sch 51048 has been researched along with posaconazole in 2 studies
| Studies (sch 51048) | Trials (sch 51048) | Recent Studies (post-2010) (sch 51048) | Studies (posaconazole) | Trials (posaconazole) | Recent Studies (post-2010) (posaconazole) |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 1,575 | 103 | 1,014 |
| Protein | Taxonomy | sch 51048 (IC50) | posaconazole (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 8.1 | |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | 0.921 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.2458 | |
| Aromatase | Homo sapiens (human) | 8.4 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 7.2 | |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | 0.31 | |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | 0.021 | |
| Sterol 14-alpha demethylase | Trypanosoma cruzi strain CL Brener | 0.464 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bennett, F; Cacciapuoti, A; Ganguly, AK; Girijavallabhan, VM; Hare, RS; Jao, E; Liu, YT; Loebenberg, D; Lovey, RG; Menzel, F; Moss, E; Nomeir, A; Patel, NM; Pike, R; Pinto, P; Saksena, AK; Wang, H | 1 |
| Bartner, P; Bennett, F; Cacciapuoti, A; Ganguly, AK; Girijavallabhan, V; Hare, R; Heimark, L; Hilbert, M; Korfmacher, W; Kumari, P; Lin, CC; Liu, YT; Loebenberg, D; Lovey, R; McNamara, P; Miller, G; Nomeir, AA; Pickett, C; Pike, R; Pramanik, BN; Saksena, A; Veals, J; Wang, H | 1 |
2 other study(ies) available for sch 51048 and posaconazole
| Article | Year |
|---|---|
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].
Topics: Alcohols; Animals; Antifungal Agents; Aspergillosis; Candidiasis; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Haplorhini; Humans; Immunosuppressive Agents; Mice; Models, Chemical; Time Factors; Triazoles | 2006 |
Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
Topics: Animals; Antifungal Agents; Chromatography, High Pressure Liquid; Dogs; Drug Design; Macaca fascicularis; Male; Mass Spectrometry; Mice; Mice, Inbred Strains; Rabbits; Triazoles | 2008 |