sdz 205-557 has been researched along with 4-aminobenzoic acid in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 31 (81.58) | 18.2507 |
| 2000's | 6 (15.79) | 29.6817 |
| 2010's | 1 (2.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grosset, A; Lorrain, J; O'Connor, SE | 1 |
| Buchheit, KH; Gamse, R; Pfannkuche, HJ | 2 |
| Coleman, J; Rhodes, KF | 1 |
| Grider, JR; Kuemmerle, JF; Makhlouf, GM; Martin, DC; Murthy, KS | 1 |
| Franks, CM; Hardcastle, J; Hardcastle, PT; Sanger, GJ | 1 |
| Bingham, S; Gaster, L; King, BF; Rushant, B; Sanger, GJ; Smith, MI | 1 |
| Buchheit, KH; Buhl, T | 1 |
| Ansanay, H; Bockaert, J; Dumuis, A; Miller, R; Rondé, P | 1 |
| Cheng, CH; Costall, B; Kelly, ME; Naylor, RJ | 1 |
| Bornstein, JC; Furness, JB; Yuan, SY | 1 |
| Andrade, R; Holt, IL; Torres, GE | 1 |
| Costall, B; Naylor, RJ | 1 |
| Bley, K; Bonhaus, DW; Clark, RD; Eglen, RM; Hegde, SS; Johnson, LG; Leung, E; Wong, EH | 1 |
| Costall, B; Naylor, RJ; Tuladhar, BR | 1 |
| Sanger, GJ; Wardle, KA | 1 |
| Akkermans, LM; Briejer, MR; Lefebvre, RA; Meulemans, AL; Schuurkes, JA | 1 |
| Flynn, DL; Goldstin, B; Gullikson, GW; Moormann, AE; Yang, DC | 1 |
| Alvarez, R; Eglen, RM; Johnson, LG; Leung, E; Wong, EH | 1 |
| Bartolini, A; Casamenti, F; Galeotti, N; Ghelardini, C; Gualtieri, F; Malmberg-Aiello, P; Pepeu, G | 1 |
| Ito, H; Kamato, T; Miyata, K; Nagakura, Y; Nishida, A; Yamano, M | 1 |
| Matsuyama, S; Nei, K; Sakiyama, H; Tanaka, C | 1 |
| Banner, SE; Bywater, D; Gaster, LM; Sanger, GJ; Smith, MI | 1 |
| Amemiya, N; Hatta, S; Ohshika, H; Takemura, H | 1 |
| Kadowaki, M; Kontoh, A; Nagakura, Y; Shimomura, K; Tokita, K; Tomoi, M | 1 |
| Espejo, EF; Gil, E | 1 |
| Hillsley, K; Mawe, GM | 1 |
| Sugimoto, Y; Yamada, J; Yoshikawa, T | 1 |
| Lambert, HW; Lauder, JM | 1 |
| Adaikan, PG; Hayes, ES; Ng, SC; Ratnam, SS | 1 |
| Cunningham, KA; McMahon, LR | 1 |
| Bywater, RA; Fida, R; Lyster, DJ; Taylor, GS | 1 |
| Cai, X; Feng, J; Flores-Hernandez, J; Yan, Z | 1 |
| Debonnel, G; Lucas, G | 1 |
| Furukawa, K; Ishii, N; Nagao, K; Uchiyama, T | 1 |
| Gudelsky, GA; Nair, SG | 1 |
| Endo, T; Fukushi, E; Hamaue, N; Hirafuji, M; Kang, Y; Minami, M; Saito, M; Sato, H | 1 |
| Brookes, SJ; Dinning, P; Flack, N; Kyloh, M; Nicholas, SJ; Oliver, J; Robinson, L; Sia, TC; Spencer, NJ; Wattchow, DA | 1 |
1 review(s) available for sdz 205-557 and 4-aminobenzoic acid
| Article | Year |
|---|---|
The pharmacology of the 5-HT4 receptor.
Topics: 4-Aminobenzoic Acid; 5-Hydroxytryptophan; Animals; Anxiety; Arousal; Brain; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Mice; Neural Inhibition; Ondansetron; para-Aminobenzoates; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron | 1993 |
37 other study(ies) available for sdz 205-557 and 4-aminobenzoic acid
| Article | Year |
|---|---|
5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle.
Topics: 4-Aminobenzoic Acid; Animals; Cardiotonic Agents; Female; Heart Atria; In Vitro Techniques; Male; Papillary Muscles; para-Aminobenzoates; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Swine | 1992 |
SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum.
Topics: 4-Aminobenzoic Acid; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Radioligand Assay; Serotonin Antagonists; Tropisetron | 1992 |
SDZ 205-557, a selective antagonist at 5-HT4 receptors in the isolated guinea pig ileum.
Topics: 4-Aminobenzoic Acid; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Serotonin; Serotonin Antagonists | 1991 |
Further characterization of the putative 5-HT4 receptor mediating depolarization of the rat isolated vagus nerve.
Topics: 4-Aminobenzoic Acid; Animals; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Male; Ondansetron; para-Aminobenzoates; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Vagus Nerve | 1995 |
Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells.
Topics: 4-Aminobenzoic Acid; Cyclic AMP; Humans; Inositol 1,4,5-Trisphosphate; Intestinal Mucosa; Ketanserin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; para-Aminobenzoates; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Signal Transduction | 1995 |
Do 5-HT4 receptors mediate the intestinal secretory response to 5-HT in rat in-vivo?
Topics: 4-Aminobenzoic Acid; 5-Methoxytryptamine; Animals; Benzamides; Blood Pressure; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Colon; Dioxanes; Dose-Response Relationship, Drug; Heart Rate; Ileum; Indoles; Intestinal Mucosa; Jejunum; Male; para-Aminobenzoates; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropisetron | 1995 |
Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
Topics: 4-Aminobenzoic Acid; Animals; Atropine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Gastric Mucosa; Gastrointestinal Motility; Granisetron; Injections, Intravenous; Ketanserin; Male; Methiothepin; Methysergide; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Piperidines; Random Allocation; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach | 1995 |
Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro.
Topics: 4-Aminobenzoic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Benzamides; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ligands; Male; Metoclopramide; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; para-Aminobenzoates; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stomach; Tetrodotoxin; Tropanes; Tropisetron | 1994 |
Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclic AMP; Esophagus; In Vitro Techniques; Indoles; Muscle Relaxation; Muscle, Smooth; para-Aminobenzoates; Rats; Receptors, Serotonin; Serotonin; Signal Transduction; Sulfonamides; Time Factors | 1995 |
Actions of 5-hydroxytryptophan to inhibit and disinhibit mouse behaviour in the light/dark test.
Topics: 4-Aminobenzoic Acid; 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain Chemistry; Darkness; Indoles; Light; Male; Mice; Mice, Inbred Strains; Neostriatum; Neurotransmitter Agents; para-Aminobenzoates; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropisetron | 1994 |
Investigation of the role of 5-HT3 and 5-HT4 receptors in ascending and descending reflexes to the circular muscle of guinea-pig small intestine.
Topics: 4-Aminobenzoic Acid; Animals; Female; Guinea Pigs; In Vitro Techniques; Indoles; Intestine, Small; Male; Muscle, Smooth; para-Aminobenzoates; Receptors, Serotonin; Reflex; Serotonin Antagonists; Tropisetron | 1994 |
Antagonists of 5-HT4 receptor-mediated responses in adult hippocampal neurons.
Topics: 4-Aminobenzoic Acid; Animals; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Hippocampus; In Vitro Techniques; Indoles; Male; Membrane Potentials; para-Aminobenzoates; Rats; Receptors, Serotonin; Serotonin Antagonists; Sulfonamides | 1994 |
RS 23597-190: a potent and selective 5-HT4 receptor antagonist.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Blood Pressure; Electrophysiology; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Intestinal Mucosa; Male; Metoclopramide; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; para-Aminobenzoates; Piperidines; Radioligand Assay; Rats; Reflex; Serotonin; Serotonin Antagonists; Swine; Swine, Miniature; Vagus Nerve | 1993 |
5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea-pig isolated ileum.
Topics: 4-Aminobenzoic Acid; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Ondansetron; para-Aminobenzoates; Peristalsis; Receptors, Serotonin; Reflex; Serotonin | 1993 |
The guinea-pig distal colon--a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions.
Topics: 4-Aminobenzoic Acid; Animals; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Colon; Dose-Response Relationship, Drug; Granisetron; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; para-Aminobenzoates; Receptors, Serotonin; Serotonin | 1993 |
Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens.
Topics: 4-Aminobenzoic Acid; Animals; Cisapride; Colon; Female; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Esophagus; Imidazoles; In Vitro Techniques; Indoles; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Pyrroles; Rats; Receptors, Cell Surface; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropisetron; Tryptamines | 1993 |
The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors.
Topics: 4-Aminobenzoic Acid; Adenylyl Cyclases; Animals; Female; Guinea Pigs; Heart Rate; Hippocampus; In Vitro Techniques; Male; Mucous Membrane; Muscle, Smooth; para-Aminobenzoates; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Species Specificity; Swine; Swine, Miniature | 1993 |
Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8.
Topics: 4-Aminobenzoic Acid; Analgesics; Animals; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Indoles; Male; Mice; Organophosphorus Compounds; Pain Threshold; para-Aminobenzoates; Rats; Rats, Wistar; Receptors, Cholinergic; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 1996 |
Characterization of 5-hydroxytryptamine (5-HT) receptor subtypes influencing colonic motility in conscious dogs.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Benzimidazoles; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Colon; Dogs; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium; Injections, Intravenous; Ketanserin; Male; Methysergide; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Transducers | 1996 |
Identification of putative 5-hydroxytryptamine(4) (5-HT4) receptors in guinea pig stomach: The effect of TKS159, a novel agonist, on gastric motility and acetylcholine release.
Topics: 4-Aminobenzoic Acid; Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Guinea Pigs; Male; Muscle Contraction; para-Aminobenzoates; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach | 1996 |
Increased defaecation caused by 5-HT4 receptor activation in the mouse.
Topics: 4-Aminobenzoic Acid; 5-Hydroxytryptophan; Animals; Defecation; Dioxanes; Feces; Male; Mice; para-Aminobenzoates; Piperidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Water | 1996 |
Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.
Topics: 4-Aminobenzoic Acid; 5-Methoxytryptamine; Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Fundus; In Vitro Techniques; Male; Muscle Contraction; para-Aminobenzoates; Rats; Rats, Wistar; Serotonin; Stomach; Yohimbine | 1996 |
Combined blockade of 5-HT3- and 5-HT4-serotonin receptors inhibits colonic functions in conscious rats and mice.
Topics: 4-Aminobenzoic Acid; Animals; Colon; Dioxanes; Male; Mice; Ondansetron; para-Aminobenzoates; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin Antagonists | 1997 |
Antagonism of peripheral 5-HT4 receptors reduces visceral and cutaneous pain in mice, and induces visceral analgesia after simultaneous inactivation of 5-HT3 receptors.
Topics: 4-Aminobenzoic Acid; Analgesia; Analysis of Variance; Animals; Male; Mice; Pain; Pain Measurement; para-Aminobenzoates; Rats; Serotonin Antagonists; Skin; Time Factors; Viscera | 1998 |
5-HT is present in nerves of guinea pig sphincter of Oddi and depolarizes sphincter of Oddi neurons.
Topics: 4-Aminobenzoic Acid; 5,7-Dihydroxytryptamine; Animals; Atropine; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Evoked Potentials; Ganglia, Autonomic; Guinea Pigs; Immunohistochemistry; Indazoles; Membrane Potentials; Myenteric Plexus; Nerve Fibers; Neurons; Organ Culture Techniques; para-Aminobenzoates; Serotonin; Serotonin Antagonists; Sphincter of Oddi; Tetrodotoxin; Tropanes | 1998 |
p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.
Topics: 4-Aminobenzoic Acid; Adrenal Medulla; Adrenalectomy; Aminopyridines; Animals; Blood Glucose; Dose-Response Relationship, Drug; Ergolines; Fenclonine; Hyperglycemia; Indoles; Ketanserin; Male; Methysergide; p-Chloroamphetamine; para-Aminobenzoates; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ritanserin; Serotonin; Serotonin Agents; Serotonin Antagonists; Tropisetron | 1998 |
Serotonin receptor agonists that increase cyclic AMP positively regulate IGF-I in mouse mandibular mesenchymal cells.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Cyclic AMP; Cysteine; Embryo, Mammalian; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mandible; Mesoderm; Mice; Nialamide; para-Aminobenzoates; Piperazines; Pyrroles; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
5-HT4 receptors in isolated human corpus cavernosum?
Topics: 4-Aminobenzoic Acid; Adrenergic beta-Antagonists; Benzamides; Humans; Male; Methysergide; Muscle Relaxation; Norepinephrine; para-Aminobenzoates; Penis; Pindolol; Pyrroles; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.
Topics: 4-Aminobenzoic Acid; Aniline Compounds; Animals; Cocaine; Male; Nucleus Accumbens; para-Aminobenzoates; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Chronotropic action of 5-hydroxytryptamine (5-HT) on colonic migrating motor complexes (CMMCs) in the isolated mouse colon.
Topics: 4-Aminobenzoic Acid; Animals; Colon; Cyproheptadine; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Methiothepin; Methoxydimethyltryptamines; Mice; Mice, Mutant Strains; Motor Neurons; Ondansetron; para-Aminobenzoates; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons.
Topics: 4-Aminobenzoic Acid; 5-Methoxytryptamine; Amino Acid Sequence; Animals; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Ion Channels; Ligands; Molecular Sequence Data; para-Aminobenzoates; Patch-Clamp Techniques; Peptide Fragments; Potassium Chloride; Prefrontal Cortex; Pyramidal Cells; Rats; Receptor Cross-Talk; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Reverse Transcriptase Polymerase Chain Reaction; Serotonin Antagonists; Serotonin Receptor Agonists; Transcription, Genetic | 2002 |
5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity.
Topics: 4-Aminobenzoic Acid; Action Potentials; Animals; Benzofurans; Cisapride; Electrophysiology; Indoles; Male; Neurons; para-Aminobenzoates; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 2002 |
Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit.
Topics: 4-Aminobenzoic Acid; Animals; In Vitro Techniques; Indazoles; Male; para-Aminobenzoates; Penis; Piperazines; Pyridines; Rabbits; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Tropanes; Vasoconstriction | 2003 |
3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex.
Topics: 4-Aminobenzoic Acid; Acetylcholine; Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; Ergolines; Hallucinogens; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; para-Aminobenzoates; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Serotonin, 5-HT4; Serotonin Antagonists | 2005 |
Functional roles of 5-hydroxytryptamine 3/4 receptors in neurons of rat dorsal motor nucleus of the vagus.
Topics: 4-Aminobenzoic Acid; 5-Methoxytryptamine; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Granisetron; In Vitro Techniques; Medulla Oblongata; Membrane Potentials; Neurons; para-Aminobenzoates; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vagus Nerve | 2006 |
Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in guinea-pig distal colon?
Topics: Adrenergic Uptake Inhibitors; Animals; Colon; Enteric Nervous System; Evoked Potentials; Feces; Guinea Pigs; Male; Muscle, Smooth; Myenteric Plexus; para-Aminobenzoates; Peristalsis; Physical Stimulation; Reserpine; Serotonin; Serotonin Antagonists; Video Recording | 2013 |