secoisolariciresinol-diglucoside and ferulic-acid

secoisolariciresinol-diglucoside has been researched along with ferulic-acid* in 2 studies

Other Studies

2 other study(ies) available for secoisolariciresinol-diglucoside and ferulic-acid

ArticleYear
Comparison of phytochemical profiles and health benefits in fiber and oil flaxseeds (Linum usitatissimum L.).
    Food chemistry, 2017, Jan-01, Volume: 214

    Flaxseed (Linum usitatissimum L.) is a rich source of nutritive and bioactive compounds. The research evaluated the disparity in phytochemical profiles along with total and cellular antioxidant activities between oil and fiber flaxseeds. There were significant differences in total phenolics, total flavonoids and antioxidant activities among the six cultivars of fiber and oil flaxseed, respectively. Four phytochemical compounds including caffeic acid, p-coumaric acid and ferulic acid, and secoisolariciresinol diglucoside (SDG) were identified and quantified in the cultivars of oil and fiber flaxseed by HPLC analysis. Notably, the average of total phenolic and flavonoid contents, along with total antioxidant activities between fiber and oil flaxseeds were not different significantly; even the cellular antioxidant activity of fiber flaxseed was superior to oil flaxseed. These results suggest that fiber flaxseeds would be valuable candidates as functional products and dietary supplements production owing to the higher bioactive values as well as oil flaxseeds.

    Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Coumaric Acids; Dietary Fiber; Flavonoids; Flax; Glucosides; Linseed Oil; Phenols; Phytochemicals; Propionates; Seeds

2017
Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats.
    The British journal of nutrition, 2004, Volume: 92, Issue:1

    Secoisolariciresinol diglucoside (SDG) is an important dietary lignan that is found at very high levels in flaxseed (1-4 %, w/w). Flaxseed lignans have received much research interest in recent years because of reported phyto-oestrogenic, anticarcinogenic, and anti-atherogenic effects. Previously, flaxseed feeding has been shown to decrease vitamin E concentrations in rats despite the antioxidant potential of SDG in vitro. Sesamin, a sesame lignan, on the other hand has been shown to increase vitamin E concentrations in rats. The aim of the present study was to investigate the effect of dietary SDG and its oligomers on vitamin E and cholesterol concentrations in rats. SDG was extracted from defatted flaxseed flour with a dioxane-ethanol mixture and purified by silica column chromatography. The major oligomers with 3-hydroxy-3-methyl glutaric acid, containing a high ratio of SDG to p-coumaric and ferulic acid glucosides, were purified from the extracts by reversed-phase liquid chromatography. When fed to rats at 0.1 % in the diet for 27 d, both SDG and its oligomers had no effect on animal performance but caused an increase in liver cholesterol and a 2-fold reduction in the levels of alpha- and gamma-tocopherols in rat plasma and liver. It is notable that a phenolic antioxidant, such as SDG, causes a vitamin E-lowering effect in rats. This cannot be explained at present, but warrants further investigations with respect to the magnitude, mechanism, and significance of the observed effect for human nutrition.

    Topics: Animals; Anticholesteremic Agents; Antioxidants; Butylene Glycols; Cholesterol; Chromatography, High Pressure Liquid; Coumaric Acids; Diet; Flax; Free Radical Scavengers; Glucosides; Liver; Meglutol; Propionates; Rats; Rats, Sprague-Dawley; Seeds; Tocopherols; Vitamin E

2004