selegiline has been researched along with desmethylselegiline in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (43.59) | 18.2507 |
| 2000's | 20 (51.28) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castagnoli, K; Castagnoli, N; Flaherty, P; Wang, YX | 1 |
| Chorev, M; Finberg, J; Finkelstein, N; Friedman, R; Goldenberg, W; Goren, T; Gross, A; Herzig, Y; Huang, W; Krais, B; Lavian, G; Lerner, D; Miskolczi, I; Molnar, S; Rantal, F; Razin, M; Sterling, J; Tamas, T; Toth, G; Weinstock, M; Youdim, MB; Zagyva, A; Zekany, A | 1 |
| Borbe, HO; Nickel, B; Niebch, G | 1 |
| Borbe, HO; Nickel, B; Szelenyi, I | 1 |
| Mahmood, I; Mason, WD; Neau, SH | 1 |
| Gaál, J; Lengyel, J; Magyar, K; Szatmári, I; Szebeni, G; Székács, G | 1 |
| Bosc, M; Deffond, D; Dordain, G; Dostert, P; Fiorentini, F; La Croix, R; Persiani, S; Strolin Benedetti, M; Vernay, D | 1 |
| Ludwig, G; Michaelis, K; Pabst, G; Reh, C; Waitzinger, J | 1 |
| Barrett, JS; De Witt, KE; Ireland, J; Morales, RJ; Rajewski, G; Rohatagi, S; Szego, P | 1 |
| Kikuta, C; Ludwig, G; Mascher, HJ; Millendorfer, A; Schiel, H | 1 |
| Anttila, MI; Heinonen, EH; Karnani, HL; Lammintausta, RA; Nyman, LM; Pyykkö, KA; Vuorinen, JA | 1 |
| Barrett, JS; DeWitt, KE; Morales, RJ; Rohatagi, S | 1 |
| Barrett, JS; DeWitt, KE; Lessard, D; Morales, RJ; Rohatagi, S | 1 |
| Cohen, G; Han, SK; Heinonen, EH; Leonardi, EK; Mytilineou, C; Olanow, CW; Radcliffe, P; Werner, P | 1 |
| Anttila, M; Bertilsson, L; Dahl, ML; Karnani, H; Nyman, L; Pelkonen, O; Scheinin, H; Taavitsainen, P | 1 |
| Anttila, M; Helminen, A; Huupponen, R; Karnani, H; Laine, K | 1 |
| Fukushima, S; Hasegawa, M; Kimura, K; Maseda, C; Matsubara, K; Uezono, T | 1 |
| Borden, KE; Carlile, GW; Chalmers-Redman, RM; Pong, A; Tatton, NA; Tatton, WG | 1 |
| Maruyama, W; Naoi, M | 1 |
| Felten, DL; Madden, KS; Stevens, SY; ThyagaRajan, S | 1 |
| Anttila, M; Karnani, H; Nyman, L; Pelkonen, O; Salonen, JS; Taavitsainen, P | 1 |
| Hayashi, K; Kuno, S; Mizuta, E; Mizuta, I; Nishimura, M; Ohta, K; Ohta, M | 1 |
| Magyar, K; Szegedi, Z; Szende, B | 1 |
| Anttila, M; Backman, JT; Kivistö, KT; Neuvonen, PJ; Nyman, L; Taavitsainen, P; Wang, JS | 1 |
| Anttila, M; Bertilsson, L; Laine, K; Nyman, L; Wahlberg, A | 1 |
| Felten, DL; ThyagaRajan, S | 1 |
| Anttila, M; Laine, K; Nyman, L; Palovaara, S | 1 |
| Kamata, T; Katagi, M; Miki, A; Nakajima, K; Nishikawa, M; Nishioka, H; Tatsuno, M; Tsuchihashi, H; Tsutsumi, H | 1 |
| Foltz, RL; Moody, DE; Slawson, MH; Taccogno, JL | 1 |
| Akaike, A; Honda, Y; Kashii, S; Katsuki, H; Kobayashi, Y; Kume, T; Muraoka, S; Takahata, K; Yoneda, F | 1 |
| Agid, Y; Olanow, CW; Schapira, AH | 1 |
| Ahlner, J; Dizdar, N; Kronstrand, R; Larson, G | 1 |
| Ikeda, N; Inoue, N; Itoh, S; Kudo, K; Nishida, K | 1 |
| Hasegawa, C; Kawamura, M; Kumazawa, T; Kuriki, A; Lee, XP; Sato, K; Suzuki, O | 1 |
| Alok, R; Benetton, SA; Fang, C; Lin, CC; Yang, YO; Year, M; Yeh, LT | 1 |
| Lengyel, J; Magyar, K; Szatmáry, I; Szebeni, G | 1 |
| Everhart, T; Harris, DS; Jacob, P; Jones, RT; Lin, E; Mendelson, JE | 1 |
| Barna, G; Magyar, K; Szende, B | 1 |
| Chen, L; Duan, G; Shen, B; Shi, Y; Wang, S; Xiang, P; Yan, H; Yu, Y | 1 |
1 review(s) available for selegiline and desmethylselegiline
| Article | Year |
|---|---|
Modulation of neuroendocrine--immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer.
Topics: Aging; Amphetamines; Animals; Cardiovascular System; Humans; Immune System; Lymphoid Tissue; Mammary Neoplasms, Animal; Neuroimmunomodulation; Neuroprotective Agents; Neurosecretory Systems; Selegiline; Signal Transduction | 2002 |
12 trial(s) available for selegiline and desmethylselegiline
| Article | Year |
|---|---|
Lack of pharmacokinetic interaction between the selective dopamine agonist cabergoline and the MAO-B inhibitor selegiline.
Topics: Aged; Amphetamine; Amphetamines; Antiparkinson Agents; Cabergoline; Dopamine Agonists; Drug Interactions; Ergolines; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline | 1995 |
Bioequivalence evaluation of two preparations containing the highly variable compound selegiline (L-deprenyl).
Topics: Administration, Oral; Adult; Amphetamines; Analysis of Variance; Antiparkinson Agents; Biological Availability; Cross-Over Studies; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Selegiline; Therapeutic Equivalency | 1996 |
Desmethylselegiline, a metabolite of selegiline, is an irreversible inhibitor of monoamine oxidase type B in humans.
Topics: Adolescent; Adult; Amphetamines; Antiparkinson Agents; Blood Platelets; Blood Pressure; Cross-Over Studies; Double-Blind Method; Female; Heart Rate; Humans; Male; Middle Aged; Monoamine Oxidase Inhibitors; Phenethylamines; Selegiline | 1997 |
Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration.
Topics: Administration, Cutaneous; Amphetamine; Amphetamines; Antiparkinson Agents; Area Under Curve; Humans; Male; Methamphetamine; Models, Biological; Monoamine Oxidase Inhibitors; Pilot Projects; Regression Analysis; Selegiline | 1997 |
Pharmacokinetic evaluation of a selegiline pulsatile oral delivery system.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Area Under Curve; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Delivery Systems; Humans; Intestinal Absorption; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Pilot Projects; Reference Values; Selegiline; Therapeutic Equivalency; Time Factors | 1997 |
CYP2D6 polymorphism is not crucial for the disposition of selegiline.
Topics: Adrenergic Agents; Adult; Amphetamines; Area Under Curve; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Humans; In Vitro Techniques; Male; Methamphetamine; Microsomes, Liver; Monoamine Oxidase Inhibitors; Polymorphism, Genetic; Reference Values; Selegiline | 1998 |
Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids.
Topics: Administration, Oral; Adult; Amphetamines; Antiparkinson Agents; Area Under Curve; Contraceptive Agents, Female; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Selegiline | 1999 |
Selegiline pharmacokinetics are unaffected by the CYP3A4 inhibitor itraconazole.
Topics: Adult; Amphetamines; Antifungal Agents; Area Under Curve; Central Nervous System Stimulants; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Itraconazole; Male; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Selegiline; Statistics, Nonparametric | 2001 |
CYP2C19 polymorphism is not important for the in vivo metabolism of selegiline.
Topics: Adult; Amphetamines; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Phenotype; Polymorphism, Genetic; Selegiline | 2001 |
Effect of concomitant hormone replacement therapy containing estradiol and levonorgestrel on the pharmacokinetics of selegiline.
Topics: Administration, Oral; Adult; Amphetamines; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Interactions; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Female; Humans; Levonorgestrel; Methamphetamine; Monoamine Oxidase Inhibitors; Progesterone Congeners; Selegiline | 2002 |
Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication.
Topics: Aged; Aged, 80 and over; Amphetamine; Amphetamines; Antiparkinson Agents; Drug Administration Schedule; Female; Hair; Hair Color; Humans; Male; Melanins; Methamphetamine; Middle Aged; Parkinson Disease; Patient Compliance; Selegiline; Spectrophotometry | 2003 |
A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.
Topics: Administration, Cutaneous; Adult; Affect; Amphetamine; Amphetamines; Analysis of Variance; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Female; Homovanillic Acid; Humans; Infusions, Intravenous; Male; Methamphetamine; Methoxyhydroxyphenylglycol; Monitoring, Physiologic; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Prolactin; Selegiline; Statistics, Nonparametric; Substance Withdrawal Syndrome; Young Adult | 2009 |
26 other study(ies) available for selegiline and desmethylselegiline
| Article | Year |
|---|---|
Synthesis and selective monoamine oxidase B-inhibiting properties of 1-methyl-1,2,3,6-tetrahydropyrid-4-yl carbamate derivatives: potential prodrugs of (R)- and (S)-nordeprenyl.
Topics: Animals; Brain; Carbamates; Enzyme Inhibitors; Humans; Kinetics; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Mitochondria; Molecular Conformation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Placenta; Prodrugs; Pyridines; Substrate Specificity | 1996 |
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Carbamates; Cattle; Cholinesterase Inhibitors; Humans; Indans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Propylamines; Structure-Activity Relationship | 2002 |
Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat.
Topics: Administration, Oral; Amphetamines; Animals; Clorgyline; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Monoamine Oxidase; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Effect of selegiline and desmethyl-selegiline on cortical electric activity in rats.
Topics: Amphetamines; Animals; Cerebral Cortex; Electroencephalography; Female; Fourier Analysis; Rats; Rats, Inbred Strains; Selegiline | 1990 |
An enzymatic assay for the MAO-B inhibitor selegiline in plasma.
Topics: Amphetamine; Amphetamines; Animals; Brain; Humans; Hydroxyquinolines; Male; Methamphetamine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Spectrometry, Fluorescence | 1994 |
Gas chromatographic procedure for simultaneous determination of selegiline metabolites, amphetamine, methamphetamine and demethyl-deprenyl in pig plasma.
Topics: Amphetamine; Amphetamines; Animals; Capsules; Central Nervous System Stimulants; Chromatography, Gas; Female; Indicators and Reagents; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Swine; Tablets | 1995 |
Absorption and presystemic metabolism of selegiline hydrochloride at different regions in the gastrointestinal tract in healthy males.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Biological Availability; Cross-Over Studies; Duodenum; Gastric Mucosa; Humans; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline | 1996 |
Pharmacokinetics and bioequivalence of the main metabolites of selegiline: desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Biological Availability; Central Nervous System Stimulants; Half-Life; Humans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Therapeutic Equivalency | 1997 |
Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion.
Topics: Amphetamines; Animals; Ascorbic Acid; Buthionine Sulfoximine; Cells, Cultured; Dose-Response Relationship, Drug; Glutathione; Mazindol; Mesencephalon; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Pargyline; Rats; Selegiline; Tyrosine 3-Monooxygenase | 1998 |
Stereoselective analyses of selegiline metabolites: possible urinary markers for selegiline therapy.
Topics: Adult; Amphetamine; Amphetamines; Biomarkers; Chromatography, Gas; Diagnosis, Differential; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Selegiline; Stereoisomerism; Substance Abuse Detection; Substance-Related Disorders | 1999 |
Reduced apoptosis after nerve growth factor and serum withdrawal: conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer.
Topics: Amphetamines; Animals; Apoptosis; Blood Proteins; Dimerization; Glyceraldehyde-3-Phosphate Dehydrogenases; Monoamine Oxidase Inhibitors; Nerve Growth Factor; Oxepins; PC12 Cells; Protein Conformation; Rats; Selegiline | 2000 |
Neuroprotection by (-)-deprenyl and related compounds.
Topics: Aging; Amphetamines; Animals; Antioxidants; Apoptosis; Cattle; DNA Damage; DNA, Neoplasm; Indans; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Nitrates; Oxidants; Parkinson Disease; Selegiline; Tumor Cells, Cultured | 1999 |
Restoration of splenic noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-deprenyl and L-desmethyldeprenyl.
Topics: Adrenergic Fibers; Aging; Amphetamines; Animals; Male; Nerve Regeneration; Norepinephrine; Rats; Rats, Inbred F344; Selegiline; Spleen | 2000 |
Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes.
Topics: Amphetamines; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Ketoconazole; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Selegiline; Theophylline | 2000 |
Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes.
Topics: Amphetamines; Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cells, Cultured; Glial Cell Line-Derived Neurotrophic Factor; Mice; Mice, Inbred ICR; Monoamine Oxidase Inhibitors; Nerve Growth Factor; Nerve Growth Factors; Nerve Tissue Proteins; Selegiline | 2000 |
Apoptotic and antiapoptotic effect of (-)deprenyl and (-)-desmethyl-deprenyl on human cell lines.
Topics: Amphetamines; Animals; Apoptosis; Humans; Male; Mice; Mice, Inbred CBA; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Selegiline; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Urinary excretion of selegiline N-oxide, a new indicator for selegiline administration in man.
Topics: Adrenergic Uptake Inhibitors; Adult; Amphetamine; Amphetamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Methamphetamine; Models, Chemical; Monoamine Oxidase Inhibitors; Selegiline; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2002 |
Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in human plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Topics: Amphetamine; Amphetamines; Chromatography, High Pressure Liquid; Freezing; Humans; Mass Spectrometry; Methamphetamine; Monoamine Oxidase Inhibitors; Reproducibility of Results; Selegiline | 2002 |
Protective effects of selegiline and desmethylselegiline against N-methyl-D-aspartate-induced rat retinal damage.
Topics: Amphetamines; Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; Injections; Injections, Subcutaneous; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Selegiline; Superior Colliculi; Vitreous Body | 2003 |
Neuroprotection for Parkinson's disease: prospects and promises.
Topics: Amphetamines; Clinical Trials as Topic; Glial Cell Line-Derived Neurotrophic Factor; Humans; Monoamine Oxidase Inhibitors; Nerve Growth Factors; Neuroprotective Agents; Parkinson Disease; Selegiline | 2003 |
High-performance liquid chromatographic-mass spectrometric determination of methamphetamine and amphetamine enantiomers, desmethylselegiline and selegiline, in hair samples of long-term methamphetamine abusers or selegiline users.
Topics: Amphetamine; Amphetamines; Antiparkinson Agents; Chromatography, High Pressure Liquid; Hair; Humans; Methamphetamine; Parkinson Disease; Selegiline; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection | 2006 |
Simultaneous determination of selegiline and desmethylselegiline in human body fluids by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Amphetamines; Body Fluids; Gas Chromatography-Mass Spectrometry; Humans; Molecular Structure; Reproducibility of Results; Selegiline; Solid Phase Microextraction | 2006 |
P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine.
Topics: Amphetamines; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Monoamine Oxidase Inhibitors; Oxidoreductases, N-Demethylating; Phenotype; Recombinant Proteins; Selegiline; Tandem Mass Spectrometry | 2007 |
Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse.
Topics: Administration, Oral; Amphetamine; Amphetamines; Animals; Antiparkinson Agents; Biological Availability; Biotransformation; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Metabolic Clearance Rate; Methamphetamine; Mice; Mice, Inbred Strains; Monoamine Oxidase Inhibitors; Selegiline | 2007 |
Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells.
Topics: Amphetamines; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Cytoprotection; Drug Interactions; Flow Cytometry; Glutathione; Humans; Melanoma; Monoamine Oxidase Inhibitors; Radiation-Sensitizing Agents; Selegiline; Serum | 2010 |
Pharmacokinetics of selegiline, R-methamphetamine, R-amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline.
Topics: Administration, Oral; Amphetamine; Amphetamines; Humans; Liquid-Liquid Extraction; Methamphetamine; Monoamine Oxidase Inhibitors; Saliva; Selegiline; Substance Abuse Detection | 2019 |