selfotel has been researched along with n-methylaspartate in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (11.11) | 18.7374 |
| 1990's | 72 (80.00) | 18.2507 |
| 2000's | 7 (7.78) | 29.6817 |
| 2010's | 1 (1.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigge, CF; Bobovski, TP; Brahce, LJ; Coughenour, LL; Drummond, JT; Hays, SJ; Johnson, G; Novak, PM; Rice, MJ | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Bonaventure, N; Jardon, B | 1 |
| Faden, AI; Panter, SS | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Matsuda, Y; Nonaka, H; Nozawa, M; Toki, S; Tsukuda, E; Yoshida, M | 1 |
| Arnold, MB; Deeter, JB; Jones, ND; Leander, JD; Lodge, D; Ornstein, PL; Schoepp, DD | 1 |
| French, ED | 1 |
| Ohno, M; Ueki, S; Watanabe, S; Yamamoto, T | 1 |
| Fallert, CJ; Lo, TM; Piser, TM; Thayer, SA | 1 |
| Bättig, K; Berz, S; Welzl, H | 1 |
| Calder, LD; Karler, R | 1 |
| Aizenman, E; Hartnett, KA | 1 |
| Bockaert, J; Desagher, S; Fagni, L; Manzoni, O; Prezeau, L; Sahuquet, A; Sladeczek, F | 1 |
| Aizenman, E; Reynolds, IJ | 1 |
| Heikkila, RE; Riordan, DE; Sonsalla, PK | 1 |
| Rosenberg, PA | 1 |
| Millan, MJ | 1 |
| Gjedde, A; Hakim, AM; Hogan, MJ | 1 |
| Arnold, MB; Elzey, T; Leander, JD; Lodge, D; Ornstein, PL; Paschal, JW; Schoepp, DD | 1 |
| Hakim, AM; Hogan, M; Takizawa, S | 1 |
| Abreu, M; Ferkany, J; French, ED; Levenson, S | 1 |
| Mansbach, RS | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Leander, JD; Lodge, D; Ornstein, PL; Salhoff, CR; Schoepp, DD; Zeman, S; Zimmerman, DM | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Parada-Turska, J; Turski, WA | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Colpaert, FC; Koek, W; Woods, JH | 1 |
| France, CP; Winger, GD; Woods, JH | 1 |
| France, CP; Lu, Y; Woods, JH | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS; Hutchison, AJ; Liebman, JM; Wilson, DE | 1 |
| Angst, C; Bernard, PS; Blanchard, L; de Jesus, R; Hutchison, AJ; Jackson, RH; Murphy, DE; Schneider, J; Williams, M; Wilusz, EJ | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| France, CP; Ornstein, P; Woods, JH | 1 |
| Chapman, AG; Hutchison, A; Lehmann, J; Meldrum, BS; Tsai, C; Wood, PL | 1 |
| Hurt, SD; Hutchison, AJ; Murphy, DE; Sills, MA; Williams, M | 1 |
| Loo, PS; Sills, MA; Williams, M | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
| Boast, CA; Etienne, PE; Gerhardt, SC; Lehmann, J; Liebman, JM; Pastor, G | 1 |
| Boast, CA; Pastor, G | 1 |
| Alagarsamy, S; Johnson, KM; Lonart, G | 1 |
| Fedele, E; Raiteri, M; Versace, P | 1 |
| Hoffman, PL; Iorio, KR; Snell, LD; Tabakoff, B | 1 |
| Kanthan, R; Shuaib, A; Waqar, T; Wishart, T | 1 |
| Hakim, AM; Hogan, MJ; Takizawa, S | 1 |
| Giffard, RG; Maier, CM; Pérez-Pinzón, MA; Steinberg, GK; Sun, GH; Yoon, EJ | 1 |
| Baron, SP; Woods, JH | 1 |
| Calligaro, DO; Monn, JA; O'Malley, PJ | 1 |
| French, ED; Wang, T | 1 |
| Ali, SF; Bowyer, JF; Holson, RR; Newport, GD; Slikker, W | 1 |
| Barrionuevo, G; Fleck, MW; Henze, DA; Palmer, AM | 1 |
| Ferkany, JW; Karbon, EW; Price, CH; Saab, OH; Sweetnam, PM; Wroblewski, JT | 1 |
| Anvelt, J; Claesson, A; Kühn, I; Martin, I; Vares, L | 1 |
| Gaspary, HL; Graham, SH; Simon, RP | 1 |
| Kemp, JA; Ochu, E; Priestley, T | 1 |
| Lock, EA; Trainor, A; Widdowson, PS | 1 |
| Pèzzola, A; Popoli, P; Sagratella, S | 1 |
| Aizenman, E; Blitzblau, RC; Hartnett, KA; Rosenberg, PA; Speliotes, EK | 1 |
| Bullock, R; Fujisawa, H; Graham, DI; Kuroda, Y; Strebel, S | 1 |
| Hayes, MJ; Khemani, L; Powell, ML | 1 |
| Hunter, JC; Singh, L | 1 |
| Ijaz, S; McCrea, S; Shuaib, A; Wishart, T | 1 |
| Ask, AL; Fowler, CJ; Sandberg, MP | 1 |
| Breese, GR; Criswell, HE; Johnson, KB; Mueller, RA | 1 |
| Berge, OG; Karlsson, U; Näsström, J | 1 |
| Chan, P; Di Monte, DA; Langston, JW | 1 |
| Clark, WM; Madden, KP; Zivin, JA | 1 |
| Berge, OG; Böö, E; Näsström, J; Ståhlberg, M | 1 |
| French, ED; Mura, A; Wang, T | 1 |
| Breese, GR; Criswell, HE; Simson, PE | 1 |
| Allen, NK; Arnold, MB; Bleisch, T; Borromeo, PS; Leander, JD; Lodge, D; Lugar, CW; Ornstein, PL; Schoepp, DD | 1 |
| Lehmann, JC; Miller, RD; Monsul, NT; Vender, JR | 1 |
| Lu, X; Sinha, AK; Weiss, HR | 1 |
| Domenici, MR; Fortuna, S; Lorenzini, P; Michalek, H; Sagratella, S; Scotti de Carolis, A | 1 |
| Li, HB; Matsumoto, K; Tohda, M; Watanabe, H; Yamamoto, M | 1 |
| Boon, F; Cain, DP; Saucier, D | 1 |
| Dalton, ML; Gadson, PF; Rosenquist, TH; Wrenn, RW | 1 |
| Berge, OG; Claesson, A; Edvinsson, KM; Kallin, E; Larsson, U; Molin, H; Pelcman, B; Swahn, BM | 1 |
| Abou-Gharbia, M; Bramlett, DR; Garrison, DT; Kinney, WA; Kowal, DM; Miller, TL; Moyer, JA; Schmid, J; Tasse, RP; Zaleska, MM | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Juul, N; Marshall, LF; Marshall, SB; Morris, GF | 1 |
| Young, JS | 1 |
| Aizenman, E; Blitzblau, RC; Du, S; Leszkiewicz, DN; Rosenberg, PA; Sinor, JD; Venneti, S | 1 |
| Baron, KT; Campbell, C; Padua, RA; Thayer, SA; Wang, GJ | 1 |
| Barber, PA; Buchan, AM; Hill, MD; Hoyte, L | 1 |
| Bado, M; Grilli, M; Marchi, M; Parodi, M; Raiteri, M; Risso, F | 1 |
| Grilli, M; Marchi, M; Merlo-Pich, E; Pittaluga, A | 1 |
| Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M | 1 |
1 review(s) available for selfotel and n-methylaspartate
| Article | Year |
|---|---|
The rise and fall of NMDA antagonists for ischemic stroke.
Topics: Animals; Brain Ischemia; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Antagonists; Guanidines; Humans; Indoles; Ischemia; N-Methylaspartate; Neurons; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Stroke | 2004 |
1 trial(s) available for selfotel and n-methylaspartate
| Article | Year |
|---|---|
Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury. The Executive Committee of the International Selfotel Trial.
Topics: Adolescent; Adult; Aged; Blood Pressure; Cerebrovascular Circulation; Craniocerebral Trauma; Critical Care; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glasgow Coma Scale; Humans; Injury Severity Score; Intracranial Hypertension; Male; Middle Aged; N-Methylaspartate; Pipecolic Acids; Prospective Studies; Risk; Treatment Outcome | 2000 |
88 other study(ies) available for selfotel and n-methylaspartate
| Article | Year |
|---|---|
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; N-Methylaspartate; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
N-methyl-D-aspartate antagonists suppress the development of frog symmetric monocular optokynetic nystagmus observed after unilateral visual deprivation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraperitoneal; Magnetics; Microinjections; N-Methylaspartate; Nystagmus, Physiologic; Pipecolic Acids; Rana esculenta; Receptors, N-Methyl-D-Aspartate; Vision, Monocular | 1992 |
Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury.
Topics: Amino Acids; Animals; Brain Injuries; Chromatography, High Pressure Liquid; Dextrorphan; Dialysis; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Male; Memory; N-Methylaspartate; Pipecolic Acids; Piperazines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1992 |
The ES-242s, novel N-methyl-D-aspartate antagonists of microbial origin, interact with both the neurotransmitter recognition site and the ion channel domain.
Topics: Animals; Binding, Competitive; Biological Transport; Calcium; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Hippocampus; Ion Channels; Kinetics; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phencyclidine; Pipecolic Acids; Pyrans; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer.
Topics: Animals; Animals, Newborn; Corpus Striatum; Mice; Molecular Structure; N-Methylaspartate; Nerve Degeneration; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism; Structure-Activity Relationship; Tetrazoles; X-Ray Diffraction | 1992 |
Competitive NMDA receptor antagonists attenuate phencyclidine-induced excitations of A10 dopamine neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Binding, Competitive; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1992 |
Protection by N-methyl-D-aspartate receptor antagonists against impairment of working memory in rats following transient cerebral ischemia.
Topics: Animals; Dextrorphan; Dizocilpine Maleate; Ischemic Attack, Transient; Memory; N-Methylaspartate; Pipecolic Acids; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Hippocampus; HIV Envelope Protein gp120; N-Methylaspartate; Neurons; Nitrendipine; Pipecolic Acids; Rats; Tetrodotoxin | 1992 |
Effects of CGS 19755 and dizocilpine (MK 801) on delayed time discrimination performance.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Male; Mental Recall; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Time Perception | 1992 |
Excitatory amino acids and the actions of cocaine.
Topics: Animals; Caffeine; Cocaine; Dextromethorphan; Dizocilpine Maleate; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Pipecolic Acids; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Stereoisomerism; Stereotyped Behavior | 1992 |
The action of CGS-19755 on the redox enhancement of NMDA toxicity in rat cortical neurons in vitro.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dithiothreitol; Electrophysiology; N-Methylaspartate; Neurons; Oxidation-Reduction; Pipecolic Acids; Rats | 1992 |
Sodium nitroprusside blocks NMDA receptors via formation of ferrocyanide ions.
Topics: Animals; Calcium; Female; Ferrocyanides; Mice; N-Methylaspartate; Neurons; Nitroprusside; Pipecolic Acids; Pregnancy; Receptors, N-Methyl-D-Aspartate | 1992 |
Modulation of NMDA excitotoxicity by redox reagents.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dithionitrobenzoic Acid; Dithiothreitol; Embryo, Mammalian; Glycine; N-Methylaspartate; Neurons; Neurotoxins; Oxidation-Reduction; Pipecolic Acids; Rats; Xanthine; Xanthine Oxidase; Xanthines | 1992 |
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.
Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1991 |
Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Extracellular Space; Glutamates; Glutamic Acid; Glutamine; N-Methylaspartate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
In vivo distribution of CGS-19755 within brain in a model of focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Electrocoagulation; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Reference Values; Tissue Distribution | 1992 |
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Ibotenic Acid; Indicators and Reagents; Kainic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Tetrazoles | 1991 |
The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of competitive N-methyl-D-aspartate antagonists on midbrain dopamine neurons: an electrophysiological and behavioral comparison to phencyclidine.
Topics: Amino Acids; Amphetamine; Animals; Behavior, Animal; Dopamine; Electrophysiology; Limbic System; Male; Mesencephalon; Motor Activity; N-Methylaspartate; Neurons; Nucleus Accumbens; Oxidopamine; Phencyclidine; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of NMDA receptor ligands on sensorimotor gating in the rat.
Topics: Acoustic Stimulation; Amino Acids; Animals; Dizocilpine Maleate; Ligands; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Startle | 1991 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action.
Topics: Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Electroshock; Female; Injections, Intraperitoneal; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures; Tetrazoles; Tritium | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks.
Topics: Animals; Avoidance Learning; Dizocilpine Maleate; Male; Memory; Mice; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate; Reference Values | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Injections, Intraperitoneal; Kainic Acid; Male; Mice; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys.
Topics: Analgesics; Anesthetics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Ketamine; Macaca mulatta; N-Methylaspartate; Pipecolic Acids; Piperidines; Reaction Time; Respiration; Video Recording | 1990 |
Interactions between N-methyl-D-aspartate and CGS 19755 administered intramuscularly and intracerebroventricularly in pigeons.
Topics: Animals; Behavior, Animal; Catalepsy; Columbidae; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Injections, Intramuscular; Injections, Intraventricular; N-Methylaspartate; Pipecolic Acids; Time Factors | 1990 |
Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Conflict, Psychological; Discrimination Learning; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1989 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Pipecolic Acids; Piperidines | 1989 |
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic GMP; Harmaline; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.
Topics: Animals; Aspartic Acid; Brain; Intracellular Membranes; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The NMDA antagonists, CPP and CGS 19755, lack affinity for central benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Flunitrazepam; In Vitro Techniques; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Rats; Receptors, GABA-A | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
Topics: Animals; Aspartic Acid; Brain; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Motor Activity; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines | 1988 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
The role of P-type calcium channels in the depolarization-induced activation of nitric oxide synthase in frontal cortex.
Topics: Amiloride; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; Citrulline; Enzyme Activation; Frontal Lobe; In Vitro Techniques; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroarginine; omega-Conotoxins; Peptides; Pipecolic Acids; Polyamines; Potassium; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger | 1994 |
Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Electric Stimulation; Kainic Acid; Ketamine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons, Afferent; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley | 1993 |
Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Glycine; Intracellular Fluid; Kinetics; Magnesium Sulfate; N-Methylaspartate; Naphthalenes; Neurons; Pipecolic Acids; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Post-ischemic therapy with CGS-19755 (alone or in combination with hypothermia) in gerbils.
Topics: Animals; Brain Ischemia; Combined Modality Therapy; Gerbillinae; Hypothermia, Induced; Injections, Intraperitoneal; Male; Maze Learning; N-Methylaspartate; Pipecolic Acids; Prosencephalon | 1995 |
In vitro binding of [3H]nimodipine and [3H]CGS-19755 to rat brain in focal cerebral ischemia.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Brain Ischemia; Male; N-Methylaspartate; Nimodipine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Correlation of CGS 19755 neuroprotection against in vitro excitotoxicity and focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Evoked Potentials, Somatosensory; In Vitro Techniques; Magnetic Resonance Imaging; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Pipecolic Acids; Rabbits | 1995 |
Dipsogenic effects of excitatory amino acid agonists in pigeons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Columbidae; Drinking; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1993 |
beta-Amyloid (25-35) or substance P stimulates [3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biguanides; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Substance P | 1993 |
Electrophysiological evidence for the existence of NMDA and non-NMDA receptors on rat ventral tegmental dopamine neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Electrophysiology; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tegmentum Mesencephali | 1993 |
Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1993 |
Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Evoked Potentials; Glucose; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pipecolic Acids; Pyramidal Tracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tritium | 1993 |
The envelope glycoprotein of HIV-1 alters NMDA receptor function.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; HIV Envelope Protein gp120; N-Methylaspartate; Oocytes; Phencyclidine; Pipecolic Acids; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus | 1993 |
An alternative synthesis of the NMDA antagonist CGS 19755 via free radical carbamoylation of ethyl isonicotinate.
Topics: Free Radicals; Isonicotinic Acids; Molecular Structure; N-Methylaspartate; Oxidation-Reduction; Pipecolic Acids | 1995 |
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis.
Topics: Analysis of Variance; Animals; Binding, Competitive; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; N-Methylaspartate; Necrosis; Neurons; Observer Variation; Pipecolic Acids; Prosencephalon; Pyrimidines; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Receptors, AMPA; Reperfusion Injury | 1994 |
Subtypes of NMDA receptor in neurones cultured from rat brain.
Topics: Animals; Brain; Brain Chemistry; Cells, Cultured; Glycine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
NMDA receptors in rat cerebellum and forebrain: subtle differences in pharmacology and modulation.
Topics: Animals; Binding Sites; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Male; Models, Neurological; N-Methylaspartate; Pipecolic Acids; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1995 |
Diphenylhydantoin potentiates the EEG and behavioural effects induced by N-methyl-D-aspartate antagonists in rats.
Topics: Animals; Behavior, Animal; Cortical Synchronization; Dizocilpine Maleate; Drug Synergism; Electroencephalography; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Pipecolic Acids; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1994 |
Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Binding, Competitive; Cell Survival; Cells, Cultured; Cerebral Cortex; Dendrites; Dizocilpine Maleate; Embryo, Mammalian; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model.
Topics: Acute Disease; Animals; Disease Models, Animal; Dizocilpine Maleate; Hematoma, Subdural; Hemodynamics; Intracranial Pressure; Male; Mannitol; N-Methylaspartate; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Quantitative determination of the NMDA antagonist cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS 19755) in human plasma using capillary gas chromatography/mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; N-Methylaspartate; Pipecolic Acids; Quality Control | 1994 |
Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat.
Topics: Analgesics; Animals; Formaldehyde; Inflammation; Male; N-Methylaspartate; Nociceptors; Pain Measurement; Pipecolic Acids; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Mortality in gerbils with repetitive ischemia: CGSGS-19755/hypothermia therapy.
Topics: Animals; Brain Ischemia; Cell Death; Combined Modality Therapy; Gerbillinae; Hypothermia, Induced; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Prosencephalon; Recurrence | 1994 |
Characterization of [3H]CGS 19755 binding sites in the rat spinal cord.
Topics: Animals; Binding Sites; Cerebral Cortex; Humans; Infant, Newborn; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Membranes; Tritium | 1994 |
Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.
Topics: alpha-Methyltyrosine; Animals; Animals, Newborn; Behavior, Animal; Brain; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Gene Expression; Genes, fos; Levodopa; Male; Methyltyrosines; N-Methylaspartate; Pipecolic Acids; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Systemic or intracerebroventricular injection of NMDA receptor antagonists attenuates the antinociceptive activity of intrathecally administered NMDA receptor antagonists.
Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Mice; Mice, Inbred Strains; N-Methylaspartate; Pain; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Skin Temperature; Spinal Cord; Time Factors | 1993 |
MK-801 temporarily prevents MPTP-induced acute dopamine depletion and MPP+ elimination in the mouse striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Drug Interactions; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Pipecolic Acids; Time Factors | 1993 |
Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits.
Topics: Animals; Ischemia; N-Methylaspartate; Paraplegia; Pipecolic Acids; Rabbits; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrazoles; Time Factors | 1993 |
Tissue distribution of two NMDA receptor antagonists, [3H]CGS 19755 and [3H]MK-801, after intrathecal injection in mice.
Topics: Animals; Dizocilpine Maleate; Injections, Spinal; Male; Mice; N-Methylaspartate; Pain Measurement; Pipecolic Acids; Reaction Time; Receptors, N-Methyl-D-Aspartate; Tissue Distribution | 1993 |
MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Illicit Drugs; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Tegmentum Mesencephali; Vibrissae | 1993 |
Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses.
Topics: Animals; Brain; Electrophysiology; Ethanol; Inferior Colliculi; Iontophoresis; Male; N-Methylaspartate; Neurons; Osmosis; Pipecolic Acids; Rats; Rats, Sprague-Dawley | 1993 |
Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carboxylic Acids; Cerebral Cortex; Isoquinolines; Kainic Acid; Kinetics; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Radioligand Assay; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Tritium | 1996 |
NMDA- and endothelin-1-induced increases in blood-brain barrier permeability quantitated with Lucifer yellow.
Topics: Animals; Blood-Brain Barrier; Endothelins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Isoquinolines; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Wistar | 1996 |
Effect of up-regulation of NMDA receptors on cerebral O2 consumption and blood flow in rat.
Topics: Animals; Brain; Cerebrovascular Circulation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gases; Hemodynamics; Male; N-Methylaspartate; Oxygen Consumption; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 1996 |
Glutamate-dependent mechanisms in the induction of a calcium long-term potentiation-like phenomenon.
Topics: Alanine; Animals; Brain Chemistry; Calcium; Cyclazocine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Narcotic Antagonists; Pipecolic Acids; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1996 |
NMDA antagonists potentiate scopolamine-induced amnesic effect.
Topics: Amnesia; Animals; Cholinergic Antagonists; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Learning Disabilities; Male; Maze Learning; Memory, Short-Term; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Wistar; Scopolamine | 1997 |
Testing hypotheses of spatial learning: the role of NMDA receptors and NMDA-mediated long-term potentiation.
Topics: Amino Acids; Animals; Behavior, Animal; Discrimination Learning; Electrophysiology; Excitatory Amino Acid Antagonists; Learning; Long-Term Potentiation; Male; Maze Learning; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Space Perception | 1997 |
Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells.
Topics: Aorta, Abdominal; Aorta, Thoracic; Cardiovascular Diseases; Cell Division; Diglycerides; Dizocilpine Maleate; DNA; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Glutamic Acid; Homocysteine; Humans; Immunoblotting; Muscle, Smooth, Vascular; N-Methylaspartate; Oncogenes; Pipecolic Acids; Polymerase Chain Reaction; Precipitin Tests; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; RNA | 1997 |
Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity.
Topics: Analgesics; Animals; Binding Sites; Binding, Competitive; Excitatory Amino Acid Antagonists; Kinetics; Mice; N-Methylaspartate; Organophosphonates; Pain Measurement; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1997 |
Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Ischemic Attack, Transient; Mice; Models, Chemical; N-Methylaspartate; Organophosphonates; Pipecolic Acids; Piperazines; Rats | 1998 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Cerebral perfusion pressure or intracranial pressure?
Topics: Blood Pressure; Cerebrovascular Circulation; Craniocerebral Trauma; Critical Care; Critical Pathways; Excitatory Amino Acid Antagonists; Humans; Intracranial Pressure; Multicenter Studies as Topic; N-Methylaspartate; Pipecolic Acids; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome | 2000 |
NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette Transporters; Cell Death; Cells, Cultured; Cerebral Cortex; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Intracellular Fluid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
NMDA-evoked consumption and recovery of mitochondrially targeted aequorin suggests increased Ca2+ uptake by a subset of mitochondria in hippocampal neurons.
Topics: Aequorin; Animals; Calcium; Calcium Signaling; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cytoplasm; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Indoles; Ionophores; Luminescent Measurements; Mitochondria; N-Methylaspartate; Neurons; Pipecolic Acids; Rats | 2003 |
Nicotine exerts a permissive role on NMDA receptor function in hippocampal noradrenergic terminals.
Topics: Animals; Calcium; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Male; Mecamylamine; N-Methylaspartate; Nerve Endings; Nicotine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2004 |
NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; N-Methylaspartate; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Pipecolic Acids; Potassium; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors; Tritium | 2009 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |