schizandrin b has been researched along with lignans in 299 studies
| Studies (schizandrin b) | Trials (schizandrin b) | Recent Studies (post-2010) (schizandrin b) | Studies (lignans) | Trials (lignans) | Recent Studies (post-2010) (lignans) |
|---|---|---|---|---|---|
| 321 | 1 | 218 | 7,024 | 95 | 4,172 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (3.01) | 18.7374 |
| 1990's | 19 (6.35) | 18.2507 |
| 2000's | 54 (18.06) | 29.6817 |
| 2010's | 169 (56.52) | 24.3611 |
| 2020's | 48 (16.05) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, GT; Wang, BE; Zhang, TM | 2 |
| Liu, GT; Pan, Y; Wei, HL; Xue, JY | 1 |
| Hou, JW; Li, XJ; Xin, WJ; Yan, LJ; Zhao, BL | 1 |
| Liu, GT; Lu, H | 2 |
| Jia, WY; Li, XJ; Liu, GT; Xin, WJ; Zhao, BL | 1 |
| Song, WZ; Tong, YY; Wang, K | 1 |
| Liu, GT | 2 |
| Li, Y; Liu, GT | 1 |
| Bao, TT; Liu, GT; Song, ZY; Wei, HL | 1 |
| Liu, LS; Wang, XX; Xiao, XH; Zheng, RL; Zhou, XF | 1 |
| Cresteil, T; Le Provost, E; Lesca, P; Liu, KT | 1 |
| Lesca, P; Liu, KT | 2 |
| Che, CT; Ip, SP; Ko, KM; Kong, YC; Ng, KH; Poon, MK; Wu, SS | 1 |
| Cai, Y; He, Y; Zhu, Z | 1 |
| Che, CT; Ip, SP; Ko, KM; Kong, YC; Ng, KH; Poon, MK | 1 |
| Ip, SP; Ko, KM; Li, PC; Mak, DH; Poon, MK | 1 |
| Ip, SP; Ko, KM | 1 |
| Che, CT; Ip, SP; Ko, KM; Ma, CY | 1 |
| Ko, KM; Mak, DH | 1 |
| Ko, KM; Yim, TK | 2 |
| Ahn, KS; Jung, KY; Lee, HK; Lee, IS; Oh, SR; Park, SH | 1 |
| Che, CT; Ip, SP; Ko, KM | 1 |
| Ip, SP; Ko, KM; Yiu, HY | 2 |
| Han, Y; Sun, H; Wang, D; Wang, X; Yuan, C | 1 |
| Ko, KM; Yiu, HY | 1 |
| Che, CT; Ip, SP; Ko, KM; Kong, YC | 1 |
| Carlier, PR; Han, YF; Ko, KM; Lam, BY; Mak, DH; Pan, SY; Pang, YP | 1 |
| Ko, KM; Lam, BY | 1 |
| Chiu, PY; Ko, KM; Mak, DH; Poon, MK | 2 |
| Yang, SB | 1 |
| Chiu, PY; Ko, KM; Mak, DH; Poon, MK; Tang, MH | 1 |
| Chiu, PY; Ko, KM; Tang, MH | 1 |
| Chiu, PY; Ko, KM | 4 |
| Kim, SH; Kim, SR; Kim, YC; Koo, KA; Lee, MK; Lee, NG; Markelonis, GJ; Oh, TH; Sung, SH; Yang, JH | 1 |
| Burgos, RA; Folch, H; Hancke, JL; Hermosilla, R; Hidalgo, MA; Matthei, SM | 1 |
| Liu, GT; Sun, YM; Yu, LH; Zhang, HY | 1 |
| Cao, MF; Chen, F; Gao, YP; Qian, KX; Wang, T; Wu, YF; Zumbika, EP | 1 |
| Li, JQ; Li, P; Mu, J; Zhang, LQ; Zhu, XL | 1 |
| Huang, T; Shen, P; Shen, Y | 1 |
| Anjia, C; Cunhong, L; Wenhua, G; Xingguo, C; Zhide, H | 1 |
| Hu, X; Lu, Q; Qiangrong, P; Wang, T | 1 |
| Chen, F; Chen, W; Li, L; Wang, T; Xu, ZL; Yu, Y | 1 |
| Hu, X; Lu, Q; Pan, Q; Zhang, K | 1 |
| Hu, X; Li, L; Lu, Q; Shen, Y | 1 |
| Hu, X; Lu, Q; Pan, Q; Sun, M; Xu, X | 1 |
| Dong, H; Han, YF; Ko, KM; Li, WY; Pan, SY; Zhao, XY | 1 |
| Chiu, PY; Ko, KM; Leung, HY; Poon, MK | 1 |
| Chiu, PY; Ko, KM; Leung, HY; Mak, DH; Poon, MK | 2 |
| Chiu, PY; Ko, KM; Lee, SS; Leung, HY; Poon, MK | 1 |
| Liu, W; Luo, HM; Wu, JH; Yu, R | 1 |
| Chiu, PY; Ko, KM; Leung, HY; Poon, MK; Siu, AH | 2 |
| Han, W; Hu, X; Li, L; Liu, Z; Pan, Q | 1 |
| Jin, XD; Li, L; Li, YZ; Liu, XN; Zhang, CY; Zheng, XZ | 1 |
| Huang, M; Jin, J; Liu, GT; Sun, H | 1 |
| Avula, B; Choi, YW; Khan, IA; Khan, SI; Madgula, VL; Pullela, SV; Walker, LA | 1 |
| Dong, H; Fang, HY; Fong, WF; Ko, KM; Pan, SY; Xiang, CJ; Yu, ZL; Zhao, XY | 1 |
| Chiu, PY; Ko, KM; Leung, HY | 1 |
| Chiu, PY; Ko, KM; Leung, HY; Luk, KF; Ng, KM | 2 |
| Chen, N; Chiu, PY; Ko, KM | 1 |
| Caichompoo, W; Gao, HJ; Hou, TT; Qin, LP; Zhang, QY; Zhou, XJ | 1 |
| Huang, X; Liu, SY; Liu, ZQ; Song, FR | 1 |
| Chang, CY; Chen, JR; Chen, YL; Huang, CC; Huang, GC; Li, JS; Tsi, D; Yang, SC | 1 |
| Hamamori, Y; Ko, KM; Konishi, T; Magara, T; Nakajima, Y; Nishida, H; Tatewaki, N | 1 |
| Wang, B; Wang, XM | 1 |
| Lavazza, A; Li Volti, G; Rezzani, R; Rodella, LF; Stacchiotti, A | 1 |
| Chen, J; Xiang, Q; Yang, X | 1 |
| Liu, C; Wu, H; Zhang, S | 1 |
| Ji, H; Liu, H; Liu, Y; Shao, B; Tang, J; Wu, L; Zhu, D | 2 |
| Chen, N; Chiu, PY; Ko, KM; Leong, EP; Leung, HY; Poon, MK | 1 |
| Choi, IW; Choi, YH; Choi, YW; Hwang, WD; Jeong, YK; Jin, CY; Kim, GY; Kim, JH; Kim, SG; Kim, SK; Lee, YJ; Park, C; Park, DJ | 1 |
| Bae, DS; Kim, CY; Kim, YH; Lee, HJ; Lee, JK; Oh, SY; Pan, CH; Um, BH | 1 |
| Chen, W; Gao, S; Sun, L; Tai, Z; Wei, H; Xu, W | 1 |
| Gao, Q; Li, X; Luo, H; Weng, W; Xiao, F | 1 |
| Hu, Y; Sun, R; Yu, J; Zhou, J | 1 |
| Che, FF; Liu, Y; Xu, CG | 1 |
| Li, WL; Su, MW; Xin, HW; Xiong, L | 1 |
| Chen, N; Ko, M | 1 |
| Lin, X; Shaw, PC; Song, JX; Sze, SC; Tong, Y; Wong, RN; Zhang, YB | 1 |
| Chen, N; Chiu, PY; Ko, KM; Lam, PY; Leong, PK; Leung, HY | 1 |
| Groundwater, P; He, CY; Li, PY; Liu, JP; Lu, D; Yan, ZW | 1 |
| Fan, LH; Guo, M; Li, SF; Liu, TF; Wang, ZP | 1 |
| Cai, BC; Chen, XM; Di, LQ; Han, L; Li, JS; Li, W; Liu, XH | 1 |
| Chiu, PY; Ko, KM; Lam, PY; Leung, HY; Yan, CW | 1 |
| Che, CT; Chen, Y; Ip, SP; Ko, KM; Lai, PB; Mao, QQ; Ng, EW; Poon, TC; Xian, YF | 1 |
| Inujima, A; Koizumi, K; Saiki, I; Sakurai, H; Shin, MS; Waiwut, P; Zhou, Y | 1 |
| Chen, N; Chiu, PY; Ko, KM; Leong, PK; Leung, HY | 1 |
| Chen, N; Chiu, PY; Ko, KM; Leong, PK; Leung, H | 1 |
| Chen, Q; Cheng, NN; Li, YL; Wang, YM; Wu, YJ | 1 |
| Chiu, PY; Ko, KM; Lam, PY; Yan, CW | 1 |
| Deng, Y; Liu, W; Wei, Y; Xu, B; Xu, Z; Yang, H | 1 |
| Chae, HS; Choi, JG; Han, SH; Kang, OH; Keum, JH; Kim, SB; Kim, YS; Kwon, DY; Mun, SH; Oh, YC; Shin, DW | 1 |
| Dong, H; Fong, WF; Guo, BF; Han, YF; Ko, KM; Pan, SY; Yu, ZL; Zhang, Y | 1 |
| Guan, M; Li, T; Liu, Y; Sheng, Y; Wang, Y; Yuan, G | 1 |
| Giridharan, VV; Ko, KM; Konishi, T; Sato, S; Thandavarayan, RA | 1 |
| Aleo, MF; Lavazza, A; Li Volti, G; Rezzani, R; Rodella, LF; Schena, I; Stacchiotti, A | 1 |
| Chan, PK; Chu, JH; Fong, WF; Pan, SY; Wang, H; Ye, Y; Yu, ZL | 1 |
| Chen, N; Ko, KM; Leong, PK | 1 |
| Fan, LH; Guo, M; Liu, ML; Liu, TF; Si, SJ; Wang, ZP | 1 |
| Che, F; Liu, Y; Xu, C | 1 |
| Bhilwade, HN; Giridharan, VV; Ko, KM; Konishi, T; Thandavarayan, RA; Watanabe, K | 1 |
| Chiu, PY; Ko, KM; Leong, PK; Leung, HY | 1 |
| Chun, JN; Jeon, JH; Kim, CY; Kim, HK; Kim, SH; Lee, HJ; Lee, SW; Park, EJ; Park, JK; So, I | 1 |
| Hu, X; Liu, Z; Pan, Q; Sun, F; Sun, J; Xu, Y; Yan, Z | 1 |
| Inoue, H; Saiki, I; Sakurai, H; Shimada, Y; Waiwut, P | 1 |
| Ma, CH; Yang, FJ; Yang, L; Zhang, Y; Zhao, CJ; Zu, YG | 1 |
| Chiu, PY; Ko, KM; Leong, PK | 1 |
| Cai, J; Chi, D; Huang, Q | 1 |
| Ko, KM; Lam, PY | 1 |
| Fu, H; Liu, GX; Wang, XM; Zeng, KW; Zhang, T | 1 |
| Chen, M; Huang, M; Huang, Z; Jin, J; Qiu, Y; Wang, Y; Zhu, S | 1 |
| Bhilwade, HN; Checker, R; Konishi, T; Menon, J; Patwardhan, RS; Sandur, SK; Sharma, D; Thoh, M | 1 |
| Jung, CH; Lee, DH; Lee, TH | 1 |
| Dong, JP; He, FC; Li, SX; Liu, WZ; Su, RQ; Zhao, ZQ | 1 |
| Kang, K; Kim, CY; Lee, HJ; Lee, KM; Nho, CW; Yoo, JH | 1 |
| Ikeya, Y; Nishizawa, M; Okumura, T; Qian, HY; Takimoto, Y; Yoshigai, E | 1 |
| Han, Y; Sun, H; Wang, X; Wei, W; Wu, F; Zhang, A | 1 |
| Cao, HH; Chan, CL; Cheng, CY; Fong, WF; Hu, YM; Kwan, HY; Pan, SY; Tse, KW; Wu, YC; Yu, ZL | 1 |
| Guan, CW; Huang, ZY; Jin, J; Li, J; Li, M; Qiu, YW; Wang, WW | 1 |
| Bi, K; Chen, X; Fan, R; Geng, L; He, B; Jia, Y; Li, Q; Su, D; Wei, B; Zhao, L | 1 |
| Chen, H; Huang, ZJ; Lu, TL; Mao, CQ; Song, Y; Sun, Y; Wu, XY; Xu, B; Zhou, Y | 1 |
| Cui, B; Guan, J; Zhang, X; Zhao, L; Zhao, X; Zhu, H | 1 |
| Li, WL; Wu, XC; Xin, HW; Yu, AR | 1 |
| Ekiert, H; Szopa, A | 1 |
| Hu, X; Liu, Z; Zhang, B | 1 |
| Ando, H; Kondo, S; Konishi, T; Nishida, H; Sakamaki, T; Tatewaki, N; Yoshida, M | 1 |
| Chen, H; Hu, JP; Li, Y; Sheng, L; Wang, BL | 1 |
| Guo, YX; Wang, LH; Zhang, DY; Zhang, YB; Zhou, LL | 1 |
| Jia, ZH; Ko, KM; Pan, SY; Sun, N; Wang, XY; Yu, Q; Yu, ZL; Zhang, Y; Zhu, PL | 1 |
| Antoine, MH; Bunel, V; Duez, P; Nortier, J; Stévigny, C | 1 |
| Bi, HC; Chen, X; Huang, M; Li, JL; Qin, XL; Wang, CX; Wang, XD; Wang, Y; Xue, XP; Yang, H; Zhong, GP | 1 |
| Bae, YS; Choi, YW; Ko, MJ; Lee, SJ; Park, SY | 1 |
| Chen, Y; Li, L; Xin, Y; Xing, G; Zhang, T; Zhou, L | 1 |
| Chen, B; Chen, P; Gao, W; Liu, J; Meng, H; Pang, S; Tao, Z; Wang, L; Xu, Z; Yang, N; Yang, Z; Zhang, M; Zhou, N | 1 |
| Deng, X; Meng, Q; Shen, C | 1 |
| Dai, G; Ji, D; Li, L; Lu, T; Mao, C; Sun, Y; Wu, X; Xu, B; Yin, F; Zhou, Y | 1 |
| Bae, DJ; Chun, JN; Jeon, JH; Kim, HK; Kim, IS; Kim, SY; Kwon, EJ; Lee, SW; Park, EJ; Park, HH; Park, JK; So, I | 1 |
| Bi, K; Jia, Y; Li, H; Liu, B; Liu, Z; Mao, X; Zhang, C; Zhao, X | 1 |
| Han, L; Qu, J; Qu, Q; Wu, LX; Zhan, M; Zhang, W; Zhang, YW; Zhou, HH | 1 |
| Guo, C; Hao, H; Kang, A; Wang, G; Wang, H; Xie, Y | 1 |
| Chu, ZY; Tian, L; Wu, LH | 1 |
| Cai, H; Che, GY; Cong, YL; Jin, B; Li, ZY; Liu, Y; Si, L; Sun, YX; Tang, B; Wang, AB; Wang, CF; Zhang, XM | 1 |
| Chen, L; Chen, T; Ding, P; Li, XK; Song, X; Wang, B | 1 |
| Carrara, M; Casarin, E; Dall'Acqua, S; Innocenti, G; Slapetová, T; Smejkal, K | 1 |
| Bao, RF; Cao, Y; Hu, YP; Jiang, L; Li, HF; Li, ML; Liu, F; Liu, YB; Lu, W; Mu, JS; Shu, YJ; Tan, ZJ; Wang, XA; Weng, H; Wu, WG; Wu, XS; Xiang, SS; Ye, YY; Zhang, F | 1 |
| He, LH; Hu, KY; Jia, ZR; Li, SR; Li, XJ; Mao, J; Tian, W; Wang, DW; Yang, Y; Zhang, W | 1 |
| Cheng, Q; Ji, B; Liu, J; Wang, O; Wang, Y; Zhao, L; Zhou, F | 1 |
| Chu, ZS; Ko, KM; Pan, SY; Sun, N; Wang, XY; Yu, ZL; Zhang, Y; Zhou, SF; Zhu, PL | 1 |
| Adámková, L; Carnecká, M; Humpa, O; Páchniková, G; Porubová Koubíková, L; Slanina, J; Slaninová, I; Smejkal, K | 1 |
| Deng, Y; Feng, S; Liu, W; Xu, B; Xu, Z; Yang, T | 1 |
| Corona, A; Del Vecchio, C; Esposito, F; Grandi, N; Mandas, D; Parolin, C; Piano, D; Tramontano, E; Xu, L | 1 |
| Arumugam, S; Giridharan, VV; Ko, KM; Konishi, T; Krishnamurthy, P; Suzuki, K; Thandavarayan, RA; Watanabe, K | 1 |
| Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H | 1 |
| Chen, JG; Fan, XT; Jiang, EP; Jing, S; Li, H; Sun, HX; Wang, CM; Wang, S; Yu, CR; Yu, CY | 1 |
| Chan, CL; Chao, X; Dai, W; Fong, WF; Fu, X; Kwan, HY; Lee, KC; Li, T; Lu, A; Niu, X; Pan, SY; Su, T; Tong, T; Tse, AK; Yi, H; Yu, H; Yu, ZL | 1 |
| Liu, CH; Liu, S; Tao, YY; Yang, T; Zheng, TH | 1 |
| Cai, Q; Du, SS; Zheng, LS | 1 |
| He, ZX; Hu, C; Jin, H; Ko, KM; Pan, SY; Yang, T; Yu, ZL; Zhang, X; Zhang, Y; Zhou, SF; Zhou, ZW | 1 |
| Elofsson, M; Hakala, E; Hanski, L; Uvell, H; Vuorela, H; Vuorela, PM; Yrjönen, T | 1 |
| Chen, Y; Dong, Q; Hou, H; Wu, J | 1 |
| Deng, S; Guo, CX; Liu, ZQ; Yin, JY; Zhang, W; Zhou, HH | 1 |
| Gao, W; Hou, W; Liu, Q; Wang, D; Wang, Y; Zheng, S | 1 |
| Lin, HC; Wang, GL; Zhang, LX; Zhu, HY | 1 |
| Ba, Q; Cui, C; Feng, S; Wen, L; Yang, K; Zhou, J | 1 |
| Bao, J; Du, C; Jiang, Y; Liu, C; Tong, Q; Wang, J; Zhang, Q | 2 |
| Chen, H; Liu, W; Liu, Y; Lu, Q; Wang, Z; Yu, T | 1 |
| Arumugam, S; Giridharan, VV; Ko, KM; Konishi, T; Krishnamurthy, P; Mizuno, M; Nawa, H; Suzuki, K; Thandavarayan, RA; Watanabe, K | 1 |
| Du, X; Gao, Z; Li, L; Li, Q; Shen, L; Zhang, J; Zhao, Z; Zou, Y | 1 |
| Bian, H; Cai, J; Cai, Z; Liu, J; Zhu, G | 1 |
| Jang, MK; Jung, MH; Kim, JH; Kim, SH; Yun, YR | 1 |
| Chen, XL; Chen, ZC; Cheng, DJ; Guo, YL; Ma, LJ; Tang, XY; Tian, CJ; Zhang, LX; Zhang, XY; Zhao, LM | 1 |
| Bonilla, S; Cho, J; Chong, L; Jin, ZB; Ko, KM; Leung, YF; Liu, Y; Ma, P; Pang, CP; Venkatraman, P; Xiang, L; Zhang, L; Zhang, M | 1 |
| Chen, Z; Dong, C; Gao, J; Guo, M; Jing, Z; Liu, T; Song, G; Zhang, Y | 1 |
| Chan, WM; Chen, J; Ko, KM; Leong, PK; Leung, HY; Wong, HS | 1 |
| Mu, Y; Wang, S; Yang, X; Zheng, Y | 1 |
| Cao, B; Chen, H; Gao, C; Hu, J; Niu, C | 1 |
| Araki, R; Hiraki, Y; Inatomi, Y; Nishida, S; Yabe, T | 1 |
| Ko, KM; Leong, PK | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Ozaki, K; Shindo, S | 1 |
| Jung, MH; Kim, JH; Yun, YR | 1 |
| Jang, MK; Jung, MH; Kim, JH; Park, MH; Yun, YR | 1 |
| Chu, ZS; Ko, KM; Pan, SY; Wang, XY; Xie, M; Yu, ZL; Zhang, Y; Zhao, J; Zhou, SF; Zhu, PL | 1 |
| Bu, R; Chen, Y; Fan, Y; Gao, Y; Jia, J; Li, G; Liu, L; Wu, J; Yan, D; Yang, F; Zhang, S | 1 |
| Chae, JK; Jeong, M; Kim, CY; Kim, H; Kim, SY; Park, YU; Subedi, L | 1 |
| An, BS; Choi, YW; Hong, EJ; Hong, SH; Jeung, EB; Lee, GS; Li, M | 1 |
| Liu, N; Yang, L; Zhao, JH; Zheng, JX; Zhou, ZK; Zhuang, YS | 1 |
| Bradbury, EJ; Brown, CF; Lyles, JT; Nelson, K; Pierce, ST; Quave, CL; Tyler, P | 1 |
| Cao, B; Chen, H; Li, GF; Liu, B; Wang, PL; Wei, F; Wei, LQ; Yu, X; Zhang, D | 1 |
| Han, D; Hu, ZM; Huo, HJ; Qiu, QH; Xin, DQ; Xing, WH; Yang, XJ; Zhao, Y | 1 |
| Guo, S; Lin, Q; Meng, Y; Qin, X; Qin, Z; Shi, M | 1 |
| Geng, Y; Guo, F; Li, S; Wang, S; Wei, J; Wu, H; Yang, H; Yu, Y; Zhang, M | 1 |
| Cheon, SM; Cho, HY; Ham, SH; Kim, SJ; Ko, SM; Kwon, YD; Lee, YB; Shin, H | 1 |
| Jung, TH; Kim, JM; Lee, J; Lee, YM; Park, SM; Ryu, HS | 1 |
| Meng, F; Sun, Z; Zhang, W | 1 |
| Cao, Y; Chen, Q; Li, Y; Sun, S; Zhang, G; Zhang, H; Zhang, J | 1 |
| Li, P; Lin, L; Shao, M; Wang, A; Wang, S; Wang, Y | 1 |
| Cheng, Y; Hu, K; Wang, G; Wang, Z; Yang, J; Yang, Y; You, L | 1 |
| Lai, Q; Lai, S; Li, T; Luo, Z; Wang, Q; Wei, H; Wu, C; Yu, Y | 1 |
| Chan, CL; Chao, XJ; Fong, WF; Fu, X; Kwan, HY; Liu, B; Su, T; Tse, AKW; Wu, J; Yu, H; Yu, ZL | 1 |
| An, F; Guo, M; Hong, M; Lu, Y; Wei, X | 1 |
| Chen, ZC; Cheng, DJ; Guo, YL; Li, XS; Ma, LJ; Tang, XY; Tian, CJ; Zhang, LX; Zhang, XY; Zhao, LM | 1 |
| An, F; Guo, M; Hong, M; Lu, Y; Wei, X; Yu, H | 1 |
| Han, G; Shao, M; Yang, W | 1 |
| Jia, R; Liu, F; Liu, Y; Miao, M; Wang, H; Wang, Q; Yang, Z; Zhang, H; Zhao, H | 1 |
| Jung, DY; Jung, MH; Kim, JH; Lee, H | 1 |
| Cai, C; Xiang, Y; Zeng, C; Zhao, X; Zhou, A; Zhu, N | 1 |
| Dai, S; Dong, L; Li, H; Liu, Q; Song, J | 1 |
| Chen, L; Hu, Q; Huang, S; Lu, Y; Xia, C; Xiong, Y; Zhang, H | 1 |
| Chang, J; Li, R; Li, Z; Liu, XC | 1 |
| Chen, J; Gao, J; Li, H; Li, N; Liu, J; Sun, J; Wang, C; Wang, M; Yu, Z; Zhu, K | 1 |
| Li, M; Li, ZC; Tang, M; Wu, Y; Yao, LQ | 1 |
| Bao, J; Chen, W; He, Y; Hu, P; Jiang, L; Ma, C; Moqbel, SAA; Ran, J; Wu, L; Xiong, Y; Xu, K; Xu, L | 1 |
| Feng, YL; Li, W; Liu, KY; Liu, YL; Song, YG; Su, D; Yang, LJ | 1 |
| Cheng, X; Ding, XY; Ji, JD; Lu, TL; Mao, CQ; Su, LL; Wang, LJ; Zhang, J | 1 |
| Feng, JH; Guo, C; Hou, JQ; Hu, XL; Wang, H; Xiong, F; Ye, WC; Zhang, XQ | 1 |
| Bai, HY; Feng, S | 1 |
| Fang, L; Guo, X; Han, X; Leng, A; Li, D; Peng, J; Qi, Y; Sun, C; Wang, R; Yin, L | 1 |
| Dai, X; Guo, G; Liang, G; Qian, J; Wang, O; Yin, C; Zhang, X; Zhang, Y; Zhao, C | 1 |
| Jung, DY; Jung, MH; Kim, JH; Lee, H; Nagappan, A | 1 |
| Chen, Y; Deng, W; Ding, M; Gao, S; Gao, Y; He, G; Hu, Z; Li, T; Shu, P; Wang, F | 1 |
| Adlat, S; Han, T; Jiang, N; Nasser, MI; Tian, Y | 1 |
| Bai, X; Gu, Z; Jin, H; Miao, J; Shao, Z; Wang, Q; Wang, X; Wang, Z; Wu, J | 1 |
| Feng, Z; Li, X; Liang, G; Mou, Z; Qian, J; Xu, Z; Zheng, X; Zhuang, F | 1 |
| Du, Z; Fu, Q; Hu, CM; Hu, RX; Yang, K; Zhang, X | 1 |
| Ji, ZR; Xue, WL; Zhang, L | 1 |
| Ding, WF; Lin, JR; Qin, JH; Wu, WH | 1 |
| Han, J; Jiang, L; Shi, F; Shi, X; Xu, J; Zhang, B; Zheng, Z | 1 |
| Feng, S; Liu, K; Qiu, B; Xu, X; Zhu, H; Zou, L | 1 |
| Freysdottir, J; Hanski, L; Karhu, E; Kortesoja, M; Olafsdottir, ES | 1 |
| Li, PB; Liang, FY; Ouyang, XS; Pei, Z; Su, WW; Wang, JW | 1 |
| Chen, AC; Chen, WC; Lu, CK; Ueng, YF; Wang, HJ | 1 |
| Guo, SE; Huang, Q; Lin, QN; Liu, YD; Qin, X; Zhang, ZM; Zhou, R | 1 |
| Cao, Q; Chen, C; Chen, X; Chen, Z; Ding, D; Gao, X; He, L; Hu, K; Li, J; Lu, Y; Luo, Y; Qi, R; Quan, F; Sun, R; Tao, W; Wang, D; Yang, Y; Yang, Z; Zhao, D; Zhao, S | 1 |
| Bi, K; Gao, H; Li, Q; Liu, H; Liu, R; Lv, X; Xu, H; Zhang, M; Zhang, Q; Zhang, Y | 1 |
| Chen, T; Huang, W; Liang, G; Qian, J; Qian, Y; Wang, J; Wang, Z; Wu, G; You, S | 1 |
| Chen, Q; Dahan, A; Tan, W; Wei, L; Xue, J; Zhang, G; Zhang, H | 1 |
| Ding, CY; Dong, ST; Dong, ZJ; Li, YJ; Liu, HT; Meng, L; Wang, LS; Xing, XQ; Xue, CJ | 1 |
| Cheng, L; Fei, L; Han, X; Nie, S; Pan, H; Ren, Y; Sun, Z; Wang, M; Xie, J; Yang, Z; Zhang, W; Zhao, Y | 1 |
| Cao, G; Chen, J; Diao, LT; Du, B; Li, H; Li, S; Shi, H; Yin, P; Zhong, Y | 1 |
| Chao, X; Cuiqiong, W; Xinling, F; Yinyan, J | 1 |
| Cai, NN; Jiang, Y; Wang, ZZ; Yang, R; Zhang, XM; Zhu, WQ; Zhu, XC | 1 |
| Bi, XJ; Cai, F; Fu, M; He, SY; Jia, LQ; Jing, M; Kong, L; Li, XT; Liu, JJ; Liu, XZ; Yao, XM; Zhang, L | 1 |
| Cai, FY; Fu, M; He, SY; Jing, M; Ju, RJ; Kong, L; Li, XT; Liu, JJ; Liu, XZ; Yao, XM; Zhang, L | 1 |
| Chei, S; Jin, H; Kim, KJ; Lee, BY; Lee, K; Lee, YJ; Oh, HJ | 1 |
| Chen, C; Huang, H; Nasser, MI; Zhao, M; Zhu, P; Zhu, S | 1 |
| Ahn, SJ; In, S; Kim, E; Kim, HJ; Lee, A; Min, SS | 1 |
| Jiang, SJ; Lam, HYP; Liang, TR; Peng, SY | 1 |
| Cheng, Y; Elkin, K; Fan, X; Gu, J; Ji, X; Liang, J; Shi, Y; Wang, C; Zhang, Z | 1 |
| Bai, JX; Chen, YJ; Chou, JY; Fu, XQ; Lam, DF; Li, JK; Liang, C; Liu, YX; Wang, YP; Wu, JY; Wu, Y; Yin, CL; Yu, ZL; Zhu, PL | 1 |
| Liao, X; Pang, Y; Wang, X; Wei, L; Zhang, Y | 1 |
| Cheon, CK; Lee, JH; Lee, JY | 1 |
| Zhang, PX; Zhao, LK; Zhao, YB | 1 |
| Jing, M; Li, QQ; Li, QS; Li, XY; Shi, LX; Wang, YL; Yao, XM | 1 |
| Fei, Y; Hai-Zhen, C; Jiang-Pei, S; Jun-Yi, S; Nian-Ping, F; Xiao-Yan, GU; Xing-Mei, X; Ying, L; Zi-Fei, J | 1 |
| Huang, L; Huang, Y; Li, L; Ma, L; Rong, W; Shen, Y; Tao, Y; Wang, R; Xu, X; Yang, C; Yang, T; Yao, X; Zhang, R; Zhang, Y; Zhou, H | 1 |
| Guo, J; Hu, S; Lin, X; Liu, J; Ma, Z; Shen, Y; Wang, J; Xu, G; Zhao, W; Zhou, J | 1 |
| Chia-Hui Tan, E; Chiang, TY; Lee, IJ; Ueng, YF; Wang, HJ; Wang, YC; Yun, CH | 1 |
| Chen, J; Li, H; Li, Z; Su, X; Wang, Y; Zhao, N; Zhuang, W | 1 |
| Bao, CJ; Du, YF; Duan, JL; Lin, RC; Liu, R; Liu, YX; Lu, WL; Luo, Q; Ma, S; Meng, XD; Xie, Y; Xu, JR; Yang, WP; Zhang, Z; Zhao, CJ; Zou, DX | 1 |
| Hwang, ET; Jeong, J; Joo, YE; Kim, KR | 1 |
| Chen, X; Jiang, Y; Jiang, Z; Li, W; Wang, M; Xiao, Z | 1 |
| Lam, HYP; Liang, TR; Peng, SY | 2 |
| Chen, H; Chen, J; Chen, Y; Kong, Y; Li, L; Wang, Q; Xie, H | 1 |
| Hu, Y; Li, H; Li, R; Tian, Y; Wu, Z | 1 |
| He, SY; Ju, RJ; Kong, L; Li, XT; Liu, XZ; Liu, Y; Zang, J; Zhang, L | 1 |
| Chen, H; Guo, J; Lin, X; Liu, J; Shen, Y | 1 |
| Pu, Z; Shen, C; Wang, W; Wang, X; Yin, Q; Zhang, W | 1 |
| Pu, Z; Wang, M; Xie, H; Xu, M; Zhang, W; Zhao, J | 1 |
| Chen, J; Hua, M; Li, Z; Sun, Y; Xia, Y; Zhao, L | 1 |
| Cheng, PC; Lam, HYP; Peng, SY | 1 |
| Guo, M; Ma, R; Wang, X; Wu, L; Zhan, Y; Zhang, Y | 1 |
| Chen, S; Ding, YH; Shi, SS; Tu, XK | 1 |
| Chen, J; Huang, Y; Luo, J; Luo, X; Tan, T; Wang, N; Wang, Y; Wei, M; Yang, S; Ye, C; Zhang, J | 1 |
| Chang, JH; Chiang, CY; Chuang, HC; Fan, CK; Hou, TY; Lee, YL; Lin, CL | 1 |
| Chen, H; Chen, M; Dong, B; Feng, Q; He, L; Jiang, L; Jin, R; Qi, Q; Wang, Y; Wu, N | 1 |
| Cheng, BC; Luo, G; Pan, SY; Qiu, XY; Song, XL; Wang, QG; Wang, YW; Yan, LS; Zhang, C; Zhang, SF; Zhang, Y; Zhou, XH | 1 |
| Ji, Y; Liu, T; Tan, S; Yao, X; Yu, M; Zheng, Z | 1 |
| Cao, Y; Cheng, L; Gao, Z; Wang, L; Wang, T; Wu, W; Zhang, Q | 1 |
| Ahn, J; Ha, TY; Hahm, JH; Jung, CH; Kim, MJ; Seo, HD; Yoo, A | 1 |
| Bi, K; Li, Q; Li, S; Xu, H; Yang, P; Zhang, Q; Zhang, Y | 1 |
| Pu, P; Shi, H; Tang, H; Yan, Y; Yang, H | 1 |
| Han, J; Huang, L; Huh, JY; Ji, L; Liang, G; Luo, W; Pavlov, VN; Samorodov, AV; Wang, Y; Yang, D; Yin, L; Zhang, Q; Zhu, W; Zhuang, Z | 1 |
| Gao, Y; Jin, MX; Li, HF; Li, S; Li, Y; Liang, KY; Pan, MX; Peng, Q; Wang, P; Wang, Y; Ye, L; Zhang, Y; Zhou, M; Zhou, SQ; Zhou, YQ; Zhu, XJ | 1 |
| Ding, T; Jin, H; Ma, M; Song, A; Wei, N; Yang, J; Zheng, S | 1 |
5 review(s) available for schizandrin b and lignans
| Article | Year |
|---|---|
[Biochemical and pharmacologic effects of wuweizi (Schizandra chinensis (Turcz.) Baill.) and its chemical contents on animal livers].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Lignans; Liver; Mitochondria, Liver; Polycyclic Compounds | 1988 |
Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases.
Topics: Aging; Animals; Antioxidants; Cyclooctanes; Hormesis; Humans; Lignans; Mitochondria; Oxidative Stress; Polycyclic Compounds; Qi; Reactive Oxygen Species; Schisandraceae | 2012 |
Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases.
Topics: Aging; Animals; Cyclooctanes; Hormesis; Lignans; Mitochondria; Neurodegenerative Diseases; Polycyclic Compounds; Protective Agents | 2012 |
Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease.
Topics: Animals; Cyclooctanes; Humans; Lignans; Models, Biological; Non-alcoholic Fatty Liver Disease; Polycyclic Compounds; Protective Agents | 2016 |
A Comprehensive Review on Schisandrin B and Its Biological Properties.
Topics: Cyclooctanes; Humans; Lignans; Medicine, Chinese Traditional; Polycyclic Compounds | 2020 |
294 other study(ies) available for schizandrin b and lignans
| Article | Year |
|---|---|
Effect of schisandrin B on lipoperoxidative damage to plasma membrane of rat liver in vitro.
Topics: Animals; Cell Membrane; Cyclooctanes; Lignans; Lipid Peroxidation; Liver; Malondialdehyde; Membrane Fluidity; NADP; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1992 |
Antioxidant activity of two dibenzocyclooctene lignans on the aged and ischemic brain in rats.
Topics: Adenosine Triphosphatases; Aging; Animals; Antioxidants; Brain; Brain Ischemia; Cyclooctanes; Drugs, Chinese Herbal; Free Radicals; Lignans; Lipid Peroxidation; Male; Mitochondrial Swelling; Polycyclic Compounds; Rats; Rats, Inbred Strains; Vitamin E | 1992 |
Effects of oxygen radicals on the conformation of sulfhydryl groups on human polymorphonuclear leukocyte membranes.
Topics: Cell Membrane; Cyclooctanes; Electron Spin Resonance Spectroscopy; Fluorometry; Free Radicals; Humans; Lignans; Lipid Peroxidation; Luminescent Measurements; Malondialdehyde; Membrane Proteins; Neutrophils; Oxygen; Polycyclic Compounds; Quercetin; Respiratory Burst; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate | 1991 |
Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity.
Topics: Animals; Catalase; Cyclooctanes; Cytosol; Ethanol; Gossypol; Lignans; Lignin; Lipid Peroxidation; Liver; Male; Malondialdehyde; Microsomes, Liver; NAD; Oxidation-Reduction; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains; Superoxide Dismutase; Superoxides | 1991 |
[Effects of schizandrin B and schisanhenol on drug metabolizing-phase II enzymes and estradiol metabolism].
Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Estradiol; Female; Glutathione Transferase; Lignans; Liver; Male; Mice; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1990 |
Scavenging effect of schizandrins on active oxygen radicals.
Topics: Cyclooctanes; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Lignans; Lymphocyte Activation; Molecular Structure; Neutrophils; Oximetry; Oxygen Consumption; Polycyclic Compounds; Tetradecanoylphorbol Acetate | 1990 |
[Determination of the active ingredients in Chinese drug wuweizi (Schisandra chinensis) by TLC-densitometry].
Topics: Chromatography, Thin Layer; Cyclooctanes; Densitometry; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds | 1990 |
Pharmacological actions and clinical use of fructus schizandrae.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Drugs, Chinese Herbal; Hepatitis B; Humans; Lignans; Lipid Peroxidation; Mice; Microsomes, Liver; Polycyclic Compounds; Rats | 1989 |
[Action of schizandrin B, an antioxidant, on lipid peroxidation in primary cultured hepatocytes].
Topics: Animals; Antioxidants; Cyclooctanes; Lignans; Lipid Peroxidation; Liver; Male; Malondialdehyde; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1989 |
[Effects of schizandrins and diphenyl dimethyl bicarboxylate on enzymes of liver smooth and rough endoplasmic reticula in rats].
Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Endoplasmic Reticulum; Lignans; Liver; Male; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1987 |
[Induction of hepatocyte microsomal cytochrome P-450 by Schizandrin B in mice (author's transl)].
Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxolanes; Dioxoles; DNA; Enzyme Induction; Lignans; Lipids; Liver; Liver Glycogen; Mice; Microsomes, Liver; Polycyclic Compounds; Proteins; RNA | 1980 |
[Effect of gamma-schisandrin on metabolism of DNA, ATP and nucleoprotein of cancer cells].
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cyclooctanes; DNA, Neoplasm; Lignans; Mice; Neoplasms, Experimental; Nucleoproteins; Polycyclic Compounds | 1984 |
Specific evidence that schizandrins induce a phenobarbital-like cytochrome P-450 form separated from rat liver.
Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxolanes; Dioxoles; Hydrocarbons, Chlorinated; Immunodiffusion; Lignans; Male; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1981 |
Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; In Vitro Techniques; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Microsomes, Liver; Mutagens; NADP; Oxidation-Reduction; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1982 |
Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids.
Topics: Animals; Carbon Tetrachloride; China; Cyclooctanes; Dioxoles; Lignans; Lipid Metabolism; Lipid Peroxides; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; NADP; Oxygen Consumption; Plants, Medicinal; Polycyclic Compounds | 1982 |
Effect of schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity.
Topics: Animals; Antioxidants; Carbon Tetrachloride Poisoning; Cyclooctanes; Female; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Lignans; Liver; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Plants, Medicinal; Polycyclic Compounds | 1995 |
[Quantitative analysis of gamma-schizandrin in manganbao granules, a complex prescription of Chinese medicine].
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Hepatitis B; Lignans; Polycyclic Compounds | 1995 |
Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride; Cyclooctanes; Enzyme Inhibitors; Female; Free Radicals; Glutathione; Glutathione Disulfide; Glutathione Reductase; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Oxidation-Reduction; Polycyclic Compounds | 1996 |
Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chlorides; Cyclooctanes; Erythrocyte Membrane; Female; Ferric Compounds; Humans; In Vitro Techniques; Lignans; Lipid Peroxidation; Liver; Membrane Lipids; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Vitamin E | 1996 |
The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene.
Topics: Alanine Transaminase; Animals; Antioxidants; Butylated Hydroxytoluene; Carbon Tetrachloride; Cyclooctanes; Female; Lignans; Liver; Mice; Mice, Inbred BALB C; NADP; Polycyclic Compounds | 1996 |
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Drugs, Chinese Herbal; Female; Glutathione; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Polycyclic Compounds; Structure-Activity Relationship | 1997 |
Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: effects of insulin and Schisandrin B treatment.
Topics: Alanine Transaminase; Animals; Antioxidants; Blood Glucose; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Diabetes Mellitus, Experimental; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Insulin; Lignans; Liver; Liver Diseases; Male; Microsomes; Mitochondria, Liver; Oxidation-Reduction; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Streptozocin | 1997 |
Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Cyclooctanes; Drugs, Chinese Herbal; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heart; In Vitro Techniques; L-Lactate Dehydrogenase; Lignans; Male; Molecular Conformation; Molecular Structure; Myocardial Reperfusion Injury; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 1999 |
Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists.
Topics: Biphenyl Compounds; Cyclooctanes; Esterification; Hydroxylation; Lignans; Plants, Medicinal; Platelet Activating Factor; Polycyclic Compounds; Structure-Activity Relationship | 1999 |
Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Glutathione; Glutathione Reductase; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Polycyclic Compounds; Structure-Activity Relationship | 1998 |
Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status.
Topics: Animals; Antioxidants; Cyclooctanes; Glutathione; Lignans; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 1999 |
Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Female; Glutathione; Glutathione Reductase; Hydrocarbons, Chlorinated; Insecticides; L-Iditol 2-Dehydrogenase; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Oxidation-Reduction; Oxidative Stress; Polycyclic Compounds | 2000 |
Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity.
Topics: Alanine Transaminase; Animals; Antioxidants; Cells, Cultured; Cyclooctanes; Drugs, Chinese Herbal; Enzyme Activation; Female; Hepatocytes; Lignans; Liver; Malondialdehyde; Mice; Mice, Inbred BALB C; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Vitamin K | 2000 |
[Chemical constituents of the stems and leaves of Trigonella foenum-graecum L].
Topics: Cyclooctanes; Drugs, Chinese Herbal; Fabaceae; Lignans; Molecular Structure; Plant Leaves; Plant Stems; Plants, Medicinal; Polycyclic Compounds; Scopoletin | 1997 |
Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts.
Topics: Animals; Antioxidants; Ascorbic Acid; Cyclooctanes; Female; Heart; L-Lactate Dehydrogenase; Lignans; Male; Models, Chemical; Myocardium; Oxidative Stress; Perfusion; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioctic Acid; Time Factors | 2001 |
Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver.
Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Cyclooctanes; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Lignans; Liver; Liver Diseases; Mice; Polycyclic Compounds; Tumor Necrosis Factor-alpha | 2001 |
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Avoidance Learning; Behavior, Animal; Cognition; Cyclooctanes; Dose-Response Relationship, Drug; Fruit; Lignans; Liver; Male; Mice; Mice, Inbred ICR; Plant Extracts; Polycyclic Compounds; Schisandraceae; Tacrine | 2002 |
Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain.
Topics: Animals; Antioxidants; Brain; Cyclooctanes; Glutathione; Lignans; Mice; Molecular Structure; Oxidative Stress; Polycyclic Compounds; Protective Agents; tert-Butylhydroperoxide; Time Factors | 2002 |
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Emodin; Female; Fruit; Glutathione; L-Iditol 2-Dehydrogenase; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Phytotherapy; Plant Extracts; Plant Roots; Polycyclic Compounds; Polygonum; Random Allocation; Schisandra | 2002 |
[Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera].
Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Cyclooctanes; Fruit; Lignans; Plants, Medicinal; Polycyclic Compounds; Schisandra | 2001 |
Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Carbon Tetrachloride; Cyclooctanes; Dioxoles; Enzyme Inhibitors; Female; Free Radicals; Glutathione; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Lignans; Liver; Mice; Mice, Inbred BALB C; Mitochondria; Models, Chemical; Molecular Chaperones; Neoplasm Proteins; Oxidative Stress; Polycyclic Compounds; Time Factors | 2003 |
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice.
Topics: Analysis of Variance; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cyclooctanes; Female; Glutathione; Heat-Shock Proteins; Lignans; Liver; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Polycyclic Compounds; Time Factors | 2003 |
Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Cyclooctanes; Female; Glutathione; Heart; Lignans; Mitochondria, Heart; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors | 2003 |
Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Glutamic Acid; Intracellular Fluid; Lignans; Neurons; Neuroprotective Agents; Neurotoxins; Peroxides; Phytotherapy; Plant Extracts; Polycyclic Compounds; Rats; Schisandra | 2004 |
Determination of specific receptor sites for platelet activating factor in bovine neutrophils.
Topics: Animals; Azepines; Base Sequence; Blotting, Western; Cattle; Cyclooctanes; Diterpenes; DNA Primers; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Ginkgolides; HL-60 Cells; Humans; Kinetics; Lactones; Lignans; Molecular Sequence Data; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polycyclic Compounds; Radioligand Assay; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Triazoles; Tritium | 2004 |
Antioxidative effect of schisanhenol on human low density lipoprotein and its quantum chemical calculation.
Topics: alpha-Tocopherol; Animals; Antioxidants; Copper; Cyclooctanes; Drugs, Chinese Herbal; Free Radical Scavengers; Humans; Lignans; Lipid Peroxidation; Lipofuscin; Lipoproteins, LDL; Male; Malondialdehyde; Microsomes, Liver; Oxidation-Reduction; Polycyclic Compounds; Rats; Rats, Wistar; Reactive Oxygen Species | 2004 |
Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Cell Differentiation; Cell Proliferation; Cyclooctanes; Down-Regulation; Flow Cytometry; HSP70 Heat-Shock Proteins; Humans; Lignans; Liver Neoplasms; Polycyclic Compounds; Tumor Cells, Cultured; Up-Regulation | 2004 |
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats.
Topics: Animals; Cardiotonic Agents; Cyclooctanes; Female; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Lignans; Myocardial Reperfusion Injury; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra | 2004 |
[Study on the simultaneous spectrophotometric determination of three components including deoxyschizandrin by ridge regression method].
Topics: Cyclooctanes; Lignans; Polycyclic Compounds; Regression Analysis; Spectrophotometry | 2004 |
Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography.
Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Cyclooctanes; Fruit; Lignans; Polycyclic Compounds; Schisandra; Solvents | 2005 |
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.
Topics: Administration, Oral; Animals; Antioxidants; Cyclooctanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Heat-Shock Response; Lignans; Liver; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mitochondria, Liver; NADP; Oxidative Stress; Polycyclic Compounds; Schisandraceae; Triazoles | 2005 |
Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis.
Topics: Cyclooctanes; Drugs, Chinese Herbal; Electrophoresis, Capillary; Lignans; Polycyclic Compounds; Reproducibility of Results; Schisandra; Seeds; Temperature | 2005 |
Schisandrin B--a novel inhibitor of P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; Models, Chemical; Neoplasms; Polycyclic Compounds; Protein Binding; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells.
Topics: Animals; Cell Line; Cyclooctanes; Female; Gene Expression Regulation; Glutathione; Heat-Shock Proteins; In Vitro Techniques; Lignans; Mitochondria, Liver; Molecular Structure; Myocardial Reperfusion Injury; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2005 |
[Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene].
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cyclooctanes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Genes, MDR; Humans; Lignans; Polycyclic Compounds | 2005 |
Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Daunorubicin; Dioxoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; Paclitaxel; Polycyclic Compounds; Prohibitins; Vincristine | 2006 |
Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Caspases; Cell Line, Tumor; Cells, Cultured; Cyclooctanes; DNA Primers; Doxorubicin; Drug Synergism; Flow Cytometry; Humans; Lignans; Polycyclic Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclooctanes; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Lignans; Molecular Structure; Multidrug Resistance-Associated Proteins; Polycyclic Compounds; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
A novel experimental model of acute hypertriglyceridemia induced by schisandrin B.
Topics: Animals; Cyclooctanes; Disease Models, Animal; Fenofibrate; Hypertriglyceridemia; Hypolipidemic Agents; Lignans; Lipids; Liver; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds | 2006 |
Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats.
Topics: Aging; Animals; Antioxidants; Cyclooctanes; Female; Heat-Shock Proteins; Lignans; Mitochondria; Organ Specificity; Oxygen; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tissue Distribution | 2006 |
Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes.
Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Cyclooctanes; Glutamate-Cysteine Ligase; Glutathione; Glutathione Reductase; Hepatocytes; L-Lactate Dehydrogenase; Lignans; Mice; Polycyclic Compounds; Vitamin K 3 | 2006 |
(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes.
Topics: Animals; Cell Death; Cells, Cultured; Cyclooctanes; Glutathione; HSP70 Heat-Shock Proteins; Lignans; Myocytes, Cardiac; Oxidants; Polycyclic Compounds; Rats; Stereoisomerism; Time Factors; Xanthine; Xanthine Oxidase | 2006 |
Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver.
Topics: Animals; Antioxidants; Catalysis; Cyclooctanes; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Female; Glutathione; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Lignans; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes, Liver; Mitochondria, Liver; Molecular Chaperones; NADP; Neoplasm Proteins; Polycyclic Compounds | 2006 |
Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells.
Topics: Animals; Antifibrinolytic Agents; Antineoplastic Agents, Alkylating; Buthionine Sulfoximine; Carmustine; Cyclooctanes; Cysteine; Cytoprotection; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Reductase; L-Lactate Dehydrogenase; Lignans; Mice; Oxidants; Oxidation-Reduction; Polycyclic Compounds; Vitamin K 3 | 2006 |
[Gamma-Schisandrin inhibits production of amyloid beta-protein 42 in M146L cells].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclooctanes; Dose-Response Relationship, Drug; Humans; Lignans; Peptide Fragments; Polycyclic Compounds | 2006 |
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane Permeability; Cyclooctanes; Cytochromes c; Female; Ions; Lignans; Membrane Potentials; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Molecular Structure; Polycyclic Compounds; Reactive Oxygen Species; Time Factors | 2007 |
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts.
Topics: Animals; Calcium; Cardiotonic Agents; Cyclooctanes; Cytochromes c; Fruit; Lignans; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Plants, Medicinal; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Schisandra | 2007 |
Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling.
Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Cyclooctanes; Doxorubicin; Glutathione; Heart Diseases; Lignans; Mice; Mice, Inbred ICR; Oxidation-Reduction; Polycyclic Compounds | 2007 |
Inhibitory effect of schisandrin B on gastric cancer cells in vitro.
Topics: Astragalus Plant; Cell Cycle; Cell Line, Tumor; Cyclin D1; Cyclooctanes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Emodin; Glucosides; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Lignans; Medicine, Chinese Traditional; Mitosis; Polycyclic Compounds; Polysaccharides; RNA, Messenger; Stomach Neoplasms; Time Factors | 2007 |
Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclooctanes; Dioxoles; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fruit; Genes, MDR; Humans; Lignans; Mice; Mice, Nude; Neoplasm Proteins; Phytotherapy; Plant Preparations; Polycyclic Compounds; Protein Kinase C; Schisandra; Xenograft Model Antitumor Assays | 2008 |
Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Cyclooctanes; Diffusion; Dioxoles; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Lignans; Medicine, Chinese Traditional; Models, Biological; Multidrug Resistance-Associated Proteins; Permeability; Plant Extracts; Polycyclic Compounds; Schisandra | 2008 |
Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholesterol, Dietary; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Fenofibrate; Hypercholesterolemia; Hypolipidemic Agents; Lignans; Liver; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Schisandra; Triglycerides | 2008 |
Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antioxidants; Ascorbic Acid; Cyclooctanes; Female; Gentamicins; Glutathione; Kidney; Kidney Diseases; Lignans; Mitochondria; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2008 |
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes.
Topics: Annexin A5; Apoptosis; Calcium; Caspase 3; Cell Hypoxia; Cell Line; Cyclooctanes; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glutathione; Humans; Lignans; Membrane Potentials; Mitochondria, Heart; Mitochondrial Membranes; Myocytes, Cardiac; Permeability; Poly(ADP-ribose) Polymerases; Polycyclic Compounds; Stereoisomerism | 2008 |
Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Area Under Curve; Brain Ischemia; Cyclooctanes; Female; Fruit; Glutathione; Lignans; Malondialdehyde; Mitochondria; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Schisandra; Superoxide Dismutase | 2008 |
Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.
Topics: Alkaline Phosphatase; Animals; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Cyclooctanes; Enzyme Activators; Lignans; Osteoblasts; Plant Extracts; Polycyclic Compounds; Rats; Schisandra | 2009 |
[Lignans from different processed products of Schisandra chinensis fruits].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drug Compounding; Drugs, Chinese Herbal; Fruit; Hot Temperature; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra; Spectrometry, Mass, Electrospray Ionization | 2008 |
Effect of schisandrin B and sesamin mixture on CCl(4)-induced hepatic oxidative stress in rats.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drug Combinations; Drugs, Chinese Herbal; Glutathione; Glutathione Peroxidase; Lignans; Liver; Liver Diseases; Male; Oxidative Stress; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Silymarin; Superoxide Dismutase | 2009 |
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in the Ca(2+)-induced mitochondrial permeability transition and mitochondrial membrane potential in AML12 hepatocytes.
Topics: Animals; Apoptosis; Caspase 3; Cell Hypoxia; Cell Line; Cyclooctanes; Cytochromes c; Glutathione; Hepatocytes; Lignans; Membrane Potential, Mitochondrial; Mice; Molecular Structure; Poly(ADP-ribose) Polymerases; Polycyclic Compounds | 2009 |
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Survival; Cyclooctanes; DNA Damage; Humans; Lignans; MAP Kinase Signaling System; Phosphorylation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Signal Transduction; Ultraviolet Rays | 2009 |
Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Cerebral Cortex; Cyclooctanes; Cytochromes c; Glutathione; Lignans; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Peptide Fragments; Polycyclic Compounds; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar | 2009 |
Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytoprotection; Heat-Shock Proteins; Lignans; Male; Mercuric Chloride; Polycyclic Compounds; Rats; Rats, Wistar | 2009 |
[Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds; Schisandra | 2009 |
Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract.
Topics: Antioxidants; Chemical Fractionation; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Plant Extracts; Polycyclic Compounds; Pressure; Schisandra | 2009 |
Highly sensitive determination of Schisandrin and Schisandrin B in plasma of rats after administration of Wurenchun (Fructus Schisandrae Chinensis Extracts) preparations by LC-ESI-MS/MS.
Topics: Animals; Chromatography, Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice.
Topics: Aging; Animals; Antioxidants; Brain; Cyclooctanes; Dietary Supplements; Female; Glutathione; Heart; Kidney; Lignans; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Polycyclic Compounds; Superoxide Dismutase | 2008 |
Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Cell Proliferation; Cell Survival; Cyclin D1; Cyclooctanes; Cytochromes c; Dioxoles; DNA Fragmentation; Flow Cytometry; Fruit; G1 Phase; Humans; Lignans; Mitochondria; Polycyclic Compounds; Schisandra; U937 Cells | 2010 |
Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooctanes; Fruit; Lignans; Macrophages; Mice; Polycyclic Compounds; Schisandra | 2010 |
A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera.
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Lignans; Mass Spectrometry; Plant Extracts; Polycyclic Compounds; Reproducibility of Results; Schisandra | 2010 |
[Research on liposoluble ingredients of Quchiling].
Topics: Allylbenzene Derivatives; Animals; Anisoles; Brain; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Gas Chromatography-Mass Spectrometry; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2010 |
[Changes of lignans' content in stems of Schisandra chinensis].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Plant Stems; Polycyclic Compounds; Schisandra | 2009 |
[Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits].
Topics: Animals; Apoptosis; Cardiomyopathies; Cyclooctanes; Doxorubicin; Female; Lignans; Lipid Peroxidation; Male; Natriuretic Peptide, Brain; Polycyclic Compounds; Rabbits; Random Allocation; Reactive Oxygen Species; Schisandraceae; Superoxide Dismutase; Troponin I | 2010 |
Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inhibitory Concentration 50; Lignans; Male; Microsomes, Liver; Midazolam; Polycyclic Compounds; Rats; Rats, Wistar; Time Factors | 2010 |
Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antioxidants; Cardiovascular Agents; Cyclooctanes; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Female; Glutathione; Lignans; Microsomes; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NADP; Oxidation-Reduction; Phytotherapy; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Schisandra | 2010 |
Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cyclooctanes; Dioxoles; Homocysteine; Lignans; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Polycyclic Compounds; Rats; Reactive Oxygen Species; Schisandra | 2011 |
Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats.
Topics: Animals; Antioxidants; Brain; Cyclooctanes; Ethanol; Female; Heart; Kidney; Lignans; Liver; Mitochondria; Molecular Structure; Organ Specificity; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2010 |
A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms.
Topics: Cyclooctanes; Dioxoles; Eleutherococcus; Furans; Lignans; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Triterpenes | 2010 |
Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Cyclooctanes; Drug Delivery Systems; Drugs, Chinese Herbal; Emulsions; Excipients; Fruit; Lignans; Male; Particle Size; Plant Extracts; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Solubility | 2010 |
[Effect of Schisandrin B on mitogen-activated protein kinases and nuclear factor-kappaB in rat lungs exposed to silica].
Topics: Animals; Cyclooctanes; Female; Lignans; Lung; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Polycyclic Compounds; Rats; Rats, Wistar; Signal Transduction; Silicon Dioxide | 2010 |
[Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Cyclooctanes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Duodenum; Fruit; Ileum; Intestinal Absorption; Jejunum; Lignans; Male; Perfusion; Permeability; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra | 2010 |
Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.
Topics: alpha-Tocopherol; Animals; Antioxidants; Cyclooctanes; Cytochrome P-450 Enzyme System; Glutathione; Lignans; Malondialdehyde; Oxidative Stress; Phytotherapy; Plant Extracts; Polycyclic Compounds; Radiation Injuries; Rats; Rats, Sprague-Dawley; Schisandra; Skin; Sunlight | 2011 |
A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.
Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Electrophoresis, Gel, Two-Dimensional; Extracellular Signal-Regulated MAP Kinases; Lignans; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred BALB C; Phosphatidylethanolamine Binding Protein; Polycyclic Compounds; Protective Agents; Proteins; Proteome; Proteomics; Proto-Oncogene Proteins c-raf; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Statistics, Nonparametric | 2011 |
Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Cyclooctanes; Down-Regulation; Drug Evaluation, Preclinical; Drug Synergism; ErbB Receptors; HeLa Cells; Humans; Lignans; Models, Biological; NF-kappa B; Polycyclic Compounds; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells.
Topics: Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Cell Line; Cyclooctanes; Cytoprotection; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Gene Knockdown Techniques; Glutathione; Lignans; NF-E2-Related Factor 2; Oxidation-Reduction; Polycyclic Compounds; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction | 2011 |
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes.
Topics: Animals; Antioxidants; Apoptosis; Butadienes; Carbon Tetrachloride; Cell Line; Cyclooctanes; Cytoprotection; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Glutathione; Hepatocytes; Lignans; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Nitriles; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Polycyclic Compounds; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Vitamin K 3 | 2011 |
[Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
Topics: Animals; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hepatocytes; Inhibitory Concentration 50; Lignans; Male; Microsomes, Liver; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schisandra | 2010 |
Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts.
Topics: Cells, Cultured; Cyclooctanes; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Fibroblasts; Glutathione; Humans; Lignans; Matrix Metalloproteinase 1; Peptide Hydrolases; Phytotherapy; Plant Extracts; Polycyclic Compounds; Radiation Injuries; Reactive Oxygen Species; Schisandra; Sunlight | 2011 |
The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury.
Topics: Animals; Apoptosis; Cyclooctanes; Female; Kidney; Lignans; Male; Mercury; Polycyclic Compounds; Polyphenols; Rats; Rats, Wistar; Reactive Oxygen Species; Tea | 2011 |
Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.
Topics: Animals; Anti-Allergic Agents; Bone Marrow Cells; Calcimycin; Calcium Ionophores; Carcinogens; Cells, Cultured; Cyclooctanes; Gene Expression Regulation; Hypersensitivity; Inflammation; Inflammation Mediators; Interleukin-6; Lignans; Male; Mast Cells; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Tetradecanoylphorbol Acetate | 2011 |
Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate.
Topics: Animals; Cholesterol; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Fenofibrate; Hypertriglyceridemia; Hypolipidemic Agents; Lignans; Liver; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Schisandra; Triglycerides | 2011 |
Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds | 2011 |
Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice.
Topics: Acetylcholinesterase; Animals; Antioxidants; Cyclooctanes; Lignans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred BALB C; Oxidative Stress; Polycyclic Compounds; Schisandra; Scopolamine | 2011 |
Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro.
Topics: Animals; Cell Line; Cyclooctanes; Cytochromes c; Dose-Response Relationship, Drug; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Kidney Cortex; Kidney Diseases; Kidney Tubules, Proximal; Lignans; Male; Membrane Proteins; Mercuric Chloride; Mitochondria; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Polycyclic Compounds; Rats; Rats, Wistar | 2011 |
Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cyclooctanes; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Humans; Lignans; Lipid Metabolism; Liver; Membrane Proteins; Perilipin-2; Polycyclic Compounds; Sterol Regulatory Element Binding Protein 1; Treatment Outcome; Up-Regulation | 2011 |
[Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica].
Topics: Animals; Cyclooctanes; Female; Lignans; Lung; Male; Polycyclic Compounds; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Silicosis; Smad4 Protein; Transforming Growth Factor beta1 | 2011 |
Prevention and treatment of doxorubicin-induced cardiotoxicity by dexrazoxane and schisandrin B in rabbits.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cardiotonic Agents; Cyclooctanes; Doxorubicin; Female; Heart Diseases; Lignans; Male; Malondialdehyde; Natriuretic Peptide, Brain; Polycyclic Compounds; Rabbits; Razoxane; Superoxide Dismutase; Troponin I | 2011 |
Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Antioxidants; Behavior, Animal; Brain; Caspase 3; Cisplatin; Cyclooctanes; DNA Damage; Drug Interactions; Lignans; Male; Mice; Mice, Inbred BALB C; Motor Skills; Mutagenicity Tests; NF-kappa B; Oxidative Stress; Polycyclic Compounds; Tumor Suppressor Protein p53 | 2012 |
Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes.
Topics: Animals; Catalysis; Cyclooctanes; Cytochrome P-450 Enzyme System; Glutathione; Heat-Shock Response; Hepatocytes; Lignans; Mice; Polycyclic Compounds; Reactive Oxygen Species | 2012 |
Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways.
Topics: Animals; Cell Line; Cyclooctanes; Lignans; Mitogen-Activated Protein Kinases; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2012 |
Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Glutathione; Heart; Heart Ventricles; Lignans; Male; Mice; Mice, Inbred BALB C; Myocardium; Oxidation-Reduction; Oxidative Stress; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2011 |
Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5.
Topics: Apoptosis; Cell Line, Tumor; Cyclooctanes; HeLa Cells; Humans; Lignans; Polycyclic Compounds; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2012 |
Enrichment and purification of deoxyschizandrin and γ-schizandrin from the extract of Schisandra chinensis fruit by macroporous resins.
Topics: Adsorption; Cyclooctanes; Fruit; Lignans; Polycyclic Compounds; Resins, Synthetic; Schisandra | 2012 |
Prooxidant-induced glutathione antioxidant response in vitro and in vivo: a comparative study between schisandrin B and curcumin.
Topics: Animals; Antioxidants; Carbon Tetrachloride Poisoning; Cell Line; Curcumin; Cyclooctanes; Female; Glutathione; Lignans; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Microsomes, Liver; Polycyclic Compounds; Reactive Oxygen Species; Vitamin E; Vitamin K 3 | 2012 |
[Effect of schizandrin B on H(2)O(2)-induced apoptosis of human hepatocytes in vitro: role of Fas pathway].
Topics: Apoptosis; Caspase 8; Cell Line; Cyclooctanes; fas Receptor; Fas-Associated Death Domain Protein; Flow Cytometry; Hepatocytes; Humans; Hydrogen Peroxide; Lignans; Polycyclic Compounds; Signal Transduction | 2012 |
Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia.
Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Death; Coculture Techniques; Cyclooctanes; Dinoprostone; Down-Regulation; Enzyme Activation; I-kappa B Kinase; Interleukin-1beta; Interleukin-6; Lignans; Lipopolysaccharides; Male; Mice; Microglia; Myeloid Differentiation Factor 88; NADPH Oxidases; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2012 |
Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Cell Survival; Creatinine; Cyclooctanes; Cyclosporine; Enzyme Inhibitors; Fruit; Glutathione; Humans; Kidney; Kidney Diseases; L-Lactate Dehydrogenase; Lignans; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Oxidative Stress; Phytotherapy; Plant Extracts; Polycyclic Compounds; Reactive Oxygen Species; Schisandra | 2012 |
Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Concanavalin A; Cyclooctanes; Cytokines; Gene Expression Regulation; Heme Oxygenase-1; I-kappa B Kinase; Lignans; Lymphocyte Activation; Lymphocytes; Male; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; NF-kappa B; Oxidation-Reduction; Polycyclic Compounds; Proto-Oncogene Proteins p21(ras); Signal Transduction; Spleen | 2012 |
Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.
Topics: Animals; Antioxidants; Cerebral Infarction; Cyclooctanes; Drugs, Chinese Herbal; Inflammation; Interleukin-1beta; Ischemic Attack, Transient; Lignans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuroprotective Agents; Plant Extracts; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reperfusion; Schisandra; Tumor Necrosis Factor-alpha | 2012 |
[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra | 2012 |
Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells.
Topics: Apoptosis; beta Catenin; Cell Cycle Checkpoints; Cell Proliferation; Cyclin D1; Cyclooctanes; G1 Phase; HCT116 Cells; Humans; Lignans; Polycyclic Compounds; Regulatory Sequences, Nucleic Acid; Resting Phase, Cell Cycle; TCF Transcription Factors; Transcription, Genetic; Wnt Proteins | 2012 |
Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Cyclooctanes; Dose-Response Relationship, Drug; Hepatocytes; Lignans; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Polycyclic Compounds; Rats; Rats, Wistar; Schisandra; Structure-Activity Relationship | 2013 |
Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2013 |
Lipidomics identification of metabolic biomarkers in chemically induced hypertriglyceridemic mice.
Topics: Animals; Biomarkers; Calibration; Chromatography, Liquid; Cyclooctanes; Hypertriglyceridemia; Lignans; Lipids; Mice; Polycyclic Compounds; Principal Component Analysis; Reproducibility of Results; Tandem Mass Spectrometry; Triglycerides | 2013 |
[Schisandrin B protects against nephrotoxicity induced by cisplatin in HK-2 cells via Nrf2-ARE activation].
Topics: Antineoplastic Agents; Antioxidants; Cell Line; Cell Survival; Cisplatin; Cyclooctanes; Glutamate-Cysteine Ligase; Glutathione; Heme Oxygenase-1; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Lignans; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Polycyclic Compounds; Reactive Oxygen Species; RNA, Messenger; Schisandra; Signal Transduction; Superoxide Dismutase | 2012 |
Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Medicine, Chinese Traditional; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Sensitivity and Specificity; Sleep Initiation and Maintenance Disorders; Tandem Mass Spectrometry | 2013 |
Effect of acupuncture on target tissue distribution of Schisandra lignans.
Topics: Acupuncture Therapy; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Polycyclic Compounds; Rats; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Tissue Distribution | 2013 |
Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Cyclooctanes; Lignans; Polycyclic Compounds; Rats; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Tissue Distribution | 2013 |
In vivo effect of Schisandrin B on cytochrome P450 enzyme activity.
Topics: Administration, Oral; Animals; Biological Availability; Cyclooctanes; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Ketoconazole; Lignans; Liver; Male; Medicine, Chinese Traditional; Microsomes, Liver; Midazolam; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2013 |
Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine).
Topics: Cell Differentiation; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Methanol; Plant Shoots; Polycyclic Compounds; Schisandra; Sonication | 2013 |
Inhibiting cancer metastasis via targeting NAPDH oxidase 4.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cyclooctanes; Female; Humans; Lignans; Mice; Mice, Inbred BALB C; Microscopy, Confocal; NADPH Oxidase 4; NADPH Oxidases; Neoplasm Metastasis; Polycyclic Compounds; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta | 2013 |
Differential effect of schisandrin B stereoisomers on ATR-mediated DNA damage checkpoint signaling.
Topics: Ataxia Telangiectasia Mutated Proteins; Cells, Cultured; Cyclooctanes; DNA Damage; Dose-Response Relationship, Drug; Genes, cdc; Humans; Lignans; Polycyclic Compounds; Signal Transduction; Stereoisomerism; Structure-Activity Relationship | 2013 |
Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; Microsomes, Liver; Plants, Medicinal; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2013 |
Ultrasound-assisted extraction and purification of schisandrin B from Schisandra chinensis (Turcz.) Baill seeds: optimization by response surface methodology.
Topics: Chemical Fractionation; Crystallization; Cyclooctanes; Lignans; Models, Statistical; Pilot Projects; Polycyclic Compounds; Schisandra; Seeds; Statistics as Topic; Ultrasonics | 2014 |
Novel mouse model of combined hyperlipidemia associated with steatosis and liver injury by a single-dose intragastric administration of schisandrin B/cholesterol/bile salts mixture.
Topics: Administration, Oral; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholesterol; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Fenofibrate; Hyperlipidemias; Lignans; Lipoproteins; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Time Factors; Triglycerides | 2013 |
Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro.
Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Cycle; Cell Line; Cell Survival; Cisplatin; Collagen; Cyclooctanes; Epithelial Cells; Fruit; Humans; Kidney Tubules, Proximal; Lignans; Molecular Structure; Polycyclic Compounds; Protective Agents; Schisandra | 2014 |
In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus.
Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tablets; Tacrolimus | 2014 |
Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cyclic AMP-Dependent Protein Kinases; Cyclooctanes; Dioxoles; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mice, Inbred ICR; Microglia; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Polycyclic Compounds; Reactive Oxygen Species; STAT Transcription Factors; Toll-Like Receptor 2 | 2014 |
Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Lignans; Liver; Male; Mice; Phytotherapy; Polycyclic Compounds; Schisandra; Time Factors | 2014 |
Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction.
Topics: Animals; Apoptosis; Cell Line; Cyclooctanes; Fruit; Humans; Lignans; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Polycyclic Compounds; Rats; Schisandra | 2013 |
Screening of herbal components for attenuating amiodarone-induced hepatotoxicity on gel-entrapped rat hepatocytes.
Topics: Alkaloids; Amiodarone; Analysis of Variance; Animals; Cyclooctanes; Drug Discovery; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Glycyrrhizic Acid; Hepatocytes; Lignans; Matrines; Polycyclic Compounds; Quinolizines; Rats; Silybin; Silymarin; Solanaceous Alkaloids | 2014 |
Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis).
Topics: Acupuncture Therapy; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Linear Models; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution | 2014 |
Schisandrin B suppresses TGFβ1-induced stress fiber formation by inhibiting myosin light chain phosphorylation.
Topics: Actins; Animals; Cell Movement; Cells, Cultured; Cyclooctanes; Fruit; Lignans; Medicine, East Asian Traditional; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylation; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Signal Transduction; Smad Proteins; Stress Fibers; Transforming Growth Factor beta1 | 2014 |
Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
Topics: Animals; Behavior, Animal; Cyclooctanes; Disease Models, Animal; Drug Synergism; Flumazenil; Fruit; GABA Agents; Hypnotics and Sedatives; Lignans; Male; Mice; Pentobarbital; Polycyclic Compounds; Schisandra; Serotonin Agents; Sleep; Sleep Initiation and Maintenance Disorders | 2014 |
Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.
Topics: Berberine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coumarins; Cyclooctanes; Cyclopentanes; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Furans; Ginkgolides; Hep G2 Cells; Humans; Isoflavones; Kinetics; Lignans; Luteolin; Phytochemicals; Polycyclic Compounds | 2014 |
Reversing effects of lignans on CCl4-induced hepatic CYP450 down regulation by attenuating oxidative stress.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Down-Regulation; Hep G2 Cells; Humans; Lignans; Liver; Liver Diseases; Male; Oxidative Stress; Plant Extracts; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra | 2014 |
[Determination of five components in rongxin pills by HPLC].
Topics: Abietanes; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Linear Models; Organic Chemicals; Phenanthrenes; Polycyclic Compounds; Quality Control; Reproducibility of Results | 2014 |
Schisandrin A and B affect subventricular zone neurogenesis in mouse.
Topics: Animals; Cell Proliferation; Cell Survival; Cyclooctanes; Lateral Ventricles; Lignans; Male; Mice; Neurogenesis; Neurons; Olfactory Bulb; Polycyclic Compounds | 2014 |
[Effect of forchlorfenuron on fruit morphology and lignans content of Schisandra chinensis].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Fruit; Lignans; Phenylurea Compounds; Polycyclic Compounds; Pyridines | 2014 |
Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (-)-gomisin N in human tumour cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooctanes; Fruit; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Schisandra | 2014 |
Schisandrin B induces apoptosis and cell cycle arrest of gallbladder cancer cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Proliferation; Cyclooctanes; Gallbladder Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Lignans; Membrane Potential, Mitochondrial; Mice; Neoplasm Proteins; NF-kappa B; Polycyclic Compounds | 2014 |
[Prevention against and treatment of doxorubicin-induced acute cardiotoxicity by dexrazoxane and schisandrin B].
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Cardiomyopathies; Cardiotoxicity; Cyclooctanes; Dexrazoxane; Doxorubicin; Heart; Lignans; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2014 |
Hepatoprotective effect of Schisandra chinensis (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Lignans; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred ICR; Plant Extracts; Polycyclic Compounds; Rubus; Schisandra | 2014 |
Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice.
Topics: Administration, Oral; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dose-Response Relationship, Drug; Lignans; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Molecular Structure; Plant Oils; Polycyclic Compounds; Schisandra; Time Factors; Triglycerides | 2014 |
Identification of key structural characteristics of Schisandra chinensis lignans involved in P-glycoprotein inhibition.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cyclooctanes; Doxorubicin; G2 Phase Cell Cycle Checkpoints; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Quantitative Structure-Activity Relationship; Russia; Schisandra; Seeds | 2014 |
Antioxidative effects of schidandrin B and green tea polyphenols against mercuric chloride-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclooctanes; Lignans; Liver; Mercuric Chloride; Oxidative Stress; Polycyclic Compounds; Polyphenols; Random Allocation; Rats; Rats, Wistar; Tea | 2014 |
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Resistance, Multiple, Viral; Drugs, Chinese Herbal; Fruit; HIV Reverse Transcriptase; HIV-1; Lignans; Mutation; Polycyclic Compounds; Reverse Transcriptase Inhibitors; Schisandra; Virus Replication | 2015 |
Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiomyopathies; Cyclooctanes; Disease Models, Animal; Doxorubicin; Gene Expression Regulation; Lignans; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Tyrosine; Ventricular Function, Left | 2015 |
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dioxoles; Lignans; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Polycyclic Compounds; Protective Agents; Schisandra | 2015 |
Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases.
Topics: Animals; Apoptosis; Cell Survival; Cyclooctanes; Lignans; Neurodegenerative Diseases; Oxidative Stress; PC12 Cells; Polycyclic Compounds; Rats; Reactive Oxygen Species; Signal Transduction | 2015 |
Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers.
Topics: Animals; Cyclooctanes; Diet, High-Fat; Disease Models, Animal; Fasting; Fatty Acid Synthases; Fatty Acids; Lignans; Lipid Metabolism; Lipids; Lipolysis; Liver; Liver Cirrhosis; Male; Metabolic Networks and Pathways; Metabolomics; Mice; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Palmitic Acid; Polycyclic Compounds; Sterol Regulatory Element Binding Protein 1; Tumor Necrosis Factor-alpha | 2015 |
Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.
Topics: Administration, Oral; Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Kidney; Lignans; Liver; Liver Cirrhosis; Male; Polycyclic Compounds; Rats; Rats, Wistar; Tissue Distribution | 2015 |
[Study on chemical constituents from Schisandra chinensis stem].
Topics: Cyclooctanes; Guaiacol; Lignans; Phytochemicals; Plant Stems; Polycyclic Compounds; Schisandra; Sitosterols | 2014 |
Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity.
Topics: Animals; Apoptosis; Autophagy; Cell Cycle; Cell Division; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cyclooctanes; G1 Phase; Hepatocytes; Lignans; Macrophages; Mice; Mitochondria, Liver; Polycyclic Compounds; S Phase; Signal Transduction | 2015 |
Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis.
Topics: Anti-Bacterial Agents; Bacteria; Cell Line; Chlamydia Infections; Chlamydia trachomatis; Chlamydophila pneumoniae; Cyclooctanes; Humans; Lignans; Microbial Sensitivity Tests; Polycyclic Compounds; Reactive Oxygen Species; Schisandra | 2015 |
The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damages in vitro.
Topics: Antioxidant Response Elements; Benzo(a)pyrene; Cell Line; Cyclooctanes; Cytoprotection; Female; Humans; Lignans; NF-E2-Related Factor 2; Polycyclic Compounds; RNA, Small Interfering; Signal Transduction; Trophoblasts | 2016 |
Schisandrin A and B induce organic anion transporting polypeptide 1B1 transporter activity.
Topics: Abietanes; Cell Line, Tumor; Cyclooctanes; Estrone; Humans; Lignans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Plants, Medicinal; Polycyclic Compounds; RNA, Messenger | 2015 |
The Protecting Effect of Deoxyschisandrin and Schisandrin B on HaCaT Cells against UVB-Induced Damage.
Topics: Antioxidants; Apoptosis; Caspases; Cell Line; Cell Survival; Cyclooctanes; Cytoprotection; DNA Damage; Humans; Keratinocytes; Lignans; Polycyclic Compounds; Reactive Oxygen Species; Schisandra; Ultraviolet Rays | 2015 |
[Chemical constituents from supercritical CO2 extraction of Schisandra chinensis].
Topics: Cyclooctanes; Lignans; Phytochemicals; Polycyclic Compounds; Schisandra; Sitosterols | 2014 |
Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson's disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway.
Topics: 3' Untranslated Regions; Animals; Behavior, Animal; Binding Sites; Brain; Cell Line, Tumor; Cell Survival; Cyclooctanes; Disease Models, Animal; Humans; Lignans; Male; Mice, Inbred C57BL; MicroRNAs; Motor Activity; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidopamine; Parkinsonian Disorders; Polycyclic Compounds; Signal Transduction; Transfection | 2015 |
Schisandrin B suppresses glioma cell metastasis mediated by inhibition of mTOR/MMP-9 signal pathway.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cyclooctanes; Dose-Response Relationship, Drug; Glioma; Humans; Lignans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Suppression of MAPK and NF-κ B pathways by schisandrin B contributes to attenuation of DSS-induced mice model of inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooctanes; Cytokines; Dextran Sulfate; Female; Inflammatory Bowel Diseases; Lignans; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Polycyclic Compounds; Signal Transduction | 2015 |
Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression.
Topics: Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Avoidance Learning; Beclin-1; Brain; Cyclooctanes; Heat-Shock Proteins; Infusions, Intraventricular; Lignans; Lipid Peroxidation; Male; Mitogen-Activated Protein Kinases; Neurons; NF-kappa B; Oxidative Stress; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Signal Transduction; Up-Regulation | 2015 |
Heat shock proteins 27 and 70 contribute to the protection of Schisandrin B against d-galactosamine-induced liver injury in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclooctanes; Galactosamine; Gene Expression; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Lignans; Liver; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Protective Agents; Quercetin; Schisandra | 2016 |
Suppression of P2X7/NF-κB pathways by Schisandrin B contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cyclooctanes; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Lignans; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; NF-kappa B; Polycyclic Compounds; Receptors, Purinergic P2X7; Signal Transduction | 2016 |
Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis.
Topics: Acetyl-CoA Carboxylase; Animals; Cyclooctanes; Cytokines; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fatty Acid Synthase, Type I; Fatty Liver; Glycerol-3-Phosphate O-Acyltransferase; Heat-Shock Proteins; Hep G2 Cells; Humans; Lignans; Liver; Mice, Inbred C57BL; Palmitic Acid; Polycyclic Compounds; Protective Agents; Transcription Factor CHOP; Triglycerides; Tunicamycin; X-Box Binding Protein 1 | 2016 |
Schisandrin B inhibits the proliferation of airway smooth muscle cells via microRNA-135a suppressing the expression of transient receptor potential channel 1.
Topics: Airway Remodeling; Animals; Apoptosis; Asthma; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclooctanes; Lignans; Male; MicroRNAs; Myocytes, Smooth Muscle; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Up-Regulation | 2016 |
A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Cyclooctanes; Disease Models, Animal; Larva; Lignans; Mutation; Polycyclic Compounds; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Schisandraceae; Vision, Ocular; Zebrafish; Zebrafish Proteins | 2016 |
Schisandrin B inhibits Th1/Th17 differentiation and promotes regulatory T cell expansion in mouse lymphocytes.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclooctanes; Cytokines; Forkhead Transcription Factors; Heme Oxygenase-1; Immunosuppression Therapy; Lignans; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Polycyclic Compounds; Schisandra; T-Box Domain Proteins; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2016 |
Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Concanavalin A; Cyclooctanes; Cytokines; Edema; Enzyme-Linked Immunosorbent Assay; Female; Glutathione; Glutathione Transferase; Inflammation; Lignans; Lipopolysaccharides; Mice; Mice, Inbred ICR; Polycyclic Compounds; RAW 264.7 Cells | 2016 |
Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bile Duct Neoplasms; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Cyclooctanes; Flow Cytometry; Humans; Lignans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Polycyclic Compounds; Xenograft Model Antitumor Assays | 2016 |
Protective effect of Schizandrin B against damage of UVB irradiated skin cells depend on inhibition of inflammatory pathways.
Topics: Cell Survival; Cells, Cultured; Cyclooctanes; Cyclooxygenase 2; Fibroblasts; Humans; Interleukin-18; Interleukin-6; Keratinocytes; Lignans; Malondialdehyde; Matrix Metalloproteinase 1; Oxidative Stress; Plant Extracts; Polycyclic Compounds; Reactive Oxygen Species; Schisandra; Signal Transduction; Skin; Superoxide Dismutase; Ultraviolet Rays | 2017 |
Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Central Amygdaloid Nucleus; Cyclooctanes; Depression; Dose-Response Relationship, Drug; Inflammation; Inflammation Mediators; Lignans; Lipopolysaccharides; Male; Mice; Paraventricular Hypothalamic Nucleus; Plant Extracts; Polycyclic Compounds; Schisandra | 2016 |
Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Cyclooctanes; Cytokines; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Lignans; MAP Kinase Signaling System; Periodontal Ligament; Phosphorylation; Polycyclic Compounds; Tumor Necrosis Factor-alpha | 2017 |
Protective effects of gomisin N against hepatic steatosis through AMPK activation.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Anti-Inflammatory Agents; Cyclooctanes; Cytoplasm; Fatty Acids; Fatty Liver; Hep G2 Cells; Humans; Hydrocarbons, Fluorinated; Lignans; Lipogenesis; Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Phosphorylation; Phytochemicals; Polycyclic Compounds; Protein Kinases; Sterol Regulatory Element Binding Protein 1; Sulfonamides; Triglycerides | 2017 |
Schisandrin B inhibits the proliferation and invasion of glioma cells by regulating the HOTAIR-micoRNA-125a-mTOR pathway.
Topics: Analysis of Variance; Anti-Inflammatory Agents; Cell Count; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Humans; Lignans; MicroRNAs; Neoplasm Invasiveness; Polycyclic Compounds; RNA, Long Noncoding; Signal Transduction; TOR Serine-Threonine Kinases; Transfection | 2017 |
Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-beta; Clone Cells; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 6; Cyclins; Cyclooctanes; Diet, High-Fat; Down-Regulation; Fatty Liver; Histone-Lysine N-Methyltransferase; Lignans; Male; Mice; Mice, Inbred C57BL; Mitosis; Obesity; Polycyclic Compounds; PPAR gamma; Signal Transduction | 2017 |
Biochemical mechanism underlying hypertriglyceridemia and hepatic steatosis/hepatomegaly induced by acute schisandrin B treatment in mice.
Topics: Adipocytes; Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Apolipoprotein B-48; Cell Size; Cholesterol; Cholesterol, VLDL; Cyclooctanes; Fatty Acids, Nonesterified; Fatty Liver; Hepatocyte Growth Factor; Hepatomegaly; Hypertriglyceridemia; Lignans; Liver; Male; Mice; Mice, Inbred ICR; Mitochondria; Polycyclic Compounds; Schisandra; Triglycerides | 2017 |
Schisandrin B displays a protective role against primary pulmonary hypertension by targeting transforming growth factor β1.
Topics: Antineoplastic Agents; Apoptosis; Cell Movement; Cells, Cultured; Cyclooctanes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Hypertension, Pulmonary; Hypoxia; Immunochemistry; Lignans; Medicine, Chinese Traditional; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polycyclic Compounds; Pulmonary Artery; Schisandra; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Vascular Remodeling | 2017 |
Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cyclooctanes; Enzyme Activation; Humans; Lignans; Melanins; Melanocytes; Mice; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Phosphatidylinositol 3-Kinases; Phosphorylation; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Receptor, Melanocortin, Type 1; Signal Transduction; Zebrafish | 2017 |
Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Female; Fruit; Gene Expression; Humans; Hyperprolactinemia; Lignans; Pituitary Gland; Pituitary Neoplasms; Plant Extracts; Polycyclic Compounds; Prolactin; Prolactinoma; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Schisandra | 2017 |
Anti-Inflammatory Effects of Schisandrin B on LPS-Stimulated BV2 Microglia via Activating PPAR-γ.
Topics: Anti-Inflammatory Agents; Cell Line; Cyclooctanes; Enzyme Activation; Humans; Inflammation; Lignans; Lipopolysaccharides; Microglia; Polycyclic Compounds; PPAR gamma | 2017 |
Comparative Phytochemical Analysis of Chinese and Bay Starvine (Schisandra spp.): Potential for Development as a New Dietary Supplement Ingredient.
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dietary Supplements; Dioxoles; Fruit; Lignans; Medicine, Chinese Traditional; Phenols; Phytochemicals; Plant Extracts; Polycyclic Compounds; Schisandra; Spectroscopy, Fourier Transform Infrared; Tannins | 2017 |
Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4.
Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Cyclooctanes; Cytokines; Drug Synergism; Glycyrrhizic Acid; Lignans; Lung; Male; Mice; NADPH Oxidase 4; Polycyclic Compounds; Pulmonary Fibrosis; Signal Transduction; Smad2 Protein | 2017 |
Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Caspase 3; Cyclooctanes; Disease Models, Animal; Lignans; Male; NF-kappa B; Oxidative Stress; Polycyclic Compounds; Rats; Signal Transduction; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2017 |
Schisandrin B inhibits LPS-induced inflammatory response in human umbilical vein endothelial cells by activating Nrf2.
Topics: Anti-Inflammatory Agents; Cyclooctanes; Endothelium, Vascular; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-8; Lignans; Lipopolysaccharides; NF-E2-Related Factor 2; NF-kappa B; Polycyclic Compounds; RNA, Small Interfering; Schisandra; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2017 |
Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach.
Topics: Actinin; Animals; Bosentan; Cardiotonic Agents; Cell Differentiation; Cell Line; Cyclooctanes; Drugs, Chinese Herbal; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Intestinal Mucosa; Intestines; Lignans; Male; Medicine, Chinese Traditional; Metabolic Networks and Pathways; Metabolome; Myocytes, Cardiac; Natriuretic Peptide, Brain; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Sulfonamides; Troponin T | 2017 |
A sensitive UHPLC-MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study.
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Polycyclic Compounds; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells.
Topics: alpha-MSH; Animals; Cyclooctanes; Lignans; Magnetic Resonance Spectroscopy; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Phosphorylation; Plant Extracts; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Schisandra | 2017 |
Schisandrin B Ameliorates Myocardial Ischemia/Reperfusion Injury Through Attenuation of Endoplasmic Reticulum Stress-Induced Apoptosis.
Topics: Activating Transcription Factor 6; Animals; Apoptosis; Cyclooctanes; eIF-2 Kinase; Endoplasmic Reticulum Stress; Lignans; Male; Myocardial Reperfusion Injury; Oxidative Stress; Polycyclic Compounds; Rats | 2017 |
Schisandrin B attenuates CCl
Topics: Animals; Carbon Tetrachloride; Cyclooctanes; Lignans; Liver Cirrhosis; Male; Molecular Structure; NF-E2-Related Factor 2; Polycyclic Compounds; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2017 |
Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclooctanes; Doxorubicin; Drug Resistance; Humans; Lignans; Polycyclic Compounds; Proteasome Endopeptidase Complex; Survivin | 2017 |
Investigation of pharmacokinetics, tissue distribution and excretion of schisandrin B in rats by HPLC-MS/MS.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Female; Lignans; Linear Models; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tissue Distribution | 2018 |
Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents; Apoptosis; Autophagy; Cell Line; Cyclooctanes; Cyclosporine; Cytoprotection; Epithelial Cells; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Humans; Kidney; Lignans; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Polycyclic Compounds; Reactive Oxygen Species; Schisandra | 2017 |
Schisandrin B regulates lipid metabolism in subcutaneous adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Body Weight; Cyclooctanes; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation; Glycolysis; Lignans; Lipase; Lipid Metabolism; Lipolysis; Mice; Molecular Structure; Obesity; Oxidation-Reduction; Polycyclic Compounds; Subcutaneous Fat | 2017 |
Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation.
Topics: Acne Vulgaris; Anti-Inflammatory Agents; Cyclooctanes; Humans; Inflammation; Lignans; MAP Kinase Signaling System; Polycyclic Compounds; Propionibacterium acnes; THP-1 Cells | 2017 |
Schisandrin B down-regulated lncRNA BCYRN1 expression of airway smooth muscle cells by improving miR-150 expression to inhibit the proliferation and migration of ASMC in asthmatic rats.
Topics: Animals; Asthma; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooctanes; Disease Models, Animal; Down-Regulation; Female; Lignans; MicroRNAs; Myocytes, Smooth Muscle; Polycyclic Compounds; Rats, Sprague-Dawley; RNA, Long Noncoding | 2017 |
Comparative effects of schisandrin A, B, and C on Propionibacterium acnes-induced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis.
Topics: Cell Survival; Cyclooctanes; Humans; Interleukin-1beta; Lignans; NLR Family, Pyrin Domain-Containing 3 Protein; Polycyclic Compounds; Propionibacterium acnes; Pyroptosis; Schisandra; THP-1 Cells | 2017 |
Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles.
Topics: Animals; Biological Availability; Cardiotonic Agents; Cell Death; Cyclooctanes; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Humans; Lignans; Lipids; Matrix Metalloproteinases; Myocardial Infarction; Nanoparticles; Particle Size; Peptides; Polycyclic Compounds; Polyethylene Glycols; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Tissue Distribution | 2017 |
Protective effects of Schisandrin B on cigarette smoke-induced airway injury in mice through Nrf2 pathway.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Cigarette Smoking; Cyclooctanes; Cytokines; Lignans; Lung; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Pneumonia; Polycyclic Compounds; Schisandra; Signal Transduction | 2017 |
Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cyclooctanes; Diabetes Mellitus; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hypoglycemic Agents; Insulin; Insulin Resistance; Lignans; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle, Skeletal; Organelle Biogenesis; Polycyclic Compounds | 2017 |
Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats.
Topics: Animals; Apoptosis; Biomarkers; Creatine Kinase, MB Form; Cyclooctanes; Disease Models, Animal; Lignans; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Troponin T | 2018 |
Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cisplatin; Cyclooctanes; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Humans; Inhibitor of Apoptosis Proteins; Kidney Tubules; Lignans; NF-kappa B; Polycyclic Compounds; Protective Agents; Schisandraceae; Signal Transduction; Survivin; Up-Regulation | 2018 |
Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3.
Topics: Atorvastatin; Cyclooctanes; Drug Interactions; HEK293 Cells; Humans; Kinetics; Lignans; Liver; Liver-Specific Organic Anion Transporter 1; Polycyclic Compounds; Protective Agents; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2019 |
Reduction of Aβ Generation by Schisandrin B through Restraining Beta-Secretase 1 Transcription and Translation.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Cell Line; Cyclooctanes; Humans; Lignans; Polycyclic Compounds; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic | 2018 |
Sedative and hypnotic effects of Schisandrin B through increasing GABA/Glu ratio and upregulating the expression of GABA
Topics: Animals; Brain; Cyclooctanes; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Hypnotics and Sedatives; Lignans; Locomotion; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Up-Regulation | 2018 |
Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Behavior, Animal; Cyclooctanes; Disease Models, Animal; Glutathione; Kelch-Like ECH-Associated Protein 1; Lignans; Male; Malondialdehyde; Mice, Inbred C57BL; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Polycyclic Compounds; Reactive Oxygen Species; Signal Transduction; Stress, Psychological; Superoxide Dismutase | 2019 |
Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooctanes; Dose-Response Relationship, Drug; Inflammation; Lignans; MAP Kinase Signaling System; Matrix Metalloproteinases; NF-kappa B; Osteoarthritis; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Structure-Activity Relationship | 2018 |
[Rapid identification of the different constituents in Fructus Schisandrae Chinensis before and after processing by UHPLC-QTOF/MS~E combining with metabonomics].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Metabolomics; Polycyclic Compounds; Schisandra | 2016 |
[Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS].
Topics: Acetic Acid; Animals; Bile; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Feces; Lignans; Liver Diseases, Alcoholic; Plasma; Polycyclic Compounds; Rats; Schisandra; Urine | 2016 |
Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer's Disease: Stereochemistry and Biological Activity.
Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Cell Line, Tumor; Cell Survival; Cyclooctanes; Enzyme Inhibitors; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Lignans; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Neuroprotective Agents; Polycyclic Compounds; Stereoisomerism; Treatment Outcome | 2019 |
[Protection effects of schizandrin B against liver injury induced by clozapine in mice].
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clozapine; Cyclooctanes; Glutathione; Heme Oxygenase-1; Lignans; Liver; Malondialdehyde; Membrane Proteins; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Polycyclic Compounds; Protective Agents; Signal Transduction; Superoxide Dismutase | 2017 |
Simultaneous quantification of Schisandrin B enantiomers in rat plasma by chiral LC-MS/MS: Application in a stereoselective pharmacokinetic study.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, Liquid; Cyclooctanes; Dioxoles; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tandem Mass Spectrometry | 2018 |
Schisandrin B exhibits potent anticancer activity in triple negative breast cancer by inhibiting STAT3.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cyclooctanes; Dose-Response Relationship, Drug; Female; Humans; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; Polycyclic Compounds; STAT3 Transcription Factor; Triple Negative Breast Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Cyclooctanes; Ethanol; Fatty Liver, Alcoholic; Hep G2 Cells; Humans; Lignans; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Polycyclic Compounds | 2018 |
Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway.
Topics: Antioxidants; Cell Death; Cell Line; Cyclooctanes; Humans; Keratinocytes; Lignans; Mitochondria; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Polycyclic Compounds; Protective Agents; Reactive Oxygen Species; Signal Transduction; tert-Butylhydroperoxide | 2018 |
Inhibitory effects of Schisandrin B on human prostate cancer cells.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Humans; Janus Kinase 2; Lignans; Male; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Polycyclic Compounds; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen; S Phase; Signal Transduction; STAT3 Transcription Factor | 2019 |
Schisandrin B attenuates epidural fibrosis in postlaminectomy rats by inhibiting proliferation and extracellular matrix production of fibroblasts.
Topics: Animals; Cell Proliferation; Cyclooctanes; Extracellular Matrix; Fibroblasts; Fibrosis; Laminectomy; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2019 |
Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress.
Topics: Animals; Cyclooctanes; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Lignans; Mice; Mice, Inbred C57BL; Molecular Conformation; Oxidative Stress; Polycyclic Compounds; Reactive Oxygen Species; Streptozocin | 2019 |
Evaluation of the inhibition of human carboxylesterases (CESs) by the active ingredients from
Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; Lignans; Microsomes, Liver; Molecular Docking Simulation; Polycyclic Compounds; Schisandra | 2019 |
Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4.
Topics: Animals; Anti-Inflammatory Agents; Cyclooctanes; Down-Regulation; Inflammation; Interleukin-1beta; Lignans; Lipopolysaccharides; Macrophages; Mice; MicroRNAs; Polycyclic Compounds; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Cyclooctanes; Disease Models, Animal; Glomerulonephritis, IGA; Kidney; Kidney Function Tests; Lignans; NF-kappa B; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Signal Transduction; Spleen | 2019 |
Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway.
Topics: Angiotensin II; Animals; Cells, Cultured; Cyclooctanes; Endothelial Cells; Kelch-Like ECH-Associated Protein 1; Lignans; Male; NF-E2-Related Factor 2; Oxidative Stress; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2018 |
Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver.
Topics: Activation, Metabolic; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Lignans; Liver; Male; Methane; Mice; Microsomes, Liver; NF-E2-Related Factor 2; Polycyclic Compounds; Signal Transduction | 2018 |
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells.
Topics: B7-2 Antigen; Chlamydophila pneumoniae; Coculture Techniques; Cyclooctanes; Dendritic Cells; Gene Expression; Glutathione; HLA-DR Antigens; Humans; Immunologic Factors; Interleukin-10; Interleukin-12; Interleukin-6; Lignans; Lipopolysaccharides; Lymphocyte Activation; Oxidation-Reduction; Polycyclic Compounds; Primary Cell Culture; Reactive Oxygen Species; Schisandra; T-Lymphocytes; THP-1 Cells | 2019 |
Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling.
Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Central Nervous System Agents; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Zebrafish | 2018 |
Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation.
Topics: Animals; Cyclooctanes; Cytochrome P-450 CYP3A; Drug Interactions; Drugs, Chinese Herbal; Humans; Lignans; Male; Nifedipine; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2019 |
Schisandrin B ameliorates high-glucose-induced vascular endothelial cells injury by regulating the Noxa/Hsp27/NF-κB signaling pathway.
Topics: Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Cyclooctanes; Endothelial Cells; Glucose; HSP27 Heat-Shock Proteins; Humans; Inflammation; Lignans; NF-kappa B; Polycyclic Compounds; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2019 |
Schisandrin B prevents ulcerative colitis and colitis-associated-cancer by activating focal adhesion kinase and influence on gut microbiota in an in vivo and in vitro model.
Topics: Animals; Caco-2 Cells; Colitis, Ulcerative; Colonic Neoplasms; Cyclooctanes; Cytoprotection; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Gastrointestinal Microbiome; HCT116 Cells; Humans; Intestinal Mucosa; Lignans; Male; Mice; Mice, Inbred C57BL; Permeability; Polycyclic Compounds; Signal Transduction | 2019 |
An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lignans; Medicine, Chinese Traditional; Plants, Medicinal; Polycyclic Compounds; Quality Control; Rats; Schisandra; Tandem Mass Spectrometry | 2019 |
Schizandrin B attenuates angiotensin II induced endothelial to mesenchymal transition in vascular endothelium by suppressing NF-κB activation.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclooctanes; Cytokines; Disease Models, Animal; Endothelium, Vascular; Fibrosis; Gene Expression Regulation; Inflammation; Lignans; Male; Mice; Mice, Inbred C57BL; NF-kappa B p50 Subunit; Oxidative Stress; Phenotype; Polycyclic Compounds; Signal Transduction; Vascular Remodeling | 2019 |
Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cyclooctanes; Down-Regulation; Endoplasmic Reticulum Stress; Gene Expression Profiling; Lignans; Liver; Liver Cirrhosis; Male; Medicine, Chinese Traditional; Polycyclic Compounds; Rats; Rats, Wistar; RNA; Schisandra; Sequence Analysis, RNA; Signal Transduction; Transcriptome; Up-Regulation | 2019 |
The synergistic anti-tumor effect of schisandrin B and apatinib.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Lignans; Molecular Structure; Polycyclic Compounds; Pyridines | 2020 |
Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury, Chronic; Cyclooctanes; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Hepatocytes; Humans; Lignans; Polycyclic Compounds; Protective Agents; Schisandra | 2020 |
Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT.
Topics: Actins; Cells, Cultured; Cyclooctanes; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Kidney; Lignans; MicroRNAs; Polycyclic Compounds; Snail Family Transcription Factors; Transforming Growth Factor beta1; Ureteral Obstruction; Zinc Finger E-box Binding Homeobox 2 | 2019 |
Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway.
Topics: Animals; Carbon Tetrachloride Poisoning; Cyclooctanes; Humans; Lignans; Liver Cirrhosis; Male; MicroRNAs; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta | 2020 |
Schisandrin A and B enhance the dentate gyrus neurogenesis in mouse hippocampus.
Topics: Animals; Cell Proliferation; Cyclooctanes; Dentate Gyrus; Hippocampus; Lignans; Male; Mice; Neurogenesis; Neurons; Polycyclic Compounds | 2020 |
Enhanced antitumor efficacy using epirubicin and schisandrin B co-delivery liposomes modified with PFV via inhibiting tumor metastasis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chick Embryo; Chorioallantoic Membrane; Cyclooctanes; Epirubicin; Female; Humans; Lignans; Liposomes; Lung Neoplasms; Mice; Neoplasm Invasiveness; Polycyclic Compounds; Xenograft Model Antitumor Assays | 2020 |
Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyclooctanes; Doxorubicin; Epithelial-Mesenchymal Transition; Humans; Lignans; Liposomes; Lung Neoplasms; Polycyclic Compounds; Vascular Endothelial Growth Factor A | 2021 |
Gomisin N from
Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Adipocytes; Adipogenesis; Adipose Tissue, Brown; AMP-Activated Protein Kinases; Animals; Biomarkers; Bone Morphogenetic Protein 4; Cyclooctanes; Enzyme Activation; Fatty Acids; Lignans; Lipid Metabolism; Mice; Oxidation-Reduction; Phenotype; Polycyclic Compounds; Schisandra; Thermogenesis; Uncoupling Protein 1 | 2020 |
Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS.
Topics: Benzopyrans; Butyrates; Chromatography, Liquid; Coumarins; Cyclooctanes; Dioxoles; Flavanones; Food Analysis; Fruit; Glucosides; Glycosides; Glycyrrhizic Acid; Herbal Medicine; Iridoids; Isoflavones; Lignans; Plant Roots; Plants, Medicinal; Polycyclic Compounds; Tandem Mass Spectrometry | 2020 |
Albendazole-Schisandrin B Co-Therapy on
Topics: Albendazole; Angiostrongylus cantonensis; Animals; Apoptosis; Cyclooctanes; Disease Models, Animal; Drug Synergism; Gene Expression Regulation; Inflammasomes; Lignans; Meningoencephalitis; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Pyroptosis; Strongylida Infections; Survival Analysis; Th1 Cells; Th2 Cells | 2020 |
Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooctanes; Lignans; Male; NF-kappa B; Polycyclic Compounds; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2020 |
Gomisin N Exerts Anti-liver Cancer Effects and Regulates PI3K-Akt and mTOR-ULK1 Pathways in Vitro.
Topics: Antineoplastic Agents; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Cyclooctanes; Humans; Intracellular Signaling Peptides and Proteins; Lignans; Liver Neoplasms; Phosphatidylinositol 3-Kinase; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Schisandrin B regulates MC3T3-E1 subclone 14 cells proliferation and differentiation through BMP2-SMADs-RUNX2-SP7 signaling axis.
Topics: 3T3 Cells; Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Proliferation; Core Binding Factor Alpha 1 Subunit; Cyclooctanes; Heart; Inflammation; Lignans; Liver; Mice; Osteoblasts; Polycyclic Compounds; Schisandra; Signal Transduction; Smad Proteins; Sp7 Transcription Factor | 2020 |
Functional Characterization of Gomisin N in High-Fat-Induced
Topics: Animals; Body Weight; Coconut Oil; Cyclooctanes; Diet, High-Fat; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Energy Metabolism; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Humans; Lignans; Liver; Membrane Proteins; Obesity; Polycyclic Compounds; Schisandra | 2020 |
High-throughput metabolomics discovers metabolite biomarkers and insights the protective mechanism of schisandrin B on myocardial injury rats.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclooctanes; Disease Models, Animal; Lignans; Male; Metabolomics; Myocardium; Polycyclic Compounds; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2021 |
Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of gastric cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclooctanes; Lignans; Liposomes; Mice; Mice, Nude; Polycyclic Compounds; Stomach Neoplasms; Vinorelbine | 2021 |
[Preparation and evaluation of schisandrin B-loaded F127 modified lipid-polymer nanoparticles for inhibition of breast cancer lung metastasis].
Topics: Animals; Cyclooctanes; Lignans; Lipids; Lung Neoplasms; Mice; Nanoparticles; Polycyclic Compounds; Polyethylenes; Polymers; Polypropylenes; Rats; Swine | 2020 |
Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4/ROS Pathway.
Topics: Animals; Apoptosis; Autophagy; Cardiomyopathy, Alcoholic; Cyclooctanes; Down-Regulation; Ethanol; Gene Knockdown Techniques; Heart Injuries; Lignans; Male; Mice, Inbred C57BL; Myocytes, Cardiac; NADPH Oxidase 4; Polycyclic Compounds; Primary Cell Culture; Protective Agents; Reactive Oxygen Species; Signal Transduction | 2021 |
Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Cells, Cultured; Cyclooctanes; Female; Humans; Inflammatory Bowel Diseases; Lignans; Mice, Inbred C57BL; Polycyclic Compounds; Th17 Cells | 2021 |
Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats.
Topics: Animals; Biomarkers; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Glucuronosyltransferase; Glutathione Transferase; Herb-Drug Interactions; Intestines; Lignans; Liver; Male; Microsomes; NAD(P)H Dehydrogenase (Quinone); Nifedipine; Oxidation-Reduction; Polycyclic Compounds; Rats, Sprague-Dawley; Saponins; Spirostans | 2021 |
Schisandrin B inhibits α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways.
Topics: alpha-MSH; Animals; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; Cyclooctanes; Down-Regulation; Lignans; MAP Kinase Signaling System; Melanins; Melanoma, Experimental; Mice; Polycyclic Compounds; Signal Transduction | 2021 |
Schisandrin B for the treatment of male infertility.
Topics: Animals; Cyclooctanes; Drugs, Chinese Herbal; Gene Expression; Infertility, Male; Lignans; Male; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Spermatogenesis; Testis | 2021 |
Biomineralized separation, concentration, and evaluation of the effectiveness of Schisandra chinensis fruit extract.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Cyclooctanes; Fruit; Lignans; Mice; Plant Extracts; Polycyclic Compounds; Schisandra | 2021 |
Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis.
Topics: Airway Remodeling; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Cells, Cultured; Cyclooctanes; Disease Models, Animal; Female; Inflammasomes; Lignans; Lung; Macrophages, Alveolar; MicroRNAs; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pneumonia; Polycyclic Compounds; Pyroptosis; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; TRPC Cation Channels | 2021 |
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cyclooctanes; Inflammasomes; Lignans; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Polycyclic Compounds; RAW 264.7 Cells; Schistosoma mansoni; Schistosomiasis mansoni; Spleen | 2021 |
Schisandrin B Attenuates Airway Inflammation by Regulating the NF-
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclooctanes; Disease Models, Animal; Humans; Lignans; Lung; Male; Mice; NF-E2-Related Factor 2; NF-kappa B; Ovalbumin; Oxidative Stress; Polycyclic Compounds; Signal Transduction; Specific Pathogen-Free Organisms | 2021 |
Protective effects of Schisandrin B against D-GalN-induced cell apoptosis in human hepatocyte (L02) cells via modulating Bcl-2 and Bax.
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line; Cyclooctanes; Galactosamine; Hepatocytes; Humans; Lignans; Polycyclic Compounds; Protective Agents; Proto-Oncogene Proteins c-bcl-2 | 2021 |
The anti-ovarian cancer effect of RPV modified paclitaxel plus schisandra B liposomes in SK-OV-3 cells and tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell-Penetrating Peptides; Cyclooctanes; Female; Humans; Lignans; Liposomes; Mice; Mice, Inbred BALB C; Ovarian Neoplasms; Paclitaxel; Polycyclic Compounds; Xenograft Model Antitumor Assays | 2021 |
Schisandrin B promotes T
Topics: Animals; B-Lymphocytes; Cell Differentiation; Cyclooctanes; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Immunoblotting; Interferon-gamma; Interleukin-4; Lignans; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Real-Time Polymerase Chain Reaction; STAT1 Transcription Factor; Th1 Cells | 2021 |
Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Colitis; Cyclooctanes; Epithelial Cells; HCT116 Cells; Humans; Inflammasomes; Lignans; Mice; Mice, Inbred C57BL; Mitochondria; Network Pharmacology; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Polycyclic Compounds; Pyroptosis | 2021 |
Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colitis-Associated Neoplasms; Cyclooctanes; Disease Models, Animal; Humans; Lignans; Male; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Sirtuin 1; Ubiquitin-Protein Ligases | 2021 |
Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis.
Topics: Animals; Antifibrotic Agents; Apoptosis; Cell Line; Cyclooctanes; Hepatic Stellate Cells; Humans; Lignans; Liver Cirrhosis; Polycyclic Compounds; Protective Agents; Rats | 2021 |
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Topics: Animals; Anthelmintics; Cyclooctanes; Lignans; Mice; Polycyclic Compounds; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni | 2022 |
Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Body Weight; Cyclooctanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; Lignans; Lipid Metabolism; Lipids; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Polycyclic Compounds; RNA, Messenger; Sterol Regulatory Element Binding Protein 1 | 2022 |
Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Brain Injuries; Caspase 3; Cyclooctanes; Evans Blue; Inflammasomes; Interleukin-18; Lignans; NLR Family, Pyrin Domain-Containing 3 Protein; Polycyclic Compounds; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Water | 2022 |
Schisandrin B suppresses osteosarcoma lung metastasis
Topics: Animals; Antineoplastic Agents; Apoptosis; beta Catenin; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooctanes; Disease Models, Animal; Humans; Lignans; Lung Neoplasms; Mice; Osteosarcoma; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Wnt Signaling Pathway | 2022 |
Schisandrin B promotes Foxp3
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Asthma; Cyclooctanes; Dendritic Cells; Disease Models, Animal; Forkhead Transcription Factors; Heme Oxygenase-1; Hypersensitivity; Immunoglobulin E; Immunomodulating Agents; Lignans; Mice; Mice, Inbred BALB C; Polycyclic Compounds; Respiratory Hypersensitivity; T-Lymphocytes, Regulatory; Th2 Cells | 2022 |
Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5-FU in vitro and in vivo.
Topics: Apoptosis; Cell Line, Tumor; Cyclooctanes; Fluorouracil; Humans; Lignans; Polycyclic Compounds; Stomach Neoplasms | 2022 |
Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cyclooctanes; Diet, High-Fat; Fatty Acids, Nonesterified; Hepatocytes; Ketone Bodies; Lignans; Lipid Metabolism; Liver; Mice; Non-alcoholic Fatty Liver Disease; Polycyclic Compounds; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
Schisandrin B Induced ROS-Mediated Autophagy and Th1/Th2 Imbalance
Topics: Animals; Autophagy; Cyclooctanes; Cytokines; Lignans; Mice; Polycyclic Compounds; Reactive Oxygen Species; RNA, Messenger; Selenoproteins; Th1 Cells; Th2 Cells | 2022 |
Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte.
Topics: Acetaminophen; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Cyclooctanes; Hepatocytes; Humans; Lignans; Mitogen-Activated Protein Kinase Kinases; Polycyclic Compounds | 2022 |
Fruit of Schisandra chinensis and its bioactive component schizandrin B ameliorate obesity-induced skeletal muscle atrophy.
Topics: Animals; Cyclooctanes; Fruit; Lignans; Mice; Muscle, Skeletal; Muscular Atrophy; Obesity; Polycyclic Compounds; Schisandra | 2022 |
A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties.
Topics: Animals; Biomarkers; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds; Rats; Schisandra | 2022 |
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclooctanes; Diet; Doxorubicin; Ferroptosis; Lignans; Lipid Peroxidation; Oxidative Stress; Polycyclic Compounds; Rats | 2022 |
Schisandrin B protects against LPS-induced inflammatory lung injury by targeting MyD88.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Lignans; Lipopolysaccharides; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Toll-Like Receptor 4 | 2023 |
Schisandrin B Improves the Hypothermic Preservation of Celsior Solution in Human Umbilical Cord Mesenchymal Stem Cells.
Topics: Humans; Lignans; Mesenchymal Stem Cells; Umbilical Cord | 2023 |
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
Topics: Animals; Brain Injuries; Ethanol; Lignans; Liver; Mice | 2023 |
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Topics: Carcinoma, Hepatocellular; Caspase 3; Hep G2 Cells; Humans; Killer Cells, Natural; Lignans; Liver Neoplasms; Pyroptosis | 2023 |