Page last updated: 2024-09-04

schizandrer a and lignans

schizandrer a has been researched along with lignans in 63 studies

Compound Research Comparison

Studies (schizandrer a)	Trials (schizandrer a)	Recent Studies (post-2010) (schizandrer a)	Studies (lignans)	Trials (lignans)	Recent Studies (post-2010) (lignans)
65	0	52	7,024	95	4,172

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.76)	18.7374
1990's	1 (1.59)	18.2507
2000's	6 (9.52)	29.6817
2010's	44 (69.84)	24.3611
2020's	9 (14.29)	2.80

Authors

Authors	Studies
Ikeya, Y; Kobayashi, H; Taguchi, H; Yosioka, I	1
Lesca, P; Liu, KT	2
Chen, CC; Hsu, MF; Raung, SL; Wang, JP	1
Hiratsuka, A; Iwata, H; Kadota, S; Tezuka, Y; Watabe, T	1
Hu, X; Lu, Q; Pan, Q; Zhang, K	1
Chang, YJ; Choi, G; Choi, YB; Do, EU; Kang, TM; Kim, HJ; Kim, SI; Nam, HY; Piao, LZ; Shin, J	1
Huang, X; Liu, SY; Liu, ZQ; Song, FR	1
Gao, XM; He, F; Huang, SX; Lu, Y; Pu, JX; Sun, HD; Wang, RR; Xiao, WL; Zheng, QT; Zheng, YT; Zhong, JL	1
Chen, M; Li, L; Xu, XM	1
Chen, W; Gao, S; Sun, L; Tai, Z; Wei, H; Xu, W	1
Ci, X; Deng, X; Li, H; Li, R; Ren, R; Song, Y; Wang, D; Xu, K; Yu, Q	1
Lin, X; Shaw, PC; Song, JX; Sze, SC; Tong, Y; Wong, RN; Zhang, YB	1
Chai, X; Chen, S; Yu, C; Yu, L; Zeng, S	1
Guan, M; Li, T; Liu, Y; Sheng, Y; Wang, Y; Yuan, G	1
Liu, TT; Ma, CH; Yang, FJ; Yang, L; Zhang, L; Zhang, ZH; Zhao, CJ; Zu, YG	1
Li, D; Li, R; Ye, Z; Zhang, Q; Zhou, D	1
Choi, YW; Kang, JS; Kim, SG; Kim, YH; Lee, SJ; Park, DJ; Park, SY; Ryu, EY; Seetharaman, R	1
Xiao, Y; Zhang, H	1
Dong, JP; He, FC; Li, SX; Liu, WZ; Su, RQ; Zhao, ZQ	1
Han, Y; Sun, H; Wang, X; Wei, W; Wu, F; Zhang, A	1
Cao, YF; Fan, XR; Fang, ZZ; Hu, CM; Huang, T; Liu, C; Mo, H; Sun, XY; Zeng, J; Zhang, YY	1
Bi, K; Chen, X; Fan, R; Geng, L; He, B; Jia, Y; Li, Q; Su, D; Wei, B; Zhao, L	1
Chang, R; Dou, L; Li, X; Li, Y; Wang, Y; Yang, X; Yue, Y; Zhang, W	1
Bi, HC; Chen, X; Huang, M; Li, JL; Qin, XL; Wang, CX; Wang, XD; Wang, Y; Xue, XP; Yang, H; Zhong, GP	1
Bae, YS; Choi, YW; Ko, MJ; Lee, SJ; Park, SY	1
Hu, XL; Liu, ZQ; Pi, ZF; Song, FR; Yu, XL	1
Bi, K; Guo, L; Jia, Y; Li, H; Li, X; Liu, Z; Mao, X; Xu, X; Zhao, X	1
Chen, X; He, Y; Peng, D; Shen, Y; Zhang, Q; Zhou, F	1
Fu, Y; Lei, H; Li, Y; Wei, Z; Xie, G; Yang, Z; Zhang, N; Zhou, E	1
Ci, X; Jie, J; Li, D; Li, Y; Liu, C; Peng, L; Wen, Z	1
Bi, H; Chen, P; Fan, X; Huang, M; Jiang, Y; Tan, H; Wang, Y; Zeng, H	1
Chong, CM; Guo, BJ; Hoi, PM; Lee, SM; Li, S; Sa, F; Zhang, LQ; Zhang, ZJ; Zheng, Y	1
Liu, CH; Liu, S; Tao, YY; Yang, T; Zheng, TH	1
An, LP; Chen, M; Dou, ZH; Ju, YF; Luo, L; Miao, YX; Qiao, J	1
Chan, SW; Chang, RC; Chong, CM; Hoi, PM; Sa, F; Wang, Y; Yuen Lee, SM; Zhang, LQ; Zhou, ZY	1
An, LB; Cui, L; Dong, PP; Fang, ZZ; Gonzalez, FJ; Li, WT; Song, JH; Sun, XY; Wang, LX; Wu, X; Zhang, YY; Zhao, DW	1
Chengqing, L; Chenming, N; Tao, L; Xiaoyang, L	1
Jun, F; Li, D; Liao, S; Wang, J; Xie, X; Zhou, K	1
Chen, T; Lee, SM; Li, C; Li, Y; Yi, X; Zheng, Y	1
Chen, T; Lee, SM; Li, C; Li, Y; Wang, R; Yi, X; Zheng, Y	1
Cao, YF; Fang, ZZ; Gonzalez, FJ; Liu, YZ; Sun, HZ; Sun, T; Wu, JJ; Yang, K; Yin, J; Zhao, J; Zhu, ZT	1
Ding, G; Guo, W; Liu, F; Lu, H; Zhan, Y; Zhang, M; Zheng, N	1
Chen, C; Ding, F; Liang, XM; Shi, YW; Tang, M; Wang, CP; Wang, ZW; Zhang, XC	1
Liu, CH; Lv, J; Tao, YY; Zhao, ZM; Zhu, CW	1
Bu, F; Cai, W; Jiao, Z; Li, L; Lin, HS; Ma, G; Shin, JG; Xiang, X; Zhang, H; Zhuang, X	1
Li, B; Li, D; Ma, F; Meng, X; Shi, L; Sun, X; Tian, J; Wang, Y	1
Chen, J; Gao, J; Jing, S; Li, H; Li, N; Liu, C; Sun, J; Sun, W; Wang, C; Yu, C	1
Bi, HC; Chen, X; Duan, WH; Huang, M; Qin, XL; Wang, HF; Wang, Y	1
Feng, YL; Li, W; Liu, KY; Liu, YL; Song, YG; Su, D; Yang, LJ	1
Cheng, X; Ding, XY; Ji, JD; Lu, TL; Mao, CQ; Su, LL; Wang, LJ; Zhang, J	1
Chen, T; Feng, Y; He, C; Hoi, MP; Lee, SM; Li, C; Tang, F; Zhang, C; Zheng, Y; Zhou, H	1
Cao, JQ; Deng, ZW; Du, SS; Geng, ZF; Guo, SS; Liang, JY; Pang, X; Wang, Y	1
Chen, C; Kang, D; Li, H; Li, X; Liang, Y; Shao, Y; Shen, B; Shen, J; Wang, G; Xie, L; Xu, Y; Yin, X; Zhu, Z	1
Chen, L; Fan, J; Li, M; Lu, X; Zhu, L	1
Cao, X; Gao, Z; Hu, T; Hu, Y; Qian, F; Su, F; Wang, Z; Yang, Y; Yu, K	1
Feng, W; Gao, L; Liu, ML; Mu, RF; Niu, LY; Wang, XG; Xu, BY; Zhou, LY	1
Chen, J; Li, H; Lin, C; Sun, J; Wang, C; Xu, Z; Yang, S	1
Ai, X; Dong, J; Han, G; Liu, Y; Song, J; Wang, Z; Yang, Q; Zhong, L	1
Dong, X; Du, X; Hao, X; Lin, L; Ni, J; Qu, C; Wu, H; Xie, L; Yin, X; Zhang, L	1
Gui, Y; Li, J; Tao, S; Xu, D; Yang, Y	1
Che, J; Chen, J; Cui, K; Li, H; Sun, J; Wang, C; Wang, H; Zhuang, W	1
Ding, L; Jiang, J; Li, Q; Liu, X; Wang, Z; Yang, L; Yu, S	1

Other Studies

63 other study(ies) available for schizandrer a and lignans

Article	Year
The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chemical & pharmaceutical bulletin, 1979, Volume: 27, Issue:6 Topics: Chemical Phenomena; Chemistry; Cyclooctanes; Cycloparaffins; Dioxoles; Lignans; Molecular Conformation; Plant Extracts; Plants, Medicinal; Polycyclic Compounds	1979
Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity. Chemico-biological interactions, 1982, Volume: 39, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; In Vitro Techniques; Lignans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Microsomes, Liver; Mutagens; NADP; Oxidation-Reduction; Plants, Medicinal; Polycyclic Compounds; Rats; Rats, Inbred Strains	1982
Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids. Chemico-biological interactions, 1982, Jul-15, Volume: 41, Issue:1 Topics: Animals; Carbon Tetrachloride; China; Cyclooctanes; Dioxoles; Lignans; Lipid Metabolism; Lipid Peroxides; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; NADP; Oxygen Consumption; Plants, Medicinal; Polycyclic Compounds	1982
Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils. British journal of pharmacology, 1994, Volume: 113, Issue:3 Topics: Animals; Calcium; Cyclic AMP; Cyclooctanes; Dioxoles; Fumarates; Inositol Phosphates; Lignans; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Respiratory Burst; Superoxides	1994
Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:12 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Enzyme Inhibitors; Erythromycin; Female; Humans; In Vitro Techniques; Ketoconazole; Lignans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microdialysis; Microsomes, Liver; Optical Rotation; Plant Extracts; Polycyclic Compounds; Schisandra; Solvents	2004
Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein. Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:1 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Daunorubicin; Dioxoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; Paclitaxel; Polycyclic Compounds; Prohibitins; Vincristine	2006
The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Peptides, 2006, Volume: 27, Issue:5 Topics: Combinatorial Chemistry Techniques; Cyclooctanes; Dioxoles; Drug Evaluation, Preclinical; Fluorescence Polarization; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Korea; Lignans; Medicine, East Asian Traditional; Peptide Library; Plant Extracts; Receptors, Neuropeptide; Schisandra	2006
[Lignans from different processed products of Schisandra chinensis fruits]. Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:6 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drug Compounding; Drugs, Chinese Herbal; Fruit; Hot Temperature; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra; Spectrometry, Mass, Electrospray Ionization	2008
Nortriterpenoids and lignans from Schisandra sphenanthera. Phytochemistry, 2008, Volume: 69, Issue:16 Topics: Cell Line; Cyclooctanes; Dioxoles; HeLa Cells; HIV-1; Humans; Lignans; Microbial Sensitivity Tests; Plant Extracts; Polycyclic Compounds; Schisandra; Triterpenes	2008
[Studies on the chemical constituents of Schisandra pubescens]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, Volume: 32, Issue:9 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Lactones; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal; Schisandra; Triterpenes	2009
A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera. Analytica chimica acta, 2010, Mar-03, Volume: 662, Issue:1 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Lignans; Mass Spectrometry; Plant Extracts; Polycyclic Compounds; Reproducibility of Results; Schisandra	2010
Schisantherin A exhibits anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells. Inflammation, 2010, Volume: 33, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cyclooctanes; Cyclooxygenase 2; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; I-kappa B Kinase; Inflammation Mediators; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lignans; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2010
Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. Phytotherapy research : PTR, 2011, Volume: 25, Issue:3 Topics: Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cyclooctanes; Dioxoles; Homocysteine; Lignans; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Polycyclic Compounds; Rats; Reactive Oxygen Species; Schisandra	2011
Identification of novel pregnane X receptor activators from traditional Chinese medicines. Journal of ethnopharmacology, 2011, Jun-14, Volume: 136, Issue:1 Topics: 4-Butyrolactone; Berberine; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Genes, Reporter; Hep G2 Cells; Herb-Drug Interactions; Humans; Lignans; Magnoliopsida; Medicine, Chinese Traditional; Plants, Medicinal; Pregnane X Receptor; Receptors, Steroid; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes	2011
Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography. Molecules (Basel, Switzerland), 2011, May-03, Volume: 16, Issue:5 Topics: Chromatography, Micellar Electrokinetic Capillary; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds	2011
Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Nov-15, Volume: 879, Issue:30 Topics: Adsorption; Analysis of Variance; Chromatography, Ion Exchange; Cyclooctanes; Dioxoles; Ethanol; Fruit; Hydrolysis; Ion Exchange Resins; Lignans; Plant Extracts; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Temperature	2011
[Influence of different processing method and mature stage on main chemical constituents of Schisandra chinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011, Volume: 36, Issue:13 Topics: Cyclooctanes; Dioxoles; Furaldehyde; Lignans; Oils, Volatile; Plant Extracts; Plants, Medicinal; Polysaccharides; Schisandra; Temperature; Time Factors	2011
Anti-inflammatory effect of heme oxygenase-1 toward Porphyromonas gingivalis lipopolysaccharide in macrophages exposed to gomisins A, G, and J. Journal of medicinal food, 2011, Volume: 14, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooctanes; Dioxoles; Fruit; Heme Oxygenase-1; Inflammation; Interleukin-1beta; Interleukin-6; Lignans; Lipopolysaccharides; Membrane Proteins; Mice; NF-kappa B; Plant Extracts; Polycyclic Compounds; Porphyromonas gingivalis; Schisandra; Signal Transduction; Tumor Necrosis Factor-alpha	2011
Homogeneous ionic liquid microextraction of the active constituents from fruits of Schisandra chinensis and Schisandra sphenanthera. Analytica chimica acta, 2012, Jan-27, Volume: 712 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Fruit; Imidazoles; Ionic Liquids; Lignans; Polycyclic Compounds; Schisandra	2012
[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker]. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:7 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Plants, Medicinal; Polycyclic Compounds; Quality Control; Schisandra	2012
Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS. Journal of separation science, 2013, Volume: 36, Issue:3 Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Polycyclic Compounds; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization	2013
Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction. Fitoterapia, 2012, Volume: 83, Issue:8 Topics: Cyclooctanes; Dioxoles; Glucuronosyltransferase; Herb-Drug Interactions; Lignans; Molecular Structure; Polycyclic Compounds; Protein Isoforms	2012
Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats. Journal of pharmaceutical and biomedical analysis, 2013, Apr-15, Volume: 77 Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Lignans; Male; Medicine, Chinese Traditional; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Schisandra; Sensitivity and Specificity; Sleep Initiation and Maintenance Disorders; Tandem Mass Spectrometry	2013
Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats. PloS one, 2013, Volume: 8, Issue:4 Topics: Animals; Apoptosis; Arrhythmias, Cardiac; Cardiotonic Agents; Caspase 3; Cyclooctanes; Cytoprotection; Dioxoles; Disease Models, Animal; Gene Expression Regulation; Hemodynamics; Hydrogen Peroxide; Lignans; Male; Malondialdehyde; Membrane Glycoproteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Polycyclic Compounds; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase	2013
In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:1 Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Humans; Lignans; Male; Microsomes, Liver; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Tablets; Tacrolimus	2014
Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways. Molecular nutrition & food research, 2014, Volume: 58, Issue:4 Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cyclic AMP-Dependent Protein Kinases; Cyclooctanes; Dioxoles; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mice, Inbred ICR; Microglia; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Polycyclic Compounds; Reactive Oxygen Species; STAT Transcription Factors; Toll-Like Receptor 2	2014
[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:1 Topics: Countercurrent Distribution; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Molecular Structure; Plants, Medicinal; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice. Physiology & behavior, 2014, Jun-10, Volume: 132 Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; Brain; Cognition Disorders; Cyclooctanes; Dioxoles; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Injections, Intraventricular; Lignans; Male; Malondialdehyde; Maze Learning; Mice; Mice, Inbred Strains; Neurodegenerative Diseases; Peptide Fragments; Superoxide Dismutase	2014
Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochemical and biophysical research communications, 2014, Jul-04, Volume: 449, Issue:3 Topics: Animals; Bone Resorption; Cell Differentiation; Cell Survival; Cyclooctanes; Dioxoles; Disease Models, Animal; Lignans; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteolysis; RANK Ligand; Signal Transduction	2014
Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. International immunopharmacology, 2014, Volume: 22, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Cyclooctanes; Cytokines; Dioxoles; Fruit; Humans; Lignans; Lipopolysaccharides; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Neutrophils; NF-kappa B; Phytotherapy; Plant Extracts; Respiratory Distress Syndrome; Schisandra; Signal Transduction	2014
Alleviation of severe inflammatory responses in LPS-exposed mice by Schisantherin A. Respiratory physiology & neurobiology, 2014, Oct-01, Volume: 202 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Movement; Cyclooctanes; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Lignans; Lipopolysaccharides; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Neutrophils; Peroxidase; Pulmonary Edema; Signal Transduction; Superoxide Dismutase; Survival Analysis	2014
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chemico-biological interactions, 2015, Apr-25, Volume: 231 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dioxoles; Lignans; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Polycyclic Compounds; Protective Agents; Schisandra	2015
Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neuroscience letters, 2015, Apr-23, Volume: 593 Topics: 1-Methyl-4-phenylpyridinium; Animals; Antiparkinson Agents; Brain; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-Binding Protein; Cyclooctanes; Dioxoles; Dopaminergic Neurons; Humans; Lignans; Male; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction	2015
Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe. Journal of ethnopharmacology, 2015, May-26, Volume: 166 Topics: Administration, Oral; Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Kidney; Lignans; Liver; Liver Cirrhosis; Male; Polycyclic Compounds; Rats; Rats, Wistar; Tissue Distribution	2015
[Determination of lignanoids in seeds of Schisandra chinensis by combinative methods of fingerprint and QAMS]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:9 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Lignans; Polycyclic Compounds; Reproducibility of Results; Schisandra; Seeds	2014
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. Journal of ethnopharmacology, 2015, Jul-21, Volume: 170 Topics: Animals; Antiparkinson Agents; Cell Line, Tumor; Cyclooctanes; Dioxoles; Dopaminergic Neurons; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lignans; Neuroblastoma; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Oxidopamine; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Schisandra; Signal Transduction; Zebrafish	2015
Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytotherapy research : PTR, 2015, Volume: 29, Issue:10 Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Glucuronosyltransferase; Herb-Drug Interactions; Lignans; Plant Extracts; Polycyclic Compounds; Rats; Schisandra; Structure-Activity Relationship	2015
Drug-drug interation prediction between ketoconazole and anti-liver cancer drug Gomisin G. African health sciences, 2015, Volume: 15, Issue:2 Topics: Antineoplastic Agents; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Drug Interactions; Humans; Ketoconazole; Lignans; Liver; Liver Neoplasms; Molecular Docking Simulation; Plant Extracts; Schisandra	2015
Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation. European journal of pharmacology, 2016, Jun-05, Volume: 780 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Chondrocytes; Cyclooctanes; Cyclooxygenase 2; Dinoprostone; Dioxoles; Enzyme Activation; Humans; Interleukin-1beta; Lignans; Matrix Metalloproteinases; Middle Aged; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis; Tumor Necrosis Factor-alpha	2016
Oral Delivery of a Nanocrystal Formulation of Schisantherin A with Improved Bioavailability and Brain Delivery for the Treatment of Parkinson's Disease. Molecular pharmaceutics, 2016, 11-07, Volume: 13, Issue:11 Topics: Administration, Oral; Animals; Brain; Cyclooctanes; Dioxoles; Disease Models, Animal; Drug Compounding; Lignans; Male; Nanoparticles; Parkinson Disease; Rats, Sprague-Dawley; Zebrafish	2016
Small-Sized mPEG-PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity. ACS applied materials & interfaces, 2017, Mar-22, Volume: 9, Issue:11 Topics: Animals; Brain; Cyclooctanes; Delayed-Action Preparations; Dioxoles; Dogs; Drug Carriers; Lignans; Nanoparticles; Particle Size; Polyesters; Polyethylene Glycols; Rats	2017
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. Fitoterapia, 2017, Volume: 119 Topics: Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Herb-Drug Interactions; Humans; Hydroxylation; Lignans; Midazolam; Molecular Structure; Nifedipine; Oxidation-Reduction; Schisandra; Testosterone	2017
Schisantherin A protects against liver ischemia-reperfusion injury via inhibition of mitogen-activated protein kinase pathway. International immunopharmacology, 2017, Volume: 47 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cyclooctanes; Dioxoles; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Humans; Lignans; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Reperfusion Injury; Schisandraceae; Signal Transduction	2017
Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways. Brain, behavior, and immunity, 2017, Volume: 66 Topics: Animals; Apoptosis; Brain Ischemia; Cell Survival; Cerebral Cortex; Cyclooctanes; Dioxoles; Inflammation; Lignans; Necrosis; Neurons; Neuroprotective Agents; Oxidative Stress; Parietal Lobe; Primary Cell Culture; Rats, Sprague-Dawley; Receptor, Anaphylatoxin C5a; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4	2017
[Effect of schisantherin A inhibit liver sinusoid endothelial cell function and action against liver fibrosis relating to angiogenesis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2016, Volume: 41, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Capillaries; Cell Movement; Cell Proliferation; Cyclooctanes; Dioxoles; Endothelial Cells; Humans; Lignans; Liver; Liver Cirrhosis; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Zebrafish	2016
Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:3 Topics: Area Under Curve; Biotransformation; China; Computational Biology; Computer Simulation; Cyclooctanes; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Expert Systems; Female; Humans; Immunosuppressive Agents; Lignans; Male; Models, Biological; Polycyclic Compounds; Protective Agents; Software; Tacrolimus	2018
Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF-kB pathway. Experimental animals, 2018, Nov-01, Volume: 67, Issue:4 Topics: Alanine Transaminase; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Animals; Aspartate Aminotransferases; Cyclooctanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Lignans; Liver; Liver Diseases, Alcoholic; Male; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Phytotherapy; Schisandra; Signal Transduction	2018
Schisantherin A Improves Learning and Memory of Mice with D-Galactose-Induced Learning and Memory Impairment Through Its Antioxidation and Regulation of p19/p53/p21/Cyclin D1/CDK4/RB Gene Expressions. Journal of medicinal food, 2018, Volume: 21, Issue:7 Topics: Animals; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p19; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Galactose; Gene Expression; Hippocampus; Humans; Learning Disabilities; Lignans; Male; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Retinoblastoma Protein; rho GTP-Binding Proteins; Schisandra; Tumor Suppressor Protein p53	2018
[Determination of hepatic and small intestinal distribution of lignans of Wuzhi tablet in rats by liquid chromatography tandem mass spectrometry method]. Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:12 Topics: Animals; Chromatography, Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Intestine, Small; Lignans; Liver; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Schisandra; Tablets; Tandem Mass Spectrometry	2016
[Rapid identification of the different constituents in Fructus Schisandrae Chinensis before and after processing by UHPLC-QTOF/MS~E combining with metabonomics]. Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:9 Topics: Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Fruit; Lignans; Metabolomics; Polycyclic Compounds; Schisandra	2016
[Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS]. Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:10 Topics: Acetic Acid; Animals; Bile; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Feces; Lignans; Liver Diseases, Alcoholic; Plasma; Polycyclic Compounds; Rats; Schisandra; Urine	2016
Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 47, Issue:5 Topics: Animals; Cell Line, Transformed; Cyclooctanes; Dioxoles; Inflammation; Lignans; MAP Kinase Signaling System; Mice; Microglia; NF-E2-Related Factor 2; Phosphorylation	2018
Chemical constituents isolated from stems of Natural product research, 2020, Volume: 34, Issue:18 Topics: Animals; Cyclooctanes; Dioxoles; Feeding Behavior; Lignans; Plant Stems; Polycyclic Compounds; Schisandra; Sesquiterpenes; Structure-Activity Relationship; Tribolium; Triterpenes	2020
Systematically identifying the hepatoprotective ingredients of schisandra lignan extract from pharmacokinetic and pharmacodynamic perspectives. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 53 Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cyclooctanes; Dioxoles; Drug Evaluation, Preclinical; Lignans; Liver; Male; Mass Spectrometry; Mice, Inbred BALB C; Plant Extracts; Protective Agents; Rats, Sprague-Dawley; Schisandra	2019
The Pharmacokinetic Prediction of Cyclosporin A after Coadministration with Wuzhi Capsule. AAPS PharmSciTech, 2019, Jul-08, Volume: 20, Issue:6 Topics: Adult; Cyclooctanes; Cyclosporine; Dioxoles; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Immunosuppressive Agents; Lignans; Male; Polycyclic Compounds	2019
Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells. Biochemical pharmacology, 2020, Volume: 173 Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Movement; Cyclooctanes; Dioxoles; G2 Phase Cell Cycle Checkpoints; Humans; Lignans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Molecular Structure; Phosphorylation; Plant Extracts; Reactive Oxygen Species; Schisandra; Stomach Neoplasms	2020
Screening and Identification of the Main Metabolites of Schisantherin a In Vivo and In Vitro by Using UHPLC-Q-TOF-MS/MS. Molecules (Basel, Switzerland), 2020, Jan-08, Volume: 25, Issue:2 Topics: Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Dioxoles; Drug Evaluation, Preclinical; Ions; Lignans; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Oxidation-Reduction; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2020
Schisantherin A causes endothelium-dependent and -independent vasorelaxation in isolated rat thoracic aorta. Life sciences, 2020, Mar-15, Volume: 245 Topics: Animals; Aorta, Thoracic; Blotting, Western; Calcium; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Endothelium, Vascular; Lignans; Male; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vasodilation; Vasodilator Agents	2020
Effects of 27 natural products on drug metabolism genes in channel catfish ( Xenobiotica; the fate of foreign compounds in biological systems, 2020, Volume: 50, Issue:9 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Biotransformation; Cell Line; Cyclooctanes; Cytochrome P-450 Enzyme System; Dioxoles; Ictaluridae; Lignans; Polycyclic Compounds; Pregnane X Receptor	2020
Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 127 Topics: Animals; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Epithelium, Corneal; Female; Humans; Lignans; Mice; Plant Extracts; Polycyclic Compounds	2020
Schisantherin A attenuates sepsis-induced acute kidney injury by suppressing inflammation via regulating the NRF2 pathway. Life sciences, 2020, Oct-01, Volume: 258 Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooctanes; Dioxoles; Inflammation; Kidney; Lignans; Male; Mice; NF-E2-Related Factor 2; Rats; Sepsis; Signal Transduction	2020
Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Jul-15, Volume: 88 Topics: Animals; Cell Line; Cyclooctanes; Cytokines; Dioxoles; Hepatic Stellate Cells; Lignans; Liver Cirrhosis; Male; MAP Kinase Kinase Kinases; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; Rats; Signal Transduction; Thioacetamide; Transforming Growth Factor beta1	2021
Schisantherin A alleviates non-alcoholic fatty liver disease by restoring intestinal barrier function. Frontiers in cellular and infection microbiology, 2022, Volume: 12 Topics: Animals; Anti-Bacterial Agents; Cyclooctanes; Dioxoles; Inflammation; Lignans; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Ribosomal, 16S; Toll-Like Receptor 4	2022