Compounds > sch 58261

Page last updated: 2024-09-05

sch 58261 and cgs 15943

sch 58261 has been researched along with cgs 15943 in 8 studies

Compound Research Comparison

Studies (sch 58261)	Trials (sch 58261)	Recent Studies (post-2010) (sch 58261)	Studies (cgs 15943)	Trials (cgs 15943)	Recent Studies (post-2010) (cgs 15943)
46	0	14	139	0	28

Protein Interaction Comparison

Protein	Taxonomy	sch 58261 (IC50)	cgs 15943 (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)		0.97
Adenosine receptor A3	Homo sapiens (human)		0.406
Adenosine receptor A1	Rattus norvegicus (Norway rat)		0.006
Adenosine receptor A3	Rattus norvegicus (Norway rat)		0.0607
Adenosine receptor A2a	Homo sapiens (human)		0.012
Adenosine receptor A2b	Homo sapiens (human)		0.6304
Adenosine receptor A2b	Rattus norvegicus (Norway rat)		0.0028
Adenosine receptor A2a	Rattus norvegicus (Norway rat)		0.0029
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)		1.28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)		8.48
Casein kinase I isoform alpha	Homo sapiens (human)		0.82
Casein kinase I isoform delta	Homo sapiens (human)		0.24
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)		0.11
Casein kinase I isoform epsilon	Homo sapiens (human)		0.49
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)		0.14

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (62.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Daly, JW; Jacobson, KA; Melman, N; Padgett, WL; Shi, D; Siddiqi, SM; van Rhee, AM	1
Baraldi, PG; Cacciari, B; Dionisotti, S; Ongini, E; Pineda de las Infantas y Villatoro, MJ; Spalluto, G; Zocchi, C	1
Arslan, G; Dionisotti, S; Fredholm, BB; Kull, B; Ongini, E; Zocchi, C	1
Baraldi, PG; Bergonzoni, M; Borea, PA; Cacciari, B; Dionisotti, S; Ongini, E; Spalluto, G; Varani, K	1
Dionisotti, S; Fredholm, BB; Gessi, S; Irenius, E; Ongini, E	1
Beukers, MW; Brussee, J; de Graaf, O; de Vries, H; Göblyös, A; Ijzerman, AP; Link, R; Mantri, M; Mulder-Krieger, T; van Veldhoven, J; von Frijtag Drabbe Künzel, JK	1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L	1
de Lera Ruiz, M; Lim, YH; Zheng, J	1

Reviews

2 review(s) available for sch 58261 and cgs 15943

Article	Year
Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1 Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1	2013
Adenosine A2A receptor as a drug discovery target. Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction	2014

Other Studies

6 other study(ies) available for sch 58261 and cgs 15943

Article	Year
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists. Journal of medicinal chemistry, 1996, Jan-19, Volume: 39, Issue:2 Topics: Animals; Binding Sites; Humans; Male; Mice; Models, Molecular; Motor Activity; Purinergic P1 Receptor Antagonists; Rats; Structure-Activity Relationship; Thiophenes	1996
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists. Journal of medicinal chemistry, 1996, Mar-01, Volume: 39, Issue:5 Topics: Animals; Binding, Competitive; Brain; Male; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Antagonists; Pyrimidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Structure-Activity Relationship; Triazoles	1996
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Species Specificity; Transfection; Triazoles	1997
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists. Journal of medicinal chemistry, 1998, Jun-04, Volume: 41, Issue:12 Topics: Adenosine; Animals; Binding, Competitive; Blood Platelets; CHO Cells; Corpus Striatum; Cricetinae; Cyclic AMP; Drug Design; Humans; Male; Mice; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Thermodynamics; Tumor Cells, Cultured	1998
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:1 Topics: Animals; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Rats; Transfection; Triazines; Triazoles; Xanthines	1999
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Adenosine A2 Receptor Antagonists; Amines; Animals; Cell Line; Cricetinae; Cyclic AMP; Furans; Humans; Models, Molecular; Molecular Structure; Nicotinic Acids; Nitriles; Receptor, Adenosine A2A; Structure-Activity Relationship	2008