sematilide has been researched along with procainamide in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (80.56) | 18.2507 |
| 2000's | 6 (16.67) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Honerjäger, P; Schmidt, G | 1 |
| Blackburn, KJ; Burges, RA; Gwilt, M; Higgins, AJ; Milne, AA; Solca, AM | 1 |
| Chi, LG; Driscoll, EM; Lucchesi, BR; Mu, DX | 1 |
| Argentieri, TM; Carroll, MS; Sullivan, ME | 1 |
| Birgersdotter, UM; Hilleman, DE; Mohiuddin, SM; Pavlou, HN; Roden, DM; Wong, W | 1 |
| Dancik, S; Koziol, T; Nisperos, E; Woolf, E | 1 |
| Argentieri, TM; Gomez, RP; Lind, JM; Morgan, TK; Nickisch, K; Phillips, GB; Sullivan, ME; Wohl, RA | 1 |
| Krafte, DS; Volberg, WA | 1 |
| Cui, G; Sager, P; Sen, L; Singh, BN; Uppal, P | 1 |
| Imaizumi, Y; Ishii, Y; Kurihara, A; Muraki, K; Watanabe, M | 3 |
| Ellenbogen, KA; Gottlieb, SS; Ogilby, JD; Ramanathan, KB; Singh, BN; Stambler, BS | 1 |
| Hinderling, PH; Shi, J | 1 |
| Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM | 1 |
| Beatch, G; Goernert, L; Laganière, S | 1 |
| Follmer, C; Godfrey, R; Pruitt, C; Sager, PT; Uppal, P | 1 |
| Adaniya, H; Hiraoka, M; Namiki, T; Sawanobori, T | 1 |
| Antimisiaris, M; Godfrey, R; Nademanee, K; Pacifico, A; Pruitt, C; Sager, PT; Singh, BN | 1 |
| Lee, EW; Lee, KS; Tsai, TD | 1 |
| Hinderling, PH; Koziol, T; Lasser, T; Shi, J | 1 |
| Hashimoto, K; Motomura, S; Yamada, A | 1 |
| Dandekar, KA; Gehr, TW; Hinderling, PH; Ripley, E; Shi, J; Sica, DA | 1 |
| Akie, Y; Eto, K; Hashimoto, K; Xue, YX | 1 |
| Chen, J; Hashimoto, K; Komori, S; Li, B; Tamura, K | 1 |
| Beatch, GN; Davis, DR; Laganière, S; Williams, BA | 1 |
| Katori, R; Sato, R; Takai, H | 1 |
| Kajiwara, H; Kameda, H; Takasaki, A; Takeo, S; Tanonaka, K | 1 |
| Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE | 1 |
| Hashimoto, K; Sugiyama, A | 1 |
| Hashimoto, K; Ishida, Y; Kugiyama, K; Satoh, Y; Sugiyama, A; Yoneyama, M; Yoshida, H | 1 |
| Fellows, LK; Tsuchida, A | 1 |
1 review(s) available for sematilide and procainamide
| Article | Year |
|---|---|
[New anti-arrhythmia agents].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Humans; Phenethylamines; Procainamide; Propanolamines; Sotalol; Sulfonamides; Survival Rate; Tachycardia | 1992 |
6 trial(s) available for sematilide and procainamide
| Article | Year |
|---|---|
Pharmacology of the class III antiarrhythmic agent sematilide in patients with arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Half-Life; Humans; Procainamide; Torsades de Pointes | 1992 |
Effects of amiodarone, sematilide, and sotalol on QT dispersion.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Electrocardiography; Follow-Up Studies; Heart Conduction System; Humans; Male; Middle Aged; Procainamide; Retrospective Studies; Sotalol; Tachycardia, Ventricular; Time Factors | 1994 |
Hemodynamic effects of intravenous sematilide in patients with congestive heart failure: a class III antiarrhythmic agent without cardiodepressant effects.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Depression, Chemical; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Procainamide | 1995 |
The effects of beta-adrenergic stimulation on the frequency-dependent electrophysiologic actions of amiodarone and sematilide in humans.
Topics: Action Potentials; Adrenergic beta-Agonists; Amiodarone; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart; Heart Conduction System; Humans; Isoproterenol; Middle Aged; Procainamide; Prospective Studies; Reaction Time; Refractory Period, Electrophysiological; Tachycardia, Ventricular; Ventricular Function | 1994 |
Kinetics and dynamics of sematilide.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cross-Over Studies; Electrocardiography; Half-Life; Heart Rate; Humans; Infusions, Intravenous; Linear Models; Male; Procainamide | 1995 |
Pharmacokinetics of sematilide in renal failure.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cross-Over Studies; Female; Humans; Infusions, Intravenous; Kidney; Male; Middle Aged; Procainamide; Renal Dialysis; Renal Insufficiency | 1996 |
29 other study(ies) available for sematilide and procainamide
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Electropharmacology of dofetilide, a new class III agent, in anaesthetised dogs.
Topics: Action Potentials; Anesthesia; Animals; Anti-Arrhythmia Agents; Dogs; Heart; Heart Ventricles; Hemodynamics; Phenethylamines; Potassium Channels; Procainamide; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Ventricular Fibrillation | 1992 |
Antiarrhythmic and electrophysiologic actions of CK-3579 and sematilide in a conscious canine model of sudden coronary death.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden; Dogs; Electric Stimulation; Electrocardiography; Heart; Heart Rate; Imidazoles; Male; Procainamide; Propanolamines | 1990 |
Cellular electrophysiological effects of the class III antiarrhythmic agents sematilide and clofilium on rabbit atrial tissues.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Electrophysiology; Female; Heart; In Vitro Techniques; Male; Procainamide; Quaternary Ammonium Compounds; Rabbits; Sinoatrial Node | 1991 |
Determination of sematilide in plasma by high-performance liquid chromatography.
Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Male; Procainamide; Regression Analysis; Reproducibility of Results | 1991 |
Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chemical Phenomena; Chemistry; Dogs; Drug Design; Electrophysiology; Guinea Pigs; In Vitro Techniques; Ouabain; Procainamide; Purkinje Fibers; Structure-Activity Relationship | 1990 |
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function | 1994 |
Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Electrophysiology; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Myocardium; Procainamide; Refractory Period, Electrophysiological; Sotalol | 1995 |
Absolute bioavailability estimated from oral data.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Biological Availability; Humans; Injections, Intravenous; Kidney; Models, Chemical; Pharmacokinetics; Procainamide | 1995 |
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium | 1995 |
High-performance liquid chromatographic assay for sematilide in plasma using solid-phase extraction microcolumn technology.
Topics: Animals; Anti-Arrhythmia Agents; Biological Assay; Chromatography, High Pressure Liquid; Half-Life; Injections, Intravenous; Procainamide; Rabbits; Solvents; Spectrophotometry, Ultraviolet | 1994 |
Rate-dependent effects of sematilide on action potential duration in isolated guinea pig ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Potassium Channels; Procainamide; Time Factors | 1994 |
Antiarrhythmic effects of selective prolongation of refractoriness. Electrophysiologic actions of sematilide HCl in humans.
Topics: Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrocardiography, Ambulatory; Heart Conduction System; Humans; Male; Middle Aged; Procainamide; Prospective Studies; Syncope; Tachycardia, Ventricular; Ventricular Fibrillation | 1993 |
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides | 1993 |
Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Dogs; Female; Heart Rate; Male; Papillary Muscles; Piperidines; Procainamide; Pyridines; Pyrimidinones; Sinoatrial Node | 1996 |
Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Injections, Intravenous; Male; Procainamide; Time Factors | 1996 |
Effects of sematilide, a novel class III antiarrhythmic agent, on delayed rectifier K+ current in guinea pig atrial myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Function; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Myocardium; Patch-Clamp Techniques; Potassium; Procainamide | 1996 |
IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Vessels; Heart Rate; Ischemia; Male; Phenethylamines; Procainamide; Pyrimidinones; Rats; Rats, Sprague-Dawley; Reperfusion; Sulfonamides | 1996 |
Rate-dependent effects of sematilide on ventricular monophasic action potential duration and delayed rectifier K+ current in rabbits.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrocardiography; Heart; Heart Ventricles; Hemodynamics; Male; Patch-Clamp Techniques; Potassium Channels; Procainamide; Rabbits | 1996 |
Sematilide blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Procainamide; Ventricular Function | 1997 |
Effects of sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Cell Separation; Heart; In Vitro Techniques; Ion Channels; Membranes; Myocardium; Patch-Clamp Techniques; Potassium Channels; Procainamide; Rabbits; Refractory Period, Electrophysiological; Sodium Channels | 1997 |
Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cations; Creatine Kinase; Diltiazem; Dose-Response Relationship, Drug; Glyburide; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Nicardipine; Procainamide; Rats; Rats, Wistar; Tetrodotoxin | 1999 |
Sematilide. CK 1752, CK 1752A, ZK 110516.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drugs, Investigational; Humans; Potassium Channel Blockers; Procainamide; Rats | 1999 |
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Male; Methoxamine; Phenethylamines; Piperazines; Procainamide; Quaternary Ammonium Compounds; Rabbits; Sotalol; Sulfonamides | 2000 |
Effects of a typical I(Kr) channel blocker sematilide on the relationship between ventricular repolarization, refractoriness and onset of torsades de pointes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dogs; Ether-A-Go-Go Potassium Channels; Female; Heart Ventricles; In Vitro Techniques; Male; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Procainamide; Torsades de Pointes | 2002 |
Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart Block; Male; Procainamide; Torsades de Pointes | 2002 |
Lesion evidence that two distinct regions within prefrontal cortex are critical for n-back performance in humans.
Topics: Adult; Aged; Brain Injuries; Brain Mapping; Cognition; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory, Short-Term; Middle Aged; Neuropsychological Tests; Prefrontal Cortex; Procainamide | 2009 |