Page last updated: 2024-08-23

selegiline and 1-methyl-4-phenylpyridinium

selegiline has been researched along with 1-methyl-4-phenylpyridinium in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (24.56)	18.7374
1990's	27 (47.37)	18.2507
2000's	12 (21.05)	29.6817
2010's	3 (5.26)	24.3611
2020's	1 (1.75)	2.80

Authors

Authors	Studies
Marsden, CD	1
Fuller, RW; Hemrick-Luecke, SK; Krushinski, JH; Robertson, DW	1
Delanney, LE; Di Monte, DA; Irwin, I; Langston, JW; Wu, EY	1
Bellomo, G; Di Monte, D; Smith, MT; Wu, EY	1
Fuller, RW; Hemrick-Luecke, SK	2
Bradbury, AJ; Costall, B; Jenner, PG; Kelly, ME; Marsden, CD; Naylor, RJ	1
Arai, Y; Kinemuchi, H; Kisara, K; Matsumura, T; Sakuma, I; Satoh, N; Tadano, T	1
Batra, JK; Bhatnagar, R; Krishna, G; Sidhu, GS; Singh, Y	1
Kass, GE; Nicotera, P; Orrenius, S; Wright, JM	1
Gibb, C; Glover, V; Sandler, M	1
Heikkila, RE; Kindt, MV; Nicklas, WJ; Youngster, SK	1
Duvoisin, RC; Heikkila, RE; Nicklas, WJ	1
Nagatsu, T; Naoi, M; Takahashi, T	1
Mihatsch, W; Przuntek, H; Russ, H	1
Fuller, RW; Hemrick-Luecke, SK; Perry, KW	1
Krishna, G; Kutty, RK; Singh, Y; Sokoloski, E; Swanson, E	1
Lewin, R	1
Cohen, G; Mytilineou, C	1
Corsini, GU; Fascetti, F; Fornai, F; Maggio, R; Vaglini, F	1
Chiueh, CC; Mohanakumar, KP; Murphy, DL; Wu, RM	1
Chen, TS; Koutsilieri, E; O'Callaghan, JF; Rausch, WD; Riederer, P	1
Altagracia, M; Bravo-Velazquez, S; Kravzov, J; Ríos, C	1
Chiueh, CC; Murphy, DL; Pert, A; Wu, RM	1
Singer, TP; Tipton, KF	1
Griffiths, H; Lai, M; Lunec, J; Pall, H; Williams, A	1
Feuerstein, TJ; Hedler, L; Lücking, CH; Lupp, A	1
Ayala, A; Cano, J; Machado, A; Steffen, V; Vizuete, ML	1
Ali, SF; Freyaldenhoven, TE; Hart, RW	1
Chiueh, CC; Murphy, DL; Wu, RM	2
Chen, TS; Koutsilieri, E; Rausch, WD; Riederer, P	1
Cavalletti, M; Corsini, GU; Fascetti, F; Fornai, F; Tedeschi, D; Vaglini, F	1
Boismenu, D; Mamer, O; Montgomery, J; Ste-Marie, L; Vachon, L	1
Olanow, CW	1
Cavalletti, M; Corsini, GU; Maggio, R; Pardini, C; Vaglini, F	1
Appel, SH; Jankovic, J; Kong, R; Le, W; Xie, W	1
Ebert, MH; Lynn, JC; Schmidt, DE; Whetsell, WO	1
Bémeur, C; Lambert, J; Montgomery, J; Ste-Marie, L; Vachon, L	1
Castagnoli, K; Castagnoli, N; Palmer, S	1
Akaike, A; Kaneko, S; Katsuki, H; Kume, T	1
Chen, RC; Chiueh, CC; Wu, RM	1
Wu, WR; Zhu, XZ; Zhu, ZT	1
Hengerer, B; Spooren, WP; Waldmeier, PC	1
Awaya, T; Chiba, K; Hayase, N; Kimura, K; Matsubara, K; Ogawa, S; Senda, T; Shimizu, K; Uezono, T	1
Matsubara, K; Ohtaki, K; Shimizu, K; Shiono, H	1
Mohanakumar, KP; Muralikrishnan, D; Samantaray, S	1
Carlson, EC; Ebadi, M; Sharma, SK	1
Ashmeade, TE; Austin, AA; Billinton, A; Hows, ME; Organ, AJ; Perren, MJ; Shah, AJ; Virley, DJ	1
Andoh, T; Chiueh, CC; Chock, PB; Murphy, DL	1
Chagkutip, J; Ebadi, M; Govitrapong, P; Klongpanichpak, S	1
Chetsawang, B; Ebadi, M; Govitrapong, P; Kooncumchoo, P	1
Kaslin, J; Khrustalyov, D; Panula, P; Reenilä, I; Sallinen, V; Sundvik, M; Torkko, V	1
Ito, T; Nakayama, H; Suzuki, K; Uchida, K	1
Herraiz, T	1
Cao, X; Jing, P; Lv, F; Xiao, H; Xu, W; Zhang, L	1
Chen, J; Chen, Y; Yu, H; Zhao, J; Zheng, Y; Zhu, J	1

Reviews

4 review(s) available for selegiline and 1-methyl-4-phenylpyridinium

Article	Year
Parkinson's disease. Lancet (London, England), 1990, Apr-21, Volume: 335, Issue:8695 Topics: 1-Methyl-4-phenylpyridinium; Adrenal Glands; Adult; Antiparkinson Agents; Brain Chemistry; Child; Child, Preschool; Cytoplasmic Granules; Dyskinesia, Drug-Induced; Environmental Pollutants; Fetus; Humans; Levodopa; Middle Aged; Palliative Care; Parkinson Disease; Prevalence; Research; Selegiline; Substantia Nigra; Time Factors	1990
Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline). Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738 Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Animals; Antioxidants; Corpus Striatum; Free Radicals; Humans; Hydroxyl Radical; Lipid Peroxidation; Monoamine Oxidase; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra	1994
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. Journal of neurochemistry, 1993, Volume: 61, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aging; Animals; Biological Transport; Humans; Mitochondria; Nervous System; Oxidation-Reduction; Parkinson Disease; Selegiline; Species Specificity	1993
Deprenyl in the treatment of Parkinson's disease: clinical effects and speculations on mechanism of action. Journal of neural transmission. Supplementum, 1996, Volume: 48 Topics: 1-Methyl-4-phenylpyridinium; Antioxidants; Apoptosis; Clinical Trials as Topic; Dopamine; Double-Blind Method; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Randomized Controlled Trials as Topic; Selegiline	1996

Trials

1 trial(s) available for selegiline and 1-methyl-4-phenylpyridinium

Article	Year
Clinical trial for Parkinson's disease? Science (New York, N.Y.), 1985, Nov-01, Volume: 230, Issue:4725 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Levodopa; Models, Neurological; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Pyridines; Pyridinium Compounds; Selegiline	1985

Article

Year

Clinical trial for Parkinson's disease?

Science (New York, N.Y.), 1985, Nov-01, Volume: 230, Issue:4725

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Levodopa; Models, Neurological; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Pyridines; Pyridinium Compounds; Selegiline

1985

Other Studies

52 other study(ies) available for selegiline and 1-methyl-4-phenylpyridinium

Article	Year
Persistent depletion of striatal dopamine and cortical norepinephrine in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-3-pyridinol (MPTP-3-OL), an analog of MPTP. Life sciences, 1992, Volume: 50, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain Chemistry; Catecholamines; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Norepinephrine; Selegiline	1992
Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Biotransformation; Cells, Cultured; Clorgyline; Cytochrome P-450 Enzyme System; Mice; Monoamine Oxidase; Oxygenases; Selegiline	1991
Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes. Archives of biochemistry and biophysics, 1990, Nov-01, Volume: 282, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Survival; Fluorescent Dyes; Fructose; In Vitro Techniques; Intracellular Membranes; Liver; Male; Membrane Potentials; Mitochondria, Liver; MPTP Poisoning; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Selegiline	1990
Tissue concentrations of MPTP and MPP+ after administration of lethal and sublethal doses of MPTP to mice. Toxicology letters, 1990, Volume: 54, Issue:2-3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Oral; Animals; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Male; Mice; Monoamine Oxidase; MPTP Poisoning; Selegiline; Tissue Distribution	1990
The neurotoxic actions of 1-methyl-4-phenylpyridine (MPP+) are not prevented by deprenyl treatment. Neuroscience letters, 1985, Jul-31, Volume: 58, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Mice; Motor Activity; Neurotransmitter Agents; Norepinephrine; Parkinson Disease, Secondary; Phenethylamines; Pyridinium Compounds; Selegiline; Serotonin	1985
Behavioral and biochemical changes following acute administration of MPTP and MPP+. Life sciences, 1987, Mar-30, Volume: 40, Issue:13 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Desipramine; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Motor Activity; Nomifensine; Pyridines; Pyridinium Compounds; Selegiline; Serotonin	1987
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits proton motive force in energized liver mitochondria. Archives of biochemistry and biophysics, 1989, May-15, Volume: 271, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Action Potentials; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Energy Metabolism; Hydrogen-Ion Concentration; Male; Membrane Potentials; Mitochondria, Liver; Neurotoxins; Protons; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline	1989
The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium. Archives of biochemistry and biophysics, 1988, Feb-01, Volume: 260, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Membrane Permeability; Cell Survival; Cytosol; Liver; Male; Mitochondria; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline	1988
Monoamine oxidase B(MAO-B) is the major catalyst for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation in human brain and other tissues. Neuroscience letters, 1986, Feb-28, Volume: 64, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Humans; In Vitro Techniques; Isoenzymes; Mice; Monoamine Oxidase; Oxidation-Reduction; Phenethylamines; Pyridines; Pyridinium Compounds; Rats; Selegiline; Species Specificity	1986
Depletion of norepinephrine in mouse heart by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mimicked by 1-methyl-4-phenylpyridinium (MPP+) and not blocked by deprenyl. Life sciences, 1986, Nov-03, Volume: 39, Issue:18 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Heart; Mice; Myocardium; Norepinephrine; Phenethylamines; Pyridines; Pyridinium Compounds; Selegiline	1986
MPTP, MPP+ and mitochondrial function. Life sciences, 1987, Feb-23, Volume: 40, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Corpus Striatum; Glycolysis; In Vitro Techniques; Kinetics; Liver; Mice; Mitochondria; Oxygen Consumption; Pyridines; Pyridinium Compounds; Rats; Selegiline; Structure-Activity Relationship	1987
Studies on the mechanism of the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Advances in neurology, 1987, Volume: 45 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred Strains; Pyridines; Pyridinium Compounds; Receptors, Dopamine; Selegiline	1987
Metabolism of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a rat pheochromocytoma cell line, PC12h. Life sciences, 1987, Dec-14, Volume: 41, Issue:24 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Clorgyline; Culture Media; Monoamine Oxidase; Neurons; Osmolar Concentration; Pheochromocytoma; Pyridines; Pyridinium Compounds; Rats; Selegiline; Tumor Cells, Cultured	1987
Intracerebroventricular administration of 1-methyl-4-phenylpyridinium ion in mice: effects of simultaneously administered nomifensine, deprenyl, and 1-t-butyl-4,4-diphenylpiperidine. Journal of neural transmission, 1988, Volume: 71, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Catecholamines; Caudate Nucleus; Dose-Response Relationship, Drug; Drug Interactions; Female; Injections, Intraventricular; Male; Monoamine Oxidase Inhibitors; Movement Disorders; Nomifensine; Phenethylamines; Piperidines; Pyridinium Compounds; Selegiline; Serotonin	1988
Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Bridged Bicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Isoenzymes; Lethal Dose 50; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Pyridines; Pyridinium Compounds; Salivation; Selegiline	1988
MPTP and MPTP analogs induced cell death in cultured rat hepatocytes involving the formation of pyridinium metabolites. Toxicology and applied pharmacology, 1988, Volume: 96, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Survival; Glutathione; Liver; Male; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline	1988
Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion. Journal of neurochemistry, 1985, Volume: 45, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; Neurons; Phenethylamines; Pyridines; Pyridinium Compounds; Rats; Selegiline; Synaptosomes	1985
(+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice. Brain research, 1994, Dec-30, Volume: 668, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Ditiocarb; Dizocilpine Maleate; Dopamine; Drug Synergism; Haplorhini; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Piperazines; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase	1994
Selegiline enhances survival and neurite outgrowth of MPP(+)-treated dopaminergic neurons. European journal of pharmacology, 1994, Nov-15, Volume: 269, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Mesencephalon; Mice; Mice, Inbred C57BL; Neostriatum; Neurites; Neurons; Selegiline	1994
Enhancement of striatal lipid peroxidation induced by 1-methyl-4-phenylpyridinium in mouse brain is blocked by MAO-B inhibitors. Proceedings of the Western Pharmacology Society, 1994, Volume: 37 Topics: 1-Methyl-4-phenylpyridinium; Animals; Clorgyline; Lipid Peroxidation; Male; Mice; Monoamine Oxidase Inhibitors; Neostriatum; Pargyline; Selegiline	1994
Apparent antioxidant effect of l-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo. European journal of pharmacology, 1993, Oct-26, Volume: 243, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Dopamine; Hydroxyl Radical; Male; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra	1993
An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines. Biochemical pharmacology, 1993, Feb-24, Volume: 45, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxides; MPTP Poisoning; Neurons; Pargyline; Rats; Reactive Oxygen Species; Selegiline; Superoxide Dismutase; Tumor Cells, Cultured	1993
Different effects of 1-methyl-4-phenyl-pyridinium (MPP+) on monoamine oxidase of dopaminergic terminals in caudate nucleus slices from pigmented and from albino rabbits. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 347, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Caudate Nucleus; Clorgyline; Dopamine; Female; In Vitro Techniques; Kinetics; Male; Melanins; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Endings; Pigmentation; Rabbits; Selegiline; Serotonin; Tritium	1993
Protective effect of deprenyl against 1-methyl-4-phenylpyridinium neurotoxicity in rat striatum. Neuroscience letters, 1993, Apr-02, Volume: 152, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Catalase; Corpus Striatum; Dopamine; Male; Monoamine Oxidase; NAD(P)H Dehydrogenase (Quinone); Nerve Tissue Proteins; Oxidation-Reduction; Rats; Rats, Wistar; Selegiline; Superoxide Dismutase	1993
MPTP- and MPP(+)-induced effects on body temperature exhibit age- and strain-dependence in mice. Brain research, 1995, Aug-07, Volume: 688, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Aging; Analysis of Variance; Animals; Body Temperature Regulation; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Selegiline; Species Specificity	1995
Suppression of hydroxyl radical formation and protection of nigral neurons by l-deprenyl (selegiline). Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786 Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Dopamine; Hydroxyl Radical; Male; Neurons; Rats; Rats, Sprague-Dawley; Selegiline; Time Factors	1996
Neuronal protective and rescue effects of deprenyl against MPP+ dopaminergic toxicity. Journal of neural transmission. General section, 1995, Volume: 100, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Dopamine Agents; Drug Interactions; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra	1995
Selegiline is neuroprotective in primary brain cultures treated with 1-methyl-4-phenylpyridinium. European journal of pharmacology, 1996, Jun-13, Volume: 306, Issue:1-3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Dopamine; Dopamine Agents; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Selegiline; Tyrosine 3-Monooxygenase	1996
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 1996, Volume: 5, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Ditiocarb; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nicotine; Piperazines; Selegiline; Serotonin	1996
In vivo hydroxylation of the neurotoxin, 1-methyl-4-phenylpyridinium, and the effect of monoamine oxidase inhibitors: electrospray-MS analysis of intra-striatal microdialysates. Journal of mass spectrometry : JMS, 1996, Volume: 31, Issue:10 Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Butylamines; Dopamine Agents; Hydroxyl Radical; Hydroxylation; Male; Mass Spectrometry; Microdialysis; Monoamine Oxidase Inhibitors; Neostriatum; Rats; Rats, Sprague-Dawley; Selegiline; Spectrometry, Mass, Fast Atom Bombardment	1996
L-deprenyl fails to protect mesencephalic dopamine neurons and PC12 cells from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion. Brain research, 1996, Nov-25, Volume: 741, Issue:1-2 Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cells, Cultured; Choline; Dopamine; Dopamine Agents; Dopamine Antagonists; Immunohistochemistry; Mesencephalon; Mice; Monoamine Oxidase Inhibitors; Neurons; PC12 Cells; Rats; Selegiline; Tyrosine 3-Monooxygenase	1996
(-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition. Neuroscience letters, 1997, Mar-21, Volume: 224, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cells, Cultured; Hybrid Cells; Monoamine Oxidase; Neurons; Selegiline	1997
Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures. Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:8-9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Dogs; Dopamine; Dopamine Agents; Homovanillic Acid; MPTP Poisoning; Neurons; Neuroprotective Agents; Organ Culture Techniques; Selegiline; Substantia Nigra	1997
Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate. Free radical biology & medicine, 1999, Volume: 27, Issue:9-10 Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Antioxidants; Butylamines; Corpus Striatum; Dopamine; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Injections, Intraperitoneal; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neurotoxins; Parabens; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline	1999
Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity. Neurobiology (Budapest, Hungary), 1999, Volume: 7, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cattle; Corpus Striatum; Dopamine; Indazoles; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Neuroprotective Agents; Neurotoxins; Selegiline	1999
[Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1 Topics: 1-Methyl-4-phenylpyridinium; Animals; Buthionine Sulfoximine; Cell Death; Culture Techniques; Dopamine; Excitatory Amino Acid Agonists; Immunohistochemistry; Monoamine Oxidase; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase	1999
Effect of MAO-B inhibitors on MPP+ toxicity in Vivo. Annals of the New York Academy of Sciences, 2000, Volume: 899 Topics: 1-Methyl-4-phenylpyridinium; Animals; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Selegiline; Substantia Nigra	2000
Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens. Life sciences, 2000, Jun-08, Volume: 67, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Selegiline	2000
CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Brain; Cell Culture Techniques; Cell Death; Disease Models, Animal; Dopamine; Female; Liver; Mesencephalon; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Oxepins; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Selegiline; Substantia Nigra; Tritium; Tyrosine 3-Monooxygenase	2000
L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats. Neuroscience letters, 2001, Apr-20, Volume: 302, Issue:2-3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Carbolines; Cell Hypoxia; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Herbicides; Lactic Acid; Male; Microdialysis; Mitochondria; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxins; Pargyline; Parkinson Disease; Rats; Rats, Wistar; Selegiline	2001
Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neuroscience research, 2003, Volume: 46, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Animals, Newborn; Azepines; Cabergoline; Caspases; Cell Count; Cycloheximide; Dizocilpine Maleate; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Herbicides; Immunohistochemistry; Mesencephalon; NADPH Dehydrogenase; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Organ Culture Techniques; Paraquat; Piperazines; Protein Synthesis Inhibitors; Quinoxalines; Rats; Rats, Wistar; Selegiline; Tyrosine 3-Monooxygenase	2003
D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse (New York, N.Y.), 2003, Volume: 50, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Isomerism; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Neostriatum; Neural Pathways; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Selegiline; Substantia Nigra	2003
Neuroprotective actions of Selegiline in inhibiting 1-methyl, 4-phenyl, pyridinium ion (MPP+)-induced apoptosis in SK-N-SH neurons. Journal of neurocytology, 2003, Volume: 32, Issue:4 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Cell Line, Tumor; Cell Membrane; Cytoprotection; Dose-Response Relationship, Drug; Free Radicals; Genes, Immediate-Early; Humans; Intracellular Membranes; Microscopy, Electron; Mitochondria; Nerve Degeneration; Neurites; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylserines; Selegiline	2003
High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates. Journal of neuroscience methods, 2004, Aug-30, Volume: 137, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Mice; Reproducibility of Results; Selegiline; Sensitivity and Specificity; Time Factors; Tissue Distribution	2004
Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Molecular pharmacology, 2005, Volume: 68, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Humans; Lipid Peroxidation; Mice; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA, Messenger; Selegiline; Thioredoxins	2005
Mechanism of 1-methyl-4-phenylpyridinium-induced dopamine release from PC12 cells. Neurochemical research, 2005, Volume: 30, Issue:5 Topics: 1-Methyl-4-phenylpyridinium; Adrenal Medulla; Animals; Calcium; Dopamine; Dopamine Uptake Inhibitors; Exocytosis; Mazindol; Monoamine Oxidase Inhibitors; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species; Selegiline; Synaptophysin; Tyrosine	2005
1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline. Neurochemistry international, 2008, Volume: 53, Issue:6-8 Topics: 1-Methyl-4-phenylpyridinium; Apoptosis Regulatory Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Herbicides; Humans; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phosphorylation; Proteins; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; Selegiline; Serine; Signal Transduction	2008
MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. Journal of neurochemistry, 2009, Volume: 108, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Behavior, Animal; Biogenic Monoamines; Catecholamines; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Image Processing, Computer-Assisted; Immunohistochemistry; Larva; Locomotion; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Norepinephrine; Selegiline; Swimming; Zebrafish	2009
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuroblastic apoptosis in the subventricular zone is caused by 1-methy-4-phenylpiridinium (MPP(+)) converted from MPTP through MAO-B. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:7-8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cerebral Ventricles; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Doublecortin Protein; Ependyma; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microtubule-Associated Proteins; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neural Stem Cells; Neuropeptides; Selegiline	2012
Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents. Journal of enzyme inhibition and medicinal chemistry, 2012, Volume: 27, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Chromatography, High Pressure Liquid; Clorgyline; Enzyme Assays; Harmine; Humans; Indazoles; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Nicotiana; Oxidation-Reduction; Pyridinium Compounds; Recombinant Proteins; Selegiline; Smoke; Vitamin K 3	2012
Deprenyl prevents MPP(+)-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk. Toxicology, 2011, Dec-18, Volume: 290, Issue:2-3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Antiparkinson Agents; Extracellular Signal-Regulated MAP Kinases; NAD(P)H Dehydrogenase (Quinone); Neuroprotective Agents; NF-E2-Related Factor 2; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Selegiline; Signal Transduction; Up-Regulation	2011
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model. Molecules (Basel, Switzerland), 2022, Aug-06, Volume: 27, Issue:15 Topics: 1-Methyl-4-phenylpyridinium; Animals; Biflavonoids; Catechin; Oxidative Stress; Parkinson Disease; Proanthocyanidins; Rats; Selegiline; Zebrafish	2022