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selenium and ebselen

selenium has been researched along with ebselen in 101 studies

Research

Studies (101)

TimeframeStudies, this research(%)All Research%
pre-199034 (33.66)18.7374
1990's34 (33.66)18.2507
2000's12 (11.88)29.6817
2010's13 (12.87)24.3611
2020's8 (7.92)2.80

Authors

AuthorsStudies
Morita, I; Murota, S; Ochi, H1
Geiger, PG; Girotti, AW; Lin, F2
Cotgreave, IA; Engman, L; Morgenstern, R1
Fox, JM1
Brüne, B; Dimmeler, S; Ullrich, V1
Liehr, JG; Roy, D1
Kappus, H; Reinhold, C1
Ferrell, LD; Grendell, JH; Lüthen, R; Niederau, C; Niederau, M; Strohmeyer, G; Ude, K1
Gustafson, DL; Pritsos, CA1
Hayaishi, O; Islam, F; Morii, H; Watanabe, Y1
Ishibashi, S; Masayasu, H; Ohtsuka, T; Okamura, N; Wakamura, K1
Czyrski, JA; Inglot, AD1
Jackson, RL; Thomas, CE1
Brüne, B; Diewald, B; Ullrich, V1
Blake, DR; Dowling, EJ; Graf, E; Leyck, S; Parnham, MJ1
Hermenegildo, C; Higueras, V; Monsalve, E; Nies, E; Puertas, FJ; Romero, FJ1
Asano, T; Hanamura, T; Johshita, H; Masayasu, H; Matsui, T; Sasaki, T; Takakura, K1
Burkart, V; Flechner, I; Kawai, K; Kiesel, U; Kolb, H; Maruta, K1
Ganther, HE; Ip, C1
Inglot, AD; Młochowski, J; Piasecki, E; Syper, L; Zielińska-Jenczylik, J1
Bast, A; De Rooij, BM; Haenen, GR; Vermeulen, NP1
Bast, A; Leurs, R; Timmerman, H2
Leyck, S; Parnham, MJ1
Narayanaswami, V; Sies, H2
Beil, W; Sewing, KF; Staar, U1
Baldock, RJ; Coid, CR; Doré, CJ; Gower, JD; Green, CJ; O'Sullivan, AM1
Baldew, GS; de Goeij, JJ; Los, G; McVie, JG; van der Valk, MA; Vermeulen, NP1
Asmus, KD; Narayanaswami, V; Schöneich, C; Sies, H1
Kondo, M; Morita, Y; Naito, Y; Oyamada, H; Sugino, S; Takahashi, S; Takemura, T; Tanigawa, T; Ueda, S; Yoshikawa, T1
Parnham, MJ2
Brattsand, R; Cotgreave, IA; Johansson, U; Moldéus, PW; Westergren, G1
Huang, RR; Raghavan, PR; Spector, A; Wilson, SR; Zucker, PA1
Bhattacherjee, P; Hurst, JS; Paterson, CA; Pierce, WM1
Cotgreave, IA; Duddy, SK; Kass, GE; Moldéus, P; Thompson, D1
Cinti, DL; Cook, L; Laguna, JC; Nagi, MN2
Hüther, AM; Parnham, MJ; Sauer, A; Zhang, Y1
Akasaki, M; Kurebayashi, Y; Tabuchi, Y1
Biedermann, J; Bittner, C; Dereu, N; Leyck, S; Parnham, MJ; Wetzig, H1
Fujimoto, T; Nozawa, R; Yokota, T1
Ichikawa, S; Ishibashi, S; Katayama, T; Masayasu, H; Ohtsuka, T; Okamura, N; Omura, K1
Kühn-Velten, N; Sies, H1
Safayhi, H; Tiegs, G; Wendel, A1
Borbe, HO; Fischer, H; Kuhl, P; Parnham, MJ; Römer, A1
Borbe, HO; Fischer, H; Kuhl, P; Römer, A; Safayhi, H1
Kuhl, P; Leyck, S; Parnham, MJ; Schalkwijk, J; van den Berg, WB1
Otter, R; Tiegs, G; Wendel, A1
Combs, GF; Mercurio, SD1
Feige, M; Römer, A; Terlinden, R1
Fischer, H; Löhr, JP; Römer, A; Terlinden, R1
Graf, E; Parnham, MJ1
Fischer, H; Gabriel, H; Müller, A; Römer, A; Sies, H; Terlinden, R1
Coassin, M; Maiorino, M; Roveri, A; Ursini, F1
Hayashi, M; Slater, TF1
Konz, KH; Tiegs, G; Wendel, A1
Sies, H1
Berggren, M; Cotgreave, IA; Moldéus, PW; Sandy, MS; Smith, MT1
Tiegs, G; Wendel, A1
Braswell, L; Offenbacher, S; Van Dyke, TE1
Cadenas, E; Sies, H1
Cadenas, E; Graf, P; Müller, A; Sies, H1
Fausel, M; Otter, R; Safayhi, H; Tiegs, G; Wendel, A1
Kindt, S; Parnham, MJ1
Geiger, PG; Girotti, AW; Thomas, JP1
Aeberhard, E; Chaudhuri, G; Farias-Eisner, R; Fukuto, JM1
Bai, Y; Liu, J; Luo, G; Mu, Y; Ren, X; Shen, J1
Holmgren, A1
Sevanian, A; Shen, L1
Giles, GI; Giles, NM; Gutowski, NJ; Jacob, C1
Alborch, E; Burguete, MC; Marín, N; Pérez-Asensio, FJ; Pitarch, C; Romero, FJ; Salom, JB; Torregrosa, G1
Avenell, A; Barr, J; Engelhardt, T; Noble, DW1
Huang, K; Wu, Q1
Baljinnyam, E; Fujino, T; Fukuzawa, J; Hasebe, N; Kikuchi, K; Matsusaka, T; Morihira, M; Sumitomo, K; Ushikubi, F1
Furukawa, S; He, Y; Koketsu, M; Nishina, A; Sekiguchi, A1
Boeck, CR; Ghisleni, G; Mioranzza, S; Porciúncula, LO; Rocha, JB; Souza, DO1
Alberto, EE; Braga, AL; Rocha, JB; Roos, DH; Soares, LC; Sudati, JH1
Mecinović, J; Rose, NR; Schofield, CJ; Seden, PT; Sekirnik, R; Thalhammer, A1
Mlochowski, J; Piasecki, E; Pietka-Ottlik, M; Potaczek, P1
Fujimura, M; Usuki, F; Yamashita, A1
Nogueira, CW; Rocha, JB1
Ashe, AJ; Cai, W; Meyerhoff, ME; Wu, J; Xi, C1
Lei, XG; Wang, X; Yun, JW1
Butcher, RJ; Engman, L; Poon, JF; Singh, VP1
Guru Row, TN; Mugesh, G; Satheeshkumar, K; Thomas, SP1
Butcher, RJ; Engman, L; Lu, X; Mestres, G; Ott, MK; Poon, JF; Singh, VP1
Huang, L; Li, W; Li, X; Liu, Z; Luo, Z; Sun, Y; Wang, Y; Wang, Z; Wu, R1
Akhyari, P; Bilgic, E; Boeken, U; Döhrn, L; Engels, M; Kellermann, K; Lichtenberg, A; Pinto, A; Steinbrenner, H; Wollschläger, L1
Aschner, M; Oliveira, CS; Piccoli, BC; Rocha, JBT1
Carvalho, FB; Fernandes, MC; Fulco, BCW; Klann, IP; Martini, F; Nogueira, CW; Rahmeier, FL; Rosa, SG1
Berry, MJ; Pitts, MW; Seale, LA; Torres, DJ1
Rayman, MP; Saad, R; Taylor, EW; Zhang, J1
Barbosa, NV; Nogueira, CW; Rocha, JBT1
Ji, L; Kong, L; Li, S; Liu, X; Lu, D; Luo, H; Peng, W; Qu, L; Wang, C; Wang, X; Yin, F1
Amporndanai, K; Jin, Z; Liu, ZJ; Meng, X; O'Neill, PM; Rao, Z; Rogers, M; Samar Hasnain, S; Shang, W; Yang, H; Zhang, L; Zhao, Y1
Sancineto, L; Santi, C; Scimmi, C1
Gong, M; Hong, G; Shi, H; Wen, R; Wu, Y; Xu, S; Xu, Y1
Feng, C; Lei, XG; Sun, Z; Wu, K1

Reviews

12 review(s) available for selenium and ebselen

ArticleYear
Selenium: nutritional implications and prospects for therapeutic medicine.
    Methods and findings in experimental and clinical pharmacology, 1992, Volume: 14, Issue:4

    Topics: Animals; Azoles; Glutathione Peroxidase; Humans; Isoindoles; Organoselenium Compounds; Oxidation-Reduction; Selenium

1992
The pharmacology of ebselen.
    Agents and actions, 1991, Volume: 32, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Glutathione Peroxidase; Inflammation; Isoindoles; Organoselenium Compounds; Selenium; Structure-Activity Relationship

1991
Biological activities and clinical potential of Ebselen.
    Advances in experimental medicine and biology, 1990, Volume: 264

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Chemical and Drug Induced Liver Injury; Humans; Isoindoles; Organoselenium Compounds; Selenium

1990
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions.
    Biochemical pharmacology, 1987, Oct-01, Volume: 36, Issue:19

    Topics: Animals; Azoles; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Inflammation; Isoindoles; Organoselenium Compounds; Oxidation-Reduction; Selenium

1987
Oxidative stress: excited oxygen species and enzyme activity.
    Advances in enzyme regulation, 1985, Volume: 23

    Topics: Aldehydes; Animals; Azoles; Cell Survival; Electron Transport; Ethanol; Free Radicals; Isoindoles; Lipid Metabolism; Organoselenium Compounds; Oxidation-Reduction; Oxygen; Pargyline; Peroxides; Quinones; Selenium

1985
Antioxidant function of thioredoxin and glutaredoxin systems.
    Antioxidants & redox signaling, 2000,Winter, Volume: 2, Issue:4

    Topics: Amino Acid Sequence; Animals; Antioxidants; Azoles; Base Sequence; DNA, Complementary; Gene Expression; Glutaredoxins; Humans; Isoindoles; Models, Molecular; Organoselenium Compounds; Oxidoreductases; Proteins; Rats; Selenium; Selenocysteine; Thioredoxin-Disulfide Reductase; Thioredoxins

2000
Selenium supplementation for critically ill adults.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Adult; Antioxidants; Azoles; Critical Illness; Dietary Supplements; Humans; Isoindoles; Organoselenium Compounds; Randomized Controlled Trials as Topic; Selenium

2004
Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds.
    Archives of toxicology, 2011, Volume: 85, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Azoles; Humans; Isoindoles; Organoselenium Compounds; Oxidative Stress; Selenium; Sulfhydryl Compounds

2011
Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity.
    Advances in neurobiology, 2017, Volume: 18

    Topics: Antidotes; Azoles; Benzene Derivatives; Brain; Humans; Isoindoles; Mercury Poisoning; Mercury Poisoning, Nervous System; Neurotoxicity Syndromes; Organoselenium Compounds; Selenium; Selenoproteins

2017
Selenium and selenoproteins in viral infection with potential relevance to COVID-19.
    Redox biology, 2020, Volume: 37

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cytokines; Humans; Inflammation; Isoindoles; Organoselenium Compounds; SARS-CoV-2; Selenium; Selenoproteins; Viral Protease Inhibitors

2020
Toxicology and pharmacology of synthetic organoselenium compounds: an update.
    Archives of toxicology, 2021, Volume: 95, Issue:4

    Topics: Amino Acids; Animals; Azoles; Humans; Isoindoles; Molecular Structure; Organoselenium Compounds; Selenium; Selenoproteins; Sulfhydryl Compounds

2021
Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation.
    Molecules (Basel, Switzerland), 2021, Jul-12, Volume: 26, Issue:14

    Topics: Animals; Anti-Infective Agents; Antioxidants; Antiviral Agents; Azoles; Biomimetics; Cyclooxygenase Inhibitors; Glutathione Peroxidase; Humans; Isoindoles; Molecular Structure; Neuroprotective Agents; Organoselenium Compounds; Selenium; Selenoproteins

2021

Other Studies

89 other study(ies) available for selenium and ebselen

ArticleYear
Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid.
    Archives of biochemistry and biophysics, 1992, May-01, Volume: 294, Issue:2

    Topics: Animals; Antioxidants; Azoles; Buthionine Sulfoximine; Carotid Arteries; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Isoindoles; Kinetics; Leukotrienes; Lipid Peroxides; Maleates; Methionine Sulfoximine; Organoselenium Compounds; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Selenium; Sodium Selenite; Thiazoles; Thiazolidines

1992
Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells.
    Cancer research, 1992, Oct-01, Volume: 52, Issue:19

    Topics: Animals; Azoles; Catalase; Cell Death; Glutathione; Glutathione Peroxidase; Humans; Isoindoles; Leukemia L1210; Leukemia, Experimental; Lipid Peroxidation; Mice; Organoselenium Compounds; Phospholipid Hydroperoxide Glutathione Peroxidase; Photochemotherapy; Pyrimidinones; Radiation Tolerance; Radiation-Sensitizing Agents; Selenium

1992
Determination of the relative contributions of the diselenide and selenol forms of ebselen in the mechanism of its glutathione peroxidase-like activity.
    Chemico-biological interactions, 1992, Sep-14, Volume: 84, Issue:1

    Topics: Anilides; Azoles; Benzamides; Dithiothreitol; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Kinetics; Organoselenium Compounds; Selenium; Selenium Compounds

1992
Ebselen prevents inositol (1,4,5)-trisphosphate binding to its receptor.
    Biochemical pharmacology, 1991, Aug-08, Volume: 42, Issue:5

    Topics: Anilides; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Blood Platelets; Calcium; Calcium Channels; Disulfides; Dose-Response Relationship, Drug; Fura-2; Heparin; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoindoles; Microsomes; Organoselenium Compounds; Platelet Activation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Selenium; Sulfhydryl Compounds

1991
Inhibition of estrogen-induced kidney carcinogenesis in Syrian hamsters by modulators of estrogen metabolism.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: Animals; Antioxidants; Azoles; Butylated Hydroxyanisole; Cricetinae; Dicumarol; Estradiol; Glutathione Peroxidase; Isoindoles; Kidney Neoplasms; Male; Mercaptoethanol; Mesna; Mesocricetus; NADPH-Ferrihemoprotein Reductase; Organoselenium Compounds; Quinone Reductases; Quinones; Selenium

1990
Inhibition of bleomycin-induced toxic effects by antioxidants in human malignant melanoma cells.
    Advances in experimental medicine and biology, 1990, Volume: 264

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Bleomycin; Female; Humans; Isoindoles; Melanoma; Organoselenium Compounds; Propyl Gallate; Pyrogallol; Selenium; Tumor Cells, Cultured

1990
Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.
    Pancreas, 1991, Volume: 6, Issue:3

    Topics: Acute Disease; Amylases; Animals; Azoles; Ceruletide; Choline Deficiency; Diet; Disease Models, Animal; Ethionine; Female; Free Radicals; Isoindoles; Male; Mice; Organ Size; Organoselenium Compounds; Pancreas; Pancreatitis; Selenium

1991
Inhibition of mitomycin C's aerobic toxicity by the seleno-organic antioxidant PZ-51.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:3

    Topics: Acetylcysteine; Aerobiosis; Animals; Antineoplastic Agents; Antioxidants; Azoles; Cell Hypoxia; Cell Line; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Isoindoles; Mice; Mitomycin; Mitomycins; Organoselenium Compounds; Porfiromycin; Selenium; Tumor Cells, Cultured

1991
Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds.
    Archives of biochemistry and biophysics, 1991, Aug-15, Volume: 289, Issue:1

    Topics: Animals; Azoles; Brain; Chlorides; Cyclooxygenase Inhibitors; Dithiothreitol; Dose-Response Relationship, Drug; Isoindoles; Kinetics; Male; Metals; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenious Acid; Selenium; Selenium Compounds; Sulfur

1991
Mechanism for the inhibitory effect of a seleno-organic compound, Ebselen, and its analogues on superoxide anion production in guinea pig polymorphonuclear leukocytes.
    Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Enzyme Activation; Female; Guinea Pigs; Horses; Isoindoles; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Organoselenium Compounds; Protein Kinase C; Selenium; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Thiazoles

1990
Mitogenic activity of selenoorganic compounds in human peripheral blood leukocytes.
    Experientia, 1991, Jan-15, Volume: 47, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Azoles; Benzamides; Cell Division; Cells, Cultured; DNA Replication; Humans; Isoindoles; Leukocytes; Mitogens; Organoselenium Compounds; Selenium; Thymidine; Tritium

1991
Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Azo Compounds; Azoles; Cholesterol Esters; Chromatography, High Pressure Liquid; Copper; Humans; Isoindoles; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Organoselenium Compounds; Oxidation-Reduction; Selenium

1991
Ebselen affects calcium homeostasis in human platelets.
    Biochemical pharmacology, 1991, Jun-15, Volume: 41, Issue:12

    Topics: Anilides; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Autoradiography; Azoles; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Fluorescence; Homeostasis; Humans; Intracellular Fluid; Isoindoles; Microsomes; Organoselenium Compounds; Phosphorylation; Platelet Aggregation; Selenium; Thrombin

1991
Some aspects of cardiac antioxidant defence: Ebselen (PZ 51) treatment increases glutathione peroxidase activity in the rat heart.
    Biochemical Society transactions, 1990, Volume: 18, Issue:6

    Topics: Animals; Antioxidants; Azoles; Glutathione Peroxidase; Heart; Isoindoles; Myocardial Reperfusion Injury; Myocardium; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium

1990
Effects of ebselen (PZ51) on ischaemic brain oedema after focal ischaemia in cats.
    Acta neurochirurgica. Supplementum, 1990, Volume: 51

    Topics: Animals; Antioxidants; Azoles; Brain Edema; Brain Ischemia; Cats; Cerebrovascular Circulation; Isoindoles; Organoselenium Compounds; Reperfusion; Selenium; Time Factors

1990
Effects of radical scavengers on the development of experimental diabetes.
    Diabetes research (Edinburgh, Scotland), 1990, Volume: 13, Issue:2

    Topics: Aging; Animals; Antioxidants; Azoles; Benzamides; Blood Glucose; Butylated Hydroxyanisole; Cysteamine; Diabetes Mellitus, Experimental; Free Radical Scavengers; Isoindoles; Male; Mice; Mice, Inbred ICR; Organoselenium Compounds; Rats; Rats, Inbred BB; Selenium; Thiophenes; Time Factors

1990
Activity of methylated forms of selenium in cancer prevention.
    Cancer research, 1990, Feb-15, Volume: 50, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arsenic; Azoles; Betaine; Drug Synergism; Female; Isoindoles; Mammary Neoplasms, Experimental; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenious Acid; Selenium

1990
Organoselenides as potential immunostimulants and inducers of interferon gamma and other cytokines in human peripheral blood leukocytes.
    Experientia, 1990, Mar-15, Volume: 46, Issue:3

    Topics: Adjuvants, Immunologic; Antiviral Agents; Azoles; Cells, Cultured; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunologic Factors; Interferon Inducers; Interferon-gamma; Isoindoles; Leukocytes; Organometallic Compounds; Organoselenium Compounds; Phytohemagglutinins; Selenium; Stimulation, Chemical; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

1990
Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.
    Molecular pharmacology, 1990, Volume: 37, Issue:3

    Topics: Azoles; Chemical Phenomena; Chemistry; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Isoindoles; Kinetics; Mass Spectrometry; Organoselenium Compounds; Peroxidases; Selenium; Spectrum Analysis; Sulfhydryl Compounds; Thioctic Acid

1990
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
    European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Catechols; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine; Indomethacin; Isoindoles; Isoquinolines; Lung; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Organoselenium Compounds; Piperazines; Potassium Chloride; Selenium; Thiazoles

1990
Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.
    Agents and actions, 1990, Volume: 30, Issue:3-4

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Diclofenac; Edema; Elapid Venoms; Female; Gastric Mucosa; Indomethacin; Isoindoles; Levamisole; Male; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium

1990
Oxidative damage to mitochondria and protection by ebselen and other antioxidants.
    Biochemical pharmacology, 1990, Oct-01, Volume: 40, Issue:7

    Topics: Animals; Antioxidants; Azoles; Ditiocarb; Dose-Response Relationship, Drug; Glutathione; Intracellular Membranes; Isoindoles; Lipid Peroxidation; Luminescent Measurements; Microsomes, Liver; Mitochondria, Liver; Organoselenium Compounds; Rats; Selenium; Thiazoles; Vitamin E

1990
Interaction of the anti-inflammatory seleno-organic compound ebselen with acid secretion in isolated parietal cells and gastric H+/K(+)-ATPase.
    Biochemical pharmacology, 1990, Nov-01, Volume: 40, Issue:9

    Topics: Adenosine Triphosphatases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Biological Transport, Active; Dogs; Gastric Acid; Guinea Pigs; H(+)-K(+)-Exchanging ATPase; Isoindoles; Kidney; Organoselenium Compounds; Parietal Cells, Gastric; Protons; Selenium; Stomach; Swine

1990
Protection against endotoxin-induced foetal resorption in mice by desferrioxamine and ebselen.
    International journal of experimental pathology, 1990, Volume: 71, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Deferoxamine; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Female; Fetal Death; Fetal Resorption; Isoindoles; Mice; Organ Size; Organoselenium Compounds; Pregnancy; Selenium; Spleen

1990
Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.
    Cancer research, 1990, Nov-01, Volume: 50, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azoles; Cisplatin; Drug Administration Schedule; Drug Interactions; Female; Isoindoles; Kidney; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Organoselenium Compounds; Plasmacytoma; Selenium; Time Factors

1990
Reactivity of ebselen and related selenoorganic compounds with 1,2-dichloroethane radical cations and halogenated peroxyl radicals.
    Archives of biochemistry and biophysics, 1990, Volume: 282, Issue:1

    Topics: Antioxidants; Azoles; Cations; Electrochemistry; Ethylene Dichlorides; Free Radicals; Halogens; Isoindoles; Organoselenium Compounds; Oxidation-Reduction; Peroxides; Selenium; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1990
Protection by seleno-organic compound, Ebselen, against acute gastric mucosal injury induced by ischemia-reperfusion in rats.
    Advances in experimental medicine and biology, 1990, Volume: 264

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azoles; Catalase; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Ischemia; Isoindoles; Male; Organoselenium Compounds; Rats; Rats, Inbred Strains; Regional Blood Flow; Reperfusion Injury; Selenium; Superoxide Dismutase; Thiobarbiturates

1990
Antioxidant activity of ebselen and related selenoorganic compounds in microsomal lipid peroxidation.
    Free radical research communications, 1990, Volume: 10, Issue:4-5

    Topics: Adenosine Diphosphate; Animals; Antioxidants; Ascorbic Acid; Azoles; Intracellular Membranes; Iron; Isoindoles; Kinetics; Lipid Peroxidation; Luminescent Measurements; Male; Microsomes; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium; Thiobarbiturates; Vitamin E

1990
The anti-inflammatory activity of Ebselen but not thiols in experimental alveolitis and bronchiolitis.
    Agents and actions, 1988, Volume: 24, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents; Azoles; Bronchiolitis; Cell Count; Dextrans; Gels; Isoindoles; Male; Organoselenium Compounds; Pulmonary Alveoli; Pulmonary Edema; Rats; Rats, Inbred Strains; Selenium; Sulfhydryl Compounds

1988
The synthesis of glutathione peroxidase analogs.
    Lens and eye toxicity research, 1989, Volume: 6, Issue:4

    Topics: Azoles; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Molecular Structure; Organoselenium Compounds; Selenium; Substrate Specificity

1989
Effects of ebselen on arachidonate metabolism by ocular and non-ocular tissues.
    Biochemical pharmacology, 1989, Oct-01, Volume: 38, Issue:19

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Azoles; Dinoprost; Eye; Glutathione; Hydroxyeicosatetraenoic Acids; Isoindoles; Male; Organoselenium Compounds; Rabbits; Rats; Rats, Inbred Strains; Selenium

1989
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?
    Biochemical pharmacology, 1989, Feb-15, Volume: 38, Issue:4

    Topics: Azoles; Granulocytes; Humans; Hydrogen Peroxide; In Vitro Techniques; Isoindoles; NADH, NADPH Oxidoreductases; NADPH Oxidases; Organoselenium Compounds; Oxygen Consumption; Phosphoproteins; Protein Kinase C; Selenium; Superoxides; Tetradecanoylphorbol Acetate

1989
Inhibition of superoxide anion radical production by ebselen (PZ51) and its sulfur analogue (PZ25) in guinea pig alveolar macrophages.
    Biochemistry international, 1989, Volume: 18, Issue:2

    Topics: Animals; Antioxidants; Azoles; Free Radicals; Guinea Pigs; In Vitro Techniques; Isoindoles; Macrophages; Male; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Organoselenium Compounds; Pulmonary Alveoli; Selenium; Superoxides; Tetradecanoylphorbol Acetate; Thiazoles

1989
Action of Ebselen on rat hepatic microsomal enzyme-catalyzed fatty acid chain elongation, desaturation, and drug biotransformation.
    Archives of biochemistry and biophysics, 1989, Feb-15, Volume: 269, Issue:1

    Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; Alcohol Oxidoreductases; Aminopyrine N-Demethylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Biotransformation; Catalysis; Cytochrome b Group; Cytochromes b5; Enoyl-CoA Hydratase; Fatty Acid Desaturases; Fatty Acids; Isoindoles; Male; Malonyl Coenzyme A; Microsomes, Liver; Organoselenium Compounds; Oxidation-Reduction; Rats; Rats, Inbred Strains; Selenium; Stearoyl-CoA Desaturase

1989
Antimalarial properties of ebselen.
    Parasitology research, 1989, Volume: 75, Issue:5

    Topics: Animals; Antimalarials; Antioxidants; Azoles; Cell Line; Humans; Isoindoles; Macrophages; Malaria; Male; Mice; Molecular Structure; Organoselenium Compounds; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinacrine; Selenium

1989
Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:2

    Topics: Animals; Antioxidants; Azoles; Ethanol; Gastric Mucosa; Indomethacin; Isoindoles; Male; Necrosis; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium; Stomach Ulcer

1989
Structure-activity relationships of a series of anti-inflammatory benzisoselenazolones (BISAs).
    Agents and actions, 1989, Volume: 27, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Azoles; Edema; Glutathione Peroxidase; Isoindoles; Lethal Dose 50; Mice; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium; Stomach Ulcer; Structure-Activity Relationship

1989
Susceptibility of methicillin-resistant Staphylococcus aureus to the selenium-containing compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51).
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:8

    Topics: Azoles; Isoindoles; Methicillin; Microbial Sensitivity Tests; Organoselenium Compounds; Penicillin Resistance; Selenium; Staphylococcus aureus

1989
Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen.
    Journal of pharmacobio-dynamics, 1987, Volume: 10, Issue:10

    Topics: Animals; Antioxidants; Azoles; Guinea Pigs; In Vitro Techniques; Isoindoles; NADP; Neutrophils; Organoselenium Compounds; Selenium; Superoxides

1987
Disruption of rat hepatic microsomal electron transport chains by the selenium-containing anti-inflammatory agent Ebselen.
    Archives of biochemistry and biophysics, 1989, Feb-15, Volume: 269, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Electron Transport; Isoindoles; Male; Microsomes, Liver; NADP; Organoselenium Compounds; Oxidation-Reduction; Rats; Rats, Inbred Strains; Selenium; Spectrophotometry, Ultraviolet

1989
Optical spectral studies of ebselen interaction with cytochrome P-450 of rat liver microsomes.
    Biochemical pharmacology, 1989, Feb-15, Volume: 38, Issue:4

    Topics: Animals; Azoles; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoindoles; Male; Microsomes, Liver; Organoselenium Compounds; Rats; Selenium; Serum Albumin, Bovine; Spectrum Analysis; Sulfhydryl Compounds

1989
A novel biologically active seleno-organic compound--V. Inhibition by ebselen (PZ 51) of rat peritoneal neutrophil lipoxygenase.
    Biochemical pharmacology, 1985, Aug-01, Volume: 34, Issue:15

    Topics: Animals; Anti-Inflammatory Agents; Azoles; Glutathione Peroxidase; Hydroxyeicosatetraenoic Acids; Isoindoles; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium

1985
Selective inhibition of leukotriene B4 formation by Ebselen: a novel approach to antiinflammatory therapy.
    Agents and actions, 1986, Volume: 17, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Azoles; Blood Platelets; Humans; In Vitro Techniques; Isoindoles; Leukocytes; Leukotriene A4; Leukotriene B4; Leukotrienes; Organoselenium Compounds; Selenium; Swine

1986
Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer.
    Prostaglandins, 1986, Volume: 31, Issue:6

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Azoles; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydroxyeicosatetraenoic Acids; Isoindoles; Isomerism; Leukocytes; Leukotriene B4; Magnetic Resonance Spectroscopy; Organoselenium Compounds; Prostaglandin-Endoperoxide Synthases; Selenium; Swine

1986
Ebselen: a new approach to the inhibition of peroxide-dependent inflammation.
    International journal of tissue reactions, 1987, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Azoles; Edema; Female; Indomethacin; Inflammation; Isoindoles; Leukotriene B4; Male; Organoselenium Compounds; Peroxides; Piroxicam; Rats; Rats, Inbred Strains; Selenium

1987
Inhibition by ebselen of microsomal NADPH-cytochrome P450-reductase in vitro but not in vivo.
    Biochemical pharmacology, 1986, Sep-15, Volume: 35, Issue:18

    Topics: Animals; Azoles; In Vitro Techniques; Isoindoles; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organoselenium Compounds; Selenium

1986
Synthetic seleno-organic compound with glutathione peroxidase-like activity in the chick.
    Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24

    Topics: Animals; Aurothioglucose; Azoles; Chickens; Edema; Glutathione Peroxidase; Isoindoles; Liver; NADP; Nitrofurantoin; Organoselenium Compounds; Paraquat; Penicillamine; Selenium; Vitamin E Deficiency

1986
Determination of the two major metabolites of ebselen in human plasma by high-performance liquid chromatography.
    Journal of chromatography, 1988, Sep-09, Volume: 430, Issue:2

    Topics: Administration, Oral; Azoles; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoindoles; Organoselenium Compounds; Selenium; Spectrophotometry, Ultraviolet

1988
A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen.
    Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:12

    Topics: Animals; Azoles; Biotransformation; Chromatography, High Pressure Liquid; Female; Humans; Isoindoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Structure; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium; Species Specificity; Swine; Swine, Miniature

1988
A novel biologically active selenooorganic compound--VII. Biotransformation of ebselen in perfused rat liver.
    Biochemical pharmacology, 1988, Mar-15, Volume: 37, Issue:6

    Topics: Animals; Antioxidants; Azoles; Bile; Biotransformation; Isoindoles; Liver; Male; Mass Spectrometry; Organoselenium Compounds; Perfusion; Rats; Rats, Inbred Strains; Selenium

1988
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51).
    Biochemical pharmacology, 1988, Jun-01, Volume: 37, Issue:11

    Topics: Antioxidants; Azoles; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Kinetics; Lipid Peroxides; Organoselenium Compounds; Selenium; Substrate Specificity

1988
Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes.
    Free radical research communications, 1986, Volume: 2, Issue:3

    Topics: Adenosine Diphosphate; Animals; Antioxidants; Ascorbic Acid; Azoles; Carbon Tetrachloride; In Vitro Techniques; Iron; Isoindoles; Lipid Peroxides; Male; Malondialdehyde; Microsomes, Liver; Organoselenium Compounds; Oxygen Consumption; Rats; Selenium

1986
Protection by ebselen against endotoxin shock in rats or mice sensitized by galactosamine.
    Progress in clinical and biological research, 1987, Volume: 236A

    Topics: Animals; Azoles; Chemical and Drug Induced Liver Injury; Fatty Acids, Unsaturated; Galactosamine; Glutathione; Hemodynamics; Isoindoles; Liver; Male; Mice; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium; Shock, Septic

1987
Antioxidant activity in cells and organs.
    The American review of respiratory disease, 1987, Volume: 136, Issue:2

    Topics: Animals; Antioxidants; Azoles; Enzymes; Glutathione; Isoindoles; NADP; Organoselenium Compounds; Selenium

1987
N-acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes.
    Biochemical pharmacology, 1987, Sep-15, Volume: 36, Issue:18

    Topics: Acetylcysteine; Animals; Azoles; Carmustine; Diquat; Glutathione; Hydrogen Peroxide; Isoindoles; Lipid Peroxides; Liver; Male; Organoselenium Compounds; Oxidation-Reduction; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selenium

1987
A novel biologically active seleno-organic compound--VI. Protection by ebselen (PZ 51) against galactosamine/endotoxin-induced hepatitis in mice.
    Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azoles; Chemical and Drug Induced Liver Injury; Dexamethasone; Diethylcarbamazine; Endotoxins; Galactosamine; Glutathione; Glutathione Disulfide; Hepatitis, Animal; Ibuprofen; Indomethacin; Isoindoles; L-Iditol 2-Dehydrogenase; Male; Mice; Organoselenium Compounds; Selenium; Time Factors

1986
Inhibition of gingivitis by topical application of ebselen and rosmarinic acid.
    Agents and actions, 1986, Volume: 19, Issue:5-6

    Topics: Animals; Antioxidants; Azoles; Cinnamates; Depsides; Gingivitis; Isoindoles; Macaca mulatta; Male; Organoselenium Compounds; Rosmarinic Acid; Selenium

1986
A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).
    Biochemical pharmacology, 1984, Oct-15, Volume: 33, Issue:20

    Topics: Animals; Antioxidants; Azoles; Glutathione Peroxidase; In Vitro Techniques; Isoindoles; Lipid Peroxides; Male; Microsomes, Liver; Organoselenium Compounds; Rats; Rats, Inbred Strains; Selenium

1984
A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase.
    Biochemical pharmacology, 1984, Oct-15, Volume: 33, Issue:20

    Topics: Animals; Anti-Inflammatory Agents; Azoles; Cattle; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Isoindoles; Male; Mice; Microsomes, Liver; NADP; Organoselenium Compounds; Selenium

1984
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages.
    Biochemical pharmacology, 1984, Oct-15, Volume: 33, Issue:20

    Topics: Animals; Anti-Inflammatory Agents; Azoles; Dinoprostone; Glucuronidase; Glutathione Peroxidase; In Vitro Techniques; Isoindoles; L-Lactate Dehydrogenase; Luminescent Measurements; Macrophages; Male; Mice; Mice, Inbred CBA; Organoselenium Compounds; Prostaglandins E; Selenium

1984
Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells.
    Free radical biology & medicine, 1993, Volume: 14, Issue:3

    Topics: Animals; Antioxidants; Azoles; Cell Survival; Free Radicals; Glutathione; Glutathione Peroxidase; Isoindoles; Leukemia L1210; Lipid Peroxidation; Mice; Organoselenium Compounds; Peroxides; Selenium; tert-Butylhydroperoxide; Tumor Cells, Cultured

1993
Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions.
    Journal of lipid research, 1993, Volume: 34, Issue:3

    Topics: Animals; Antioxidants; Aorta, Thoracic; Azoles; Buthionine Sulfoximine; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Iron; Isoindoles; Lipid Peroxides; Lipoproteins, LDL; Methionine Sulfoximine; Organoselenium Compounds; Oxidation-Reduction; Peroxides; Phenols; Photochemistry; Selenium; tert-Butylhydroperoxide

1993
The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistance/susceptibility.
    The Journal of biological chemistry, 1996, Mar-15, Volume: 271, Issue:11

    Topics: Antineoplastic Agents; Antioxidants; Azoles; Catalase; Cell Death; Drug Resistance; Female; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Isoindoles; Macrophage Activation; Models, Biological; Molsidomine; Nitric Oxide; Organoselenium Compounds; Selenium; Superoxide Dismutase; Tumor Cells, Cultured

1996
A bis-cyclodextrin diselenide with glutathione peroxidase-like activity.
    Biochimica et biophysica acta, 2000, Sep-29, Volume: 1481, Issue:2

    Topics: Animals; Antioxidants; Azoles; Catalysis; Cyclodextrins; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Kinetics; Liver; Molecular Structure; Organoselenium Compounds; Oxidation-Reduction; Rabbits; Selenium; Substrate Specificity

2000
OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis.
    Journal of lipid research, 2001, Volume: 42, Issue:5

    Topics: Antioxidants; Azoles; Cell Line; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Humans; Immunoblotting; Isoindoles; Lipid Peroxides; Lipoproteins, LDL; Macrophages; Organoselenium Compounds; Oxidative Stress; Protein Subunits; Reactive Oxygen Species; Selenium; Time Factors

2001
Redox catalysts as sensitisers towards oxidative stress.
    FEBS letters, 2003, Jan-30, Volume: 535, Issue:1-3

    Topics: Animals; Antioxidants; Azoles; Catalysis; Cell Survival; Chalcogens; Dose-Response Relationship, Drug; Drug Synergism; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Organometallic Compounds; Organoselenium Compounds; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Reactive Oxygen Species; Selenium; Sp1 Transcription Factor; Tellurium; Zinc Fingers

2003
Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia.
    European journal of pharmacology, 2004, Jul-08, Volume: 495, Issue:1

    Topics: Administration, Oral; Animals; Azoles; Body Weight; Brain; Brain Chemistry; Brain Ischemia; Drug Administration Schedule; Drug Evaluation, Preclinical; Glutathione; Infarction, Middle Cerebral Artery; Isoindoles; Male; Organoselenium Compounds; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion; Selenium; Spain; Time Factors

2004
Effect of selenium compounds on the damage induced by oxysterol on rat arterial walls.
    Biological trace element research, 2006, Volume: 112, Issue:3

    Topics: Animals; Arteries; Azoles; Cholesterol; Endothelium, Vascular; Isoindoles; Lipid Peroxides; Male; Microscopy, Electron, Scanning; Organoselenium Compounds; Rats; Rats, Wistar; Selenium; Selenium Compounds

2006
Oral pretreatment with ebselen enhances heat shock protein 72 expression and reduces myocardial infarct size.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:11

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Antioxidants; Azoles; Benzhydryl Compounds; Cells, Cultured; Deoxyguanosine; Gene Expression; Glutathione; HSP72 Heat-Shock Proteins; Hydrogen Peroxide; In Vitro Techniques; Isoindoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Organoselenium Compounds; Oxidative Stress; Pyrrolidinones; Rabbits; Rats; Rats, Sprague-Dawley; Selenium; Tetrazolium Salts; Thiazoles

2006
Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
    Journal of neuroscience research, 2008, Feb-15, Volume: 86, Issue:3

    Topics: Animals; Antioxidants; Azoles; Butadienes; Carbazoles; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Indole Alkaloids; Isoindoles; Mitogen-Activated Protein Kinases; Neurites; Neurofilament Proteins; Nitriles; Organoselenium Compounds; Oxidation-Reduction; PC12 Cells; Pertussis Toxin; Phosphorylation; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Selenium; Tyrphostins

2008
Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.
    Brain research, 2008, Jul-24, Volume: 1221

    Topics: Adenosine Triphosphatases; Animals; Antioxidants; Azoles; Brain Damage, Chronic; Cells, Cultured; Cerebellum; Chromans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Glutamic Acid; Isoindoles; Nerve Degeneration; Neurons; Neuroprotective Agents; Nucleotides; Organoselenium Compounds; Oxidative Stress; Rats; Selenium

2008
Synthesis of telluroamino acid derivatives with remarkable GPx like activity.
    Organic & biomolecular chemistry, 2009, Jan-07, Volume: 7, Issue:1

    Topics: Amino Acids; Antioxidants; Azoles; Catalysis; Chemistry; Chemistry, Pharmaceutical; Drug Design; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Models, Chemical; Organoselenium Compounds; Selenium

2009
Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
    Chemical communications (Cambridge, England), 2009, Nov-14, Issue:42

    Topics: Azoles; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Disulfiram; Isoindoles; Jumonji Domain-Containing Histone Demethylases; Organoselenium Compounds; Selenium; Spectrometry, Mass, Electrospray Ionization; Zinc

2009
Crucial role of selenium in the virucidal activity of benzisoselenazol-3(2H)-ones and related diselenides.
    Molecules (Basel, Switzerland), 2010, Nov-12, Volume: 15, Issue:11

    Topics: Antiviral Agents; Azoles; Cell Line, Tumor; Humans; Isoindoles; Magnetic Resonance Spectroscopy; Molecular Structure; Organoselenium Compounds; Selenium; Structure-Activity Relationship; Sulfur Compounds; Viruses

2010
Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.
    The Journal of biological chemistry, 2011, Feb-25, Volume: 286, Issue:8

    Topics: Animals; Antioxidants; Azoles; Cell Line; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Isoindoles; Methylmercury Compounds; Organoselenium Compounds; Oxidative Stress; Rats; RNA Stability; RNA, Messenger; Selenium; Selenoproteins; Thioredoxin Reductase 1

2011
Carboxyl-ebselen-based layer-by-layer films as potential antithrombotic and antimicrobial coatings.
    Biomaterials, 2011, Volume: 32, Issue:31

    Topics: Animals; Anti-Infective Agents; Antithrombins; Azoles; Catalysis; Coated Materials, Biocompatible; Cross-Linking Reagents; Escherichia coli; Free Radical Scavengers; Isoindoles; Microbial Sensitivity Tests; Microbial Viability; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Nitric Oxide; Organoselenium Compounds; Polyethyleneimine; S-Nitrosothiols; Selenium; Sheep; Spectrophotometry, Ultraviolet; Superoxides

2011
Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets.
    Antioxidants & redox signaling, 2014, Jan-10, Volume: 20, Issue:2

    Topics: Animals; Azoles; Glucokinase; Glucose; Glucose Tolerance Test; Glucose Transporter Type 2; Glutathione Peroxidase; Glutathione Reductase; Homeodomain Proteins; Hydro-Lyases; Insulin; Insulin Secretion; Ion Channels; Islets of Langerhans; Isoindoles; Male; Mice; Mice, Knockout; Mitochondrial Proteins; Molecular Mimicry; Organoselenium Compounds; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Selenium; Signal Transduction; Superoxide Dismutase; Trans-Activators; Transcription Factors; Uncoupling Protein 2

2014
Pyridoxine-derived organoselenium compounds with glutathione peroxidase-like and chain-breaking antioxidant activity.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2014, Sep-22, Volume: 20, Issue:39

    Topics: Antioxidants; Azoles; Biomimetic Materials; Carboxylic Acids; Crystallography, X-Ray; Glutathione Peroxidase; Hydrogen Peroxide; Isoindoles; Lipid Peroxidation; Models, Molecular; Organoselenium Compounds; Oxidation-Reduction; Pyridoxine; Selenium; Selenium Compounds

2014
Unusually short chalcogen bonds involving organoselenium: insights into the Se-N bond cleavage mechanism of the antioxidant ebselen and analogues.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Apr-27, Volume: 21, Issue:18

    Topics: Antioxidants; Azoles; Crystallography, X-Ray; Isoindoles; Models, Molecular; Molecular Structure; Nitrogen; Organoselenium Compounds; Selenium; Spectroscopy, Fourier Transform Infrared; Static Electricity

2015
Effect of a Bromo Substituent on the Glutathione Peroxidase Activity of a Pyridoxine-like Diselenide.
    The Journal of organic chemistry, 2015, Aug-07, Volume: 80, Issue:15

    Topics: Azoles; Bromine; Crystallography, X-Ray; Glutathione Peroxidase; Isoindoles; Magnetic Resonance Spectroscopy; Molecular Conformation; Organoselenium Compounds; Oxidation-Reduction; Pyridoxine; Selenium

2015
Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation.
    Dalton transactions (Cambridge, England : 2003), 2015, Dec-28, Volume: 44, Issue:48

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Azoles; Biocompatible Materials; Blood-Brain Barrier; Catalysis; Chelating Agents; Clioquinol; Glutathione Peroxidase; Hydroxyquinolines; Isoindoles; Magnetic Resonance Spectroscopy; Metals; Mice; Organoselenium Compounds; Selenium

2015
Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.
    Inflammation, 2016, Volume: 39, Issue:4

    Topics: Animals; Azoles; Cardiopulmonary Bypass; Dietary Supplements; Hypothermia, Induced; Inflammation; Isoindoles; Leukocytosis; Male; Organoselenium Compounds; Organs at Risk; Phosphorylation; Pre-Exposure Prophylaxis; Rats; Rats, Wistar; Reperfusion Injury; Selenium

2016
Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Arthritis, Experimental; Awards and Prizes; Azoles; Fatty Acids; Humans; Immunologic Factors; Inflammation; Isoindoles; Mice, Knockout; Organoselenium Compounds; Prostaglandins E, Synthetic; Rats; Reactive Oxygen Species; Selenium

2017
A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease.
    Journal of psychiatric research, 2019, Volume: 109

    Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Azoles; Disease Models, Animal; Isoindoles; Male; Memory Disorders; Mice; Neuroprotective Agents; Organoselenium Compounds; Oxidative Stress; Selenium

2019
A role for selenium-dependent GPX1 in SARS-CoV-2 virulence.
    The American journal of clinical nutrition, 2020, 08-01, Volume: 112, Issue:2

    Topics: Azoles; Betacoronavirus; Coronavirus Infections; COVID-19; Glutathione Peroxidase; Humans; Isoindoles; Nutritional Status; Organoselenium Compounds; Pandemics; Pneumonia, Viral; SARS-CoV-2; Selenium; Virulence; Virus Replication

2020
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Jul-05, Volume: 219

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Antioxidants; Aspartic Acid Endopeptidases; Azoles; Binding Sites; Blood-Brain Barrier; Cyclic S-Oxides; Drug Design; Humans; Interleukin-6; Isoindoles; Ligands; Mitochondria; Molecular Docking Simulation; Neuroprotective Agents; NF-E2-Related Factor 2; Organoselenium Compounds; Oxidative Stress; Peptide Fragments; Reactive Oxygen Species; Selenium; Signal Transduction; Thiadiazines

2021
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.
    Nature communications, 2021, 05-24, Volume: 12, Issue:1

    Topics: Antiviral Agents; Azoles; Catalytic Domain; Coronavirus 3C Proteases; Crystallography, X-Ray; Cysteine; Hydrolysis; Isoindoles; Models, Molecular; Organoselenium Compounds; Protease Inhibitors; Reference Standards; Salicylanilides; SARS-CoV-2; Selenium

2021
Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia-Reperfusion Injury in Rats and Ebselen Intervention Effects.
    Biological trace element research, 2023, Volume: 201, Issue:4

    Topics: Animals; Kidney; Mammals; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Selenium; Selenoprotein P; Selenoproteins; Thioredoxin Reductase 2

2023
Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues.
    Free radical biology & medicine, 2023, 11-01, Volume: 208

    Topics: Animals; Diquat; Fatty Acid Elongases; Glutathione Peroxidase; Glutathione Peroxidase GPX1; HEK293 Cells; Humans; Infant; Liver; Male; Mice; Mice, Knockout; RNA, Messenger; Selenium

2023