scopoletin has been researched along with coumarin* in 3 studies
1 review(s) available for scopoletin and coumarin
| Article | Year |
|---|---|
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.
Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of depression and Alzheimer disease and inhibitors of MAO are the most important drugs for their management. Coumarins are a large family of compounds, of natural and synthetic origin, that exhibit a variety of pharmacological activities, including MAO inhibition. The current review highlights the design and synthetic methods of coumarin derivatives as well as coumarins obtained from plant source as MAO inhibitors for treatment of depression and Alzheimer disease with salient finding related to structure-activity relationship. The aim of present review is to find out natural as well as synthetic coumarins as MAO inhibitors. Topics: Alzheimer Disease; Coumarins; Depression; Drug Design; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2013 |
2 other study(ies) available for scopoletin and coumarin
| Article | Year |
|---|---|
Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors.
Alzheimer's disease, one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by declines in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is maintaining levels of acetylcholine by inhibiting acetylcholinesterase (AChE). In the present study, coumarin derivatives were designed and synthesized as AChE inhibitors based on the lead structure of scopoletin. Of those synthesized, pyrrolidine-substituted coumarins 3b and 3f showed ca. 160-fold higher AChE inhibitory activities than scopoletin. These compounds also ameliorated scopolamine-induced memory deficit in mice when administered orally at the dose of 1 and 2 mg/kg. Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Coumarins; Disease Models, Animal; Enzyme Activation; Male; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Protein Binding; Pyrrolidines; Scopoletin; Structure-Activity Relationship | 2014 |
A coumarin from Mallotus resinosus that mediates DNA cleavage.
A crude extract prepared from roots of Mallotus resinosus exhibited significant Cu(2+)-dependent DNA strand scission activity and was thus selected for bioassay-guided fractionation. Scopoletin (1), a simple coumarin, was identified as the active principle responsible for DNA cleavage activity of the crude extract. The DNA strand scission activity of 1, as well as that of three structural analogues, is reported. Topics: Coumarins; DNA; DNA Damage; Mallotus Plant; Philippines; Plant Roots; Plants, Medicinal; Scopoletin | 2004 |