senktide has been researched along with piperidines in 65 studies
| Studies (senktide) | Trials (senktide) | Recent Studies (post-2010) (senktide) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 292 | 1 | 50 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (44.62) | 18.2507 |
| 2000's | 30 (46.15) | 29.6817 |
| 2010's | 6 (9.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, DR; Stoessl, AJ | 1 |
| Chung, FZ; Grimson, P; Guard, S; Madden, Z; Pinnock, R; Suman-Chauhan, N; Watling, K; Woodruff, G | 1 |
| Chung, FZ; Hill, DR; Madden, Z; Pinnock, RD; Suman-Chauhan, N; Webdale, L; Woodruff, GN | 1 |
| Giuliani, S; Maggi, CA; Zagorodnyuk, V | 1 |
| Barthò, L; Holzer, P; Maggi, CA; Patacchini, R | 1 |
| Beaujouan, JC; Glowinski, J; Petitet, F; Saffroy, M; Torrens, Y | 1 |
| Maggi, CA; Zagorodnyuk, V | 1 |
| Farina, C; Foley, JJ; Giardina, GA; Grugni, M; Hay, DW; Medhurst, AD; Raveglia, LF; Rigolio, R; Sarau, HM; Schmidt, DB; Vassallo, M; Vecchietti, V | 1 |
| De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Tramontana, M | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Marchionni, D; Nisato, D; Roccon, A | 1 |
| Barnouin, MC; Emonds-Alt, X; Hayar, A; Jung, M; Le Fur, G; Michaud, JC; Mons, G; Soubrié, P; Souilhac, J; Steinberg, R | 1 |
| Costa, C; Cozzolino, A; Esposito, C; Falciani, M; Filippelli, A; Porta, R; Rossi, F | 1 |
| Alonso, R; Carayon, P; Fournier, M; Le Fur, G; Petitpretre, G; Soubrié, P | 1 |
| Hay, DW; Medhurst, AD; Parsons, AA; Roberts, JC | 1 |
| Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ | 1 |
| Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Parsons, AA | 1 |
| Fisher, L; Pennefather, JN | 1 |
| MacNaughton, W; Moore, B; Vanner, S | 1 |
| Barbot, L; Cellier, E; Couture, R; Regoli, D | 1 |
| Chahl, LA; Yip, J | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Bougault, I; Le Fur, G; Marco, N; Mons, G; Soubrié, P; Steinberg, R; Thirion, A | 1 |
| Guo, JZ; Otsuka, M; Yoshioka, K | 1 |
| Linden, DR; Seybold, VS | 1 |
| Buéno, L; Gebhart, GF; Julia, V; Su, X | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Calixto, JB; De Lima, TC; Ribeiro, SJ; Teixeira, RM | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Barbot, L; Couture, R; Toma, N | 1 |
| Barthó, L; Benkó, R; Lázár, Z; Lénárd, L; Maggi, CA; Penke, B; Szolcsányi, J; Tóth, G | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Lagente, V; Naline, E | 1 |
| Crane, LH; Hamlin, GP; Nimmo, AJ; Williams, MJ | 1 |
| Holzer, P; Shahbazian, A | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Jurzak, M; Langlois, X; Leysen, JE; te Riele , P; Wintmolders, C | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Gibbins, IL; Jobling, P; Messenger, JP | 1 |
| Abbott, BM; Aharony, D; Albert, JS; Barthlow, HG; Bernstein, PR; Bialecki, RA; Brown, F; Caccese, R; Ghanekar, S; Lengel, D; McCarthy, M; Ohnmacht, C; Rumsey, WL; Russell, K; Shenvi, A; Undem, B; Wenrich, B | 1 |
| Aggio, A; Carnicelli, V; Ciccocioppo, R; Onori, L; Severi, C; Taddei, G; Tonini, M | 1 |
| Manning, BP; Mawe, GM | 1 |
| Jurzak, M; Langlois, X; Leysen, JE; te Riele, P; Wintmolders, C | 1 |
| Couture, R; Lessard, A | 1 |
| Allouard, N; Bert, L; Bougault, I; Le-Fur, G; Rodier, D; Soubrié, P; Steinberg, R | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Gueudet, C; Le Fur, G; Maffrand, JP; Michaud, JC; Naline, E; Oury-Donat, F; Pascal, M; Poncelet, M; Proietto, V; Soubrié, P; Steinberg, R; Vilain, P | 1 |
| Anukwu, LU; Canning, BJ; Kajekar, R; Myers, AC; Reynolds, SM | 1 |
| Ogier, R; Raggenbass, M | 1 |
| Cvetkovic, V; Fellmann, D; Griffond, B; Poncet, F; Risold, PY | 1 |
| Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Bornstein, JC; Johnson, PJ | 1 |
| Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Yamashita, M | 1 |
| Couture, R; Deschamps, K | 1 |
| Bertrand, PP; Bornstein, JC; Monro, RL | 1 |
| Brouillette, J; Cloutier, F; Couture, R; Deschamps, K; Neugebauer, W; Ongali, B | 1 |
| Adolfsson, R; Ahlstedt, I; de Verdier, J; Drmota, T; Engberg, S; Johansson, A; Jussila, R; Kristensson, E; Leffler, A; Lindström, E; Novén, A; Påhlman, I; Sigfridsson, K; Sundqvist, M; von Mentzer, B | 1 |
| Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T | 1 |
| Corboz, MR; Eckel, SP; Rivelli, MA | 1 |
| Kruse, CG; McCreary, AC; Wadman, WJ; Werkman, TR | 1 |
| Culman, J; Hunt, SP; Tauer, U; Zhao, Y | 1 |
| Boehm, U; de Croft, S; Herbison, AE | 1 |
| Ballard, TM; Bissantz, C; Bohnert, C; Knoflach, F; Knust, H; Malherbe, P; Marcuz, A; Ratni, H; Spooren, W; Weber, M | 1 |
| De Lima, TC; Duarte, FS; Duzzioni, M; Leme, LR; Smith, Sde P | 1 |
65 other study(ies) available for senktide and piperidines
| Article | Year |
|---|---|
Autoradiographic visualization of NK-3 tachykinin binding sites in the rat brain, utilizing [3H]senktide.
Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Brain; Kinetics; Male; Organ Specificity; Paroxetine; Peptide Fragments; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Tachykinin; Reference Values; Serotonin Antagonists; Substance P; Tachykinins; Tritium | 1990 |
Characterisation of [125I][MePhe7]neurokinin B binding to tachykinin NK3 receptors: evidence for interspecies variance.
Topics: Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; Molecular Sequence Data; Neurokinin B; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Tachykinin; Regression Analysis; Substance P | 1994 |
Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors.
Topics: Animals; Benzamides; Calcium; Calcium-Transporting ATPases; CHO Cells; Cricetinae; Cricetulus; Estrenes; Fura-2; Humans; Inositol Phosphates; Manganese; Neurokinin A; Peptide Fragments; Piperidines; Pyrrolidinones; Receptors, Neurokinin-3; Ryanodine; Second Messenger Systems; Structure-Activity Relationship; Substance P; Tachykinins; Terpenes; Thapsigargin; Type C Phospholipases | 1994 |
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin | 1994 |
Activity of SR 142801 at peripheral tachykinin receptors.
Topics: Analysis of Variance; Animals; Binding, Competitive; Capsaicin; Cricetinae; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Portal Vein; Pulmonary Artery; Rabbits; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Trachea | 1995 |
The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea but not in the rat.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptosomes; Tachykinins; Type C Phospholipases | 1993 |
Neuronal tachykinin NK2 receptors mediate release of non-adrenergic non-cholinergic inhibitory transmitters in the circular muscle of guinea-pig colon.
Topics: Animals; Colon; Guinea Pigs; Male; Membrane Potentials; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1995 |
2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.
Topics: Animals; Binding, Competitive; CHO Cells; Ciliary Body; Cricetinae; Cricetulus; Drug Design; Guinea Pigs; Humans; Muscle Contraction; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Structure-Activity Relationship; Substance P | 1996 |
In vivo evidence for the involvement of tachykinin NK3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon.
Topics: Adrenergic Agents; Animals; Colon; Dose-Response Relationship, Drug; Guanethidine; Hexamethonium; Male; Muscle Contraction; Neurokinin A; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Effect of SR 142801 on nitric oxide-dependent and independent responses to tachykinin NK3 receptor agonists in isolated guinea-pig colon.
Topics: Animals; Arginine; Colon; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P | 1995 |
Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Injections, Intravenous; Male; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Substance P | 1996 |
Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin NK3 receptor stimulation.
Topics: Adrenergic Fibers; Animals; Brain; Dose-Response Relationship, Drug; Gerbillinae; Guinea Pigs; Locus Coeruleus; Microdialysis; Neuropeptides; Norepinephrine; Peptide Fragments; Piperidines; Prazosin; Receptors, Neurokinin-3; Substance P | 1996 |
Transglutaminase-synthesized spermine derivative of substance P recognizes rat portal vein neurokinin-3 receptors.
Topics: Androstanes; Animals; Benzimidazoles; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Physalaemin; Piperidines; Portal Vein; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Thiorphan; Transglutaminases; Vasoconstriction | 1997 |
Evidence for modulation of dopamine-neuronal function by tachykinin NK3 receptor stimulation in gerbil mesencephalic cell cultures.
Topics: Animals; Calcium; Cells, Cultured; Dopamine; Gerbillinae; Intracellular Membranes; Mesencephalon; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P | 1996 |
Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Benzamides; Electric Stimulation; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Phenoxybenzamine; Piperidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1997 |
Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.
Topics: Anesthetics; Animals; Benzamides; Blood Pressure; Calcitonin Gene-Related Peptide; Dura Mater; Indoles; Isoindoles; Male; Microscopy, Video; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Vasodilator Agents | 1997 |
In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Topics: Animals; In Vitro Techniques; Iris; Male; Miosis; Muscle Contraction; Muscle, Smooth; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 1997 |
Potencies of agonists acting at tachykinin receptors in the oestrogen-primed rat uterus: effects of peptidase inhibitors.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estradiol; Female; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Tachykinins; Uterine Contraction; Uterus | 1997 |
Cellular pathways mediating tachykinin-evoked secretomotor responses in guinea pig ileum.
Topics: Animals; Capsaicin; Electric Stimulation; Evoked Potentials; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mucosa; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins | 1997 |
Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat.
Topics: Animals; Behavior, Animal; Cardiovascular System; Dogs; Indoles; Injections, Intraventricular; Male; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 1997 |
Localization of Fos-like immunoreactivity induced by the NK3 tachykinin receptor agonist, senktide, in the guinea-pig brain.
Topics: Animals; Behavior, Animal; Brain; Female; Guinea Pigs; Male; Neurons; Peptide Fragments; Piperidines; Proto-Oncogene Proteins c-fos; Receptors, Neurokinin-3; Substance P; Tyrosine 3-Monooxygenase | 1997 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig.
Topics: Acetylcholine; Animals; Brain; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Male; Microdialysis; Nucleus Accumbens; Peptide Fragments; Piperidines; Prefrontal Cortex; Receptors, Neurokinin-3; Substance P; Substantia Nigra; Synaptic Transmission; Time Factors; Ventral Tegmental Area | 1998 |
Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Capsaicin; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Neurokinin B; Neurons, Afferent; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Spinal Cord; Spinal Nerve Roots; Substance P | 1998 |
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
Topics: Animals; Animals, Newborn; Body Temperature; Electric Stimulation; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Male; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Physical Stimulation; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spinal Cord; Substance P | 1999 |
Role of neurokinin 3 receptors on responses to colorectal distention in the rat: electrophysiological and behavioral studies.
Topics: Animals; Colon; Electromyography; Gastrointestinal Motility; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscle Contraction; Pain Measurement; Peptide Fragments; Piperidines; Pressure; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-3; Rectum; Sensory Thresholds; Substance P; Visceral Afferents | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Tachykinin NK(3)receptor involvement in anxiety.
Topics: Animals; Anxiety; Cerebral Ventricles; Injections, Intraventricular; Male; Maze Learning; Mice; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
SR142801 behaves as a tachykinin NK-3 receptor agonist on a spinal nociceptive reflex in the rat.
Topics: Analgesics; Animals; Drug Interactions; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Capsaicin; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Physalaemin; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyridoxal Phosphate; Receptors, Neurokinin-3; Sincalide; Substance P; Vasoactive Intestinal Peptide | 2000 |
NK-3 receptors are expressed on mouse striatal gamma-aminobutyric acid-ergic interneurones and evoke [(3)H] gamma-aminobutyric acid release.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; In Situ Hybridization; Interneurons; Mice; Mice, Inbred C57BL; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Piperidines; Protein Precursors; Receptors, Neurokinin-3; RNA, Messenger; Somatostatin; Substance P; Tachykinins | 2000 |
Neurokinin B- and specific tachykinin NK(3) receptor agonists-induced airway hyperresponsiveness in the guinea-pig.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstrictor Agents; Female; Guinea Pigs; Male; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tachykinins; Vasodilator Agents | 2000 |
Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists.
Topics: Animals; Diestrus; Estrogens; Estrus; Female; Metestrus; Neurokinin A; Ovariectomy; Peptide Fragments; Piperidines; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Uterine Contraction | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Gerbillinae; Guinea Pigs; Male; Membranes; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-3; Species Specificity; Substance P | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons.
Topics: Action Potentials; Animals; Biotin; Coloring Agents; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Guinea Pigs; Image Processing, Computer-Assisted; Immune Sera; Male; Microelectrodes; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Protein Kinase C; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Sympathetic Fibers, Postganglionic; Tachykinins | 2001 |
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
Topics: Administration, Oral; Animals; Bronchoconstriction; Cricetinae; Guinea Pigs; Humans; Ileum; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Sulfoxides | 2001 |
Contribution of NK3 tachykinin receptors to propulsion in the rabbit isolated distal colon.
Topics: Animals; Colon; Complement C6; Dose-Response Relationship, Drug; Gastrointestinal Motility; In Vitro Techniques; Male; Peptide Fragments; Piperidines; Quinolines; Rabbits; Receptors, Neurokinin-3; Substance P | 2001 |
Tachykinins mediate slow excitatory postsynaptic transmission in guinea pig sphincter of Oddi ganglia.
Topics: Animals; Calcium; Capsaicin; Culture Techniques; Excitatory Postsynaptic Potentials; Female; Ganglia; Guinea Pigs; Male; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Receptors, Tachykinin; Sphincter of Oddi; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 2001 |
Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists.
Topics: Animals; Autoradiography; Beta Particles; Brain; Central Nervous System; Dose-Response Relationship, Drug; Gerbillinae; Male; Peptide Fragments; Piperidines; Radionuclide Imaging; Receptors, Neurokinin-3; Substance P | 2001 |
Modulation of cardiac activity by tachykinins in the rat substantia nigra.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Atropine; Benzamides; Blood Pressure; Hemodynamics; Indoles; Isoindoles; Male; Microinjections; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachycardia; Tachykinins | 2001 |
Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiemetics; Dose-Response Relationship, Drug; Guinea Pigs; Locus Coeruleus; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Norepinephrine; Peptide Fragments; Piperidines; Prefrontal Cortex; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tetrazoles | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist.
Topics: Animals; CHO Cells; Cricetinae; Gerbillinae; Guinea Pigs; Humans; Methylurea Compounds; Motor Activity; Neurokinin B; Peptide Fragments; Piperidines; Rabbits; Rats; Receptors, Neurokinin-3; Substance P | 2002 |
Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia.
Topics: Animals; Bronchi; Bronchoconstriction; Electric Stimulation; Excitatory Postsynaptic Potentials; Ganglia, Parasympathetic; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Trachea; Vagotomy; Vagus Nerve | 2002 |
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2003 |
Diencephalic neurons producing melanin-concentrating hormone are influenced by local and multiple extra-hypothalamic tachykininergic projections through the neurokinin 3 receptor.
Topics: Animals; Brain; Colchicine; Feeding Behavior; Hypothalamic Hormones; Hypothalamus; Interneurons; Male; Melanins; Neural Pathways; Neurokinin B; Neurokinin-1 Receptor Antagonists; Neurons; Organ Culture Techniques; Peptide Fragments; Piperidines; Pituitary Hormones; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Sexual Behavior; Substance P; Tachykinins | 2003 |
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles | 2003 |
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2005 |
Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970.
Topics: Animals; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Granisetron; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurons; Peptide Fragments; Phenols; Piperidines; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substance P; Sulfonamides | 2005 |
Upregulation of tachykinin NK-1 and NK-3 receptor binding sites in the spinal cord of spontaneously hypertensive rat: impact on the autonomic control of blood pressure.
Topics: Acetates; Animals; Autonomic Nervous System; Autoradiography; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Indoles; Injections, Spinal; Male; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Spinal Cord; Substance P; Thoracic Vertebrae; Up-Regulation | 2006 |
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Foot; Gerbillinae; Injections, Intraventricular; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 2007 |
Neurokinin receptor modulation of respiratory activity in the rabbit.
Topics: Animals; Exhalation; Inhalation; Male; Medulla Oblongata; Microinjections; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phrenic Nerve; Piperidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Vagotomy | 2008 |
Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung.
Topics: Animals; Bronchoconstriction; Bronchoconstrictor Agents; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; Lung; Male; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-3; Substance P | 2010 |
NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig.
Topics: Action Potentials; Animals; Antipsychotic Agents; Dopamine; Dopamine Agonists; Electrophysiology; Guinea Pigs; Male; Mesencephalon; Neurons; Organ Culture Techniques; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-3; Species Specificity; Substance P | 2011 |
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
Topics: Animals; Behavior, Animal; Benzamides; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptor Cross-Talk; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Substance P | 2012 |
Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arcuate Nucleus of Hypothalamus; Dynorphins; Green Fluorescent Proteins; Kisspeptins; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurokinin B; Neurons; Oligopeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Receptors, Tachykinin; Substance P | 2013 |
Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Binding Sites; Carbamates; Central Nervous System Agents; Dopaminergic Neurons; Female; Gerbillinae; Guinea Pigs; HEK293 Cells; Humans; Locomotion; Male; Models, Molecular; Molecular Sequence Data; Mutation; Neurotransmitter Agents; Pars Compacta; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tissue Culture Techniques | 2014 |
Evidence for involvement of NK₃ receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.
Topics: Animals; Anxiety; Male; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P | 2016 |