; Peptides; Receptors, Neurokinin-3; Substance P; Vasoactive Intestinal Peptide | 1993 |
Characterization of neurokinin binding sites in rat brain membranes using highly selective ligands.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain Chemistry; Eledoisin; Female; Ligands; Membrane Proteins; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins | 1993 |
Involvement of substance P present in small-diameter afferent fibers in microcirculatory hemodynamics of the rat hind instep.
Topics: Afferent Pathways; Animals; Bradykinin; Dose-Response Relationship, Drug; Hindlimb; Male; Microcirculation; Muscle, Smooth, Vascular; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Skin; Substance P | 1993 |
Regional differences in contractile responses to tachykinin agonists and to electrical field stimulation are dependent on distribution of proteinase activity.
Topics: Animals; Bronchi; Electric Stimulation; Endopeptidases; Glycopeptides; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Protease Inhibitors; Rabbits; Substance P; Trachea | 1993 |
The mechanism of central pressor actions of tachykinin NK-3 receptor in the paraventricular nucleus of the hypothalamus in rats.
Topics: Animals; Blood Pressure; Models, Biological; Neurokinin A; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Receptors, Neurokinin-3; Substance P | 1993 |
Neurokinin-1, -2 and -3 receptors are candidates for a role in the opiate withdrawal response in guinea-pigs.
Topics: Animals; Cerebral Ventricles; Guinea Pigs; Injections, Intraventricular; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Substance Withdrawal Syndrome | 1993 |
Neuronal tachykinin NK2 receptors mediate release of non-adrenergic non-cholinergic inhibitory transmitters in the circular muscle of guinea-pig colon.
Topics: Animals; Colon; Guinea Pigs; Male; Membrane Potentials; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
Nitric oxide is a mediator of tachykinin NK3 receptor-induced relaxation in rat mesenteric artery.
Topics: Amino Acid Sequence; Animals; Aorta; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Molecular Sequence Data; Nitric Oxide; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Vasodilation | 1995 |
2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.
Topics: Animals; Binding, Competitive; CHO Cells; Ciliary Body; Cricetinae; Cricetulus; Drug Design; Guinea Pigs; Humans; Muscle Contraction; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Structure-Activity Relationship; Substance P | 1996 |
In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.
Topics: Adrenergic Agents; Animals; Colon; Dose-Response Relationship, Drug; Guanethidine; Hexamethonium; Male; Muscle Contraction; Neurokinin A; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Effect of SR 142801 on nitric oxide-dependent and independent responses to tachykinin NK3 receptor agonists in isolated guinea-pig colon.
Topics: Animals; Arginine; Colon; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P | 1995 |
Analysis of contributions of acetylcholine and tachykinins to neuro-neuronal transmission in motility reflexes in the guinea-pig ileum.
Topics: Acetylcholine; Afferent Pathways; Animals; Efferent Pathways; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Ileum; Male; Membrane Potentials; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Peptide Fragments; Receptors, Neurokinin-3; Reflex; Scopolamine; Substance P; Synaptic Transmission; Tachykinins | 1996 |
Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Injections, Intravenous; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Substance P | 1996 |
Neurokinin subtype receptors mediating substance P contraction in immature rabbit airways.
Topics: Animals; Atropine; Bronchi; Glycopeptides; Isometric Contraction; Muscle, Smooth; Neostigmine; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1996 |
Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin NK3 receptor stimulation.
Topics: Adrenergic Fibers; Animals; Brain; Dose-Response Relationship, Drug; Gerbillinae; Guinea Pigs; Locus Coeruleus; Microdialysis; Neuropeptides; Norepinephrine; Peptide Fragments; Piperidines; Prazosin; Receptors, Neurokinin-3; Substance P | 1996 |
Effects of the selective tachykinin NK3 receptor agonist NH2-senktide on intraoral intake and taste reactivity responses elicited by NaCl in sodium-replete rats.
Topics: Animals; Appetite Regulation; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Sodium; Sodium Chloride; Substance P; Taste | 1996 |
Neurokinin A and senktide attenuate scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Amnesia; Animals; Male; Maze Learning; Mice; Neurokinin A; Peptide Fragments; Psychomotor Performance; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Scopolamine; Substance P | 1996 |
Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
Topics: Animals; Arachidonic Acid; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Neurokinin B; Peptide Fragments; Radioligand Assay; Receptors, Neurokinin-3; Recombinant Proteins; Second Messenger Systems; Sequence Homology; Substance P; Tachykinins | 1997 |
Peripheral effects of three novel non-peptide tachykinin NK1 receptor antagonists in the anaesthetized rat.
Topics: Anesthesia; Animals; Blood Pressure; Carbachol; Dose-Response Relationship, Drug; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Rats; Rats, Wistar; Salivation; Stereoisomerism; Substance P | 1996 |
Antidiuretic action of tachykinin NK-3 receptor in the rat paraventricular nucleus.
Topics: Angiotensin Receptor Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Biphenyl Compounds; Diuresis; Imidazoles; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Neurokinin-3; Receptors, Vasopressin; Solubility; Substance P; Tetrazoles; Urine | 1996 |
Transglutaminase-synthesized spermine derivative of substance P recognizes rat portal vein neurokinin-3 receptors.
Topics: Androstanes; Animals; Benzimidazoles; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Physalaemin; Piperidines; Portal Vein; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Thiorphan; Transglutaminases; Vasoconstriction | 1997 |
Evidence for modulation of dopamine-neuronal function by tachykinin NK3 receptor stimulation in gerbil mesencephalic cell cultures.
Topics: Animals; Calcium; Cells, Cultured; Dopamine; Gerbillinae; Intracellular Membranes; Mesencephalon; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Benzamides; Electric Stimulation; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Phenoxybenzamine; Piperidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1997 |
Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Biphenyl Compounds; Evoked Potentials; In Vitro Techniques; Indoles; Isoindoles; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Spinal Cord; Substance P; Tachykinins | 1996 |
Possible different mechanism between amyloid-beta (25-35)-and substance P-induced chemotaxis of murine microglia.
Topics: Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Microglia; Neurofibrillary Tangles; Neurokinin A; Peptide Fragments; Rats; Rats, Wistar; Substance P | 1997 |
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; CHO Cells; Cricetinae; Humans; Hydrogen Bonding; Molecular Structure; Muscle Contraction; Peptide Fragments; Quinolines; Rabbits; Receptors, Neurokinin-3; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substance P | 1997 |
5-HT2 receptor regulation of acetylcholine release induced by dopaminergic stimulation in rat striatal slices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Benzazepines; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Ergolines; Haloperidol; In Vitro Techniques; Ketanserin; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Potassium; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Substance P | 1997 |
Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.
Topics: Anesthetics; Animals; Benzamides; Blood Pressure; Calcitonin Gene-Related Peptide; Dura Mater; Indoles; Isoindoles; Male; Microscopy, Video; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Vasodilator Agents | 1997 |
Tachykinin-induced contractions of the guinea pig ileum longitudinal smooth muscle: tonic and phasic muscular activities.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Substance P; Tachykinins | 1997 |
In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Topics: Animals; In Vitro Techniques; Iris; Male; Miosis; Muscle Contraction; Muscle, Smooth; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 1997 |
Potencies of agonists acting at tachykinin receptors in the oestrogen-primed rat uterus: effects of peptidase inhibitors.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estradiol; Female; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins; Uterine Contraction; Uterus | 1997 |
Cellular pathways mediating tachykinin-evoked secretomotor responses in guinea pig ileum.
Topics: Animals; Capsaicin; Electric Stimulation; Evoked Potentials; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins | 1997 |
Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat.
Topics: Animals; Behavior, Animal; Cardiovascular System; Dogs; Indoles; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 1997 |
Localization of Fos-like immunoreactivity induced by the NK3 tachykinin receptor agonist, senktide, in the guinea-pig brain.
Topics: Animals; Behavior, Animal; Brain; Female; Guinea Pigs; Male; Neurons; Peptide Fragments; Piperidines; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-3; Substance P; Tyrosine 3-Monooxygenase | 1997 |
NK1- and NK3-receptor mediated inhibition of 5-hydroxytryptamine release from the vascularly perfused small intestine of the guinea-pig.
Topics: Animals; Drug Interactions; Enterochromaffin Cells; Guinea Pigs; Ileum; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-3; Serotonin; Substance P; Tetrodotoxin | 1997 |
Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dipeptides; Fluorometry; Guinea Pigs; Indoles; Lanthanum; Myenteric Plexus; Neurokinin A; Nickel; Nifedipine; Peptide Fragments; Peptides, Cyclic; Receptors, Tachykinin; Substance P; Tachykinins; Virulence Factors, Bordetella | 1998 |
Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions.
Topics: Amphetamine; Analgesics, Non-Narcotic; Animals; Central Nervous System Stimulants; Formaldehyde; Male; Microinjections; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 1997 |
Lateral ventricular injections of the NK3 agonist senktide affect salt taste-elicited responses.
Topics: Animals; Appetite; Avoidance Learning; Conditioning, Psychological; Injections, Intraventricular; Lithium Chloride; Male; Peptide Fragments; Rats; Receptors, Neurokinin-3; Sodium Chloride; Substance P; Taste | 1998 |
Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition.
Topics: Animals; Baclofen; Bicuculline; Entorhinal Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurokinin A; Neurokinin B; Neurons; Peptide Fragments; Phosphinic Acids; Propanolamines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Receptors, GABA-B; Substance P; Synapses; Tachykinins | 1998 |
Tachykinin receptors are present on human monocytes and play a role in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cell Separation; Female; Humans; Male; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Neurokinin B; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Substance P-induced inward current in identified auditory efferent neurons in rat brain stem slices.
Topics: Animals; Auditory Pathways; Brain Stem; Cesium; Chlorides; Cochlea; Efferent Pathways; In Vitro Techniques; Models, Neurological; Neurons; Norepinephrine; Patch-Clamp Techniques; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tetraethylammonium; Tetrodotoxin; Time Factors | 1998 |
Tachykinin-depolarizations mediated by neurokinin-3 receptors in the hamster submandibular ganglion cells.
Topics: Animals; Cricetinae; Electric Impedance; Electrophysiology; Ganglia, Parasympathetic; Ion Channels; Membrane Potentials; Neurokinin B; Patch-Clamp Techniques; Peptide Fragments; Potassium Channels; Receptors, Neurokinin-3; Substance P; Tachykinins | 1998 |
Involvement of dopamine receptors in beneficial effects of tachykinins on scopolamine-induced impairment of alternation performance in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amnesia; Animals; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Male; Memory; Mice; Neurokinin A; Peptide Fragments; Phenethylamines; Receptors, Cholinergic; Receptors, Dopamine D1; Receptors, Dopamine D2; Scopolamine; Substance P; Sulpiride; Tachykinins | 1998 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors.
Topics: Animals; Dogs; Heart; Myocardial Contraction; Neurokinin A; Neurons, Afferent; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1998 |
Ameliorative effects of tachykinins on scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Animals; Male; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Peptide Fragments; Psychomotor Performance; Scopolamine; Substance P; Tachykinins | 1998 |
Activation of the cloned human NK3 receptor in Chinese Hamster Ovary cells characterized by the cellular acidification response using the Cytosensor microphysiometer.
Topics: Animals; Biochemistry; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Evaluation Studies as Topic; Female; Humans; Hydrogen-Ion Concentration; Peptide Fragments; Radioligand Assay; Receptors, Cholecystokinin; Receptors, Neurokinin-3; Signal Transduction; Substance P; Thapsigargin | 1998 |
Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig.
Topics: Acetylcholine; Animals; Brain; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Male; Microdialysis; Nucleus Accumbens; Peptide Fragments; Piperidines; Prefrontal Cortex; Receptors, Neurokinin-3; Substance P; Substantia Nigra; Synaptic Transmission; Time Factors; Ventral Tegmental Area | 1998 |
Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Neurokinin B; Neurons, Afferent; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Spinal Cord; Spinal Nerve Roots; Substance P | 1998 |
Rat gastrointestinal motor responses mediated via activation of neurokinin receptors.
Topics: Animals; Chromates; Chromium Radioisotopes; Gastric Emptying; Gastrointestinal Motility; Intubation, Gastrointestinal; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sodium Compounds; Substance P | 1999 |
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).
Topics: Animals; Calcium; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Humans; In Vitro Techniques; Iris; Mice; Miosis; Motor Activity; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Quinolines; Rabbits; Radioligand Assay; Receptors, Neurokinin-3; Structure-Activity Relationship; Substance P | 1999 |
Spinal neurokin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Motor Neurons; Movement; Nitric Oxide; Nociceptors; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Reflex; Spinal Cord; Substance P | 1999 |
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
Topics: Animals; Animals, Newborn; Body Temperature; Electric Stimulation; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Male; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Physical Stimulation; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spinal Cord; Substance P | 1999 |
Expression of neurokinin-1 receptors on cultured dorsal root ganglion neurons from the adult rat.
Topics: Animals; Cells, Cultured; Ganglia, Spinal; Kinetics; Male; Neurokinin A; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 1999 |
Role of neurokinin 3 receptors on responses to colorectal distention in the rat: electrophysiological and behavioral studies.
Topics: Animals; Colon; Electromyography; Gastrointestinal Motility; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscle Contraction; Pain Measurement; Peptide Fragments; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-3; Rectum; Sensory Thresholds; Substance P; Visceral Afferents | 1999 |
Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study.
Topics: Amino Acid Sequence; Animals; Autoradiography; Brain; Consensus Sequence; Humans; Immunoglobulin G; Immunohistochemistry; Male; Molecular Sequence Data; Nerve Fibers; Neurons; Organ Specificity; Peptide Fragments; Rats; Receptors, Neurokinin-3; Spinal Cord; Substance P | 1999 |
Central tachykinin NK3 receptors in the inhibitory action on the rat colonic propulsion of a new tachykinin, PG-KII.
Topics: Animals; Colon; Gastrointestinal Transit; Injections, Intraventricular; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Pharmacological examination of the neurokinin-1 receptor mediating relaxation of human intralobar pulmonary artery.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Epoprostenol; Female; Humans; In Vitro Techniques; Lung; Male; Middle Aged; Neurokinin A; Nitric Oxide; Peptide Fragments; Phenylephrine; Pulmonary Artery; Receptors, Neurokinin-1; Receptors, Tachykinin; Substance P; Vasoconstriction; Vasodilation | 2000 |
Tachykinin NK(3)receptor involvement in anxiety.
Topics: Animals; Anxiety; Cerebral Ventricles; Injections, Intraventricular; Male; Maze Learning; Mice; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
SR142801 behaves as a tachykinin NK-3 receptor agonist on a spinal nociceptive reflex in the rat.
Topics: Analgesics; Animals; Drug Interactions; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Intraventricular injections of tachykinin NK3 receptor agonists affect salt intake. A shift in taste intensity?
Topics: Animals; Appetite; Avoidance Learning; Cerebral Ventricles; Dietary Sucrose; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Sodium, Dietary; Substance P; Taste | 1999 |
Respiratory actions of tachykinins in the nucleus of the solitary tract: effect of neonatal capsaicin pretreatment.
Topics: Animals; Animals, Newborn; Capsaicin; Male; Microinjections; Neurokinin A; Neurokinin B; Peptide Fragments; Rats; Rats, Wistar; Respiratory Mechanics; Solitary Nucleus; Substance P; Tachykinins | 2000 |
Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Physalaemin; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridoxal Phosphate; Receptors, Neurokinin-3; Sincalide; Substance P; Vasoactive Intestinal Peptide | 2000 |
NK-3 receptors are expressed on mouse striatal gamma-aminobutyric acid-ergic interneurones and evoke [(3)H] gamma-aminobutyric acid release.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; In Situ Hybridization; Interneurons; Mice; Mice, Inbred C57BL; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Piperidines; Protein Precursors; Receptors, Neurokinin-3; RNA, Messenger; Somatostatin; Substance P; Tachykinins | 2000 |
Neurokinin B- and specific tachykinin NK(3) receptor agonists-induced airway hyperresponsiveness in the guinea-pig.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstrictor Agents; Female; Guinea Pigs; Male; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins; Vasodilator Agents | 2000 |
Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists.
Topics: Animals; Diestrus; Estrogens; Estrus; Female; Metestrus; Neurokinin A; Ovariectomy; Peptide Fragments; Piperidines; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Uterine Contraction | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Presynaptic nicotinic acetylcholine receptors in the myenteric plexus of guinea pig intestine.
Topics: Alkaloids; Animals; Azocines; Calcium; Electric Stimulation; Excitatory Postsynaptic Potentials; Guinea Pigs; Intestines; Magnesium; Male; Microinjections; Myenteric Plexus; Nicotine; Nicotinic Agonists; Peptide Fragments; Presynaptic Terminals; Quinolizines; Receptors, Neurokinin-3; Receptors, Nicotinic; Substance P; Tetrodotoxin | 2000 |
Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
Topics: Animals; Brain; Calcium; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Iris; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Quinolines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P | 2000 |
Distribution of Fos-like immunoreactivity within the rat brain following intraventricular injection of the selective NK(3) receptor agonist senktide.
Topics: Animals; Brain; Image Processing, Computer-Assisted; Immunohistochemistry; Injections, Intraventricular; Male; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Receptors, Neurokinin-3; Substance P; Tissue Distribution | 2000 |
Intracerebroventricular injection of senktide-induced Fos expression in vasopressin-containing hypothalamic neurons in the rat.
Topics: Animals; Hypothalamus; Male; Neurons; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Substance P; Vasopressins | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Gerbillinae; Guinea Pigs; Male; Membranes; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-3; Species Specificity; Substance P | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons.
Topics: Action Potentials; Animals; Biotin; Coloring Agents; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Guinea Pigs; Image Processing, Computer-Assisted; Immune Sera; Male; Microelectrodes; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Protein Kinase C; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Sympathetic Fibers, Postganglionic; Tachykinins | 2001 |
NK2 tachykinin receptors mediate contraction of the pig intravesical ureter: tachykinin-induced enhancement of non-adrenergic non-cholinergic excitatory neurotransmission.
Topics: Animals; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Tonus; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-2; Substance P; Swine; Synaptic Transmission; Ureter | 2001 |
Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.
Topics: Adult; Biphenyl Compounds; Calcium; Calcium Channels; Calcium Signaling; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Humans; Interleukin-8; Ion Transport; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Substance P | 2001 |
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
Topics: Administration, Oral; Animals; Bronchoconstriction; Cricetinae; Guinea Pigs; Humans; Ileum; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Sulfoxides | 2001 |
Contribution of NK3 tachykinin receptors to propulsion in the rabbit isolated distal colon.
Topics: Animals; Colon; Complement C6; Dose-Response Relationship, Drug; Gastrointestinal Motility; In Vitro Techniques; Male; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 2001 |
Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist.
Topics: Action Potentials; Animals; Carrageenan; Hyperalgesia; Inflammation; Lysine; Neurokinin B; Nociceptors; Pain; Peptide Fragments; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 2001 |
Tachykinins mediate slow excitatory postsynaptic transmission in guinea pig sphincter of Oddi ganglia.
Topics: Animals; Calcium; Capsaicin; Culture Techniques; Excitatory Postsynaptic Potentials; Female; Ganglia; Guinea Pigs; Male; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Sphincter of Oddi; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 2001 |
Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists.
Topics: Animals; Autoradiography; Beta Particles; Brain; Central Nervous System; Dose-Response Relationship, Drug; Gerbillinae; Male; Peptide Fragments; Piperidines; Radionuclide Imaging; Receptors, Neurokinin-3; Substance P | 2001 |
Radioligand binding and functional characterisation of tachykinin receptors in chicken small intestine.
Topics: Animals; Binding, Competitive; Chickens; Female; In Vitro Techniques; Intestine, Small; Neurokinin A; Peptide Fragments; Radioligand Assay; Radiopharmaceuticals; Receptors, Tachykinin; Substance P; Succinimides | 2001 |
Neuronal bursting induced by NK3 receptor activation in the neonatal rat spinal cord in vitro.
Topics: Animals; Animals, Newborn; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Locomotion; Membrane Potentials; Motor Neurons; Neurokinin B; Neurons; Patch-Clamp Techniques; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Spinal Cord; Substance P; Tachyphylaxis | 2001 |
Modulation of cardiac activity by tachykinins in the rat substantia nigra.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Atropine; Benzamides; Blood Pressure; Hemodynamics; Indoles; Isoindoles; Male; Microinjections; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachycardia; Tachykinins | 2001 |
Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiemetics; Dose-Response Relationship, Drug; Guinea Pigs; Locus Coeruleus; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Peptide Fragments; Piperidines; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tetrazoles | 2002 |
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central Nervous System; Citric Acid; Cloning, Molecular; Cough; Guinea Pigs; In Vitro Techniques; Iris; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pupil; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin; Recombinant Proteins; Substance P | 2002 |
Peripheral activity of a new NK1 receptor antagonist TAK-637 in the gastrointestinal tract.
Topics: Animals; Capsaicin; Digestive System; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Naphthyridines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Substance P | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist.
Topics: Animals; CHO Cells; Cricetinae; Gerbillinae; Guinea Pigs; Humans; Methylurea Compounds; Motor Activity; Neurokinin B; Peptide Fragments; Piperidines; Rabbits; Rats; Receptors, Neurokinin-3; Substance P | 2002 |
Selective tachykinin NK3-receptor agonists stimulate in vitro exocrine pancreatic secretion in the guinea pig.
Topics: Amylases; Animals; Atropine; Carbachol; Ceruletide; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Pancreas; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-3; Substance P; Substrate Specificity; Tachykinins | 2002 |
Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia.
Topics: Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Trachea; Vagotomy; Vagus Nerve | 2002 |
Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Antibody Technique; Glutamic Acid; In Vitro Techniques; Male; Neurons; Peptide Fragments; Phenylephrine; Raphe Nuclei; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Serotonin; Substance P; Tachykinins; Tetrodotoxin | 2002 |
Estrogen-dependent regulation of neurokinin 3 receptor-mediated uterine contractility in the rat.
Topics: Acetylcholine; Animals; Capsaicin; Dose-Response Relationship, Drug; Estrogens; Estrus; Female; In Vitro Techniques; Ovariectomy; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Uterine Contraction; Uterus | 2002 |
Neurokinin-receptor-mediated depolarization of cortical neurons elicits an increase in glutamate release at excitatory synapses.
Topics: Action Potentials; Animals; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Interneurons; Male; Neurokinin A; Neurokinin B; Patch-Clamp Techniques; Peptide Fragments; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Synapses; Tetrodotoxin | 2002 |
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2003 |
Diencephalic neurons producing melanin-concentrating hormone are influenced by local and multiple extra-hypothalamic tachykininergic projections through the neurokinin 3 receptor.
Topics: Animals; Brain; Colchicine; Feeding Behavior; Hypothalamic Hormones; Hypothalamus; Interneurons; Male; Melanins; Neural Pathways; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Organ Culture Techniques; Peptide Fragments; Piperidines; Pituitary Hormones; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Sexual Behavior; Substance P; Tachykinins | 2003 |
Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration.
Topics: Animals; Animals, Newborn; Autoradiography; Brain Stem; Capsaicin; Indicators and Reagents; Iodine Radioisotopes; Neurokinin A; Peptide Fragments; Rats; Receptors, Tachykinin; Substance P; Succinimides | 2003 |
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles | 2003 |
Neurokinin type-3 receptor stimulation impairs ethanol-associated appetitive behavior in Wistar rats.
Topics: Animals; Appetitive Behavior; Dose-Response Relationship, Drug; Ethanol; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Self Administration; Substance P | 2003 |
Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits.
Topics: Animals; Arterioles; Blood-Retinal Barrier; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Male; Microinjections; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neuropeptides; Optic Nerve; Peptide Fragments; Rabbits; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Retinal Vessels; Substance P; Sumatriptan; Vasodilation | 2004 |
Central neurokinin 3 receptors increase systemic oxytocin release: interaction with norepinephrine.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Ventricles; Female; Injections, Intraventricular; Microdialysis; Norepinephrine; Oxytocin; Peptide Fragments; Phentolamine; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P | 2003 |
Circular versus longitudinal myometrial contractile response to selective tachykinin receptor agonists in rat.
Topics: Animals; Female; Myometrium; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Uterine Contraction; Uterus | 2003 |
GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex.
Topics: Animals; Animals, Newborn; Axons; Calbindin 2; Calbindins; Cell Count; Cerebral Cortex; Cholera Toxin; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunoenzyme Techniques; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Isoenzymes; Male; Membrane Potentials; Neurons; Neuropeptide Y; Parvalbumins; Patch-Clamp Techniques; Peptide Fragments; Polypyrimidine Tract-Binding Protein; Prosencephalon; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-3; S100 Calcium Binding Protein G; Somatostatin; Substance P; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2004 |
Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion.
Topics: Animals; Capsaicin; Colforsin; Colon; Electric Stimulation; Electrophysiology; Guinea Pigs; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Naphthyridines; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Receptors, Neurokinin-1; Statistics, Nonparametric; Substance P; Tetrodotoxin | 2004 |
NK-3 receptor activation depolarizes and induces an after-depolarization in pyramidal neurons in gerbil cingulate cortex.
Topics: Animals; Cerebral Cortex; Excitatory Postsynaptic Potentials; Female; Gerbillinae; Gyrus Cinguli; Male; Peptide Fragments; Pyramidal Cells; Receptors, Neurokinin-3; Substance P | 2004 |
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial Ganglia neurons.
Topics: Acetates; Adult; Bronchi; Capsaicin; Electric Stimulation; Evoked Potentials; Female; Ganglia, Parasympathetic; Humans; Male; Microscopy, Confocal; Middle Aged; Nerve Fibers; Neurons, Afferent; Peptide Fragments; Quinolines; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 2005 |
Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus.
Topics: Animals; Drug Interactions; Estrogens; Female; Gene Expression Regulation; Hypothalamus; Immunohistochemistry; Injections, Intraventricular; Luteinizing Hormone; Neuropeptide Y; Oncogene Proteins v-fos; Ovariectomy; Peptide Fragments; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P; Time Factors | 2004 |
Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.
Topics: Acetates; Animals; Catecholamines; Cell Compartmentation; Cell Nucleus; Cytoplasm; Endosomes; Hydralazine; Hypotension; Hypothalamo-Hypophyseal System; Hypothalamus, Anterior; Male; Microinjections; Microscopy, Confocal; Neurons; Oxytocin; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Transcription, Genetic; Tryptophan; Vasopressins | 2004 |
Intraventricular injections of tachykinin NK3 receptor agonist reduce the gain of the baroreflex in unrestrained rats.
Topics: Animals; Baroreflex; Blood Pressure; Heart Rate; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Brattleboro; Rats, Long-Evans; Receptors, Neurokinin-3; Restraint, Physical; Species Specificity; Substance P | 2005 |
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2005 |
Loperamide inhibits tachykinin NK3-receptor-triggered serotonin release without affecting NK2-receptor-triggered serotonin release from guinea pig colonic mucosa.
Topics: Animals; Antidiarrheals; Colon; Guinea Pigs; Intestinal Mucosa; Loperamide; Male; Peptide Fragments; Receptors, Tachykinin; Serotonin; Substance P | 2005 |
Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970.
Topics: Animals; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Granisetron; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurons; Peptide Fragments; Phenols; Piperidines; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Sulfonamides | 2005 |
Intraventricular injections of tachykinin NK3 receptor agonists suppress the intake of "salty" tastes by sodium deficient rats.
Topics: Animals; Behavior, Animal; Drinking Behavior; Eating; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Wistar; Reaction Time; Receptors, Neurokinin-3; Saline Solution, Hypertonic; Sodium; Sodium Acetate; Sodium Bicarbonate; Sodium Glutamate; Substance P; Taste; Time Factors; Water-Electrolyte Balance | 2006 |
Increased substance P content in nerve fibers associated with mesenteric veins from deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Topics: Animals; Body Weight; Calcitonin Gene-Related Peptide; Desoxycorticosterone; Dose-Response Relationship, Drug; Hypertension; Immunohistochemistry; Male; Mesenteric Arteries; Mesenteric Veins; Nerve Fibers; Neurons, Afferent; Neurotransmitter Agents; Peptide Fragments; Placebos; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P | 2006 |
Upregulation of tachykinin NK-1 and NK-3 receptor binding sites in the spinal cord of spontaneously hypertensive rat: impact on the autonomic control of blood pressure.
Topics: Acetates; Animals; Autonomic Nervous System; Autoradiography; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Indoles; Injections, Spinal; Male; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Spinal Cord; Substance P; Thoracic Vertebrae; Up-Regulation | 2006 |
The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ilium; In Vitro Techniques; Male; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nitroarginine; Peptide Fragments; Potassium Chloride; Pyrrolidonecarboxylic Acid; Substance P; Tachykinins; Tetrodotoxin | 2006 |
Interaction of the tachykinin NK3 receptor agonist senktide with behavioral effects of cocaine in marmosets (Callithrix penicillata).
Topics: Animals; Behavior, Animal; Callithrix; Cocaine; Drug Interactions; Female; Male; Maze Learning; Motor Activity; Peptide Fragments; Rats; Receptors, Neurokinin-3; Substance P; Tachykinins | 2006 |
Neurokinin 3 receptor activation potentiates the psychomotor and nucleus accumbens dopamine response to cocaine, but not its place conditioning effects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Dopamine; Dopamine Uptake Inhibitors; Locomotion; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Peptide Fragments; Random Allocation; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 2007 |
Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons.
Topics: Action Potentials; Animals; Blotting, Western; Calbindin 2; Cell Membrane; Cytoplasm; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guinea Pigs; Ileitis; Ileum; In Vitro Techniques; Inflammation Mediators; Kinetics; Neuropeptide Y; Oligopeptides; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C-epsilon; Protein Transport; Receptor, PAR-2; Receptors, Neurokinin-3; S100 Calcium Binding Protein G; Signal Transduction; Submucous Plexus; Substance P; Trinitrobenzenesulfonic Acid; Trypsin; Vasoactive Intestinal Peptide | 2007 |
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Foot; Gerbillinae; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2007 |
Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates kainic acid-inducing degeneration of neurons in the substantia nigra of mice.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Drug Synergism; Fluoresceins; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Neurons; Organic Chemicals; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinolines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Substantia Nigra; Tetrazolium Salts; Thiazoles | 2008 |
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.
Topics: Boron Compounds; Calcium Signaling; Humans; Imidazoles; Inositol 1,4,5-Trisphosphate; Muscle, Smooth; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; RNA, Messenger; Substance P; Trachea | 2008 |
Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.
Topics: Acetates; Animals; Cell Line; Diterpenes; Female; Guinea Pigs; Humans; Ileum; Kinetics; Male; Myenteric Plexus; Neurons, Afferent; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase D2; Protein Kinases; Protein Transport; Quinolines; Receptors, G-Protein-Coupled; Receptors, Neurokinin-3; Substance P; Transfection | 2008 |
Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Disease Models, Animal; Dopamine; Feedback; Functional Laterality; Gene Expression Regulation; Levodopa; Oxidopamine; Parkinson Disease; Peptide Fragments; Quinolines; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Serine; Substance P; Sympatholytics; Tyrosine 3-Monooxygenase | 2008 |
Neurokinin receptor modulation of respiratory activity in the rabbit.
Topics: Animals; Exhalation; Inhalation; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phrenic Nerve; Piperidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Vagotomy | 2008 |
NK(3) receptor agonism promotes episodic-like memory in mice.
Topics: Animals; Brain; Cues; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Maze Learning; Mental Recall; Mice; Mice, Inbred C57BL; Orientation; Pattern Recognition, Visual; Peptide Fragments; Receptors, Neurokinin-3; Retention, Psychology; Social Environment; Substance P | 2008 |
Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice.
Topics: Amphetamine; Animals; Behavior, Animal; Brain; Dopamine; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Peptide Fragments; Postural Balance; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Neurokinin-3; Signal Transduction; Substance P; Tyrosine 3-Monooxygenase | 2008 |
Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.
Topics: Animals; Autoradiography; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Guinea Pigs; In Vitro Techniques; Iodine Isotopes; Male; Membrane Potentials; Neurokinin B; Patch-Clamp Techniques; Peptide Fragments; Prefrontal Cortex; Protein Binding; Pyramidal Cells; Quinolines; Quinoxalines; Receptors, Neurokinin-3; Substance P; Valine | 2008 |
The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.
Topics: Animals; Aprepitant; Behavior, Animal; Dose-Response Relationship, Drug; Gerbillinae; Hyperkinesis; Injections, Intraventricular; Male; Models, Animal; Morpholines; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Pharmaceutical Vehicles; Receptors, Neurokinin-3; Species Specificity; Substance P | 2008 |
Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats.
Topics: Animals; Anxiety; Exploratory Behavior; Fear; Male; Maze Learning; Microinjections; Motor Activity; Pain Measurement; Peptide Fragments; Periaqueductal Gray; Quinolines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Ultrasonics; Vocalization, Animal | 2009 |
Activation of neurokinin 3 receptor increases Na(v)1.9 current in enteric neurons.
Topics: Acetates; Animals; Diglycerides; Duodenum; Enteric Nervous System; Enzyme Activation; Enzyme Activators; Excitatory Postsynaptic Potentials; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Kinetics; Muscle, Smooth; Patch-Clamp Techniques; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quinolines; Receptors, Neurokinin-3; Sensory Receptor Cells; Sodium; Sodium Channel Blockers; Sodium Channels; Substance P; Tetrodotoxin | 2009 |
Pharmacological characterization of senktide-induced tail whips.
Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Behavioral Symptoms; Dopamine Antagonists; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Movement; Neurotransmitter Agents; Peptide Fragments; Receptors, Neurokinin-3; Serotonin Antagonists; Species Specificity; Statistics, Nonparametric; Substance P; Tail | 2010 |
Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.
Topics: Adolescent; Adult; Amenorrhea; Breast; DNA Mutational Analysis; Female; Histidine; Homozygote; Hormones; Humans; Hypogonadism; Leucine; Male; Mutation, Missense; Neurokinin B; Pedigree; Peptide Fragments; Puberty; Receptors, Neurokinin-3; Siblings; Signal Transduction; Substance P | 2009 |
In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.
Topics: Aminoquinolines; Animals; Behavior, Animal; Brain; Cerebral Cortex; Cloning, Molecular; Dopamine; Extracellular Space; Guinea Pigs; Habenula; Haloperidol; Humans; Inositol Phosphates; Male; Microdialysis; Neurokinin B; Neurons; Nucleus Accumbens; Peptide Fragments; Peptides; Quinolines; Rats; Receptors, Tachykinin; Substance P | 2010 |
Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep.
Topics: Anestrus; Animals; Brain; Dopamine; Female; Follicular Phase; Gonadotropin-Releasing Hormone; Injections, Intraventricular; Luteal Phase; Luteinizing Hormone; Models, Biological; Neurokinin B; Neurons; Neurotransmitter Agents; Peptide Fragments; Receptors, Neurokinin-3; Sheep; Substance P | 2010 |
Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Drug Interactions; Gonadotropin-Releasing Hormone; Humans; Immunohistochemistry; Injections, Intravenous; Kisspeptins; Luteinizing Hormone; Macaca mulatta; Male; Microscopy, Confocal; Neurokinin B; Oligopeptides; Orchiectomy; Peptide Fragments; Quinolines; Receptors, G-Protein-Coupled; Receptors, LHRH; Receptors, Neurokinin-3; Substance P | 2010 |
Neurokinin B and kisspeptin: sexual partners or single agents?
Topics: Animals; Arcuate Nucleus of Hypothalamus; Drug Interactions; Gonadotropin-Releasing Hormone; Kisspeptins; Luteinizing Hormone; Macaca mulatta; Male; Neurokinin B; Oligopeptides; Orchiectomy; Peptide Fragments; Quinolines; Receptors, G-Protein-Coupled; Receptors, Neurokinin-3; Substance P | 2010 |
Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats.
Topics: Animals; Benzazepines; Blood Pressure; Dopamine; Haloperidol; Heart Rate; Hypertension; Ibotenic Acid; Indoles; Male; Oligopeptides; Peptide Fragments; Quinolines; Raclopride; Rats; Rats, Inbred SHR; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2010 |
Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung.
Topics: Animals; Bronchoconstriction; Bronchoconstrictor Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Lung; Male; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P | 2010 |
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Estradiol; Estrous Cycle; Feedback, Physiological; Female; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Kisspeptins; Luteinizing Hormone; Neurokinin B; Neurons; Organ Specificity; Peptide Fragments; Prosencephalon; Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-3; RNA, Messenger; Signal Transduction; Substance P | 2011 |
NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig.
Topics: Action Potentials; Animals; Antipsychotic Agents; Dopamine; Dopamine Agonists; Electrophysiology; Guinea Pigs; Male; Mesencephalon; Neurons; Organ Culture Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Species Specificity; Substance P | 2011 |
Neurokinin3-R agonism in aged rats has anxiolytic-, antidepressant-, and promnestic-like effects and stimulates ACh release in frontal cortex, amygdala and hippocampus.
Topics: Acetylcholine; Amygdala; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Cholinergic Agents; Dose-Response Relationship, Drug; Frontal Lobe; Hippocampus; Male; Memory; Microdialysis; Motor Activity; Nootropic Agents; Peptide Fragments; Random Allocation; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Swimming | 2011 |
Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat.
Topics: Animals; Body Temperature; Body Temperature Regulation; Estradiol; Female; Hot Flashes; Neurokinin B; Neurons; Peptide Fragments; Preoptic Area; Proto-Oncogene Proteins c-fos; Rats; Receptors, Neurokinin-3; Substance P | 2011 |
Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice.
Topics: Adamantane; Animals; Dipeptides; Follicle Stimulating Hormone; Galanin-Like Peptide; Glutamic Acid; Gonadotropin-Releasing Hormone; Gonadotropins; Hypogonadism; Kisspeptins; Luteinizing Hormone; Male; Mice; Mice, Knockout; Models, Neurological; Naltrexone; Neurokinin B; Peptide Fragments; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide; Signal Transduction; Substance P; Testosterone | 2012 |
The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Dynorphins; Female; Gonadotropin-Releasing Hormone; Kisspeptins; Luteinizing Hormone; Narcotic Antagonists; Neurokinin B; Ovariectomy; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Neurokinin-3; Receptors, Opioid; Receptors, Opioid, kappa; Signal Transduction; Substance P | 2012 |
The NK3 receptor agonist senktide ameliorates scopolamine-induced deficits in memory for object, place and temporal order.
Topics: Animals; Male; Maze Learning; Memory; Memory Disorders; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Recognition, Psychology; Scopolamine; Substance P | 2012 |
Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Female; Gonadotropin-Releasing Hormone; Immunohistochemistry; Kisspeptins; Luteinizing Hormone; Male; Neurokinin B; Neurons; Oligopeptides; Orchiectomy; Ovariectomy; Peptide Fragments; Receptors, Neurokinin-3; Sexual Maturation; Sheep; Substance P; Time Factors | 2012 |
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
Topics: Animals; Behavior, Animal; Benzamides; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptor Cross-Talk; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Substance P | 2012 |
Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids.
Topics: Androgens; Animals; Arcuate Nucleus of Hypothalamus; Dihydrotestosterone; Estradiol; Estrogens; Female; Luteinizing Hormone; Male; Neurokinin B; Neurons; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Sex Characteristics; Sex Factors; Sexual Maturation; Substance P; Testosterone | 2012 |
Suppression of the GnRH pulse generator by neurokinin B involves a κ-opioid receptor-dependent mechanism.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Estradiol; Estrous Cycle; Gonadotropin-Releasing Hormone; Kisspeptins; Luteinizing Hormone; Neurokinin B; Peptide Fragments; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Substance P | 2012 |
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Bodily Secretions; Female; Kisspeptins; Luteinizing Hormone; Male; Naltrexone; Narcotic Antagonists; Neurokinin B; Peptide Fragments; Radioimmunoassay; Rats; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Tachykinin; Substance P | 2012 |
Sensitization of hypervigilance effects of cocaine can be induced by NK3 receptor activation in marmoset monkeys.
Topics: Animals; Anxiety; Behavior, Animal; Callithrix; Cocaine; Dopamine Uptake Inhibitors; Motor Activity; Peptide Fragments; Receptors, Neurokinin-3; Substance P | 2013 |
Electrophysiological and morphological evidence for synchronized GnRH pulse generator activity among Kisspeptin/neurokinin B/dynorphin A (KNDy) neurons in goats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Axons; Dynorphins; Electrodes; Electrophysiological Phenomena; Female; Gene Expression Regulation, Developmental; Goats; Gonadotropin-Releasing Hormone; Kisspeptins; Male; Neurokinin B; Neurons; Peptide Fragments; Pheromones; Substance P | 2013 |
Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons.
Topics: Animals; Base Pairing; Binding Sites; Cell Line; Chromatin Assembly and Disassembly; Enhancer Elements, Genetic; Gonadotropin-Releasing Hormone; Humans; Mice; Neurokinin B; Neurons; Peptide Fragments; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-fos; Rats; Receptors, Neurokinin-3; Sequence Deletion; Substance P; Time Factors; Transcription Factor AP-1; Transcription, Genetic | 2013 |
Interactions between kisspeptins and neurokinin B.
Topics: Animals; Dynorphins; gamma-Aminobutyric Acid; Glutamic Acid; Gonadal Steroid Hormones; Humans; Kisspeptins; Luteinizing Hormone; Mutation; Neurokinin B; Neurons; Peptide Fragments; Puberty; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Neurokinin-3; Rodentia; Sexual Maturation; Substance P | 2013 |
Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arcuate Nucleus of Hypothalamus; Dynorphins; Green Fluorescent Proteins; Kisspeptins; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurokinin B; Neurons; Oligopeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Receptors, Tachykinin; Substance P | 2013 |
Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Benzeneacetamides; Dynorphins; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kisspeptins; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurokinin B; Neurons; Orchiectomy; Peptide Fragments; Pyrrolidines; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Substance P; Time Factors | 2013 |
Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.
Topics: Animals; Drug Implants; Dynorphins; Female; Luteinizing Hormone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurokinin B; Neurons; Ovary; Peptide Fragments; Puberty, Precocious; Random Allocation; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Sexual Maturation; Signal Transduction; Substance P; Weaning | 2013 |
Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult mice.
Topics: Animals; Female; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Kisspeptins; Male; Median Eminence; Mice; Mice, Knockout; Peptide Fragments; Receptors, Neurokinin-3; Substance P | 2013 |
Neurokinin B signaling in the female rat: a novel link between stress and reproduction.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arcuate Nucleus of Hypothalamus; Corticosterone; Corticotropin-Releasing Hormone; Female; Gonadotropin-Releasing Hormone; Injections, Intraventricular; Lipopolysaccharides; Luteinizing Hormone; Neurokinin B; Neurons; Ovariectomy; Peptide Fragments; Pyrimidines; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-3; Receptors, Vasopressin; Reproduction; Signal Transduction; Stress, Physiological; Substance P | 2014 |
NK₃ receptor agonism reinstates temporal order memory in the hemiparkinsonian rat.
Topics: Animals; Male; Medial Forebrain Bundle; Memory; Movement; Neuropsychological Tests; Nootropic Agents; Oxidopamine; Parkinsonian Disorders; Peptide Fragments; Random Allocation; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Time Perception | 2015 |
The neurokinin-3 receptor agonist senktide facilitates the integration of memories for object, place and temporal order into episodic memory.
Topics: Animals; Memory; Memory, Episodic; Peptide Fragments; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Time Factors | 2014 |
Evidence for tachykinin NK3 receptors-triggered peptide YY release from isolated guinea-pig distal colon.
Topics: Animals; Colon; Guinea Pigs; Male; Muscle, Smooth; Peptide Fragments; Peptide YY; Receptors, Neurokinin-3; Substance P | 2014 |
Neurokinin-3 receptor activation in the retrochiasmatic area is essential for the full pre-ovulatory luteinising hormone surge in ewes.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Female; Hypothalamus; Luteinizing Hormone; Neurons; Ovulation; Peptide Fragments; Preoptic Area; Quinolines; Receptors, Neurokinin-3; Sheep; Substance P | 2014 |
Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Binding Sites; Carbamates; Central Nervous System Agents; Dopaminergic Neurons; Female; Gerbillinae; Guinea Pigs; HEK293 Cells; Humans; Locomotion; Male; Models, Molecular; Molecular Sequence Data; Mutation; Neurotransmitter Agents; Pars Compacta; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tissue Culture Techniques | 2014 |
Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation.
Topics: Animals; Female; Goats; Humans; Hypothalamus; Inhibitory Concentration 50; Neurokinin B; Ovariectomy; Peptide Fragments; Peptide Hydrolases; Peptidomimetics; Protein Stability; Receptors, Neurokinin-3; Serum; Substance P; Swine | 2014 |
Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats.
Topics: Animals; Estradiol; Female; Goats; Gonadotropin-Releasing Hormone; Infusions, Intravenous; Kisspeptins; Ligands; Luteinizing Hormone; Neurokinin A; Peptide Fragments; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Signal Transduction; Substance P; Time Factors | 2015 |
Effects of senktide, a neurokinin 3 receptor agonist, on luteinizing hormone secretion and follicular development in anestrous Shiba goats: a pilot study.
Topics: Anestrus; Animals; Drug Administration Schedule; Estradiol; Estrus; Female; Fertility Agents; Goats; Infusions, Intravenous; Luteinizing Hormone; Ovarian Follicle; Ovulation; Peptide Fragments; Pilot Projects; Receptors, Neurokinin-3; Signal Transduction; Substance P; Time Factors | 2014 |
The effects of chronic subcutaneous administration of an investigational kisspeptin analog, TAK-683, on gonadotropin-releasing hormone pulse generator activity in goats.
Topics: Animals; Biological Clocks; Central Nervous System Agents; Dose-Response Relationship, Drug; Female; Goats; Gonadotropin-Releasing Hormone; Hypodermoclysis; Hypothalamus; Infusion Pumps, Implantable; Kisspeptins; Luteinizing Hormone; Male; Peptide Fragments; Pituitary Gland; Receptors, Neurokinin-3; Substance P; Testosterone | 2014 |
Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
Topics: Aging; Animals; Dynorphins; Enkephalins; Female; Follicle Stimulating Hormone; Hypothalamus; Kisspeptins; Luteinizing Hormone; Male; Neurokinin B; Peptide Fragments; Protein Precursors; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2015 |
Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: preparation and in vivo evaluation.
Topics: Animals; Antibodies, Monoclonal; Brain; Drug Compounding; Lactoferrin; Liposomes; Liver; Male; Microdialysis; Peptide Fragments; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Transferrin; Substance P | 2015 |
Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Dynorphins; Estrogens; Estrous Cycle; Female; Gonadotropin-Releasing Hormone; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Luteinizing Hormone; Models, Animal; Neurokinin B; Neurons; Neurotransmitter Agents; Ovariectomy; Peptide Fragments; Receptors, Neurokinin-3; RNA, Messenger; Sheep; Substance P | 2015 |
Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Temperature Regulation; Estradiol; Estrogens; Female; Hot Flashes; Neurons; Peptide Fragments; Preoptic Area; Rats; Receptors, Neurokinin-3; Skin; Substance P; Vasodilation | 2015 |
Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice.
Topics: Androgens; Animals; Arcuate Nucleus of Hypothalamus; Dihydrotestosterone; Dynorphins; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Gonadotropin-Releasing Hormone; Kisspeptins; Male; Mice; Neurokinin B; Neurons; Orchiectomy; Patch-Clamp Techniques; Peptide Fragments; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Receptors, Steroid; Substance P | 2016 |
A Direct Neurokinin B Projection from the Arcuate Nucleus Regulates Magnocellular Vasopressin Cells of the Supraoptic Nucleus.
Topics: Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Infusions, Intraventricular; Kisspeptins; Male; Mice; Mice, Transgenic; Neuroanatomical Tract-Tracing Techniques; Neurokinin B; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Receptors, Neurokinin-3; Substance P; Supraoptic Nucleus; Vasopressins | 2016 |
Evidence for involvement of NK₃ receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.
Topics: Animals; Anxiety; Male; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 2016 |
Concurrent assessment of memory for object and place: Evidence for different preferential importance of perirhinal cortex and hippocampus and for promnestic effect of a neurokinin-3 R agonist.
Topics: Animals; Hippocampus; Male; Memory; N-Methylaspartate; Peptide Fragments; Perirhinal Cortex; Rats; Rats, Wistar; Receptors, Neurokinin-3; Spatial Behavior; Substance P | 2016 |
Surge-Like Luteinising Hormone Secretion Induced by Retrochiasmatic Area NK3R Activation is Mediated Primarily by Arcuate Kisspeptin Neurones in the Ewe.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Female; Infusions, Intraventricular; Kisspeptins; Luteinizing Hormone; Neurons; Peptide Fragments; Preoptic Area; Receptors, Kisspeptin-1; Receptors, Neurokinin-3; Sheep; Substance P | 2016 |
Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones.
Topics: Animals; Cells, Cultured; Connexins; Dynorphins; Gap Junctions; Glycyrrhetinic Acid; Kisspeptins; Medulla Oblongata; Mefloquine; Mice, Transgenic; Neuroglia; Neurokinin B; Neurons; Peptide Fragments; Substance P | 2017 |
A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Body Temperature; Capsaicin; Disease Models, Animal; Female; Hot Flashes; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Preoptic Area; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-3; Skin Temperature; Substance P | 2017 |
A neurokinin 3 receptor-selective agonist accelerates pulsatile luteinizing hormone secretion in lactating cattle.
Topics: Animals; Cattle; Female; Follicle Stimulating Hormone; Lactation; Luteinizing Hormone; Ovulation; Peptide Fragments; Receptors, Neurokinin-3; Substance P | 2017 |
Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys.
Topics: Animals; Female; Gonadotropin-Releasing Hormone; Kisspeptins; Macaca mulatta; Median Eminence; Neurokinin B; Neurons; Peptide Fragments; Quinolines; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Neurokinin-3; Sexual Maturation; Signal Transduction; Substance P | 2017 |
Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents.
Topics: Animals; Fasting; Luteinizing Hormone; Male; Naltrexone; Narcotic Antagonists; Neurokinin B; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Opioid; Signal Transduction; Substance P | 2018 |
Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat.
Topics: Animals; Dynorphins; Female; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Insulin-Like Growth Factor I; Microinjections; Neurokinin B; Peptide Fragments; Peptides; Rats; Receptor, IGF Type 1; Receptors, Neurokinin-3; Receptors, Opioid; Sexual Maturation; Substance P; Up-Regulation | 2019 |
Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep.
Topics: Animals; Female; Fetus; Gonadotropin-Releasing Hormone; Hypothalamus; Kisspeptins; Luteinizing Hormone; Male; Neurokinin B; Oligopeptides; Peptide Fragments; Pregnancy; Receptors, Kisspeptin-1; Receptors, Neurokinin-3; Sheep; Substance P; Testosterone | 2020 |
Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cattle; Female; Gonadotropin-Releasing Hormone; Heat-Shock Response; Luteinizing Hormone; Neurokinin B; Ovary; Peptide Fragments; Receptors, Neurokinin-3; Signal Transduction; Substance P; Vagina | 2021 |
Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Chromatin; DNA; Estradiol; Female; Fertility; Gene Expression Regulation; Immunoprecipitation; Kisspeptins; Leptin; Luteinizing Hormone; Male; Mice; Mice, Knockout; Neurons; Peptide Fragments; Polymerase Chain Reaction; Sex Factors; Sexual Maturation; Substance P | 2021 |