sclareolide and ambrox

sclareolide has been researched along with ambrox* in 3 studies

Reviews

1 review(s) available for sclareolide and ambrox

Article	Year
Isolation, chemical, and biotransformation routes of labdane-type diterpenes. Chemical reviews, 2011, Aug-10, Volume: 111, Issue:8 Topics: Abietanes; Biotransformation; Carboxylic Acids; Diterpenes; Furans; Naphthalenes; Polycyclic Sesquiterpenes; Terpenes; Tetrahydronaphthalenes	2011

Other Studies

2 other study(ies) available for sclareolide and ambrox

Article	Year
Biohydroxylation of (-)-ambrox®, (-)-sclareol, and (+)-sclareolide by whole cells of Brazilian marine-derived fungi. Marine biotechnology (New York, N.Y.), 2015, Volume: 17, Issue:2 A screening was performed using nine marine-derived fungi as biocatalysts and the natural products (-)-ambrox® (1), (-)-sclareol (2), and (+)-sclareolide (3) in order to select the microorganisms able to catalyze the biooxidation of these compounds. It was observed that only the Aspergillus sydowii CBMAI 934, Botryosphaeria sp., Eutypella sp., and Xylaria sp. presented active oxidoreductases and catalyzed the regioselective hydroxylation in the natural products. The hydroxylated metabolites obtained were 1β-hydroxy-ambrox (1a) (14%, A. sydowii CBMAI 934); 3β-hydroxy-ambrox (1b) (17%, Botryosphaeria sp.; 11%, Eutypella sp.); 3β-hydroxy-sclareol (2a) (31%, Xylaria sp.; 69%, Botryosphaeria sp.; 55%, Eutypella sp.); 18-hydroxy-sclareol (2b) (10%, Xylaria sp.); and 3β-hydroxy-sclareolide (3a) (34%, Botryosphaeria sp.; 7%, Eutypella sp.). This is the first report of biohydroxylation of (-)-ambrox® (1), (-)-sclareol (2), and (+)-sclareolide (3) by whole mycelia of marine-derived fungi. Topics: Animals; Aspergillus; Atlantic Ocean; Biological Products; Biotransformation; Brazil; Catalysis; Diterpenes; Furans; Hydroxylation; Molecular Structure; Naphthalenes; Oxidation-Reduction; Penicillium; Porifera	2015
Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products. Pakistan journal of pharmaceutical sciences, 2007, Volume: 20, Issue:2 The aim of this study was to investigate the antibacterial and the cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and of some natural products (sclareol, sclareolide and ambrox). The antibacterial and the cytotoxic activity were determined by the dilution method. Sclareolide, ambrox and sclareol demonstrated a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. The acetonic extract of the flowers of Salvia sclarea has a significant cytotoxic activity against Hep-2 cells. Topics: Acetone; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Flowers; Furans; Humans; Inhibitory Concentration 50; Liver Neoplasms; Microbial Sensitivity Tests; Naphthalenes; Plant Extracts; Pseudomonas aeruginosa; Salvia; Solvents; Staphylococcus aureus	2007

Article

Year

Biohydroxylation of (-)-ambrox®, (-)-sclareol, and (+)-sclareolide by whole cells of Brazilian marine-derived fungi.

Marine biotechnology (New York, N.Y.), 2015, Volume: 17, Issue:2

A screening was performed using nine marine-derived fungi as biocatalysts and the natural products (-)-ambrox® (1), (-)-sclareol (2), and (+)-sclareolide (3) in order to select the microorganisms able to catalyze the biooxidation of these compounds. It was observed that only the Aspergillus sydowii CBMAI 934, Botryosphaeria sp., Eutypella sp., and Xylaria sp. presented active oxidoreductases and catalyzed the regioselective hydroxylation in the natural products. The hydroxylated metabolites obtained were 1β-hydroxy-ambrox (1a) (14%, A. sydowii CBMAI 934); 3β-hydroxy-ambrox (1b) (17%, Botryosphaeria sp.; 11%, Eutypella sp.); 3β-hydroxy-sclareol (2a) (31%, Xylaria sp.; 69%, Botryosphaeria sp.; 55%, Eutypella sp.); 18-hydroxy-sclareol (2b) (10%, Xylaria sp.); and 3β-hydroxy-sclareolide (3a) (34%, Botryosphaeria sp.; 7%, Eutypella sp.). This is the first report of biohydroxylation of (-)-ambrox® (1), (-)-sclareol (2), and (+)-sclareolide (3) by whole mycelia of marine-derived fungi.

Topics: Animals; Aspergillus; Atlantic Ocean; Biological Products; Biotransformation; Brazil; Catalysis; Diterpenes; Furans; Hydroxylation; Molecular Structure; Naphthalenes; Oxidation-Reduction; Penicillium; Porifera

2015

Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products.

Pakistan journal of pharmaceutical sciences, 2007, Volume: 20, Issue:2

The aim of this study was to investigate the antibacterial and the cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and of some natural products (sclareol, sclareolide and ambrox). The antibacterial and the cytotoxic activity were determined by the dilution method. Sclareolide, ambrox and sclareol demonstrated a good antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27950, Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212. The acetonic extract of the flowers of Salvia sclarea has a significant cytotoxic activity against Hep-2 cells.

Topics: Acetone; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Flowers; Furans; Humans; Inhibitory Concentration 50; Liver Neoplasms; Microbial Sensitivity Tests; Naphthalenes; Plant Extracts; Pseudomonas aeruginosa; Salvia; Solvents; Staphylococcus aureus

2007

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sclareolide and ambrox

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