Page last updated: 2024-08-22

schizandrin and lignans

schizandrin has been researched along with lignans in 181 studies

Research

Studies (181)

TimeframeStudies, this research(%)All Research%
pre-199017 (9.39)18.7374
1990's16 (8.84)18.2507
2000's35 (19.34)29.6817
2010's84 (46.41)24.3611
2020's29 (16.02)2.80

Authors

AuthorsStudies
Ikeya, Y; Kobayashi, H; Taguchi, H; Yosioka, I1
He, J; Liu, Y; Sha, D; Wang, L; Zheng, S1
Cui, YY; Wang, MZ1
Li, XY1
Niu, X; Zhang, L1
Lin, TJ1
Jia, WY; Li, XJ; Liu, GT; Xin, WJ; Zhao, BL1
Li, XJ; Liu, GT; Xin, WJ; Zhao, BL1
Song, WZ; Tong, YY; Wang, K1
Liu, GT2
Rao, WW1
Liu, GT; Wei, HL1
Long, ZZ; Xie, SS1
Li, M1
Long, ZZ1
Bian, ZJ; Niu, XY; Ren, ZH1
Bian, ZJ; Niu, XY; Ren, ZH; Wang, WJ1
Cresteil, T; Le Provost, E; Lesca, P; Liu, KT1
Lesca, P; Liu, KT2
Aburada, M; Harada, M; Ikeya, Y; Maeda, S; Miyamoto, Y; Shinbo, M; Sudo, K; Taguchi, H; Takeda, S1
Gu, KJ; Tang, CF; Xi, GL; Zhang, HL1
Aburada, M; Harada, M; Ikeya, Y; Maeda, S; Sudo, K; Taguchi, H; Yoshioka, I1
Ikeya, Y; Maruno, M; Ono, H; Oyama, T; Sugama, K; Takeda, S; Tanaka, M; Wakamatsu, T1
Amagaya, S; Ikeya, Y; Maruno, M; Matsuzaki, Y; Ono, H; Takeda, S; Wakui, Y1
Ahn, KS; Jung, KY; Lee, HK; Lee, IS; Oh, SR; Park, SH1
Che, CT; Ip, SP; Ko, KM1
Chin, YW; Choi, YH; Jang, YP; Joung, SN; Kim, J; Kim, JY; Kim, Y; Kim, YC; Noh, MJ; Yoo, KP1
Li, RC; Lin, KF; Yeung, RY; Zhu, M1
Choi, SJ; Jeong, CK; Kim, SB; Ko, GI; Lee, HS; Sohn, DH1
Coleman, RS; Guernon, JM; Roland, JT1
Guo, J; Lu, Q; Sun, X; Wei, X; Yao, Z; Zhang, D; Zhang, X; Zhang, Z1
Hsieh, MT; Lin, LW; Wang, WH; Wu, CR1
Havlícková, P; Krenková, M; Opletal, L2
Chang, J; Xie, J1
Gu, ZB; Han, GX; Wang, LX; Zhang, WD1
George, KM; Molander, GA; Monovich, LG1
Kim, SH; Kim, SR; Kim, YC; Koo, KA; Lee, MK; Lee, NG; Markelonis, GJ; Oh, TH; Sung, SH; Yang, JH1
Pan, WJ; Xiao, X; Xiao, XH; Yuan, HL; Zhao, YL1
Li, JQ; Li, P; Mu, J; Zhang, LQ; Zhu, XL1
Fan, G; Peng, J; Qu, L; Wu, Y; Zhou, X1
Li, H; Li, X; Wang, G; Wang, R; Wang, W; Xie, H; Xu, M; Yue, L; Zhu, D1
Gao, Q; Li, XG; Luo, HM; Weng, W1
Yan, YQ; Yu, BY; Yue, L; Zhu, DN1
Konishi, T; Kushida, M; Nakajima, Y; Nishida, H; Ogawa, Y; Sato, S; Tatewaki, N1
Bae, EA; Bae, KH; Kim, DH; Lee, B; Phuong, TT; Shin, YW; Trinh, HT1
Egashira, N; Fujiwara, M; Iwasaki, K; Kurauchi, K; Mishima, K; Oishi, R; Orito, K1
Huang, Q; Jia, YW; Wang, GJ; Xie, HT; Xu, MJ1
Fujii, M; Hou, DX; Lin, S1
Huang, Q; Jia, Y; Wang, G; Wang, W; Xie, H; Xu, M1
Huang, M; Jin, J; Liu, GT; Sun, H1
Chen, M; Dong, L; Huang, C; Li, L; Liao, Z; Xu, X1
Cheng, HY; Hsieh, CC; Hsieh, MT; Li, WC; Lin, YT; Lu, TC; Peng, WH; Tsai, FH; Wu, CR1
Chen, M; Liao, Z; Ma, W; Sun, M; Wen, Y; Xu, X; Zhang, H1
Bae, KH; Guo, LY; Hong, YN; Hung, TM; Kang, SS; Kim, HP; Kim, YS; Shin, EM; Zhou, HY1
Billinsky, JL; Krol, ES1
Caichompoo, W; Gao, HJ; Hou, TT; Qin, LP; Zhang, QY; Zhou, XJ1
Huang, X; Liu, SY; Liu, ZQ; Song, FR1
Gao, XM; He, F; Huang, SX; Lu, Y; Pu, JX; Sun, HD; Wang, RR; Xiao, WL; Zheng, QT; Zheng, YT; Zhong, JL1
Gu, P; Hu, LP; Li, J; Lu, B; Shao, JQ; Sun, LJ; Wang, GH; Wang, J; Wang, Q; Wang, YT; Wu, B1
Bae, H; Hong, M; Jung, SK; Kim, J; Kim, Y; Lee, H; Oh, BG; Shin, M1
Bae, K; Chung, JW; Guo, LY; Hung, TM; Jang, S; Kang, SS; Kim, HP; Kim, YS; Shin, EM1
Bae, K; Kang, SS; Kim, SJ; Kim, YS; Lee, EJ; Lee, SK; Min, HY1
Chen, J; Xiang, Q; Yang, X1
Ji, H; Liu, H; Liu, Y; Shao, B; Tang, J; Wu, L; Zhu, D2
Cao, YF; Fang, ZZ; Ge, GB; Hu, D; Huang, T; Huo, H; Li, J; Liu, HX; Sun, DX; Wang, YC; Yang, L; Yin, J; Zhang, YY1
Huang, X; Huang, YJ; Li, YB; Wang, Q; Xiao, XH; Yuan, HL1
Chen, W; Gao, S; Sun, L; Tai, Z; Wei, H; Xu, W1
Bauer, R; Blunder, M; Fabian, WM; Hüfner, A; Kunert, O; Pferschy-Wenzig, EM; Saf, R; Schühly, W1
Hu, Y; Sun, R; Yu, J; Zhou, J1
Ha, H; Lee, H; Lee, JA; Lee, KY; Lee, MY; Lee, NH; Seo, CS; Shin, HK1
Lin, X; Shaw, PC; Song, JX; Sze, SC; Tong, Y; Wong, RN; Zhang, YB1
EFIMOV, VV; VLASOVA, LN1
Chen, CH; Chen, Y; Chen, YC; Jeng, CJ; Wang, SM; Yang, SH1
Li, SM; Li, X; Meng, FY; Ruan, HL; Sun, JX; Yu, HY1
Liu, TT; Ma, CH; Wang, SY; Yang, L; Zhang, RR; Zu, YG1
Che, CT; Ip, PS; Yang, J; Yeung, JH1
Guan, M; Li, T; Liu, Y; Sheng, Y; Wang, Y; Yuan, G1
Choi, YW; Kim, SG; Kim, Y; Kim, YH; Lee, SJ; Park, DJ; Park, SY; Shon, KJ1
Che, CT; Ip, PS; Yang, JM; Yeung, JH1
Liu, TT; Ma, CH; Yang, FJ; Yang, L; Zhang, L; Zhang, ZH; Zhao, CJ; Zu, YG1
Jeong, SI; Kim, SJ; Kim, SY; Kwon, TH; Yu, KY1
An, Y; Chang, Y; Chen, X; Fan, H; Huang, X; Lei, J; Liu, S; Liu, W; Ren, K; Shen, N; Wang, Y; Xu, N1
Fan, XH; Guo, WJ; Shao, Q; Zhang, YF1
Guan, J; Sun, DY; Zhang, XR; Zhao, Y; Zhu, HY1
Chen, PD; Wu, Y; Yin, FZ1
Cao, Y; Han, N; He, R; Hu, D; Liu, Z; Miao, L; Yin, J1
Jeong, HJ; Kim, HM; Moon, PD1
Gao, Q; Liao, MJ; Luo, HM; Xu, X; Zhang, Z; Zhou, X; Zhou, XW1
Ko, KM; Pan, SY; Sun, N; Wang, XY; Yu, Q; Yu, ZL; Zhang, Y1
Dong, JP; He, FC; Li, SX; Liu, WZ; Su, RQ; Zhao, ZQ1
Chao, J; Cheng, HY; Hsieh, MT; Lee, MS; Lin, LW; Peng, WH; Tsai, FS; Yen, JC1
Han, Y; Sun, H; Wang, X; Wei, W; Wu, F; Zhang, A1
Bi, K; Chen, X; Fan, R; Geng, L; He, B; Jia, Y; Li, Q; Su, D; Wei, B; Zhao, L1
Chen, D; Chen, M; Lee, KH; Liao, Z; Morris-Natschke, SL; Xu, B; Xu, X; Yang, P1
Chen, H; Huang, ZJ; Lu, TL; Mao, CQ; Song, Y; Sun, Y; Wu, XY; Xu, B; Zhou, Y1
Han, Y; Lu, SW; Sun, H; Wang, XJ; Wu, XH; Yan, GL; Zhang, AH1
Chen, H; Hu, JP; Li, Y; Sheng, L; Wang, BL1
Antoine, MH; Bunel, V; Duez, P; Nortier, J; Stévigny, C1
Afanaseva, SV; Baulin, SI; Rogacheva, SM1
Cheng, Y; Fan, X; Guo, W; Li, Z; Shao, Q; Zhan, S1
Dai, G; Ji, D; Li, L; Lu, T; Mao, C; Sun, Y; Wu, X; Xu, B; Yin, F; Zhou, Y1
An, Y; Shi, G; Sun, X; Wu, Q; Wu, X; Zhang, M; Zhang, P1
Hu, XL; Liu, ZQ; Pi, ZF; Song, FR; Yu, XL1
Cao, G; Cao, Z; Guo, Z; Kou, J; Li, L; Yang, H; Yu, B; Zhou, H1
Kou, JP; Li, SX; Lv, YN; Yu, BY; Zhai, KF1
Chu, ZY; Tian, L; Wu, LH1
Jiang, M; Kang, L; Li, Z; Liu, X; Wang, Y; Xu, L; Zhao, X1
Cho, SJ; Choi, MS; Jung, UJ; Kim, HJ; Moon, BS; Park, HJ1
Bi, K; Jia, Y; Li, X; Liu, A; Liu, Z; Mao, X; Zhang, C; Zhao, X1
Fan, XH; Kang, LY; Li, Z; Zhong, Y; Zhu, JQ1
Cao, ZP; Huang, JN; Jiang, ZJ; Li, CH; Wang, CY; Xiao, P; Xie, X; Yang, JF1
Park, JH; Yoon, J1
An, LP; Chen, M; Dou, ZH; Ju, YF; Luo, L; Miao, YX; Qiao, J1
Chen, BP; Huang, GR; Huang, XF; Huang, YQ; Huang, ZS; Mo, XQ; Su, JW; Tang, HY; Wei, HY; Wei, LD; Wu, MH; Yu, WQ; Zhao, LJ; Zhou, XH1
Cai, Q; Du, SS; Zheng, LS1
Lin, HC; Wang, GL; Zhang, LX; Zhu, HY1
Ekiert, H; Kisiel, W; Szewczyk, A; Szopa, A1
An, LB; Cui, L; Dong, PP; Fang, ZZ; Gonzalez, FJ; Li, WT; Song, JH; Sun, XY; Wang, LX; Wu, X; Zhang, YY; Zhao, DW1
Chen, HL; Kou, JP; Li, DP; Li, F; Tan, YS; Yan, Y; Yu, BY; Zhai, KF1
Chen, HL; Kou, JP; Li, F; Lv, YN; Shen, K; Tan, YS; Yu, BY; Zhai, KF1
Cai, ZP; Huo, DS; Shao, G; Wang, H; Yang, ZJ; Zhang, M; Zhao, ZY1
Fan, X; Kou, J; Li, F; Ma, X; Pang, L; Song, M; Yu, B; Zhang, Y1
Han, NR; Jeong, HJ; Kim, HM; Kim, HY; Kim, NR; Moon, PD1
Chen, F; Chen, M; Luo, C; Mo, Z; Shen, Q; Song, S; Wei, F; Wei, S1
Liu, X; Liu, Y; Wang, Y; Zhang, D; Zhang, W1
Chae, HJ; Jang, JB; Jeong, HJ; Kim, HM; Kim, KY; Kim, MH; Lee, JM; Nam, SY; Rah, SY1
Cheon, SM; Cho, HY; Ham, SH; Kim, SJ; Ko, SM; Kwon, YD; Lee, YB; Shin, H1
Fang, M; Li, R; Shang, J; Wang, S; Wang, Y; Yi, H; Zhang, D; Zhang, L; Zhao, A1
Bi, K; He, B; Hu, L; Jia, Y; Wan, S; Xiao, F; Xu, M; Yan, T1
Chen, ZX; Liu, MY; Wei, BB; Wei, MJ1
Chu, C; Fan, XX; Kou, JP; Li, F; Yu, BY; Zhang, Y1
Amujuri, D; Lakshma Nayak, V; Poornima, B; Purushotham, U; Sarma, AVS; Sirisha, K; Siva, B; Suresh Babu, K; Tiwari, AK1
Kong, L; Sun, H; Wang, XJ; Wang, XQ; Yu, JB; Zhang, AH; Zhang, QY1
Feng, YL; Li, W; Liu, KY; Liu, YL; Song, YG; Su, D; Yang, LJ1
Cheng, X; Ding, XY; Ji, JD; Lu, TL; Mao, CQ; Su, LL; Wang, LJ; Zhang, J1
Chang, YN; Guo, PP; Hao, HY; Hao, YM; Liu, QJ; Zhang, RJ; Zhi, ZJ; Zuo, HY1
Cho, HY; Ham, SH; Jang, JH; Jeong, SH; Lee, YB; Yang, SJ1
Feng, J; Li, T; Tan, Y; Tang, T; Xia, M; Yang, S; Zhao, H1
Atsumi, T; Makino, T; Ohtsuka, I; Yokogawa, T; Yokoyama, Y1
Freysdottir, J; Hanski, L; Karhu, E; Kortesoja, M; Olafsdottir, ES1
Li, PB; Liang, FY; Ouyang, XS; Pei, Z; Su, WW; Wang, JW1
Cao, JQ; Deng, ZW; Du, SS; Geng, ZF; Guo, SS; Liang, JY; Pang, X; Wang, Y1
Arken, N1
Bai, D; Cong, S; Yuan, X; Zhang, X; Zhao, Y1
Chen, W; Ding, Z; Guo, Y; Hu, J; Jiang, Y; Xiao, J; Zhang, B; Zhang, Y1
Fu, X; Li, J; Yu, Z; Zhu, P1
Bi, K; Gao, H; Li, Q; Liu, H; Liu, R; Lv, X; Xu, H; Zhang, M; Zhang, Q; Zhang, Y1
Bi, K; Cheng, X; Jia, Y; Jing, H; Qi, Y; Wu, B; Xiao, F; Yan, T1
Kou, J; Li, F; Wang, G; Wang, T; Yu, B; Zhang, Y1
Bruun, T; Hanski, L; Johansson, NG; Kortesoja, M; Taavitsainen, E1
An, Q; Chen, S; Fu, BD; Huang, JN; Li, JH; Peng, LY; Shen, HQ; Song, K; Wu, SC; Yi, PF; Yu, JL; Yuan, M1
Kou, JP; Lai, Q; Li, F; Liu, ZL; Wang, H; Yu, BY; Yuan, GY1
Bi, K; Cheng, X; Du, Y; Gong, G; Jia, Y; Qi, Y; Wu, B; Yan, T1
Lu, Y; Piao, Z; Song, L; Yao, L; Zhang, L2
Dong, X; Du, X; Hao, X; Lin, L; Ni, J; Qu, C; Wu, H; Xie, L; Yin, X; Zhang, L1
Ahn, SJ; In, S; Kim, E; Kim, HJ; Lee, A; Min, SS1
Lee, KG; Park, M1
Kou, J; Lai, Q; Li, F; Yang, W; Yu, B; Zhang, L; Zhang, Y1
Bi, K; Gong, G; Jia, Y; Li, Y; Sun, Y; Wu, B; Yan, T; Zhang, J1
Gao, H; Wang, X; Xu, Y; Zhang, S1
Acharekar, N; Alagaratnam, A; Kong, J; Yoganathan, S1
Kaifuchi, N; Matsumoto, T; Sakamoto, T; Setou, M; Takahashi, Y; Takiyama, M; Watanabe, J1
Aras, A; Attar, R; Butt, G; Farooqi, AA; Lin, X; Mobeen, I; Yulaevna, IM1
Cui, L; Huang, Q; Li, W; Liu, Y; Niu, X; Song, H; Yang, Y; Yu, J1
Bu, F; He, Q; Li, M; Lin, HS; Lin, J; Mak, WY; Tang, Z; Wang, Q; Xiang, X; Zhu, X; Zhuang, X1
Bi, K; Li, Q; Li, S; Xu, H; Yang, P; Zhang, Q; Zhang, Y1
Han, M; Hu, JN; Jiang, S; Li, HP; Li, W; Ren, S; Tang, S; Wang, YM; Wang, Z; Zhang, H1
Jung, UJ; Kim, SR; Park, HJ1
Kotlík, J; Maršálek, B; Maršálková, E; Opatřilová, R; Valíčková, J; Zezulka, Š1
Olas, B1
Cuc, NT; Cuong, NT; Dung, DT; Hoang, NH; Kiem, PV; Nhiem, NX; Tai, BH; Thanh Huong, PT; Thanh, BV; Yen, PH1
Choi, J; Hien, NTT; Hien, TTT; Kim, J; Kim, SH; Nhiem, NX; Tai, BH; Tai, PT; Thang, HD; Tram, LH; Tuan, HA; Tung, NM; Van Khoi, N; Van Kiem, P1
Ekiert, H; Jafernik, K; Szopa, A1
Jing, H; Li, H; Qiu, X; Song, H; Wang, C; Xu, M; Zhao, C; Zhuang, W1
Hu, H; Li, Y; Wang, Z; Xu, C; Yang, K; You, Y; Zhao, L; Zhou, W1
Fan, S; Ge, Y; Han, X; Lu, W; Shu, N; Tian, T; Xu, P; Yan, Y; Yang, Y1

Reviews

8 review(s) available for schizandrin and lignans

ArticleYear
Bioactivity of neolignans from fructus Schizandrae.
    Memorias do Instituto Oswaldo Cruz, 1991, Volume: 86 Suppl 2

    Topics: Alanine Transaminase; Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Lignin; Liver; Polycyclic Compounds

1991
[Biochemical and pharmacologic effects of wuweizi (Schizandra chinensis (Turcz.) Baill.) and its chemical contents on animal livers].
    Sheng li ke xue jin zhan [Progress in physiology], 1988, Volume: 19, Issue:3

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Lignans; Liver; Mitochondria, Liver; Polycyclic Compounds

1988
[Phytotherapeutic aspects of diseases of the circulatory system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and biological activity].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2001, Volume: 50, Issue:4

    Topics: Cardiovascular Diseases; Cyclooctanes; Humans; Lignans; Plant Extracts; Plants, Medicinal; Polycyclic Compounds

2001
Schisandra fruits for the management of drug-induced liver injury in China: A review.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 59

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; China; Cyclooctanes; Drugs, Chinese Herbal; Fruit; Humans; Lignans; Liver; Liver Regeneration; Phytotherapy; Polycyclic Compounds; Schisandra

2019
Ellagic Acid and Schisandrins: Natural Biaryl Polyphenols with Therapeutic Potential to Overcome Multidrug Resistance in Cancer.
    Cells, 2021, 02-21, Volume: 10, Issue:2

    Topics: Animals; Cyclooctanes; Drug Discovery; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ellagic Acid; Humans; Lignans; Neoplasms; Polycyclic Compounds; Polyphenols

2021
Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss".
    Cellular and molecular biology (Noisy-le-Grand, France), 2021, Sep-29, Volume: 67, Issue:2

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Movement; Clinical Trials as Topic; Cyclooctanes; Gene Expression Regulation, Neoplastic; Humans; Lignans; Neoplasms; Plant Extracts; Polycyclic Compounds; Protein Interaction Maps; Schisandra; Signal Transduction; Treatment Outcome

2021
Cardioprotective Potential of Berries of
    Nutrients, 2023, Jan-23, Volume: 15, Issue:3

    Topics: Anti-Inflammatory Agents; Antioxidants; Fruit; Lignans; Schisandra

2023
    Molecules (Basel, Switzerland), 2023, May-25, Volume: 28, Issue:11

    Topics: China; Cyclooctanes; Lignans; Schisandra

2023

Other Studies

173 other study(ies) available for schizandrin and lignans

ArticleYear
The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin.
    Chemical & pharmaceutical bulletin, 1979, Volume: 27, Issue:6

    Topics: Chemical Phenomena; Chemistry; Cyclooctanes; Cycloparaffins; Dioxoles; Lignans; Molecular Conformation; Plant Extracts; Plants, Medicinal; Polycyclic Compounds

1979
[Thin layer chromatographic studies on radix Ginseng, fructus Schisandrae and radix Salviae miltiorrhizae in yixinfumai granules].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1992, Volume: 17, Issue:4

    Topics: Chromatography, Thin Layer; Cyclooctanes; Dioxoles; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Lignans; Panax; Plants, Medicinal; Polycyclic Compounds; Saponins

1992
[Metabolic transformation of schizandrin].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1992, Volume: 27, Issue:1

    Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats

1992
[Effects of schizandrol A on monoamine neurotransmitters in the central nervous system].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1991, Volume: 13, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Corpus Striatum; Cyclooctanes; Dopamine; Hypothalamus; Lignans; Male; Neurotransmitter Agents; Polycyclic Compounds; Rats; Rats, Inbred Strains; Receptors, Dopamine

1991
[Antioxidation mechanism of schizandrin and tanshinonatic acid A and their effects on the protection of cardiotoxic action of adriamycin].
    Sheng li ke xue jin zhan [Progress in physiology], 1991, Volume: 22, Issue:4

    Topics: Animals; Cardiovascular Agents; Cyclooctanes; Doxorubicin; Drugs, Chinese Herbal; Free Radical Scavengers; Leukemia P388; Lignans; Malondialdehyde; Mitochondria, Heart; Phenanthrenes; Polycyclic Compounds

1991
Scavenging effect of schizandrins on active oxygen radicals.
    Cell biology international reports, 1990, Volume: 14, Issue:2

    Topics: Cyclooctanes; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Lignans; Lymphocyte Activation; Molecular Structure; Neutrophils; Oximetry; Oxygen Consumption; Polycyclic Compounds; Tetradecanoylphorbol Acetate

1990
Scavenging effects on active oxygen radicals by schizandrins with different structures and configurations.
    Free radical biology & medicine, 1990, Volume: 9, Issue:2

    Topics: Cyclooctanes; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Humans; Hydroxides; Hydroxyl Radical; Lignans; Neutrophils; Oxygen Consumption; Plants, Medicinal; Polycyclic Compounds; Superoxides

1990
[Determination of the active ingredients in Chinese drug wuweizi (Schisandra chinensis) by TLC-densitometry].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1990, Volume: 25, Issue:1

    Topics: Chromatography, Thin Layer; Cyclooctanes; Densitometry; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds

1990
Pharmacological actions and clinical use of fructus schizandrae.
    Chinese medical journal, 1989, Volume: 102, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Drugs, Chinese Herbal; Hepatitis B; Humans; Lignans; Lipid Peroxidation; Mice; Microsomes, Liver; Polycyclic Compounds; Rats

1989
[Preliminary studies on the processing of Schisandra chinensis].
    Zhong yao tong bao (Beijing, China : 1981), 1986, Volume: 11, Issue:3

    Topics: Acetates; Biological Availability; Cyclooctanes; Hot Temperature; Lignans; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oils, Volatile; Plants, Medicinal; Polycyclic Compounds

1986
[Induction of hepatic microsomal monooxygenases by schisanhenol in rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1985, Volume: 6, Issue:1

    Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Enzyme Induction; Lignans; Male; Mice; Microsomes, Liver; Oxygenases; Polycyclic Compounds; Rats; Rats, Inbred Strains

1985
[Experimental study on the enhancement of the immunosuppressive effect of cortisone by wurenchun, an extract of Schizandra chinensis Baill].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1985, Volume: 5, Issue:6

    Topics: Animals; Antibody Formation; Cortisone; Cyclooctanes; Female; Immunosuppressive Agents; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mice; Plants, Medicinal; Polycyclic Compounds; Rosette Formation

1985
[Pharmacological studies on an oil emulsion of Schisandra chinensis].
    Zhong yao tong bao (Beijing, China : 1981), 1984, Volume: 9, Issue:4

    Topics: Animals; Cyclic AMP; Cyclooctanes; Emulsions; Lignans; Liver; Mice; Polycyclic Compounds

1984
[Suppressive effect of wurenchun on the plaque forming cell (PFC) and specific rosette formation cell (SRFC) of mice].
    Zhonghua yi xue za zhi, 1984, Volume: 64, Issue:6

    Topics: Animals; Antibody-Producing Cells; Cyclooctanes; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Lignans; Male; Mice; Polycyclic Compounds; Rosette Formation

1984
[Metabolic fate of schizandrol A and its distribution in the rat brain determined by thin layer chromatography].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1983, Volume: 18, Issue:7

    Topics: Animals; Brain; Chromatography, Thin Layer; Cyclooctanes; Kinetics; Lignans; Male; Mice; Polycyclic Compounds; Rats

1983
[Effects of schizandrol on the central nervous system].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1983, Volume: 18, Issue:6

    Topics: Aggression; Animals; Anticonvulsants; Brain; Catalepsy; Cyclooctanes; Humans; Lignans; Male; Mice; Motor Activity; Polycyclic Compounds; Rats; Sleep

1983
Specific evidence that schizandrins induce a phenobarbital-like cytochrome P-450 form separated from rat liver.
    Biochemical and biophysical research communications, 1981, Dec-31, Volume: 103, Issue:4

    Topics: Animals; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxolanes; Dioxoles; Hydrocarbons, Chlorinated; Immunodiffusion; Lignans; Male; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats; Rats, Inbred Strains

1981
Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.
    Chemico-biological interactions, 1982, Volume: 39, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; In Vitro Techniques; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Microsomes, Liver; Mutagens; NADP; Oxidation-Reduction; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains

1982
Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids.
    Chemico-biological interactions, 1982, Jul-15, Volume: 41, Issue:1

    Topics: Animals; Carbon Tetrachloride; China; Cyclooctanes; Dioxoles; Lignans; Lipid Metabolism; Lipid Peroxides; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; NADP; Oxygen Consumption; Plants, Medicinal; Polycyclic Compounds

1982
[Pharmacological studies on schizandra fruits. II. Effects of constituents of shizandra fruits on drugs induced hepatic damage in rats].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1982, Volume: 102, Issue:6

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cycloparaffins; Drug Evaluation, Preclinical; Lignans; Liver Diseases; Male; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains

1982
[Synthesis of some derivatives of schizandrins (author's transl)].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1981, Volume: 16, Issue:12

    Topics: Alanine Transaminase; Animals; Cyclooctanes; Hepatitis, Viral, Human; Lignans; Mice; Polycyclic Compounds; Structure-Activity Relationship

1981
[Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1981, Volume: 101, Issue:11

    Topics: Animals; Cyclooctanes; Cycloparaffins; Dioxoles; Drug Synergism; Guinea Pigs; Hexobarbital; Lignans; Male; Methamphetamine; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains; Sleep

1981
Structure determination of biliary metabolites of schizandrin in rat and dog.
    Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:1

    Topics: Animals; Bile; Cyclooctanes; Dogs; Lignans; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Rats

1995
Determination of schizandrin in human plasma by gas chromatography-mass spectrometry.
    Journal of chromatography. B, Biomedical applications, 1995, Dec-15, Volume: 674, Issue:2

    Topics: Cyclooctanes; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Male; Plants, Medicinal; Polycyclic Compounds; Sensitivity and Specificity

1995
Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists.
    Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:3

    Topics: Biphenyl Compounds; Cyclooctanes; Esterification; Hydroxylation; Lignans; Plants, Medicinal; Platelet Activating Factor; Polycyclic Compounds; Structure-Activity Relationship

1999
Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:4

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Glutathione; Glutathione Reductase; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Polycyclic Compounds; Structure-Activity Relationship

1998
Effect of plant matrix and fluid ethanol concentration on supercritical fluid extraction efficiency of schisandrin derivatives.
    Journal of chromatographic science, 1999, Volume: 37, Issue:12

    Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Cyclooctanes; Ethanol; Fruit; Indicators and Reagents; Lignans; Plant Extracts; Plant Leaves; Plant Stems; Plants, Medicinal; Polycyclic Compounds; Solvents

1999
Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model.
    Journal of ethnopharmacology, 1999, Volume: 67, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Fruit; Hong Kong; Lignans; Liver; Liver Diseases; Male; Medicine, Chinese Traditional; Molecular Probes; Oxidation-Reduction; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Seeds

1999
Rapid microbore liquid chromatographic analysis of biphenyldimethyl dicarboxylate in human plasma with on-line column switching.
    Journal of chromatography. B, Biomedical sciences and applications, 2000, Jan-28, Volume: 738, Issue:1

    Topics: Chromatography, Liquid; Cyclooctanes; Dioxoles; Hepatitis, Chronic; Humans; Lignans; Male; Plants, Medicinal; Polycyclic Compounds

2000
Synthesis of the spirocyclic cyclohexadienone ring system of the schiarisanrins.
    Organic letters, 2000, Feb-10, Volume: 2, Issue:3

    Topics: Cyclooctanes; Lignans; Plants, Medicinal; Polycyclic Compounds; Spiro Compounds

2000
[Comparison of 4 extraction methods of chemical constituents in medicinal tea sishen chaji].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1997, Volume: 22, Issue:6

    Topics: Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Ficusin; Lignans; Plant Extracts; Polycyclic Compounds; Quinazolines; Technology, Pharmaceutical

1997
The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.
    Pharmacological research, 2001, Volume: 43, Issue:1

    Topics: Administration, Oral; Amnesia; Animals; Bicuculline; Cycloheximide; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; p-Chloroamphetamine; Phytotherapy; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurotransmitter; Ritanserin; Scopolamine; Water

2001
[Phytotherapeutic aspects of diseases of the circulatory system. 8. Chinese magnolia (Schisandra chinensis (Turcz.) Baill.): production of the drugs and their evaluation, therapeutic and dietary preparations].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2001, Volume: 50, Issue:5

    Topics: Cardiovascular Diseases; Cyclooctanes; Humans; Lignans; Plant Extracts; Plants, Medicinal; Polycyclic Compounds

2001
[Total synthesis of schizandrin, the main active ingredient isolated from the Chinese herbal medicine fructus schizandrae].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:6

    Topics: Cyclooctanes; Lignans; Molecular Structure; Polycyclic Compounds; Schisandra

1998
[A new bibenzyl derivative from Bletilla striata].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:3

    Topics: Bibenzyls; Cyclooctanes; Lignans; Molecular Structure; Orchidaceae; Plant Roots; Plants, Medicinal; Polycyclic Compounds

2002
Total synthesis of (+)-isoschizandrin utilizing a samarium(II) iodide-promoted 8-endo ketyl-olefin cyclization.
    The Journal of organic chemistry, 2003, Dec-12, Volume: 68, Issue:25

    Topics: Alkenes; Aza Compounds; Boron Compounds; Cyclization; Cyclooctanes; Iodides; Ketones; Lactones; Lignans; Models, Chemical; Molecular Structure; Polycyclic Compounds; Samarium; Schisandra; Stereoisomerism

2003
Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
    Journal of neuroscience research, 2004, May-01, Volume: 76, Issue:3

    Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Glutamic Acid; Intracellular Fluid; Lignans; Neurons; Neuroprotective Agents; Neurotoxins; Peroxides; Phytotherapy; Plant Extracts; Polycyclic Compounds; Rats; Schisandra

2004
[Studies on extraction process of Fructus Schisandrae chinensis and Fructus Ligustri lucidi in gandening tablet].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2004, Volume: 29, Issue:8

    Topics: Alcohols; Chemistry, Pharmaceutical; Chromatography, Supercritical Fluid; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Fruit; Lignans; Ligustrum; Plants, Medicinal; Polycyclic Compounds; Schisandra; Technology, Pharmaceutical

2004
[Study on the simultaneous spectrophotometric determination of three components including deoxyschizandrin by ridge regression method].
    Guang pu xue yu guang pu fen xi = Guang pu, 2004, Volume: 24, Issue:10

    Topics: Cyclooctanes; Lignans; Polycyclic Compounds; Regression Analysis; Spectrophotometry

2004
Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis.
    Journal of chromatography. A, 2005, Aug-05, Volume: 1082, Issue:2

    Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds; Schisandra

2005
Determination of schizandrin in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Dec-15, Volume: 828, Issue:1-2

    Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Stability; Lignans; Mass Spectrometry; Polycyclic Compounds; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2005
[Deterimination of schisandrin in Kadsura heteroclita (Roxb.) Craib by RP-HPLC].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2006, Volume: 29, Issue:6

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Kadsura; Lignans; Plant Stems; Plants, Medicinal; Polycyclic Compounds; Quality Control; Reproducibility of Results

2006
[Relationship between components changes and efficacy of Shengmaisan VII. Chemical dynamic change of schisandrin in Shengmaisan].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:12

    Topics: Cyclooctanes; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; Ginsenosides; Lignans; Ophiopogon; Panax; Plants, Medicinal; Polycyclic Compounds; Schisandra

2006
Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:1

    Topics: alpha-Tocopherol; Amyloid beta-Peptides; Animals; Apoptosis; bcl-Associated Death Protein; Caspase 3; Caspase Inhibitors; Cell Survival; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Flow Cytometry; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase-1; Lignans; MAP Kinase Kinase 4; Oxidation-Reduction; PC12 Cells; Polycyclic Compounds; Rats; Time Factors

2007
Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:6

    Topics: Animals; Anti-Allergic Agents; Cyclooctanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Interleukin-4; Lignans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Molecular Structure; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Plant Extracts; Polycyclic Compounds; Pruritus; Schisandra; Tumor Necrosis Factor-alpha

2007
Schizandrin reverses memory impairment in rats.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:1

    Topics: Animals; Avoidance Learning; Cyclooctanes; Dose-Response Relationship, Drug; Lignans; Male; Maze Learning; Memory Disorders; Molecular Structure; Muscarinic Antagonists; Oxotremorine; Phytotherapy; Polycyclic Compounds; Rats; Rats, Wistar; Schisandra; Scopolamine

2008
[Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:7

    Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Cyclooctanes; Enzyme Inhibitors; Female; In Vitro Techniques; Ketoconazole; Lignans; Male; Microsomes, Liver; Orphenadrine; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Sex Factors; Spectrophotometry, Ultraviolet

2007
Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:2

    Topics: Apoptosis; Caspase 3; Cell Survival; Cyclooctanes; DNA Fragmentation; HL-60 Cells; Humans; Lignans; Molecular Biology; Phytotherapy; Plant Preparations; Polycyclic Compounds; Schisandra; Structure-Activity Relationship

2008
Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats.
    Journal of ethnopharmacology, 2008, Feb-12, Volume: 115, Issue:3

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, Liquid; Cyclooctanes; Drugs, Chinese Herbal; Female; Fruit; Half-Life; Lignans; Mass Spectrometry; Medicine, Chinese Traditional; Ophiopogon; Panax; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Solubility; Time Factors

2008
Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:6

    Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclooctanes; Dioxoles; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fruit; Genes, MDR; Humans; Lignans; Mice; Mice, Nude; Neoplasm Proteins; Phytotherapy; Plant Preparations; Polycyclic Compounds; Protein Kinase C; Schisandra; Xenograft Model Antitumor Assays

2008
Neglschisandrins A-B: two new dibenzocyclooctene lignans from Schisandra neglecta.
    Molecules (Basel, Switzerland), 2008, Mar-03, Volume: 13, Issue:3

    Topics: Cyclooctanes; Lignans; Magnetic Resonance Spectroscopy; Polycyclic Compounds; Schisandra

2008
Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity.
    Journal of pharmacological sciences, 2008, Volume: 107, Issue:1

    Topics: Animals; Apoptosis; Calcium; Caspases; Cells, Cultured; Cerebral Cortex; Cyclooctanes; Cytochromes c; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Lignans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Poly(ADP-ribose) Polymerases; Polycyclic Compounds; Rats; Reactive Oxygen Species

2008
Neglschisandrins C-D: two new dibenzocyclooctadiene lignans from Schisandra neglecta.
    Molecules (Basel, Switzerland), 2008, May-13, Volume: 13, Issue:5

    Topics: Cyclooctanes; Lignans; Magnetic Resonance Spectroscopy; Polycyclic Compounds; Schisandra

2008
Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill.
    European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Cell Line; Cyclooctanes; Cyclooxygenase 2; Dinoprostone; Fruit; Gene Expression Regulation; Inflammation; Lignans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Polycyclic Compounds; Schisandra; Sepsis

2008
Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzocyclooctadiene lignan.
    Journal of natural products, 2008, Volume: 71, Issue:9

    Topics: Cyclooctanes; Lignans; Masoprocol; Molecular Structure; Oxidation-Reduction; Polycyclic Compounds; Stereoisomerism

2008
Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.
    Phytotherapy research : PTR, 2009, Volume: 23, Issue:2

    Topics: Alkaline Phosphatase; Animals; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Cyclooctanes; Enzyme Activators; Lignans; Osteoblasts; Plant Extracts; Polycyclic Compounds; Rats; Schisandra

2009
[Lignans from different processed products of Schisandra chinensis fruits].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:6

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drug Compounding; Drugs, Chinese Herbal; Fruit; Hot Temperature; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra; Spectrometry, Mass, Electrospray Ionization

2008
Nortriterpenoids and lignans from Schisandra sphenanthera.
    Phytochemistry, 2008, Volume: 69, Issue:16

    Topics: Cell Line; Cyclooctanes; Dioxoles; HeLa Cells; HIV-1; Humans; Lignans; Microbial Sensitivity Tests; Plant Extracts; Polycyclic Compounds; Schisandra; Triterpenes

2008
[Effects of schisandra on the function of the pituitary-adrenal cortex, gonadal axis and carbohydrate metabolism in rats undergoing experimental chronic psychological stress, navigation and strenuous exercise].
    Zhonghua nan ke xue = National journal of andrology, 2009, Volume: 15, Issue:2

    Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Corticosterone; Cyclooctanes; Hyperkinesis; Lignans; Male; Physical Conditioning, Animal; Phytotherapy; Pituitary-Adrenal System; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Stress, Psychological

2009
Inhibitory effects of Schizandrae Fructus on eotaxin secretion in A549 human epithelial cells and eosinophil migration.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:9

    Topics: Cell Line; Cell Migration Inhibition; Chemokines, CC; Chemotaxis, Leukocyte; Cyclooctanes; Cytokines; Eosinophilia; Eosinophils; Epithelial Cells; Fruit; Humans; Intercellular Adhesion Molecule-1; Lignans; Lung; Plant Extracts; Polycyclic Compounds; Respiratory Mucosa; RNA, Messenger; Schisandra; Vascular Cell Adhesion Molecule-1

2009
Effects of schisandrin on transcriptional factors in lipopolysaccharide-pretreated macrophages.
    Archives of pharmacal research, 2009, Volume: 32, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooctanes; Cyclooxygenase 2; Dose-Response Relationship, Drug; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Lignans; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polycyclic Compounds; Time Factors; Transcription Factors

2009
Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclooctanes; Female; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Schisandra

2010
[Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 2009, Volume: 27, Issue:3

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds; Schisandra

2009
Highly sensitive determination of Schisandrin and Schisandrin B in plasma of rats after administration of Wurenchun (Fructus Schisandrae Chinensis Extracts) preparations by LC-ESI-MS/MS.
    Biomedical chromatography : BMC, 2010, Volume: 24, Issue:6

    Topics: Animals; Chromatography, Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2010
CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2010, Volume: 40, Issue:1

    Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Ketoconazole; Lignans; Mass Spectrometry; Metabolic Networks and Pathways; Microsomes, Liver; Polycyclic Compounds; Rats; Swine; Swine, Miniature; Troleandomycin

2010
[Preparation of enteric nanoparticles of Schisandra total lignanoids and preliminary study on its pharmacokinetics].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2009, Volume: 44, Issue:9

    Topics: Animals; Area Under Curve; Biological Availability; Cyclooctanes; Female; Lignans; Male; Nanoparticles; Particle Size; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra

2009
A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera.
    Analytica chimica acta, 2010, Mar-03, Volume: 662, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Lignans; Mass Spectrometry; Plant Extracts; Polycyclic Compounds; Reproducibility of Results; Schisandra

2010
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.
    Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7

    Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Circular Dichroism; Cyclooctanes; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Indicators and Reagents; Leukotriene B4; Lignans; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

2010
[Changes of lignans' content in stems of Schisandra chinensis].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:24

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Plant Stems; Polycyclic Compounds; Schisandra

2009
Anti-asthmatic effect of schizandrin on OVA-induced airway inflammation in a murine asthma model.
    International immunopharmacology, 2010, Volume: 10, Issue:11

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclooctanes; Cytokines; Disease Models, Animal; Eosinophils; Female; Goblet Cells; Hyperplasia; Immunoglobulin E; Lignans; Lung; Mice; Mice, Inbred BALB C; Oxidative Stress; Polycyclic Compounds; Reactive Oxygen Species; Th1 Cells; Th2 Cells

2010
Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cyclooctanes; Dioxoles; Homocysteine; Lignans; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Polycyclic Compounds; Rats; Reactive Oxygen Species; Schisandra

2011
Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems.
    Drug development and industrial pharmacy, 2010, Volume: 36, Issue:11

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Cyclooctanes; Drug Delivery Systems; Drugs, Chinese Herbal; Emulsions; Excipients; Fruit; Lignans; Male; Particle Size; Plant Extracts; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Solubility

2010
[The effect of the stimulator-schizandra on neuro-muscular excitability in man].
    Biulleten' eksperimental'noi biologii i meditsiny, 1945, Volume: 19, Issue:4

    Topics: Cyclooctanes; Humans; Lignans; Muscles; Polycyclic Compounds; Schisandra

1945
Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons.
    Journal of the science of food and agriculture, 2011, Mar-15, Volume: 91, Issue:4

    Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Protein; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclooctanes; Dendrites; Fruit; Hippocampus; Lignans; Mitogen-Activated Protein Kinase Kinases; Neurogenesis; Phosphorylation; Plant Extracts; Polycyclic Compounds; Post-Synaptic Density; Presynaptic Terminals; Protein Kinase C-epsilon; Rats; Rats, Wistar; Schisandra

2011
Schiglautone A, a new tricyclic triterpenoid with a unique 6/7/9-fused skeleton from the stems of Schisandra glaucescens.
    Organic letters, 2011, Mar-18, Volume: 13, Issue:6

    Topics: Crystallography, X-Ray; Cyclooctanes; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Stems; Polycyclic Compounds; Schisandra; Triterpenes

2011
Study on ionic liquid-based ultrasonic-assisted extraction of biphenyl cyclooctene lignans from the fruit of Schisandra chinensis Baill.
    Analytica chimica acta, 2011, Mar-09, Volume: 689, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Fruit; Ionic Liquids; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Solid Phase Extraction; Time Factors; Ultrasonics

2011
Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Aug-15, Volume: 18, Issue:11

    Topics: Adrenergic Antagonists; Animals; Atropine; Benzyl Compounds; Colon, Ascending; Cyclic GMP; Cyclooctanes; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Lignans; Male; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Phentolamine; Plant Extracts; Polycyclic Compounds; Propranolol; Purinergic Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Schisandra; Tetrodotoxin; Xanthines

2011
Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
    Molecules (Basel, Switzerland), 2011, May-03, Volume: 16, Issue:5

    Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds

2011
Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages.
    Immunology letters, 2011, Sep-30, Volume: 139, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Nucleus; Cyclooctanes; Enzyme Activation; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Lignans; Lipopolysaccharides; Macrophages; Mice; NF-E2-Related Factor 2; NF-kappa B; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Porphyromonas gingivalis; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; Up-Regulation

2011
Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Oct-15, Volume: 18, Issue:13

    Topics: Acetylcholine; Animals; Calcium; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Guinea Pigs; Ileum; In Vitro Techniques; Lignans; Male; Muscle Contraction; Muscle Relaxants, Central; Parasympatholytics; Plant Extracts; Plants, Medicinal; Polycyclic Compounds; Receptor, Muscarinic M3; Schisandra; Serotonin

2011
Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Nov-15, Volume: 879, Issue:30

    Topics: Adsorption; Analysis of Variance; Chromatography, Ion Exchange; Cyclooctanes; Dioxoles; Ethanol; Fruit; Hydrolysis; Ion Exchange Resins; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Temperature

2011
Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:3-4

    Topics: Animals; Cell Line, Transformed; Cell Proliferation; Collagen Type IV; Cyclooctanes; Fibronectins; Glomerular Mesangium; Glucose; Lignans; MAP Kinase Signaling System; Mice; NADPH Oxidases; Phosphorylation; Polycyclic Compounds; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta1

2012
[Effects of schizandrins on learning-memory disorder in mice].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011, Volume: 36, Issue:23

    Topics: Animals; Apoptosis; Behavior, Animal; CA1 Region, Hippocampal; Caspase 3; Cell Line; Cyclooctanes; Disease Models, Animal; Drugs, Chinese Herbal; Female; Learning Disabilities; Lignans; Male; Memory Disorders; Mice; Nitric Oxide; Oxidative Stress; PC12 Cells; Polycyclic Compounds; Proto-Oncogene Proteins c-bcl-2; Rats; Superoxide Dismutase; Transcription Factor RelA

2011
[Pharmacokinetics interaction among three major active compounds of Shengmai formula in rats].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2012, Volume: 41, Issue:1

    Topics: Animals; Biological Availability; Chromatography, Liquid; Cyclooctanes; Drug Synergism; Ginsenosides; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2012
[Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011, Volume: 34, Issue:12

    Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cyclooctanes; Fruit; Kidney; Lignans; Liver; Lung; Male; Mice; Plant Extracts; Polycyclic Compounds; Schisandra; Spleen; Tissue Distribution

2011
[Study on the chemical constituents of vinegar Schisandra chinensis].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011, Volume: 34, Issue:11

    Topics: Acetic Acid; Cyclooctanes; Fruit; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Schisandra; Sitosterols; Technology, Pharmaceutical

2011
Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice.
    Oxidative medicine and cellular longevity, 2012, Volume: 2012

    Topics: Amyloid beta-Peptides; Animals; Antioxidants; Biological Assay; Cerebral Cortex; Cyclooctanes; Hippocampus; Lignans; Male; Maze Learning; Memory Disorders; Mice; Motor Activity; Peptide Fragments; Polycyclic Compounds; Reaction Time; Schisandra

2012
Effects of schizandrin on the expression of thymic stromal lymphopoietin in human mast cell line HMC-1.
    Life sciences, 2012, Oct-05, Volume: 91, Issue:11-12

    Topics: Blotting, Western; Calcimycin; Caspase 1; Cell Line; Cyclooctanes; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Lignans; Luciferases; Mast Cells; Polycyclic Compounds; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Thymic Stromal Lymphopoietin

2012
Schizandrin prevents dexamethasone-induced cognitive deficits.
    Neuroscience bulletin, 2012, Volume: 28, Issue:5

    Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebral Cortex; Cognition Disorders; Cyclooctanes; Dexamethasone; Dose-Response Relationship, Drug; Lignans; Male; Mice; Neuroprotective Agents; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra

2012
Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity.
    Lipids in health and disease, 2012, Sep-19, Volume: 11

    Topics: Animals; Cyclooctanes; Diet; Drugs, Chinese Herbal; Fenofibrate; Fruit; Hypercholesterolemia; Hypolipidemic Agents; Lignans; Lipid Metabolism; Lipids; Liver; Mice; Polycyclic Compounds; Triglycerides

2012
[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:7

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra

2012
Schizandrin protects primary rat cortical cell cultures from glutamate-induced apoptosis by inhibiting activation of the MAPK family and the mitochondria dependent pathway.
    Molecules (Basel, Switzerland), 2012, Dec-27, Volume: 18, Issue:1

    Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Caspase 12; Cells, Cultured; Cerebral Cortex; Cyclooctanes; Fas Ligand Protein; fas Receptor; Glutamic Acid; Lignans; Mitochondria; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Phosphorylation; Polycyclic Compounds; Primary Cell Culture; Signal Transduction; Tumor Suppressor Protein p53

2012
Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
    Journal of separation science, 2013, Volume: 36, Issue:3

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization

2013
Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats.
    Journal of pharmaceutical and biomedical analysis, 2013, Apr-15, Volume: 77

    Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Medicine, Chinese Traditional; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Sensitivity and Specificity; Sleep Initiation and Maintenance Disorders; Tandem Mass Spectrometry

2013
Neglschisandrins E-F: two new lignans and related cytotoxic lignans from Schisandra neglecta.
    Molecules (Basel, Switzerland), 2013, Feb-19, Volume: 18, Issue:2

    Topics: Cell Death; Cell Line, Tumor; Cyclooctanes; Drug Screening Assays, Antitumor; Humans; Lignans; Magnetic Resonance Spectroscopy; Models, Molecular; Polycyclic Compounds; Schisandra

2013
Effect of acupuncture on target tissue distribution of Schisandra lignans.
    Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2013, Volume: 31, Issue:2

    Topics: Acupuncture Therapy; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Polycyclic Compounds; Rats; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Tissue Distribution

2013
Ultra-performance liquid-chromatography with tandem mass spectrometry for rapid analysis of pharmacokinetics, biodistribution and excretion of schisandrin after oral administration of Shengmaisan.
    Biomedical chromatography : BMC, 2013, Volume: 27, Issue:12

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Feces; Lignans; Male; Organ Specificity; Polycyclic Compounds; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2013
Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:5

    Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; Microsomes, Liver; Plants, Medicinal; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2013
Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:12

    Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Cycle; Cell Line; Cell Survival; Cisplatin; Collagen; Cyclooctanes; Epithelial Cells; Fruit; Humans; Kidney Tubules, Proximal; Lignans; Molecular Structure; Polycyclic Compounds; Protective Agents; Schisandra

2014
Effects of drugs on exercise performance.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:5

    Topics: Administration, Oral; Animals; Animals, Outbred Strains; Antioxidants; Central Nervous System Stimulants; Cyclooctanes; Imidazoles; Lignans; Organometallic Compounds; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Polycyclic Compounds; Rats; Swimming

2013
A pharmacokinetic and pharmacodynamic study of drug-drug interaction between ginsenoside Rg1, ginsenoside Rb1 and schizandrin after intravenous administration to rats.
    Journal of ethnopharmacology, 2014, Mar-14, Volume: 152, Issue:2

    Topics: Administration, Intravenous; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Interactions; Drug Synergism; Ginsenosides; Half-Life; Lignans; Male; Medicine, Chinese Traditional; Models, Biological; Nitric Oxide; Panax; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra

2014
Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis).
    Biomedical chromatography : BMC, 2014, Volume: 28, Issue:8

    Topics: Acupuncture Therapy; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Linear Models; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution

2014
Simultaneous determination of calycosin-7-O-β-d-glucoside, calycosin, formononetin, astragaloside IV and schisandrin in rat plasma by LC-MS/MS: application to a pharmacokinetic study after oral administration of Shenqi Wuwei chewable tablets.
    Biomedical chromatography : BMC, 2014, Volume: 28, Issue:8

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Stability; Drugs, Chinese Herbal; Glucosides; Isoflavones; Lignans; Linear Models; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Triterpenes

2014
[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:1

    Topics: Countercurrent Distribution; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways.
    Journal of neuroscience research, 2014, Volume: 92, Issue:10

    Topics: Adenine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autophagy; Brain; Brain Infarction; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Infarction, Middle Cerebral Artery; Lignans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Polycyclic Compounds; Renal Circulation; Reperfusion Injury; Saponins; Time Factors; TOR Serine-Threonine Kinases

2014
Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease.
    Chinese journal of natural medicines, 2014, Volume: 12, Issue:4

    Topics: Animals; Cerebrovascular Disorders; Cyclooctanes; Drugs, Chinese Herbal; Gene Regulatory Networks; Humans; Lignans; Molecular Targeted Therapy; PC12 Cells; Polycyclic Compounds; Protein Interaction Maps; Rats; Signal Transduction

2014
[Determination of five components in rongxin pills by HPLC].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:6

    Topics: Abietanes; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Linear Models; Organic Chemicals; Phenanthrenes; Polycyclic Compounds; Quality Control; Reproducibility of Results

2014
A metabonomic study of cardioprotection of ginsenosides, schizandrin, and ophiopogonin D against acute myocardial infarction in rats.
    BMC complementary and alternative medicine, 2014, Sep-23, Volume: 14

    Topics: Animals; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Lignans; Magnetic Resonance Spectroscopy; Male; Metabolome; Metabolomics; Myocardial Infarction; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Saponins; Spirostans

2014
The beneficial effects of combined grape pomace and omija fruit extracts on hyperglycemia, adiposity and hepatic steatosis in db/db mice: a comparison with major index compounds.
    International journal of molecular sciences, 2014, Sep-30, Volume: 15, Issue:10

    Topics: Adiponectin; Adiposity; Animals; Biomarkers; Blood Glucose; Cyclooctanes; Diabetes Mellitus, Experimental; Fatty Liver; Fruit; Glycated Hemoglobin; Hyperglycemia; Insulin; Leptin; Lignans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Plant Extracts; Polycyclic Compounds; Resistin; Resveratrol; Schisandra; Stilbenes; Vitis

2014
Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice.
    European journal of pharmacology, 2014, Dec-05, Volume: 744

    Topics: 5-Hydroxytryptophan; Animals; Caffeine; Cyclooctanes; Fenclonine; Flumazenil; Fruit; GABA Antagonists; Hypnotics and Sedatives; Lignans; Locomotion; Male; Mice; Pentobarbital; Polycyclic Compounds; Sleep

2014
[Network analysis of ethanol precipitation process for Schisandrae chinensis fructus].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:17

    Topics: Bayes Theorem; Chemical Precipitation; Cold Temperature; Cyclooctanes; Ethanol; Fructose; Fruit; Glucose; Lignans; Neural Networks, Computer; Polycyclic Compounds; Reproducibility of Results; Schisandra; Time Factors

2014
Schizandrin ameliorates ovariectomy-induced memory impairment, potentiates neurotransmission and exhibits antioxidant properties.
    British journal of pharmacology, 2015, Volume: 172, Issue:10

    Topics: Acetylcholinesterase; Animals; Antioxidants; Avoidance Learning; Cell Count; Cyclooctanes; Excitatory Postsynaptic Potentials; Female; GPI-Linked Proteins; Hippocampus; Lignans; Long-Term Potentiation; Malondialdehyde; Memory Disorders; Ovariectomy; Polycyclic Compounds; Rats; Superoxide Dismutase; Synaptic Transmission

2015
Schizandrin inhibits fibrosis and epithelial-mesenchymal transition in transforming growth factor-β1-stimulated AML12 cells.
    International immunopharmacology, 2015, Volume: 25, Issue:2

    Topics: Animals; Cell Line; Cyclooctanes; Epithelial-Mesenchymal Transition; Fibrosis; Lignans; Liver Diseases; Mice; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; RNA, Small Interfering; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transforming Growth Factor beta1

2015
[Determination of lignanoids in seeds of Schisandra chinensis by combinative methods of fingerprint and QAMS].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:9

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds; Reproducibility of Results; Schisandra; Seeds

2014
Inhibitory effects of emodin, baicalin, schizandrin and berberine on hefA gene: treatment of Helicobacter pylori-induced multidrug resistance.
    World journal of gastroenterology, 2015, Apr-14, Volume: 21, Issue:14

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Berberine; Cyclooctanes; Drug Resistance, Multiple, Bacterial; Drugs, Chinese Herbal; Emodin; Flavonoids; Gene Expression Regulation, Bacterial; Helicobacter pylori; Lignans; Membrane Transport Proteins; Microbial Sensitivity Tests; Polycyclic Compounds; RNA, Messenger

2015
[Study on chemical constituents from Schisandra chinensis stem].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:10

    Topics: Cyclooctanes; Guaiacol; Lignans; Phytochemicals; Plant Stems; Polycyclic Compounds; Schisandra; Sitosterols

2014
[Chemical constituents from supercritical CO2 extraction of Schisandra chinensis].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:11

    Topics: Cyclooctanes; Lignans; Phytochemicals; Polycyclic Compounds; Schisandra; Sitosterols

2014
Isolation of three dibenzocyclooctadiene lignans from in vitro cultures of Schisandra chinensis (Turcz.) Baill.--the first report.
    Die Pharmazie, 2015, Volume: 70, Issue:5

    Topics: Cells, Cultured; Chromatography, Thin Layer; Cyclooctanes; Dioxoles; Lignans; Magnetic Resonance Spectroscopy; Plant Leaves; Plant Shoots; Polycyclic Compounds; Schisandra

2015
Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:10

    Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glucuronosyltransferase; Herb-Drug Interactions; Lignans; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Structure-Activity Relationship

2015
Identification of schisandrin as a vascular endothelium protective component in YiQiFuMai Powder Injection using HUVECs binding and HPLC-DAD-Q-TOF-MS/MS analysis.
    Journal of pharmacological sciences, 2015, Volume: 129, Issue:1

    Topics: Apoptosis; Cardiovascular Agents; Cell Hypoxia; Cell Survival; Chromatography, High Pressure Liquid; Cyclooctanes; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Ginsenosides; Human Umbilical Vein Endothelial Cells; Humans; L-Lactate Dehydrogenase; Lignans; Malondialdehyde; Nitric Oxide; Polycyclic Compounds; Reactive Oxygen Species; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2015
An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases.
    Acta pharmacologica Sinica, 2015, Volume: 36, Issue:11

    Topics: Animals; Brain Ischemia; Cell Line; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Humans; Lignans; Myocardial Ischemia; NF-kappa B; Oxidative Stress; PC12 Cells; Polycyclic Compounds; Protein Interaction Maps; Rats; Saponins; Signal Transduction; Systems Biology; Tumor Necrosis Factor-alpha

2015
The Effect of Schizandrol A-Induced DNA Methylation on SH-SY5YAB 1-40 Altered Neuronal Cell Line: A Potential Use in Alzheimer's Disease.
    Journal of toxicology and environmental health. Part A, 2015, Volume: 78, Issue:21-22

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cell Survival; Cyclooctanes; DNA Methylation; Gene Expression Regulation; Humans; Lignans; Neurons; Peptide Fragments; Polycyclic Compounds; Real-Time Polymerase Chain Reaction; RNA, Messenger

2015
Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission.
    Scientific reports, 2016, 11-21, Volume: 6

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; Cyclooctanes; Drug Combinations; Drug Therapy, Combination; Drugs, Chinese Herbal; Dynamins; Ginsenosides; Lignans; Male; Mice, Inbred ICR; Mitochondrial Dynamics; Myocardial Reperfusion Injury; Polycyclic Compounds; Spirostans

2016
Schisandra chinensis and Its Main Constituent Schizandrin Attenuate Allergic Reactions by Down-Regulating Caspase-1 in Ovalbumin-Sensitized Mice.
    The American journal of Chinese medicine, 2017, Volume: 45, Issue:1

    Topics: Animals; Caspase 1; Cyclooctanes; Down-Regulation; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Interleukin-1beta; Interleukin-4; Interleukin-6; Lignans; Mice; Ovalbumin; Plant Extracts; Polycyclic Compounds; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Schisandra; Spleen; Tumor Necrosis Factor-alpha

2017
Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies.
    Biomedical chromatography : BMC, 2017, Volume: 31, Issue:10

    Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Emodin; Female; Flavanones; Flavonoids; Glucosides; Lignans; Limit of Detection; Linear Models; Male; Monoterpenes; Polycyclic Compounds; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry

2017
Study on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:4

    Topics: Animals; Caco-2 Cells; Catechin; Cyclooctanes; Female; Humans; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tea

2018
Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooctanes; Cyclooxygenase 2; Cytokines; Dioxoles; Ethnopharmacology; Gene Expression Regulation; Lignans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Medicine, Korean Traditional; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Polycyclic Compounds; Prostatitis; Thioglycolates

2017
A sensitive UHPLC-MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study.
    Journal of separation science, 2017, Volume: 40, Issue:17

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Polycyclic Compounds; Reproducibility of Results; Tandem Mass Spectrometry

2017
Development and validation of an LC-MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription.
    Biomedical chromatography : BMC, 2018, Volume: 32, Issue:2

    Topics: Animals; Benzaldehydes; Benzofurans; Catechols; Chromatography, Liquid; Cyclooctanes; Drug Stability; Drugs, Chinese Herbal; Flavonoids; Lignans; Limit of Detection; Linear Models; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry

2018
Schisandrin rescues depressive-like behaviors induced by chronic unpredictable mild stress via GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in mice.
    Psychiatry research, 2017, Volume: 257

    Topics: Animals; Antidepressive Agents; Cyclooctanes; Depression; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Lignans; Male; MAP Kinase Signaling System; Mice; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Stress, Psychological; Swimming

2017
Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice: involvement of adjusting neurotransmitters and their metabolite changes in the brain.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Chromatography, Liquid; Cognitive Dysfunction; Cyclooctanes; Female; Hippocampus; Lignans; Male; Maze Learning; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Neurotransmitter Agents; Nootropic Agents; Polycyclic Compounds; Presenilin-1; Tandem Mass Spectrometry

2018
A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:4

    Topics: Animals; Creatine Kinase, MB Form; Cyclooctanes; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Heart; Isoproterenol; L-Lactate Dehydrogenase; Lignans; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Pituitary Hormones, Posterior; Polycyclic Compounds; Spirostans; Troponin I

2018
Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents.
    European journal of medicinal chemistry, 2018, Apr-10, Volume: 149

    Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooctanes; Drug Screening Assays, Antitumor; G2 Phase; Humans; Inhibitory Concentration 50; Lignans; Molecular Docking Simulation; Polycyclic Compounds; Structure-Activity Relationship

2018
Identifying quality-markers from Shengmai San protects against transgenic mouse model of Alzheimer's disease using chinmedomics approach.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Jun-01, Volume: 45

    Topics: Alzheimer Disease; Animals; Biomarkers, Pharmacological; Cyclooctanes; Dioxoles; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Lignans; Male; Medicine, Chinese Traditional; Metabolomics; Mice, Transgenic; Neuroprotective Agents; Polycyclic Compounds

2018
[Rapid identification of the different constituents in Fructus Schisandrae Chinensis before and after processing by UHPLC-QTOF/MS~E combining with metabonomics].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:9

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Metabolomics; Polycyclic Compounds; Schisandra

2016
[Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:10

    Topics: Acetic Acid; Animals; Bile; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Feces; Lignans; Liver Diseases, Alcoholic; Plasma; Polycyclic Compounds; Rats; Schisandra; Urine

2016
Protective effects of Schisandrin on high glucose-induced changes of RhoA and eNOS activity in human umbilical vein endothelial cells.
    Pathology, research and practice, 2018, Volume: 214, Issue:9

    Topics: Cyclooctanes; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Lignans; Nitric Oxide Synthase Type III; Polycyclic Compounds; rhoA GTP-Binding Protein

2018
Simultaneous UPLC-MS/MS determination of four components of Socheongryong-tang tablet in human plasma: Application to pharmacokinetic study.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Sep-15, Volume: 1095

    Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Cinnamates; Cyclooctanes; Drugs, Chinese Herbal; Ephedrine; Glucosides; Humans; Lignans; Linear Models; Male; Middle Aged; Monoterpenes; Polycyclic Compounds; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Young Adult

2018
[Analysis of traditional Chinese medicine components by high performance liquid chromatography with diode array detection based on double qualitative principles].
    Se pu = Chinese journal of chromatography, 2018, Aug-08, Volume: 36, Issue:8

    Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds

2018
Effects of crushed Schisandra Fruit on the content of lignans in Kampo decoction.
    Journal of natural medicines, 2019, Volume: 73, Issue:2

    Topics: Adult; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Fruit; Humans; Lignans; Male; Medicine, Kampo; Polycyclic Compounds; Schisandra; Taste; Young Adult

2019
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells.
    Free radical biology & medicine, 2019, 02-01, Volume: 131

    Topics: B7-2 Antigen; Chlamydophila pneumoniae; Coculture Techniques; Cyclooctanes; Dendritic Cells; Gene Expression; Glutathione; HLA-DR Antigens; Humans; Immunologic Factors; Interleukin-10; Interleukin-12; Interleukin-6; Lignans; Lipopolysaccharides; Lymphocyte Activation; Oxidation-Reduction; Polycyclic Compounds; Primary Cell Culture; Reactive Oxygen Species; Schisandra; T-Lymphocytes; THP-1 Cells

2019
Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling.
    Chinese journal of natural medicines, 2018, Volume: 16, Issue:12

    Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Central Nervous System Agents; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Zebrafish

2018
Chemical constituents isolated from stems of
    Natural product research, 2020, Volume: 34, Issue:18

    Topics: Animals; Cyclooctanes; Dioxoles; Feeding Behavior; Lignans; Plant Stems; Polycyclic Compounds; Schisandra; Sesquiterpenes; Structure-Activity Relationship; Tribolium; Triterpenes

2020
Schizandrol A reverses multidrug resistance in resistant chronic myeloid leukemia cells K562/A02.
    Cellular and molecular biology (Noisy-le-Grand, France), 2019, Jan-31, Volume: 65, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Cyclooctanes; Doxorubicin; Drug Resistance, Neoplasm; Humans; Intracellular Space; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lignans; Phosphorylation; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Rhodamine 123

2019
Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3.
    Journal of biochemical and molecular toxicology, 2019, Volume: 33, Issue:5

    Topics: Apoptosis; Cell Survival; Cyclooctanes; Cytokines; Down-Regulation; Humans; Lignans; Lipopolysaccharides; MAP Kinase Kinase 4; Myoblasts, Cardiac; NF-kappa B; Polycyclic Compounds; Schisandra; Signal Transduction; Smad3 Protein

2019
Pharmacokinetics and liver uptake of three Schisandra lignans in rats after oral administration of liposome encapsulating β-cyclodextrin inclusion compound of Schisandra extract.
    Journal of liposome research, 2019, Volume: 29, Issue:2

    Topics: Administration, Oral; Animals; beta-Cyclodextrins; Biological Availability; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Compounding; Lignans; Liposomes; Liver; Particle Size; Plant Extracts; Polycyclic Compounds; Rats, Wistar; Schisandra

2019
An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling.
    Journal of chromatography. A, 2019, Aug-02, Volume: 1598

    Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lignans; Medicine, Chinese Traditional; Plants, Medicinal; Polycyclic Compounds; Quality Control; Rats; Schisandra; Tandem Mass Spectrometry

2019
Combination of schisandrin and nootkatone exerts neuroprotective effect in Alzheimer's disease mice model.
    Metabolic brain disease, 2019, Volume: 34, Issue:6

    Topics: Alzheimer Disease; Animals; Cyclooctanes; Disease Models, Animal; Glutathione; Lignans; Malondialdehyde; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Polycyclic Compounds; Polycyclic Sesquiterpenes; Superoxide Dismutase

2019
Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway.
    Molecules (Basel, Switzerland), 2019, Oct-08, Volume: 24, Issue:19

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cyclooctanes; Disease Models, Animal; Glucose; Lignans; Mice; Models, Biological; Molecular Structure; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxygen; Polycyclic Compounds; Rats; Reperfusion Injury; Signal Transduction; Stroke; TOR Serine-Threonine Kinases

2019
Assaying
    Molecules (Basel, Switzerland), 2020, Jan-11, Volume: 25, Issue:2

    Topics: Azithromycin; Biological Assay; Chlamydophila pneumoniae; Cyclooctanes; Glutathione; Humans; Kinetics; Lignans; Macrophages; Oxidation-Reduction; Phenotype; Polycyclic Compounds; Reactive Oxygen Species; THP-1 Cells

2020
Schizandrin attenuates inflammation induced by avian pathogenic Escherichia coli in chicken type II pneumocytes.
    International immunopharmacology, 2020, Volume: 81

    Topics: Alveolar Epithelial Cells; Animals; Anti-Inflammatory Agents; Bacterial Adhesion; Cells, Cultured; Chickens; Cyclooctanes; Cytokines; Escherichia coli; Escherichia coli Infections; Extracellular Signal-Regulated MAP Kinases; Inflammation; Inflammation Mediators; L-Lactate Dehydrogenase; Lignans; NF-kappa B; Polycyclic Compounds; Poultry Diseases; Signal Transduction

2020
Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies.
    Acta pharmacologica Sinica, 2020, Volume: 41, Issue:8

    Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cyclooctanes; Enzymes; Lignans; Male; Metabolomics; Mice, Inbred ICR; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Polycyclic Compounds; Protein Interaction Maps; Rats; Signal Transduction

2020
Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via the PI3K/AKT pathway.
    Food & function, 2020, Mar-26, Volume: 11, Issue:3

    Topics: Alzheimer Disease; Animals; Apoptosis; Autophagy; Cyclooctanes; Disease Models, Animal; Drug Synergism; Inflammation; Lignans; Mice; Neuroprotective Agents; PC12 Cells; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Polycyclic Sesquiterpenes; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; tau Proteins

2020
Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats.
    Experimental animals, 2020, Aug-05, Volume: 69, Issue:3

    Topics: Alzheimer Disease; Animals; Cognition; Cognitive Dysfunction; Cyclooctanes; Disease Models, Animal; Endoplasmic Reticulum Stress; Lignans; Male; Phytotherapy; Polycyclic Compounds; Rats, Wistar; Schisandra; Sirtuin 1; Streptozocin; Up-Regulation

2020
Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 127

    Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Epithelium, Corneal; Female; Humans; Lignans; Mice; Plant Extracts; Polycyclic Compounds

2020
Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2020, Volume: 37, Issue:9

    Topics: Benzopyrans; Butyrates; Chromatography, Liquid; Coumarins; Cyclooctanes; Dioxoles; Flavanones; Food Analysis; Fruit; Glucosides; Glycosides; Glycyrrhizic Acid; Herbal Medicine; Iridoids; Isoflavones; Lignans; Plant Roots; Plants, Medicinal; Polycyclic Compounds; Tandem Mass Spectrometry

2020
Effect of roasting temperature and time on volatile compounds, total polyphenols, total flavonoids, and lignan of omija (Schisandra chinensis Baillon) fruit extract.
    Food chemistry, 2021, Feb-15, Volume: 338

    Topics: Cooking; Cyclooctanes; Dioxoles; Flavonoids; Fruit; Lignans; Plant Extracts; Polycyclic Compounds; Polyphenols; Schisandra; Temperature; Volatile Organic Compounds

2021
Mechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury.
    Journal of ethnopharmacology, 2021, Jan-10, Volume: 264

    Topics: Animals; Cell Line; Cell Survival; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Inflammation Mediators; Lignans; Male; Mice; Mice, Inbred ICR; Myocardial Reperfusion Injury; Myocytes, Cardiac; Polycyclic Compounds; Rats; Spirostans; Treatment Outcome

2021
Antidepressant-like effects of Schisandrin on lipopolysaccharide-induced mice : Gut microbiota, short chain fatty acid and TLR4/NF-κB signaling pathway.
    International immunopharmacology, 2020, Volume: 89, Issue:Pt A

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Bacteria; Behavior, Animal; Cyclooctanes; Cytokines; Depression; Disease Models, Animal; Dysbiosis; Fatty Acids, Volatile; Gastrointestinal Microbiome; Hippocampus; Host-Pathogen Interactions; Inflammation Mediators; Lignans; Lipopolysaccharides; Male; Mice, Inbred C57BL; Motor Activity; NF-kappa B; Polycyclic Compounds; Signal Transduction; Toll-Like Receptor 4

2020
Impact of volatile oils from processed products of Schisandra chinensis fruits on a mouse model of allergic asthma.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:4

    Topics: Animals; Asthma; Cyclooctanes; Fruit; Hypersensitivity; Lignans; Male; Mice; Oils, Volatile; Ovalbumin; Plant Extracts; Polycyclic Compounds; Schisandra

2020
Schisandrin Restores the Amyloid β-Induced Impairments on Mitochondrial Function, Energy Metabolism, Biogenesis, and Dynamics in Rat Primary Hippocampal Neurons.
    Pharmacology, 2021, Volume: 106, Issue:5-6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Cyclooctanes; Cytochromes c; Energy Metabolism; Hippocampus; Lignans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Models, Biological; Neurons; Neuroprotective Agents; Organelle Biogenesis; Peptide Fragments; Polycyclic Compounds; Primary Cell Culture; Rats, Sprague-Dawley

2021
Pharmacokinetic study of Ninjin'yoeito: Absorption and brain distribution of Ninjin'yoeito ingredients in mice.
    Journal of ethnopharmacology, 2021, Oct-28, Volume: 279

    Topics: Administration, Oral; Animals; Brain; Chromatography, Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Tissue Distribution

2021
Schisandrin improves lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response in vivo and in vitro.
    Journal of food biochemistry, 2022, Volume: 46, Issue:7

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cyclooctanes; Lignans; Lipopolysaccharides; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Polycyclic Compounds; Sepsis

2022
Examination of the Impact of CYP3A4/5 on Drug-Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.
    International journal of molecular sciences, 2022, Apr-19, Volume: 23, Issue:9

    Topics: Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dioxoles; Drug Interactions; Humans; Immunosuppressive Agents; Lignans; Models, Biological; Polycyclic Compounds; Tacrolimus

2022
A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106

    Topics: Animals; Biomarkers; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds; Rats; Schisandra

2022
Schisandra B, a representative lignan from Schisandra chinensis, improves cisplatin-induced toxicity: An in vitro study.
    Phytotherapy research : PTR, 2023, Volume: 37, Issue:2

    Topics: Animals; Cisplatin; Glutathione; Inflammation; Lignans; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rats; Schisandra

2023
Anti-adiposity and lipid-lowering effects of schisandrol A in diet-induced obese mice.
    Journal of food biochemistry, 2022, Volume: 46, Issue:12

    Topics: Animals; Diet, High-Fat; Lignans; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; RNA, Messenger

2022
Bioactive compounds from Schisandra chinensis - Risk for aquatic plants?
    Aquatic toxicology (Amsterdam, Netherlands), 2023, Volume: 254

    Topics: Ecosystem; Humans; Lignans; Schisandra; Water; Water Pollutants, Chemical

2023
Dimethylbutyrylated Dibenzocyclooctadiene Lignans from the Fruits of Schisandra cauliflora Inhibit NO Production in LPS-Activated RAW264.7 Cells.
    Chemistry & biodiversity, 2023, Volume: 20, Issue:6

    Topics: Cyclooctanes; Fruit; Lignans; Lipopolysaccharides; Molecular Structure; Schisandra

2023
Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation.
    Journal of natural medicines, 2023, Volume: 77, Issue:4

    Topics: Cell Proliferation; Lignans; Muscle, Skeletal; Plant Leaves; Schisandra

2023
Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis.
    Scientific reports, 2023, 08-18, Volume: 13, Issue:1

    Topics: Animals; Collagen; Lignans; Mice; Polycyclic Compounds; Pulmonary Fibrosis

2023
Effects of schisandra lignans on the absorption of protopanaxadiol-type ginsenosides mediated by P-glycoprotein and protopanaxatriol-type ginsenosides mediated by CYP3A4.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt B

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Ginsenosides; Lignans; Molecular Docking Simulation; Plant Extracts; Schisandra

2024
Analysis of Volatile Components in Dried Fruits and Branch Exudates of
    Molecules (Basel, Switzerland), 2023, Sep-29, Volume: 28, Issue:19

    Topics: Fruit; Lignans; Plant Extracts; Schisandra

2023