Compounds > schizandrol b
Page last updated: 2024-08-25

schizandrol b and lignans

schizandrol b has been researched along with lignans in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-199019 (17.27)18.7374
1990's18 (16.36)18.2507
2000's12 (10.91)29.6817
2010's49 (44.55)24.3611
2020's12 (10.91)2.80

Authors

AuthorsStudies
Ikeya, Y; Kobayashi, H; Taguchi, H; Yosioka, I1
He, J; Liu, Y; Sha, D; Wang, L; Zheng, S1
Aburada, M; Hosoya, E; Kinoshita, H; Kubo, S; Matsui-Yuasa, I; Mizoguchi, Y; Morisawa, S; Ohkura, Y; Otani, S; Takeda, S1
Aburada, M; Ikeya, Y; Iwasaki, M; Mitsuhashi, H; Nakagawa, S; Takeuchi, M; Takido, M; Yasukawa, K1
Aburada, M; Hosoya, E; Ikeya, Y; Koguchi, S; Matsuzaki, T; Matsuzaki, Y; Mitsuhashi, H; Oyama, T; Sasaki, H; Takeda, S1
Aburada, M; Funo, S; Hosoya, E; Koguchi, S; Matsuzaki, T; Matsuzaki, Y; Ono, H; Oyama, T; Takeda, S1
Ichikawa, Y; Kawada, N; Mizoguchi, Y; Tsutsui, H1
Fujii, Y; Miyamoto, K; Nomura, M; Ohtaki, Y; Sakai, R; Sanae, F; Sudo, K; Takeda, S; Wakusawa, S1
Aburada, M; Ishibashi, E; Koguchi, S; Matsuzaki, Y; Oyama, T; Takeda, S; Wakui, Y1
Kobayashi, K; Mizoguchi, Y; Morisawa, S; Shin, T1
Aburada, M; Hosoya, E; Mizoguchi, Y; Morisawa, S; Ohkura, Y; Takeda, S1
Hosoya, E; Ikeya, Y; Matsuzaki, T; Matsuzaki, Y; Mitsuhashi, H; Sasaki, H1
Song, WZ; Tong, YY; Wang, K1
Liu, GT1
Aburada, M; Aoki, M; Koda, A; Nagai, H; Ono, Y; Sengoku, T; Shimazawa, T; Teshima, K; Yakuo, I1
Aburada, M; Arai, I; Funo, S; Hasegawa, M; Hosoya, E; Kase, Y; Ohkura, Y; Sekiguchi, Y; Takeda, S; Tatsugi, A1
Aburada, M; Hosoya, E; Ikeya, Y; Matsuzaki, T; Mitsuhashi, H; Sasaki, H; Taguchi, H1
Aburada, M; Arai, I; Hasegawa, M; Hosoya, E; Takeda, S; Tatsugi, A1
Liu, GT; Wei, HL1
Li, Y; Liu, GT1
Higashimori, T; Kobayashi, K; Miyajima, K; Mizoguchi, Y; Morisawa, S; Okura, Y; Sakagami, Y; Tsutsui, H; Yamamoto, S1
Aburada, M; Kobayashi, K; Mizoguchi, Y; Morisawa, S; Ohkura, Y; Sakagami, Y; Takeda, S; Yamamoto, S1
Aburada, M; Arai, I; Hasegawa, M; Hosoya, E; Kase, Y; Ohkura, Y; Sekiguchi, Y; Sudo, K; Takeda, S1
Aburada, M; Arai, I; Fujii, Y; Funo, S; Hosoya, E; Kase, Y; Maemura, S; Ohkura, Y; Sudo, K; Takeda, S1
Aburada, M; Arai, I; Funo, S; Hasegawa, M; Hosoya, E; Kase, Y; Mizoguchi, Y; Morisawa, S; Sekiguchi, Y; Takeda, S1
Aburada, M; Harada, M; Maeda, S; Miyamoto, Y; Takeda, S1
Hikino, H; Ikeya, Y; Kiso, Y; Taguchi, H; Tohkin, M1
Cresteil, T; Le Provost, E; Lesca, P; Liu, KT1
Lesca, P; Liu, KT2
Aburada, M; Harada, M; Ikeya, Y; Maeda, S; Sudo, K; Taguchi, H; Yoshioka, I1
Aburada, M; Aizawa, T; Kajiwara, R; Kamataki, T; Kawaguchi, Y; Nagayama, S; Otaki, Y; Yokoi, T1
Aburada, M; Aizawa, T; Hida, T; Kanitani, M; Miyamoto, K; Nomura, M; Ohtaki, Y1
Aburada, M; Aizawa, T; Hida, T; Miyamoto, KI; Nakachiyama, M; Nomura, M; Ohtaki, Y; Sudo, K1
Kawasaki, H; Murawaki, Y; Yamada, S1
Aburada, M; Hiramatsu, K; Kanitani, M; Miyamoto, K; Nomura, M; Ohtaki, Y1
Kawasaki, H; Shiota, G; Yamada, S1
Cyong, JC; Furuya, M; Iijima, K; Ki, SM; Kobayashi, T1
Kim, SH; Kim, SR; Kim, YC; Koo, KA; Lee, MK; Lee, NG; Markelonis, GJ; Oh, TH; Sung, SH; Yang, JH1
Fan, G; Peng, J; Qu, L; Wu, Y; Zhou, X1
Bae, KH; Cheong, JH; Hung, TM; Jung, JW; Kim, DH; Ko, KH; Lee, S; Ryu, JH; Yoon, BH1
Chattopadhyay, A; Dey, S; Fong, WF; Shen, XL; Wan, CK; Zhu, GY1
Konishi, T; Kushida, M; Nakajima, Y; Nishida, H; Ogawa, Y; Sato, S; Tatewaki, N1
Bae, SS; Choi, YW; Kim, CD; Lee, SJ; Lee, YJ; Park, JW; Park, JY; Seo, KW; Shin, WJ; Yun, MR1
Bae, K; Hung, TM; Kang, SS; Kim, SH; Kim, YS; Lee, SM1
Huang, M; Jin, J; Liu, GT; Sun, H1
Avula, B; Choi, YW; Khan, IA; Khan, SI; Madgula, VL; Pullela, SV; Walker, LA1
Bae, SS; Choi, YW; Han, J; Kim, CD; Lee, YJ; Park, JY; Shin, HK1
Han, L; He, XX; Pan, Y; Shi, L; Yang, XO; Zhao, YQ1
Choi, IW; Choi, YH; Choi, YW; Hwang, WD; Jeong, YK; Jin, CY; Kim, GY; Kim, JH; Kim, SG; Kim, SK; Lee, YJ; Park, C; Park, DJ1
Fong, DW; Tse, AK; Wan, CK; Wang, H; Yu, ZL; Zhu, GY1
Gao, Q; Li, X; Luo, H; Weng, W; Xiao, F1
Bi, H; Hu, J; Huang, M; Huang, Z; Jin, J; Zhao, L; Zhong, G1
Choi, YW; Kim, GD; Kim, HY; Kim, IK; Seok, YM; Takuwa, Y1
Chen, Q; Cheng, NN; Li, YL; Wang, YM; Wu, YJ1
Bak, YO; Choi, BR; Jeon, JH; Kim, CY; Kim, HK; Lee, HJ; Lee, SW; Park, JK; Zhao, C1
Guan, M; Li, T; Liu, Y; Sheng, Y; Wang, Y; Yuan, G1
Ekiert, H; Szopa, A1
Hwang, D; Hyun, J; Lee, Y; Lee, YH; Lim, Y; Park, JC; Shin, SY; Yong, Y1
Kohda, H; Namera, A; Ozaki, M1
Choi, YW; Kang, JS; Kim, SG; Kim, YH; Lee, SJ; Park, DJ; Park, SY; Ryu, EY; Seetharaman, R1
Aburada, M; Shimada, T; Teraoka, R1
Jin Lee, S; Kim, CD; Ung Bae, J; Whan Choi, Y; Whan Hong, K; Won Seo, K; Wook Yun, J; Youn Park, S; Young Park, J1
Alexander, JS; Wang, Y1
Saiki, I; Sakurai, H; Shin, MS; Waiwut, P; Yokoyama, S1
Han, Y; Sun, H; Wang, X; Wei, W; Wu, F; Zhang, A1
Choi, YH; Hong, JT; Hwang, DY; Hwang, IS; Kang, BC; Kim, JE; Kwak, MH; Lee, YJ1
Bi, K; Chen, X; Fan, R; Geng, L; He, B; Jia, Y; Li, Q; Su, D; Wei, B; Zhao, L1
Jia, X; Lai, H; Liu, H; Liu, J; Qi, Y; Song, J; Wu, C; Xiao, P; Zhang, B; Zhang, J; Zhang, Z1
Bi, HC; Chen, X; Huang, M; Li, JL; Qin, XL; Wang, CX; Wang, XD; Wang, Y; Xue, XP; Yang, H; Zhong, GP1
Hu, D; Lian, G; Wang, C; Wang, X; Wu, C; Yang, J; Yin, J; Zhang, L; Zhao, S1
Bae, YS; Choi, YW; Ko, MJ; Lee, SJ; Park, SY1
Choi, IS; Han, NR; Jeong, HJ; Kim, HM; Kim, KY1
Hu, XL; Liu, ZQ; Pi, ZF; Song, FR; Yu, XL1
Chen, L; Chen, T; Ding, P; Li, XK; Song, X; Wang, B1
Cheng, Q; Ji, B; Liu, J; Wang, O; Wang, Y; Zhao, L; Zhou, F1
Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Choi, YW; Kim, CD; Lee, SJ; Park, SY; Ye, BH1
Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H1
Liu, CH; Liu, S; Tao, YY; Yang, T; Zheng, TH1
An, LP; Chen, M; Dou, ZH; Ju, YF; Luo, L; Miao, YX; Qiao, J1
Ekiert, H; Kisiel, W; Szewczyk, A; Szopa, A1
An, LB; Cui, L; Dong, PP; Fang, ZZ; Gonzalez, FJ; Li, WT; Song, JH; Sun, XY; Wang, LX; Wu, X; Zhang, YY; Zhao, DW1
Dai, ZR; Ge, GB; He, YQ; Hu, LH; Ning, J; Wang, P; Wu, JJ; Yang, L1
Bi, HC; Chen, P; Fan, XM; Huang, M; Jiang, YM; Tan, HS; Wang, Y; Yu, T; Zeng, H1
Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Li, D; Liu, A; Liu, P; Ma, X; Xie, W; Zeng, H1
Chae, HS; Chin, YW; Kim, YM; Nhoek, P; Pel, P; Yeo, W1
Bradbury, EJ; Brown, CF; Lyles, JT; Nelson, K; Pierce, ST; Quave, CL; Tyler, P1
Chae, HJ; Jang, JB; Jeong, HJ; Kim, HM; Kim, KY; Kim, MH; Lee, JM; Nam, SY; Rah, SY1
Cheon, SM; Cho, HY; Ham, SH; Kim, SJ; Ko, SM; Kwon, YD; Lee, YB; Shin, H1
Chen, L; Chen, W; Feng, G; Gao, S; Yin, J; Zhai, J; Zhang, F1
Bi, H; Chen, Y; Fan, X; Guan, L; Huang, M; Jiang, F; Li, D; Li, X; Sun, J; Xu, L; Zeng, X; Zhang, H; Zhou, Y1
Han, SH; Jeong, SH; Kim, JS; Yi, HK1
Bi, HC; Chen, X; Duan, WH; Huang, M; Qin, XL; Wang, HF; Wang, Y1
Cheng, X; Ding, XY; Ji, JD; Lu, TL; Mao, CQ; Su, LL; Wang, LJ; Zhang, J1
Fang, L; Guo, X; Han, X; Leng, A; Li, D; Peng, J; Qi, Y; Sun, C; Wang, R; Yin, L1
Du, Z; Fu, Q; Hu, CM; Hu, RX; Yang, K; Zhang, X1
Atsumi, T; Makino, T; Ohtsuka, I; Yokogawa, T; Yokoyama, Y1
Han, SH; Kim, JE; Takanche, JS; Yi, HK1
Han, YH; Hong, SH; Jeon, HD; Kee, JY; Mun, JG; Park, J1
Ai, X; Dong, J; Han, G; Liu, Y; Song, J; Wang, Z; Yang, Q; Zhong, L1
Ahn, SJ; In, S; Kim, E; Kim, HJ; Lee, A; Min, SS1
Lee, KG; Park, M1
Chang, WT; Wu, SN1
Bi, HC; Chen, PP; Chen, YX; Fan, SC; Gao, Y; Huang, M; Jiang, YM; Jiao, TY; Tian, JN; Yang, X; Yao, XP; Zhao, YY; Zhou, YY1
Han, YH; Hong, SH; Kee, JY1
Bu, F; He, Q; Li, M; Lin, HS; Lin, J; Mak, WY; Tang, Z; Wang, Q; Xiang, X; Zhu, X; Zhuang, X1
Bi, H; Cai, C; Huang, M; Li, H; Li, X; Liang, H; Su, H; Tian, J; Wang, X; Yang, X1
Bi, K; Li, Q; Li, S; Xu, H; Yang, P; Zhang, Q; Zhang, Y1
Chen, J; Chen, M; Huang, X; Liu, J; Shangguan, M; Wang, T; Wu, S; Yang, Z; Zhang, C; Zhao, S1

Other Studies

110 other study(ies) available for schizandrol b and lignans

ArticleYear
The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin.
    Chemical & pharmaceutical bulletin, 1979, Volume: 27, Issue:6

    Topics: Chemical Phenomena; Chemistry; Cyclooctanes; Cycloparaffins; Dioxoles; Lignans; Molecular Conformation; Plant Extracts; Plants, Medicinal; Polycyclic Compounds

1979
[Thin layer chromatographic studies on radix Ginseng, fructus Schisandrae and radix Salviae miltiorrhizae in yixinfumai granules].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1992, Volume: 17, Issue:4

    Topics: Chromatography, Thin Layer; Cyclooctanes; Dioxoles; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Lignans; Panax; Plants, Medicinal; Polycyclic Compounds; Saponins

1992
Effect of Gomisin A (TJN-101) on liver regeneration.
    Planta medica, 1992, Volume: 58, Issue:6

    Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Liver Regeneration; Male; Mitotic Index; Polyamines; Polycyclic Compounds; Rats; Rats, Wistar

1992
Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
    Oncology, 1992, Volume: 49, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Inflammation; Lignans; Mice; Mice, Inbred ICR; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate

1992
[Studies on the metabolic fate of gomisin A (TJN-101). I. Absorption in rats].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:9

    Topics: Administration, Oral; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Injections, Intravenous; Intestinal Absorption; Lignans; Male; Polycyclic Compounds; Protein Binding; Rats; Rats, Inbred Strains

1991
[Studies on the metabolic fate of gomisin A (TJN-101). II. Absorption and excretion in CCl4 treated rats].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:9

    Topics: Administration, Oral; Animals; Blood Proteins; Carbon Tetrachloride Poisoning; Cyclooctanes; Dioxoles; Injections, Intravenous; Lignans; Male; Polycyclic Compounds; Protein Binding; Rats; Rats, Inbred Strains

1991
Effect of gomisin A in the prevention of acute hepatic failure induction.
    Planta medica, 1991, Volume: 57, Issue:4

    Topics: Animals; Cyclooctanes; Diet; Dioxoles; Interleukin-1; Lignans; Liver Diseases; Male; Polycyclic Compounds; Propionibacterium acnes; Rats; Rats, Inbred Strains; Spleen; Transaminases

1991
Effects of gomisin A on hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Cyclooctanes; Dioxoles; Lignans; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Molecular Structure; Organ Size; Phenobarbital; Polycyclic Compounds; Rats; Rats, Inbred Strains

1991
[Determination of gomisin A (TJN-101) and its metabolite in rat serum by gas chromatography-mass spectrometry].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:10

    Topics: Animals; Cyclooctanes; Dioxoles; Gas Chromatography-Mass Spectrometry; Lignans; Male; Monitoring, Physiologic; Polycyclic Compounds; Rats; Rats, Inbred Strains

1991
Effect of gomisin A in an immunologically-induced acute hepatic failure model.
    Planta medica, 1991, Volume: 57, Issue:1

    Topics: Animals; Cyclooctanes; Dioxoles; Guinea Pigs; Lignans; Liver Diseases; Male; Polycyclic Compounds; Survival Rate; Transaminases

1991
Effect of gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:2

    Topics: Animals; Arachidonic Acids; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Exudates and Transudates; Leukotriene B4; Lignans; Lipoxygenase; Macrophages; Male; Phospholipases A; Phospholipases A2; Polycyclic Compounds; Rats; Rats, Inbred Strains

1990
Studies on the metabolism of gomisin A (TJN-101). II. Structure determination of biliary and urinary metabolites in rat.
    Chemical & pharmaceutical bulletin, 1990, Volume: 38, Issue:1

    Topics: Animals; Bile; Cyclooctanes; Dioxoles; Lignans; Male; Polycyclic Compounds; Rats; Rats, Inbred Strains

1990
[Determination of the active ingredients in Chinese drug wuweizi (Schisandra chinensis) by TLC-densitometry].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1990, Volume: 25, Issue:1

    Topics: Chromatography, Thin Layer; Cyclooctanes; Densitometry; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds

1990
Pharmacological actions and clinical use of fructus schizandrae.
    Chinese medical journal, 1989, Volume: 102, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Drugs, Chinese Herbal; Hepatitis B; Humans; Lignans; Lipid Peroxidation; Mice; Microsomes, Liver; Polycyclic Compounds; Rats

1989
The effect of gomisin A on immunologic liver injury in mice.
    Planta medica, 1989, Volume: 55, Issue:1

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cyclooctanes; Cyclophosphamide; Dioxoles; Lignans; Liver Diseases; Male; Mice; Mice, Inbred DBA; Polycyclic Compounds

1989
[Effects of TJN-101, a lignan compound isolated from Schisandra fruits, on liver fibrosis and on liver regeneration after partial hepatectomy in rats with chronic liver injury induced by CCl4].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987, Volume: 90, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Carbon Tetrachloride Poisoning; Cyclooctanes; Dioxoles; Hepatectomy; Lignans; Liver Cirrhosis, Experimental; Liver Regeneration; Male; Plant Extracts; Polycyclic Compounds; Rats; Rats, Inbred Strains

1987
Studies on the metabolism of gomisin A (TJN-101). I. Oxidative products of gomisin A formed by rat liver S9 mix.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:6

    Topics: Animals; Cyclooctanes; Dioxoles; In Vitro Techniques; Lignans; Liver; Male; Oxidation-Reduction; Polycyclic Compounds; Rats; Rats, Inbred Strains; Subcellular Fractions

1988
[Effect of gomisin A (TJN-101), a lignan compound isolated from Schisandra fruits, on liver function in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1988, Volume: 91, Issue:4

    Topics: Animals; Bile; Bile Pigments; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Liver; Liver Circulation; Male; Polycyclic Compounds; Rats; Rats, Inbred Strains

1988
[Protection by fructus Schizandrae against acetaminophen hepatotoxicity in mice].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1987, Volume: 22, Issue:9

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione; Lignans; Liver; Male; Mice; Microsomes, Liver; Polycyclic Compounds

1987
[Effects of schizandrins and diphenyl dimethyl bicarboxylate on enzymes of liver smooth and rough endoplasmic reticula in rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:6

    Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Endoplasmic Reticulum; Lignans; Liver; Male; Polycyclic Compounds; Rats; Rats, Inbred Strains

1987
[The protective effect of gomisin A on experimentally induced acute hepatic injury].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987, Volume: 84, Issue:3

    Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Guinea Pigs; Lignans; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Rats

1987
Inhibitory effect of TJN-101 ((+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy -6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on immunologically induced liver injuries.
    Japanese journal of pharmacology, 1987, Volume: 44, Issue:2

    Topics: Alanine Transaminase; Animals; Antibody-Dependent Cell Cytotoxicity; Aspartate Aminotransferases; Cyclooctanes; Dioxoles; Guinea Pigs; Lignans; Lipopolysaccharides; Liver Diseases; Macrophage Activation; Male; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Proteins

1987
[Pharmacological studies on antihepatotoxic action of (+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy++ + -6,7-dimethyl-10,11-methylenedioxy-6-dibenzo[a,c] cyclooctenol (TJN-101), a lignan component of Schisandra fruits. Influences of resolven
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1987, Volume: 107, Issue:7

    Topics: Animals; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Lignans; Liver; Male; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Polysorbates; Rats; Rats, Inbred Strains; Solvents; Transaminases

1987
[Effects of gomisin A, a lignan component of Schizandra fruits, on experimental liver injuries and liver microsomal drug-metabolizing enzymes].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 87, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Ethionine; Galactosamine; Lignans; Liver Diseases; Male; Microsomes, Liver; Mixed Function Oxygenases; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sleep

1986
[Effects of TJN-101 ((+)-(6s,7s,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7 -dimethyl-10,11-methylenedioxy-6-dibenzo [a,c] cyclooctenol) on liver regeneration after partial hepatectomy, and on regional hepatic blood flow and fine structure of the
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:4

    Topics: Animals; Cyclooctanes; Dioxoles; Lignans; Liver; Liver Circulation; Liver Regeneration; Male; Polycyclic Compounds; Rats; Rats, Inbred Strains

1986
Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.
    Japanese journal of pharmacology, 1985, Volume: 38, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Galactosamine; Indocyanine Green; Lignans; Liver; Liver Function Tests; Male; Orotic Acid; Polycyclic Compounds; Rats; Rats, Inbred Strains

1985
Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A.
    Planta medica, 1985, Issue:4

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Inbred Strains

1985
Specific evidence that schizandrins induce a phenobarbital-like cytochrome P-450 form separated from rat liver.
    Biochemical and biophysical research communications, 1981, Dec-31, Volume: 103, Issue:4

    Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxolanes; Dioxoles; Hydrocarbons, Chlorinated; Immunodiffusion; Lignans; Male; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats; Rats, Inbred Strains

1981
Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.
    Chemico-biological interactions, 1982, Volume: 39, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; In Vitro Techniques; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Microsomes, Liver; Mutagens; NADP; Oxidation-Reduction; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains

1982
Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids.
    Chemico-biological interactions, 1982, Jul-15, Volume: 41, Issue:1

    Topics: Animals; Carbon Tetrachloride; China; Cyclooctanes; Dioxoles; Lignans; Lipid Metabolism; Lipid Peroxides; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; NADP; Oxygen Consumption; Plants, Medicinal; Polycyclic Compounds

1982
[Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1981, Volume: 101, Issue:11

    Topics: Animals; Cyclooctanes; Cycloparaffins; Dioxoles; Drug Synergism; Guinea Pigs; Hexobarbital; Lignans; Male; Methamphetamine; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains; Sleep

1981
Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)- 5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol)
    Toxicology letters, 1995, Volume: 76, Issue:1

    Topics: Animals; Autoantibodies; Autoimmune Diseases; Body Weight; Cyclooctanes; Dioxoles; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis, Animal; Lignans; Microsomes, Liver; Rats

1995
Inhibition by gomisin A, a lignan compound, of hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:6

    Topics: Animals; Cell Division; Cell Nucleus; Cyclooctanes; Diet; Dioxoles; Drugs, Chinese Herbal; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Glutathione Transferase; Immunoblotting; Immunohistochemistry; Isoenzymes; Lignans; Liver; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; Ploidies; Protein Binding; Rats

1994
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene.
    Cancer letters, 1994, Jan-15, Volume: 76, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Nucleus; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione Transferase; Isoenzymes; Lignans; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Organ Size; Phenobarbital; Ploidies; Precancerous Conditions; Rats

1994
Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats.
    Biochemical pharmacology, 1993, Sep-14, Volume: 46, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glutathione; Lignans; Lipid Peroxides; Liver; Liver Diseases; Male; Organ Size; Rats; Rats, Wistar; Time Factors

1993
Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Bile Acids and Salts; Body Weight; Carcinogens; Cyclooctanes; Deoxycholic Acid; Dioxoles; Immunohistochemistry; Lignans; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Organ Size; Phenobarbital; Rats

1995
Rapid induction of hepatocyte growth factor mRNA after administration of gomisin A, a lignan component of shizandra fruits.
    Research communications in molecular pathology and pharmacology, 1996, Volume: 94, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cyclooctanes; Dioxoles; Fruit; Gene Expression Regulation; Hepatocyte Growth Factor; Lignans; Liver; Male; Plants, Medicinal; Rats; Rats, Wistar; RNA, Messenger

1996
Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine.
    The American journal of Chinese medicine, 2000, Volume: 28, Issue:3-4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Cell Line; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Hepatitis C, Chronic; Humans; Lignans; Liver Diseases; Liver Failure; Medicine, Kampo; Mice; Middle Aged; Plant Extracts; RNA, Viral; Time Factors

2000
Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
    Journal of neuroscience research, 2004, May-01, Volume: 76, Issue:3

    Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Glutamic Acid; Intracellular Fluid; Lignans; Neurons; Neuroprotective Agents; Neurotoxins; Peroxides; Phytotherapy; Plant Extracts; Polycyclic Compounds; Rats; Schisandra

2004
Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis.
    Journal of chromatography. A, 2005, Aug-05, Volume: 1082, Issue:2

    Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds; Schisandra

2005
Gomisin A improves scopolamine-induced memory impairment in mice.
    European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3

    Topics: Acetylcholinesterase; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cognition; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Lignans; Male; Maze Learning; Memory; Mice; Mice, Inbred ICR; Scopolamine

2006
Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.
    Biochemical pharmacology, 2006, Sep-28, Volume: 72, Issue:7

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrolysis; Lignans; Prazosin; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Vanadates; Verapamil; Vinblastine

2006
Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:1

    Topics: alpha-Tocopherol; Amyloid beta-Peptides; Animals; Apoptosis; bcl-Associated Death Protein; Caspase 3; Caspase Inhibitors; Cell Survival; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Flow Cytometry; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase-1; Lignans; MAP Kinase Kinase 4; Oxidation-Reduction; PC12 Cells; Polycyclic Compounds; Rats; Time Factors

2007
Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta.
    Planta medica, 2007, Volume: 73, Issue:15

    Topics: Animals; Aorta, Thoracic; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Endothelium, Vascular; Fruit; Lignans; Male; Muscle Relaxation; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Schisandra; Vasodilator Agents

2007
Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:2

    Topics: Alanine Transaminase; Animals; Apoptosis; Caspase 3; Cyclooctanes; Dioxoles; DNA Fragmentation; Galactosamine; Glutathione; Lignans; Lipid Peroxidation; Lipopolysaccharides; Liver Failure; Male; Mice; Mice, Inbred ICR; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; Protective Agents; Tumor Necrosis Factor-alpha

2008
Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:6

    Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclooctanes; Dioxoles; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fruit; Genes, MDR; Humans; Lignans; Mice; Mice, Nude; Neoplasm Proteins; Phytotherapy; Plant Preparations; Polycyclic Compounds; Protein Kinase C; Schisandra; Xenograft Model Antitumor Assays

2008
Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:3

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Cyclooctanes; Diffusion; Dioxoles; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Lignans; Medicine, Chinese Traditional; Models, Biological; Multidrug Resistance-Associated Proteins; Permeability; Plant Extracts; Polycyclic Compounds; Schisandra

2008
Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells.
    Journal of ethnopharmacology, 2009, Sep-07, Volume: 125, Issue:2

    Topics: Calcium; Cells, Cultured; Chelating Agents; Chromones; Coronary Vessels; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Cells; Enzyme Inhibitors; Fruit; Humans; Lignans; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type III; Plant Extracts; Schisandra; Time Factors; Vasodilator Agents

2009
[Study on the chemical constituents of the fruit handles from Schizandra chinensis].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, Volume: 32, Issue:7

    Topics: Chromatography, Thin Layer; Cyclooctanes; Dioxoles; Fruit; Lignans; Magnetic Resonance Spectroscopy; Plants, Medicinal; Polycyclic Compounds; Schisandra; Sitosterols

2009
Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Cell Proliferation; Cell Survival; Cyclin D1; Cyclooctanes; Cytochromes c; Dioxoles; DNA Fragmentation; Flow Cytometry; Fruit; G1 Phase; Humans; Lignans; Mitochondria; Polycyclic Compounds; Schisandra; U937 Cells

2010
Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:8-9

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Drug Resistance, Multiple; Fruit; Glutathione; Hep G2 Cells; Herb-Drug Interactions; Humans; Inhibitory Concentration 50; Lignans; Plant Extracts; Schisandra

2010
[Research on liposoluble ingredients of Quchiling].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:1

    Topics: Allylbenzene Derivatives; Animals; Anisoles; Brain; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Gas Chromatography-Mass Spectrometry; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley

2010
Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats.
    Biopharmaceutics & drug disposition, 2010, Volume: 31, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intravenous; Lignans; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Schisandra

2010
Effects of gomisin A on vascular contraction in rat aortic rings.
    Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Cyclooctanes; Dioxoles; Indoles; Lignans; Male; Muscle Proteins; Myosin Light Chains; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Potassium Channel Blockers; Protein Kinase Inhibitors; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction; Sodium Fluoride; Vasoconstriction; Vasodilator Agents

2011
[Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:9

    Topics: Animals; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hepatocytes; Inhibitory Concentration 50; Lignans; Male; Microsomes, Liver; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schisandra

2010
The role of the lignan constituents in the effect of Schisandra chinensis fruit extract on penile erection.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:12

    Topics: Animals; Cyclooctanes; Dioxoles; Fruit; In Vitro Techniques; Lignans; Male; Muscle Relaxation; Muscle, Smooth; Penile Erection; Piperazines; Plant Extracts; Purines; Rabbits; Schisandra; Sildenafil Citrate; Sulfones

2011
Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
    Molecules (Basel, Switzerland), 2011, May-03, Volume: 16, Issue:5

    Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds

2011
Lignans in Schisandra chinensis in vitro cultures.
    Die Pharmazie, 2011, Volume: 66, Issue:8

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Lignans; Plant Extracts; Plant Leaves; Plant Shoots; Schisandra

2011
A compound isolated from Schisandra chinensis induces apoptosis.
    Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 7; Colonic Neoplasms; Cyclooctanes; Dioxoles; HCT116 Cells; Humans; Lignans; Schisandra

2011
Production of lignans in calluses of Schisandra chinensis.
    Journal of natural medicines, 2012, Volume: 66, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Indoles; Kinetin; Lignans; Schisandra

2012
Anti-inflammatory effect of heme oxygenase-1 toward Porphyromonas gingivalis lipopolysaccharide in macrophages exposed to gomisins A, G, and J.
    Journal of medicinal food, 2011, Volume: 14, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooctanes; Dioxoles; Fruit; Heme Oxygenase-1; Inflammation; Interleukin-1beta; Interleukin-6; Lignans; Lipopolysaccharides; Membrane Proteins; Mice; NF-kappa B; Plant Extracts; Polycyclic Compounds; Porphyromonas gingivalis; Schisandra; Signal Transduction; Tumor Necrosis Factor-alpha

2011
The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:2

    Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Interleukin-1beta; Lignans; Lipid Peroxidation; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha

2012
Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:9

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Blood Vessels; Cells, Cultured; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Hypertension; Lignans; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Reactive Oxygen Species; Schisandra; Vasoconstrictor Agents

2012
Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability'
    Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:9

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Cyclooctanes; Dioxoles; Hypertension; Lignans; Male; Nitric Oxide; Schisandra; Vasoconstrictor Agents

2012
Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:11

    Topics: Antineoplastic Agents; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; G1 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; Lignans; Phosphorylation; Retinoblastoma Protein; Schisandra; STAT1 Transcription Factor; Tumor Necrosis Factor-alpha

2012
Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
    Journal of separation science, 2013, Volume: 36, Issue:3

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization

2013
Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.
    International journal of molecular medicine, 2013, Volume: 31, Issue:4

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Kidney; Lignans; Liver; MAP Kinase Signaling System; Organ Size; Phosphorylation; Protective Agents; Rats; Rats, Sprague-Dawley; Schisandra

2013
Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats.
    Journal of pharmaceutical and biomedical analysis, 2013, Apr-15, Volume: 77

    Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Medicine, Chinese Traditional; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Sensitivity and Specificity; Sleep Initiation and Maintenance Disorders; Tandem Mass Spectrometry

2013
Comprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometrics.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Sep-15, Volume: 20, Issue:12

    Topics: Chromatography, High Pressure Liquid; Cluster Analysis; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Mass Spectrometry; Plants, Medicinal; Polycyclic Compounds; Reproducibility of Results; Schisandra

2013
In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:1

    Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tablets; Tacrolimus

2014
Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 63

    Topics: Animals; Base Sequence; Blotting, Western; Cells, Cultured; Cyclooctanes; Cytokines; Dinoprostone; Dioxoles; DNA Primers; Enzyme Activation; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; NADPH Oxidases; NF-kappa B; Nitric Oxide; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger

2014
Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:4

    Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cyclic AMP-Dependent Protein Kinases; Cyclooctanes; Dioxoles; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mice, Inbred ICR; Microglia; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Polycyclic Compounds; Reactive Oxygen Species; STAT Transcription Factors; Toll-Like Receptor 2

2014
Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-κB in mouse peritoneal macrophages.
    Immunopharmacology and immunotoxicology, 2014, Volume: 36, Issue:3

    Topics: Animals; Cyclooctanes; Cyclooxygenase 2; Dioxoles; I-kappa B Kinase; Lignans; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases

2014
[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:1

    Topics: Countercurrent Distribution; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
[Effect of forchlorfenuron on fruit morphology and lignans content of Schisandra chinensis].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:9

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Fruit; Lignans; Phenylurea Compounds; Polycyclic Compounds; Pyridines

2014
Hepatoprotective effect of Schisandra chinensis (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice.
    Food & function, 2014, Volume: 5, Issue:11

    Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Lignans; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred ICR; Plant Extracts; Polycyclic Compounds; Rubus; Schisandra

2014
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Acetaminophen; Activation, Metabolic; Animals; Apoptosis Regulatory Proteins; Benzoquinones; Binding Sites; Biomarkers; Catalytic Domain; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytoprotection; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione; Imines; Lignans; Liver; Liver Regeneration; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria, Liver; Molecular Docking Simulation; Protein Binding; Protein Conformation; Signal Transduction

2015
Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2015, Volume: 38, Issue:3

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Biological Availability; Blood Pressure; Cyclooctanes; Dioxoles; Disease Models, Animal; Hypertension; Lignans; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Plant Extracts; Polycyclic Compounds; Reactive Oxygen Species; Schisandra; Treatment Outcome; Vasodilator Agents

2015
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
    Chemico-biological interactions, 2015, Apr-25, Volume: 231

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dioxoles; Lignans; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Polycyclic Compounds; Protective Agents; Schisandra

2015
Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.
    Journal of ethnopharmacology, 2015, May-26, Volume: 166

    Topics: Administration, Oral; Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Kidney; Lignans; Liver; Liver Cirrhosis; Male; Polycyclic Compounds; Rats; Rats, Wistar; Tissue Distribution

2015
[Determination of lignanoids in seeds of Schisandra chinensis by combinative methods of fingerprint and QAMS].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:9

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds; Reproducibility of Results; Schisandra; Seeds

2014
Isolation of three dibenzocyclooctadiene lignans from in vitro cultures of Schisandra chinensis (Turcz.) Baill.--the first report.
    Die Pharmazie, 2015, Volume: 70, Issue:5

    Topics: Cells, Cultured; Chromatography, Thin Layer; Cyclooctanes; Dioxoles; Lignans; Magnetic Resonance Spectroscopy; Plant Leaves; Plant Shoots; Polycyclic Compounds; Schisandra

2015
Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:10

    Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glucuronosyltransferase; Herb-Drug Interactions; Lignans; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Structure-Activity Relationship

2015
Gomisin A is a Novel Isoform-Specific Probe for the Selective Sensing of Human Cytochrome P450 3A4 in Liver Microsomes and Living Cells.
    The AAPS journal, 2016, Volume: 18, Issue:1

    Topics: Anticarcinogenic Agents; Biosensing Techniques; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Enzyme Inhibitors; Hepatocytes; Humans; Hydroxylation; Kinetics; Lignans; Liver; Microsomes, Liver; Molecular Docking Simulation; Recombinant Proteins

2016
Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidant Response Elements; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Gene Expression Regulation; Hep G2 Cells; Humans; Lignans; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Protective Agents; RNA, Messenger; Schisandra; Signal Transduction

2016
Schisandrol B protects against cholestatic liver injury through pregnane X receptors.
    British journal of pharmacology, 2017, Volume: 174, Issue:8

    Topics: Animals; Cholestasis; Cyclooctanes; Dioxoles; Lignans; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Pregnane X Receptor; Receptors, Steroid; Signal Transduction

2017
Lignans from the fruits of Schisandra chinensis (Turcz.) Baill inhibit proprotein convertase subtilisin/kexin type 9 expression.
    Phytochemistry, 2017, Volume: 136

    Topics: Cyclooctanes; Dioxoles; Fruit; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Proprotein Convertase 9; Receptors, LDL; Schisandra; Serine Endopeptidases; Subtilisins

2017
Comparative Phytochemical Analysis of Chinese and Bay Starvine (Schisandra spp.): Potential for Development as a New Dietary Supplement Ingredient.
    Journal of dietary supplements, 2017, Nov-02, Volume: 14, Issue:6

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dietary Supplements; Dioxoles; Fruit; Lignans; Medicine, Chinese Traditional; Phenols; Phytochemicals; Plant Extracts; Polycyclic Compounds; Schisandra; Spectroscopy, Fourier Transform Infrared; Tannins

2017
Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooctanes; Cyclooxygenase 2; Cytokines; Dioxoles; Ethnopharmacology; Gene Expression Regulation; Lignans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Medicine, Korean Traditional; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Polycyclic Compounds; Prostatitis; Thioglycolates

2017
A sensitive UHPLC-MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study.
    Journal of separation science, 2017, Volume: 40, Issue:17

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Polycyclic Compounds; Reproducibility of Results; Tandem Mass Spectrometry

2017
Time- and NADPH-Dependent Inhibition on CYP3A by Gomisin A and the Pharmacokinetic Interactions between Gomisin A and Cyclophosphamide in Rats.
    Molecules (Basel, Switzerland), 2017, Aug-08, Volume: 22, Issue:8

    Topics: Animals; Cyclooctanes; Cyclophosphamide; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Drug Interactions; Enzyme Activation; Humans; Inhibitory Concentration 50; Lignans; Liver; Male; Microsomes, Liver; Molecular Structure; NADP; Rats

2017
Schisandrol B promotes liver regeneration after partial hepatectomy in mice.
    European journal of pharmacology, 2018, Jan-05, Volume: 818

    Topics: Animals; Cell Proliferation; Cyclooctanes; Dioxoles; Hepatectomy; Interleukin-6; Lignans; Liver; Liver Regeneration; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha

2018
Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells.
    Clinical and experimental pharmacology & physiology, 2018, Volume: 45, Issue:6

    Topics: Aging; Anti-Inflammatory Agents; Antioxidants; Autophagy; Cell Survival; Cyclooctanes; Dioxoles; Diploidy; Down-Regulation; Fibroblasts; Humans; Lignans; MAP Kinase Signaling System; NF-E2-Related Factor 2; NF-kappa B; Organelle Biogenesis; Oxidative Stress; Protein Transport; Reactive Oxygen Species

2018
[Determination of hepatic and small intestinal distribution of lignans of Wuzhi tablet in rats by liquid chromatography tandem mass spectrometry method].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:12

    Topics: Animals; Chromatography, Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Intestine, Small; Lignans; Liver; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Tablets; Tandem Mass Spectrometry

2016
[Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:10

    Topics: Acetic Acid; Animals; Bile; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Feces; Lignans; Liver Diseases, Alcoholic; Plasma; Polycyclic Compounds; Rats; Schisandra; Urine

2016
Simultaneous quantification of Schisandrin B enantiomers in rat plasma by chiral LC-MS/MS: Application in a stereoselective pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2018, Sep-10, Volume: 159

    Topics: Animals; Anti-Inflammatory Agents; Chromatography, Liquid; Cyclooctanes; Dioxoles; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tandem Mass Spectrometry

2018
Evaluation of the inhibition of human carboxylesterases (CESs) by the active ingredients from
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:11

    Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; Lignans; Microsomes, Liver; Molecular Docking Simulation; Polycyclic Compounds; Schisandra

2019
Effects of crushed Schisandra Fruit on the content of lignans in Kampo decoction.
    Journal of natural medicines, 2019, Volume: 73, Issue:2

    Topics: Adult; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Fruit; Humans; Lignans; Male; Medicine, Kampo; Polycyclic Compounds; Schisandra; Taste; Young Adult

2019
Effect of gomisin A on osteoblast differentiation in high glucose-mediated oxidative stress.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 66

    Topics: Animals; Antioxidants; Cell Differentiation; Cyclooctanes; Diabetes Mellitus; Dioxoles; Gene Expression Regulation; Glucose; Heme Oxygenase-1; Homeostasis; Humans; Lignans; Mice; Mitochondria; Organelle Biogenesis; Osteoblasts; Osteogenesis; Oxidative Stress; Protoporphyrins; Reactive Oxygen Species; Schisandra

2020
Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 68

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclooctanes; Dioxoles; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; Lung Neoplasms; MAP Kinase Kinase 4; Melanoma; Mice, Inbred C57BL; Xenograft Model Antitumor Assays

2020
Effects of 27 natural products on drug metabolism genes in channel catfish (
    Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Biotransformation; Cell Line; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Ictaluridae; Lignans; Polycyclic Compounds; Pregnane X Receptor

2020
Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2020, Volume: 37, Issue:9

    Topics: Benzopyrans; Butyrates; Chromatography, Liquid; Coumarins; Cyclooctanes; Dioxoles; Flavanones; Food Analysis; Fruit; Glucosides; Glycosides; Glycyrrhizic Acid; Herbal Medicine; Iridoids; Isoflavones; Lignans; Plant Roots; Plants, Medicinal; Polycyclic Compounds; Tandem Mass Spectrometry

2020
Effect of roasting temperature and time on volatile compounds, total polyphenols, total flavonoids, and lignan of omija (Schisandra chinensis Baillon) fruit extract.
    Food chemistry, 2021, Feb-15, Volume: 338

    Topics: Cooking; Cyclooctanes; Dioxoles; Flavonoids; Fruit; Lignans; Plant Extracts; Polycyclic Compounds; Polyphenols; Schisandra; Temperature; Volatile Organic Compounds

2021
Inhibitory Effectiveness of Gomisin A, a Dibenzocyclooctadiene Lignan Isolated from
    International journal of molecular sciences, 2020, Nov-21, Volume: 21, Issue:22

    Topics: Animals; Cell Line; Cyclooctanes; Dioxoles; Ion Transport; Kinetics; Lignans; Potassium Channels, Voltage-Gated; Rats; Schisandra; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels

2020
Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 84

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Hepatomegaly; Humans; Lignans; Liver; Male; Mice, Inbred C57BL; Organ Size; Pregnane X Receptor; Schisandra; Signal Transduction; Transcription Factors; YAP-Signaling Proteins

2021
Gomisin A Alleviates Obesity by Regulating the Phenotypic Switch between White and Brown Adipocytes.
    The American journal of Chinese medicine, 2021, Volume: 49, Issue:8

    Topics: 3T3-L1 Cells; Adipocytes, Brown; Adipose Tissue, Brown; Animals; Cyclooctanes; Diet, High-Fat; Dioxoles; Lignans; Mice; Mice, Inbred C57BL; Obesity

2021
Examination of the Impact of CYP3A4/5 on Drug-Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.
    International journal of molecular sciences, 2022, Apr-19, Volume: 23, Issue:9

    Topics: Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dioxoles; Drug Interactions; Humans; Immunosuppressive Agents; Lignans; Models, Biological; Polycyclic Compounds; Tacrolimus

2022
Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor.
    Biochemical pharmacology, 2022, Volume: 204

    Topics: Caspase 3; Cholestasis; Cyclooctanes; Dioxoles; Humans; Inflammasomes; Lignans; Lithocholic Acid; Liver; Luciferases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidoreductases; Pregnane X Receptor; Pyroptosis

2022
A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106

    Topics: Animals; Biomarkers; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds; Rats; Schisandra

2022
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
    Oncology reports, 2022, Volume: 48, Issue:5

    Topics: Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Complex Mixtures; Cyclin B1; Cyclin-Dependent Kinase 4; Cyclooctanes; Cysteine; Dioxoles; Eosine Yellowish-(YS); Female; Humans; Lignans; Mice; Ovarian Neoplasms; Oxidative Stress; Paclitaxel; Reactive Oxygen Species

2022