secnidazole has been researched along with metronidazole in 117 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (5.13) | 18.7374 |
| 1990's | 22 (18.80) | 18.2507 |
| 2000's | 22 (18.80) | 29.6817 |
| 2010's | 47 (40.17) | 24.3611 |
| 2020's | 20 (17.09) | 2.80 |
| Authors | Studies |
|---|---|
| Azas, N; Botta, C; Chapelle, O; Crozet, MD; Curti, C; De Méo, M; Gasquet, M; Hutter, S; Rémusat, V; Vanelle, P | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Ang, CW; Blaskovich, MAT; Cooper, MA; Jarrad, AM | 1 |
| Hart, CJS; Riches, A; Skinner-Adams, TS; Trenholme, KR | 1 |
| Beteck, RM; Jesumoroti, OJ; Legoabe, LJ; Patel, OPS | 1 |
| Catalan, F; Niel, G; Siboulet, A; Videau, D | 1 |
| Daujat, M; Domergue, J; Fabre, I; Joyeux, H; Maurel, P; Maurice, M; Pichard, L | 1 |
| Chochillon, C; Favennec, L; Gobert, JG; Magne, D; Meillet, D; Raichvarg, D; Savel, J | 1 |
| Latonio, AA | 1 |
| Fadillah, A; Sidabutar, P; Soedin, K; Syukran, OK | 1 |
| Cho, YW; Maisonneuve, H; Rossignol, JF | 1 |
| Bhatia, SC; Shanbhag, VD | 1 |
| Decouvelaere, B; Pasquier, P; Populaire, P; Renard, A | 1 |
| Khamseh, M; Omrani, G; Rastegar-Lari, A | 1 |
| Dilmen, U; Kaya, IS; Kitapçi, F; Senses, DA; Toppare, MF; Yalcinkaya, F | 1 |
| Alkan, MZ; Atambay, M; Gürüz, Y; Ozbel, Y; Ozbilgin, A; Ozcel, MA; Tasçi, S | 1 |
| Ahmed, W; Baqai, R; Qureshi, H; Qureshi, SA; Zuberi, SJ | 1 |
| Cuisinier, FJ; Frydman, A; Le Liboux, A; Montay, G; Pichard, E; Tenenbaum, H | 1 |
| Rastegar-Lari, A; Salek-Moghaddam, A | 1 |
| Gillis, JC; Wiseman, LR | 1 |
| Baqai, R; Qureshi, H; Zuberi, SJ | 1 |
| Naidu, MU; Rani, PU; Rao, TR; Ravi, SK; Sekhar, EC; Shobha, JC; Surya, KJ | 1 |
| Buitrón García Figueroa, R; Gonzalo Butrón López, F; Oropez Rechy, G; Romero-Cabello, R | 1 |
| Bhatia, S; Karnad, DR; Oak, JL | 1 |
| Feliu, C; Fernández, J; Gómez, MS; Gracenea, M | 1 |
| Alvarado García, A; Gaviño Ambriz, S | 1 |
| Kanwar, AJ; Thami, GP | 1 |
| Ahuja, V; Bal, C; Dhar, A; Sharma, MP | 1 |
| Atalay, C; Göl, K; Oztopçu, C; Sahin, I; Saraçoğlu, F; Türkkani, B | 1 |
| Santamarina, MT; Tojo, JL | 1 |
| Brett, AM; Cruz, ML; Gutz, IG; La-Scalea, MA; Serrano, SH | 1 |
| Costa, V; Di Prisco, MC; Jiménez, JC; Lynch, NR; Rodríguez, N | 1 |
| Ahmed, W; Baqai, R; Mehdi, I; Qureshi, H | 1 |
| Hassanein, A; Radi, AE | 1 |
| Abdine, HH; El Wallily, AF; Razak, OA; Zamel, S | 1 |
| Carrillo, M; Costa, V; Di Prisco, MC; Jiménez, JC; Lira, C; López, Y; Rodríguez, N; Silvera, A; Villamizar, J; Zerpa, E | 1 |
| Coşkun, S; Cüneyt Balcioğlu, I; Ertan, P; Girginkardeşler, N; Ok, UZ | 1 |
| Almirall, P; Cañete, R; Cimerman, S; Escobedo, AA; Gonzalez, ME; Pareja, A | 1 |
| Arora, R; Batra, S; Malhotra, M; Sharma, JB; Sharma, S | 1 |
| Abboud, Y; Abourriche, A; Bennamara, A; Berrada, M; Charrouf, M; Saffaj, T | 1 |
| Bakshi, M; Singh, S | 1 |
| Gómez, G; Núñez, JT | 1 |
| Chanana, C; Mittal, S; Raina, U; Sharma, JB | 1 |
| Ortiz-Ibarra, J; Reyna-Figueroa, J; Villagrana-Zesati, R | 1 |
| Gu, Y; Li, X; Ren, H; Sun, J; Wang, G; Xie, H; Yan, B; Zheng, Y | 1 |
| Chen, J; Duan, H; Feng, L; Hu, KL; Jiang, XG; Tao, WX; Zhu, DQ | 1 |
| Abd El-Hady, SS; El-Nabarawi, MA; Gad, HA | 2 |
| Goto, R; Lunn, PG; Mascie-Taylor, CG | 1 |
| Ayala, AP; Chaturvedi, D; Gupta, VP; Honorato, SB; Mishra, S; Siesler, HW; Tandon, P | 1 |
| Qian, XD; Wang, FM; Xu, H; Yu, HY | 1 |
| Capron, M; Convit, J; Dei-Cas, E; Dive, D; Jiménez, JC; Pinon, A | 1 |
| Gulzar A, M; Harish, NM; Narayana, RC; Prabhakara, P; Singh, AK; Subrahmanyam, EV | 1 |
| Acar, J; Brauman, M; De Backer, E; Dubreuil, L; Vaneechoutte, M | 1 |
| Zhang, XX; Zheng, SS; Zhu, MM | 1 |
| Ben Salem, C; Biour, M; Bouraoui, K; Fathallah, N; Raynaud, JJ; Slim, R; Zamy, M | 1 |
| Esparza, J; Leyva, JG; Méndez, RO; Morales, GG; Quihui, L; Valencia, ME | 1 |
| Liao, S; Lin, X; Wang, X; Wu, X; Xie, Z | 1 |
| Baxi, S; Sanmukhani, J; Shah, V; Tripathi, C | 1 |
| Bohbot, JM; Brauman, M; Fagnen, D; Vicaut, E | 1 |
| Alfonso, M; Almirall, P; Avila, I; Cimerman, S; Dawkins, IV; Escobedo, AA; Núñez, FA; Salazar, Y | 1 |
| Li, ZL; Sun, J; Zhang, HJ; Zhu, DD; Zhu, HL | 1 |
| Bertoletti, B; Brendler, S; Castro, VS; Costa, MM; Da Silva, AS; Jaques, JA; Lopes, ST; Mazzanti, CM; Monteiro, SG; Raiser, AG; Tonin, AA; Zanette, RA | 1 |
| Darwish, KM; El-Sadek, M; Mostafa, S; Salama, I | 1 |
| Ghosh, B; Majumdar, S; Roy, S | 1 |
| Andrade, WS; Bezerra, MM; Cavalcanti, PP; Cunha, GH; Fechine, FV; Frota Bezerra, FA; Moraes, ME; Moraes, MO; Pontes, AV | 1 |
| Chauhan, NP; Parikh, RK; Patel, JM; Raval, MK; Sheth, NR; Sorathiya, KR | 1 |
| Barrio, AG; Escribano, AI; García-Trevijano, JA; Marcel, AM; Redó, VJ; Ruiz, JJ; Tugores, YM | 1 |
| Abbas, T; Ali, MM; Avais, M; Ijaz, M; Khan, A; Khan, MS | 1 |
| Li, Y; Ma, HP; Wang, XM; Xue, YR; Zhao, CP; Zhao, MY; Zhu, HL | 1 |
| Ellis, J; Harkness, J; Marriott, D; Roberts, T; Stark, D | 1 |
| Bhuiyan, TR; Choudhury, FK; Khanam, F; Lundgren, A; Qadri, F; Sack, DA; Saha, A; Salma, U; Sayeed, MA; Svennerholm, AM | 1 |
| Deshpande, A; Escobedo, AA; Hernandez, AV; Pasupuleti, V; Roman, Y; Thota, P | 1 |
| Chen, X; Chen, Y; Du, J; Liu, D; Zhang, Y; Zhong, D | 1 |
| Buffon, R; Manzoor, S; Rossi, AV | 1 |
| Kotsiubniak, LA; Koval', VIu; Moskal', OM | 1 |
| Adetoro, N; Braun, CJ; Pentikis, HS | 1 |
| Hernán, A; Jiménez, JC; Núñez, L; Pérez-Chacón, G; Pocaterra, LA; Rojas, E | 1 |
| Adetoro, NA; Braun, CJ; Hillier, SL; Morgan, FG; Nyirjesy, P; Schwebke, JR; Waldbaum, AS | 1 |
| Koltun, W; Morgan, FG; Nyirjesy, P; Schwebke, JR | 1 |
| Adetoro, N; Darpo, B; Matthews, BG; Pentikis, HS; Xue, H | 1 |
| Adetoro, N; Pentikis, HS | 1 |
| Basharat, A; Fahim, A; Khan, DH; Khan, MH; Tariq, N | 1 |
| Chavoustie, SE; Gersten, JK; Samuel, MJ; Schwebke, JR | 1 |
| Nyirjesy, P; Schwebke, JR | 1 |
| Bottari, NB; Campigotto, G; Da Silva, AS; Fortuoso, BF; Glombowsky, P; Lopes, LS; Volpato, A | 1 |
| Baldissera, MD; Bottari, NB; Crecencio, RB; Da Silva, AS; Fortuoso, BF; Machado, G; Morsch, VMM; Pereira, WAB; Ribeiro, MP; Schetinger, MRC; Secco, R; Stefani, LM; Tomasi, T; Volpato, A | 1 |
| Assikar, S; Bédane, C; Charissoux, A; Matei, I; Nespoulous, L | 1 |
| Duan, X; Lin, X; Ruan, Q; Teng, Y; Zhang, J; Zhang, X | 1 |
| Hussar, DA | 1 |
| Abbas, HA; Askoura, MM; Saleh, MM | 1 |
| Almirall, P; Avila, I; Chirino, E; Duque, A; Escobedo, AA; Pacheco, F | 1 |
| Abbas, AM; Badawy, MM; Elghazaly, SM; Hamam, KM; Samy, A; Yakoub Agha, NA | 1 |
| Faught, BM; Reyes, S | 1 |
| Leggit, JC; Saguil, A | 1 |
| Cheung, W; Maher, S; Malik, R; Russo, C; Šlapeta, J | 1 |
| Eckert, LO; Kus, LH; Neal, CM; Peipert, JF | 1 |
| Iza, JA; Iza, SN; Olivera, MJ | 1 |
| Abd El Aziz, MA; Abedi, P; Jahanfar, S; Judge, HM; Sharifipour, F | 1 |
| Clark, CM; Mergenhagen, KA; Russo, TA; Skelly, MK; Wattengel, BA | 1 |
| Brito, K; Cañete, R; Herrera, E; Kofoed, PE; Noda, AL; Rodríguez, M; Ursing, J | 1 |
| Adetoro, N; Levy, S; Pentikis, H; Tipping, D | 1 |
| Chale-Dzul, JB; Colín-Lozano, B; Estrada-Soto, S; Hernández-Martínez, NA; Hernández-Núñez, E; Medina-Franco, JL; Moo-Puc, R; Navarrete-Vázquez, G; Prieto-Martínez, FD; Rocha-Garduño, G | 1 |
| Hossain, MJ; Rashid, MA; Sultan, MZ | 1 |
| Ali, OT; Almalki, AJ; Hassan, WS; Khayyat, AN; Sebaiy, MM | 1 |
| Argenta, DF; Bernardo, BDC; Caon, T; Chamorro, AF; Matos, PR | 1 |
| Abdel Kader, A; El Amir, A; Farid, A; Madbouly, N; Rabee, I | 1 |
| Arbuckle, J; Carter, BA; Chavoustie, SE; Eder, S; Graves, KJ; Kaufman, G; Lazenby, GB; McMahon, CP; Mena, LA; Muzny, CA; Nyirjesy, P; Pandey, B; Schwebke, JR; Shaw, J; Van Gerwen, OT | 1 |
| Asiago-Reddy, EA; Coyne, JL; Kufel, WD; Parsels, KA; Sanyal, S | 1 |
| Ansari, MA; Jahangir, S; Khan, KM; Saad, SM; Salar, U; Saleem, F; Taskın-Tok, T; Taslimi, P | 1 |
| Muzny, CA; Van Gerwen, OT | 1 |
| Legendre, D; Muzny, CA; Van Gerwen, OT | 1 |
| McNeil, CJ; Muzny, CA; Williamson, JC | 1 |
| Aguila, LKT; Cichewicz, RH; Kim, CM; Wood, GE | 1 |
| Kissinger, PJ; Muzny, CA | 1 |
| Boyd, P; Dallal Bashi, YH; Karl Malcolm, R; McCoy, CF; Zhao, X | 1 |
12 review(s) available for secnidazole and metronidazole
| Article | Year |
|---|---|
Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases.
Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Communicable Diseases; Humans; Nitroimidazoles; Parasitic Diseases | 2017 |
Anti-
Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Drug Delivery Systems; Drug Discovery; Drug Therapy, Combination; Gastrointestinal Tract; Giardia; Giardiasis; Humans; Nitroimidazoles | 2020 |
Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antiprotozoal Agents; Drug Development; Humans; Hypoglycemic Agents; Metronidazole | 2021 |
Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis.
Topics: Absorption; Clinical Trials as Topic; Drug Interactions; Female; Humans; Male; Metronidazole; Protozoan Infections; Tissue Distribution; Vaginosis, Bacterial | 1996 |
Efficacy of 5-nitroimidazoles for the treatment of giardiasis: a systematic review of randomized controlled trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Giardiasis; Humans; Infant; Infant, Newborn; Male; Metronidazole; Middle Aged; Randomized Controlled Trials as Topic; Tinidazole; Treatment Outcome; Young Adult | 2014 |
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) associated with pristinamycin, secnidazole, and nefopam, with a review of the literature.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antiprotozoal Agents; Drug Eruptions; Exanthema; Female; Humans; Intertrigo; Male; Metronidazole; Middle Aged; Nefopam; Pristinamycin | 2018 |
Efficacy and safety of single dose of oral secnidazole 2 g in treatment of bacterial vaginosis: A systematic review and meta-analysis.
Topics: Administration, Oral; Antiprotozoal Agents; Female; Humans; Metronidazole; Randomized Controlled Trials as Topic; Vaginosis, Bacterial | 2019 |
Characterization and Treatment of Recurrent Bacterial Vaginosis.
Topics: Anti-Bacterial Agents; Antiprotozoal Agents; Clindamycin; Female; Humans; Metronidazole; Recurrence; Treatment Outcome; Vaginosis, Bacterial | 2019 |
Noncandidal vaginitis: a comprehensive approach to diagnosis and management.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Infective Agents; Anti-Inflammatory Agents; Atrophic Vaginitis; Candidiasis, Vulvovaginal; Clindamycin; Dehydroepiandrosterone; Diagnosis, Differential; Estrogen Replacement Therapy; Estrogens; Female; Humans; Hydrocortisone; Inflammation; Lichen Planus; Metronidazole; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Pemphigus; Tamoxifen; Tinidazole; Trichomonas Vaginitis; Vaginitis; Vaginosis, Bacterial | 2020 |
Secnidazole for treatment of bacterial vaginosis: a systematic review.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Humans; Metronidazole; Middle Aged; Recurrence; Treatment Outcome; Vaginosis, Bacterial | 2019 |
Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions.
Topics: Alcohols; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cephalosporins; Doxycycline; Drug Interactions; Erythromycin; Fluoroquinolones; Metronidazole; Penicillins; Tetracycline | 2020 |
Secnidazole for Trichomoniasis in Women and Men.
Topics: Female; Humans; Male; Metronidazole; Observational Studies as Topic; Randomized Controlled Trials as Topic; Trichomonas Infections; Trichomonas vaginalis; Vaginosis, Bacterial | 2022 |
34 trial(s) available for secnidazole and metronidazole
| Article | Year |
|---|---|
Comparison between the efficacy of a single dose of secnidazole with a 5-day course of tetracycline and clioquinol in the treatment of acute intestinal amoebiasis.
Topics: Acute Disease; Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Clioquinol; Drug Therapy, Combination; Dysentery, Amebic; Female; Humans; Hydroxyquinolines; Male; Metronidazole; Middle Aged; Random Allocation; Tetracycline; Time Factors | 1985 |
Ornidazole and secnidazole in the treatment of symptomatic intestinal amoebiasis in childhood.
Topics: Administration, Oral; Child, Preschool; Drug Administration Schedule; Dysentery, Amebic; Female; Humans; Infant; Male; Metronidazole; Ornidazole | 1994 |
Trichomoniasis in non-gonococcic urethritis among male patients.
Topics: Adult; Animals; Follow-Up Studies; Humans; Male; Metronidazole; Middle Aged; Ornidazole; Trichomonas Infections; Trichomonas vaginalis; Urethritis | 1994 |
[Comparative study for the evaluation of the efficacy and safety of metronidazole and secnidazole in the treatment of vaginal trichomoniasis].
Topics: Animals; Antiprotozoal Agents; Antitrichomonal Agents; Female; Humans; Metronidazole; Trichomonas vaginalis; Trichomonas Vaginitis | 1997 |
Randomized double-blind trial of metronidazole versus secnidazole in amebic liver abscess.
Topics: Adult; Antiprotozoal Agents; Double-Blind Method; Female; Humans; Liver Abscess, Amebic; Male; Metronidazole; Ultrasonography | 1998 |
[Itraconazole and secnidazole capsules vs. vaginal ovules of fluocinolone acetonide, nystatin and metronidazole in the symptomatic treatment of vaginitis].
Topics: Antiprotozoal Agents; Antitrichomonal Agents; Female; Fluocinolone Acetonide; Humans; Itraconazole; Metronidazole; Nystatin; Vaginitis | 1998 |
Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Developing Countries; Drug Therapy, Combination; Duodenal Ulcer; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lansoprazole; Male; Metronidazole; Middle Aged; Omeprazole; Pefloxacin; Proton Pump Inhibitors | 1998 |
Treatment of bacterial vaginosis with oral or vaginal ornidazole, secnidazole and metronidazole.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Infective Agents; Drug Therapy, Combination; Female; Humans; Metronidazole; Ornidazole; Recurrence; Treatment Outcome; Vaginosis, Bacterial | 1998 |
Secnidazole response in amoebiasis and giardiasis.
Topics: Adolescent; Adult; Aged; Amebiasis; Antiprotozoal Agents; Feces; Female; Giardiasis; Humans; Male; Metronidazole; Middle Aged; Pakistan; Patient Compliance; Treatment Outcome | 1999 |
Clinical trial with Secnidazole in a single dose in Venezuelan children infected by Giardia intestinalis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Child; Child, Preschool; Data Interpretation, Statistical; Female; Giardiasis; Humans; Male; Metronidazole; Poverty Areas; Risk Factors; Socioeconomic Factors; Venezuela | 2000 |
Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole.
Topics: Adolescent; Adult; Animals; Antiprotozoal Agents; Child; Child, Preschool; Diarrhea; Dientamoeba; Dientamoebiasis; Feces; Giardia lamblia; Giardiasis; Humans; Metronidazole; Middle Aged | 2003 |
A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis.
Topics: Adolescent; Antiprotozoal Agents; Child; Child, Preschool; Feces; Female; Giardiasis; Humans; Male; Mebendazole; Metronidazole; Treatment Outcome | 2003 |
Ciprofloxacin-tinidazole combination, fluconazole- azithromicin-secnidazole-kit and doxycycline- metronidazole combination therapy in syndromic management of pelvic inflammatory disease: a prospective randomized controlled trial.
Topics: Adolescent; Adult; Azithromycin; Ciprofloxacin; Doxycycline; Drug Therapy, Combination; Female; Fluconazole; Humans; Metronidazole; Pelvic Inflammatory Disease; Prospective Studies; Tinidazole | 2003 |
Low-dose secnidazole in the treatment of bacterial vaginosis.
Topics: Adult; Antiprotozoal Agents; Female; Humans; Metronidazole; Middle Aged; Papanicolaou Test; Treatment Outcome; Vaginal Smears; Vaginosis, Bacterial | 2005 |
Comparative efficacy of two regimens in syndromic management of lower genital infections.
Topics: Administration, Intravaginal; Adult; Anti-Infective Agents, Local; Azithromycin; Clotrimazole; Drug Therapy, Combination; Female; Fluconazole; Humans; Metronidazole; Pruritus; Vaginitis | 2006 |
Short-term therapy for mixed vaginal infections.
Topics: Administration, Oral; Antifungal Agents; Antiprotozoal Agents; Antitrichomonal Agents; Candidiasis, Vulvovaginal; Drug Therapy, Combination; Female; Fluconazole; Humans; Itraconazole; Metronidazole; Patient Compliance; Tinidazole; Treatment Outcome; Trichomonas Vaginitis; Vaginosis, Bacterial | 2006 |
Evaluation of the bioequivalence and pharmacokinetics of two formulations of secnidazole after single oral administration in healthy volunteers.
Topics: Adult; Antiprotozoal Agents; Area Under Curve; Biological Availability; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Humans; Male; Metronidazole; Tablets; Therapeutic Equivalency | 2007 |
Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study.
Topics: Albendazole; Animals; Anthelmintics; Anthropometry; Antiprotozoal Agents; Bangladesh; Breast Feeding; Double-Blind Method; Female; Giardiasis; Growth; Growth Disorders; Humans; Infant; Intestinal Mucosa; Longitudinal Studies; Male; Metronidazole; Mothers | 2009 |
[Efficacy of 5-nitroimidazole derivatives in treatment of bacterial vaginosis].
Topics: Administration, Intravaginal; Administration, Oral; Adult; Delayed-Action Preparations; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Metronidazole; Nitroimidazoles; Ornidazole; Prospective Studies; Tablets; Tinidazole; Treatment Outcome; Vaginosis, Bacterial; Young Adult | 2008 |
Treatment of bacterial vaginosis: a multicenter, double-blind, double-dummy, randomised phase III study comparing secnidazole and metronidazole.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Chi-Square Distribution; Double-Blind Method; Female; Humans; Metronidazole; Middle Aged; Prospective Studies; Treatment Outcome; Vaginosis, Bacterial | 2010 |
Efficacy of the Mentha crispa in the treatment of women with Trichomonas vaginalis infection.
Topics: Adult; Antitrichomonal Agents; Double-Blind Method; Dyspareunia; Dysuria; Female; Humans; Male; Mentha; Metronidazole; Middle Aged; Nausea; Pelvic Pain; Phytotherapy; Plant Extracts; Pruritus; Statistics, Nonparametric; Taste Disorders; Trichomonas vaginalis; Trichomonas Vaginitis; Vaginal Discharge; Young Adult | 2012 |
Prevalence, hematology, and treatment of balantidiasis among donkeys in and around Lahore, Pakistan.
Topics: Animals; Antiprotozoal Agents; Balantidiasis; Equidae; Female; Male; Metronidazole; Nigella sativa; Pakistan; Plant Extracts; Prevalence | 2013 |
Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from 2 to 5 years of age in Bangladesh.
Topics: Administration, Oral; Albendazole; Anthelmintics; Antibodies, Bacterial; Bangladesh; Child, Preschool; Double-Blind Method; Female; Humans; Male; Metronidazole; Pilot Projects; Polysaccharides, Bacterial; T-Lymphocytes; Typhoid Fever; Typhoid-Paratyphoid Vaccines | 2014 |
[Estimation of efficiency of anti-helicobacter therapy in patients with a chronic pancreatitis combined with an erosive gastropathy].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Middle Aged; Pancreatitis, Chronic; Pantoprazole; Synbiotics | 2014 |
Lack of a Pharmacokinetic Interaction Between SYM-1219 Granules Containing 2 Grams of Secnidazole and a Combined Oral Contraceptive in a Phase 1, Randomized, Open-Label Study in Healthy Female Volunteers.
Topics: Adult; Contraceptives, Oral, Combined; Drug Interactions; Ethinyl Estradiol; Female; Humans; Metronidazole; Middle Aged; Vaginosis, Bacterial | 2017 |
Secnidazole Treatment of Bacterial Vaginosis: A Randomized Controlled Trial.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Black People; Double-Blind Method; Female; Humans; Metronidazole; Middle Aged; Placebos; Treatment Outcome; Vaginosis, Bacterial; White People | 2017 |
A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Candidiasis, Vulvovaginal; Diarrhea; Double-Blind Method; Female; Headache; Humans; Metronidazole; Middle Aged; Nausea; Treatment Outcome; Vaginal Discharge; Vaginosis, Bacterial; Young Adult | 2017 |
Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals.
Topics: Adult; Antiprotozoal Agents; Cross-Over Studies; Electrocardiography; Female; Heart Rate; Humans; Long QT Syndrome; Metronidazole; Middle Aged; Vaginosis, Bacterial; Young Adult | 2018 |
Two Phase 1, Open-Label, Single-Dose, Randomized, Crossover Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered Granules of Secnidazole (2 g) in Healthy Female Volunteers Under Different Administration Conditions.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Drug Compounding; Fasting; Female; Food; Food-Drug Interactions; Healthy Volunteers; Humans; Metronidazole; Middle Aged; Therapeutic Equivalency; Vaginosis, Bacterial; Young Adult | 2018 |
Treatment for Symptomatic Bacterial Vaginosis: ARandomized Controlled Trial.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anti-Bacterial Agents; Antiprotozoal Agents; Clindamycin; Double-Blind Method; Female; Humans; Metronidazole; Vaginal Creams, Foams, and Jellies; Vaginosis, Bacterial | 2017 |
A Phase 3, Multicenter, Prospective, Open-Label Study to Evaluate the Safety of a Single Dose of Secnidazole 2 g for the Treatment of Women and Postmenarchal Adolescent Girls with Bacterial Vaginosis.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Female; Humans; Metronidazole; Prospective Studies; Treatment Outcome; United States; Vaginal Discharge; Vaginosis, Bacterial; Young Adult | 2018 |
A prophylactic protocol to stimulate the immune response also controls infectious disease and, consequently, minimizes diarrhea in newborn heifers.
Topics: Animals; Animals, Newborn; Antioxidants; Blood Glucose; Cattle; Cattle Diseases; Cholesterol; Diarrhea; Feces; Female; Giardia lamblia; Giardiasis; Hematocrit; Lipid Peroxidation; Malondialdehyde; Metronidazole; Random Allocation; Serum Albumin; Sodium Selenite; Triglycerides; Urea; Vitamin A; Vitamin E | 2018 |
An Integrated Efficacy and Safety Analysis of Single-Dose Secnidazole 2 g in the Treatment of Bacterial Vaginosis.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Metronidazole; Middle Aged; Treatment Outcome; Vaginosis, Bacterial; Young Adult | 2020 |
Efficacy and Safety of Single Oral Dosing of Secnidazole for Trichomoniasis in Women: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Delayed-Treatment Study.
Topics: Double-Blind Method; Female; Humans; Metronidazole; Treatment Outcome; Trichomonas Infections; Vaginosis, Bacterial | 2021 |
71 other study(ies) available for secnidazole and metronidazole
| Article | Year |
|---|---|
Lowering of 5-nitroimidazole's mutagenicity: towards optimal antiparasitic pharmacophore.
Topics: Animals; Antiparasitic Agents; Humans; Imidazoles; Inhibitory Concentration 50; Monocytes; Mutagenicity Tests; Nitroimidazoles; Salmonella; Structure-Activity Relationship; Trichomonas vaginalis | 2009 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Secnidazole. A 5-nitroimidazole derivative with a long half-life.
Topics: Adolescent; Adult; Female; Half-Life; Humans; Kinetics; Male; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Trichomonas Infections; Trichomonas vaginalis; Urogenital System | 1978 |
Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture.
Topics: Blotting, Northern; Cells, Cultured; Clotrimazole; Cytochrome P-450 Enzyme System; Fluconazole; Humans; Imidazoles; Kinetics; Liver; Metronidazole; Miconazole; Microsomes, Liver; Mixed Function Oxygenases; RNA; RNA, Messenger | 1992 |
A new screening assay for antigiardial compounds: effects of various drugs on the adherence of Giardia duodenalis to Caco2 cells.
Topics: Animals; Antiprotozoal Agents; Cell Adhesion; Cell Line; Furazolidone; Giardia; Mefloquine; Metronidazole; Quinacrine | 1992 |
Efficacy of a single dose of secnidazole in the treatment of acute and chronic amoebiasis.
Topics: Acute Disease; Administration, Oral; Adult; Animals; Chronic Disease; Drug Evaluation; Dysentery, Amebic; Entamoeba histolytica; Female; Humans; Male; Metronidazole | 1988 |
Nitroimidazoles in the treatment of trichomoniasis, giardiasis, and amebiasis.
Topics: Amebiasis; Animals; Chemical Phenomena; Chemistry; Cricetinae; Female; Giardiasis; Humans; Metronidazole; Mice; Nitroimidazoles; Ornidazole; Rats; Structure-Activity Relationship; Tinidazole; Trichomonas Infections; Trichomonas Vaginitis | 1984 |
Electron-capture gas chromatographic assays of 5-nitroimidazole class of antimicrobials in blood.
Topics: Antitrichomonal Agents; Chromatography, Gas; Humans; Metronidazole; Nitroimidazoles; Ornidazole; Tinidazole | 1984 |
[Study of serum concentrations and urinary excretion of secnidazole after oral administration in man. Comparison with tinidazole].
Topics: Administration, Oral; Adult; Antitrichomonal Agents; Female; Humans; Kinetics; Male; Metronidazole; Tinidazole | 1980 |
Effect of single dose of secnidazole in treatment of intestinal amoebiasis.
Topics: Abdominal Pain; Adult; Amebicides; Animals; Carrier State; Case-Control Studies; Defecation; Dysentery, Amebic; Entamoeba histolytica; Feces; Gastrointestinal Hemorrhage; Humans; Metronidazole | 1995 |
Efficacy of secnidazole in the treatment of intestinal amoebiasis.
Topics: Adolescent; Adult; Aged; Dysentery, Amebic; Female; Humans; Male; Metronidazole; Middle Aged; Treatment Outcome | 1994 |
Secnidazole concentrations in plasma and crevicular fluid after a single oral dose.
Topics: Absorption; Administration, Oral; Adult; Chromatography, High Pressure Liquid; Gingival Crevicular Fluid; Half-Life; Humans; Metronidazole; Time Factors | 1993 |
Single-dose secnidazole versus 10-day metronidazole therapy of giardiasis in Iranian children.
Topics: Adolescent; Antiprotozoal Agents; Child; Child, Preschool; Drug Administration Schedule; Female; Giardiasis; Humans; Iran; Male; Metronidazole; Treatment Outcome | 1996 |
Secnidazole in the treatment of giardiasis.
Topics: Adult; Antiprotozoal Agents; Feces; Female; Follow-Up Studies; Giardiasis; Humans; Male; Metronidazole; Middle Aged | 1995 |
Rapid and selective analysis of secnidazole in human plasma using high-performance liquid chromatography with ultraviolet detection.
Topics: Antiprotozoal Agents; Chromatography, High Pressure Liquid; Humans; Metronidazole; Reproducibility of Results; Sensitivity and Specificity | 1997 |
Secnidazole vs. paromomycin: comparative antiprotozoan treatment in captive primates.
Topics: Animals; Antiprotozoal Agents; Cercopithecidae; Entamoeba; Entamoebiasis; Hominidae; Metronidazole; Paromomycin; Primate Diseases; Primates; Protozoan Infections, Animal | 1998 |
Fixed drug eruption due to metronidazole and tinidazole without cross-sensitivity to secnidazole.
Topics: Adult; Antiprotozoal Agents; Cross Reactions; Drug Eruptions; Giardiasis; Humans; Male; Metronidazole; Tinidazole | 1998 |
Oral pharmacological treatments for parasitic diseases of rainbow trout oncorhynchus mykiss. III. Ichthyobodo necator.
Topics: Administration, Oral; Animal Feed; Animals; Anti-Infective Agents; Antiparasitic Agents; Benzimidazoles; Fish Diseases; Metronidazole; Oncorhynchus mykiss; Protozoan Infections; Protozoan Infections, Animal; Skin Diseases, Parasitic; Triclabendazole | 1998 |
Mechanism of interaction of in situ produced nitroimidazole reduction derivatives with DNA using electrochemical DNA biosensor.
Topics: Biosensing Techniques; DNA; DNA Damage; Electrodes; Metronidazole; Models, Chemical; Nitroimidazoles; Oxidation-Reduction; Tinidazole | 1999 |
Haemoglobin concentrations and infection by Giardia intestinalis in children: effect of treatment with secnidazole.
Topics: Anemia; Antiprotozoal Agents; Case-Control Studies; Child; Child, Preschool; Female; Giardiasis; Hemoglobins; Humans; Male; Metronidazole; Treatment Outcome | 1999 |
Determination of secnidazole in urine by adsorptive stripping voltammetry.
Topics: Antiprotozoal Agents; Electrochemistry; Electrodes; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Mercury; Metronidazole; Oxidation-Reduction | 2000 |
Spectrophotometric and HPLC determination of secnidazole in pharmaceutical tablets.
Topics: Antiprotozoal Agents; Chromatography, High Pressure Liquid; Colorimetry; Metronidazole; Nitroprusside; Schiff Bases; Solutions; Spectrophotometry, Ultraviolet; Tablets | 2000 |
Spectrophotometric determination of metronidazole and secnidazole in pharmaceutical preparations.
Topics: Metronidazole; Spectrophotometry, Ultraviolet | 2004 |
ICH guidance in practice: establishment of inherent stability of secnidazole and development of a validated stability-indicating high-performance liquid chromatographic assay method.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Guidelines as Topic; International Cooperation; Metronidazole | 2004 |
Determination of secnidazole in human plasma by high-performance liquid chromatography with UV detection and its application to the bioequivalence studies.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antiprotozoal Agents; Area Under Curve; Biological Availability; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Male; Metronidazole; Plasma; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Therapeutic Equivalency; Tinidazole | 2007 |
Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis.
Topics: Absorbable Implants; Chemistry, Pharmaceutical; Doxycycline; Drug Carriers; Drug Combinations; Drug Evaluation, Preclinical; Drug Implants; Drug Resistance, Bacterial; Fusobacteria; Humans; Lactic Acid; Metronidazole; Peptostreptococcus; Periodontitis; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Porphyromonas; Prevotella; Streptococcus | 2008 |
Formulation and evaluation of secnidazole or doxycycline dento-oral gels.
Topics: Administration, Oral; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Doxycycline; Gels; Humans; Metronidazole; Microbial Sensitivity Tests; Periodontitis; Solubility; Viscosity | 2008 |
Molecular structure and vibrational spectroscopic investigation of secnidazole using density functional theory.
Topics: Antiprotozoal Agents; Metronidazole; Molecular Structure; Quantum Theory; Spectrum Analysis; Spectrum Analysis, Raman; Thermodynamics; Vibration | 2009 |
Antibody response in children infected with Giardia intestinalis before and after treatment with Secnidazole.
Topics: Animals; Antibodies, Protozoan; Antibody Formation; Antiprotozoal Agents; Child; Child, Preschool; Diarrhea; Enzyme-Linked Immunosorbent Assay; Female; Giardia lamblia; Giardiasis; Humans; Immunoglobulin A; Immunoglobulin G; Male; Metronidazole; Suburban Population; Treatment Outcome; Venezuela | 2009 |
Formulation and in vitro evaluation of in situ gels containing secnidazole for vaginitis.
Topics: Adhesiveness; Antiprotozoal Agents; Carboxymethylcellulose Sodium; Chemical Phenomena; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dosage Forms; Drug Delivery Systems; Female; Humans; Metronidazole; Polysaccharides, Bacterial; Trichomonas Vaginitis; Vaginal Creams, Foams, and Jellies | 2009 |
In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis.
Topics: Actinobacteria; Antiprotozoal Agents; Female; Humans; Metronidazole; Microbial Sensitivity Tests; Vaginosis, Bacterial | 2010 |
[In vitro effect of secnidazole benzoate on Trichomonas vaginalis].
Topics: Animals; Antitrichomonal Agents; Benzoates; In Vitro Techniques; Metronidazole; Parasitic Sensitivity Tests; Trichomonas vaginalis | 2009 |
Secnidazole-induced acute pancreatitis: a new side-effect for an old drug?
Topics: Acute Disease; Anti-Infective Agents; Female; Humans; Metronidazole; Pancreatitis; Young Adult | 2010 |
Could giardiasis be a risk factor for low zinc status in schoolchildren from northwestern Mexico? A cross-sectional study with longitudinal follow-up.
Topics: Antiprotozoal Agents; Child; Cross-Sectional Studies; Deficiency Diseases; Female; Follow-Up Studies; Giardiasis; Humans; Male; Metronidazole; Mexico; Nutritional Status; Schools; Socioeconomic Factors; Surveys and Questionnaires; Zinc | 2010 |
A molecularly imprinted monolith for the fast chiral separation of antiparasitic drugs by pressurized CEC.
Topics: Amebicides; Antiprotozoal Agents; Buffers; Capillary Electrochromatography; Cross-Linking Reagents; Hydrogen-Ion Concentration; Metronidazole; Microscopy, Electron, Scanning; Molecular Imprinting; Molecular Structure; Ornidazole; Polymers; Porosity; Solvents; Stereoisomerism | 2010 |
Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.
Topics: Adult; Antiprotozoal Agents; Biopsy; Cross Reactions; Drug Eruptions; Glucocorticoids; Humans; Male; Metronidazole; Nitroimidazoles; Ornidazole; Pregnadienetriols; Treatment Outcome | 2010 |
Hospitalization of Cuban children for giardiasis: a retrospective study in a paediatric hospital in Havana.
Topics: Abdominal Pain; Antiprotozoal Agents; Child; Child, Preschool; Cuba; Diarrhea; Female; Giardiasis; Hospitalization; Hospitals, Pediatric; Humans; Infant; Length of Stay; Male; Medical Records; Metronidazole; Quinacrine; Retrospective Studies; Tinidazole; Treatment Outcome; Vomiting | 2011 |
Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cinnamates; Humans; Inhibitory Concentration 50; Metronidazole; Microbial Sensitivity Tests; Molecular Dynamics Simulation | 2011 |
Secnidazole for the treatment of giardiasis in naturally infected cats.
Topics: Animals; Antiprotozoal Agents; Blood Chemical Analysis; Brazil; Cat Diseases; Cats; Feces; Female; Giardia lamblia; Giardiasis; Humans; Metronidazole; Parasite Load; Treatment Outcome | 2011 |
Extractional spectrophotometric analysis of metronidazole, tinidazole, ornidazole and secnidazole bases through acid-dye complexation using bromothymol blue dye.
Topics: Acids; Bromthymol Blue; Chemistry, Pharmaceutical; Coloring Agents; Hydrogen-Ion Concentration; Injections; Metronidazole; Ornidazole; Solutions; Spectrophotometry, Ultraviolet; Tablets; Temperature; Time Factors; Tinidazole | 2012 |
Design and gamma scintigraphic evaluation of colon specific pectin-EC pellets of secnidazole prepared by powder layering technology.
Topics: Animals; Antiprotozoal Agents; Calorimetry, Differential Scanning; Cellulose; Chemistry, Pharmaceutical; Colon; Drug Compounding; Drug Delivery Systems; Excipients; Gamma Rays; Male; Metronidazole; Microscopy, Electron, Scanning; Particle Size; Pectins; Powders; Rabbits; Radionuclide Imaging; Spectroscopy, Fourier Transform Infrared; Technetium Tc 99m Pentetate | 2011 |
Influence of polymers/excipients on development of agglomerated crystals of secnidazole by crystallo-co-agglomeration technique to improve processability.
Topics: Antiprotozoal Agents; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Excipients; Metronidazole; Particle Size; Polymers | 2013 |
Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs.
Topics: Antitrichomonal Agents; Clotrimazole; Fluorometry; High-Throughput Screening Assays; Metronidazole; Oxazines; Parasitic Sensitivity Tests; Sensitivity and Specificity; Trichomonas vaginalis; Xanthenes | 2012 |
Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Anti-Bacterial Agents; Bacillus subtilis; Drug Design; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Metronidazole; Microbial Sensitivity Tests; Molecular Docking Simulation; Pseudomonas aeruginosa; Schiff Bases; Staphylococcus aureus; Structure-Activity Relationship | 2013 |
Treatment failure in patients with chronic Blastocystis infection.
Topics: Adolescent; Adult; Antiprotozoal Agents; Blastocystis; Blastocystis Infections; Child; Chronic Disease; Cohort Studies; DNA, Protozoan; Drug Therapy, Combination; Feces; Female; Furazolidone; Genotype; Humans; Male; Metronidazole; Middle Aged; Nitro Compounds; Sequence Analysis, DNA; Thiazoles; Treatment Failure; Young Adult | 2014 |
Enantioselective HPLC determination and pharmacokinetic study of secnidazole enantiomers in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Limit of Detection; Linear Models; Male; Metronidazole; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Stereoisomerism | 2014 |
Molecularly imprinted solid phase extraction of fluconazole from pharmaceutical formulations.
Topics: Acetonitriles; Fluconazole; Imidazoles; Methacrylates; Metronidazole; Miconazole; Molecular Imprinting; Polymers; Solid Phase Extraction | 2015 |
Coinfection with
Topics: Adult; Animals; Anthelmintics; Anti-HIV Agents; Antiprotozoal Agents; Coinfection; Diarrhea; Giardia lamblia; Giardiasis; HIV; HIV Infections; Humans; Hymenolepiasis; Hymenolepis diminuta; Hymenolepis nana; Male; Metronidazole; Nitro Compounds; Praziquantel; Thiazoles; Treatment Outcome; Weight Loss | 2017 |
Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Controlled Clinical Trials as Topic; Double-Blind Method; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Metronidazole; Middle Aged; Multicenter Studies as Topic; Trichomonas vaginalis; Trichomonas Vaginitis; United States; Vaginosis, Bacterial; Young Adult | 2018 |
Secnidazole (Solosec) for bacterial vaginosis.
Topics: Anti-Bacterial Agents; Drug Interactions; Female; Humans; Metronidazole; Treatment Outcome; Vaginosis, Bacterial | 2018 |
Secnidazole for control of giardiasis in dairy calves.
Topics: Animals; Animals, Newborn; Antiprotozoal Agents; Cattle; Cattle Diseases; Feces; Female; Giardia lamblia; Giardiasis; Metronidazole | 2018 |
Topics: Animals; Biological Transport, Active; Cell Line, Tumor; Drug Stability; Female; Metronidazole; Mice; Organotechnetium Compounds; Radiopharmaceuticals; Sarcoma 180; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tumor Hypoxia | 2018 |
New Drugs 2018, part 3.
Topics: Acetates; Boronic Acids; Drug Approval; Drug Combinations; Fluoroquinolones; Humans; Meropenem; Metronidazole; Nitroimidazoles; Parathyroid Hormone-Related Protein; Peptides; Prostaglandins F, Synthetic; Quinazolines; Thienamycins; United States; United States Food and Drug Administration | 2018 |
Repositioning secnidazole as a novel virulence factors attenuating agent in Pseudomonas aeruginosa.
Topics: Animals; Anti-Infective Agents; Disease Models, Animal; Drug Repositioning; Gene Expression Profiling; Metronidazole; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Real-Time Polymerase Chain Reaction; Survival Analysis; Virulence Factors | 2019 |
Treatment of refractory paediatric giardiasis using secnidazole plus albendazole: a case series.
Topics: Adolescent; Albendazole; Antiprotozoal Agents; Child; Child, Preschool; Drug Combinations; Female; Giardia lamblia; Giardiasis; Humans; Male; Metronidazole; Retrospective Studies | 2018 |
Secnidazole (Solosec) for Bacterial Vaginosis.
Topics: Adult; Anti-Bacterial Agents; Clinical Trials as Topic; Female; Humans; Metronidazole; Treatment Outcome; Vaginosis, Bacterial | 2019 |
Successful use of secnidazole to manage a giardiosis outbreak in a shelter.
Topics: Animals; Antigens, Protozoan; Antiprotozoal Agents; Dog Diseases; Dogs; Genotype; Giardia lamblia; Giardiasis; Housing, Animal; Metronidazole; Reagent Kits, Diagnostic | 2019 |
Giardiasis: report of a case refractory to treatment.
Topics: Adult; Albendazole; Antiprotozoal Agents; Furazolidone; Giardia lamblia; Giardiasis; Humans; Male; Metronidazole; Nitro Compounds; Nitroimidazoles; Thiazoles; Tinidazole; Treatment Failure | 2019 |
5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study.
Topics: Adult; Aged; Antiprotozoal Agents; Cuba; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Feces; Female; Giardia lamblia; Giardiasis; Humans; Male; Mebendazole; Metronidazole; Middle Aged; Nitroimidazoles; Prospective Studies; Quinacrine; Treatment Outcome; Young Adult | 2020 |
Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies.
Topics: Antiprotozoal Agents; Carbamates; Giardia lamblia; Giardiasis; Metronidazole; Trichomonas Infections; Trichomonas vaginalis | 2020 |
Transition Metal Chelation Augments the Half-life of Secnidazole: Molecular Docking and Fluorescence Spectroscopic Approaches.
Topics: Chelating Agents; Coordination Complexes; Fluorescence; Half-Life; Metronidazole; Molecular Docking Simulation; Protein Binding; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics | 2020 |
HPLC Determination of Imidazoles with Variant Anti-Infective Activity in Their Dosage Forms and Human Plasma.
Topics: Albendazole; Anti-Infective Agents; Calibration; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dosage Forms; Fenbendazole; Humans; Hydrogen-Ion Concentration; Imidazoles; Metronidazole; Omeprazole; Patient Safety; Reproducibility of Results; Solvents; Temperature; Ultraviolet Rays; United States; United States Food and Drug Administration | 2020 |
Thermosensitive hydrogels for vaginal delivery of secnidazole as an approach to overcome the systemic side-effects of oral preparations.
Topics: Delivery, Obstetric; Drug Delivery Systems; Female; Humans; Hydrogels; Metronidazole; Poloxamer; Pregnancy; Temperature | 2021 |
The immunomodulatory activity of secnidazole-nitazoxanide in a murine cryptosporidiosis model.
Topics: Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Cytokines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Ileum; Immunocompromised Host; Immunomodulation; Male; Metronidazole; Mice; Nitro Compounds; Parasite Load; Thiazoles | 2021 |
Successful treatment with secnidazole for trichomoniasis in the setting of metronidazole hypersensitivity.
Topics: Drug Hypersensitivity; Female; Humans; Metronidazole; Treatment Outcome; Trichomonas Infections; Trichomonas vaginalis; Trichomonas Vaginitis | 2021 |
Biology-oriented drug synthesis and evaluation of secnidazole esters as novel enzyme ınhibitors.
Topics: Animals; Carbonic Anhydrase Inhibitors; Cholinesterase Inhibitors; Electrophorus; Esters; Glycoside Hydrolase Inhibitors; Horses; Humans; Inhibitory Concentration 50; Ligands; Metronidazole; Molecular Docking Simulation; Structure-Activity Relationship | 2022 |
Secnidazole: a treatment for trichomoniasis in adolescents and adults.
Topics: Adolescent; Adult; Female; Humans; Metronidazole; Nitroimidazoles; Trichomonas Infections; Trichomonas vaginalis; Trichomonas Vaginitis; United States; Vaginosis, Bacterial | 2022 |
Successful Treatment of Persistent 5-Nitroimidazole-Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid.
Topics: Female; Humans; Metronidazole; Tinidazole; Trichomonas Infections; Trichomonas Vaginitis | 2023 |
Topics: Anti-Bacterial Agents; Doxycycline; Drug Resistance, Bacterial; Female; Humans; Male; Metronidazole; Mycoplasma genitalium; Mycoplasma Infections; Nitroimidazoles; Tinidazole | 2023 |
Where Do Tinidazole and Secnidazole Fit in With the Treatment of Trichomoniasis?
Topics: Female; Humans; Metronidazole; Nitroimidazoles; Tinidazole; Trichomonas Infections; Trichomonas Vaginitis | 2023 |
Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis.
Topics: Administration, Intravaginal; Anti-Bacterial Agents; Contraceptive Devices, Female; Delayed-Action Preparations; Female; Humans; Metronidazole; Ornidazole; Silicone Elastomers; Tinidazole; Vaginosis, Bacterial | 2023 |