selegiline has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (37.96) | 18.7374 |
| 1990's | 54 (39.42) | 18.2507 |
| 2000's | 22 (16.06) | 29.6817 |
| 2010's | 8 (5.84) | 24.3611 |
| 2020's | 1 (0.73) | 2.80 |
| Authors | Studies |
|---|---|
| Duchemin, AM; Gudehithlu, KP; Hadjiconstantinou, M; Neff, NH | 1 |
| Chiueh, CC; Huang, SJ; Murphy, DL | 1 |
| Chia, LG; Lee, EH; Liu, SP | 1 |
| Szelenyi, I; Wessel, K | 1 |
| Chan, P; DeLanney, LE; Di Monte, D; Irwin, I; Langston, JW | 1 |
| Greenwood, CE; Tatton, WG | 1 |
| Chan, WW; Rausch, WD; Riederer, P; Schallauer, E; Weiser, M | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Krushinski, JH; Robertson, DW | 1 |
| Buckman, TD | 1 |
| Chacón, JN; Truscott, TG | 1 |
| Itzhak, Y; Mash, D; Stein, I; Zhang, SH | 1 |
| Duchemin, AM; Gudehithlu, KP; Hadjiconstantinou, M; Neff, NH; Tejwani, GA | 1 |
| Kofman, OS | 1 |
| Delanney, LE; Di Monte, DA; Irwin, I; Langston, JW; Wu, EY | 1 |
| Dhawan, BN; Gupta, GP; Gupta, MB; Gurtu, S; Nath, C; Srimal, RC | 1 |
| Pai, KS; Ravindranath, V | 1 |
| Bhatti, AR; Devlin, AJ; Ramsden, DB; Williams, AC | 1 |
| Sheng, J | 1 |
| Da Prada, M; Haefely, WE; Keller, HH; Kettler, R | 1 |
| Bellomo, G; Di Monte, D; Smith, MT; Wu, EY | 1 |
| Fuller, RW; Hemrick-Luecke, SK | 3 |
| Heikkila, RE; Sieber, BA; Terleckyj, I | 1 |
| Arai, Y; Kinemuchi, H; Kisara, K; Matsumura, T; Sakuma, I; Satoh, N; Tadano, T | 1 |
| Eldrup, E; Fog, R; Pakkenberg, B; Pakkenberg, H | 1 |
| Lewin, R | 2 |
| Langston, JW; Tetrud, JW | 2 |
| Hashim, A; Lajtha, A; Sershen, H; Wiener, HL | 1 |
| Bizière, K; Guillaumin, JM; Kan, JP; Renoux, G; Renoux, M; Steinberg, R | 1 |
| Batra, JK; Bhatnagar, R; Krishna, G; Sidhu, GS; Singh, Y | 1 |
| Bradbury, AJ; Costall, B; Jenner, P; Kelly, ME; Marsden, GD; Naylor, RJ | 1 |
| Akos, K | 1 |
| Bonetti, EP; Da Prada, M; Imhof, R; Keller, HH; Kettler, R | 1 |
| Kass, GE; Nicotera, P; Orrenius, S; Wright, JM | 1 |
| Gibb, C; Glover, V; Sandler, M | 2 |
| Heikkila, RE; Kindt, MV | 1 |
| Bernardi, F; Bonuccelli, U; Corsini, GU; Del Zompo, M; Piccardi, MP | 1 |
| Jenner, P; Marsden, CD | 1 |
| Stern, G | 1 |
| Sandler, M | 1 |
| Bocchetta, A; Corsini, GU; Del Zompo, M; Piccardi, MP; Pintus, S | 2 |
| Knoll, J | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Robertson, DW | 1 |
| Heikkila, RE; Kindt, MV; Nicklas, WJ; Youngster, SK | 1 |
| McCrodden, JM; Tipton, KF; Youdim, MB | 1 |
| Finberg, JP; Youdim, MB | 1 |
| Duvoisin, RC; Heikkila, RE; Nicklas, WJ | 1 |
| Langston, JW | 1 |
| Nagatsu, T; Naoi, M; Takahashi, T | 1 |
| Fuller, RW; Heikkila, RE; Hemrick-Luecke, SK; Kindt, MV | 1 |
| Gibb, C; Glover, V; Sandler, M; Willoughby, J | 1 |
| Yahr, MD | 1 |
| Duvoisin, RC; Heikkila, RE; Kindt, MV; Sonsalla, PK; Youngster, SK | 1 |
| Giovanni, A; Heikkila, RE; Kindt, MV; McKeown, KA; Singer, TP; Sonsalla, PK; Youngster, SK | 1 |
| Sheng, JG; Xu, DL; Yu, HZ | 1 |
| Grimm, LJ; Kellar, KJ; Kettler, KG; Perry, DC | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Perry, KW | 1 |
| Larsson, BS; Lindquist, NG; Lydén-Sokolowski, A | 1 |
| Krishna, G; Kutty, RK; Singh, Y; Sokoloski, E; Swanson, E | 1 |
| Golbe, LI; Sonsalla, PK | 1 |
| Duvoisin, RC; Heikkila, RE; Hess, A | 1 |
| Cohen, G; Mytilineou, C | 2 |
| Corsini, GU; Del Zompo, M; Pintus, S; Zuddas, A | 1 |
| Cabbat, FS; Duvoisin, RC; Heikkila, RE; Manzino, L | 1 |
| Duvoisin, RC; Finberg, JP; Heikkila, RE; Youdim, MB | 1 |
| Castagnoli, N; Chiba, K; Trevor, A | 1 |
| Williams, A | 1 |
| Cohen, B; Cohen, G; Leist, A; Mytilineou, C; Pasik, P; Yahr, MD | 1 |
| Gupta, M; Wiener, HL | 1 |
| Aumont, N; Poirier, J; Quirion, R; Thiffault, C | 1 |
| Delanney, LE; Finnegan, KT; Irwin, I; Langston, JW | 1 |
| Ichikawa, Y; Wu, RF | 1 |
| Holdup, D; Liptrot, J; Phillipson, O | 1 |
| Burger, R; Dirr, A; Freyberger, A; Götz, ME; Gsell, W; Janetzky, B; Rausch, WD; Reichmann, H; Riederer, P | 1 |
| Chia, LG; Kuo, JS; Lee, EH; Yang, YL | 1 |
| Chan, P; Di Monte, DA; Langston, JW | 1 |
| Gaál, J; Kardos, V; Kollár, E; Pátfalusi, M; Patthy, M; Singer, J; Solti, M; Sziráki, I | 1 |
| Tipton, KF | 1 |
| Agata, M; Matsumoto, J; Sasada, N; Takahashi, T; Toyofuku, H | 1 |
| Akiguchi, I; Kimura, J; Nakamura, S | 1 |
| Andrews, AM; Murphy, DL | 1 |
| Tatton, WG | 1 |
| Rinne, JO | 1 |
| Singer, TP; Tipton, KF | 1 |
| Griffiths, H; Lai, M; Lunec, J; Pall, H; Williams, A | 1 |
| Hattori, T; Sugimoto, T; Takada, M | 1 |
| Boulton, AA; Davis, BA; Fang, J; Lai, CT; Li, XM; Paterson, IA; Yu, PH; Zhang, X; Zuo, DM | 1 |
| Chen, TS; Koutsilieri, E; Rausch, WD; Riederer, P | 1 |
| Cavalletti, M; Corsini, GU; Fascetti, F; Fornai, F; Tedeschi, D; Vaglini, F | 1 |
| Andersen, JK; Jurma, OP; Wei, Q; Yeung, M | 1 |
| Lamarre-Théroux, L; Poirier, J; Quirion, R; Thiffault, C | 1 |
| Ali, SF; Freyaldenhoven, TE; Schmued, LC | 1 |
| Archer, T; Eriksson, P; Fredriksson, A | 1 |
| Ebert, MH; Lynn, JC; Schmidt, DE; Whetsell, WO | 1 |
| Rothblat, DS; Schneider, JS | 1 |
| Chao, CC; Chen, KY; Lee, EH; Ma, YL; Tang, YP | 1 |
| Wu, WR; Zhu, XZ | 1 |
| Guan, HJ; Ji, XQ; Wang, RG; Wu, WR; Zhu, XZ | 1 |
| Castagnoli, K; Castagnoli, N; Igarashi, K; Inoue, H; Mabic, S; Van Der Schyf, C | 1 |
| Castagnoli, K; Castagnoli, N; Palmer, S | 1 |
| Billett, EE; De Girolamo, LA; Hargreaves, AJ | 1 |
| Saporito, MS; Scott, RW; Thomas, BA | 1 |
| Wu, WR; Zhu, XZ; Zhu, ZT | 1 |
| Ebadi, M; Muralikrishnan, D | 1 |
| Archer, T; Fredriksson, A; Palomo, T | 1 |
| Morón, J; Pastó, M; Pérez, V; Unzeta, M | 1 |
| Castagnoli, K; Castagnoli, N; Steyn, S; Steyn, SJ | 1 |
| Breithaupt, W; Gerlach, M; Götz, ME; Kupsch, A; Oertel, WH; Riederer, P; Sautter, J; Schwarz, J; Youdim, MB | 1 |
| Chen, H; Chen, S; Guo, M; Liu, Z | 1 |
| Barja, G; Fabre, E; Gredilla, R; Leret, ML; San Millán, JA | 1 |
| Iida, Y; Kawashima, H; Kitamura, Y; Mukai, T; Ogawa, M; Saji, H; Shimazu, S; Yoneda, F | 1 |
| Mohanakumar, KP; Muralikrishnan, D; Samantaray, S | 1 |
| Iida, Y; Ogawa, M; Saji, H; Shimazu, S; Takahata, K; Yoneda, F | 1 |
| Iida, Y; Saji, H; Shimazu, S; Takahata, K; Tamashiro, A; Yoneda, F | 1 |
| Ashmeade, TE; Austin, AA; Billinton, A; Hows, ME; Organ, AJ; Perren, MJ; Shah, AJ; Virley, DJ | 1 |
| Mitsumoto, Y; Mori, A; Moriizumi, T; Nakai, M; Ohashi, S | 1 |
| Baranowski, TC; Blavo, DO; Cato, C; Doan, TN; McKinley, ET; Rubinstein, AL | 1 |
| Ishikawa, M; Kitagawa, H; Koga, K; Kurihara, N; Mitsumoto, Y; Mori, A; Nakai, M; Ohashi, S | 1 |
| Brackenborough, KT; Chapman, H; Pangalos, MN; Perren, MJ; Quinn, LP; Upton, N; Vidgeon-Hart, M; Virley, DJ; Woodhams, PL | 1 |
| Ando, K; Higuchi, M; Inaji, M; Maeda, J; Obayashi, S; Okauchi, T; Suhara, T; Tanioka, Y | 1 |
| He, XJ; Nakayama, H; Uetsuka, K | 1 |
| Choudhury, ME; Kubo, M; Nagai, M; Nishikawa, N; Nomoto, M; Yabe, H | 1 |
| Ito, T; Nakayama, H; Suzuki, K; Uchida, K | 1 |
| Guillén, H; Herraiz, T | 1 |
| Herraiz, T | 1 |
| Bai, Y; Cai, D; Zhao, Q | 1 |
| Baskin, AM; Baskin, DS; Han, J; Sharpe, MA | 1 |
| Jang, CG; Jeong, JH; Kim, HC; Lee, JW; Lee, PH; Nabeshima, T; Nam, Y; Nguyen, PT; Oh, YJ; Shin, EJ; Tran, TV; Yoo, JE; Youdim, MBH | 1 |
| Chen, NH; Heng, Y; Huang, JY; Mou, Z; Yuan, YH; Zhang, QS | 1 |
| Mishra, KP; Niranjan, R; Thakur, AK | 1 |
| Guo, K; Jin, M; Li, L; Liu, D; Luo, N; Rong, H; Wang, J; Zhang, J; Zhang, X; Zhang, Y | 1 |
13 review(s) available for selegiline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
Selegiline--an overview of its role in the treatment of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Humans; Monoamine Oxidase; Parkinson Disease; Selegiline | 1992 |
Deprenyl: protective vs. symptomatic effect.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Humans; MPTP Poisoning; Parkinson Disease; Selegiline | 1991 |
The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine; Ergolines; Humans; Levodopa; Macaca mulatta; Neural Pathways; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Quinpirole; Rats; Saimiri; Selegiline; Species Specificity; Substantia Nigra | 1986 |
The role of MAO in MPTP toxicity--a review.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chemical Phenomena; Chemistry; Haplorhini; Hydrogen Peroxide; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroglia; Neurons; Oxidation-Reduction; Parkinson Disease; Pyridines; Rats; Selegiline; Species Specificity; Structure-Activity Relationship; Substrate Specificity | 1986 |
R-(-)-deprenyl and parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benserazide; Clorgyline; Dopamine; Drug Therapy, Combination; Humans; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1987 |
Deprenyl as prophylaxis against Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Parkinson Disease; Phenethylamines; Pyridines; Selegiline | 1988 |
Influence of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, lipoic acid and L-deprenyl on the interplay between cellular redox systems.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Humans; Neurons; Oxidation-Reduction; Oxidative Stress; Selegiline; Thioctic Acid | 1994 |
Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamines; Animals; Corpus Striatum; Dopamine Antagonists; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; Pargyline; Rats; Rats, Inbred Strains; Selegiline | 1994 |
What is it that l-deprenyl (selegiline) might do?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Humans; Monoamine Oxidase Inhibitors; Nervous System; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1994 |
Selegiline can mediate neuronal rescue rather than neuronal protection.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Isoenzymes; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Motor Neurons; Nerve Degeneration; Parkinson Disease, Secondary; Selegiline; Substantia Nigra | 1993 |
Nigral degeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Haplorhini; Humans; Isoenzymes; Monoamine Oxidase; Nerve Degeneration; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Selegiline; Substantia Nigra | 1993 |
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aging; Animals; Biological Transport; Humans; Mitochondria; Nervous System; Oxidation-Reduction; Parkinson Disease; Selegiline; Species Specificity | 1993 |
Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines; new MAO-B inhibitors without amphetamine-like properties.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Cell Count; Cerebral Cortex; Hippocampus; Mice; Monoamine Oxidase Inhibitors; Rats; Selegiline | 1995 |
4 trial(s) available for selegiline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
Big first scored with nerve diseases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Designer Drugs; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline; Substantia Nigra | 1989 |
The effect of deprenyl (selegiline) on the natural history of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Random Allocation; Selegiline | 1989 |
R-(-)-deprenyl as a possible protective agent in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Levodopa; Models, Theoretical; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline | 1987 |
Clinical trial for Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Levodopa; Models, Neurological; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Prospective Studies; Pyridines; Pyridinium Compounds; Selegiline | 1985 |
120 other study(ies) available for selegiline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
c-fos mRNA in mouse brain after MPTP treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blotting, Northern; Brain; Dose-Response Relationship, Drug; Genes, fos; Kinetics; Male; Mazindol; Mice; Neurotoxins; Organ Specificity; Pargyline; Reference Values; RNA; RNA, Messenger; Selegiline; Time Factors | 1992 |
Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Dialysis; Free Radicals; Hydroxides; Hydroxyl Radical; Rats; Selegiline | 1992 |
Differential effects of deprenyl and MPTP on catecholamines and activity in BALB/c mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Hippocampus; Male; Mice; Mice, Inbred BALB C; Motor Activity; Norepinephrine; Selegiline | 1992 |
MPTP-induced ATP loss in mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Animals; Brain; Corpus Striatum; Male; Mice; Mice, Inbred C57BL; Organ Specificity; Selegiline | 1992 |
Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Count; Cell Survival; Mice; Mice, Inbred C57BL; Neurons; Parkinson Disease, Secondary; Selegiline; Sodium Chloride; Substantia Nigra; Tyrosine 3-Monooxygenase | 1991 |
Effects of L-deprenyl and amantadine in an MPTP-model of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Amantadine; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Drug Interactions; Female; Gerbillinae; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Parkinson Disease, Secondary; Selegiline; Serotonin | 1990 |
Persistent depletion of striatal dopamine and cortical norepinephrine in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-3-pyridinol (MPTP-3-OL), an analog of MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain Chemistry; Catecholamines; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Norepinephrine; Selegiline | 1992 |
Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Survival; Clone Cells; Clorgyline; Isoenzymes; Kinetics; Monoamine Oxidase; Neuroblastoma; Neurons; Selegiline | 1991 |
Chemically induced Parkinson's disease. III: A study of a possible role of singlet molecular oxygen in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Free Radicals; Lasers; Monoamine Oxidase; Oxygen; Pargyline; Parkinson Disease; Radiation-Sensitizing Agents; Selegiline | 1991 |
Characterization of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) binding sites in C57BL/6 mouse brain: mutual effects of monoamine oxidase inhibitors and sigma ligands on MPTP and sigma binding sites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Membrane; Clorgyline; Kinetics; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Receptors, Opioid; Receptors, sigma; Selegiline | 1991 |
Preproenkephalin mRNA and methionine-enkephalin increase in mouse striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; G(M1) Ganglioside; Immunologic Techniques; Male; Mice; Mice, Inbred Strains; Nomifensine; Protein Precursors; RNA, Messenger; Selegiline | 1991 |
Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Biotransformation; Cells, Cultured; Clorgyline; Cytochrome P-450 Enzyme System; Mice; Monoamine Oxidase; Oxygenases; Selegiline | 1991 |
Novel effects of MPTP: MAO-B unrelated opioidergic activity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analgesia; Animals; Female; Isoenzymes; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Naloxone; Narcotics; Posture; Reference Values; Selegiline | 1991 |
Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; MPTP Poisoning; NADPH-Ferrihemoprotein Reductase; Pargyline; Phenobarbital; Piperazines; Piperonyl Butoxide; Proadifen; Selegiline | 1991 |
Inhibition of human benzylamine oxidase (BzAO) by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benzylamine Oxidase; Carbidopa; Dopamine Agents; Humans; Kinetics; Parkinson Disease; Selegiline | 1990 |
[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Phenethylamines; Radioimmunoassay; Selegiline | 1990 |
Ro 19-6327, a reversible and highly selective monoamine, oxidase B inhibitor: a novel tool to explore the MAO-B function in humans.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dose-Response Relationship, Drug; Humans; Isoenzymes; Liver; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Picolinic Acids; Rats; Selegiline | 1990 |
Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Survival; Fluorescent Dyes; Fructose; In Vitro Techniques; Intracellular Membranes; Liver; Male; Membrane Potentials; Mitochondria, Liver; MPTP Poisoning; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Selegiline | 1990 |
Tissue concentrations of MPTP and MPP+ after administration of lethal and sublethal doses of MPTP to mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Administration, Oral; Animals; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Male; Mice; Monoamine Oxidase; MPTP Poisoning; Selegiline; Tissue Distribution | 1990 |
Monoamine oxidase and the bioactivation of MPTP and related neurotoxins: relevance to DATATOP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Humans; In Vitro Techniques; Male; Mice; Monoamine Oxidase; Nervous System; Neurotoxins; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Inbred Strains; Selegiline; Vitamin E | 1990 |
Behavioral and biochemical changes following acute administration of MPTP and MPP+.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Desipramine; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Motor Activity; Nomifensine; Pyridines; Pyridinium Compounds; Selegiline; Serotonin | 1987 |
The effect of MPTP on uridine uptake in murine nerve cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Male; Mice; Mice, Inbred Strains; Organ Specificity; Pyridines; Reference Values; RNA; Selegiline; Substantia Nigra; Uridine | 1988 |
Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Male; Mice; Mice, Inbred BALB C; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline; Time Factors | 1989 |
Sodium diethyldithiocarbamate protects against the MPTP-induced inhibition of immune responses in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; B-Lymphocytes; Corpus Striatum; Designer Drugs; Ditiocarb; Dopamine; Homovanillic Acid; Immune System; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Metallothionein 3; Mice; Mitogens; Pyridines; Selegiline; T-Lymphocytes | 1989 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits proton motive force in energized liver mitochondria.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Action Potentials; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Energy Metabolism; Hydrogen-Ion Concentration; Male; Membrane Potentials; Mitochondria, Liver; Neurotoxins; Protons; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline | 1989 |
A high dose of MPTP overcomes the protective effect of selegiline against dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Phenethylamines; Pyridines; Receptors, Dopamine; Selegiline | 1989 |
Benztropine inhibits toxicity of MPTP in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benztropine; Corpus Striatum; Dopamine; Female; Humans; Mice; Pyridines; Selegiline; Tropanes | 1985 |
MPTP, selegiline, and parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Humans; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline | 1987 |
Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzamides; Brain; Corpus Striatum; Dopamine; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Agents; Parkinson Disease, Secondary; Pyridines; Rats; Selegiline; Substantia Nigra; Tyramine | 1987 |
The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Membrane Permeability; Cell Survival; Cytosol; Liver; Male; Mitochondria; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline | 1988 |
Monoamine oxidase B(MAO-B) is the major catalyst for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation in human brain and other tissues.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Humans; In Vitro Techniques; Isoenzymes; Mice; Monoamine Oxidase; Oxidation-Reduction; Phenethylamines; Pyridines; Pyridinium Compounds; Rats; Selegiline; Species Specificity | 1986 |
Prevention of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic toxicity in mice by MDL 72145, a selective inhibitor of MAO-B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Allylamine; Amines; Animals; Brain; Clorgyline; Dopamine; Male; Mice; Mitochondria; Monoamine Oxidase Inhibitors; Pyridines; Selegiline | 1986 |
Involvement of monoamine oxidase enzymes in the action of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, a selective neurotoxin, in the squirrel monkey: binding and biochemical studies.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Brain; Dopamine; Isoenzymes; Male; Monoamine Oxidase; Organ Specificity; Pyridines; Saimiri; Selegiline | 1986 |
MPTP: clinical implications.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Basal Ganglia; Benserazide; Drug Combinations; Drug Therapy, Combination; Humans; Hydrazines; Levodopa; Parkinson Disease; Phenethylamines; Pyridines; Selegiline | 1986 |
Depletion of norepinephrine in mouse heart by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mimicked by 1-methyl-4-phenylpyridinium (MPP+) and not blocked by deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Heart; Mice; Myocardium; Norepinephrine; Phenethylamines; Pyridines; Pyridinium Compounds; Selegiline | 1986 |
(-)Deprenyl in perspective: prophylaxis for Parkinson's disease?
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Arylsulfotransferase; Blood Platelets; Humans; Monoamine Oxidase; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline; Sulfurtransferases; Tomography, Emission-Computed | 1986 |
Primate-rodent 3H-MPTP binding differences, and biotransformation of MPTP to a reactive intermediate in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Biotransformation; Brain; Clorgyline; In Vitro Techniques; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains; Saimiri; Selegiline | 1986 |
The pharmacology of (-)deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Aging; Animals; Catecholamines; Corpus Striatum; Dopamine; Humans; Hydroxydopamines; In Vitro Techniques; Monoamine Oxidase; Oxidopamine; Phenethylamines; Pyridines; Selegiline | 1986 |
Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biological Transport; Brain Chemistry; Bridged Bicyclo Compounds; Cerebral Cortex; Corpus Striatum; Dopamine; Isomerism; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Nucleus Accumbens; Pyridines; Selegiline; Structure-Activity Relationship | 1987 |
MPTP, MPP+ and mitochondrial function.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Corpus Striatum; Glycolysis; In Vitro Techniques; Kinetics; Liver; Mice; Mitochondria; Oxygen Consumption; Pyridines; Pyridinium Compounds; Rats; Selegiline; Structure-Activity Relationship | 1987 |
Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clorgyline; Female; Half-Life; Isoenzymes; Kinetics; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Phenethylamines; Placenta; Pregnancy; Pyridines; Rats; Selegiline; Serotonin | 1986 |
MAO type B inhibitors as adjunct to L-dopa therapy.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkynes; Animals; Brain; Drug Therapy, Combination; Humans; Indans; Isoenzymes; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Receptors, Dopamine; Selegiline; Structure-Activity Relationship; Tyramine | 1987 |
Studies on the mechanism of the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred Strains; Pyridines; Pyridinium Compounds; Receptors, Dopamine; Selegiline | 1987 |
Parkinson's disease: current view.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Selegiline; Substantia Nigra; Tomography, Emission-Computed | 1987 |
Metabolism of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a rat pheochromocytoma cell line, PC12h.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Clorgyline; Culture Media; Monoamine Oxidase; Neurons; Osmolar Concentration; Pheochromocytoma; Pyridines; Pyridinium Compounds; Rats; Selegiline; Tumor Cells, Cultured | 1987 |
Different effects of monoamine oxidase inhibition on MPTP depletion of heart and brain catecholamines in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cyclopropanes; Dopamine; Liver; Male; Mice; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Oxidation-Reduction; Pargyline; Pyridines; Selegiline | 1988 |
Selegiline and the prophylaxis of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chemical Phenomena; Chemistry; Humans; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Tissue Distribution | 1987 |
Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Clorgyline; Corpus Striatum; Dopamine; Haplorhini; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neural Pathways; Neurotoxins; Pyridines; Selegiline | 1988 |
Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Clorgyline; Male; Mice; Monoamine Oxidase; Oxidation-Reduction; Pyridines; Selegiline; Structure-Activity Relationship | 1988 |
L-deprenyl in prevention of MPTP induced depletion of striatal enkephalins in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1988 |
[3H]tryptamine binding sites are not identical to monoamine oxidase in rat brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Brain; Clorgyline; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Synaptosomes; Tissue Distribution; Tryptamines | 1988 |
Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Bridged Bicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Isoenzymes; Lethal Dose 50; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Pyridines; Pyridinium Compounds; Salivation; Selegiline | 1988 |
Disposition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice before and after monoamine oxidase and catecholamine reuptake inhibition.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Glands; Animals; Autoradiography; Brain; Catecholamines; Clorgyline; Female; Image Processing, Computer-Assisted; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Pyridines; Scintillation Counting; Selegiline; Tissue Distribution | 1988 |
MPTP and MPTP analogs induced cell death in cultured rat hepatocytes involving the formation of pyridinium metabolites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Survival; Glutathione; Liver; Male; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Selegiline | 1988 |
Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the mouse: relationships between monoamine oxidase, MPTP metabolism and neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Benzylamines; Clorgyline; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Pyridines; Selegiline; Substantia Nigra; Synaptosomes; Tryptamines | 1985 |
Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Culture Techniques; Female; Kinetics; Monoamine Oxidase; Pargyline; Pregnancy; Pyridines; Rats; Selegiline; Substantia Nigra | 1985 |
Deprenyl selectively inhibits [3H]MPTP binding sites in monkey brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Brain; In Vitro Techniques; Phenethylamines; Pyridines; Saimiri; Selegiline; Tritium | 1985 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correspondence of its binding sites to monoamine oxidase in rat brain, and inhibition of dopamine oxidative deamination in vivo and in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Clorgyline; Corpus Striatum; Deamination; Dopamine; In Vitro Techniques; Male; Monoamine Oxidase; Oxidation-Reduction; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline; Subcellular Fractions | 1985 |
Studies on the oxidation of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Allylamine; Animals; Benzylamines; Brain; Clorgyline; Indans; Kinetics; Mice; Mice, Inbred C57BL; Mitochondria; Monoamine Oxidase; Oxidation-Reduction; Pyridines; Selegiline; Tryptamines | 1985 |
Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; Neurons; Phenethylamines; Pyridines; Pyridinium Compounds; Rats; Selegiline; Synaptosomes | 1985 |
Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzylamines; Brain; Dopamine; Indans; Indenes; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pargyline; Pyridines; Selegiline; Tryptamines | 1985 |
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Brain; Kinetics; Male; Mitochondria; Monoamine Oxidase; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Selegiline | 1984 |
MPTP parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adult; Animals; Humans; Male; Mice; Parkinson Disease, Secondary; Pyridines; Saimiri; Selegiline; Substance-Related Disorders | 1984 |
Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caudate Nucleus; Dopamine; Female; Homovanillic Acid; Macaca fascicularis; Pargyline; Parkinson Disease, Secondary; Phenethylamines; Pyridines; Selegiline | 1984 |
Effects of deprenyl on monoamine oxidase and neurotransmitters in the brains of MPTP-treated aging mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Corpus Striatum; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Neurotransmitter Agents; Olfactory Pathways; Selegiline | 1995 |
Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Catalase; Glutathione Peroxidase; Lipid Peroxides; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Selegiline; Superoxide Dismutase | 1995 |
Age-dependent effects of the 2'-methyl analog of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine: prevention by inhibitors of monoamine oxidase B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Clorgyline; Corpus Striatum; Dopamine; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Selegiline | 1995 |
Inhibition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolic activity of porcine FAD-containing monooxygenase by selective monoamine oxidase-B inhibitors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Female; Microsomes, Liver; Monoamine Oxidase Inhibitors; Oxygenases; Pargyline; Selegiline; Substrate Specificity; Swine | 1995 |
1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol inhibits tyrosine hydroxylase activity in rat striatal synaptosomes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Chromatography, High Pressure Liquid; Clorgyline; Corpus Striatum; Dopamine; Isoquinolines; Monoamine Oxidase; NAD; Nerve Tissue Proteins; Nomifensine; Parkinson Disease; Rats; Selegiline; Sulpiride; Synaptosomes; Tyrosine 3-Monooxygenase | 1994 |
Interactions among deprenyl, clorgyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on catecholamines in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain Chemistry; Catecholamines; Clorgyline; Dopamine; Dopamine Agents; Drug Interactions; Hippocampus; Male; Mice; Mice, Inbred BALB C; MPTP Poisoning; Neostriatum; Norepinephrine; Selegiline; Serotonin | 1994 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutamate and aspartate in the mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain Chemistry; Deoxyglucose; Energy Metabolism; Glutamic Acid; Male; Mazindol; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Selegiline | 1994 |
A study of the biological pharmacology of IFO, a new selective and reversible monoamine oxidase-B inhibitor.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Monoamines; Brain; Dopamine; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neostriatum; Nervous System Diseases; Oxadiazoles; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Selegiline | 1994 |
The histochemical demonstration of MPTP oxidation in the postmortem human striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Caudate Nucleus; Cerebrovascular Disorders; Clorgyline; Corpus Striatum; Dopamine Agents; Female; Glial Fibrillary Acidic Protein; Histocytochemistry; Humans; Male; Monoamine Oxidase; Neuroglia; Oxidation-Reduction; Putamen; Selegiline | 1993 |
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors | 1993 |
An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Catalase; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Lipid Peroxides; MPTP Poisoning; Neurons; Pargyline; Rats; Reactive Oxygen Species; Selegiline; Superoxide Dismutase; Tumor Cells, Cultured | 1993 |
MPTP neurotoxicity to cerebellar Purkinje cells in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benztropine; Dose-Response Relationship, Drug; Male; Mazindol; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Neurotoxins; Pargyline; Purkinje Cells; Selegiline | 1993 |
Selegiline is neuroprotective in primary brain cultures treated with 1-methyl-4-phenylpyridinium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Dopamine; Dopamine Agents; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Selegiline; Tyrosine 3-Monooxygenase | 1996 |
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Ditiocarb; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nicotine; Piperazines; Selegiline; Serotonin | 1996 |
Genetic elevation of monoamine oxidase levels in dopaminergic PC12 cells results in increased free radical damage and sensitivity to MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Survival; Dopamine; Dopamine Agents; Free Radicals; Gene Expression Regulation, Enzymologic; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotoxins; PC12 Cells; Plasmids; Rats; Selegiline; Sensitivity and Specificity; Vitamin E | 1996 |
L-Deprenyl and MDL72974 do not improve the recovery of dopaminergic cells following systemic administration of MPTP in mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Allyl Compounds; Animals; Butylamines; Cell Count; Corpus Striatum; Dopamine; Dopamine Agents; Drug Evaluation, Preclinical; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Selegiline | 1997 |
Systemic administration of MPTP induces thalamic neuronal degeneration in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dizocilpine Maleate; Dopamine Agents; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurons; Neuroprotective Agents; Nomifensine; Selegiline; Substantia Nigra; Temperature; Thalamus | 1997 |
MPTP-induced deficits in motor activity: neuroprotective effects of the spintrapping agent, alpha-phenyl-tert-butyl-nitrone (PBN).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cyclic N-Oxides; Dopamine; Free Radical Scavengers; Hypokinesia; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitrogen Oxides; Selegiline; Spin Trapping | 1997 |
Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Dogs; Dopamine; Dopamine Agents; Homovanillic Acid; MPTP Poisoning; Neurons; Neuroprotective Agents; Organ Culture Techniques; Selegiline; Substantia Nigra | 1997 |
The effects of L-deprenyl treatment, alone and combined with GM1 ganglioside, on striatal dopamine content and substantia nigra pars compacta neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Dopamine Agents; G(M1) Ganglioside; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neurons; Selegiline; Substantia Nigra | 1998 |
Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Line; Dopamine; G(M1) Ganglioside; Glial Cell Line-Derived Neurotrophic Factor; Glutathione Peroxidase; Lipid Peroxidation; Male; Melatonin; Monoamine Oxidase; Neostriatum; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selegiline; Superoxide Dismutase | 1998 |
The amphetamine-like reinforcing effect and mechanism of L-deprenyl on conditioned place preference in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Conditioning, Operant; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Reinforcement, Psychology; Selegiline | 1999 |
Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against MPTP-induced dopaminergic toxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dopamine; Female; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Random Allocation; Selegiline; Time Factors | 1999 |
Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cattle; Clorgyline; Dogs; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Papio; Rabbits; Rats; Rats, Sprague-Dawley; Selegiline; Species Specificity; Spectrophotometry | 1999 |
Neuroprotection by (R)-deprenyl and 7-nitroindazole in the MPTP C57BL/6 mouse model of neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Cattle; Corpus Striatum; Dopamine; Indazoles; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Neuroprotective Agents; Neurotoxins; Selegiline | 1999 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on differentiating mouse N2a neuroblastoma cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Actins; Animals; Axons; Blotting, Western; Bucladesine; Cell Death; Cell Differentiation; Culture Media, Serum-Free; Mice; Monoamine Oxidase; Neuroblastoma; Neurofilament Proteins; Neurons; Neuroprotective Agents; Phosphorylation; Selegiline; Subcellular Fractions; Tubulin; Tumor Cells, Cultured | 2000 |
MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carbazoles; Corpus Striatum; Enzyme Activation; Enzyme Inhibitors; Indoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Selegiline; Signal Transduction; Substantia Nigra | 2000 |
Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Selegiline | 2000 |
SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antioxidants; Catalase; Dopamine Agents; Dopamine Agonists; Glutathione; Mice; Mice, Inbred BALB C; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neostriatum; Nerve Tissue Proteins; Neurotoxicity Syndromes; Selegiline; Superoxide Dismutase | 2001 |
Effects of MAO inhibitors upon MPTP mice chronically treated with suprathreshold doses of L-dopa.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Clorgyline; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Levodopa; Locomotion; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Phenelzine; Phenethylamines; Selegiline; Thiazoles; Tryptamines | 2000 |
Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Indoles; Male; Methylamines; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinsonian Disorders; Selegiline | 2000 |
Selective inhibition of MAO-B through chronic low-dose (R)-deprenyl treatment in C57BL/6 mice has no effect on basal neostriatal dopamine levels.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinsonian Disorders; Selegiline | 2001 |
Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Weight; Callithrix; Disease Models, Animal; Dopamine; Dopamine Agents; Female; Immunohistochemistry; Indans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Neostriatum; Neurons; Norepinephrine; Parkinsonian Disorders; Selegiline; Serotonin; Substantia Nigra | 2001 |
Eldepryl prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral neuronal apoptosis in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Behavior, Animal; Flow Cytometry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; PC12 Cells; Rats; Selegiline; Substantia Nigra | 2001 |
Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Behavior, Animal; Catecholamines; Dopamine; Dopamine Agents; Glutathione; Male; Neostriatum; Oxidation-Reduction; Parkinson Disease, Secondary; Rats; Rats, Wistar; Selegiline; Stereotaxic Techniques | 2002 |
In vivo imaging of brain dopaminergic neurotransmission system in small animals with high-resolution single photon emission computed tomography.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Callithrix; Dopamine; Iodine Radioisotopes; Motor Activity; Radioligand Assay; Selegiline; Synaptic Transmission; Tomography, Emission-Computed, Single-Photon | 2003 |
D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Dopamine; Dose-Response Relationship, Drug; Hydroxyl Radical; Isomerism; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Neostriatum; Neural Pathways; Neurons; Neuroprotective Agents; Neurotoxins; Parkinsonian Disorders; Selegiline; Substantia Nigra | 2003 |
Effects of monoamine oxidase inhibitors on the diethyldithiocarbamate-induced enhancement of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in C57BL/6 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Weight; Cell Death; Clorgyline; Disease Models, Animal; Ditiocarb; Dopamine; Down-Regulation; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neostriatum; Neuroprotective Agents; Parkinsonian Disorders; Presynaptic Terminals; Selegiline; Substantia Nigra | 2003 |
Recovery of motor function and dopaminergic parameters in a mouse model of Parkinson's disease induced by co-administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Ditiocarb; Dopamine; Drug Synergism; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Parkinsonian Disorders; Reaction Time; Recovery of Function; Selegiline; Serotonin | 2003 |
High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Mice; Reproducibility of Results; Selegiline; Sensitivity and Specificity; Time Factors; Tissue Distribution | 2004 |
Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Bromocriptine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Hindlimb Suspension; Immobility Response, Tonic; Immunohistochemistry; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Nerve Tissue Proteins; Selegiline; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Targeting; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; MPTP Poisoning; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nomifensine; Oligodeoxyribonucleotides, Antisense; Selegiline; Species Specificity; Swimming; Tyrosine 3-Monooxygenase; Zebrafish | 2005 |
H MRS identifies lactate rise in the striatum of MPTP-treated C57BL/6 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Piperazines; Protons; Selegiline; Time Factors | 2006 |
A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Ethology; Gait Disorders, Neurologic; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neural Pathways; Neuropharmacology; Parkinsonian Disorders; Predictive Value of Tests; Selegiline; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; Caudate Nucleus; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Female; Injections, Subcutaneous; Male; Motor Activity; Motor Skills; Parkinsonian Disorders; Postural Balance; Premedication; Putamen; Radioligand Assay; Selegiline; Substantia Nigra | 2008 |
Neural progenitor cells are protected against MPTP by MAO-B inhibitors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adult Stem Cells; Age Factors; Animals; Animals, Newborn; Apoptosis; Benzamides; Cell Count; Cerebral Ventricles; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Neurons; Neurotoxins; Selegiline; Tyrosine 3-Monooxygenase | 2008 |
Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Biogenic Amines; Brain Chemistry; Callithrix; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Homovanillic Acid; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neostriatum; Neurons; Selegiline; Zonisamide | 2009 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuroblastic apoptosis in the subventricular zone is caused by 1-methy-4-phenylpiridinium (MPP(+)) converted from MPTP through MAO-B.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cerebral Ventricles; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Doublecortin Protein; Ependyma; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microtubule-Associated Proteins; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neural Stem Cells; Neuropeptides; Selegiline | 2012 |
Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antioxidants; Carbolines; Chromatography, High Pressure Liquid; Harmine; Humans; Indazoles; Mass Spectrometry; Methylene Blue; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction; Selegiline | 2011 |
Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Chromatography, High Pressure Liquid; Clorgyline; Enzyme Assays; Harmine; Humans; Indazoles; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Nicotiana; Oxidation-Reduction; Pyridinium Compounds; Recombinant Proteins; Selegiline; Smoke; Vitamin K 3 | 2012 |
Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; bcl-2-Associated X Protein; Disease Models, Animal; Dopaminergic Neurons; Gait; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Parkinson Disease; Real-Time Polymerase Chain Reaction; RNA, Messenger; Selegiline | 2013 |
Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antineoplastic Agents; Drug Delivery Systems; Drug Design; Glioma; Humans; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Prodrugs; Selegiline | 2015 |
N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-X Protein; Behavior, Animal; Caspase 3; Conditioning, Psychological; Cytochromes c; Cytosol; Dopaminergic Neurons; Electron Transport Complex I; Locomotion; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria; Monoamine Oxidase; Neostriatum; Oxidation-Reduction; Oxidative Stress; Phenethylamines; Protein Binding; Selegiline; Sulfonamides; Superoxide Dismutase; Tumor Suppressor Protein p53; Uncoupling Protein 2 | 2016 |
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Antiparkinson Agents; Astrocytes; Behavior, Animal; Benserazide; Benzothiazoles; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Drug Combinations; Levodopa; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Parkinsonian Disorders; Pramipexole; Selegiline | 2017 |
Inhibition of Cyclooxygenase-2 (COX-2) Initiates Autophagy and Potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Autophagy; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Lipopolysaccharides; Nerve Tissue Proteins; Neuroblastoma; Parkinson Disease; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Selegiline; Sulfonamides | 2018 |
Neuroprotective effect of paeoniflorin in the mouse model of Parkinson's disease through α-synuclein/protein kinase C δ subtype signaling pathway.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Apoptosis; Disease Models, Animal; Glucosides; Mice; Microscopy, Electron, Transmission; Monoterpenes; Neurotoxins; Parkinsonian Disorders; Protein Kinase C-delta; Rotarod Performance Test; Selegiline; Substantia Nigra | 2021 |