scoparone has been researched along with warfarin in 140 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (12.86) | 18.7374 |
| 1990's | 20 (14.29) | 18.2507 |
| 2000's | 29 (20.71) | 29.6817 |
| 2010's | 59 (42.14) | 24.3611 |
| 2020's | 14 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chandhoke, N | 1 |
| Atal, CK; Rao, PG; Soni, A; Zutshi, U | 1 |
| Huang, HC; Lee, CR; Lee, MC; Lee, YT; Weng, YI | 1 |
| Kato, S; Yamamoto, K | 2 |
| Blaauboer, BJ; Klein, WR; Noordhoek, J; van 't Klooster, GA; van Miert, AS; Woutersen-van Nijnanten, FM | 1 |
| Chang, JH; Chen, CC; Huang, HC; Huang, YL; Lee, YT | 1 |
| Huang, JZ; Wan, YD; Xu, JH; Zang, OZ; Zheng, ZY | 1 |
| Chao, PD; Chu, SH; Huang, HC | 1 |
| Blaauboer, BJ; Mennes, WC; Noordhoek, J; Timmerman, A; van Holsteijn, CW | 1 |
| Berger, M; Hausen, BM | 1 |
| Fujimura, H; Katayama, T; Kobayashi, G; Matsuda, H; Yamahara, J | 2 |
| Blaauboer, BJ; Hassing, IG; Mennes, WC; Van Pelt, FN | 1 |
| Fujimura, H; Iwamoto, M; Kobayashi, G; Matsuda, H; Yamahara, J | 1 |
| Zhang, QW; Zhang, YZ | 2 |
| Chen, MH | 1 |
| Sharma, ML | 1 |
| Greischel, A; Müller-Enoch, D | 1 |
| Kato, S; Shimomura, H; Yamamoto, K | 1 |
| Funke, E; Kling, L; Legrum, W | 1 |
| Müller-Enoch, D; Sato, N; Thomas, H | 1 |
| Chen, YL; Huang, HC; Lee, YT; Weng, YI; Yu, YJ | 1 |
| Liu, ZS; Sun, H; Wang, XJ | 1 |
| Du, GY; Jing, HD; Lü, F; Ye, WH | 1 |
| Huang, JC; Sun, AX; Wang, RX; Wang, XR | 1 |
| Kossakowski, J; Zawadowski, T | 1 |
| Blaauboer, BJ; Noordhoek, J; van 't Klooster, GA; van Miert, AS; Woutersen-van Nijnanten, FM | 1 |
| Huang, JC; Sun, AX; Wang, XR | 1 |
| Desager, JP; Harvengt, C; Horsmans, Y | 1 |
| Chen, YL; Huang, HC; Jan, TR; Lee, CR; Lee, YT; Weng, YI | 1 |
| Mennes, WC; Nijmeijer, SM; Noordhoek, J; Rozema, AW; van Miert, AS; Witkamp, RF | 1 |
| Blaauboer, BJ; Luijckx, NB; Mennes, WC; Noordhoek, J; Wortelboer, HM | 1 |
| Liu, SJ; Zhou, SW | 1 |
| Cho, HR; Choi, DH; Ju, SA; Kim, BS; Ko, BK; Lee, EA; Lee, JS; Lee, KA; Lee, SG; Lee, YJ; Nam, CW; Park, KM | 1 |
| Hagemeyer, CE; Knoth, R; Kurz, G; Meyer, RP; Volk, B | 1 |
| Ortega, X; Pérez, LM | 1 |
| Li, S; Liu, B; Mao, Y; Peng, W; Wei, H | 1 |
| Chi, YS; Chung, JH; Heo, MY; Jo, BK; Kim, HP | 1 |
| Castañeda, P; Ortega, X; Perez, LM; Polanco, R | 1 |
| Fang, Y; Li, Z; Watanabe, Y | 1 |
| WRIGLEY, TC | 1 |
| DJERASSI, C; SHAPIRO, RH | 1 |
| Eisenstein, M | 1 |
| Gao, XZ; Yao, W; Zhang, SL; Zhao, Y; Zhou, CX | 1 |
| Chatterjee, SS; Dertinger, H; Eschbach, E; Gottwald, E; Knedlitschek, G; Nöldner, M; Weibezahn, KF | 1 |
| Baek, SH; Chai, KY; Chung, HT; Jang, SI; Kim, YJ; Kwak, GB; Kwak, KC; Kwon, TO; Lee, WY; Yun, YG | 1 |
| Agabbio, M; D'hallewin, G; Dore, A; Molinu, MG; Venditti, T | 1 |
| Jang, SI; Kim, HJ; Kim, HY; Kim, YC; Kim, YJ; Lee, JC; You, YO; Yu, HH; Yun, YG | 1 |
| Ahn, JH; Hur, HG; Kim, BG; Lee, Y; Lim, Y | 1 |
| Mohanlall, V; Odhav, B | 1 |
| Weng, LJ; Zhang, SL; Zhao, Y; Zheng, W; Zhou, CX | 1 |
| Jhee, EC; Koo, JH; Kwon, KB; Lee, JH; Park, BH; Park, JW; Sohn, HS; Song, YG; Yang, JY | 1 |
| Cui, JR; Ran, FX; Wang, RQ; Wu, J; Xu, B; Yang, XW | 1 |
| Jhee, EC; Kim, EK; Kwon, KB; Lee, HK; Lee, JH; Park, BH; Park, JW; Yang, JY | 1 |
| Yu, L; Zhang, DM | 1 |
| Cao, H; Liu, L; Lv, H; Sun, H; Sun, W; Wang, X | 1 |
| Gao, XX; Li, K; Li, YQ; Wang, Q; Yu, ZG | 1 |
| Cao, H; Jiao, G; Lv, H; Sun, H; Sun, W; Wang, X; Zhang, G; Zhao, L; Zhou, D | 1 |
| Cao, H; Liu, L; Lv, H; Sun, H; Sun, W; Wang, P; Wang, X | 2 |
| Choi, DH; Huang, HS; Lee, HJ; Lee, MK; Lim, SC; Yang, YJ | 1 |
| Chen, ZT; Liang, YF; Liu, LH | 1 |
| Choi, HS; Huang, HS; Lee, BK; Lee, CK; Lee, HJ; Lee, MK; Lim, SC; Yang, YJ | 1 |
| Choi, YH; Yan, GH | 1 |
| Yang, XW; Zhang, YB | 1 |
| Ye, XQ; Zhao, XM; Zhu, DY | 1 |
| Lee, BK; Lee, CK; Lee, HJ; Lee, MK; Lim, SC; Yang, YJ | 1 |
| Atmaca, M; Deniz Obay, B; Ketani, A; Murat Bilgin, H; Ozekinci, S; Taşdemir, E | 1 |
| Dai, C; He, H; Li, X; Song, L; Tang, H; Wang, H | 1 |
| Li, S; Row, KH; Tian, M | 1 |
| Gang, GT; Hwang, JH; Kim, YH; Lee, CH; Lee, HS; Noh, JR; Oh, WK; Song, KS; Yang, KJ | 1 |
| Chen, JX; Huang, SH; Shao, M; Wang, Y; Ye, WC | 1 |
| Gang, GT; Hwang, JH; Kim, YH; Lee, CH; Lee, HS; Ly, SY; Noh, JR; Oh, WK; Song, KS | 1 |
| Deng, R; Shi, D; Yan, B; Yang, D; Yang, J | 1 |
| Atmaca, M; Bilgin, HM; Diken, H; Kale, E; Kelle, M; Obay, BD | 1 |
| Hwang, TL; Kuo, PC; Kuo, YC; Leu, YL; Lin, YT | 1 |
| Jiao, G; Sun, H; Sun, W; Wang, X; Yuan, Y; Zhang, A | 1 |
| Chen, H; Chen, X; Deng, Y; He, K; Li, X; Ye, X; Yuan, L | 1 |
| Sun, H; Wang, X; Yin, Q; Zhang, A | 1 |
| Fu, SS; Han, J; Jin, SX; Jin, SY; Li, RS; Lv, JL; Xiao, XH; Yuan, HL | 1 |
| Dou, S; Sun, H; Sun, W; Wang, P; Wang, X; Wu, X; Zhang, A | 1 |
| Alcantara, TT; Campello, CC; Cavalcanti, ES; de Morais, SM; Falcão, MJ; Ferreira, PA; Vieira, IG; Vila-Nova, NS; Wilson, M | 1 |
| Liu, J; Wang, Q; Wang, W; Yang, X; Zhao, A | 1 |
| Sun, H; Sun, W; Wang, X; Wu, G; Yuan, Y; Zhang, A | 1 |
| Choi, JS; Kang, JW; Kim, DW; Kim, YS; Lee, SM | 1 |
| Gang, GT; Hwang, JH; Kim, KS; Kim, YH; Lee, CH; Lee, IK; Ly, SY; Noh, JR; Oh, WK; Yeo, SH | 1 |
| Dmoszynska-Graniczka, M; Gawda, P; Grabarska, A; Jeleniewicz, W; Kielbus, M; Klatka, J; Marston, A; Polberg, K; Skalicka-Wozniak, K; Stepulak, A | 1 |
| Cestari, SH; da Silveira Chagas, A; de Almeida, LD; Di Stasi, LC; Luchini, AC; Rodrigues-Orsi, P; Seito, LN; Witaicenis, A | 1 |
| Cho, WJ; Harris, RA; Kim, HJ; Kim, JK; Kim, JY; Lee, IK; Lee, JT; Park, KG | 1 |
| Groundwater, P; Li, P; Liu, J; Lu, D; Narlawar, R; Yan, Z | 1 |
| Ebrahimi, F; Iranshahi, M; Iranshahy, M; Kasaian, J; Masullo, M; Piacente, S | 1 |
| Chen, YG; Liu, YY; Yu, H; Yuan, F; Zhou, F | 1 |
| Cheng, L; Jiang, C; Wang, Z; Zhang, S | 1 |
| Cheng, D; Cui, XD; Li, J; Li, MJ; Wang, P; Zhou, B | 1 |
| Hu, Y; Li, B; Li, J; Li, X; Niu, N; Zhang, H | 1 |
| Ippolito, A; Sanzani, SM; Schena, L | 1 |
| Sun, H; Wang, X; Zhang, A | 1 |
| Jang, HD; Lee, SH | 1 |
| Del Río, JA; Díaz, L; Ortuño, A; Pérez-Gilabert, M | 1 |
| Choi, SH; Jeon, JH; Kim, JK; Lee, IK; Oh, CJ; Park, S | 1 |
| Choi, WS; Lee, GR; Lee, SE; Oh, S; Son, DJ | 1 |
| Chodisetti, B; Gandi, S; Giri, A; Kishor, PB; Rao, K | 1 |
| Guan, Y; Han, Y; Qiu, S; Sun, H; Wang, X; Yan, G; Zhang, A; Zhang, T | 1 |
| Fu, Y; Li, X; Lin, L; Liu, L; Lu, P; Wang, P; Zeng, H; Zhen, P; Zhu, H | 1 |
| Chen, ZH; Cheng, D; Li, MJ; Liu, SZ; Wang, P; Zhou, B | 1 |
| Ahn, WS; Li, G; Row, KH | 1 |
| Cai, J; Du, F; Gong, A; Huang, H; Peng, W; Wei, H; Xu, M; Xu, P; Zhang, Y; Zhou, M | 1 |
| Fang, H; Liu, C; Song, Q; Sun, H; Wang, L; Wang, X; Yu, J; Zhang, A; Zhou, X | 1 |
| Hsueh, TP; Lin, WL; Tsai, TH | 1 |
| Cho, DY; Choi, DK; Ganesan, P; Kim, BW; Kim, J; Ko, HM; Lee, JT; Park, JI; Yun, YS | 1 |
| Chen, H; Deng, S; He, R; Huang, S; Huang, Y; Li, J; Liu, B; Nie, H; Yang, R; Zhang, Y; Zhou, D | 1 |
| Bian, YQ; Cao, HY; Dong, S; Li, JY; Liu, P; Sun, L; Sun, MY; Sun, RF; Wu, C | 1 |
| Liu, X; Zhao, X | 1 |
| Chan, YY; Hung, HY; Hwang, TL; Kuo, PC; Wu, TS | 1 |
| Auriola, S; Fayyaz, A; Juvonen, RO; Makwinja, S; Raunio, H | 1 |
| Chen, B; Shi, J; Wang, M; Wang, Y | 1 |
| Amaro, M; Ghose, A; Hof, M; Kovaricek, P; Sykora, J | 1 |
| Han, ZM; Li, CY; Wang, H; Xia, J; Zhang, QM | 1 |
| Geng, X; Ma, J; Wan, C; Wei, Y | 1 |
| Fu, B; Ma, X; Mu, C; Su, Y; Yu, F | 1 |
| Cai, Y; Hu, S; Li, Y; Lu, C; Peng, K; Yang, Z | 1 |
| Hsueh, TP; Tsai, TH | 1 |
| Enrique, JF; Ivan, MD; Macrina, FM; Manasés, GC; Margarita, AF; Maribel, HR; Nayeli, MB; Rafael, BP | 1 |
| Cui, L; Jung, SH; Kim, B; Kim, J; Lee, GB; Lee, HM; Ryu, Y; Won, KJ | 1 |
| Deng, X; Jiang, Q; Li, G; Liu, B; Xin, S; Xu, K; Zhang, J; Zhang, N | 2 |
| Cao, J; Chen, Y; Dong, X; Peng, LQ; Wang, SL; Xie, T; Yang, J; Zhen, XT | 1 |
| Ju, X; Li, Z; Wang, L; Xu, F; Yao, Y | 1 |
| Chen, X; Cui, B; Fan, X; Feng, H; Hui, Y; Lin, L; Mao, L; Sun, C; Wang, B; Wang, X; Yu, Q; Yu, Z; Zhang, J; Zhao, T; Zhao, X | 1 |
| Chen, J; Chen, Y; Fang, L; Gao, H; Li, H; Lin, J; Lv, R; Lyu, L; Wang, W; Xu, F; Yan, T | 1 |
| Ding, W; Guo, F; Liu, J; Liu, S; Ning, Y; Wan, F; Zhou, H | 1 |
| Budzyńska, B; El Sayed, NS; Gertsch, J; Kowalczyk, J; Kurach, Ł; Pellegata, D; Skalicka-Woźniak, K | 1 |
| Ding, W; Guo, F; Liu, J; Wan, F; Zhou, H | 1 |
| Kim, B; Kwon, IK; Lee, JY; Moon, HJ; Park, KR; Yun, HM | 1 |
| Cao, H; Gao, Y; Guo, K; Huang, X; Li, J; Li, T; Mo, S; Wei, R; Wu, J; Zhang, K | 1 |
| Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ | 1 |
| Chen, HJ; Hsieh, SC; Hsu, KM; Liao, YC; Su, NW; Yeh, YT | 1 |
| Budzyńska, B; El Sayed, NS; Ibrahim, WW; Skalicka-Woźniak, K | 1 |
2 review(s) available for scoparone and warfarin
| Article | Year |
|---|---|
Therapeutic mechanism of Yīn-Chén-Hāo decoction in hepatic diseases.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Antiviral Agents; Artemisia; Ascites; Chlorogenic Acid; Clinical Trials as Topic; Coumarins; Drugs, Chinese Herbal; Emodin; Fatty Liver; Gardenia; Humans; Iridoids; Liver Diseases; Plant Extracts; Rheum | 2017 |
Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action.
Topics: Animals; Artemisia; Coumarins; Drugs, Chinese Herbal; Humans; Liver; Liver Diseases; Medicine, Chinese Traditional; Non-alcoholic Fatty Liver Disease | 2020 |
138 other study(ies) available for scoparone and warfarin
| Article | Year |
|---|---|
Scoparone: effect on reproductive processes in rats.
Topics: Animals; Antihypertensive Agents; Coumarins; Embryo Implantation; Female; Fetal Death; Male; Pregnancy; Rats; Reproduction | 1979 |
Absorption, distribution & excretion of scoparone: a potent hypotensive agent.
Topics: Animals; Antihypertensive Agents; Coumarins; Intestinal Absorption; Mice; Tissue Distribution | 1978 |
Vasodilator effect of scoparone (6,7-dimethoxycoumarin) from a Chinese herb.
Topics: Animals; Coumarins; Cyclic GMP; Drugs, Chinese Herbal; Epoprostenol; Immunosuppressive Agents; In Vitro Techniques; Nitric Oxide; Rats; Superoxides; Vasodilator Agents | 1992 |
Comparative effects of chloroflavone congeners as inducers of hepatic microsomal monooxygenases in rats.
Topics: Aminopyrine N-Demethylase; Animals; Coumarins; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism | 1992 |
Effects of various medium formulations and attachment substrata on the performance of cultured ruminant hepatocytes in biotransformation studies.
Topics: Animals; Biotransformation; Cattle; Cell Adhesion; Cells, Cultured; Collagen; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Ethylmorphine; Fatty Acids; Female; Fibronectins; Glucose; Goats; L-Lactate Dehydrogenase; Liver; Male; Models, Biological; Phenolsulfonphthalein; Proteins; Time Factors | 1992 |
Possible mechanism of immunosuppressive effect of scoparone (6,7-dimethoxycoumarin).
Topics: Alloxan; Antihypertensive Agents; Arachidonic Acid; Cells, Cultured; Coumarins; Cyclosporine; Dose-Response Relationship, Drug; Eicosanoids; Genistein; Humans; Immunosuppressive Agents; Isoflavones; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Receptors, Interleukin-2 | 1992 |
[Influence of 6,7-dimethoxycoumarin on toxicity and pharmacodynamics of cyclophosphamide].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Corticosterone; Coumarins; Cyclophosphamide; DNA; Female; Lethal Dose 50; Male; Mice; Neoplasms, Experimental; Rats; Rats, Inbred Strains; RNA | 1990 |
Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties.
Topics: Animals; Coumarins; Emodin; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Inbred Strains; Thoracic Arteries | 1991 |
Biotransformation of scoparone used to monitor changes in cytochrome P450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeys.
Topics: Animals; Biotransformation; Cells, Cultured; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Liver; Macaca fascicularis; Mesocricetus; Rats; Species Specificity | 1991 |
Using the scoparone O-demethylase assay for categorizing types of hepatic microsomal monooxygenase inducers.
Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1989 |
The sensitizing capacity of coumarins (III).
Topics: 4-Hydroxycoumarins; Animals; Coloring Agents; Cosmetics; Coumarins; Dermatitis, Contact; Drug Eruptions; Female; Guinea Pigs; Lasers; Perfume; Scopoletin; Umbelliferones | 1989 |
Vascular dilatory action of Artemisia capillaris bud extracts and their active constituent.
Topics: Animals; Antihypertensive Agents; Coumarins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Plants, Medicinal; Rabbits; Vasodilator Agents | 1989 |
The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug Artemisiae capillaris flos, on the heart.
Topics: Animals; Antihypertensive Agents; Coumarins; Drugs, Chinese Herbal; Electroencephalography; Heart; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1989 |
Application of high-performance liquid chromatographic analysis of scoparone and its metabolites in the study of cytochrome P450 differentiation in vitro.
Topics: Animals; Antihypertensive Agents; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Liver; Rats; Scopoletin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1989 |
Vascular dilatory action of the Chinese crude drug. II. Effects of scoparone on calcium mobilization.
Topics: Animals; Antihypertensive Agents; Calcium; Coumarins; Drugs, Chinese Herbal; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rabbits | 1989 |
[Determination of choleretic constituents in Artemisia scoparia Waldst. et Kit. by TLC densitometry].
Topics: Acetophenones; Chlorogenic Acid; Cholagogues and Choleretics; Chromatography, Thin Layer; Coumarins; Densitometry; Drugs, Chinese Herbal | 1989 |
[Studies on the chemical constituents of Pueraria lobata].
Topics: Antihypertensive Agents; Coumarins; Fabaceae; Hydantoins; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phytotherapy; Plants, Medicinal; Sitosterols | 1985 |
Mechanism of hypotensive action of scoparone.
Topics: Animals; Antihypertensive Agents; Cats; Coumarins; Dogs; Female; Guinea Pigs; Hemodynamics; Male; Muscle, Smooth; Rabbits; Rats | 1988 |
Differentiation of cytochrome P-450 activities with scoparone as substrate. A rapid one-step HPLC-analysis.
Topics: Animals; Antihypertensive Agents; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Male; Rats; Rats, Inbred Strains; Scopoletin; Spectrophotometry, Ultraviolet | 1988 |
[Separation and determination of the cholagogic components in bin hao (Artemisia scoparia) by HPLC].
Topics: Acetophenones; Chlorogenic Acid; Cholagogues and Choleretics; Chromatography, High Pressure Liquid; Coumarins; Medicine, Chinese Traditional; Plants, Medicinal | 1986 |
Gas chromatographic-mass spectrometric analysis of monodemethylated metabolites of 6,7- and 7,8-dimethoxycoumarin isomers.
Topics: Coumarins; Gas Chromatography-Mass Spectrometry; Humans; Liver; Stereoisomerism | 1986 |
Radioisomers of scoparone (6,7-dimethoxycoumarin) as a tool for in vivo differentiation of various hepatic monooxygenase inducers in mice using the breath test technique.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Coumarins; Dealkylation; Dose-Response Relationship, Drug; Enzyme Induction; Liver; Male; Mice; Mice, Inbred C57BL; Oxygenases; Respiration | 1984 |
O-demethylation of scoparone and studies on the scoparone-induced spectral change of cytochrome P-450 in rat liver microsomes.
Topics: Animals; Antihypertensive Agents; Coumarins; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1981 |
Morphological evidence for the antiatherogenic effect of scoparone in hyperlipidaemic diabetic rabbits.
Topics: Animals; Antihypertensive Agents; Aorta; Aortic Diseases; Arteriosclerosis; Coumarins; Diabetes Mellitus, Experimental; Hyperlipidemias; Male; Microscopy, Electron, Scanning; Rabbits | 1994 |
[Quantitative analysis of 6,7-dimethylesculetin and capillarisine in Artemisia capillaris Thunb. and prescriptions containing the crude drug].
Topics: Cholagogues and Choleretics; Chromones; Coumarins; Drug Combinations; Drugs, Chinese Herbal; Quality Control | 1994 |
[Effects of 6,7-dimethoxycoumarin on experimental arrhythmia].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coumarins; Electrocardiography; Female; Male; Mice; Ouabain; Procainamide; Rats; Rats, Wistar | 1993 |
[Effects of scoparone on hemodynamics in anesthetized rabbits].
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Circulation; Coumarins; Dose-Response Relationship, Drug; Male; Papaverine; Pyrazines; Rabbits; Vasodilator Agents | 1993 |
Synthesis of aminoalkanols derivatives of 6,7-dimethoxy-2H-1-benzopyran-2-one with antiarrhythmic activity.
Topics: Anti-Arrhythmia Agents; Benzopyrans; Chromatography, Thin Layer; Coumarins; Magnetic Resonance Spectroscopy | 1993 |
Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies.
Topics: Animals; Biotransformation; Cattle; Cell Differentiation; Cells, Cultured; Coumarins; Cytochrome P-450 Enzyme System; Ethylmorphine; Female; Glucuronates; Goats; Liver; Male; Naphthols; Oxidation-Reduction; Phenolsulfonphthalein; Rats; Rats, Wistar; Sex Factors; Sheep; Species Specificity; Sulfates; Trimethoprim; Xenobiotics | 1994 |
[Effects of 6,7-dimethoxycoumarin on left ventricular function and hemodynamics in anesthetized cats].
Topics: Animals; Blood Pressure; Cats; Coumarins; Hemodynamics; Male; Myocardial Contraction; Oxygen Consumption; Ventricular Function, Left | 1993 |
Scoparone O-demethylase assay is not useful to differentiate the effects of model inducers of cytochrome P-450 in rabbit and guinea pig liver.
Topics: Animals; Biomarkers; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Humans; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, O-Demethylating; Phenobarbital; Rabbits; Rats; Rats, Wistar; Species Specificity | 1993 |
Protection by scoparone against the alterations of plasma lipoproteins, vascular morphology and vascular reactivity in hyperlipidaemic diabetic rabbit.
Topics: Animals; Blood Vessels; Coumarins; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hyperlipidemias; Hypolipidemic Agents; In Vitro Techniques; Lipoproteins; Rabbits; Vasodilation | 1993 |
Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroids and the involvement of constitutive P450 enzymes.
Topics: Animals; Antibodies, Monoclonal; Antihypertensive Agents; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Gonadal Steroid Hormones; In Vitro Techniques; Male; Microsomes, Liver; Orchiectomy; Ovariectomy; Rats; Rats, Wistar; Sex Characteristics | 1993 |
Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver.
Topics: Animals; Antihypertensive Agents; Benzoflavones; beta-Naphthoflavone; Biotransformation; Clofibrate; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Species Specificity | 1993 |
6,7-dimethoxycoumarin attenuated cisplatin-induced DNA interstrand crosslink and DNA-protein crosslink in primary cultured rabbit kidney proximal tubular cells.
Topics: Animals; Cells, Cultured; Cisplatin; Coumarins; DNA; DNA Damage; DNA-Binding Proteins; Female; Kidney Tubules, Proximal; Male; Rabbits | 1999 |
Cold preservation of rat cultured hepatocytes: the scoparone effect.
Topics: Adenosine; Alanine Transaminase; Allopurinol; Animals; Antihypertensive Agents; Cell Survival; Cold Temperature; Coumarins; Glutathione; Hepatocytes; Hypertonic Solutions; Insulin; Kinetics; Malondialdehyde; Organ Preservation Solutions; Raffinose; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Time Factors; Tissue Preservation; Vitamin E | 2000 |
Oxidative hydrolysis of scoparone by cytochrome p450 CYP2C29 reveals a novel metabolite.
Topics: Animals; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Kinetics; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxygenases; Rats; Rats, Sprague-Dawley | 2001 |
Participation of the phosphoinositide metabolism in the hypersensitive response of Citrus limon against Alternaria alternata.
Topics: Alternaria; Caffeine; Calcium; Citrus; Coumarins; Fibrinolytic Agents; Heparin; Inositol 1,4,5-Trisphosphate; Neomycin; Phenylalanine Ammonia-Lyase; Phosphatidylinositols; Phosphodiesterase Inhibitors; Protein Synthesis Inhibitors; Seeds; Signal Transduction | 2001 |
[Studies on chemical constituents in the fruit of Canarium album Raeusch].
Topics: Burseraceae; Coumarins; Fruit; Plants, Medicinal; Scopoletin | 1999 |
Effects of the chestnut inner shell extract on the expression of adhesion molecules, fibronectin and vitronectin, of skin fibroblasts in culture.
Topics: 3T3 Cells; Animals; Blotting, Western; Cell Adhesion Molecules; Cell Division; Cells, Cultured; Coumarins; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins; Fluorescent Antibody Technique; Mice; Nuts; Plant Extracts; Skin; Vitronectin | 2002 |
Signal transduction in lemon seedlings in the hypersensitive response against Alternaria alternata: participation of calmodulin, G-protein and protein kinases.
Topics: Alternaria; Calmodulin; Cholera Toxin; Citrus; Coumarins; Enzyme Induction; Heterotrimeric GTP-Binding Proteins; Phenylalanine Ammonia-Lyase; Phosphorylation; Phytoalexins; Plant Extracts; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Seeds; Sesquiterpenes; Signal Transduction; Terpenes; Trifluoperazine | 2002 |
Pharmacokinetics of a novel anti-asthmatic, scoparone, in the rabbit serum assessed by a simple HPLC method.
Topics: Animals; Anti-Asthmatic Agents; Area Under Curve; Chromatography, High Pressure Liquid; Coumarins; Female; Half-Life; Injections, Intravenous; Male; Metabolic Clearance Rate; Rabbits | 2003 |
Ayapin, scopoletin and 6,7-dimethoxycoumarin from Dendrobium thyrsiflorum (Reichb. f.).
Topics: Coumarins; Dendrobium; Plants; Scopoletin | 1960 |
MASS SPECTOMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS. LXVI. MASS SPECTRAL FRAGMENTATION OF 6,7-DIMETHOXYCOUMARIN.
Topics: Chemical Phenomena; Chemistry; Coumarins; Research; Spectrum Analysis | 1965 |
A modern examination of an ancient cure.
Topics: Animals; Bilirubin; Coumarins; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Humans; Infant, Newborn; Jaundice, Neonatal; Mice; Mice, Knockout; Mice, Transgenic; Receptors, Androgen | 2004 |
[Studies on the chemical constituents in herb of Ranunculus sceleratus].
Topics: Benzaldehydes; Catechols; Cholestenones; Coumarins; Hydroxybenzoates; Plants, Medicinal; Ranunculus | 2005 |
Microstructured scaffolds for liver tissue cultures of high cell density: morphological and biochemical characterization of tissue aggregates.
Topics: Actins; Albumins; Animals; Cells, Cultured; Coumarins; Culture Media; Cytochrome P-450 Enzyme System; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Fructose-Bisphosphate Aldolase; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tyrosine Transaminase; Xenobiotics | 2005 |
Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS.
Topics: Animals; Anti-Inflammatory Agents; Artemisia; Blotting, Western; Cell Line; Cell Survival; Coumarins; Cyclooxygenase 2; Cytokines; Dinoprostone; Inflammation Mediators; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Stimulation, Chemical; Tetrazolium Salts; Thiazoles | 2005 |
Sodium carbonate treatment induces scoparone accumulation, structural changes, and alkalinization in the albedo of wounded citrus fruits.
Topics: Carbonates; Citrus; Coumarins; Fruit; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Penicillium; Plant Diseases | 2005 |
Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Chemokine CCL2; Coumarins; Dose-Response Relationship, Drug; Humans; I-kappa B Proteins; Interleukin-8; Monocytes; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Tetradecanoylphorbol Acetate | 2006 |
Production of three O-methhylated esculetins with Escherichia coli expressing O-methyltransferase from poplar.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Coumarins; Escherichia coli; Industrial Microbiology; Methylation; Plant Proteins; Populus; Protein O-Methyltransferase; Scopoletin; Umbelliferones | 2006 |
Biocontrol of aflatoxins B1, B2, G1, G2, and fumonisin B1 with 6,7-dimethoxycoumarin, a phytoalexin from Citrus sinensis.
Topics: Aflatoxin B1; Aflatoxins; Chromatography, High Pressure Liquid; Citrus sinensis; Consumer Product Safety; Coumarins; Food Irradiation; Food Preservation; Fumonisins; Humans; Pest Control, Biological; Phytoalexins; Plant Extracts; Sesquiterpenes; Terpenes; Ultraviolet Rays | 2006 |
[Studies on the chemical constituents in herb of Ranunculus japonicus].
Topics: Coumarins; Flavonoids; Plants, Medicinal; Ranunculus | 2006 |
Stimulation of melanogenesis by scoparone in B16 melanoma cells.
Topics: Animals; Cell Line, Tumor; Coumarins; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Intramolecular Oxidoreductases; Isoquinolines; Melanins; Melanoma, Experimental; Membrane Glycoproteins; Mice; Monophenol Monooxygenase; Oxidoreductases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides | 2006 |
[Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro].
Topics: Antineoplastic Agents, Phytogenic; Benzopyrans; Butyrates; Cell Line, Tumor; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esculin; Humans; Molecular Structure; Umbelliferones; Urinary Bladder Neoplasms | 2007 |
Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coumarins; Down-Regulation; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Insulin Secretion; Insulinoma; Interferon-gamma; Interleukin-1beta; NF-kappa B; Nitric Oxide Synthase; Nitrites; Protein Transport; Rats; Vasodilator Agents | 2007 |
[Studies on chemical constituents from fruits of Paliurus ramosissimus].
Topics: 5-Methoxypsoralen; Coumarins; Fruit; Furocoumarins; Methoxsalen; Plants, Medicinal; Rhamnaceae; Umbelliferones | 2006 |
Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.
Topics: Animals; Bile; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Coumarins; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Urinalysis | 2007 |
Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Coumarins; Male; Medicine, Chinese Traditional; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2007 |
Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation.
Topics: Administration, Oral; Animals; Anthraquinones; Chromatography, Liquid; Chromones; Coumarins; Drugs, Chinese Herbal; Emodin; Male; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2008 |
Pharmacokinetic studies of a Chinese triple herbal drug formula.
Topics: Administration, Oral; Animals; Calibration; Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Iridoids; Limit of Detection; Male; Rats; Rats, Wistar; Reproducibility of Results | 2008 |
Effect of scoparone on neurite outgrowth in PC12 cells.
Topics: Animals; Antihypertensive Agents; Calcium; Coumarins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Nerve Growth Factor; Neurites; PC12 Cells; Rats; Time Factors | 2008 |
Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation.
Topics: Algorithms; Animals; Calibration; Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Half-Life; Iridoids; Male; Rats; Rats, Wistar; Reproducibility of Results | 2008 |
[Studies on chemical constituents of Ranunculus japonicus].
Topics: 1-Butanol; Acetates; Alkanes; Coumarins; Drugs, Chinese Herbal; Ethanol; Flavones; Flavonoids; Furans; Hydroxybenzoates; Luteolin; Ranunculus; Scopoletin; Spectrometry, Mass, Electrospray Ionization | 2008 |
Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Survival; Coumarins; Cyclic AMP; Cytotoxins; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Extracellular Fluid; Intracellular Fluid; Levodopa; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Protein Kinases; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase; Vasodilator Agents | 2009 |
Anti-allergic effects of scoparone on mast cell-mediated allergy model.
Topics: Animals; Anti-Allergic Agents; Calcium; Coumarins; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; I-kappa B Proteins; Immunoglobulin E; Inflammation Mediators; Male; Mast Cells; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Passive Cutaneous Anaphylaxis; Phosphorylation; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2009 |
A simple RP-HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study.
Topics: Angelica; Animals; Chemical Fractionation; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coumarins; Drug Stability; Linear Models; Male; Plant Roots; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2010 |
[Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B. Chang].
Topics: Chromatography; Citrus; Coumarins; Fruit; Hydroxybenzoates; Phenols; Sitosterols | 2009 |
Effects of scoparone on dopamine release in PC12 cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Coumarins; Cyclic AMP-Dependent Protein Kinases; Dopamine; Drug Evaluation, Preclinical; Imines; PC12 Cells; Phosphorylation; Potassium; Rats; Synapsins; Vasodilator Agents | 2010 |
Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Coumarins; Hymecromone; Male; Rats; Rats, Sprague-Dawley; Umbelliferones | 2011 |
[Main chemical components for clearing heat and relieving sore throat in different germplasm of Canarium album].
Topics: Burseraceae; Chromatography, High Pressure Liquid; Coumarins; Drug Synergism; Drugs, Chinese Herbal; Fever; Gallic Acid; Hot Temperature; Humans; Pharyngitis; Scopoletin | 2010 |
Effect of mobile phase additives on the resolution of four bioactive compounds by RP-HPLC.
Topics: Artemisia; Caffeic Acids; Chlorogenic Acid; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coumarins; Rutin | 2010 |
Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Coumarins; Dietary Fats; Fagaceae; Hep G2 Cells; Hepatocytes; Humans; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Nitroreductases; Nuts; Oxidants; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Scopoletin; tert-Butylhydroperoxide; Thiobarbituric Acid Reactive Substances | 2010 |
[Studies on the chemical constituents from Lobelia chinensis].
Topics: Apigenin; Coumarins; Glucosides; Lobelia; Plant Extracts; Plants, Medicinal; Quercetin | 2010 |
Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice.
Topics: Animals; Blotting, Western; Catalase; Chemical and Drug Induced Liver Injury, Chronic; Coumarins; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Ethanol; Fagaceae; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Plant Extracts; Scopoletin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides | 2011 |
Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Cholagogues and Choleretics; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Synergism; Genes, Reporter; Glucuronosyltransferase; Hepatocytes; Humans; Mice; Microsomes, Liver; Promoter Regions, Genetic; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transfection | 2011 |
The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Coumarins; gamma-Glutamyltransferase; Hymecromone; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Umbelliferones | 2011 |
Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Butyrates; Cell Degranulation; Coumarins; Drugs, Chinese Herbal; HeLa Cells; Herpesvirus 1, Human; Humans; Isomerism; Leukocyte Elastase; Lobelia; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Neutrophils; Pyrroles; Superoxides; Viral Plaque Assay; Virus Replication; Young Adult | 2011 |
Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples.
Topics: Animals; Anthraquinones; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coumarins; Drug Synergism; Drugs, Chinese Herbal; Iridoids; Linear Models; Male; Models, Chemical; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity | 2012 |
Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography.
Topics: Acetates; Chromatography, Thin Layer; Coumarins; Countercurrent Distribution; Furaldehyde; Hexanes; Ipomoea batatas; Methanol; Plant Extracts; Silica Gel; Water | 2012 |
Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry.
Topics: Administration, Oral; Animals; Artemisia; Chromatography, High Pressure Liquid; Coumarins; Liver Diseases; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tissue Distribution | 2012 |
Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Liver; Models, Biological; Rats; Rats, Sprague-Dawley; Validation Studies as Topic | 2012 |
Metabolomics study on the hepatoprotective effect of scoparone using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Coumarins; Cytoprotection; Liver; Metabolomics; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2013 |
Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone.
Topics: 4-Butyrolactone; Animals; Annona; Antiprotozoal Agents; Artemia; Biological Assay; Brazil; Chromatography, Thin Layer; Coumarins; Dose-Response Relationship, Drug; Fabaceae; Furans; Leishmania; Plant Extracts | 2013 |
[A new natural product from root of Angelica dahurica cv. Qibaizhi].
Topics: Angelica; China; Coumarins; Drugs, Chinese Herbal; Furocoumarins; Molecular Structure; Plant Roots | 2012 |
Proteomics analysis of hepatoprotective effects for scoparone using MALDI-TOF/TOF mass spectrometry with bioinformatics.
Topics: Animals; Computational Biology; Coumarins; Liver; Protective Agents; Protein Interaction Mapping; Protein Interaction Maps; Proteomics; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice.
Topics: Adaptor Proteins, Vesicular Transport; Alanine Transaminase; Animals; Artemisia; Coumarins; Galactosamine; Hepatocytes; Interferon-beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver Failure, Acute; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Phosphorylation; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2013 |
Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-alpha; Coumarins; Down-Regulation; Fagaceae; Mice; Phosphorylation; Plant Extracts; PPAR gamma; Triglycerides | 2013 |
7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.
Topics: Acetates; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatography, High Pressure Liquid; Coumarins; Fruit; Heptanes; Heracleum; Humans; Laryngeal Neoplasms; Methanol; Plant Extracts; Solvents; Umbelliferones; Water | 2013 |
Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Colitis; Colon; Coumarins; Esculin; Glutathione; Inflammation; Inflammatory Bowel Diseases; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Phytotherapy; Picrates; Plant Extracts; Rats; Rats, Wistar; Umbelliferones | 2014 |
Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity.
Topics: Animals; Antineoplastic Agents; Artemisia; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Coumarins; Cyclin D1; G1 Phase; HCT116 Cells; HeLa Cells; Hep G2 Cells; HT29 Cells; Humans; Inhibitor of Apoptosis Proteins; Interleukin-6; Janus Kinase 2; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Survivin; Transcription, Genetic | 2013 |
Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms.
Topics: Ceramides; Coumarins; Drugs, Chinese Herbal; Eleutherococcus; Fruit; Glucosides; Lignans; Nuclear Magnetic Resonance, Biomolecular; Rutin; Stereoisomerism; Stigmasterol | 2014 |
Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties.
Topics: Antineoplastic Agents, Phytogenic; Coumarins; Drug Screening Assays, Antitumor; Female; Ferula; Humans; Iran; K562 Cells; Lactones; MCF-7 Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Sesquiterpenes | 2014 |
[Study on distributed patterns of scoparone and ayapin in Dendrobium species from Yunnan].
Topics: China; Chromatography, High Pressure Liquid; Coumarins; Dendrobium; Drugs, Chinese Herbal; Phytoalexins; Sesquiterpenes | 2013 |
[Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats].
Topics: Animals; Coumarins; Disease Models, Animal; Immunoglobulin E; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Th1-Th2 Balance | 2013 |
[Study on quality standard of Chimonanthus nitens leaf].
Topics: Calycanthaceae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Coumarins; Drugs, Chinese Herbal; Plant Leaves; Quality Control; Reproducibility of Results; Rutin; Scopoletin | 2013 |
Protective effects of scoparone against lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Artemisia; Cells, Cultured; Coumarins; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Lipopolysaccharides; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Peroxidase; Pulmonary Edema; Signal Transduction; Toll-Like Receptor 4 | 2014 |
Effectiveness of phenolic compounds against citrus green mould.
Topics: Citrus; Coumarins; Fruit; Fungicides, Industrial; Microbial Sensitivity Tests; Penicillium; Phenols; Plant Diseases; Quercetin; Scopoletin | 2014 |
Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Coumarins; Ethanol; Liver; Liver Diseases, Alcoholic; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Protective Agents; Rats | 2014 |
Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging.
Topics: Acid Phosphatase; Animals; Bone Remodeling; Catalase; Cathepsin K; Cell Differentiation; Cell Line, Tumor; Coumarins; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NFATC Transcription Factors; Osteoclasts; Oxidative Phosphorylation; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-fos; RANK Ligand; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tartrate-Resistant Acid Phosphatase; TNF Receptor-Associated Factor 6; Up-Regulation | 2015 |
Involvement of an extracellular fungus laccase in the flavonoid metabolism in Citrus fruits inoculated with Alternaria alternata.
Topics: Alternaria; Citrus; Coumarins; Flavonoids; Fruit; Laccase; Plant Diseases | 2015 |
Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells.
Topics: Active Transport, Cell Nucleus; Animals; Becaplermin; Biomarkers; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Coumarins; Gene Expression Regulation; Hep G2 Cells; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proto-Oncogene Proteins c-sis; Rats; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic | 2015 |
Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.
Topics: Alanine; Animals; Anti-Ulcer Agents; Artemisia; Coumarins; Ethanol; Hydrochloric Acid; Indomethacin; Male; Phytotherapy; Plant Extracts; Quinolones; Rats, Sprague-Dawley; Stomach Ulcer | 2015 |
Regeneration-Based Quantification of Coumarins (Scopoletin and Scoparone) in Abutilon indicum In Vitro Cultures.
Topics: Chromatography, High Pressure Liquid; Coumarins; Cytokinins; Malvaceae; Plant Somatic Embryogenesis Techniques; Regeneration; Scopoletin; Seeds; Tissue Culture Techniques | 2016 |
Scoparone affects lipid metabolism in primary hepatocytes using lipidomics.
Topics: Animals; Anti-Arrhythmia Agents; Biomarkers; Cells, Cultured; Coumarins; Hepatocytes; Lipid Metabolism; Lipids; Male; Mice; Mice, Inbred ICR | 2016 |
Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone.
Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Artificial Gene Fusion; Cells, Cultured; Coumarins; Flow Cytometry; Genes, Reporter; Green Fluorescent Proteins; HIV-1; Humans; Hymecromone; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Leukocytes, Mononuclear; Proviruses; Virus Activation | 2016 |
Study on quality standards for Chimonanthus nitens.
Topics: Calibration; Calycanthaceae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Coumarins; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Plant Extracts; Quality Control; Reference Standards; Reproducibility of Results; Rutin; Scopoletin; Sensitivity and Specificity | 2016 |
Hybrid molecularly imprinted polymers modified by deep eutectic solvents and ionic liquids with three templates for the rapid simultaneous purification of rutin, scoparone, and quercetin from Herba Artemisiae Scopariae.
Topics: Artemisia; Coumarins; Ionic Liquids; Molecular Imprinting; Polymers; Quercetin; Rutin; Solid Phase Extraction; Solvents | 2016 |
Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats.
Topics: Animals; Biomarkers; Cell Proliferation; Cell Separation; Cells, Cultured; Coumarins; Epithelial-Mesenchymal Transition; Fibrosis; Male; Malondialdehyde; Oxidative Stress; Pancreas; Pancreatic Stellate Cells; Pancreatitis, Chronic; Protective Agents; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Superoxide Dismutase; Transforming Growth Factor beta | 2016 |
Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Coumarins; Disease Models, Animal; Humans; Liver Diseases; Metabolic Networks and Pathways; Metabolome; Mice, Inbred BALB C; Multivariate Analysis; Syndrome; Tandem Mass Spectrometry | 2016 |
Using Light Microscopy and Liquid Chromatography Tandem Mass Spectrometry for Qualitative and Quantitative Control of a Combined Three-Herb Formulation in Different Preparations.
Topics: Anthraquinones; Chromatography, High Pressure Liquid; Coumarins; Drugs, Chinese Herbal; Iridoids; Microscopy; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells.
Topics: Cell Line; Coumarins; Humans; Inflammation; Interferon Regulatory Factor-3; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases | 2016 |
Two new coumarins from the bark of Streblus indicus (Bur.) Corner.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Coumarins; Furans; Humans; Moraceae; Plant Bark; Staphylococcus aureus | 2017 |
Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-β/Smad signaling pathway.
Topics: Actins; Animals; Cell Line; Cell Proliferation; Collagen Type I; Coumarins; Hepatic Stellate Cells; Liver Cirrhosis; NADPH Oxidases; Phosphorylation; Rats; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2017 |
Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release.
Topics: Adult; Carbon-13 Magnetic Resonance Spectroscopy; Citrus; Coumarins; Fruit; Humans; Neutrophils; Pancreatic Elastase; Plant Extracts; Proton Magnetic Resonance Spectroscopy; Superoxides; Young Adult | 2017 |
Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Demethylation; Female; Humans; Male; Mice; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Rabbits; Rats; Scopoletin; Swine | 2018 |
Scoparone attenuates high glucose-induced extracellular matrix accumulation in rat mesangial cells.
Topics: Animals; Cell Line; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Extracellular Matrix; Gene Expression Regulation; Glucose; Mesangial Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidase 2; NADPH Oxidase 4; Rats; Reactive Oxygen Species; Signal Transduction | 2017 |
6,7-dimethoxy-coumarin as a probe of hydration dynamics in biologically relevant systems.
Topics: Coumarins; Dioctyl Sulfosuccinic Acid; Fluorescent Dyes; Iodides; Micelles; Spectrometry, Fluorescence; Water | 2018 |
Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice.
Topics: Acute Disease; Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Coumarins; Cytokines; Enzyme Activation; Inflammation; Inflammation Mediators; Lipopolysaccharides; Male; Mice, Inbred C57BL; Neurons; NF-kappa B; Phosphatidylinositol 3-Kinases; Pilocarpine; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Seizures; Toll-Like Receptor 4 | 2018 |
Protective effects of scoparone against ischemia‑reperfusion‑induced myocardial injury.
Topics: Animals; Apoptosis; Cell Survival; Coumarins; Creatine Kinase; Glucose; Malondialdehyde; Membrane Potential, Mitochondrial; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Oxygen; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2018 |
Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Artemisia; Cardiomyopathies; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Coumarins; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Myocardium; Myofibroblasts; Phytotherapy; Rats; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2018 |
Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway.
Topics: ADAMTS Proteins; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Coumarins; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interleukin-1beta; Matrix Metalloproteinases, Secreted; Middle Aged; NF-kappa B; Osteoarthritis, Knee; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2018 |
Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method.
Topics: Animals; Anthraquinones; Chromatography, Liquid; Coumarins; Drug Evaluation, Preclinical; Herbal Medicine; Iridoids; Male; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2018 |
Anti-inflammatory activity of coumarins isolated from
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Male; Mice, Inbred ICR; Molecular Structure; Plant Components, Aerial; Plant Extracts; Structure-Activity Relationship; Tagetes; Tetradecanoylphorbol Acetate | 2020 |
Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasia.
Topics: Animals; Becaplermin; Cell Movement; Cell Proliferation; Coumarins; Fagaceae; Humans; Hyperplasia; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Nuts; Plant Extracts; Rats; Rats, Sprague-Dawley | 2019 |
Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Coumarins; Fibrosis; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages.
Topics: Animals; Autophagy; Cholagogues and Choleretics; Coumarins; Dose-Response Relationship, Drug; Inflammation; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RAW 264.7 Cells; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Simultaneous separation and concentration of neutral analytes by cyclodextrin assisted sweeping-micellar electrokinetic chromatography.
Topics: Benzyl Compounds; Bibenzyls; Chromatography, Micellar Electrokinetic Capillary; Coumarins; Cyclodextrins; Dendrobium; Flavanones; Micelles; Molecular Structure; Phenol | 2020 |
Lipid-Lowering Effects and Intestinal Transport of Polyphenol Extract from Digested Buckwheat in Caco-2/HepG2 Coculture Models.
Topics: Alanine Transaminase; Biological Transport; Caco-2 Cells; Cholesterol; Cholesterol, LDL; Coculture Techniques; Coumaric Acids; Coumarins; Digestion; Fagopyrum; Hep G2 Cells; Humans; Intestinal Absorption; Plant Extracts; Polyphenols; Quercetin; Rutin; Transaminases; Triglycerides | 2020 |
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Topics: Angiotensin II; Animals; Antioxidants; Biomarkers; Biopsy; Blood Pressure; Cardiomegaly; Collagen; Coumarins; Disease Management; Disease Models, Animal; Disease Susceptibility; Echocardiography; Fibroblasts; Immunohistochemistry; Male; Mice; Myocytes, Cardiac; Oxidative Stress; Rats | 2021 |
Insight into the mechanism of action of scoparone inhibiting egg development of Tetranychus cinnabarinus Boisduval.
Topics: Acaricides; Animals; Cloning, Molecular; Coumarins; Gene Expression Regulation; Ovum; Phylogeny; Tetranychidae; Vasodilator Agents; Vitellogenins | 2021 |
Neuropsychopharmacological profiling of scoparone in mice.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Biological Availability; Brain; Cognition; Coumarins; Endocannabinoids; Ethanolamines; Glycerides; Infusions, Parenteral; Lipid Metabolism; Male; Maze Learning; Mice; Prostaglandins | 2022 |
High value-added application of a renewable bioresource as acaricide: Investigation the mechanism of action of scoparone against
Topics: Acaricides; Animals; Calmodulin; Coumarins; Mites; Tetranychidae | 2022 |
Effects of Scoparone on differentiation, adhesion, migration, autophagy and mineralization through the osteogenic signalling pathways.
Topics: Autophagy; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit; Coumarins; Osteoblasts; Osteogenesis | 2022 |
Effects of scoparone on non-alcoholic fatty liver disease revealed by RNA sequencing.
Topics: Animals; Coumarins; Fatty Acids; Male; Mice; Non-alcoholic Fatty Liver Disease; Sequence Analysis, RNA; Transaminases; Triglycerides | 2022 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Mice; Phenobarbital; Seizures; Valproic Acid | 2023 |
Identification of Scoparone from Chinese Olive Fruit as a Modulator of Macrophage Polarization.
Topics: Animals; Anti-Inflammatory Agents; Coumarins; Fruit; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2023 |
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy/D-galactose Alzheimer's disease rat model.
Topics: Alzheimer Disease; Animals; Coumarins; Female; Galactose; Humans; Inflammasomes; Microglia; Myeloid Differentiation Factor 88; Neuroinflammatory Diseases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Ovariectomy; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4 | 2023 |