sch 42495 has been researched along with methionine in 18 studies
| Studies (sch 42495) | Trials (sch 42495) | Recent Studies (post-2010) (sch 42495) | Studies (methionine) | Trials (methionine) | Recent Studies (post-2010) (methionine) |
|---|---|---|---|---|---|
| 18 | 5 | 0 | 27,485 | 530 | 5,020 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (77.78) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alton, KB; Alvarez, N; Hernandez, A; Patrick, JE | 1 |
| Forlani, A; Monopoli, A; Ongini, E | 1 |
| Chiu, PJ; Sybertz, EJ; Vemulapalli, S; Watkins, RW | 1 |
| Gregoire, JR; Sheps, SG | 1 |
| Ardeleani, G; Casati, C; Monopoli, A; Morganti, A; Ongini, E; Sala, C; Zanchetti, A | 1 |
| Masuo, K; Mikami, H; Nagano, M; Ogihara, T; Rakugi, H; Yu, H | 1 |
| Morice, AH; Sheedy, W; Thompson, JS | 2 |
| Crozier, IG; Espiner, EA; Nicholls, MG; Richards, AM; Yandle, TG | 1 |
| Crozier, IG; Espiner, EA; Frampton, C; Ikram, H; Kosoglou, T; Nicholls, MG; Rallings, M; Richards, AM; Yandle, TG | 1 |
| Banfield, CR; Batra, V; Fettner, SH; Kosoglou, T; Pai, S; Zhu, GR | 1 |
| Allen, TJ; Burrell, LM; Cooper, ME; Johnston, CI; Rockell, MD; Tikkanen, I; Tikkanen, T | 1 |
| Espiner, EA; Lainchbury, JG; Nicholls, MG; Richards, AM; Yandle, TG | 1 |
| Stuhr, LE | 1 |
| Burrell, LM; Farina, NK; Johnston, CI | 1 |
| Balding, LC; Burrell, LM; Farina, NK; Johnston, CI | 1 |
| Carpenter, TC; Stenmark, KR | 1 |
1 review(s) available for sch 42495 and methionine
| Article | Year |
|---|---|
Newer antihypertensive drugs.
Topics: Antihypertensive Agents; Dibenzothiepins; Humans; Imidazoles; Methionine; Oxazoles; Piperazines; Protease Inhibitors; Rilmenidine | 1995 |
5 trial(s) available for sch 42495 and methionine
| Article | Year |
|---|---|
Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension.
Topics: Aged; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Female; Heart Rate; Humans; Hypertension; Male; Methionine; Middle Aged; Neprilysin | 1994 |
Plasma brain natriuretic peptide and endopeptidase 24.11 inhibition in hypertension.
Topics: Adult; Aged; Angiotensin II; Atrial Natriuretic Factor; Double-Blind Method; Humans; Hypertension; Indans; Male; Methionine; Middle Aged; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Posture; Propionates; Time Factors | 1993 |
Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension.
Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Guanosine Monophosphate; Heart Rate; Humans; Hypertension; Male; Methionine; Middle Aged; Natriuresis; Neprilysin; Norepinephrine; Renin-Angiotensin System; Sodium; Sympathetic Nervous System; Time Factors | 1993 |
Pharmacokinetic-pharmacodynamic (PK-PD) modeling for a new antihypertensive agent (neutral metalloendopeptidase inhibitor SCH 42354) in patients with mild to moderate hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Humans; Hypertension; Male; Methionine; Middle Aged; Placebos; Prodrugs; Protease Inhibitors | 1995 |
Brain natriuretic peptide and neutral endopeptidase inhibition in left ventricular impairment.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Cyclic GMP; Drug Synergism; Humans; Male; Metabolic Clearance Rate; Methionine; Middle Aged; Natriuresis; Natriuretic Peptide, Brain; Neprilysin; Protease Inhibitors; Renin; Ventricular Dysfunction, Left | 1999 |
12 other study(ies) available for sch 42495 and methionine
| Article | Year |
|---|---|
High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric de
Topics: Chromatography, High Pressure Liquid; Gold; Humans; Hypertension; Mercury; Methionine; Neprilysin; Sulfhydryl Compounds | 1992 |
Chronic inhibition of neutral endopeptidase reduces left ventricular hypertrophy without changing blood pressure in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Dioxolanes; Dipeptides; Enalapril; Hypertension; Methionine; Myocardium; Neprilysin; Rats; Rats, Inbred SHR | 1991 |
Neutral metalloendopeptidase inhibition: a novel means of circulatory modulation.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Bradykinin; Desoxycorticosterone; Dioxolanes; Dipeptides; Hypertension; Male; Methionine; Neprilysin; Rats; Rats, Inbred Strains; Sodium, Dietary | 1990 |
Hemodynamic and humoral effects of chronic treatment with the neutral endopeptidase inhibitor SCH 42495 in spontaneously hypertensive rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cyclic GMP; Diuresis; Enalapril; Hemodynamics; Hypertension; Male; Methionine; Natriuresis; Neprilysin; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 1994 |
Neutral endopeptidase (NEP) inhibition in rats with established pulmonary hypertension secondary to chronic hypoxia.
Topics: Animals; Atrial Natriuretic Factor; Body Weight; Chronic Disease; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Methionine; Myocardium; Neprilysin; Pulmonary Circulation; Rats; Rats, Wistar | 1994 |
Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats.
Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Heart Ventricles; Hypertrophy, Right Ventricular; Hypoxia; Male; Methionine; Neprilysin; Pulmonary Veins; Rats; Rats, Wistar | 1994 |
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Glucose; Blood Pressure; Body Weight; Captopril; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hypertension; Male; Methionine; Neprilysin; Propionates; Rats; Rats, Inbred SHR; Renal Circulation; Renin; Sulfhydryl Compounds | 1998 |
SCH 42495.
Topics: Drugs, Investigational; Endopeptidases; Heart Failure; Humans; Hypertension; Methionine; Prodrugs; Protease Inhibitors | 1999 |
Effects of SCH 42495, a neutral endopeptidase inhibitor, on cardiac function and mass in rats after repeated hyperbaric exposures.
Topics: Adaptation, Physiological; Animals; Blood Pressure; Heart; Helium; Hyperbaric Oxygenation; Hypertrophy, Left Ventricular; Male; Methionine; Myocardium; Neprilysin; Nitrogen; Organ Size; Oxygen; Protease Inhibitors; Rats; Rats, Wistar; Ventricular Function, Left | 2000 |
Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cardiomegaly; Enzyme Inhibitors; Fibrosis; Hypertension; Kidney; Male; Methionine; Myocardium; Neprilysin; Organ Size; Propionates; Protease Inhibitors; Rats; Rats, Inbred SHR; Renin; Sulfhydryl Compounds | 2000 |
Beneficial renal and cardiac effects of vasopeptidase inhibition with S21402 in heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Captopril; Cardiovascular System; Disease Models, Animal; Female; Heart Failure; Hormones; Kidney; Methionine; Myocardial Infarction; Neprilysin; Propionates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Water | 2000 |
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water | 2001 |