selegiline has been researched along with clorgyline in 420 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 208 (49.52) | 18.7374 |
| 1990's | 95 (22.62) | 18.2507 |
| 2000's | 48 (11.43) | 29.6817 |
| 2010's | 61 (14.52) | 24.3611 |
| 2020's | 8 (1.90) | 2.80 |
| Authors | Studies |
|---|---|
| Ask, AL; Claesson, A; Fagervall, I; Ross, SB; Sahlberg, C | 1 |
| Burstein, C; Gueddari, S; Mansuy, D; Mazouz, F; Milcent, R | 1 |
| Agostinelli, E; Artico, M; Befani, O; De Martino, G; La Regina, G; Palumbo, M; Silvestri, R; Turini, P | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Agostinelli, E; Artico, M; Befani, O; La Regina, G; Lavecchia, A; Novellino, E; Silvestri, R; Turini, P | 1 |
| Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X | 1 |
| Alcaro, S; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Cirilli, R; Ferretti, R; Granese, A; La Torre, F; Maccioni, E; Orallo, F; Ortuso, F; Secci, D; Yáñez, M | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Agostinelli, E; Befani, O; Gatti, V; La Regina, G; Lavecchia, A; Novellino, E; Silvestri, R; Turini, P | 1 |
| Ercan, A; Jayaprakash, V; Sinha, BN; Ucar, G | 1 |
| Erol, K; Gökhan-Kelekçi, N; Kendi, E; Koyunoğlu, S; Ozgen, O; Uçar, G; Yabanoğlu, S; Yelekçi, K; Yeşilada, A | 1 |
| Alcaro, S; Bizzarri, B; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Granese, A; Orallo, F; Ortuso, F; Secci, D; Yáñez, M | 1 |
| Alcaro, S; Bolasco, A; Chimenti, F; Chimenti, P; Fioravanti, R; Orallo, F; Ortuso, F; Rossi, F; Secci, D; Yáñez, M | 1 |
| Bizzarri, B; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Granese, A; Orallo, F; Secci, D; Yáñez, M | 1 |
| Alcaro, S; Bolasco, A; Chimenti, F; Chimenti, P; Cirilli, R; Ferretti, R; Fioravanti, R; Orallo, F; Ortuso, F; Rossi, F; Sanna, ML; Secci, D; Yáñez, M | 1 |
| Alcaro, S; Borges, F; Gaspar, A; Milhazes, N; Orallo, F; Ortuso, F; Uriarte, E; Yáñez, M | 1 |
| Alcaro, S; Bolasco, A; Cardia, MC; Carradori, S; Chimenti, F; Chimenti, P; Cirilli, R; Distinto, S; Ferretti, R; Granese, A; Kirchmair, J; Langer, T; Maccioni, E; Orallo, F; Ortuso, F; Secci, D; Yáñez, M | 1 |
| Alcaro, S; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Granese, A; Orallo, F; Ortuso, F; Secci, D; Yáñez, M | 1 |
| Alcaro, S; Cardia, MC; Costa, G; Distinto, S; Maccioni, E; Meleddu, R; Orallo, F; Sanna, ML; Secci, D; Vigo, S; Yanez, M | 1 |
| Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Cirilli, R; Gallinella, B; Granese, A; Orallo, F; Sanna, ML; Secci, D; Yáñez, M | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Alcaro, S; Bolasco, A; Fioravanti, R; Manna, F; Orallo, F; Ortuso, F; Rossi, F; Vitali, A; Yáñez, M | 1 |
| Alcaro, S; Bolasco, A; Desideri, N; Fioravanti, R; Monaco, LP; Orallo, F; Ortuso, F; Yáñez, M | 1 |
| Alcaro, S; Bolasco, A; Carradori, S; Chimenti, P; Ortuso, F; Secci, D; Yáñez, M | 1 |
| Gulyás, B; Halldin, C; Heinrich, T; Kettschau, G; Lehmann, L; Nag, S; Nakao, R; Thiele, A | 1 |
| Escobar, M; García-Mera, X; González-Díaz, H; Prado-Prado, F; Riera-Fernandez, P; Sobarzo-Sánchez, E; Yañez, M | 1 |
| Alcaro, S; Bolasco, A; Cardia, MC; Distinto, S; Gaspari, M; Kirchmair, J; Maccioni, E; Markt, P; Meleddu, R; Ortuso, F; Sanna, ML; Secci, D; Wolber, G; Yáñez, M | 1 |
| Bai, L; Guo, DH; Guo, YS; Liu, P; Mu, LH; Ren, HY; Wang, B; Wang, FM | 1 |
| Bialonska, D; Chaurasiya, ND; Lewellyn, K; Tekwani, BL; Zjawiony, JK | 1 |
| Huang, L; Jiang, H; Li, X; Lu, C; Luo, Z; Mao, F; Shan, W; Su, T; Sun, Y | 1 |
| Lourens, AC; Petzer, A; Petzer, JP; Terre'Blanche, G; Van der Walt, MM | 1 |
| Abdalla, MM; Abdelhafez, OM; Ali, HI; Amin, KM; Batran, RZ | 1 |
| Bolasco, A; Carradori, S; D'Ascenzio, M; Nescatelli, R; Secci, D; Yáñez, M | 1 |
| Alcaro, S; Biava, M; Desideri, N; Fioravanti, R; Ortuso, F; Proietti Monaco, L; Yáñez, M | 2 |
| Bartoccini, F; Borsini, F; Cabri, W; Diamantini, G; Minetti, P; Mor, M; Pala, D; Piersanti, G; Riccioni, T; Rivara, S; Stasi, MA; Tarzia, G | 1 |
| Biava, M; Desideri, N; Fioravanti, R; Grammatica, L; Proietti Monaco, L; Yáñez, M | 1 |
| Agostinelli, E; Bonaiuto, E; Cozza, G; Di Paolo, ML; Fimognari, C; Hrelia, P; Marchetti, C; Milelli, A; Minarini, A; Tumiatti, V | 1 |
| Alcaro, S; Carradori, S; Cirilli, R; D'Ascenzio, M; De Monte, C; Mannina, L; Ortuso, F; Secci, D; Sobolev, AP; Yáñez, M | 1 |
| Bautista-Aguilera, OM; Esteban, G; Fernández Fernández, AP; Herrero, R; Inokuchi, T; Iriepa, I; Marco-Contelles, J; Moraleda, I; Ojima, M; Romero, A; Samadi, A; Soriano, E; Unzeta, M; Wang, L; Youdim, MB | 1 |
| Agbaba, D; Alcaro, S; Bautista-Aguilera, OM; Chioua, M; de Andrés, L; Filipic, S; Marco-Contelles, J; Nikolic, K; Ortuso, F; Ramsay, RR; Rodríguez-Franco, MI; Samadi, A; Soriano, E; Yañez, M | 1 |
| Chen, R; Han, Y; Liu, XH; Tang, WJ; Tong, X; Zhang, TT | 1 |
| Almos, T; Edmondson, DE; Massari, ME; Rojas, RJ; Scott, R | 1 |
| Chen, J; Huang, L; Li, X; Su, T; Wang, Y; Wang, Z; Xie, S | 1 |
| Adolph, O; Appenroth, D; Enzensperger, C; Fleck, C; Föhr, KJ; Gaube, F; Lehmann, J; Otto, R; Penzis, R; Robaa, D; Warncke, P; Winckler, T | 1 |
| Cho, NC; Choi, JW; Han, G; Jang, BK; Ju, EJ; Kim, DJ; Lee, YS; Pae, AN; Park, JH; Park, KD; Yeon, SK | 1 |
| Cheng, HJ; Guo, LL; Li, HL; Liao, C; Ren, J; Ruan, BF; Zhang, XX | 1 |
| Brogi, S; Butini, S; Campiani, G; Esteban, G; Inokuchi, T; Marco-Contelles, J; Shionoya, M; Unzeta, M; Wang, L; Wu, MY | 1 |
| Chen, R; Liao, C; Ni, Y; Tang, WJ; Tong, X; Xiao, J; Xu, HF; Zhang, TT; Zheng, M | 1 |
| Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E | 1 |
| Foka, GB; Joubert, J; Kapp, E; Malan, SF; Oliver, DW; Repsold, BP | 1 |
| Baysal, M; Can, ÖD; Demir Özkay, Ü; Ilgın, S; Kaplancıklı, ZA; Levent, S; Osmaniye, D; Özkay, Y; Sağlık, BN | 1 |
| Alcaro, S; Bagetta, D; Borges, F; Fonseca, A; Matos, MJ; Ortuso, F; Reis, J; Silva, T; Uriarte, E | 1 |
| Ding, LN; Duan, YC; Guan, YY; Ma, CY; Ma, YC; Qin, WP; Yang, J; Zhai, XY; Zheng, YC; Zhu, YL | 1 |
| Aktumsek, A; Alcaro, S; Bagetta, D; Carradori, S; De Monte, C; De Vita, D; Guglielmi, P; Ortuso, F; Petzer, A; Petzer, JP; Secci, D; Zengin, G | 1 |
| Bahn, YS; Choi, JW; Han, G; Jang, BK; Kim, HJ; Kim, S; Lee, YR; Lee, YS; Pae, AN; Park, JH; Park, KD; Shin, SJ; Yeon, SK | 1 |
| Buchwalder, C; Devineau, A; Dullaghan, EM; Gealageas, R; Goebeler, V; Grierson, DS; Heller, M; Kim, CMJ; Putnins, EE; So, PPL; Surendradoss, J | 1 |
| Borges, F; Delogu, GL; Fontenla, JA; Hripcsak, G; Matos, MJ; Mayán, L; Munín, J; Pintus, F; Vilar, S; Viña, D | 1 |
| Alcaro, S; Bagetta, D; Borges, F; Cagide, F; Oliveira, PJ; Ortuso, F; Pérez, C; Reis, J; Rodríguez-Franco, MI; Teixeira, J; Uriarte, E; Valencia, ME | 1 |
| Duan, Y; Guan, Y; Liu, H; Qin, W; Suo, F; Wang, X; Zhai, X; Zheng, Y | 1 |
| Ekpo, OE; Enogieru, AB; Joubert, J; Malan, SF; Omoruyi, SI; Zindo, FT | 1 |
| Cheng, K; Duan, Y; Han, J; Huang, X; Kong, H; Li, S; Liao, C; Lv, X; Tian, Y; Xie, Z | 2 |
| Borges, F; Chavarria, D; Fernandes, C; Gil-Martins, E; Oliveira, PJ; Remião, F; Silva, C; Silva, R; Silva, T; Silva, V; Soares, P | 1 |
| Chen, KZ; Hao, GF; Jin, CF; Wang, ZZ; Xu, TF | 1 |
| Acar Çevik, U; Kaplancıklı, ZA; Kaya Çavuşoğlu, B; Levent, S; Osmaniye, D; Özkay, Y; Sağlık, BN | 1 |
| Chen, ZT; Fu, YD; Guo, JW; Huang, LH; Huang, MJ; Li, R; Liu, HM; Song, TY; Xu, WY; You, YZ | 1 |
| Abu-Serie, MM; Amer, A; Awad, LF; Ayoup, MS; Ragab, HM; Teleb, M | 1 |
| Legoabe, LJ; Meiring, L; Petzer, A; Petzer, JP | 1 |
| Fuller, RW; Meyerson, LR | 1 |
| Bakhle, YS; Youdim, MB | 1 |
| Callingham, BA; Lyles, GA | 1 |
| Hattori, H; Katsumata, Y; Matsumoto, T; Oya, M; Suzuki, O | 1 |
| Prozialeck, WC; Vogel, WH | 1 |
| Baulu, J; Garrick, N; Murphy, DL; Redmond, DE | 1 |
| Lipper, S; Murphy, DL; Shiling, D; Slater, S | 1 |
| Egashira, T; Kamijo, K | 1 |
| Feldman, JM; Reintgen, DS; Seigler, HF | 1 |
| Ismahan, G; Parvez, H; Parvez, S; Youdim, MB | 1 |
| Frazer, A; Mendels, J; Savage, DD | 1 |
| Katsumata, Y; Matsumoto, T; Oya, M; Suzuki, O | 2 |
| Hattori, H; Katsumata, Y; Oya, M; Suzuki, O | 1 |
| Breakefield, XO; Castro Costa, MR | 1 |
| Domino, EF; Hough, LB | 1 |
| Kung, HC; Wilson, AG | 1 |
| Severina, IS | 2 |
| D'Iorio, A; Kandaswami, C; Tong, JH | 1 |
| Bégin-Heick, N; D'Iorio, A; Limson-Zamora, M; Tong, JH | 1 |
| Cross, AJ; Glover, V; Lofthouse, R; Owen, F | 1 |
| Lyles, GA; Shaffer, CJ | 1 |
| Achee, FM; Gabay, S | 1 |
| Felner, AE; Waldmeier, PC | 1 |
| Katsumata, Y; Matsumoto, I; Oya, M; Suzuki, O | 1 |
| Greenawalt, JW; Sawyer, ST | 1 |
| Detmer, K; Salach, JI; Youdim, MB | 1 |
| Katsumata, Y; Oya, M; Suzuki, O | 2 |
| Ekstedt, B | 1 |
| Aronson, M; Fabian, I | 1 |
| Boulton, AA; Philips, SR | 1 |
| Edwards, DJ | 1 |
| Clarke, DE; Dial, EJ | 1 |
| Egashira, T; Kamijo, K; Kuroiwa, Y | 1 |
| Youdim, MB | 3 |
| Asano, M; Katsumata, Y; Oya, M; Suzuki, O | 1 |
| Chiueh, CC; Huang, SJ; Murphy, DL | 2 |
| Kaakkola, S; Wurtman, RJ | 1 |
| Kuczenski, R; Okuda, C; Segal, DS | 1 |
| Nag, M; Nandi, N | 1 |
| Männistö, PT; Törnwall, M | 1 |
| Cabanillas, AM; Coleoni, AH; Masini-Repiso, AM | 2 |
| Buckman, TD | 1 |
| Itzhak, Y; Mash, D; Stein, I; Zhang, SH | 1 |
| Bielarczyk, H; Luszawska, D; Micossi, LG; Santarelli, I; Szutowicz, A; Tomaszewicz, M | 1 |
| Cohen, G; Werner, P | 1 |
| Murphy, DL; Newman, JD; Winslow, JT | 1 |
| Iwata, N; Kumagae, Y; Matsui, Y | 1 |
| Wagner, GC; Walsh, SL | 1 |
| Kosir, N; Pavlin, R; Vidmar, V | 1 |
| Delanney, LE; Di Monte, DA; Irwin, I; Langston, JW; Wu, EY | 1 |
| Kumagae, Y; Matsui, Y | 1 |
| Nicotra, A; Scopelliti, R; Senatori, O | 1 |
| Kinemuchi, H; Obata, T; Sho, S; Yamanaka, Y | 1 |
| Arbuthnott, GW; Butcher, SP; Fairbrother, IS; Kelly, JS | 1 |
| Azam, M; Baquer, NZ; Jain, S | 1 |
| Bhattacharya, SK; Datla, KP | 1 |
| Garrett, MC; Soares-da-Silva, P | 1 |
| Gershon, MD; Pintar, JE; Sherman, DL | 1 |
| Salach, JI; Titlow, CC; Weyler, W | 1 |
| Obata, T; Yamanaka, Y | 1 |
| Borbe, HO; Nickel, B; Niebch, G | 1 |
| Cohen, G | 1 |
| Balsa, D; Fernandez de Arriba, A; Tipton, KF; Unzeta, M | 1 |
| Clement, HW; Grote, C; Wesemann, W | 1 |
| Hess, A | 1 |
| Gramsbergen, JB; Korf, J; Sebens, JB | 1 |
| Marsden, CA; Martin, KF; Palfreyman, MG; Sleight, AJ | 1 |
| McCauley, R; McIntyre, I; Oxenkrug, G; Yuwiler, A | 1 |
| Amedro, JB; Azzaro, AJ; Brown, LM; Smith, DJ; Williams, GM | 1 |
| Anderson, MC; O'Carroll, AM; Phillips, JP; Tipton, KF; Tobbia, I | 1 |
| Banerjee, DK; Kelner, K; Offutt, L; Pollard, HB; Youdim, MB | 1 |
| Chen, CH; Lan, NC; Shih, JC | 1 |
| Arai, Y; Kim, SK; Kinemuchi, H; Kisara, K; Satoh, N; Satoh, S; Tadano, T | 1 |
| Balsa, MD; Gómez, N; Unzeta, M | 1 |
| Goldstein, DS; Hovevey-Sion, D; Kopin, IJ; Stull, RW | 1 |
| Akiguchi, I; Kameyama, M; Kamo, H; Kawamura, J; Maeda, T; Matsubayashi, K; Oka, N; Shigematsu, K | 1 |
| Orsulak, PJ; Szutowicz, A; Tomaszewicz, M | 1 |
| Bunag, RD; Kerecsen, L | 1 |
| Blinc, M; Dernovsek, M; Sket, D | 1 |
| Yu, PH | 2 |
| Chichester, CO; Kagan, HM; Tang, SS | 1 |
| Filipowicz, C; McCauley, R; McIntyre, IM; Oxenkrug, GF | 1 |
| Nicotra, A; Senatori, O | 2 |
| Fagervall, I; Ross, SB | 1 |
| Gudelsky, GA; Jackman, H; Koenig, JI; Meltzer, HY | 1 |
| Graham, D; Langer, SZ; Tahraoui, L | 1 |
| Finberg, JP; Tal, A | 1 |
| Blier, P; de Montigny, C | 1 |
| Cohen, RM; Garrick, NA; Murphy, DL; Sunderland, T; Tamarkin, L | 1 |
| Aono, T; Kimura, H; Maeda, T; Sakumoto, T; Tanizawa, O; Yoshimoto, Y | 1 |
| Delansorne, R; Dial, EJ; Huang, J; Lichtenberger, LM | 1 |
| Higashida, H; Kojima, K; Nagatsu, T; Nakano, T; Saito, S | 1 |
| Knoll, B; Timár, J | 1 |
| Heikkila, RE; Kindt, MV | 1 |
| Bey, P; Danzin, C; Fozard, JR; Lyles, GA; McDonald, IA; Palfreyman, MG; Zreika, M | 1 |
| Hirokami, M; Minami, M; Parvez, H; Saito, H; Senjo, M; Yamazaki, N | 1 |
| Nagatsu, T; Naoi, M | 1 |
| Rényi, L | 1 |
| Aono, T; Arai, R; Kimura, H; Maeda, T; Miyake, A; Sakumoto, T; Tanizawa, O; Yoshimoto, Y | 1 |
| Farrell, MA; Hardiman, OM; McDonnell, L; Phillips, JP; Sullivan, JP; Tipton, KF | 1 |
| Inagaki, T; Rao, NA; Yagi, K | 1 |
| Commissaris, RL; Fontana, DJ; McCauley, RB; McIntyre, IM; Oxenkrug, GF | 1 |
| Bocchetta, A; Corsini, GU; Del Zompo, M; Piccardi, MP; Pintus, S | 2 |
| Arai, R; Jouvet, M; Kitahama, K; Maeda, T | 1 |
| Andrada, MC; Cabanillas, AM; Coleoni, AH; Masini-Repiso, AM | 1 |
| Ross, SB | 1 |
| Arnett, CD; Christman, D; Dewey, SL; Fowler, JS; Logan, J; MacGregor, RR; Sachs, H; Schlyer, D; Smith, M; Wolf, AP | 1 |
| Bizière, K; Kan, JP; Roncucci, R; Wermuth, CG; Worms, P | 1 |
| Bizière, K; Kan, JP; Mouget-Goniot, C; Steinberg, R; Worms, P | 1 |
| McCrodden, JM; Tipton, KF; Youdim, MB | 1 |
| Knoll, B; Knoll, J; Timar, J | 1 |
| Arnaldos, JD; Cremades, A; Milanés, MV; Vargas, ML | 1 |
| Bures, J; Buresová, O | 1 |
| Angers, M; Nguyen, TB | 1 |
| Amenta, F; Bonifati, V; Collier, WL; Meco, M; Ramacci, MT | 1 |
| Finberg, JP; Hovevey-Sion, D | 1 |
| Garrick, NA; Hill, JL; Murphy, DL; Tamarkin, L | 1 |
| Egashira, T; Obata, T; Yamanaka, Y | 1 |
| Graham, D; Langer, SZ | 1 |
| Harik, SI; Kalaria, RN | 1 |
| Nagatsu, T; Naoi, M; Shibahara, K; Suzuki, H; Takahashi, T | 1 |
| Egashira, T; Yamamoto, T; Yamanaka, Y | 4 |
| Nagatsu, T; Naoi, M; Takahashi, T | 1 |
| Yahr, MD | 1 |
| Egashira, T; Yamanaka, Y | 1 |
| Duvoisin, RC; Heikkila, RE; Kindt, MV; Sonsalla, PK; Youngster, SK | 1 |
| Bhattacharya, SK; Mukhopadhyay, M; Upadhyay, SN | 1 |
| Giovanni, A; Heikkila, RE; Kindt, MV; McKeown, KA; Singer, TP; Sonsalla, PK; Youngster, SK | 1 |
| Colasanti, BK | 1 |
| Grimm, LJ; Kellar, KJ; Kettler, KG; Perry, DC | 1 |
| Larsson, BS; Lindquist, NG; Lydén-Sokolowski, A | 1 |
| Dudley, MW | 1 |
| Marek, GJ; Seiden, LS | 1 |
| Greenshaw, AJ; Juorio, AV; Wishart, TB | 1 |
| Cesura, AM; Da Prada, M; Kettler, R; Richards, JG | 1 |
| Duvoisin, RC; Heikkila, RE; Hess, A | 1 |
| Caramona, MM; Osswald, W | 1 |
| Araújo, D; Brandão, F; Caramona, MM | 1 |
| Garratt, HM; Morinan, A | 1 |
| Donnelly, M; Ismond, D; Rapoport, JL; Zametkin, A | 1 |
| Finberg, JP; Youdim, MB | 1 |
| Azzaro, AJ; Frost, J; King, J; Kotzuk, J; Schochet, S; Schoepp, DD | 1 |
| Cabbat, FS; Duvoisin, RC; Heikkila, RE; Manzino, L | 2 |
| Alexoff, D; Arnett, CD; Fowler, JS; Halldin, C; Langström, B; MacGregor, RR; Wolf, AP | 1 |
| Salach, JI; Weyler, W | 1 |
| DuMontier, G; Jeng, I; Soblosky, JS | 1 |
| Marley, E; Wozniak, KM | 1 |
| de Montigny, C; Descarries, L; Ferron, A; Reader, TA | 1 |
| Carmichael, SW; Pfeiffer, GL | 1 |
| Fowler, CJ; Oreland, L | 1 |
| Browne, BJ; Callingham, BA; Lyles, GA; Parkinson, D | 1 |
| Callingham, BA; Fowler, CJ; Oreland, L | 1 |
| Kamijo, K; Kobayashi, S; Takahara, K | 1 |
| Fung, SC; Kong, YC; Lam, DM | 1 |
| de Vlaming, VL; Figueroa, HR; Hall, TR; Olcese, JM | 1 |
| Green, AL | 1 |
| deVlaming, VL; Figueroa, HR; Hall, TR; Olcese, JM | 1 |
| Hall, TR; Urueña, G | 2 |
| Boucher, T; Dostert, P; Dow, J; Strolin Benedetti, M | 1 |
| Fowler, CJ; Tipton, KF | 1 |
| Kobayashi, S; Oguchi, K; Yamamoto, M | 1 |
| Koelle, GB; Uchida, E | 1 |
| Ventura, MA | 1 |
| Chadwick, A; Hall, TR; Harvey, S | 1 |
| Flórez, J; Mediavilla, A; Pazos, A | 1 |
| Baquer, NZ; Mayanil, CS | 1 |
| Gillespie, DD; Mishra, R; Sulser, F; Youdim, MB | 1 |
| Radwan, M; Wijsenbeek, H; Zemishlany, Z | 1 |
| Benedetti, MS; Fowler, CJ | 1 |
| Kamijo, K; Kinemuchi, H; Sudo, M; Sunami, Y; Watanabe, K; Yoshino, M | 1 |
| Dallo, J; Knoll, J; Yen, TT | 1 |
| Hertz, L; Yu, PH | 1 |
| Arai, Y; Fowler, CJ; Oreland, L; Stenström, A | 1 |
| Cohen, RM; Garrick, NA; Karoum, F; Linnoila, M; Murphy, DL; Roy, B; Siever, LJ; Wyatt, RJ | 1 |
| Benedetti, MS; Dostert, P; Guffroy, C; Tipton, KF | 1 |
| Fowler, CJ; O'Carroll, AM; Phillips, JP; Tipton, KF; Tobbia, I | 1 |
| Ashkenazi, R; Finberg, JP; Youdim, MB | 1 |
| Glover, V; Pycock, CJ; Sandler, M | 1 |
| Lenzen, S; Nahrstedt, H; Panten, U | 1 |
| Figueroa, HR; Hall, TR; Newton, DK; Yurgens, PB | 1 |
| Banerjee, DK; Pollard, HB; Youdim, MB | 1 |
| Sandler, M | 1 |
| Boden, R; Botting, R; Coulson, P; Spanswick, G | 1 |
| Banchelli, G; Buffoni, F; Fantozzi, R; Ignesti, G; Pirisino, R; Raimondi, L | 1 |
| Inoue, O; Kinemuchi, H; Tominaga, T; Yamasaki, T | 1 |
| Ohishi, N; Sato, M; Yagi, K | 1 |
| Katayama, M; Kobayashi, S; Oguchi, K; Yasuhara, H | 1 |
| Hársing, LG; Vizi, ES | 1 |
| Lewinsohn, R | 1 |
| Linko-Löppönen, S; Männistö, P; Nissinen, E | 1 |
| Lindvall, M; Owman, C | 1 |
| Buckholtz, NS; Sparks, DL | 1 |
| Domino, EF | 1 |
| Katsumata, Y; Matsumoto, T; Oya, M; Stepita-Klauco, M; Suzuki, O | 1 |
| Fowler, CJ; Marcusson, J; Oreland, L; Winblad, B | 1 |
| Guha, SR; Mitra, C | 1 |
| Ancher, JF; Benedetti, MS; Sontag, N | 1 |
| Asano, M; Hattori, H; Katsumata, Y; Oya, M; Suzuki, O | 1 |
| Suzuki, O | 1 |
| Ashford, A; Esmail, A; Glover, V; Sandler, M | 1 |
| Davison, AN; Guest, JF; Lai, JC; Leung, TK; Lim, L | 1 |
| Arai, Y; Kamijo, K; Kinemuchi, H; Wakui, Y | 1 |
| Kamijo, K; Kinemuchi, H; Wakui, Y | 1 |
| Urwyler, S; von Wartburg, JP | 1 |
| Garrick, NA; Murphy, DL | 1 |
| Katsumata, Y; Mizutani, S; Oya, M; Suzuki, O | 1 |
| Deverina, IS | 1 |
| Azzaro, AJ; Schoepp, DD | 3 |
| Lai, JC; Leung, TK; Lim, L | 2 |
| Finberg, JP; Tenne, M; Youdim, MB | 1 |
| Olpe, HR; Schellenberg, A | 1 |
| Demarest, KT; Moore, KE | 1 |
| Klimova, GI; Nersisian, AA; Severina, IS | 1 |
| Egashira, T; Kuroiwa, Y; Yamamoto, T; Yamanaka, Y | 1 |
| Figueroa, HR; Hall, TR; Yurgens, PB | 1 |
| Carr, DO; Kimes, AS | 1 |
| Arai, Y; Kamijo, K; Kawaguchi, T; Kinemuchi, H; Oreland, L; Tajima, H | 1 |
| Fowler, CJ; Mantle, TJ; Tipton, KF | 1 |
| Emerole, GO | 1 |
| Baquer, NZ; Mayanil, K; Shekhar, C | 1 |
| Artigas, F; Celada, P | 2 |
| Holdup, D; Liptrot, J; Phillipson, O | 2 |
| Boulu, RG; Callebert, J; Lancelot, E; Plotkine, M | 1 |
| Bankiewicz, KS; Finberg, JP; Goldstein, DS; Kopin, IJ; Wang, J | 1 |
| Deng, Y; Dostert, P; Maruyama, W; Naoi, M; Takahashi, T; Zhang, JH | 1 |
| Sivam, SP | 1 |
| Czurkó, A; Faludi, B; Karádi, Z; Knoll, J; Lénárd, L; Niedetzky, C; Vida, I | 1 |
| Delanney, LE; Finnegan, KT; Irwin, I; Langston, JW | 1 |
| Hirata, M; Konishi, J; Magata, Y; Murakami, K; Ohmomo, Y; Saji, H; Takagaki, T; Tanaka, C; Yamamura, N; Yokoyama, A | 1 |
| Cabanillas, AM; Coleoni, AH; Costamagna, ME; Masini-Repiso, AM; Pellizas, C | 1 |
| Clarke, C; Whitaker-Azmitia, PM; Zhang, X | 1 |
| Møller, J; Nedergaard, OA | 1 |
| Chia, LG; Kuo, JS; Lee, EH; Yang, YL | 1 |
| Barthalmus, GT; Temple, JG | 1 |
| Benmansour, S; Brunswick, DJ | 1 |
| Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H; Yin, W | 1 |
| Altagracia, M; Bravo-Velazquez, S; Kravzov, J; Ríos, C | 1 |
| Azmitia, EC; Gu, XF | 1 |
| Akiguchi, I; Kimura, J; Nakamura, S | 1 |
| Dixon, CM; Park, GR; Tarbit, MH | 1 |
| Cassels, BK; Dajas, F; Reyes-Parada, M; Scorza, MC; Silveira, R | 1 |
| Abercrombie, ED; Wachtel, SR | 1 |
| Adeyemo, OM; Markey, CJ; Markey, SP; Pollard, HB; Youdim, MB | 1 |
| Anderson, MC; Hasan, F; McCrodden, JM; Tipton, KF | 1 |
| Andrews, AM; Murphy, DL | 1 |
| Blumgart, LH; McCrodden, JM; Shaw, SG; Stuart, ET; Tipton, KF; Wheatley, AM; Zhao, D | 1 |
| Barthalmus, GT; Hardin, LK; Thompson, D | 1 |
| Feuerstein, TJ; Hedler, L; Lücking, CH; Lupp, A | 1 |
| Grimsby, J; Shih, JC; Zentner, M | 1 |
| Griffiths, HR; Lambert, DG; Lunec, J; Willets, JM | 1 |
| Baker, GB; Todd, KG | 1 |
| Hollenberg, PF; Roberts, ES; Sharma, U | 1 |
| Dopico, AM; Guelman, LR; Zieher, LM; Zorrilla Zubilete, MA | 1 |
| Davis, JB; Maher, P | 1 |
| Bernardi, G; Bonci, A; Calabresi, P; Mercuri, NB; Siniscalchi, A; Stefani, A | 1 |
| Finberg, JP; Lamensdorf, I; Youdim, MB | 1 |
| Johnson, MP; Nichols, DE; Schmidt, CJ; Sprague, JE | 1 |
| Chan, P; DeLanney, LE; Di Monte, DA; Irwin, I; Jakowec, MW; Langston, JW; Royland, JE | 1 |
| Cho, S; Duchemin, AM; Hadjiconstantinou, M; Neff, NH | 1 |
| Arai, R; Kimura, H; Maeda, T; Nagatsu, I | 1 |
| Bernardi, G; Bonci, A; Mercuri, NB; Scarponi, M; Siniscalchi, A | 1 |
| Andersen, SL; Baldessarini, RJ; Yeghiayan, SK | 1 |
| Commissiong, JW; Finberg, JP; Johnston, JM; Takeshima, T | 1 |
| Chen, K; Geha, RM; Shih, JC | 2 |
| Cohen, RM; Karoum, F; Lipper, S; Mellow, AM; Murphy, DL; Pickar, D; Sunderland, T; Tariot, PN | 1 |
| Kondakova, LI; Medvedev, AE; Moskvitina, TA; Navasardyantz, DG; Podobed, OV; Tsvetkova, TA; Yakusheva, IV | 1 |
| Croll, RP; Pani, AK | 2 |
| Brannan, T; Martínez-Tica, J; Prikhojan, A; Yahr, MD | 1 |
| Dhingra, NK; Lakshmana, MK; Meti, BL; Raju, TR; Rao, BS; Ravikumar, R; Sudha, S | 1 |
| Caramona, M; Figueiredo, IV; Guimarães, S; Paiva, MQ | 1 |
| Khandwala, H; Loomis, CW | 1 |
| Harris, N; Mazzio, EA; Soliman, KF | 1 |
| Deng, Y; Yu, PH | 1 |
| Chesnut, MD; Jakel, RJ; Maragos, WF; Tillman, PA | 1 |
| Hibell, A; Hudson, AL; Lalies, MD; Nutt, DJ | 1 |
| Ikemoto, K; Jouvet, M; Kitahama, K; Maeda, T; Nagatsu, I | 1 |
| Castagnoli, K; Castagnoli, N; Igarashi, K; Inoue, H; Mabic, S; Van Der Schyf, C | 1 |
| Mukherjee, J; Yang, ZY | 1 |
| Chesnut, MD; Dwoskin, LP; Geddes, JW; Jakel, RJ; Maragos, WF | 1 |
| Ding, YS; Fowler, JS; Franceschi, D; Franceschi, M; Garza, V; Liu, N; Logan, J; MacGregor, R; Shea, C; Volkow, ND; Wang, GJ | 1 |
| Alper, RH; Gilliland, SL; Levant, B | 1 |
| Finberg, JP; Ilani, T; Lamensdorf, I | 1 |
| Armoni, T; Finberg, JP; Lamensdorf, I | 1 |
| Chen, K; Geha, RM; Rebrin, I; Shih, JC | 1 |
| Banchelli, G; Galeotti, N; Ghelardini, C; Pirisino, R; Raimondi, L | 1 |
| Archer, T; Fredriksson, A; Palomo, T | 1 |
| Casas, M; Pérez, V; Prat, G; Rubi, A; Unzeta, M | 1 |
| Bridge, P; Carter, P; Elkashef, A; Fowler, JS; Franceschi, D; Garza, V; Hitzemann, R; Liederman, D; Logan, J; MacGregor, R; Netusil, N; Pappas, N; Rotrosen, J; Shea, C; Volkow, ND; Wang, GJ | 1 |
| Adachi, YU; Higuchi, H; Satoh, T; Vizi, ES; Watanabe, K | 1 |
| Barbelivien, A; Haapalinna, A; Nyman, L; Sirviö, J | 1 |
| Fisher, H; Halladay, AK; Hesse, K; Kirschner, E; Wagner, GC | 1 |
| Gorodetsky, E; Gross, A; Wang, RH; Weinreb, O; Weinstock, M; Youdim, MB | 1 |
| Iida, Y; Ogawa, M; Saji, H; Shimazu, S; Takahata, K; Yoneda, F | 1 |
| Mooney, R; Moriarty, M; Mothersill, C; Seymour, CB; Tipton, KF | 1 |
| Alexoff, D; Ding, YS; Ferrieri, R; Fowler, JS; Garza, V; John Gatley, S; Li, Z; Logan, J; Schlyer, D; Shea, C; Telang, F; Vaska, P; Volkow, ND; Wang, GJ; Xu, Y; Zhu, W | 1 |
| Baker, GB; Holt, A; Todd, KG | 1 |
| Hudson, AL; Nutt, DJ; Paterson, LM; Tyacke, RJ | 1 |
| Carey, GJ; Gold, LH; Nielsen, DM | 1 |
| Nicotra, A; Pierucci, F; Senatori, O; Setini, A | 1 |
| Kitanaka, J; Kitanaka, N; Takemura, M | 1 |
| Fowler, JS; Logan, J | 1 |
| Kitanaka, J; Kitanaka, N; Morita, Y; Takemura, M; Tatsuta, T | 1 |
| Inoue, T; Iwamoto, N; Izumi, T; Kato, A; Kitaichi, Y; Koyama, T | 1 |
| Du, GH; Guang, HM | 1 |
| Cano, E; Fraiz, N; Orallo, F; Yáñez, M | 1 |
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| Han, XH; Hong, SS; Hwang, BY; Hwang, JH; Hwang, JS; Jeong, SH; Lee, D; Lee, MK; Ro, JS | 1 |
| Dell'Antone, P; Drago, D; IbnLkayat, M; Zatta, P | 1 |
| Belluzzi, JD; Franke, RM; Leslie, FM | 1 |
| Burkhardt, JJ; Erickson, DA; Gohdes, M; Hollfelder, S; Krieter, PA; Tenge, J | 1 |
| Blier, P; Chenu, F; El Mansari, M | 1 |
| Miklya, I | 1 |
| Dalal, A; Poddar, MK | 1 |
| Glover, V; Lewinsohn, R; Sandler, M | 1 |
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| Colizza, K; Gunduz, M; Harriman, S; Kamel, A; Obach, RS | 1 |
| Davey, G; Motherway, M; Tipton, KF | 1 |
| Bar-Am, O; Finberg, JP; Friedman, R; Gross, A | 1 |
| Cabreira, TN; Ferreira, J; Oliveira, SM; Silva, CR; Villarinho, JG | 1 |
| Barclay, E; Goyarzu, P; Magallanes, N; Malin, DH; Mathews, H; Mills, WR; Moon, WD; Negrete, AP; Stephens, B; Vela, AJ | 1 |
| Alexoff, DL; Apelskog-Torres, K; Carter, P; Fahn, S; Fowler, JS; Gilmor, M; Hubbard, B; Jayne, M; King, P; Logan, J; McCall-Perez, F; Muench, L; Shea, C; Shumay, E; Telang, F; Volkow, ND; Wang, GJ; Xu, Y | 1 |
| Bhyrapuneni, G; Manoharan, A; Mohammed, AR; Nirogi, R; Palacharla, RC; Ponnamaneni, RK | 1 |
| Ayyannan, SR; Tripathi, RK | 1 |
| Forsblad, A; Hashemian, S; Jacobsson, SO; Popova, D | 1 |
| Binda, C; Corne, R; De Deurwaerdère, P; Fall, Y; Leone, C; Marco-Contelles, J; Ramsay, RR; Valeri, A; Valoti, M | 1 |
| Bhambri, A; Konar, A; Rastogi, M | 1 |
| An, H; Cho, HU; Jang, DP; Kim, S; Lee, CJ; Nam, MH; Sim, J; Yang, S | 1 |
| Bhatia, M; Kapoor, A; Kumar, A; Kumar, P; Kumar, S | 1 |
11 review(s) available for selegiline and clorgyline
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
R-(-)-deprenyl and parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benserazide; Clorgyline; Dopamine; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1987 |
New drug trials in attention deficit disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Clorgyline; Desipramine; Dextroamphetamine; Double-Blind Method; Fenfluramine; Humans; Male; Selegiline; Tranylcypromine | 1985 |
[Interactions between monoaminergic neurons projecting to the cerebral cortex].
Topics: Animals; Cerebral Cortex; Clorgyline; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Receptors, Adrenergic; Receptors, Serotonin; Selegiline | 1985 |
The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications.
Topics: Alkynes; Animals; Binding Sites; Clorgyline; Indans; Indenes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Propylamines; Rats; Selegiline; Substrate Specificity | 1981 |
Monoamine oxidase inhibitors--current status.
Topics: Antidepressive Agents, Tricyclic; Brain Chemistry; Catecholamines; Chemical Phenomena; Chemistry; Clorgyline; Depressive Disorder; Drug Interactions; Humans; Hydrazines; Hypertension; Kinetics; Monoamine Oxidase Inhibitors; Phobic Disorders; Receptors, Adrenergic; Receptors, Serotonin; Selegiline; Tyramine | 1983 |
Monoamine oxidase activity and localisation in the brain and the activity in relation to psychiatric disorders.
Topics: Animals; Brain; Clorgyline; Dopamine; Humans; Mental Disorders; Monoamine Oxidase; Selegiline; Subcellular Fractions | 1983 |
Mammalian monoamine-oxidizing enzymes, with special reference to benzylamine oxidase in human tissues.
Topics: Adult; Animals; Benzylamine Oxidase; Cattle; Cells, Cultured; Child; Clorgyline; Dogs; Female; Fetus; Humans; Infant, Newborn; Kinetics; Monoamine Oxidase; Muscle, Smooth; Pregnancy; Rats; Selegiline; Terminology as Topic; Tissue Distribution; Tissue Extracts; Uterus | 1984 |
[Current status of type A and type B monoamine oxidase (author's transl)].
Topics: Animals; Brain Chemistry; Brain Neoplasms; Cattle; Clorgyline; Glioma; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Substrate Specificity | 1980 |
The advent of selective monoamine oxidase A inhibitor antidepressants devoid of the cheese reaction.
Topics: Benzamides; Cheese; Clorgyline; Depressive Disorder; Humans; Hypertension; Moclobemide; Monoamine Oxidase Inhibitors; Selegiline; Tyramine | 1995 |
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies.
Topics: Aldehydes; Ammonia; Caffeine; Chalcones; Chromones; Clorgyline; Coumarins; Hydrogen Peroxide; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyrazoles; Selegiline; Structure-Activity Relationship; Thiazoles; Thiourea | 2022 |
6 trial(s) available for selegiline and clorgyline
| Article | Year |
|---|---|
Selectivity of clorgyline and pargyline as inhibitors of monoamine oxidases A and B in vivo in man.
Topics: Blood Platelets; Clorgyline; Hemodynamics; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Selegiline | 1979 |
New drug trials in attention deficit disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Clorgyline; Desipramine; Dextroamphetamine; Double-Blind Method; Fenfluramine; Humans; Male; Selegiline; Tranylcypromine | 1985 |
Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline).
Topics: Biogenic Amines; Chromosome Deletion; Clorgyline; Depressive Disorder; Humans; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Reference Values; Retrospective Studies; Selegiline; Tyramine; X Chromosome | 1998 |
Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain.
Topics: Adult; Aged; Brain; Cerebrovascular Circulation; Clorgyline; Female; Ginkgo biloba; Humans; Isoenzymes; Male; Middle Aged; Monoamine Oxidase Inhibitors; Plant Extracts; Plants, Medicinal; Selegiline; Time Factors; Tomography, Emission-Computed | 2000 |
Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans.
Topics: Adult; Brain; Carbon Radioisotopes; Clorgyline; Deuterium; Enzyme Activation; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organ Specificity; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Selegiline; Tissue Distribution | 2004 |
Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Brain; Carbon Radioisotopes; Clorgyline; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Functional Neuroimaging; Humans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Positron-Emission Tomography; Selegiline; Young Adult | 2015 |
404 other study(ies) available for selegiline and clorgyline
| Article | Year |
|---|---|
Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.
Topics: Amines; Animals; Hypothalamus; Indicators and Reagents; Isomerases; Male; Mice; Mice, Inbred Strains; Mitochondria; Monoamine Oxidase Inhibitors; Rats; Structure-Activity Relationship | 1983 |
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.
Topics: Animals; Binding, Competitive; Brain; Kinetics; Male; Mitochondria; Molecular Structure; Monoamine Oxidase Inhibitors; Oxadiazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1993 |
Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.
Topics: Alkynes; Amides; Amines; Animals; Brain; Cattle; Isoenzymes; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrroles; Structure-Activity Relationship | 2003 |
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Topics: Animals; Benzylamines; Binding Sites; Brain; Cattle; In Vitro Techniques; Isoenzymes; Mitochondria; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2007 |
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship | 2008 |
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.
Topics: Chromatography, High Pressure Liquid; Cyclohexanones; Humans; Hydrazones; Inhibitory Concentration 50; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Thermodynamics; Thiazoles; Thiosemicarbazones | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Topics: Binding Sites; Indoles; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Structure-Activity Relationship | 2008 |
Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Topics: Acetamides; Animals; Binding Sites; Catalytic Domain; Drug Design; Humans; Inhibitory Concentration 50; Linezolid; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Pyrazoles; Rats; Siderophores | 2008 |
New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Topics: Binding Sites; Flavin-Adenine Dinucleotide; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrazoles; Quinazolinones | 2009 |
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Topics: Coumarins; Crystallography, X-Ray; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2009 |
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
Topics: Chalcones; Crystallography, X-Ray; Databases, Protein; Drug Design; Humans; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 2009 |
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.
Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrazoles | 2010 |
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.
Topics: Flavanones; Flavones; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Sulfhydryl Compounds | 2010 |
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.
Topics: Binding Sites; Chromones; Computer Simulation; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Isoforms | 2010 |
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrazones; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship; Thiazoles | 2010 |
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.
Topics: Humans; Hydrazines; Hydrogen Peroxide; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2010 |
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.
Topics: Animals; Cell Line; Humans; Insecta; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Structure-Activity Relationship; Thioamides | 2010 |
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.
Topics: Chromatography, High Pressure Liquid; Cyclohexanes; Humans; Hydrazines; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.
Topics: Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Prenylation; Pyrazoles; Structure-Activity Relationship | 2010 |
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.
Topics: Drug Discovery; Flavonoids; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Conformation; Substrate Specificity | 2011 |
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.
Topics: Coumarins; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2011 |
Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B).
Topics: Animals; Autoradiography; Blood Proteins; Blood-Brain Barrier; Brain; Female; Fluorine Radioisotopes; Humans; In Vitro Techniques; Isoenzymes; Male; Mice; Monoamine Oxidase; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Selegiline; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution | 2011 |
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.
Topics: Antiprotozoal Agents; Aporphines; Databases, Factual; Humans; Ligands; Malaria, Falciparum; Markov Chains; Models, Biological; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Plasmodium falciparum; Protozoan Proteins; Quantitative Structure-Activity Relationship; Software; United States | 2011 |
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.
Topics: Binding Sites; Humans; Hydrazones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Conformation; Structure-Activity Relationship; Tandem Mass Spectrometry; Thiazoles | 2012 |
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.
Topics: Alkaloids; Benzodioxoles; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Polyunsaturated Alkamides; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2012 |
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.
Topics: Enzyme Activation; Enzyme Inhibitors; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Structure-Activity Relationship; Tryptophan | 2012 |
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Antioxidants; Benzylidene Compounds; Cations, Divalent; Chelating Agents; Copper; Humans; Indans; Iron; Isoenzymes; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship; Zinc | 2012 |
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B.
Topics: Dose-Response Relationship, Drug; Humans; Molecular Conformation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitriles; Phthalic Acids; Structure-Activity Relationship | 2012 |
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.
Topics: Coumarins; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Spectrophotometry, Infrared | 2012 |
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.
Topics: Dose-Response Relationship, Drug; Humans; Hydrazines; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2012 |
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.
Topics: Cells, Cultured; Curcumin; Enzyme Activation; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase Inhibitors; Quantum Theory; Structure-Activity Relationship | 2013 |
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
Topics: Caffeine; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase Inhibitors; Xanthines | 2013 |
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.
Topics: Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Molecular Structure; Monoamine Oxidase; Pyrazoles; Structure-Activity Relationship | 2013 |
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
Topics: Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Polyamines; Structure-Activity Relationship; Substrate Specificity | 2013 |
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Design; Humans; Isoenzymes; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2014 |
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Hep G2 Cells; Humans; Hydroxyquinolines; Indans; Male; Memory; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Piperidines; Propylamines; Rats | 2014 |
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Membrane Permeability; Cholinesterase Inhibitors; Cholinesterases; Indoles; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Swine | 2014 |
Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors.
Topics: Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrazoles; Structure-Activity Relationship | 2015 |
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Small Molecule Libraries; Thermodynamics | 2015 |
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cations, Divalent; Cell Membrane Permeability; Chelating Agents; Copper; Humans; Iron; Membranes, Artificial; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Reactive Oxygen Species; Selegiline; Solutions; Zinc | 2015 |
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.
Topics: Animals; Carbolines; Cholinesterase Inhibitors; Computational Biology; Excitatory Amino Acid Antagonists; Humans; Indicators and Reagents; Ligands; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2015 |
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.
Topics: Binding Sites; Free Radical Scavengers; Humans; Hydrogen Peroxide; Ketones; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2015 |
Novel 2H-chromen-2-one derivatives of resveratrol: Design, synthesis, modeling and use as human monoamine oxidase inhibitors.
Topics: Chromones; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Resveratrol; Stilbenes; Structure-Activity Relationship | 2015 |
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.
Topics: Acetylcholinesterase; Antioxidants; Chelating Agents; Chemistry Techniques, Synthetic; Donepezil; Drug Design; Humans; Indans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Protein Conformation; Structure-Activity Relationship | 2016 |
Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors.
Topics: Benzoxazines; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrazoles; Structure-Activity Relationship | 2016 |
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.
Topics: Chromans; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Sensitivity and Specificity; Solvents; Structure-Activity Relationship | 2016 |
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship | 2016 |
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzyl Compounds; Binding Sites; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Piperidines; Protein Aggregation, Pathological; Protein Binding; Structure-Activity Relationship | 2017 |
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains.
Topics: Alkynes; Animals; Benzimidazoles; Dose-Response Relationship, Drug; Humans; Hydrazones; Male; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2017 |
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?
Topics: Alanine; Benzylamines; Chromones; Clorgyline; Coumarins; Humans; Indans; Kinetics; Ligands; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Structure-Activity Relationship | 2017 |
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Demethylases; Humans; Methylation; Molecular Docking Simulation; Neoplasms; Tranylcypromine | 2017 |
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.
Topics: Acetylcholinesterase; Animals; Antioxidants; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Horses; Humans; Hydrazones; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship | 2018 |
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzene Derivatives; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Structure-Activity Relationship | 2018 |
Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Dogs; Drug Development; Humans; Madin Darby Canine Kidney Cells; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nervous System Diseases | 2018 |
MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis,
Topics: | 2017 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Targeted Therapy; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 2018 |
Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Demethylases; Humans; Leukemia, Myeloid, Acute; Molecular Docking Simulation; Molecular Structure; Stilbenes; Structure-Activity Relationship; THP-1 Cells | 2018 |
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.
Topics: Cell Line, Tumor; Drug Design; Humans; Monoamine Oxidase; Neuroblastoma; Neuroprotective Agents; Pargyline; Propylamines; Protein Binding; Structure-Activity Relationship | 2019 |
Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Design; Humans; Isatin; Molecular Dynamics Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Isoforms; Structure-Activity Relationship | 2019 |
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.
Topics: Antiparkinson Agents; Clorgyline; Drug Design; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Conformation; Selegiline; Structure-Activity Relationship | 2019 |
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
Topics: Alkaloids; Benzodioxoles; Caco-2 Cells; Cell Differentiation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alanine; Amides; Animals; Benzylamines; Binding Sites; Dopaminergic Neurons; Drug Design; Humans; Male; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease, Secondary; Protein Binding; Structure-Activity Relationship | 2020 |
Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors - design, synthesis, biological evaluation and molecular modelling.
Topics: | 2020 |
Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Histone Demethylases; Humans; Molecular Structure; Structure-Activity Relationship; Tranylcypromine | 2021 |
Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinoxalines; Structure-Activity Relationship | 2021 |
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase.
Topics: Humans; Indans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Propylamines; Selegiline; Tetrahydronaphthalenes; Tyramine | 2022 |
Effect of beta-fluorophenethylamine analogs on monoamine oxidase substrate preference.
Topics: Animals; Brain; Clorgyline; Hydrogen-Ion Concentration; In Vitro Techniques; Mitochondria; Monoamine Oxidase; Phenethylamines; Rats; Selegiline; Substrate Specificity | 1978 |
The metabolism of 5-hydroxytryptamine and beta-phenylethylamine in perfused rat lung and in vitro.
Topics: Animals; Clorgyline; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lung; Male; Mitochondria; Monoamine Oxidase; Phenethylamines; Rats; Selegiline; Serotonin; Substrate Specificity | 1979 |
Selective influences of age and thyroid hormones on type A monoamine oxidase of the rat heart.
Topics: Aging; Animals; Clorgyline; Heart; In Vitro Techniques; Monoamine Oxidase; Myocardium; Organ Size; Rats; Selegiline; Substrate Specificity; Thyroid Hormones | 1979 |
Oxidation of beta-phenylethylamine by both types of monoamine oxidase: effects of substrate concentration and pH.
Topics: Animals; Brain; Clorgyline; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Phenethylamines; Rats; Selegiline; Substrate Specificity | 1979 |
MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats.
Topics: 5-Methoxytryptamine; Animals; Avoidance Learning; Brain Chemistry; Clorgyline; Injections, Intraventricular; Iproniazid; Lysergic Acid Diethylamide; Male; Monoamine Oxidase Inhibitors; Rats; Selegiline; Serotonin; Tryptamines | 1979 |
Brain region differences and some characteristics of monoamine oxidase type A and B activities in the vervet monkey.
Topics: Animals; Brain; Chlorocebus aethiops; Clorgyline; Haplorhini; Isoenzymes; Kinetics; Monoamine Oxidase; Selegiline; Tissue Distribution | 1979 |
Synthetic rates of monoamine oxidase in rat liver after clorglyine or deprenyl administration.
Topics: Animals; Clorgyline; Male; Microsomes, Liver; Mitochondria, Liver; Monoamine Oxidase; Phenethylamines; Propylamines; Rats; Selegiline; Time Factors | 1979 |
Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas.
Topics: Adenoma, Islet Cell; Animals; Catechol O-Methyltransferase; Clorgyline; Cricetinae; Dopamine; Kinetics; Monoamine Oxidase; Neoplasms, Experimental; Norepinephrine; Rats; Selegiline; Serotonin; Species Specificity; Tissue Distribution | 1979 |
The effect of selective monoamine oxidase inhibitors, clorgyline and deprenyl, upon tissue glycogen stores and blood glucose levels.
Topics: Animals; Blood Glucose; Brain; Clorgyline; Dose-Response Relationship, Drug; Glycogen; Liver; Myocardium; Phenethylamines; Propylamines; Rats; Selegiline | 1978 |
Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on 3H-serotonin receptor binding in rat brain.
Topics: Animals; Brain; Clomipramine; Clorgyline; Fluoxetine; Male; Monoamine Oxidase Inhibitors; Rats; Receptors, Serotonin; Selegiline; Serotonin Antagonists | 1979 |
Oxidation of phenylethanolamine and octopamine by type A and type B monoamine oxidase. Effect of substrate concentration.
Topics: 2-Hydroxyphenethylamine; Animals; Brain; Clorgyline; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Octopamine; Oxidation-Reduction; Phenethylamines; Proteins; Rats; Selegiline | 1979 |
m-Octopamine as a substrate for monoamine oxidase.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Octopamine; Rats; Selegiline | 1979 |
Distinct forms of monoamine oxidase expressed in hepatoma and HeLa cells in culture.
Topics: Animals; Cells, Cultured; Clorgyline; HeLa Cells; Humans; Kinetics; Liver Neoplasms, Experimental; Monoamine Oxidase; Phenethylamines; Proteins; Rats; Selegiline; Serotonin; Substrate Specificity; Tryptamines | 1979 |
Tele-methylhistamine oxidation by type B monoamine oxidase.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Methylhistamines; Monoamine Oxidase; Rats; Selegiline | 1979 |
Characterization of rat pulmonary monoamine oxidase.
Topics: Animals; Clorgyline; Kinetics; Lung; Male; Monoamine Oxidase; Oxidation-Reduction; Phenethylamines; Rats; Selegiline; Serotonin; Substrate Specificity; Tyramine | 1979 |
[Possible mechanism of selective inhibition of rat liver mitochondrial monoamine oxidase by chlorgiline and deprenyl].
Topics: Animals; Binding, Competitive; Clorgyline; Kinetics; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Rats; Selegiline | 1979 |
On the characteristics of mitochondrial monoamine oxidase in pancreas and adipose tissues from genetically obese mice.
Topics: Adipose Tissue; Animals; Clorgyline; Male; Mice; Mice, Obese; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pancreas; Selegiline; Substrate Specificity | 1979 |
Liver monoamine oxidase in the obese-hyperglycaemic (ob/ob) mouse.
Topics: Animals; Clorgyline; Female; In Vitro Techniques; Kinetics; Lipid Metabolism; Male; Mice; Mice, Obese; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Selegiline; Substrate Specificity | 1979 |
Distribution and inhibition characteristics of human brain monoamine oxidase.
Topics: Aged; Benzylamines; Brain; Clorgyline; Dopamine; Female; Humans; In Vitro Techniques; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Serotonin; Substrate Specificity; Tyramine | 1979 |
Substrate specificity and inhibitor sensitivity of monoamine oxidase in rat kidney mitochondria.
Topics: Animals; Clorgyline; Guanidines; Histamine; In Vitro Techniques; Isoniazid; Kidney; Kinetics; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Selegiline; Semicarbazides; Substrate Specificity | 1979 |
Studies of monoamine oxidases. Inhibition of bovine brain MAO in intact mitochondria by tricyclic antidepressant drugs.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cattle; Clorgyline; Drug Interactions; In Vitro Techniques; Kinetics; Mitochondria; Monoamine Oxidase Inhibitors; Phenethylamines; Selegiline; Serotonin; Substrate Specificity; Tranylcypromine | 1979 |
Cumulative effects of irreversible MAO inhibitors in vivo.
Topics: Animals; Brain; Clorgyline; Female; Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Selegiline; Serotonin; Time Factors; Tranylcypromine | 1979 |
Effect of beta-phenylethylamine concentration on its substrate specificity for type A and type B monoamine oxidase.
Topics: Animals; Benzylamines; Brain; Clorgyline; In Vitro Techniques; Male; Mitochondria; Monoamine Oxidase; Osmolar Concentration; Phenethylamines; Rats; Selegiline; Substrate Specificity | 1979 |
Association of monoamine oxidase with lipid--a comparative study mitochondria from Novikoff hepatoma and rat liver.
Topics: Animals; Clorgyline; Enzyme Activation; Freezing; Ketones; Lipid Metabolism; Liver Neoplasms, Experimental; Mitochondria, Liver; Monoamine Oxidase; Phospholipids; Rats; Selegiline; Temperature | 1979 |
The reaction of bovine and rat liver monoamine oxidase with [14C]-clorgyline and [14C]-deprenyl.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Clorgyline; In Vitro Techniques; Liver; Mitochondria, Liver; Monoamine Oxidase; Phenethylamines; Propylamines; Protein Binding; Rats; Selegiline | 1979 |
Oxidation of synephrine by type A and type B monoamine oxidase.
Topics: Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; Kinetics; Male; Mitochondria; Monoamine Oxidase; Rats; Selegiline; Synephrine | 1979 |
1,4-Methylhistamine is a specific substrate for type B monoamine oxidase.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Methylhistamines; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Rats; Selegiline | 1979 |
Substrate specificity of monoamine oxidase in pig liver mitochondria.
Topics: Animals; Clorgyline; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Selegiline; Serotonin; Substrate Specificity; Swine | 1979 |
Monoamine oxidase activity of macrophages at rest and during phagocytosis.
Topics: Animals; Clorgyline; Deamination; Isoenzymes; Latex; Macrophages; Mice; Microspheres; Monoamine Oxidase; Phagocytosis; Selegiline | 1978 |
The effect of monoamine oxidase inhibitors on some arylalkylamines in rate striatum.
Topics: Amines; Animals; Clorgyline; Corpus Striatum; Iproniazid; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Selegiline; Tranylcypromine; Tryptamines; Tyramine | 1979 |
Phenylethanolamine is a specific substrate for type B monoamine oxidase.
Topics: 2-Hydroxyphenethylamine; Animals; Brain; Chromatography, Thin Layer; Clorgyline; In Vitro Techniques; Kinetics; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Rats; Selegiline; Serotonin | 1978 |
Phenylethylamine--deamination by multiple types of monoamine oxidase.
Topics: Animals; Clorgyline; Deamination; In Vitro Techniques; Isoenzymes; Kinetics; Liver; Male; Monoamine Oxidase; Myocardium; Phenethylamines; Rats; Selegiline; Vas Deferens | 1978 |
Multiple catalytic sites of rat brain mitochondrial monoamine oxidase.
Topics: Animals; Binding Sites; Brain; Clorgyline; Kinetics; Male; Mathematics; Mitochondria; Monoamine Oxidase; Rats; Selegiline; Substrate Specificity | 1978 |
The active centers of monoamine oxidase types "A" and "B": binding with (14C)-clorgyline and (14C)-deprenyl.
Topics: Animals; Binding Sites; Brain; Cattle; Clorgyline; Flavoproteins; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenylhydrazines; Selegiline; Spectrum Analysis; Substrate Specificity | 1978 |
Multiple forms of monoamine oxidase in developing chick brain.
Topics: Animals; Brain; Catalysis; Clorgyline; Guanidines; Isoenzymes; Kynuramine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Selegiline; Semicarbazides | 1978 |
Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Dialysis; Free Radicals; Hydroxides; Hydroxyl Radical; Rats; Selegiline | 1992 |
Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Catechols; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Nitriles; Nitrophenols; Nomifensine; Rats; Rats, Inbred Strains; Selegiline; Tolcapone | 1992 |
Deprenyl alters behavior and caudate dopamine through an amphetamine-like action.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Behavior, Animal; Caudate Nucleus; Clorgyline; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Selegiline | 1992 |
Antidepressants and brain respiration.
Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Chlorides; Chlorpromazine; Clorgyline; Glucose; Imipramine; Lithium; Lithium Chloride; Male; Oxygen Consumption; Rats; Selegiline; Tranylcypromine | 1991 |
Acute toxicity of three new selective COMT inhibitors in mice with special emphasis on interactions with drugs increasing catecholaminergic neurotransmission.
Topics: Amphetamine; Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catecholamines; Catechols; Clorgyline; Convulsants; Desipramine; Drug Interactions; Lethal Dose 50; Levodopa; Male; Mice; Motor Activity; Nitriles; Nomifensine; Pentanones; Selegiline; Synaptic Transmission; Yohimbine | 1991 |
Rat thyroid monoamine oxidase (MAO) is regulated by thyrotrophin: evidence that the main form of the enzyme (MAO-A) is not directly involved in iodide organification.
Topics: Animals; Bucladesine; Clorgyline; Depression, Chemical; Iodides; Isoenzymes; Male; Methimazole; Monoamine Oxidase; Rats; Rats, Inbred Strains; Selegiline; Theophylline; Thyroid Gland; Thyrotropin; Thyroxine | 1991 |
Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Survival; Clone Cells; Clorgyline; Isoenzymes; Kinetics; Monoamine Oxidase; Neuroblastoma; Neurons; Selegiline | 1991 |
Characterization of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) binding sites in C57BL/6 mouse brain: mutual effects of monoamine oxidase inhibitors and sigma ligands on MPTP and sigma binding sites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Membrane; Clorgyline; Kinetics; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Receptors, Opioid; Receptors, sigma; Selegiline | 1991 |
Differential effects of angiotensin II and eledoisin on monoamine oxidase A and B activities in rat brain.
Topics: Angiotensin II; Animals; Benzylamines; Brain; Clorgyline; Eledoisin; Injections, Intraventricular; Isotonic Solutions; Male; Monoamine Oxidase; Octopamine; Rats; Rats, Inbred Strains; Selegiline; Tissue Distribution | 1991 |
Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase.
Topics: Animals; Benzylamines; Clorgyline; Glutathione; Hydrogen Peroxide; Male; Mice; Mitochondria, Liver; Monoamine Oxidase; Selegiline; Substrate Specificity | 1991 |
Modulation of vocal and nonvocal behavior in adult squirrel monkeys by selective MAO-A and MAO-B inhibition.
Topics: Acetamides; Animals; Clorgyline; Dose-Response Relationship, Drug; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Reference Values; Saimiri; Selegiline; Social Behavior; Social Isolation; Vocalization, Animal | 1991 |
Deamination of norepinephrine, dopamine, and serotonin by type A monoamine oxidase in discrete regions of the rat brain and inhibition by RS-8359.
Topics: Animals; Benzamides; Biogenic Monoamines; Brain; Cerebral Cortex; Clorgyline; Corpus Striatum; Deamination; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Male; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitriles; Norepinephrine; Pyrimidines; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1991 |
Evaluation of the effects of inhibition of monoamine oxidase and senescence on methamphetamine-induced neuronal damage.
Topics: Aging; Animals; Clorgyline; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nervous System Diseases; Neurons; Selegiline | 1991 |
Monoamine oxidase activity in rat and human odontoblasts: a microgasometric study.
Topics: Adult; Animals; Clorgyline; Histocytochemistry; Humans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Odontoblasts; Rats; Selegiline; Tooth | 1991 |
Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Biotransformation; Cells, Cultured; Clorgyline; Cytochrome P-450 Enzyme System; Mice; Monoamine Oxidase; Oxygenases; Selegiline | 1991 |
Monoamine oxidase inhibitors prevent striatal neuronal necrosis induced by transient forebrain ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Ischemic Attack, Transient; Isoenzymes; Male; Monoamine Oxidase Inhibitors; Necrosis; Neurons; Nitriles; Pyrimidines; Rats; Rats, Inbred Strains; Reperfusion; Selegiline | 1991 |
Monoamine oxidase activity in embryos of pike (Esox lucius).
Topics: Animals; Blastocyst; Cleavage Stage, Ovum; Clorgyline; Gastrula; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Ovum; Phenethylamines; Salmonidae; Selegiline; Serotonin; Tryptamines | 1990 |
Isoelectric analysis of 3H-pargyline-labelled monoamine oxidase in rat and carp.
Topics: Animals; Brain; Carps; Clorgyline; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Isoelectric Point; Male; Mitochondria; Mitochondria, Liver; Molecular Weight; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum.
Topics: Amphetamine; Animals; Catecholamines; Clorgyline; Corpus Striatum; Dopamine; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Potassium; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Veratrine | 1990 |
Enhancement of rat brain cytosolic monoamine oxidase activity by clorgyline. Comparison with (-)-deprenyl and MDL 72145.
Topics: Allylamine; Brain Chemistry; Clorgyline; Cytosol; Dose-Response Relationship, Drug; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Polyethylene Glycols; Receptors, Drug; Selegiline | 1990 |
Effect of selective monoamine oxidase A and B inhibitors on footshock induced aggression in paired rats.
Topics: Aggression; Animals; Apomorphine; Clorgyline; Female; Male; Monoamine Oxidase; Nialamide; Pain; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Role of type A and B monoamine oxidase on the formation of 3,4-dihydroxyphenylacetic acid (DOPAC) in tissues from the brain of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cerebral Cortex; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Isoenzymes; Male; Monoamine Oxidase; Nucleus Accumbens; Pargyline; Rats; Rats, Inbred Strains; Reference Values; Selegiline | 1990 |
Type-specific localization of monoamine oxidase in the enteric nervous system: relationship to 5-hydroxytryptamine, neuropeptides, and sympathetic nerves.
Topics: Animals; Calcitonin Gene-Related Peptide; Clorgyline; Duodenum; Guinea Pigs; Isoenzymes; Jejunum; Kinetics; Male; Mice; Monoamine Oxidase; Muscle, Smooth; Myenteric Plexus; Neuropeptide Y; Neuropeptides; Selegiline; Serotonin; Sympathetic Nervous System; Vasoactive Intestinal Peptide | 1990 |
Catalytically active monoamine oxidase type A from human liver expressed in Saccharomyces cerevisiae contains covalent FAD.
Topics: Base Sequence; Cloning, Molecular; Clorgyline; DNA; DNA, Recombinant; Flavin-Adenine Dinucleotide; Fluorescence; Humans; Kinetics; Liver; Molecular Sequence Data; Monoamine Oxidase; Placenta; Restriction Mapping; Saccharomyces cerevisiae; Selegiline | 1990 |
Comparative studies on semicarbazide-sensitive amine oxidase in heart and plasma of rats treated with hepatotoxin allyl formate.
Topics: Animals; Clorgyline; Formic Acid Esters; Isoelectric Focusing; Isoelectric Point; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Rats; Rats, Inbred Strains; Selegiline; Semicarbazides | 1990 |
Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat.
Topics: Administration, Oral; Amphetamines; Animals; Clorgyline; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Monoamine Oxidase; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1990 |
Monoamine oxidase and oxidative stress at dopaminergic synapses.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Glutathione; Glutathione Reductase; Haloperidol; In Vitro Techniques; Levodopa; Male; Mice; Monoamine Oxidase; Oxidation-Reduction; Rats; Rats, Inbred Strains; Reserpine; Selegiline; Stress, Physiological; Substantia Nigra; Synapses; Synaptosomes | 1990 |
Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye.
Topics: Amine Oxidase (Copper-Containing); Animals; Cattle; Clorgyline; Epithelium; Eye; Iris; Lens, Crystalline; Monoamine Oxidase; Optic Nerve; Retina; Selegiline | 1990 |
In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism in rat brain areas.
Topics: Animals; Brain; Clorgyline; Corpus Striatum; Dopamine; Electrodes, Implanted; Locus Coeruleus; Monoamine Oxidase Inhibitors; Pargyline; Raphe Nuclei; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Stereotaxic Techniques | 1990 |
The effects of monoamine oxidase inhibition and dopamine uptake blockade on MPTP-induced increase of 2-[3H]deoxyglucose uptake in specific mesencephalic catecholaminergic nuclei.
Topics: Animals; Clorgyline; Deoxy Sugars; Deoxyglucose; Dopamine; Indoles; Mazindol; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Selegiline; Substantia Nigra; Tegmentum Mesencephali | 1990 |
In vivo labelling and axonal transport of monoamine oxidase in the rat basal ganglia using radioactive pargyline.
Topics: Animals; Axonal Transport; Basal Ganglia; Clorgyline; Corpus Striatum; Female; Hydroxydopamines; Kainic Acid; Male; Monoamine Oxidase; Oxidopamine; Pargyline; Premedication; Rats; Rats, Inbred Strains; Selegiline; Substantia Nigra | 1986 |
Relationship between extracellular 5-hydroxytryptamine and behaviour following monoamine oxidase inhibition and L-tryptophan.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Clorgyline; Hydroxyindoleacetic Acid; Indoles; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Time Factors; Tranylcypromine; Tryptophan; Tyrosine | 1988 |
Effect of selective monoamine oxidase inhibitors on rat pineal melatonin synthesis in vitro.
Topics: Animals; Arylamine N-Acetyltransferase; Clorgyline; Hydroxyindoleacetic Acid; Hydroxytryptophol; Melatonin; Monoamine Oxidase; Norepinephrine; Organ Culture Techniques; Phenethylamines; Pineal Gland; Propranolol; Propylamines; Rats; Rats, Inbred F344; Rats, Inbred Strains; Selegiline; Serotonin; Tryptophan | 1988 |
The effect of selective type A or type B monoamine oxidase inhibition on the intrasynaptosomal deamination of (3H)serotonin in rat spinal cord tissue.
Topics: Animals; Clorgyline; Cytoplasm; Deamination; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Spinal Cord; Synaptosomes | 1988 |
Determination of the absolute concentrations of monoamine oxidase A and B in human tissues.
Topics: Autopsy; Binding Sites; Blood Platelets; Brain; Clorgyline; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Placenta; Selegiline | 1989 |
Steroid regulation of monoamine oxidase activity in the adrenal medulla.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin System; Clorgyline; Dexamethasone; DNA; Endothelium; Estradiol; Hydrocortisone; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Progesterone; Protein Biosynthesis; Selegiline; Steroids; Testosterone | 1989 |
Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells.
Topics: Cell Line; Clorgyline; DNA; Humans; Isoenzymes; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Selegiline; Serotonin; Substrate Specificity; Transfection | 1989 |
Potentiation of para-hydroxyamphetamine-induced head-twitch response by inhibition of monoamine oxidase type A in the brain.
Topics: Amphetamines; Animals; Brain; Cerebral Ventricles; Clorgyline; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Monoamine Oxidase Inhibitors; p-Hydroxyamphetamine; Pargyline; Selegiline; Stereotyped Behavior | 1989 |
Characterization of monoamine oxidase activity present in human granulocytes and lymphocytes.
Topics: Adult; Binding Sites; Clorgyline; Granulocytes; Humans; Kinetics; Lymphocytes; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Semicarbazides; Substrate Specificity | 1989 |
Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechols; Clorgyline; Corpus Striatum; Debrisoquin; Homovanillic Acid; Male; Methoxyhydroxyphenylglycol; Monoamine Oxidase Inhibitors; Nialamide; Norepinephrine; Rats; Rats, Inbred Strains; Selegiline | 1989 |
Monoamine oxidase-containing nerve fibers in the major cerebral arteries of rats.
Topics: Adrenergic Fibers; Animals; Cerebral Arteries; Clorgyline; Enzyme Inhibitors; Histocytochemistry; Male; Microscopy, Electron; Monoamine Oxidase; Rats; Rats, Inbred Strains; Schwann Cells; Selegiline | 1989 |
Modification of substrate-inhibitor affinities of human platelet monoamine oxidase B in vitro.
Topics: Antibodies; Antigen-Antibody Complex; Benzylamines; Blood Platelets; Clorgyline; Female; Humans; Intracellular Membranes; Isoenzymes; Kinetics; Mitochondria; Monoamine Oxidase; Octopamine; Phenethylamines; Placenta; Pregnancy; Propylamines; Selegiline; Substrate Specificity; Thermodynamics | 1989 |
Selective pressor enhancement by monoamine oxidase inhibitors in conscious rats.
Topics: Animals; Blood Pressure; Clorgyline; Heart Rate; Male; Monoamine Oxidase Inhibitors; Phenylephrine; Rats; Rats, Inbred Strains; Selegiline; Tyramine | 1989 |
In vivo degradation of noradrenaline by MAO A in locus coeruleus of the rat.
Topics: Animals; Clorgyline; Female; Histocytochemistry; Locus Coeruleus; Microscopy, Fluorescence; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Reserpine; Selegiline | 1989 |
Monoamine oxidase (MAO) activity and its forms in normal and pathological human thyroid tissues.
Topics: Adenoma; Carcinoma; Clorgyline; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neoplasms, Germ Cell and Embryonal; Reference Values; Selegiline; Thyroid Diseases; Thyroid Gland; Thyroid Neoplasms | 1989 |
Deamination of aliphatic amines of different chain lengths by rat liver monoamine oxidase A and B.
Topics: Amines; Animals; Clorgyline; Deamination; In Vitro Techniques; Liver; Monoamine Oxidase; Rats; Selegiline; Structure-Activity Relationship | 1989 |
Comparative sensitivities of purified preparations of lysyl oxidase and other amine oxidases to active site-directed enzyme inhibitors.
Topics: Amine Oxidase (Copper-Containing); Amino Acid Oxidoreductases; Aminopropionitrile; Animals; Binding Sites; Cattle; Clorgyline; Enzyme Inhibitors; Fibrosis; Guanidines; Humans; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein-Lysine 6-Oxidase; Selegiline | 1989 |
Selective inhibition of MAO-A but not MAO-B activity increases rat pineal melatonin.
Topics: Animals; Clorgyline; Hydroxyindoleacetic Acid; Isoenzymes; Male; Melatonin; Phenethylamines; Pineal Gland; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1985 |
Mitochondrial monoamine oxidase activity during preneural developmental stages of Bufo bufo.
Topics: Animals; Bufo bufo; Clorgyline; Embryo, Nonmammalian; Female; Kinetics; Male; Mitochondria; Monoamine Oxidase; Nervous System; Selegiline; Urea | 1985 |
Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors.
Topics: Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; Hydrazines; Hypothalamus; Iproniazid; Male; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Reserpine; Selegiline; Tranylcypromine | 1986 |
Suppression of the hypo- and hyperthermic responses to 5-HT agonists following the repeated administration of monoamine oxidase inhibitors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Brain; Clorgyline; Male; Monoamine Oxidase Inhibitors; Nialamide; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Tetrahydronaphthalenes | 1986 |
Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat.
Topics: Animals; Cerebral Cortex; Citalopram; Clomipramine; Clorgyline; Kinetics; Male; Membranes; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1987 |
Reduced peripheral presynaptic adrenoceptor sensitivity following chronic antidepressant treatment in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clorgyline; Cocaine; Desipramine; Electric Stimulation; In Vitro Techniques; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Neurotransmitter; Selegiline; Tranylcypromine; Vas Deferens | 1985 |
Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors.
Topics: Animals; Clonidine; Clorgyline; Locus Coeruleus; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Phenelzine; Raphe Nuclei; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Synaptic Transmission | 1985 |
Human plasma melatonin is elevated during treatment with the monoamine oxidase inhibitors clorgyline and tranylcypromine but not deprenyl.
Topics: Blood Platelets; Clorgyline; Depressive Disorder; Female; Humans; Male; Melatonin; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Receptors, Adrenergic, beta; Selegiline; Tranylcypromine | 1986 |
Histochemical studies on human placental and chorionic monoamine oxidase.
Topics: Chorion; Chorionic Villi; Clorgyline; Female; Gestational Age; Histocytochemistry; Humans; Monoamine Oxidase; Placenta; Pregnancy; Selegiline | 1986 |
Monoamine oxidase: an important intracellular regulator of gastrin release in the rat.
Topics: Animals; Clorgyline; Food Additives; Gastrins; Male; Monoamine Oxidase Inhibitors; Nialamide; Organic Chemicals; Pyloric Antrum; Rats; Rats, Inbred Strains; Selegiline | 1986 |
Assignment of A and B types of monoamine oxidase in NCB20 hybrid cells to those of the parental cells by peptide mapping.
Topics: Animals; Brain; Cell Line; Chymotrypsin; Clorgyline; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Flavin-Adenine Dinucleotide; Hybrid Cells; Mice; Mice, Inbred A; Mitochondria; Molecular Weight; Monoamine Oxidase; Pargyline; Peptide Fragments; Selegiline | 1986 |
The effect of repeated administration of (-) deprenyl on the phenylethylamine-induced stereotypy in rats.
Topics: Alkynes; Animals; Clorgyline; Female; Indans; Male; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Stereotyped Behavior | 1986 |
Prevention of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic toxicity in mice by MDL 72145, a selective inhibitor of MAO-B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Allylamine; Amines; Animals; Brain; Clorgyline; Dopamine; Male; Mice; Mitochondria; Monoamine Oxidase Inhibitors; Pyridines; Selegiline | 1986 |
The rational design of suicide substrates of amine oxidases.
Topics: Amine Oxidase (Copper-Containing); Animals; Binding Sites; Clorgyline; Copper; Isoenzymes; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Selegiline | 1986 |
Decreased monoamine oxidase activity in stroke-prone spontaneously hypertensive rat kidneys.
Topics: Animals; Cerebrovascular Disorders; Clorgyline; Hypertension; In Vitro Techniques; Kidney; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Selegiline | 1986 |
Inhibition of monoamine oxidase by 3,4-dihydroxyphenylserine.
Topics: Clorgyline; Droxidopa; Female; Humans; Kinetics; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Placenta; Pregnancy; Selegiline; Serine; Stereoisomerism | 1986 |
The effects of monoamine oxidase inhibitors on the ejaculatory response induced by 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Benzamides; Clorgyline; Dose-Response Relationship, Drug; Ejaculation; Male; Methoxydimethyltryptamines; Moclobemide; Monoamine Oxidase Inhibitors; Nialamide; p-Chloroamphetamine; Pargyline; Rats; Receptors, Serotonin; Selegiline; Serotonin; Time Factors | 1986 |
Monoamine oxidase in rat ovary during the estrous cycle. A histochemical study by a new coupled peroxidatic oxidation method.
Topics: Animals; Blood Vessels; Clorgyline; Corpus Luteum; Estrus; Female; Histocytochemistry; Horseradish Peroxidase; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Ovary; Oxidation-Reduction; Rats; Rats, Inbred Strains; Selegiline | 1986 |
The oxidation of tryptamine by the two forms of monoamine oxidase in human tissues.
Topics: Brain; Clorgyline; Humans; Kidney; Kinetics; Liver; Monoamine Oxidase; Oxidation-Reduction; Selegiline; Tryptamines | 1986 |
Modulation by phospholipids of the activity of monoamine oxidase purified from pig liver.
Topics: Animals; Benzylamines; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clorgyline; Kinetics; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Selegiline; Serotonin; Spleen; Substrate Specificity; Swine | 1986 |
Possible melatonin involvement in the hypotensive effect of MAO inhibitors.
Topics: Animals; Blood Pressure; Clorgyline; Isoenzymes; Male; Melatonin; Monoamine Oxidase Inhibitors; Pargyline; Pineal Gland; Rats; Rats, Inbred Strains; Selegiline | 1986 |
Primate-rodent 3H-MPTP binding differences, and biotransformation of MPTP to a reactive intermediate in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Biotransformation; Brain; Clorgyline; In Vitro Techniques; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains; Saimiri; Selegiline | 1986 |
Demonstration of monoamine oxidase type B in serotonergic and type A in noradrenergic neurons in the cat dorsal pontine tegmentum by an improved histochemical technique.
Topics: Animals; Axons; Cats; Clorgyline; Dendrites; Histocytochemistry; Horseradish Peroxidase; Monoamine Oxidase; Norepinephrine; p-Dimethylaminoazobenzene; Phenethylamines; Pons; Propylamines; Selegiline; Serotonin | 1986 |
Monoamine oxidase in bovine thyroid tissue.
Topics: Animals; Biogenic Amines; Cattle; Clorgyline; Monoamine Oxidase; Phenethylamines; Selegiline; Serotonin; Subcellular Fractions; Substrate Specificity; Thyroid Gland; Tyramine | 1986 |
Distribution of the two forms of monoamine oxidase within monoaminergic neurons of the guinea pig brain.
Topics: Animals; Brain; Clorgyline; Dopamine; Guinea Pigs; Isoenzymes; Male; Monoamine Oxidase; Neurons; Norepinephrine; Selegiline; Tissue Distribution | 1987 |
Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET.
Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Stem; Cerebral Cortex; Clorgyline; Corpus Striatum; Humans; Monoamine Oxidase; Selegiline; Thalamus; Tomography, Emission-Computed | 1987 |
SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. I. Psychopharmacological profile in rodents.
Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Body Temperature; Catalepsy; Clorgyline; Drug Interactions; Female; Haloperidol; Imipramine; Levodopa; Male; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Nomifensine; Oxotremorine; Pargyline; Piperidines; Pyridazines; Rats; Rats, Inbred Strains; Reserpine; Selegiline; Stereotyped Behavior | 1987 |
SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. II. Biochemical characterization of monoamine oxidase inhibition.
Topics: Animals; Benzamides; Biogenic Amines; Brain; Clorgyline; Dopamine; Duodenum; Harmaline; Isoenzymes; Liver; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Pyridazines; Rats; Selegiline; Synaptosomes | 1987 |
Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Female; Half-Life; Isoenzymes; Kinetics; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Phenethylamines; Placenta; Pregnancy; Pyridines; Rats; Selegiline; Serotonin | 1986 |
Long-term administration of (-)deprenyl (selegiline), a compound which facilitates dopaminergic tone in the brain, leaves the sensitivity of dopamine receptors to apomorphine unchanged.
Topics: Animals; Apomorphine; Clorgyline; Dextroamphetamine; Drug Interactions; Female; Haloperidol; Imipramine; Male; Phenethylamines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Selegiline; Stereotyped Behavior | 1986 |
Effect of selective monoamine oxidase inhibitors on the morphine-induced hypothermia in restrained rats.
Topics: Animals; Body Temperature; Clorgyline; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Monoamine Oxidase Inhibitors; Morphine; Naloxone; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline | 1987 |
Conditioned taste aversion induced in rats by intracerebral or systemic administration of monoamine oxidase inhibitors.
Topics: Animals; Avoidance Learning; Brain; Clorgyline; Injections; Injections, Intraperitoneal; Male; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline; Taste | 1987 |
Effects of different monoamine oxidase inhibitors on the metabolism of L-dopa in the rat brain.
Topics: Animals; Brain; Catecholamines; Clorgyline; Corpus Striatum; Dopamine; Hypothalamus; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1987 |
Enzyme histochemistry of monoamine oxidase in the heart of aged rats.
Topics: Aging; Animals; Clorgyline; Heart; Histocytochemistry; Male; Monoamine Oxidase; Myocardium; Rats; Rats, Inbred Strains; Selegiline | 1987 |
Chronic inhibition of monoamine oxidase reduces noradrenaline release in rat vas deferens and anococcygeus muscle.
Topics: Animals; Clorgyline; Electric Stimulation; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Muscle, Smooth, Vascular; Muscles; Nialamide; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Selegiline; Time Factors; Vas Deferens; Veratrine | 1987 |
Marked enhancement by clorgyline of nocturnal and daytime melatonin release in rhesus monkeys.
Topics: Animals; Circadian Rhythm; Clorgyline; Macaca mulatta; Male; Melatonin; Pineal Gland; Propylamines; Selegiline | 1987 |
Evidence for existence of A and B form monoamine oxidase in mitochondria from dog platelets.
Topics: Animals; Blood Platelets; Brain; Clorgyline; Dogs; Hot Temperature; Kinetics; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Selegiline; Substrate Specificity; Trypsin | 1987 |
[3H]tryptamine binding sites of rat cerebral cortex: pharmacological profile and plasticity.
Topics: Animals; Binding Sites; Carbolines; Cerebral Cortex; Clorgyline; Kinetics; Male; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Structure-Activity Relationship; Tryptamines | 1987 |
Differential postnatal development of monoamine oxidases A and B in the blood-brain barrier of the rat.
Topics: Aging; Animals; Benzylamines; Blood-Brain Barrier; Brain; Cerebral Cortex; Clorgyline; Microcirculation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Inbred Strains; Selegiline; Substrate Specificity; Tryptamines | 1987 |
Ganglioside GM1 causes expression of type B monoamine oxidase in a rat clonal pheochromocytoma cell line, PC12h.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Clorgyline; G(M1) Ganglioside; G(M2) Ganglioside; Kinetics; Kynuramine; Monoamine Oxidase; Nerve Growth Factors; Pheochromocytoma; Rats; Selegiline | 1987 |
Effects of d-methamphetamine on monkey brain monoamine oxidase, in vivo and in vitro.
Topics: Animals; Brain; Clorgyline; Dextroamphetamine; Female; In Vitro Techniques; Macaca fascicularis; Methamphetamine; Mitochondria; Monoamine Oxidase; Selegiline; Synaptosomes | 1987 |
Metabolism of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a rat pheochromocytoma cell line, PC12h.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Clorgyline; Culture Media; Monoamine Oxidase; Neurons; Osmolar Concentration; Pheochromocytoma; Pyridines; Pyridinium Compounds; Rats; Selegiline; Tumor Cells, Cultured | 1987 |
Changes in MAO activities in several organs of rats after administration of l-thyroxine.
Topics: Animals; Brain; Clorgyline; Cytosol; Lung; Male; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Monoamine Oxidase; Rats; Rats, Inbred Strains; Selegiline; Thyroxine | 1987 |
Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Clorgyline; Corpus Striatum; Dopamine; Haplorhini; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neural Pathways; Neurotoxins; Pyridines; Selegiline | 1988 |
Neuropharmacological studies on selective monoamine oxidase A and B inhibitors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Clorgyline; Dogs; Dose-Response Relationship, Drug; Female; Hypnosis, Anesthetic; Male; Mice; Monoamine Oxidase Inhibitors; Nialamide; Nociceptors; Rats; Rats, Inbred Strains; Seizures; Selegiline | 1987 |
Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Clorgyline; Male; Mice; Monoamine Oxidase; Oxidation-Reduction; Pyridines; Selegiline; Structure-Activity Relationship | 1988 |
Possible mechanisms underlying the differential effects of selective inhibitors of type A and type B monoamine oxidase on intraocular pressure in the cat.
Topics: Animals; Cats; Clorgyline; Denervation; Intraocular Pressure; Phenethylamines; Propylamines; Selegiline; Sympathetic Nervous System | 1986 |
[3H]tryptamine binding sites are not identical to monoamine oxidase in rat brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Brain; Clorgyline; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Synaptosomes; Tissue Distribution; Tryptamines | 1988 |
Disposition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice before and after monoamine oxidase and catecholamine reuptake inhibition.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Glands; Animals; Autoradiography; Brain; Catecholamines; Clorgyline; Female; Image Processing, Computer-Assisted; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Pyridines; Scintillation Counting; Selegiline; Tissue Distribution | 1988 |
The depletion of rat cortical norepinephrine and the inhibition of [3H]norepinephrine uptake by xylamine does not require monoamine oxidase activity.
Topics: Allyl Compounds; Animals; Butylamines; Cerebral Cortex; Clorgyline; Desipramine; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitrogen Mustard Compounds; Norepinephrine; Rats; Rats, Inbred Strains; Selegiline; Synaptosomes; Tyrosine | 1988 |
Selective inhibition of MAO-A, not MAO-B, results in antidepressant-like effects on DRL 72-s behavior.
Topics: Animals; Antidepressive Agents; Clorgyline; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Monoamine Oxidase Inhibitors; Pargyline; Piperidines; Rats; Rats, Inbred Strains; Reinforcement Schedule; Selegiline | 1988 |
Reciprocal changes in striatal dopamine and beta-phenylethylamine induced by reserpine in the presence of monoamine oxidase inhibitors.
Topics: Animals; Biogenic Amines; Clorgyline; Corpus Striatum; Dopamine; Male; Mice; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Reserpine; Selegiline | 1988 |
Reversible, enzyme-activated monoamine oxidase inhibitors: new advances.
Topics: Animals; Benzamides; Brain; Clorgyline; Humans; In Vitro Techniques; Male; Moclobemide; Monoamine Oxidase Inhibitors; Phenelzine; Picolinic Acids; Piperidines; Rats; Selegiline | 1988 |
Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the mouse: relationships between monoamine oxidase, MPTP metabolism and neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Benzylamines; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Pyridines; Selegiline; Substantia Nigra; Synaptosomes; Tryptamines | 1985 |
Effects of clorgyline and (-)deprenyl on the deamination of normetanephrine and noradrenaline in strips and homogenates of the canine saphenous vein.
Topics: Animals; Clorgyline; Cocaine; Deamination; Dogs; Hydrocortisone; In Vitro Techniques; Monoamine Oxidase Inhibitors; Norepinephrine; Normetanephrine; Phenethylamines; Propylamines; Saphenous Vein; Selegiline | 1985 |
Influence of MAO A and MAO B on the inactivation of noradrenaline in the saphenous vein of the dog.
Topics: Animals; Clorgyline; Deamination; Dogs; Electric Stimulation; In Vitro Techniques; Monoamine Oxidase; Norepinephrine; Saphenous Vein; Selegiline | 1985 |
An improved fluorimetric assay for brain monoamine oxidase.
Topics: Animals; Brain; Clorgyline; Hydroxyquinolines; Kinetics; Kynuramine; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Selegiline; Spectrometry, Fluorescence | 1985 |
Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors, types A and B, in the cat.
Topics: Amines; Animals; Blood Pressure; Brain; Cats; Clorgyline; Female; Indans; Liver; Male; Monoamine Oxidase Inhibitors; Nictitating Membrane; Phenethylamines; Selegiline; Sympathetic Nervous System; Tyramine | 1985 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correspondence of its binding sites to monoamine oxidase in rat brain, and inhibition of dopamine oxidative deamination in vivo and in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Clorgyline; Corpus Striatum; Deamination; Dopamine; In Vitro Techniques; Male; Monoamine Oxidase; Oxidation-Reduction; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Subcellular Fractions | 1985 |
Guinea pig striatum as a model of human dopamine deamination: the role of monoamine oxidase isozyme ratio, localization, and affinity for substrate in synaptic dopamine metabolism.
Topics: Animals; Clorgyline; Corpus Striatum; Deamination; Dopamine; Guinea Pigs; Humans; Isoenzymes; Kinetics; Macaca mulatta; Male; Models, Neurological; Monoamine Oxidase; Rats; Rats, Inbred Strains; Selegiline; Synapses; Synaptosomes | 1985 |
Studies on the oxidation of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Allylamine; Animals; Benzylamines; Brain; Clorgyline; Indans; Kinetics; Mice; Mice, Inbred C57BL; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Pyridines; Selegiline; Tryptamines | 1985 |
Selective, irreversible in vivo binding of [11C]clorgyline and [11C]-L-deprenyl in mice: potential for measurement of functional monoamine oxidase activity in brain using positron emission tomography.
Topics: Animals; Brain; Carbon Radioisotopes; Clorgyline; Male; Mice; Monoamine Oxidase; Phenethylamines; Propylamines; Protein Binding; Radioligand Assay; Selegiline; Tomography, Emission-Computed | 1985 |
Purification and properties of mitochondrial monoamine oxidase type A from human placenta.
Topics: 2,2'-Dipyridyl; Amphetamine; Animals; Cattle; Chromatography; Clorgyline; Disulfides; Electrophoresis, Polyacrylamide Gel; Female; Flavins; Humans; Kinetics; Mitochondria; Molecular Weight; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Placenta; Pregnancy; Selegiline; Solubility; Sulfhydryl Compounds | 1985 |
Down-regulation of [3H]5-hydroxytryptamine binding sites in chick embryo brain by monoamine oxidase inhibitors or fenfluramine and potentiation by d,l-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Animals; Binding Sites; Brain; Chick Embryo; Clorgyline; Fenfluramine; Mice; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline; Serotonin | 1985 |
Interactions between relatively selective monoamine oxidase inhibitors and an inhibitor of 5-hydroxytryptamine re-uptake, clomipramine.
Topics: Animals; Arrhythmias, Cardiac; Body Temperature; Cerebral Cortex; Clomipramine; Clorgyline; Drug Interactions; Hyperthermia, Induced; Male; Monoamine Oxidase Inhibitors; Motor Activity; Myoclonus; Rats; Selegiline | 1985 |
Histochemical localization of monoamine oxidase types A and B in the adrenal gland.
Topics: Adrenal Cortex; Adrenal Glands; Adrenal Medulla; Animals; Cats; Cattle; Clorgyline; Dogs; Histocytochemistry; Monoamine Oxidase; Pargyline; Phenethylamines; Rats; Selegiline; Serotonin; Species Specificity; Substrate Specificity | 1985 |
The effect of lipid-depletion on the kinetic properties of rat liver monoamine oxidase-B.
Topics: Animals; Butanones; Clorgyline; In Vitro Techniques; Kinetics; Lipids; Mitochondria, Liver; Monoamine Oxidase; Rats; Selegiline | 1980 |
Some factors influencing the metabolism of benzylamine by type A and B monoamine oxidase in rat heart and liver.
Topics: Amines; Animals; Benzylamines; Clorgyline; Deamination; Kinetics; Liver; Male; Monoamine Oxidase; Myocardium; Rats; Selegiline; Substrate Specificity | 1980 |
Monoamine oxidase in frog liver and brain.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Liver; Monoamine Oxidase; Proteins; Rana catesbeiana; Selegiline | 1981 |
Postnatal development of dopaminergic neurons in the rabbit retina.
Topics: Aging; Animals; Animals, Newborn; Benzylamines; Clorgyline; Dopamine; Kinetics; Monoamine Oxidase; Neurons; Potassium; Rabbits; Retina; Selegiline; Tyrosine 3-Monooxygenase | 1981 |
Effects of inhibitors of monoamine oxidase activity in goldfish (Carassius auratus) brain in vitro.
Topics: Animals; Brain; Clorgyline; Cyprinidae; Goldfish; Harmaline; In Vitro Techniques; Kinetics; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Time Factors | 1981 |
The kinetics of inhibition of type-B monoamine oxidase by clorgyline, pargyline and (-)-deprenyl.
Topics: Animals; Clorgyline; In Vitro Techniques; Kinetics; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline | 1981 |
Effects of inhibitors on monoamine oxidase activity in perch (Perca flavescens) brain in vitro.
Topics: Animals; Brain; Clorgyline; Female; Fishes; Harmaline; Hydroxyquinolines; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Selegiline; Time Factors | 1982 |
Monoamine oxidase activity in several tissues of the goldfish. Carassius auratus.
Topics: Animals; Clorgyline; Cyprinidae; Goldfish; Harmaline; In Vitro Techniques; Kinetics; Male; Monoamine Oxidase; Selegiline | 1982 |
Some characteristics of monoamine oxidase activity in tissues of the adult female grassfrog (Rana pipiens).
Topics: Animals; Clorgyline; Female; Harmaline; Kinetics; Kynuramine; Monoamine Oxidase; Rana pipiens; Selegiline | 1982 |
Metabolism of the monoamine oxidase-B inhibitor, MD 780236 and its enantiomers by the A and B forms of the enzyme in the rat.
Topics: Animals; Biotransformation; Brain; Clorgyline; In Vitro Techniques; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Inbred Strains; Selegiline; Stereoisomerism | 1983 |
On the substrate specificities of the two forms of monoamine oxidase.
Topics: Animals; Clorgyline; Dopamine; Kinetics; Liver; Male; Monoamine Oxidase; Rats; Rats, Inbred Strains; Selegiline; Substrate Specificity | 1984 |
Some properties of monoamine oxidase in carp heart.
Topics: Animals; Carps; Clorgyline; Cyprinidae; In Vitro Techniques; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Muscle Proteins; Myocardium; Selegiline; Substrate Specificity | 1984 |
Occurrence of type A and type B monoamine oxidase activities in toad egg mitochondria.
Topics: Animals; Bufo bufo; Clorgyline; Female; Isoenzymes; Mercaptoethanol; Mitochondria; Monoamine Oxidase; Ovum; Phenethylamines; Selegiline; Serotonin; Substrate Specificity | 1984 |
Histochemical investigation of criteria for the distinction between monoamine oxidase A and B in various species.
Topics: Animals; Cats; Clorgyline; Ganglia, Sympathetic; Histocytochemistry; Horseradish Peroxidase; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pineal Gland; Rabbits; Rats; Selegiline; Species Specificity; Staining and Labeling; Tetrazolium Salts | 1984 |
Effects of clorgyline and deprenil on corticosterone levels in rats.
Topics: Adrenal Glands; alpha-Methyltyrosine; Animals; Clorgyline; Corticosterone; Fenclonine; Methyltyrosines; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Rats; Selegiline | 1982 |
Mechanism of serotonin effects on prolactin and growth hormone secretion in domestic fowl.
Topics: alpha-Methyltyrosine; Animals; Brain; Chickens; Clorgyline; Fenclonine; Growth Hormone; Imipramine; Male; Methyltyrosines; Pargyline; Prolactin; Receptors, Serotonin; Selegiline; Serotonin; Tryptophan | 1983 |
Cardiovascular effects of intracerebroventricular injection of dopamine after selective MAO inhibition in rats.
Topics: Animals; Blood Pressure; Clorgyline; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Heart Rate; Injections, Intravenous; Male; Monoamine Oxidase Inhibitors; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Selegiline | 1982 |
Mechanism of the involvement of monoamine oxidase in the regulation of (Na+ + K+)-ATPase in rat brain.
Topics: Animals; Brain; Clorgyline; Dopamine; Flavoring Agents; Monoamine Oxidase; Rats; Rats, Inbred Strains; Selegiline; Sodium-Potassium-Exchanging ATPase; Tissue Distribution | 1983 |
Effect of selective monoamine oxidase inhibition by clorgyline and deprenyl on the norepinephrine receptor-coupled adenylate cyclase system in rat cortex.
Topics: Adenylyl Cyclases; Animals; Cerebral Cortex; Clorgyline; Cyclic AMP; Dihydroalprenolol; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Selegiline | 1983 |
The metabolism of dopamine by both forms of monoamine oxidase in the rat brain and its inhibition by cimoxatone.
Topics: Aging; Animals; Brain; Clorgyline; Dopamine; Isoenzymes; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Inbred Strains; Selegiline; Species Specificity | 1983 |
Effect of lipid depletion and solubilization on inhibitor sensitivity of mitochondrial monoamine oxidase.
Topics: Animals; Carps; Clorgyline; In Vitro Techniques; Kinetics; Lipids; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Octoxynol; Polyethylene Glycols; Selegiline | 1983 |
Long-lasting, true aphrodisiac effect of (-)-deprenyl in sexually sluggish old male rats.
Topics: Aging; Amphetamine; Animals; Aphrodisiacs; Castration; Clorgyline; Copulation; Male; Phenethylamines; Rats; Selegiline; Sexual Behavior, Animal; Time Factors | 1983 |
Studies of the type A and type B monoamine oxidase. A new approach to their development and subcellular localization.
Topics: Acetylcholinesterase; Animals; Astrocytes; Catechol O-Methyltransferase; Cells, Cultured; Clorgyline; Mice; Monoamine Oxidase Inhibitors; Neuroglia; Rats; Selegiline; Subcellular Fractions; Synaptosomes | 1983 |
Clinical and laboratory studies with selective monoamine-oxidase-inhibiting drugs. Implications for hypothesized neurotransmitter changes associated with depression and antidepressant drug effects.
Topics: Behavior; Biogenic Amines; Clorgyline; Depressive Disorder; Dopamine; Histamine; Humans; Monoamine Oxidase Inhibitors; Norepinephrine; Pargyline; Phenethylamines; Selegiline; Serotonin; Tyramine | 1983 |
Partial or total protection from long-acting monoamine oxidase inhibitors (MAOIs) by new short-acting MAOIs of type A MD780515 and type B MD780236.
Topics: Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; Female; Liver; Male; Monoamine Oxidase Inhibitors; Myocardium; Oxazoles; Oxazolidinones; Rats; Rats, Inbred Strains; Selegiline; Tranylcypromine | 1983 |
The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions.
Topics: Brain; Clorgyline; Deamination; Dopamine; Female; Humans; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Selegiline; Serotonin | 1983 |
[Effect of protein denaturing reactions on retardation of the activity of rat liver mitochondrial monoamine oxidase by clorgyline and deprenyl].
Topics: Animals; Clorgyline; Dose-Response Relationship, Drug; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Protein Denaturation; Rats; Selegiline; Serotonin; Tyramine; Urea | 1983 |
Tyramine and depressive illness.
Topics: Animals; Clorgyline; Depressive Disorder; Humans; Phenotype; Rats; Selegiline; Tyramine | 1983 |
Behavioural hyperactivity in rats treated with selective monoamine oxidase inhibitors and LM 5008, a selective 5-hydroxytryptamine uptake blocker.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Clorgyline; Drug Combinations; Male; Monoamine Oxidase Inhibitors; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Selegiline; Tranylcypromine | 1983 |
Tyramine-induced noradrenaline release from rat brain slices: prevention by (-)-deprenyl.
Topics: Animals; Cerebral Cortex; Clorgyline; Drug Interactions; Female; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Phenethylamines; Rats; Selegiline; Stereoisomerism; Tritium; Tyramine | 1983 |
Monoamine oxidase in pancreatic islets, exocrine pancreas, and liver from rats. Characterization with clorgyline, deprenyl, pargyline, tranylcypromine, and amezinium.
Topics: Animals; Clorgyline; Female; Insulin; Insulin Secretion; Islets of Langerhans; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pancreas; Pargyline; Pyridazines; Rats; Rats, Inbred Strains; Selegiline; Tranylcypromine | 1983 |
Thermal inactivation of mouse brain monoamine oxidase type A and type B.
Topics: Animals; Brain; Clorgyline; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Male; Mice; Mice, Inbred CBA; Monoamine Oxidase; Protein Denaturation; Selegiline | 1983 |
Isoelectric focusing of isoenzymes of monkey brain monoamine oxidase.
Topics: Animals; Brain; Clorgyline; Haplorhini; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoenzymes; Monoamine Oxidase; Selegiline | 1984 |
Isolated chromaffin cells from adrenal medulla contain primarily monoamine oxidase B.
Topics: Adrenal Medulla; Animals; Blood Platelets; Catecholamines; Cattle; Chromaffin System; Clorgyline; Humans; Monoamine Oxidase; Norepinephrine; Selegiline; Serotonin | 1984 |
Some interrelated properties of A and B form monoamine oxidase in monkey brain mitochondria.
Topics: Animals; Brain; Clorgyline; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Macaca; Mitochondria; Monoamine Oxidase; Nerve Tissue Proteins; Selegiline | 1984 |
Monoamine oxidase inhibitors and their pharmacological significance.
Topics: Animals; Antidepressive Agents; Brain; Clorgyline; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Phenethylamines; Rats; Selegiline; Tyramine | 1983 |
Effect of nonselective and selective inhibitors of monoamine oxidases A and B on pethidine toxicity in mice.
Topics: Animals; Brain Chemistry; Clorgyline; Drug Interactions; Female; Lethal Dose 50; Male; Meperidine; Mice; Monoamine Oxidase Inhibitors; Selegiline; Serotonin | 1984 |
Characteristics of mitochondrial and synaptosomal monoamine oxidase in monkey brain.
Topics: Animals; Brain; Cattle; Clorgyline; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Macaca; Mice; Mitochondria; Monoamine Oxidase; Nerve Tissue Proteins; Phenethylamines; Rabbits; Rats; Selegiline; Serotonin; Species Specificity; Substrate Specificity; Synaptosomes; Tyramine | 1984 |
The amine oxidase of human blood lymphocytes and granulocytes.
Topics: Benzylamine Oxidase; Clorgyline; Granulocytes; Humans; Kinetics; Lymphocytes; Monoamine Oxidase; Selegiline | 1983 |
A new method for in vivo measurement of brain monoamine oxidase activity.
Topics: 2-Hydroxyphenethylamine; Animals; Brain; Clorgyline; Isoenzymes; Male; Methylamines; Mice; Mice, Inbred C3H; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Substrate Specificity | 1984 |
Localization and identification of covalently bound flavoproteins in rat liver mitochondria by prelabeling of their flavin moiety.
Topics: Animals; Benzylamines; Carbon Radioisotopes; Clorgyline; Flavoproteins; Male; Mitochondria, Liver; Molecular Weight; Monoamine Oxidase; Oxidoreductases, N-Demethylating; Pargyline; Protein Binding; Rats; Rats, Inbred Strains; Riboflavin; Sarcosine Dehydrogenase; Selegiline; Serotonin; Tritium; Tyramine | 1984 |
Properties of monoamine oxidase in monkey heart.
Topics: Animals; Anura; Clorgyline; Drug Resistance; Humans; In Vitro Techniques; Kinetics; Macaca fascicularis; Mitochondria, Heart; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Muscle Proteins; Myocardium; Rats; Selegiline; Semicarbazides; Substrate Specificity | 1984 |
Release of endogenous dopamine from rat isolated striatum: effect of clorgyline and (-)-deprenyl.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dopamine; In Vitro Techniques; Monoamine Oxidase; Phenethylamines; Propylamines; Rats; Rats, Inbred Strains; Selegiline; Time Factors | 1984 |
On-line radiochemical assay for monoamine oxidase utilizing high-performance liquid chromatography.
Topics: Animals; Benzylamines; Brain; Chromatography, High Pressure Liquid; Clorgyline; Indicators and Reagents; Kinetics; Male; Mitochondria; Monoamine Oxidase; Radiochemistry; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1984 |
Evidence for the presence of two types of monoamine oxidase in rabbit choroid plexus and their role in breakdown of amines influencing cerebrospinal fluid formation.
Topics: Animals; Cerebrospinal Fluid; Choroid Plexus; Clorgyline; Female; Isoenzymes; Male; Monoamine Oxidase; Nialamide; Norepinephrine; Rabbits; Selegiline | 1980 |
Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Benzofurans; Carbolines; Citalopram; Clomipramine; Clorgyline; Fluoxetine; Harmine; Indoles; Methoxydimethyltryptamines; Mice; Mice, Inbred DBA; N,N-Dimethyltryptamine; Pargyline; Propylamines; Quipazine; Seizures; Selegiline | 1980 |
Monoamine oxidase substrates and substrate affinity.
Topics: Animals; Biotransformation; Cerebral Cortex; Clorgyline; Histamine; Hypothalamus; Isoenzymes; Molecular Conformation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Selegiline; Substrate Specificity | 1980 |
Monoacylcadaverines as substrates for both monoamine oxidase and diamine oxidase; low rates of activity.
Topics: Amine Oxidase (Copper-Containing); Animals; Cadaverine; Clorgyline; Diamines; Kidney; Kinetics; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Rats; Selegiline; Substrate Specificity; Swine | 1980 |
Titration of human brain monoamine oxidase -A and -B by clorgyline and L-deprenil.
Topics: Adult; Aged; Aging; Benzylamines; Brain; Cerebral Cortex; Child, Preschool; Clorgyline; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Monoamine Oxidase; Nerve Tissue Proteins; Phenethylamines; Propylamines; Selegiline; Serotonin | 1980 |
Serotonin oxidation by type B MAO of rat brain.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Rats; Selegiline; Serotonin | 1980 |
Monoamine oxidase inhibitors and histamine metabolism.
Topics: Animals; Clorgyline; Histamine; Iproniazid; Male; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Selegiline; Tranylcypromine | 1980 |
Inhibition of monoamine oxidase by d-methamphetamine.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Methamphetamine; Mitochondria; Monoamine Oxidase Inhibitors; Phenethylamines; Rats; Selegiline; Serotonin; Tyramine | 1980 |
The inhibition of tyramine oxidation and the tyramine hypertensive response ("cheese effect") may be independent phenomena.
Topics: Animals; Blood Pressure; Clorgyline; Hypertension; Liver; Male; Monoamine Oxidase; Phenethylamines; Propylamines; Selegiline; Swine; Tissue Distribution; Tyramine | 1980 |
Characterization of N-methylphenylethylamine and N-methylphenylethanolamine as substrates for type A and type B monoamine oxidase.
Topics: 2-Hydroxyphenethylamine; Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Methamphetamine; Mitochondria; Monoamine Oxidase; Nerve Tissue Proteins; Phenethylamines; Rats; Selegiline | 1980 |
The monoamine oxidase inhibitors clorgyline and L-deprenyl also affect the uptake of dopamine, noradrenaline and serotonin by rat brain synaptosomal preparations.
Topics: Animals; Brain; Clorgyline; Dopamine; Male; Nialamide; Norepinephrine; Phenethylamines; Propylamines; Rats; Selegiline; Serotonin; Subcellular Fractions; Synaptosomes | 1980 |
Inhibition of monoamine oxidase by clorgyline and deprenyl in circumventricular structures of rat brain.
Topics: Animals; Brain; Cerebral Ventricles; Clorgyline; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Rats; Selegiline; Serotonin; Tyramine | 1980 |
Substrate selectivity of type A and type B monoamine oxidase in rat brain.
Topics: Animals; Brain; Clorgyline; Isoenzymes; Kinetics; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Selegiline; Substrate Specificity | 1980 |
Studies on the subcellular localization of monoamine oxidase types A and B and its importance for the deamination of dopamine in the rat brain.
Topics: Animals; Brain; Clorgyline; Deamination; Dopamine; In Vitro Techniques; Kinetics; Mitochondria; Monoamine Oxidase; Rats; Selegiline; Subcellular Fractions; Synaptosomes | 1980 |
Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain.
Topics: Animals; Brain; Caudate Nucleus; Cerebral Cortex; Chlorocebus aethiops; Clorgyline; Deamination; Dopamine; Female; Humans; Macaca mulatta; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Rats; Selegiline; Serotonin; Species Specificity; Substrate Specificity; Tyramine | 1980 |
Identification of type A monoamine oxidase in mouse and rabbit liver mitochondria.
Topics: Animals; Clorgyline; Dose-Response Relationship, Drug; Male; Mice; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rabbits; Selegiline; Serotonin; Substrate Specificity | 1981 |
Studies on the pargyline-binding site of different types of monoamine oxidase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Clorgyline; Female; Humans; In Vitro Techniques; Liver; Male; Monoamine Oxidase; Pargyline; Peptide Hydrolases; Pregnancy; Rats; Selegiline; Tissue Distribution | 1981 |
Biochemical characterization of the active site of brain monoamine oxidase.
Topics: Antidepressive Agents; Binding Sites; Brain; Clorgyline; Humans; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Binding; Selegiline; Substrate Specificity; Tissue Distribution | 1980 |
[Mechanism of inhibition by chlorgyline and deprenyl of tyramine deamination by mitochondrial monoamine oxidase of rat liver].
Topics: Animals; Binding, Competitive; Clorgyline; Enzyme Activation; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Protein Binding; Rats; Selegiline; Tyramine | 1980 |
Specificity of endogenous substrates for types A and B monoamine oxidase in rat striatum.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Isoenzymes; Kinetics; Male; Monoamine Oxidase; Phenethylamines; Rats; Selegiline; Serotonin; Substrate Specificity; Tyramine | 1981 |
The regional distribution of monoamine oxidase activities towards different substrates: effects in rat brain of chronic administration of manganese chloride and of ageing.
Topics: Aging; Animals; Benzylamines; Brain; Chlorides; Clorgyline; Dopamine; Female; Male; Manganese; Manganese Compounds; Monoamine Oxidase; Rats; Selegiline; Serotonin; Tissue Distribution | 1981 |
Alteration of dopamine synthesis in rat striatum subsequent to selective type A monoamine oxidase inhibition.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Feedback; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Rats; Selegiline | 1981 |
Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B.
Topics: Animals; Blood Pressure; Clorgyline; In Vitro Techniques; Indans; Indenes; Male; Metaraminol; Monoamine Oxidase Inhibitors; Neurons; Octopamine; Rats; Selegiline; Tyramine; Vas Deferens | 1981 |
The sensitivity of cortical neurons to serotonin: effect of chronic treatment with antidepressants, serotonin-uptake inhibitors and monoamine-oxidase-blocking drugs.
Topics: Animals; Benzofurans; Cerebral Cortex; Clomipramine; Clorgyline; Desipramine; Electric Conductivity; gamma-Aminobutyric Acid; Male; Monoamine Oxidase Inhibitors; Neurons; Piperidines; Rats; Selegiline; Serotonin; Serotonin Antagonists | 1981 |
Potentiation by deprenil of 1-dopa induced circling in nigral-lesioned rats.
Topics: Animals; Clorgyline; Dopamine; Humans; Hydroxydopamines; Isomerism; Levodopa; Male; Oxidopamine; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Stereotyped Behavior; Substantia Nigra | 1981 |
Type A monoamine oxidase catalyzes the intraneuronal deamination of dopamine within nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophyseal neurons in the rat.
Topics: Animals; Brain; Catecholamines; Clorgyline; Corpus Striatum; Dopamine; Hypothalamo-Hypophyseal System; Male; Median Eminence; Monoamine Oxidase; Neurons; Nialamide; Norepinephrine; Olfactory Bulb; Pituitary Gland, Posterior; Prolactin; Rats; Rats, Inbred Strains; Selegiline | 1981 |
[Effect of solubilization by methylethylketone of rat liver mitochondrial monoamine oxidase on inhibition by clorgyline and deprenyl of the enzyme activity].
Topics: Animals; Butanones; Clorgyline; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase; Phenethylamines; Propylamines; Rats; Selegiline; Solubility; Substrate Specificity | 1981 |
Preferential inhibition of the B-form of monoamine oxidase in the liver of rats given 3'-methyl-4-dimethylaminoazobenzene in the diet.
Topics: Animals; Clorgyline; Diet; Kinetics; Male; Methyldimethylaminoazobenzene; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; p-Dimethylaminoazobenzene; Pargyline; Rats; Selegiline | 1982 |
Effects of inhibitors on monoamine oxidase activity in mouse brain.
Topics: Animals; Brain; Clorgyline; Harmaline; Kinetics; Kynuramine; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline | 1982 |
Inhibition of rabbit liver monoamine oxidase by nitro aromatic compounds.
Topics: Aniline Compounds; Animals; Benzylamines; Chemical Phenomena; Chemistry; Clorgyline; Female; Kinetics; Liver; Monoamine Oxidase Inhibitors; Nitro Compounds; Rabbits; Selegiline | 1982 |
Role of type A and type B monoamine oxidase in the metabolism of released [3H]dopamine from rat striatal slices.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Male; Monoamine Oxidase; Nomifensine; Potassium; Rats; Rats, Inbred Strains; Selegiline | 1982 |
5-hydroxytryptamine: a substrate for rat liver mitochondrial monoamine oxidase-A and -B.
Topics: Animals; Clorgyline; Dose-Response Relationship, Drug; Mitochondria, Liver; Monoamine Oxidase; Oxidation-Reduction; Rats; Selegiline; Serotonin | 1982 |
The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline.
Topics: Animals; Clorgyline; Kinetics; Liver; Male; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenethylamines; Propylamines; Proteins; Rats; Rats, Inbred Strains; Selegiline; Serotonin | 1982 |
Benzylamine oxidase activity in rat embryo and placenta at organogenesis.
Topics: Animals; Benzylamine Oxidase; Clorgyline; Embryo, Mammalian; Female; Gestational Age; Monoamine Oxidase; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Selegiline; Substrate Specificity | 1982 |
Clorgyline and deprenyl insensitive monoamine oxidase in rat brain soluble fraction.
Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Monoamine Oxidase; Phenethylamines; Propylamines; Rats; Selegiline; Subcellular Fractions | 1982 |
Plasma 5-hydroxyindoleacetic acid as an indicator of monoamine oxidase-A inhibition in rat brain and peripheral tissues.
Topics: Animals; Biomarkers; Brain; Chromatography, High Pressure Liquid; Clorgyline; Hydroxyindoleacetic Acid; Isoenzymes; Kinetics; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Wistar; Selegiline; Serotonin; Tranylcypromine | 1993 |
1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol depletes catecholamines in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cerebral Ventricles; Clorgyline; Corpus Striatum; Dopamine; Functional Laterality; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypothalamus; Infusions, Parenteral; Isoquinolines; Locus Coeruleus; Male; Microinjections; Norepinephrine; Organ Specificity; Raphe Nuclei; Rats; Rats, Wistar; Selegiline; Serotonin; Stereotaxic Techniques; Substantia Nigra; Thalamus | 1993 |
Striatal dopamine participates in glutamate-induced hydroxyl radical generation.
Topics: Animals; Clorgyline; Dopamine; Glutamic Acid; Hydroxyl Radical; Male; Microdialysis; Neostriatum; Rats; Rats, Sprague-Dawley; Salicylates; Selegiline | 1995 |
Influence of selective inhibition of monoamine oxidase A or B on striatal metabolism of L-DOPA in hemiparkinsonian rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dialysis; Dopamine; Homovanillic Acid; Indans; Levodopa; Male; Monoamine Oxidase Inhibitors; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra | 1995 |
Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion.
Topics: Cell Compartmentation; Cerebral Cortex; Clorgyline; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Neurotoxins; Oxidation-Reduction; Selegiline; Semicarbazides | 1995 |
Monoamine oxidase inhibitors increase preferentially extracellular 5-hydroxytryptamine in the midbrain raphe nuclei. A brain microdialysis study in the awake rat.
Topics: Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Clorgyline; Dialysis; Extracellular Space; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; Raphe Nuclei; Rats; Rats, Wistar; Selegiline; Serotonin; Tranylcypromine | 1993 |
Influence of monoamine oxidase inhibitors on striatonigral dynorphin system: a study with deprenyl and clorgyline.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Dynorphins; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selegiline; Serotonin; Substantia Nigra | 1993 |
Responses of forebrain neurons to the MAO-B blocker L-deprenyl.
Topics: Acetylcholine; Amphetamine; Animals; Clorgyline; Electrophoresis; Female; gamma-Aminobutyric Acid; Macaca mulatta; Male; Microelectrodes; Monoamine Oxidase; Neurons; Prosencephalon; Rats; Rats, Inbred Strains; Selegiline; Species Specificity | 1995 |
Age-dependent effects of the 2'-methyl analog of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine: prevention by inhibitors of monoamine oxidase B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Clorgyline; Corpus Striatum; Dopamine; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Selegiline | 1995 |
Evaluation of radioiodinated iodoclorgyline as a SPECT radiopharmaceutical for MAO-A in the brain.
Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Clorgyline; Iodine Radioisotopes; Isoenzymes; Male; Mice; Mice, Inbred Strains; Mitochondria; Monoamine Oxidase; Radioligand Assay; Selegiline; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 1995 |
Thyroid iodide transport is reduced by administration of monoamine oxidase A inhibitors to rats.
Topics: Animals; Biological Transport; Clorgyline; Iodides; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organ Culture Techniques; Pargyline; Rats; Rats, Wistar; Selegiline; Thyroid Gland; Tranylcypromine | 1994 |
Effects of gestational exposure to monoamine oxidase inhibitors in rats: preliminary behavioral and neurochemical studies.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Brain; Brain Chemistry; Catalepsy; Clorgyline; Female; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Agents; Postural Balance; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Selegiline; Sex Characteristics; Smell | 1994 |
1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol inhibits tyrosine hydroxylase activity in rat striatal synaptosomes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dopamine; Isoquinolines; Monoamine Oxidase; NAD; Nerve Tissue Proteins; Nomifensine; Parkinson Disease; Rats; Selegiline; Sulpiride; Synaptosomes; Tyrosine 3-Monooxygenase | 1994 |
Inhibition by (-)-deprenyl of agonist-evoked contractions in rabbit aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Clorgyline; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Histamine H1 Antagonists; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pargyline; Phenylephrine; Potassium; Rabbits; Selegiline; Serotonin Antagonists | 1994 |
Interactions among deprenyl, clorgyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on catecholamines in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Catecholamines; Clorgyline; Dopamine; Dopamine Agents; Drug Interactions; Hippocampus; Male; Mice; Mice, Inbred BALB C; MPTP Poisoning; Neostriatum; Norepinephrine; Selegiline; Serotonin | 1994 |
Effects of monoamine oxidase inhibitors and dopamine agonists on the behavior of mammal- and frog-eating snakes.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Appetitive Behavior; Clorgyline; Colubridae; Dopamine Agents; Dose-Response Relationship, Drug; Feeding Behavior; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Receptors, Dopamine; Receptors, Dopamine D1; Selegiline; Snakes; Species Specificity; Stereotyped Behavior | 1994 |
Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity.
Topics: Ascorbic Acid; Clorgyline; Dopamine; Dopamine Agents; Dopamine Antagonists; Hydroxyl Radical; Melanins; Monoamine Oxidase Inhibitors; Nervous System; Oxidation-Reduction; Pargyline; Selegiline | 1994 |
The MAO-B inhibitor deprenyl, but not the MAO-A inhibitor clorgyline, potentiates the neurotoxicity of p-chloroamphetamine.
Topics: Animals; Autoradiography; Body Temperature; Brain; Clorgyline; Drug Synergism; Iodocyanopindolol; Male; Nerve Endings; Nervous System Diseases; Neurons; p-Chloroamphetamine; Pargyline; Pindolol; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selegiline; Serotonin | 1994 |
Quantitative distribution of rat brain monoamine oxidase A by [14C]clorgyline autoradiography.
Topics: Animals; Autoradiography; Brain; Clorgyline; Isotope Labeling; Male; Monoamine Oxidase; Rats; Rats, Sprague-Dawley; Selegiline | 1994 |
Enhancement of striatal lipid peroxidation induced by 1-methyl-4-phenylpyridinium in mouse brain is blocked by MAO-B inhibitors.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Clorgyline; Lipid Peroxidation; Male; Mice; Monoamine Oxidase Inhibitors; Neostriatum; Pargyline; Selegiline | 1994 |
Heterogeneity of monoamine oxidase activities in synaptic and non-synaptic mitochondria derived from three brain regions: some functional implications.
Topics: Animals; Brain; Cell Fractionation; Cerebral Cortex; Clorgyline; Corpus Striatum; Dopamine; Male; Medulla Oblongata; Mitochondria; Monoamine Oxidase; Pons; Rats; Rats, Wistar; Selegiline; Synapses | 1994 |
Integrative transporter-mediated release from cytoplasmic and vesicular 5-hydroxytryptamine stores in cultured neurons.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Stem; Carrier Proteins; Cells, Cultured; Clorgyline; Female; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurons; Nimodipine; p-Chloroamphetamine; Pregnancy; Rats; Rats, Sprague-Dawley; Reserpine; Selegiline; Serotonin; Serotonin Plasma Membrane Transport Proteins | 1993 |
The histochemical demonstration of MPTP oxidation in the postmortem human striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Caudate Nucleus; Cerebrovascular Disorders; Clorgyline; Corpus Striatum; Dopamine Agents; Female; Glial Fibrillary Acidic Protein; Histocytochemistry; Humans; Male; Monoamine Oxidase; Neuroglia; Oxidation-Reduction; Putamen; Selegiline | 1993 |
Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver.
Topics: Clorgyline; Female; Humans; Liver; Male; Monoamine Oxidase; NADP; Selegiline; Sumatriptan | 1994 |
4-Dimethylaminophenethylamine, a sensitive, specific, electrochemically detectable monoamine oxidase-B substrate.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Clorgyline; Kinetics; Male; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Phenethylamines; Phenylacetates; Rats; Selegiline | 1994 |
L-3,4-dihydroxyphenylalanine-induced dopamine release in the striatum of intact and 6-hydroxydopamine-treated rats: differential effects of monoamine oxidase A and B inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Levodopa; Male; Monoamine Oxidase Inhibitors; Nerve Endings; Oxidopamine; Picolinic Acids; Rats; Rats, Sprague-Dawley; Selegiline | 1994 |
L-deprenyl confers specific protection against MPTP-induced Parkinson's disease-like movement disorder in the goldfish.
Topics: Animals; Brain; Clorgyline; Disease Models, Animal; Dopamine; Goldfish; Monoamine Oxidase; Motor Activity; MPTP Poisoning; Norepinephrine; Parkinson Disease, Secondary; Selegiline | 1993 |
Monoamine oxidase inhibitors and the cheese effect.
Topics: Animals; Biological Transport; Cheese; Clorgyline; Diet; Drug Interactions; Humans; Hypertension; Intestinal Mucosa; Intestines; Monoamine Oxidase Inhibitors; Rats; Selegiline; Tyramine | 1993 |
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors | 1993 |
Effect of orthotopic liver transplantation and chemical denervation of the liver on the activities of hepatic monoamine oxidase and catechol-O-methyltransferase.
Topics: Animals; Catechol O-Methyltransferase; Clorgyline; Isoenzymes; Liver; Liver Transplantation; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Lew; Reference Values; Selegiline; Substrate Specificity; Sympathectomy, Chemical | 1993 |
MAO-A and -B inhibitors selectively alter Xenopus mucus-induced behaviors of snakes.
Topics: Analysis of Variance; Animals; Behavior, Animal; Clorgyline; Disease Models, Animal; Movement Disorders; Mucus; Selegiline; Snakes; Xenopus laevis | 1993 |
Different effects of 1-methyl-4-phenyl-pyridinium (MPP+) on monoamine oxidase of dopaminergic terminals in caudate nucleus slices from pigmented and from albino rabbits.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Caudate Nucleus; Clorgyline; Dopamine; Female; In Vitro Techniques; Kinetics; Male; Melanins; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Endings; Pigmentation; Rabbits; Selegiline; Serotonin; Tritium | 1993 |
Identification of a region important for human monoamine oxidase B substrate and inhibitor selectivity.
Topics: Base Sequence; Binding Sites; Cloning, Molecular; Clorgyline; Gene Expression; Humans; Isoenzymes; Kinetics; Liver; Mitochondria; Molecular Sequence Data; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Recombinant Fusion Proteins; Restriction Mapping; Saccharomyces cerevisiae; Selegiline | 1996 |
Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells.
Topics: Adenylyl Cyclases; Adrenergic Uptake Inhibitors; Catecholamines; Cell Death; Clorgyline; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Imipramine; Indoles; Isoquinolines; L-Lactate Dehydrogenase; Monoamine Oxidase Inhibitors; Neuroblastoma; Neurotoxins; Nitroprusside; Receptors, Muscarinic; Selegiline; Tumor Cells, Cultured | 1995 |
GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline.
Topics: 4-Aminobutyrate Transaminase; Animals; Antidepressive Agents; Brain; Clorgyline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Premedication; Rats; Rats, Sprague-Dawley; Selegiline; Tranylcypromine | 1995 |
Inactivation of cytochrome P4502B1 by the monoamine oxidase inhibitors R-(-)-deprenyl and clorgyline.
Topics: Animals; Clorgyline; Cytochrome P-450 CYP2B1; Male; Microsomes, Liver; Monoamine Oxidase Inhibitors; NADP; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Selegiline | 1996 |
Activities of monoamine oxidase-A and -B in adult rat cerebellum following neonatal X-irradiation.
Topics: Age Factors; Animals; Animals, Newborn; Cerebellum; Clorgyline; Female; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Rats; Rats, Wistar; Selegiline | 1996 |
The role of monoamine metabolism in oxidative glutamate toxicity.
Topics: Amines; Animals; Cells, Cultured; Clorgyline; Dose-Response Relationship, Drug; Glutamic Acid; Mice; Mice, Inbred Strains; Monoamine Oxidase; Selegiline | 1996 |
Electrophysiological effects of monoamine oxidase inhibition on rat midbrain dopaminergic neurones: an in vitro study.
Topics: Animals; Clorgyline; Dopamine; Dopamine Antagonists; Electrophysiology; Evoked Potentials; In Vitro Techniques; Mesencephalon; Monoamine Oxidase Inhibitors; Neurons; Pargyline; Patch-Clamp Techniques; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Ventral Tegmental Area | 1996 |
Effect of long-term treatment with selective monoamine oxidase A and B inhibitors on dopamine release from rat striatum in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Drug Administration Schedule; Homovanillic Acid; Indans; Isoenzymes; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Time Factors | 1996 |
Studies on the mechanism of p-chloroamphetamine neurotoxicity.
Topics: Animals; Brain; Clorgyline; Dopamine; Fever; Hydroxyindoleacetic Acid; Indans; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Neurotoxins; p-Chloroamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Agents | 1996 |
Monoamine oxidase-dependent metabolism of dopamine in the striatum and substantia nigra of L-DOPA-treated monkeys.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Dopamine Agents; Female; Isoenzymes; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Saimiri; Selegiline; Substantia Nigra | 1996 |
Modulation of tyrosine hydroxylase and aromatic L-amino acid decarboxylase after inhibiting monoamine oxidase-A.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Clorgyline; Male; Mice; Monoamine Oxidase Inhibitors; Selegiline; Tyrosine 3-Monooxygenase | 1996 |
Preferential localization of monoamine oxidase type A activity in neurons of the locus coeruleus and type B activity in neurons of the dorsal raphe nucleus of the rat: a detailed enzyme histochemical study.
Topics: Animals; Clorgyline; Histocytochemistry; Isoenzymes; Locus Coeruleus; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selegiline | 1997 |
Monoamine oxidase inhibition causes a long-term prolongation of the dopamine-induced responses in rat midbrain dopaminergic cells.
Topics: Amphetamine; Animals; Clorgyline; Cocaine; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Isoenzymes; Membrane Potentials; Mesencephalon; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Nomifensine; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Selegiline; Sulpiride | 1997 |
Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septi.
Topics: Animals; Carrier Proteins; Clorgyline; Dopamine Plasma Membrane Transport Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Monoamine Oxidase Inhibitors; Neostriatum; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Selegiline; Serotonin Plasma Membrane Transport Proteins | 1997 |
Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.
Topics: Animals; Cell Survival; Cells, Cultured; Clorgyline; Dopamine; Embryo, Mammalian; gamma-Aminobutyric Acid; Indans; Mesencephalon; Methamphetamine; Microtubule-Associated Proteins; Monoamine Oxidase Inhibitors; Neurons; Rats; Rats, Sprague-Dawley; Selegiline; Tyrosine 3-Monooxygenase | 1998 |
Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities.
Topics: Amino Acid Sequence; Animals; Clorgyline; COS Cells; Humans; Isoenzymes; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Point Mutation; Recombinant Fusion Proteins; Selegiline; Sequence Homology, Amino Acid; Transfection | 1998 |
Modulation of glutamate neurotoxicity in the transformed cell culture by monoamine oxidase inhibitors, clorgyline and deprenyl.
Topics: Animals; Cell Division; Cell Line, Transformed; Cell Survival; Clorgyline; DNA, Neoplasm; Glioma; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; Monoamine Oxidase Inhibitors; Neurotoxins; Rats; Selegiline; Time Factors; Tumor Cells, Cultured | 1998 |
Pharmacological analysis of monoamine synthesis and catabolism in the scallop, Placopecten magellanicus.
Topics: alpha-Methyltyrosine; Animals; Biogenic Monoamines; Catecholamines; Catechols; Clorgyline; Fenclonine; Indoles; Methylation; Mollusca; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Selegiline; Serotonin Agents | 1998 |
In vivo comparison of the effects of inhibition of MAO-A versus MAO-B on striatal L-DOPA and dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Levodopa; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline | 1995 |
Role of monoamine oxidase type A and B on the dopamine metabolism in discrete regions of the primate brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Clorgyline; Dopamine; Enzyme Activation; Homovanillic Acid; Injections, Intramuscular; Isoenzymes; Macaca radiata; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organ Specificity; Selegiline | 1998 |
The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries.
Topics: Aged; Arteries; Clorgyline; Humans; Mandelic Acids; Methoxyhydroxyphenylglycol; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Selegiline | 1998 |
Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.
Topics: Acetamides; Animals; Anticonvulsants; Clorgyline; Glycine; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Monoamine Oxidase Inhibitors; Nociceptors; Prodrugs; Rats; Rats, Sprague-Dawley; Reference Values; Selegiline; Strychnine | 1998 |
Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells.
Topics: Animals; Astrocytes; Cell Line; Clorgyline; Food; Free Radical Scavengers; Hydrogen Peroxide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Selegiline | 1998 |
Assessment of the deamination of aminoacetone, an endogenous substrate for semicarbazide-sensitive amine oxidase.
Topics: Acetone; Allyl Compounds; Amine Oxidase (Copper-Containing); Benzylamines; Butylamines; Catalysis; Chromatography, High Pressure Liquid; Clorgyline; Deamination; Enzyme Inhibitors; Humans; Kinetics; Monoamine Oxidase Inhibitors; Phenylenediamines; Pyruvaldehyde; Selegiline; Semicarbazides; Umbilical Arteries | 1999 |
Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.
Topics: Animals; Clorgyline; Corpus Striatum; Electron Transport Complex II; Male; Malonates; Mitochondria; Monoamine Oxidase Inhibitors; Multienzyme Complexes; Neurotoxins; Nitro Compounds; Oxidoreductases; Propionates; Rats; Rats, Sprague-Dawley; Reference Values; Selegiline; Succinate Dehydrogenase | 1999 |
Inhibition of central monoamine oxidase by imidazoline2 site-selective ligands.
Topics: Animals; Benzamides; Binding Sites; Brain; Clorgyline; Imidazoles; Imidazoline Receptors; Isoenzymes; Kinetics; Ligands; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Rats; Receptors, Drug; Selegiline; Serotonin | 1999 |
Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse.
Topics: Animals; Clorgyline; Female; Immunohistochemistry; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Monoamine Oxidase; Neurons; Rats; Selegiline; Species Specificity; Tegmentum Mesencephali | 1999 |
Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cattle; Clorgyline; Dogs; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Papio; Rabbits; Rats; Rats, Sprague-Dawley; Selegiline; Species Specificity; Spectrophotometry | 1999 |
Development of N-[3-(2',4'-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropargylamine (18F-fluoroclorgyline) as a potential PET radiotracer for monoamine oxidase-A.
Topics: Animals; Brain; Clorgyline; Fluorine Radioisotopes; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Selegiline; Thiazoles; Tissue Distribution; Tomography, Emission-Computed | 1999 |
Does dopamine contribute to striatal damage caused by impaired mitochondrial function?
Topics: Animals; Apomorphine; Biological Transport; Clorgyline; Corpus Striatum; Dopamine; Malonates; Medial Forebrain Bundle; Mitochondria; Monoamine Oxidase Inhibitors; Nitro Compounds; Oxidopamine; Propionates; Rats; Selegiline; Substantia Nigra | 1999 |
Catechol concentrations in the hemolymph of the scallop, Placopecten magellanicus.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechol O-Methyltransferase Inhibitors; Catecholamines; Chromatography, High Pressure Liquid; Clorgyline; Dihydroxyphenylalanine; Dopamine; Female; Hemolymph; Male; Mollusca; Monoamine Oxidase Inhibitors; Pargyline; Selegiline; Sexual Behavior, Animal | 2000 |
Pharmacology of quinpirole-stimulated [35S]GTPgammaS binding: discrepancy with receptor binding profile.
Topics: Animals; Benzazepines; Binding, Competitive; Clorgyline; Clozapine; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Membranes; Monoamine Oxidase Inhibitors; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Selegiline; Spiperone; Sulfur Radioisotopes; Thiazoles | 2000 |
Phe(208) and Ile(199) in human monoamine oxidase A and B do not determine substrate and inhibitor specificities as in rat.
Topics: Animals; Binding Sites; Clorgyline; Humans; Isoenzymes; Isoleucine; Kinetics; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Rats; Recombinant Fusion Proteins; Recombinant Proteins; Selegiline; Substrate Specificity | 2000 |
Selective monoamine oxidase subtype inhibition and striatal extracellular dopamine in the guinea-pig.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Catecholamines; Clorgyline; Corpus Striatum; Dialysis Solutions; Dihydroxyphenylalanine; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Guinea Pigs; Homovanillic Acid; Isoenzymes; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperazines; Potassium Chloride; Rats; Selegiline; Synaptosomes; Tritium; Tyrosine 3-Monooxygenase | 2000 |
Modification of dopamine release by selective inhibitors of MAO-B.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Guinea Pigs; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperazines; Selegiline | 2000 |
Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Baculoviridae; Catalysis; Clorgyline; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; Glycine; Humans; Isoleucine; Kinetics; Molecular Sequence Data; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutagenesis, Site-Directed; Mutation; Phenethylamines; Protein Isoforms; Psychotropic Drugs; Selegiline; Sequence Homology, Amino Acid; Serotonin; Substrate Specificity; Threonine; Tyrosine | 2001 |
Selective inhibition of amine oxidases differently potentiate the hypophagic effect of benzylamine in mice.
Topics: Allyl Compounds; Amphetamine; Animals; Benzylamines; Clorgyline; Dopamine Agents; Drug Synergism; Feeding Behavior; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Propylamines; Pyridines; Selegiline; Serotonin Antagonists; Substrate Specificity; Tetraethylammonium | 2001 |
Effects of MAO inhibitors upon MPTP mice chronically treated with suprathreshold doses of L-dopa.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Clorgyline; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Levodopa; Locomotion; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Phenelzine; Phenethylamines; Selegiline; Thiazoles; Tryptamines | 2000 |
The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned rats.
Topics: Adrenergic Agents; Animals; Clorgyline; Corpus Striatum; Dopamine Agents; Dopamine Uptake Inhibitors; Levodopa; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidopamine; Parkinsonian Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra | 2000 |
Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain.
Topics: Adult; Brain; Carrier Proteins; Clorgyline; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Selegiline | 2001 |
Oxygen inhalation enhances striatal dopamine metabolism and monoamineoxidase enzyme inhibition prevents it: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Inhalation; Animals; Clorgyline; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Hyperoxia; Male; Microdialysis; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxygen; Pargyline; Rats; Rats, Sprague-Dawley; Selegiline | 2001 |
Inhibition of MAO-A activity enhances behavioural activity of rats assessed using water maze and open arena tasks.
Topics: Animals; Behavior, Animal; Clorgyline; Male; Maze Learning; Memory; Monoamine Oxidase Inhibitors; Motor Activity; Pargyline; Rats; Rats, Wistar; Selegiline; Swimming; Weight Gain | 2001 |
Role of monoamine oxidase inhibition and monoamine depletion in fenfluramine-induced neurotoxicity and serotonin release.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Clorgyline; Corpus Striatum; Dopamine; Drug Interactions; Fenclonine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Antagonists; Tryptophan | 2001 |
Limited potentiation of blood pressure response to oral tyramine by brain-selective monoamine oxidase A-B inhibitor, TV-3326 in conscious rabbits.
Topics: 2-Hydroxyphenethylamine; Administration, Oral; Adrenergic Uptake Inhibitors; Animals; Blood Pressure; Brain; Clorgyline; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Indans; Intestines; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rabbits; Selegiline; Serotonin; Tranylcypromine; Tyramine | 2002 |
Effects of monoamine oxidase inhibitors on the diethyldithiocarbamate-induced enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in C57BL/6 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Weight; Cell Death; Clorgyline; Disease Models, Animal; Ditiocarb; Dopamine; Down-Regulation; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neostriatum; Neuroprotective Agents; Parkinsonian Disorders; Presynaptic Terminals; Selegiline; Substantia Nigra | 2003 |
Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Culture Techniques; Cell Survival; Cell Transformation, Neoplastic; Clorgyline; Gamma Rays; Humans; Mice; Monoamine Oxidase Inhibitors; Radiation-Protective Agents; Selegiline; Tumor Cells, Cultured; Urinary Bladder | 2003 |
The effects of chronic administration of inhibitors of flavin and quinone amine oxidases on imidazoline I(1) receptor density in rat whole brain.
Topics: Adrenergic alpha-Agonists; Allyl Compounds; Amine Oxidase (Copper-Containing); Animals; Brain; Cell Membrane; Clonidine; Clorgyline; Drug Combinations; Guanidines; Imidazoline Receptors; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Propylamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Selegiline | 2003 |
Relationship between imidazoline(2) sites and monoamine oxidase.
Topics: Animals; Benzofurans; Brain; Cell Membrane; Clorgyline; Imidazoles; Imidazoline Receptors; Ligands; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Radioligand Assay; Rats; Receptors, Drug; Selegiline | 2003 |
Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice.
Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hindlimb Suspension; Male; Mice; Morpholines; Motor Activity; Paroxetine; Pyrazoles; Pyrimidines; Pyrroles; Reboxetine; Receptors, Corticotropin-Releasing Hormone; Selegiline; Swimming; Tranylcypromine; Triazines | 2004 |
Molecular characterization of monoamine oxidase in zebrafish (Danio rerio).
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cloning, Molecular; Clorgyline; DNA, Complementary; Liver; Molecular Sequence Data; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Open Reading Frames; Protein Binding; Protein Conformation; Selegiline; Sequence Homology, Amino Acid; Substrate Specificity; Zebrafish | 2005 |
Inhibition of methamphetamine-induced hyperlocomotion in mice by clorgyline, a monoamine oxidase-a inhibitor, through alteration of the 5-hydroxytriptamine turnover in the striatum.
Topics: Animals; Clorgyline; Corpus Striatum; Dose-Response Relationship, Drug; Drug Administration Schedule; Hyperkinesis; Male; Methamphetamine; Mice; Mice, Inbred ICR; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neural Pathways; Nucleus Accumbens; Selegiline; Serotonin | 2005 |
Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers.
Topics: Arteries; Carbon Radioisotopes; Clorgyline; Deuterium; Humans; Lung; Monoamine Oxidase; Positron-Emission Tomography; Selegiline; Smoking | 2005 |
Effects of monoamine oxidase inhibitors on methamphetamine-induced stereotypy in mice and rats.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Central Nervous System Stimulants; Clorgyline; Male; Methamphetamine; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Rats; Rats, Wistar; Selegiline; Stereotyped Behavior | 2005 |
Effects of co-administration of a selective serotonin reuptake inhibitor and monoamine oxidase inhibitors on 5-HT-related behavior in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Clorgyline; Dose-Response Relationship, Drug; Drug Synergism; Fluvoxamine; Male; Monoamine Oxidase Inhibitors; Motor Activity; Pargyline; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Syndrome | 2006 |
High-throughput screening for monoamine oxidase-A and monoamine oxidase-B inhibitors using one-step fluorescence assay.
Topics: Animals; Brain; Clorgyline; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Wistar; Reproducibility of Results; Selegiline; Sensitivity and Specificity | 2006 |
(-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.
Topics: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Clorgyline; Dose-Response Relationship, Drug; Fluoxetine; Humans; Imipramine; Iproniazid; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Selegiline; Serotonin; Stilbenes; Synaptosomes; Tritium; Wine | 2006 |
L-methamphetamine and selective MAO inhibitors decrease morphine-reinforced and non-reinforced behavior in rats; Insights towards selegiline's mechanism of action.
Topics: Animals; Behavior, Animal; Body Weight; Central Nervous System Stimulants; Clorgyline; Conditioning, Operant; Extinction, Psychological; Indans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Morphine; Morphine Dependence; Rats; Rats, Wistar; Reinforcement, Psychology; Selegiline; Self Administration; Substance Withdrawal Syndrome | 2006 |
Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus.
Topics: Animals; Brain; Clorgyline; Coumarins; Dictamnus; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Mice; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2006 |
Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs.
Topics: Acid-Base Equilibrium; Acids; Alzheimer Disease; Amantadine; Animals; Brain; Brain Chemistry; Brain Diseases; Cell Line, Tumor; Clorgyline; Endocytosis; Exocytosis; Hydrogen-Ion Concentration; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organelles; Pargyline; Parkinson Disease; Protons; Selegiline; Signal Transduction; Transport Vesicles | 2009 |
Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Clorgyline; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Factor Analysis, Statistical; Female; Infusion Pumps, Implantable; Injections, Intraperitoneal; Monoamine Oxidase Inhibitors; Motor Activity; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Selegiline; Sensory Thresholds; Time Factors; Vasoconstrictor Agents | 2007 |
In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human.
Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbon Radioisotopes; Carboxylic Acids; Chromatography, High Pressure Liquid; Clorgyline; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Female; Glucuronides; Hepatocytes; Humans; Hydroxylation; In Vitro Techniques; Lactams; Liver; Macaca fascicularis; Male; Mice; Microsomes, Liver; Middle Aged; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; NADP; Oxidation-Reduction; Quinidine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Selegiline; Species Specificity; Tandem Mass Spectrometry | 2007 |
Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area.
Topics: Animals; Clorgyline; Dopamine; Electrophysiology; Evoked Potentials; Male; Monoamine Oxidase Inhibitors; Neurons; Norepinephrine; Phenelzine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Selegiline; Serotonin; Serotonin Antagonists; Ventral Tegmental Area | 2009 |
[A comparison of the pharmacology of (-)-deprenyl to N-methylpropargylamine-1-aminoindane (J-508) and rasagiline, the desmethyl-analogue of J-508].
Topics: Adrenergic Uptake Inhibitors; Animals; Brain Stem; Catecholamines; Clorgyline; Indans; Learning; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Pargyline; Rats; Selegiline; Tetrabenazine | 2008 |
Short-term erythrosine B-induced inhibition of the brain regional serotonergic activity suppresses motor activity (exploratory behavior) of young adult mammals.
Topics: Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; Erythrosine; Exploratory Behavior; Food Coloring Agents; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Rats; Receptors, Serotonin; Selegiline; Serotonin; Time Factors; Tissue Distribution | 2009 |
Beta-phenylethylamine and benzylamine as substrates for human monoamine oxidase A: A source of some anomalies?
Topics: Benzylamines; Clorgyline; Deamination; Enzyme Inhibitors; Female; Humans; Kinetics; Monoamine Oxidase; Phenethylamines; Placenta; Pregnancy; Selegiline; Substrate Specificity; Tissue Distribution | 1980 |
Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Chromatography, High Pressure Liquid; Clorgyline; Enzyme Assays; Harmine; Humans; Indazoles; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Nicotiana; Oxidation-Reduction; Pyridinium Compounds; Recombinant Proteins; Selegiline; Smoke; Vitamin K 3 | 2012 |
In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase.
Topics: Anilides; Clorgyline; Drug Interactions; Drug Partial Agonism; GABA-A Receptor Agonists; Humans; In Vitro Techniques; Indoles; Kinetics; Metabolic Clearance Rate; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Selegiline; Sumatriptan | 2012 |
Monoamine oxidase assays.
Topics: Aldehyde Dehydrogenase; Animals; Clorgyline; Enzyme Assays; Epinephrine; Fluorometry; Humans; Hydrogen Peroxide; Ion Exchange Resins; Isoenzymes; Monoamine Oxidase; Norepinephrine; Oxidation-Reduction; Oxygen Consumption; Radioisotopes; Rats; Selegiline; Spectrophotometry | 2001 |
Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Clorgyline; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Hypotension; Injections, Intravenous; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pressoreceptors; Rats; Rats, Sprague-Dawley; Selegiline; Vasoconstrictor Agents; Vasodilator Agents | 2012 |
Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice.
Topics: Animals; Clorgyline; Disease Models, Animal; Female; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuralgia; Postoperative Complications; Rotarod Performance Test; Selegiline | 2012 |
Inhibition of monoamine oxidase isoforms modulates nicotine withdrawal syndrome in the rat.
Topics: Animals; Brain; Clorgyline; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotine; Rats; Rats, Sprague-Dawley; Selegiline; Smoking Cessation; Substance Withdrawal Syndrome | 2013 |
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
Topics: Bupropion; Clorgyline; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2B6 Inhibitors; Drug Interactions; Glutathione; Humans; Hydroxylation; Inhibitory Concentration 50; Kinesics; Microsomes, Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Selegiline | 2015 |
Design, Synthesis, and Evaluation of 2-Amino-6-nitrobenzothiazole-Derived Hydrazones as MAO Inhibitors: Role of the Methylene Spacer Group.
Topics: Animals; Antidepressive Agents; Benzothiazoles; Brain; Catalytic Domain; Clorgyline; Drug Design; Hydrazones; Hydrogen Bonding; Kinetics; Ligands; Molecular Docking Simulation; Monoamine Oxidase Inhibitors; Phenytoin; Rats; Selegiline; Structure-Activity Relationship | 2016 |
Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Survival; Clorgyline; Embryonal Carcinoma Stem Cells; Fluoxetine; Gene Expression; Membrane Potential, Mitochondrial; Mice; Monoamine Oxidase; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Selegiline; Serotonin Plasma Membrane Transport Proteins | 2016 |
Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.
Topics: Animals; Cerebral Cortex; Clorgyline; Furans; Male; Microdialysis; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Sprague-Dawley; Selegiline; Serotonin | 2017 |
Brain region specific methylation and Sirt1 binding changes in MAOA promoter is associated with sexual dimorphism in early life stress induced aggressive behavior.
Topics: Aggression; Agonistic Behavior; Animals; Base Sequence; Clorgyline; DNA Methylation; Fear; Female; Hypothalamus; Male; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Tissue Proteins; Odorants; Prefrontal Cortex; Promoter Regions, Genetic; Selegiline; Sex Characteristics; Sirtuin 1; Stress, Psychological | 2019 |
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
Topics: Animals; Clorgyline; Corpus Striatum; Dopamine; Female; gamma-Aminobutyric Acid; Male; Mice, Inbred C57BL; Molecular Imaging; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Patch-Clamp Techniques; Rats, Sprague-Dawley; Selegiline | 2021 |