schizandrin a has been researched along with lignans in 130 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.54) | 18.7374 |
| 1990's | 4 (3.08) | 18.2507 |
| 2000's | 16 (12.31) | 29.6817 |
| 2010's | 85 (65.38) | 24.3611 |
| 2020's | 23 (17.69) | 2.80 |
| Authors | Studies |
|---|---|
| Li, XJ; Lin, TJ; Liu, GT; Xin, WJ; Zhao, BL | 1 |
| Cong, PZ; Zhai, HB | 1 |
| Liu, GT | 1 |
| Lesca, P; Liu, KT | 1 |
| Che, CT; Ip, SP; Ko, KM; Ma, CY | 1 |
| Ko, KM; Yim, TK | 1 |
| Yang, SB | 1 |
| Chen, H; Wu, XF; Zhao, ZR | 1 |
| Kim, SH; Kim, SR; Kim, YC; Koo, KA; Lee, MK; Lee, NG; Markelonis, GJ; Oh, TH; Sung, SH; Yang, JH | 1 |
| Burgos, RA; Folch, H; Hancke, JL; Hermosilla, R; Hidalgo, MA; Matthei, SM | 1 |
| Li, JQ; Li, P; Mu, J; Zhang, LQ; Zhu, XL | 1 |
| Huang, T; Shen, P; Shen, Y | 1 |
| Anjia, C; Cunhong, L; Wenhua, G; Xingguo, C; Zhide, H | 1 |
| Hu, X; Lu, Q; Pan, Q; Zhang, K | 1 |
| Kim, DH; Lee, M; Lee, MW; Lim, SY; Shin, J; Yoo, HH | 1 |
| Bi, K; Chen, X; Deng, X; Qiao, L; Shen, Z; Yin, R | 1 |
| Huang, M; Jin, J; Liu, GT; Sun, H | 1 |
| Fu, M; He, XP; Sun, ZH; Xie, ZP; Zong, M; Zuo, HC | 1 |
| Caichompoo, W; Gao, HJ; Hou, TT; Qin, LP; Zhang, QY; Zhou, XJ | 1 |
| Huang, X; Liu, SY; Liu, ZQ; Song, FR | 1 |
| Jiang, W; Kong, L; Wang, X | 1 |
| Liu, C; Wu, H; Zhang, S | 1 |
| Gao, Q; Li, X; Luo, H; Weng, W; Xiao, F | 1 |
| Hu, Y; Sun, R; Yu, J; Zhou, J | 1 |
| Li, WL; Su, MW; Xin, HW; Xiong, L | 1 |
| Chen, DL; Chen, QH; Liang, XX; Liu, GT; Sun, H; Wang, FP | 1 |
| Gu, BH; Kim, DK; Lee, KS; Lee, SH; Lee, YM; Lim, SW; Minh, NV | 1 |
| Chai, Y; Lv, L; Mao, S; Zhang, G; Zhang, H; Zhao, L; Zhu, Z | 1 |
| Cai, BC; Chen, XM; Di, LQ; Han, L; Li, JS; Li, W; Liu, XH | 1 |
| Liu, TT; Ma, CH; Wang, SY; Yang, L; Zhang, RR; Zu, YG | 1 |
| Chen, Q; Cheng, NN; Li, YL; Wang, YM; Wu, YJ | 1 |
| Guan, M; Li, T; Liu, Y; Sheng, Y; Wang, Y; Yuan, G | 1 |
| Li, WL; Su, MW; Xin, HW | 1 |
| Chang, R; Li, X; Wang, Y; Yang, X; Zhang, X | 1 |
| Liu, TT; Ma, CH; Yang, FJ; Yang, L; Zhang, L; Zhang, ZH; Zhao, CJ; Zu, YG | 1 |
| Xiao, Y; Zhang, H | 1 |
| Aves, SJ; Galloway, WR; Laraia, L; Pike, KG; Spring, DR; Wu, W; Zheng, S | 1 |
| Ma, CH; Yang, FJ; Yang, L; Zhang, Y; Zhao, CJ; Zu, YG | 1 |
| Han, N; Hu, D; Li, C; Liu, Z; Miao, L; Wang, D; Wang, H; Yin, J | 1 |
| Ding, Z; Hu, X; Liu, K; Liu, Z; Zhang, B | 1 |
| Dong, JP; He, FC; Li, SX; Liu, WZ; Su, RQ; Zhao, ZQ | 1 |
| Han, Y; Sun, H; Wang, X; Wei, W; Wu, F; Zhang, A | 1 |
| Cao, YF; Fan, XR; Fang, ZZ; Hu, CM; Huang, T; Liu, C; Mo, H; Sun, XY; Zeng, J; Zhang, YY | 1 |
| Han, J; Huang, Y; Jin, S; Li, X; Lv, Q; Pei, J; Yuan, H | 1 |
| Chen, H; Huang, ZJ; Lu, TL; Mao, CQ; Song, Y; Sun, Y; Wu, XY; Xu, B; Zhou, Y | 1 |
| Ekiert, H; Szopa, A | 1 |
| Chang, R; Dou, L; Li, X; Li, Y; Wang, Y; Yang, X; Yue, Y; Zhang, W | 1 |
| Liu, X; Ma, W; Zhang, S | 1 |
| Chen, H; Hu, JP; Li, Y; Sheng, L; Wang, BL | 1 |
| Cao, Y; Ge, G; Hong, JY; Liu, Y; Wu, J; Yang, L; Zhang, Y; Zhu, L | 1 |
| Bi, HC; Chen, X; Huang, M; Li, JL; Qin, XL; Wang, CX; Wang, XD; Wang, Y; Xue, XP; Yang, H; Zhong, GP | 1 |
| Dai, G; Ji, D; Li, L; Lu, T; Mao, C; Sun, Y; Wu, X; Xu, B; Yin, F; Zhou, Y | 1 |
| Li, S; Liu, M; Liu, T; Tu, P; Wang, C; Wang, H; Wang, Y; Wang, Z; Zhao, S | 1 |
| Hu, XL; Liu, ZQ; Pi, ZF; Song, FR; Yu, XL | 1 |
| Han, L; Qu, J; Qu, Q; Wu, LX; Zhan, M; Zhang, W; Zhang, YW; Zhou, HH | 1 |
| Hu, HH; Jiang, HD; Kong, LM; Xu, SY; Yu, LS; Zeng, S; Zhou, H | 1 |
| Cai, H; Che, GY; Cong, YL; Jin, B; Li, ZY; Liu, Y; Si, L; Sun, YX; Tang, B; Wang, AB; Wang, CF; Zhang, XM | 1 |
| Ding, F; Li, GC; Li, JL; Liang, XM; Shi, YW; Wang, CP; Wang, ZW; Zhang, XC | 1 |
| Liang, ZQ; Lu, Y; Song, YZ; Wang, WJ | 1 |
| Carrara, M; Casarin, E; Dall'Acqua, S; Innocenti, G; Slapetová, T; Smejkal, K | 1 |
| Cheng, Q; Ji, B; Liu, J; Wang, O; Wang, Y; Zhao, L; Zhou, F | 1 |
| Adámková, L; Carnecká, M; Humpa, O; Páchniková, G; Porubová Koubíková, L; Slanina, J; Slaninová, I; Smejkal, K | 1 |
| Corona, A; Del Vecchio, C; Esposito, F; Grandi, N; Mandas, D; Parolin, C; Piano, D; Tramontano, E; Xu, L | 1 |
| Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H | 1 |
| Liu, CH; Liu, S; Tao, YY; Yang, T; Zheng, TH | 1 |
| Cai, Q; Du, SS; Zheng, LS | 1 |
| Elofsson, M; Hakala, E; Hanski, L; Uvell, H; Vuorela, H; Vuorela, PM; Yrjönen, T | 1 |
| Deng, S; Guo, CX; Liu, ZQ; Yin, JY; Zhang, W; Zhou, HH | 1 |
| Gao, W; Hou, W; Liu, Q; Wang, D; Wang, Y; Zheng, S | 1 |
| Ekiert, H; Kisiel, W; Szewczyk, A; Szopa, A | 1 |
| An, LB; Cui, L; Dong, PP; Fang, ZZ; Gonzalez, FJ; Li, WT; Song, JH; Sun, XY; Wang, LX; Wu, X; Zhang, YY; Zhao, DW | 1 |
| Liao, L; Song, F; Tu, P; Wang, X; Yu, Q; Zeng, K | 1 |
| Chan, WM; Chen, J; Ko, KM; Leong, PK; Leung, HY; Wong, HS | 1 |
| Duan, MH; Gao, Q; Su, X; Xu, DY; Yan, YL; Yang, Y; Zhang, WF | 1 |
| Feng, X; Gao, C; Liu, L; Qu, D; Shi, F; Su, X; Wang, C | 1 |
| Chen, YH; Hsu, YC; Lee, JC; Lin, CK; Tseng, CK; Wu, YH; Yu, JS | 1 |
| Bradbury, EJ; Brown, CF; Lyles, JT; Nelson, K; Pierce, ST; Quave, CL; Tyler, P | 1 |
| Liu, X; Liu, Y; Wang, Y; Zhang, D; Zhang, W | 1 |
| Geng, Y; Guo, F; Li, S; Wang, S; Wei, J; Wu, H; Yang, H; Yu, Y; Zhang, M | 1 |
| An, F; Guo, M; Hong, M; Lu, Y; Wei, X | 1 |
| Bu, F; Cai, W; Jiao, Z; Li, L; Lin, HS; Ma, G; Shin, JG; Xiang, X; Zhang, H; Zhuang, X | 1 |
| An, F; Guo, M; Hong, M; Lu, Y; Wei, X; Yu, H | 1 |
| Cha, HJ; Chang, YC; Choi, EO; Choi, YH; Hwang, HJ; Kim, BW; Kim, GY; Kim, WJ; Kwon, DH; Leem, SH; Moon, SK; Yun, SJ | 1 |
| Jiang, QC; Wang, SR; Zhang, ZL | 1 |
| Chu, X; Kong, D; Wang, J; Zhang, D | 1 |
| Ahn, JH; Choi, JH; Jang, DS; Lee, K; Lee, KT | 1 |
| Chen, L; Hu, Q; Huang, S; Lu, Y; Xia, C; Xiong, Y; Zhang, H | 1 |
| Granchi, C; Minutolo, F | 1 |
| Bi, HC; Chen, X; Duan, WH; Huang, M; Qin, XL; Wang, HF; Wang, Y | 1 |
| Bai, ZF; Cai, GM; Cui, HR; He, JJ; Li, PY; Li, YM; Niu, M; Sang, XX; Wang, JB; Wang, RL; Xiao, XH | 1 |
| Feng, YL; Li, W; Liu, KY; Liu, YL; Song, YG; Su, D; Yang, LJ | 1 |
| Cheng, X; Ding, XY; Ji, JD; Lu, TL; Mao, CQ; Su, LL; Wang, LJ; Zhang, J | 1 |
| Choi, YH | 1 |
| Li, D; Liu, X; Wang, S; Wang, Z; Wu, Z; Zheng, Q | 1 |
| Jiang, C; Li, S; Liu, M; Xie, R | 1 |
| Du, Z; Fu, Q; Hu, CM; Hu, RX; Yang, K; Zhang, X | 1 |
| Cao, JQ; Deng, ZW; Du, SS; Geng, ZF; Guo, SS; Liang, JY; Pang, X; Wang, Y | 1 |
| Chen, AC; Chen, WC; Lu, CK; Ueng, YF; Wang, HJ | 1 |
| Jeong, MJ; Jung, UJ; Kim, SR | 1 |
| Ding, Q; Li, X; Sun, Y; Zhang, X | 1 |
| He, Y; Hu, M; Li, S; Liu, T; Liu, Y; Liu, Z; Pi, Z; Song, F; Wei, M; Yue, K | 1 |
| Feng, W; Xian, H; Zhang, J | 1 |
| Bi, K; Gao, H; Li, Q; Liu, H; Liu, R; Lv, X; Xu, H; Zhang, M; Zhang, Q; Zhang, Y | 1 |
| Guo, G; Liang, G; Liu, Z; Rajamanicham, V; Wang, Y; Xu, S; Xu, X; Yan, T; Zhou, H | 1 |
| Chen, L; Fan, J; Li, M; Lu, X; Zhu, L | 1 |
| Jin, Y; Liu, F; Pan, L; Zhang, A; Zhi, Y | 1 |
| Bi, Y; Cai, X; Chen, X; Fu, Y; Wang, S | 1 |
| Cao, Y; Cheng, J; Fu, S; Gong, Q; Guo, W; Kan, X; Li, Y; Liu, J; Ma, H; Wang, J; Xu, D | 1 |
| Amiri, KMA; Co, VA; El-Nezami, H; Turner, PC; Wan, MLY; Wang, MF | 1 |
| Duan, J; Guo, S; Ma, X; Zhu, Z | 1 |
| Cai, NN; Jiang, Y; Wang, ZZ; Yang, R; Zhang, XM; Zhu, WQ; Zhu, XC | 1 |
| Ji, L; Ma, L | 1 |
| Cui, L; Cui, Z; Song, X; Xiang, L; Xu, C; Yang, Z; Zhu, W | 1 |
| Chen, BC; Dai, QQ; Dong, QJ; Tu, SL; Wan, ZA; Zheng, BA | 1 |
| Ai, X; Dong, J; Han, G; Liu, Y; Song, J; Wang, Z; Yang, Q; Zhong, L | 1 |
| Choi, H; Jun, HS; Yeon, M | 1 |
| Guo, M; Yan, H | 1 |
| Ghorbani, F; Li, D; Liu, Z; Ni, S; Qian, Z; Yu, B; Yuan, Y; Zhang, F; Zhang, X; Zhang, Z; Zhong, Z | 1 |
| Bao, J; Gong, X; Liu, L; Shi, W; Wang, X; Zhang, L; Zhang, Y | 1 |
| Ge, X; Gong, M; Pu, H; Qian, Q; Wang, F | 1 |
| Chen, L; Huang, XY; Liu, X; Liu, Z; Ren, LQ; Tu, H | 1 |
| Chang, Y; Gao, L; Li, S; Li, T; Song, Z; Yuan, L | 1 |
| Cai, NN; Geng, Q; Jiang, Y; Tang, B; Xiao, YF; Yang, R; Zhang, BY; Zhang, XM; Zhu, WQ | 1 |
| Cai, E; Gouda, M; Lorenzo, JM; Munekata, PES; Wang, R; Wu, Y; Xu, W; Zong, W | 1 |
| Deng, Y; Feng, L; Hong, Y; Su, Y; Xu, D; Zhang, Z | 1 |
| Fu, K; Gong, L; Li, Y; Ma, C; Wang, C; Zhang, Y; Zhou, H | 1 |
| Chi, B; Guo, Y; Sun, Y; Zhao, J | 1 |
| Bi, K; Li, Q; Li, S; Xu, H; Yang, P; Zhang, Q; Zhang, Y | 1 |
| Feng, MF; Hou, HM; Li, PW; Piao, XM; Wang, LB; You, LJ; Zhang, WW; Zhang, Y; Zhao, WP | 1 |
| Deng, L; He, J; Huang, F; Lin, Q; Liu, K; Luo, L; Qiu, Q; Su, J; Zhang, W | 1 |
2 review(s) available for schizandrin a and lignans
| Article | Year |
|---|---|
Activators of Sirtuin-1 and their Involvement in Cardioprotection.
Topics: Benzimidazoles; Cardiotonic Agents; Cardiovascular Diseases; Cyclooctanes; Ginsenosides; Heterocyclic Compounds, 4 or More Rings; Humans; Lignans; Polycyclic Compounds; Resveratrol; Sirtuin 1 | 2018 |
A review: Pharmacology and pharmacokinetics of Schisandrin A.
Topics: Cyclooctanes; Drugs, Chinese Herbal; Lignans; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Schisandra | 2022 |
1 trial(s) available for schizandrin a and lignans
| Article | Year |
|---|---|
Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclooctanes; Epithelial-Mesenchymal Transition; Female; Humans; Lignans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Polycyclic Compounds; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2012 |
127 other study(ies) available for schizandrin a and lignans
| Article | Year |
|---|---|
Detection of free radical scavenging activity of schisanhenol by electron spin resonance.
Topics: Cyclooctanes; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Humans; Lignans; Neutrophils; Oxygen; Polycyclic Compounds | 1990 |
[Mass spectrometric studies on dibenzocyclooctadiene lignan compounds from Schisandraceae plants].
Topics: Chemical Phenomena; Chemistry; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Mass Spectrometry; Polycyclic Compounds | 1990 |
Pharmacological actions and clinical use of fructus schizandrae.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Drugs, Chinese Herbal; Hepatitis B; Humans; Lignans; Lipid Peroxidation; Mice; Microsomes, Liver; Polycyclic Compounds; Rats | 1989 |
Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; In Vitro Techniques; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Microsomes, Liver; Mutagens; NADP; Oxidation-Reduction; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1982 |
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooctanes; Drugs, Chinese Herbal; Female; Glutathione; Lignans; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Polycyclic Compounds; Structure-Activity Relationship | 1997 |
Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Antioxidants; Cyclooctanes; Drugs, Chinese Herbal; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heart; In Vitro Techniques; L-Lactate Dehydrogenase; Lignans; Male; Molecular Conformation; Molecular Structure; Myocardial Reperfusion Injury; Myocardium; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 1999 |
[Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera].
Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Cyclooctanes; Fruit; Lignans; Plants, Medicinal; Polycyclic Compounds; Schisandra | 2001 |
[Determination of schisandrin in shengmaiyin by HPLC].
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Combinations; Drugs, Chinese Herbal; Lignans; Plants, Medicinal; Polycyclic Compounds; Schisandra | 2003 |
Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Glutamic Acid; Intracellular Fluid; Lignans; Neurons; Neuroprotective Agents; Neurotoxins; Peroxides; Phytotherapy; Plant Extracts; Polycyclic Compounds; Rats; Schisandra | 2004 |
Determination of specific receptor sites for platelet activating factor in bovine neutrophils.
Topics: Animals; Azepines; Base Sequence; Blotting, Western; Cattle; Cyclooctanes; Diterpenes; DNA Primers; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Ginkgolides; HL-60 Cells; Humans; Kinetics; Lactones; Lignans; Molecular Sequence Data; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polycyclic Compounds; Radioligand Assay; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Triazoles; Tritium | 2004 |
[Study on the simultaneous spectrophotometric determination of three components including deoxyschizandrin by ridge regression method].
Topics: Cyclooctanes; Lignans; Polycyclic Compounds; Regression Analysis; Spectrophotometry | 2004 |
Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography.
Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Cyclooctanes; Fruit; Lignans; Polycyclic Compounds; Schisandra; Solvents | 2005 |
Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis.
Topics: Cyclooctanes; Drugs, Chinese Herbal; Electrophoresis, Capillary; Lignans; Polycyclic Compounds; Reproducibility of Results; Schisandra; Seeds; Temperature | 2005 |
Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Daunorubicin; Dioxoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; Paclitaxel; Polycyclic Compounds; Prohibitins; Vincristine | 2006 |
Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cyclooctanes; Digoxin; Humans; Lignans; Polycyclic Compounds; Rhodamine 123; Schisandra | 2007 |
Determination of deoxyschizandrin in rat plasma by LC-MS.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cyclooctanes; Dose-Response Relationship, Drug; Lignans; Male; Mass Spectrometry; Medicine, Chinese Traditional; Metabolic Clearance Rate; Molecular Structure; Plant Extracts; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Regression Analysis; Reproducibility of Results; Schisandra; Time Factors | 2008 |
Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclooctanes; Dioxoles; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fruit; Genes, MDR; Humans; Lignans; Mice; Mice, Nude; Neoplasm Proteins; Phytotherapy; Plant Preparations; Polycyclic Compounds; Protein Kinase C; Schisandra; Xenograft Model Antitumor Assays | 2008 |
Deoxyschisandrin modulates synchronized Ca2+ oscillations and spontaneous synaptic transmission of cultured hippocampal neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Cyclooctanes; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Lignans; Neurons; Polycyclic Compounds; Rats; Schisandra; Sodium Channel Blockers; Sodium Channels; Synaptic Transmission | 2008 |
Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.
Topics: Alkaline Phosphatase; Animals; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Cyclooctanes; Enzyme Activators; Lignans; Osteoblasts; Plant Extracts; Polycyclic Compounds; Rats; Schisandra | 2009 |
[Lignans from different processed products of Schisandra chinensis fruits].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drug Compounding; Drugs, Chinese Herbal; Fruit; Hot Temperature; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra; Spectrometry, Mass, Electrospray Ionization | 2008 |
The effect of deoxyschisandrin on blood tacrolimus levels: a case report.
Topics: Adult; Cyclooctanes; Drug Interactions; Humans; Immunosuppressive Agents; Lignans; Liver Transplantation; Living Donors; Male; Polycyclic Compounds; Tacrolimus | 2010 |
Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract.
Topics: Antioxidants; Chemical Fractionation; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Plant Extracts; Polycyclic Compounds; Pressure; Schisandra | 2009 |
[Research on liposoluble ingredients of Quchiling].
Topics: Allylbenzene Derivatives; Animals; Anisoles; Brain; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Gas Chromatography-Mass Spectrometry; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2010 |
[Changes of lignans' content in stems of Schisandra chinensis].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Plant Stems; Polycyclic Compounds; Schisandra | 2009 |
Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inhibitory Concentration 50; Lignans; Male; Microsomes, Liver; Midazolam; Polycyclic Compounds; Rats; Rats, Wistar; Time Factors | 2010 |
Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A.
Topics: Cyclooctanes; Drug Resistance, Multiple; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Rhodamine 123; Schisandra; Structure-Activity Relationship | 2010 |
Deoxyschisandrin inhibits H2O2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB.
Topics: Animals; Apoptosis; Cyclooctanes; Epithelial Cells; Humans; Hydrogen Peroxide; Intestinal Mucosa; Lignans; NF-kappa B; Oxidants; Oxidative Stress; Polycyclic Compounds | 2010 |
Rapid determination and pharmacokinetics study of lignans in rat plasma after oral administration of Schisandra chinensis extract and pure deoxyschisandrin.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Cyclooctanes; Drug Stability; Drugs, Chinese Herbal; Lignans; Linear Models; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schisandra; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
[Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Cyclooctanes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Duodenum; Fruit; Ileum; Intestinal Absorption; Jejunum; Lignans; Male; Perfusion; Permeability; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra | 2010 |
Study on ionic liquid-based ultrasonic-assisted extraction of biphenyl cyclooctene lignans from the fruit of Schisandra chinensis Baill.
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Fruit; Ionic Liquids; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Solid Phase Extraction; Time Factors; Ultrasonics | 2011 |
[Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
Topics: Animals; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hepatocytes; Inhibitory Concentration 50; Lignans; Male; Microsomes, Liver; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schisandra | 2010 |
Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds | 2011 |
Inhibitory effects of continuous ingestion of Schisandrin A on CYP3A in the rat.
Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Ketoconazole; Lignans; Male; Microsomes, Liver; Midazolam; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2012 |
Screening vasoconstriction inhibitors from traditional Chinese medicines using a vascular smooth muscle/cell membrane chromatography-offline-liquid chromatography-mass spectrometry.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; In Vitro Techniques; Lignans; Male; Membranes, Artificial; Muscle Contraction; Muscle, Smooth, Vascular; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation.
Topics: Adsorption; Analysis of Variance; Chromatography, Ion Exchange; Cyclooctanes; Dioxoles; Ethanol; Fruit; Hydrolysis; Ion Exchange Resins; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Temperature | 2011 |
Homogeneous ionic liquid microextraction of the active constituents from fruits of Schisandra chinensis and Schisandra sphenanthera.
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Imidazoles; Ionic Liquids; Lignans; Polycyclic Compounds; Schisandra | 2012 |
A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Drug Screening Assays, Antitumor; Humans; Lignans; Molecular Structure; Polycyclic Compounds | 2012 |
Enrichment and purification of deoxyschizandrin and γ-schizandrin from the extract of Schisandra chinensis fruit by macroporous resins.
Topics: Adsorption; Cyclooctanes; Fruit; Lignans; Polycyclic Compounds; Resins, Synthetic; Schisandra | 2012 |
Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ₁₋₄₂-induced memory impairment in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cerebral Cortex; Cyclooctanes; Drugs, Chinese Herbal; Fruit; Glutathione; Glutathione Peroxidase; Hippocampus; Lignans; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Polycyclic Compounds; Schisandra; Superoxide Dismutase | 2012 |
[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra | 2012 |
Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2013 |
Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction.
Topics: Cyclooctanes; Dioxoles; Glucuronosyltransferase; Herb-Drug Interactions; Lignans; Molecular Structure; Polycyclic Compounds; Protein Isoforms | 2012 |
Schisandra lignans-loaded enteric nanoparticles: preparation, characterization, and in vitro-in vivo evaluation.
Topics: Animals; Biological Availability; Crystallization; Cyclooctanes; Drug Carriers; Drug Compounding; Drug Stability; Lignans; Male; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polycyclic Compounds; Rats; Rats, Wistar; Schisandra; Solubility; Surface Properties; Wettability | 2013 |
Effect of acupuncture on target tissue distribution of Schisandra lignans.
Topics: Acupuncture Therapy; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Polycyclic Compounds; Rats; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Tissue Distribution | 2013 |
Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine).
Topics: Cell Differentiation; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Methanol; Plant Shoots; Polycyclic Compounds; Schisandra; Sonication | 2013 |
Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Apoptosis; Arrhythmias, Cardiac; Cardiotonic Agents; Caspase 3; Cyclooctanes; Cytoprotection; Dioxoles; Disease Models, Animal; Gene Expression Regulation; Hemodynamics; Hydrogen Peroxide; Lignans; Male; Malondialdehyde; Membrane Glycoproteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Polycyclic Compounds; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase | 2013 |
Effects of piperine and deoxyschizandrin on synchronized Ca²⁺ oscillations in cultured hippocampal neuronal cells.
Topics: Alkaloids; Animals; Benzodioxoles; Calcium Channels; Calcium Signaling; Cells, Cultured; Cyclooctanes; Drug Synergism; Hippocampus; Lignans; Models, Biological; Neurons; Piperidines; Polycyclic Compounds; Polyunsaturated Alkamides; Rats | 2013 |
Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Male; Microsomes, Liver; Plants, Medicinal; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2013 |
Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A.
Topics: Animals; Biotransformation; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Kinetics; Lignans; Male; Microsomes, Liver; Midazolam; Nifedipine; Oxidation-Reduction; Polycyclic Compounds; Rats; Rats, Wistar; Testosterone | 2014 |
In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus.
Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tablets; Tacrolimus | 2014 |
Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis).
Topics: Acupuncture Therapy; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Linear Models; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution | 2014 |
Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Male; Metabolic Networks and Pathways; Models, Molecular; Oxidation-Reduction; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method].
Topics: Countercurrent Distribution; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.
Topics: Berberine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coumarins; Cyclooctanes; Cyclopentanes; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Furans; Ginkgolides; Hep G2 Cells; Humans; Isoflavones; Kinetics; Lignans; Luteolin; Phytochemicals; Polycyclic Compounds | 2014 |
Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP2C19; Data Interpretation, Statistical; Enzyme Inhibitors; Fluvoxamine; Humans; Insecta; Lignans; Microsomes, Liver; Omeprazole; Plant Preparations; Polycyclic Compounds; Recombinant Proteins; Sesquiterpenes; Ticlopidine | 2014 |
Schisandrin A and B affect subventricular zone neurogenesis in mouse.
Topics: Animals; Cell Proliferation; Cell Survival; Cyclooctanes; Lateral Ventricles; Lignans; Male; Mice; Neurogenesis; Neurons; Olfactory Bulb; Polycyclic Compounds | 2014 |
Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium; Caspase 3; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cyclooctanes; Glucose; L-Lactate Dehydrogenase; Lignans; MAP Kinase Signaling System; Medicine, Chinese Traditional; Neurons; Neuroprotective Agents; Phytotherapy; Polycyclic Compounds; Rats; Receptor, Anaphylatoxin C5a; Receptors, G-Protein-Coupled; Reperfusion Injury; Schisandra; Signal Transduction | 2014 |
The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy.
Topics: Animals; Autophagy; Chemical and Drug Induced Liver Injury; Cyclooctanes; Galactosamine; Lignans; Male; Mice; Mice, Inbred ICR; Polycyclic Compounds; Random Allocation; Schisandra | 2014 |
Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (-)-gomisin N in human tumour cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooctanes; Fruit; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Schisandra | 2014 |
Hepatoprotective effect of Schisandra chinensis (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Lignans; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred ICR; Plant Extracts; Polycyclic Compounds; Rubus; Schisandra | 2014 |
Identification of key structural characteristics of Schisandra chinensis lignans involved in P-glycoprotein inhibition.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cyclooctanes; Doxorubicin; G2 Phase Cell Cycle Checkpoints; Humans; Lignans; Molecular Structure; Polycyclic Compounds; Quantitative Structure-Activity Relationship; Russia; Schisandra; Seeds | 2014 |
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Resistance, Multiple, Viral; Drugs, Chinese Herbal; Fruit; HIV Reverse Transcriptase; HIV-1; Lignans; Mutation; Polycyclic Compounds; Reverse Transcriptase Inhibitors; Schisandra; Virus Replication | 2015 |
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dioxoles; Lignans; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Polycyclic Compounds; Protective Agents; Schisandra | 2015 |
Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.
Topics: Administration, Oral; Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Kidney; Lignans; Liver; Liver Cirrhosis; Male; Polycyclic Compounds; Rats; Rats, Wistar; Tissue Distribution | 2015 |
[Study on chemical constituents from Schisandra chinensis stem].
Topics: Cyclooctanes; Guaiacol; Lignans; Phytochemicals; Plant Stems; Polycyclic Compounds; Schisandra; Sitosterols | 2014 |
Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis.
Topics: Anti-Bacterial Agents; Bacteria; Cell Line; Chlamydia Infections; Chlamydia trachomatis; Chlamydophila pneumoniae; Cyclooctanes; Humans; Lignans; Microbial Sensitivity Tests; Polycyclic Compounds; Reactive Oxygen Species; Schisandra | 2015 |
Schisandrin A and B induce organic anion transporting polypeptide 1B1 transporter activity.
Topics: Abietanes; Cell Line, Tumor; Cyclooctanes; Estrone; Humans; Lignans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Plants, Medicinal; Polycyclic Compounds; RNA, Messenger | 2015 |
The Protecting Effect of Deoxyschisandrin and Schisandrin B on HaCaT Cells against UVB-Induced Damage.
Topics: Antioxidants; Apoptosis; Caspases; Cell Line; Cell Survival; Cyclooctanes; Cytoprotection; DNA Damage; Humans; Keratinocytes; Lignans; Polycyclic Compounds; Reactive Oxygen Species; Schisandra; Ultraviolet Rays | 2015 |
Isolation of three dibenzocyclooctadiene lignans from in vitro cultures of Schisandra chinensis (Turcz.) Baill.--the first report.
Topics: Cells, Cultured; Chromatography, Thin Layer; Cyclooctanes; Dioxoles; Lignans; Magnetic Resonance Spectroscopy; Plant Leaves; Plant Shoots; Polycyclic Compounds; Schisandra | 2015 |
Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis.
Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glucuronosyltransferase; Herb-Drug Interactions; Lignans; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Structure-Activity Relationship | 2015 |
Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Cyclooctanes; Down-Regulation; Inflammation; Inflammation Mediators; Janus Kinase 2; Lignans; Lipopolysaccharides; Mice; Mice, Inbred ICR; Microglia; Neuroprotection; NF-kappa B; Polycyclic Compounds; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor; TNF Receptor-Associated Factor 6 | 2016 |
Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Concanavalin A; Cyclooctanes; Cytokines; Edema; Enzyme-Linked Immunosorbent Assay; Female; Glutathione; Glutathione Transferase; Inflammation; Lignans; Lipopolysaccharides; Mice; Mice, Inbred ICR; Polycyclic Compounds; RAW 264.7 Cells | 2016 |
Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; CD4-Positive T-Lymphocytes; Cell Line; Colitis, Ulcerative; Cyclooctanes; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation; Inflammation; Lignans; Mice; Mice, Inbred C57BL; Polycyclic Compounds | 2016 |
A microemulsion co-loaded with Schizandrin A-docetaxel enhances esophageal carcinoma treatment through overcoming multidrug resistance.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cyclooctanes; Docetaxel; Dose-Response Relationship, Drug; Drug Combinations; Drug Compounding; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Emulsions; Esophageal Neoplasms; Humans; Inhibitory Concentration 50; Lignans; Mice, Inbred BALB C; Mice, Nude; Particle Size; Polycyclic Compounds; Solubility; Surface Properties; Taxoids; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway.
Topics: Animals; Antiviral Agents; Cell Line; Cell Line, Tumor; Cricetinae; Cricetulus; Cyclooctanes; Dengue; Dengue Virus; Humans; Interferons; Lignans; Mice; Mice, Inbred ICR; Polycyclic Compounds; Signal Transduction; STAT Transcription Factors; Up-Regulation; Virus Replication | 2017 |
Comparative Phytochemical Analysis of Chinese and Bay Starvine (Schisandra spp.): Potential for Development as a New Dietary Supplement Ingredient.
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dietary Supplements; Dioxoles; Fruit; Lignans; Medicine, Chinese Traditional; Phenols; Phytochemicals; Plant Extracts; Polycyclic Compounds; Schisandra; Spectroscopy, Fourier Transform Infrared; Tannins | 2017 |
Study on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats.
Topics: Animals; Caco-2 Cells; Catechin; Cyclooctanes; Female; Humans; Lignans; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tea | 2018 |
Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach.
Topics: Actinin; Animals; Bosentan; Cardiotonic Agents; Cell Differentiation; Cell Line; Cyclooctanes; Drugs, Chinese Herbal; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Intestinal Mucosa; Intestines; Lignans; Male; Medicine, Chinese Traditional; Metabolic Networks and Pathways; Metabolome; Myocytes, Cardiac; Natriuretic Peptide, Brain; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Sulfonamides; Troponin T | 2017 |
Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation.
Topics: Acne Vulgaris; Anti-Inflammatory Agents; Cyclooctanes; Humans; Inflammation; Lignans; MAP Kinase Signaling System; Polycyclic Compounds; Propionibacterium acnes; THP-1 Cells | 2017 |
Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling.
Topics: Area Under Curve; Biotransformation; China; Computational Biology; Computer Simulation; Cyclooctanes; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Expert Systems; Female; Humans; Immunosuppressive Agents; Lignans; Male; Models, Biological; Polycyclic Compounds; Protective Agents; Software; Tacrolimus | 2018 |
Comparative effects of schisandrin A, B, and C on Propionibacterium acnes-induced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis.
Topics: Cell Survival; Cyclooctanes; Humans; Interleukin-1beta; Lignans; NLR Family, Pyrin Domain-Containing 3 Protein; Polycyclic Compounds; Propionibacterium acnes; Pyroptosis; Schisandra; THP-1 Cells | 2017 |
Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling.
Topics: Animals; Cyclooctanes; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Humans; Inflammation; Lignans; Lipopolysaccharides; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; RAW 264.7 Cells; Signal Transduction | 2018 |
Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation.
Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Breast Neoplasms; Cyclooctanes; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lignans; Phosphorylation; Polycyclic Compounds; Signal Transduction; STAT3 Transcription Factor; Transcription Factor RelA; Tumor Cells, Cultured | 2018 |
RETRACTED: Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclooctanes; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Lignans; MicroRNAs; NF-kappa B; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Signal Transduction; Up-Regulation | 2018 |
Deoxyschizandrin, Isolated from Schisandra Berries, Induces Cell Cycle Arrest in Ovarian Cancer Cells and Inhibits the Protumoural Activation of Tumour-Associated Macrophages.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chemokine CCL5; Cyclin E; Cyclooctanes; Female; Fruit; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Lignans; Macrophages; Matrix Metalloproteinase 9; Oncogene Proteins; Ovarian Neoplasms; Polycyclic Compounds; Reactive Oxygen Species; Schisandra; Vascular Endothelial Growth Factor A | 2018 |
Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3.
Topics: Atorvastatin; Cyclooctanes; Drug Interactions; HEK293 Cells; Humans; Kinetics; Lignans; Liver; Liver-Specific Organic Anion Transporter 1; Polycyclic Compounds; Protective Agents; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2019 |
[Determination of hepatic and small intestinal distribution of lignans of Wuzhi tablet in rats by liquid chromatography tandem mass spectrometry method].
Topics: Animals; Chromatography, Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Intestine, Small; Lignans; Liver; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Tablets; Tandem Mass Spectrometry | 2016 |
[Inhibitory effect and mechanism of deoxyschizandrin on NLRP3 inflammasome].
Topics: Caspase 1; Cells, Cultured; Cyclooctanes; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Lignans; Macrophages; NLR Family, Pyrin Domain-Containing 3 Protein; Polycyclic Compounds; Transcription Factor RelA | 2017 |
[Rapid identification of the different constituents in Fructus Schisandrae Chinensis before and after processing by UHPLC-QTOF/MS~E combining with metabonomics].
Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Metabolomics; Polycyclic Compounds; Schisandra | 2016 |
[Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS].
Topics: Acetic Acid; Animals; Bile; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Feces; Lignans; Liver Diseases, Alcoholic; Plasma; Polycyclic Compounds; Rats; Schisandra; Urine | 2016 |
Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cyclooctanes; Cytoprotection; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Hydrogen Peroxide; Lignans; Membrane Potential, Mitochondrial; Mice; Mitochondria, Muscle; Muscle, Skeletal; Oxidative Stress; Polycyclic Compounds; Reactive Oxygen Species; Signal Transduction | 2018 |
Deoxyschizandrin Loaded Liposomes on the Suppression Lipid Accumulation in 3T3-L1 Adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cyclooctanes; Drug Liberation; Lignans; Lipid Droplets; Lipid Metabolism; Liposomes; Liver; Male; Mice; Polycyclic Compounds; Temperature | 2018 |
Schizandrin A Alleviates LPS-Induced Injury in Human Keratinocyte Cell Hacat Through a MicroRNA-127-Dependent Regulation.
Topics: Antagomirs; Apoptosis; Cell Line; Cell Survival; Cyclooctanes; Humans; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; MicroRNAs; p38 Mitogen-Activated Protein Kinases; Polycyclic Compounds; Tumor Necrosis Factor-alpha | 2018 |
Evaluation of the inhibition of human carboxylesterases (CESs) by the active ingredients from
Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; Lignans; Microsomes, Liver; Molecular Docking Simulation; Polycyclic Compounds; Schisandra | 2019 |
Chemical constituents isolated from stems of
Topics: Animals; Cyclooctanes; Dioxoles; Feeding Behavior; Lignans; Plant Stems; Polycyclic Compounds; Schisandra; Sesquiterpenes; Structure-Activity Relationship; Tribolium; Triterpenes | 2020 |
Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation.
Topics: Animals; Cyclooctanes; Cytochrome P-450 CYP3A; Drug Interactions; Drugs, Chinese Herbal; Humans; Lignans; Male; Nifedipine; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2019 |
Schizandrin A supplementation improves nonalcoholic fatty liver disease in mice fed a high-fat and high-cholesterol diet.
Topics: Animals; Antioxidants; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cyclooctanes; Diet, High-Fat; Dietary Fats; Dietary Supplements; Fatty Acids; Fatty Acids, Nonesterified; Feces; Lignans; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phytotherapy; Plant Extracts; Polycyclic Compounds; Schisandra; Triglycerides | 2019 |
Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclooctanes; Gene Expression Regulation, Neoplastic; Humans; Lignans; MAP Kinase Signaling System; MicroRNAs; Polycyclic Compounds; RNA Interference; Thyroid Neoplasms; Wnt Signaling Pathway | 2019 |
Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from
Topics: Alzheimer Disease; Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclooctanes; Lignans; Metabolic Networks and Pathways; Molecular Structure; Neurons; Neurotransmitter Agents; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2019 |
Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooctanes; Drug Synergism; Gefitinib; Humans; I-kappa B Kinase; Lignans; Lung Neoplasms; Molecular Dynamics Simulation; NF-kappa B; Polycyclic Compounds; Protein Conformation; Signal Transduction | 2019 |
An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lignans; Medicine, Chinese Traditional; Plants, Medicinal; Polycyclic Compounds; Quality Control; Rats; Schisandra; Tandem Mass Spectrometry | 2019 |
Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooctanes; Endoplasmic Reticulum Stress; Female; Humans; Lignans; Mice; Polycyclic Compounds; Schisandra; Triple Negative Breast Neoplasms; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2019 |
The Pharmacokinetic Prediction of Cyclosporin A after Coadministration with Wuzhi Capsule.
Topics: Adult; Cyclooctanes; Cyclosporine; Dioxoles; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Immunosuppressive Agents; Lignans; Male; Polycyclic Compounds | 2019 |
Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy.
Topics: Animals; Autophagy; Autophagy-Related Proteins; Behavior, Animal; Cyclooctanes; Disease Models, Animal; Dopaminergic Neurons; Humans; Inflammation Mediators; Lignans; Male; Mice; MPTP Poisoning; Neuroprotective Agents; PC12 Cells; Polycyclic Compounds; Rats; Substantia Nigra | 2019 |
Schizandrin A exerts anti-tumor effects on A375 cells by down-regulating H19.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooctanes; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Lignans; Melanoma; MicroRNAs; Polycyclic Compounds; Real-Time Polymerase Chain Reaction; RNA, Long Noncoding; Signal Transduction | 2019 |
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Cells, Cultured; Cyclooctanes; Epithelial Cells; Female; Interleukin-1beta; Lignans; Lipopolysaccharides; Mammary Glands, Animal; Mastitis; Mice, Inbred C57BL; NF-E2-Related Factor 2; Peroxidase; Polycyclic Compounds; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation.
Topics: Catalase; Cell Cycle Checkpoints; Cell Death; Cell Nucleus; Cell Survival; Cyclooctanes; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Enterocytes; Gene Expression Regulation; Glutathione Peroxidase; Heme Oxygenase-1; HT29 Cells; Humans; Inflammation; Inflammation Mediators; Interleukin-8; Lignans; Lipid Peroxidation; MAP Kinase Signaling System; Models, Biological; NF-E2-Related Factor 2; NF-kappa B; Nitrites; Oxidative Stress; Polycyclic Compounds; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Trichothecenes | 2019 |
The effect of deoxyschizandrin on chronic unpredictable mild stress-induced depression.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cyclooctanes; Depression; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Lignans; Male; Mice; Polycyclic Compounds; Stress, Psychological | 2021 |
Schisandrin A and B enhance the dentate gyrus neurogenesis in mouse hippocampus.
Topics: Animals; Cell Proliferation; Cyclooctanes; Dentate Gyrus; Hippocampus; Lignans; Male; Mice; Neurogenesis; Neurons; Polycyclic Compounds | 2020 |
MEG3 is restored by schisandrin A and represses tumor growth in choriocarcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Choriocarcinoma; Cyclooctanes; Female; Gene Expression Regulation, Neoplastic; Humans; Lignans; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Polycyclic Compounds; Pregnancy; Proto-Oncogene Proteins c-akt; RNA, Long Noncoding; Signal Transduction; Uterine Neoplasms | 2020 |
Evidence of anti-inflammatory activity of Schizandrin A in animal models of acute inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooctanes; Disease Models, Animal; Edema; Inflammation; Inflammation Mediators; Lignans; Male; Mice; NF-kappa B; Polycyclic Compounds; Signal Transduction; Toll-Like Receptor 4; Xylenes | 2020 |
Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; China; Colonic Neoplasms; Colorectal Neoplasms; Cyclooctanes; DNA-Binding Proteins; Heat Shock Transcription Factors; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Lignans; Molecular Docking Simulation; Polycyclic Compounds; Transcription Factors | 2020 |
Effects of 27 natural products on drug metabolism genes in channel catfish (
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Biotransformation; Cell Line; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Ictaluridae; Lignans; Polycyclic Compounds; Pregnane X Receptor | 2020 |
Preventive Effects of Schisandrin A, A Bioactive Component of
Topics: Animals; Cells, Cultured; Cyclooctanes; Dexamethasone; Gene Expression; Lignans; Male; Mice, Inbred C57BL; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Myosin Heavy Chains; Myostatin; Organ Size; Phytotherapy; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Schisandra; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2020 |
Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooctanes; Female; Gene Expression Regulation, Neoplastic; Humans; Lignans; MicroRNAs; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Signal Transduction | 2020 |
Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling.
Topics: Animals; Bone Marrow Cells; Cyclooctanes; Female; Femur; Lignans; Macrophages; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Osteoclasts; Osteogenesis; Polycyclic Compounds; RANK Ligand; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Stem Cells; TNF Receptor-Associated Factor 6; Up-Regulation | 2020 |
Therapeutic effect of Schisandrin A on avian colibacillosis through gut-liver axis.
Topics: Animals; Chickens; Cyclooctanes; Escherichia coli; Escherichia coli Infections; Lignans; Liver; Polycyclic Compounds | 2021 |
Schizandrin A induces the apoptosis and suppresses the proliferation, invasion and migration of gastric cancer cells by activating endoplasmic reticulum stress.
Topics: Apoptosis; Cell Cycle; Cell Movement; Cell Proliferation; Cyclooctanes; Endoplasmic Reticulum Stress; Humans; Lignans; Neoplasm Invasiveness; Polycyclic Compounds; Stomach Neoplasms; Tumor Cells, Cultured; Wound Healing | 2021 |
Bio-informatics and in Vitro Experiments Reveal the Mechanism of Schisandrin A Against MDA-MB-231 cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Computational Biology; Cyclooctanes; Female; Humans; Lignans; Molecular Docking Simulation; Network Pharmacology; Polycyclic Compounds; Protein Interaction Maps; Signal Transduction | 2021 |
Schisandrin A protects against isoproterenol‑induced chronic heart failure via miR‑155.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Cyclooctanes; Echocardiography; Heart Failure; Heart Ventricles; Isoproterenol; Lignans; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left | 2022 |
Schisandrin A and B affect the proliferation and differentiation of neural stem cells.
Topics: Cell Differentiation; Cell Proliferation; Cyclooctanes; Lignans; Neural Stem Cells; Neurogenesis; Polycyclic Compounds | 2022 |
The Antioxidant Phytochemical Schisandrin A Promotes Neural Cell Proliferation and Differentiation after Ischemic Brain Injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Differentiation; Cell Line; Cell Proliferation; Cyclooctanes; Lignans; Male; Mice; Neural Stem Cells; Phytochemicals; Polycyclic Compounds | 2021 |
Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage.
Topics: Apoptosis; Cyclooctanes; Humans; Intestinal Mucosa; Lignans; Mitogen-Activated Protein Kinases; Mycophenolic Acid; Oxidative Stress; Polycyclic Compounds; Tight Junctions | 2022 |
Deoxyschizandrin Inhibits the Proliferation, Migration, and Invasion of Bladder Cancer Cells through ALOX5 Regulating PI3K-AKT Signaling Pathway.
Topics: Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooctanes; Humans; Lignans; Phosphatidylinositol 3-Kinases; Polycyclic Compounds; Proto-Oncogene Proteins c-akt; Signal Transduction; Urinary Bladder Neoplasms | 2022 |
A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties.
Topics: Animals; Biomarkers; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Polycyclic Compounds; Rats; Schisandra | 2022 |
Schisandrin A ameliorates increased pulmonary capillary endothelial permeability accompanied with sepsis through inhibition of RhoA/ROCK1/MLC pathways.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Lignans; Lipopolysaccharides; Lung; Mice; Permeability; Rats; rho-Associated Kinases; Sepsis | 2023 |
Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Inflammation; Lignans; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin | 2023 |