senktide has been researched along with sb 223412 in 10 studies
| Studies (senktide) | Trials (senktide) | Recent Studies (post-2010) (senktide) | Studies (sb 223412) | Trials (sb 223412) | Recent Studies (post-2010) (sb 223412) |
|---|---|---|---|---|---|
| 292 | 1 | 50 | 49 | 2 | 16 |
| Protein | Taxonomy | senktide (IC50) | sb 223412 (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 5 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 4 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.0084 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brawner, ME; Elshourbagy, NA; Foley, JJ; Giardina, GA; Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Potts, W; Sarau, HM; Schmidt, DB; Webb, EF | 1 |
| Ames, RS; Brawner, ME; Buckley, PT; Elshourbagy, NA; Feild, JA; Foley, JJ; Giardina, GA; Hay, DW; Luttmann, MA; Nuthulaganti, P; Sarau, HM; Schmidt, DB | 1 |
| Batt, F; Blanc, S; Dutheuil, G; El Bousmaqui, M; Fraser, GL; Hoveyda, HR; Korac, J; Lapin, A; Lenoir, F; Noël, S; Roy, MO | 1 |
| Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Parsons, AA | 1 |
| Cavagnera, S; Farina, C; Foley, JJ; Giardina, GA; Graziani, D; Grugni, M; Hay, DW; Luttmann, M; Medhurst, AD; Raveglia, LF; Rigolio, R; Sarau, HM; Schmidt, DB; Vecchietti, V | 1 |
| Angelici, O; Bonanno, G; Carità, F; Clarke, GD; Raiteri, M; Schmid, G; Zaratin, P | 1 |
| Anukwu, LU; Canning, BJ; Kajekar, R; Myers, AC; Reynolds, SM | 1 |
| Goldie, RG; Hay, DW; Myers, AC | 1 |
| Adolfsson, R; Ahlstedt, I; de Verdier, J; Drmota, T; Engberg, S; Johansson, A; Jussila, R; Kristensson, E; Leffler, A; Lindström, E; Novén, A; Påhlman, I; Sigfridsson, K; Sundqvist, M; von Mentzer, B | 1 |
| Corboz, MR; Eckel, SP; Rivelli, MA | 1 |
10 other study(ies) available for senktide and sb 223412
| Article | Year |
|---|---|
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Dogs; Humans; Mice; Piperidines; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin | 1997 |
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
Topics: Amino Acid Sequence; Animals; Calcium; Cloning, Molecular; Humans; Mice; Molecular Sequence Data; Neurokinin A; Quinolines; Receptors, Neurokinin-3 | 2001 |
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Topics: Androgens; Animals; Brain; Caco-2 Cells; Chemistry Techniques, Synthetic; CHO Cells; Cricetulus; Crystallography, X-Ray; Drug Discovery; Endocrine System Diseases; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; High-Throughput Screening Assays; Humans; Ligands; Luteinizing Hormone; Male; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Structure-Activity Relationship | 2015 |
In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Topics: Animals; In Vitro Techniques; Iris; Male; Miosis; Muscle Contraction; Muscle, Smooth; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 1997 |
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).
Topics: Animals; Calcium; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Humans; In Vitro Techniques; Iris; Mice; Miosis; Motor Activity; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Quinolines; Rabbits; Radioligand Assay; Receptors, Neurokinin-3; Structure-Activity Relationship; Substance P | 1999 |
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia.
Topics: Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Trachea; Vagotomy; Vagus Nerve | 2002 |
A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial Ganglia neurons.
Topics: Acetates; Adult; Bronchi; Capsaicin; Electric Stimulation; Evoked Potentials; Female; Ganglia, Parasympathetic; Humans; Male; Microscopy, Confocal; Middle Aged; Nerve Fibers; Neurons, Afferent; Peptide Fragments; Quinolines; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 2005 |
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Foot; Gerbillinae; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2007 |
Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung.
Topics: Animals; Bronchoconstriction; Bronchoconstrictor Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Lung; Male; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P | 2010 |