scutellarein has been researched along with 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one* in 2 studies
2 other study(ies) available for scutellarein and 5-7-dihydroxy-6-methoxy-2-phenylchromen-4-one
| Article | Year |
|---|---|
A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases.
Topics: Andrographis; Antineoplastic Agents, Phytogenic; Apigenin; Apocynaceae; Asia, Southeastern; Biflavonoids; Bignoniaceae; Catechin; Diterpenes; Ethnopharmacology; Flavanones; Flavonoids; Hep G2 Cells; Humans; Lamiaceae; Liver Neoplasms; Metabolomics; Plants, Medicinal; Proanthocyanidins | 2018 |
Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase.
Oroxylin A and hispidulin, compounds which are abundant in both Scutellaria and liverwort species, are important lead compounds for the treatment of ischemic cerebrovascular disease. Their enzymatic synthesis requires an O-methyltransferase able to interact with the related flavonoid's 6-OH group, but such an enzyme has yet to be identified in plants. Here, the gene encoding an O-methyltransferase (designated PaF6OMT) was isolated from the liverwort species Plagiochasma appendiculatum. A test of alternative substrates revealed that its strongest preferences were baicalein and scutellarein, which were converted into, respectively, oroxylin A and hispidulin. Allowed a sufficient reaction time, the conversion rate of these two substrates was, respectively, 90% and 100%. PaF6OMT offers an enzymatic route to the synthesis of oroxylin A and hispidulin. Topics: Apigenin; Cerebrovascular Disorders; Cloning, Molecular; Flavanones; Flavones; Flavonoids; Hepatophyta; Humans; Methyltransferases; Substrate Specificity | 2016 |