Page last updated: 2024-09-03

sch 42495 and methionine

sch 42495 has been researched along with methionine in 18 studies

Compound Research Comparison

Studies
(sch 42495)
Trials
(sch 42495)
Recent Studies (post-2010)
(sch 42495)
Studies
(methionine)
Trials
(methionine)
Recent Studies (post-2010) (methionine)
185027,4855305,020

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (77.78)18.2507
2000's4 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alton, KB; Alvarez, N; Hernandez, A; Patrick, JE1
Forlani, A; Monopoli, A; Ongini, E1
Chiu, PJ; Sybertz, EJ; Vemulapalli, S; Watkins, RW1
Gregoire, JR; Sheps, SG1
Ardeleani, G; Casati, C; Monopoli, A; Morganti, A; Ongini, E; Sala, C; Zanchetti, A1
Masuo, K; Mikami, H; Nagano, M; Ogihara, T; Rakugi, H; Yu, H1
Morice, AH; Sheedy, W; Thompson, JS2
Crozier, IG; Espiner, EA; Nicholls, MG; Richards, AM; Yandle, TG1
Crozier, IG; Espiner, EA; Frampton, C; Ikram, H; Kosoglou, T; Nicholls, MG; Rallings, M; Richards, AM; Yandle, TG1
Banfield, CR; Batra, V; Fettner, SH; Kosoglou, T; Pai, S; Zhu, GR1
Allen, TJ; Burrell, LM; Cooper, ME; Johnston, CI; Rockell, MD; Tikkanen, I; Tikkanen, T1
Espiner, EA; Lainchbury, JG; Nicholls, MG; Richards, AM; Yandle, TG1
Stuhr, LE1
Burrell, LM; Farina, NK; Johnston, CI1
Balding, LC; Burrell, LM; Farina, NK; Johnston, CI1
Carpenter, TC; Stenmark, KR1

Reviews

1 review(s) available for sch 42495 and methionine

ArticleYear
Newer antihypertensive drugs.
    Current opinion in cardiology, 1995, Volume: 10, Issue:5

    Topics: Antihypertensive Agents; Dibenzothiepins; Humans; Imidazoles; Methionine; Oxazoles; Piperazines; Protease Inhibitors; Rilmenidine

1995

Trials

5 trial(s) available for sch 42495 and methionine

ArticleYear
Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension.
    American journal of hypertension, 1994, Volume: 7, Issue:11

    Topics: Aged; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Female; Heart Rate; Humans; Hypertension; Male; Methionine; Middle Aged; Neprilysin

1994
Plasma brain natriuretic peptide and endopeptidase 24.11 inhibition in hypertension.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:2

    Topics: Adult; Aged; Angiotensin II; Atrial Natriuretic Factor; Double-Blind Method; Humans; Hypertension; Indans; Male; Methionine; Middle Aged; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Posture; Propionates; Time Factors

1993
Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:1

    Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Double-Blind Method; Guanosine Monophosphate; Heart Rate; Humans; Hypertension; Male; Methionine; Middle Aged; Natriuresis; Neprilysin; Norepinephrine; Renin-Angiotensin System; Sodium; Sympathetic Nervous System; Time Factors

1993
Pharmacokinetic-pharmacodynamic (PK-PD) modeling for a new antihypertensive agent (neutral metalloendopeptidase inhibitor SCH 42354) in patients with mild to moderate hypertension.
    European journal of clinical pharmacology, 1995, Volume: 48, Issue:5

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Humans; Hypertension; Male; Methionine; Middle Aged; Placebos; Prodrugs; Protease Inhibitors

1995
Brain natriuretic peptide and neutral endopeptidase inhibition in left ventricular impairment.
    The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:2

    Topics: Adult; Aged; Aldosterone; Blood Pressure; Cyclic GMP; Drug Synergism; Humans; Male; Metabolic Clearance Rate; Methionine; Middle Aged; Natriuresis; Natriuretic Peptide, Brain; Neprilysin; Protease Inhibitors; Renin; Ventricular Dysfunction, Left

1999

Other Studies

12 other study(ies) available for sch 42495 and methionine

ArticleYear
High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric de
    Journal of chromatography, 1992, Sep-02, Volume: 579, Issue:2

    Topics: Chromatography, High Pressure Liquid; Gold; Humans; Hypertension; Mercury; Methionine; Neprilysin; Sulfhydryl Compounds

1992
Chronic inhibition of neutral endopeptidase reduces left ventricular hypertrophy without changing blood pressure in spontaneously hypertensive rats.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Dioxolanes; Dipeptides; Enalapril; Hypertension; Methionine; Myocardium; Neprilysin; Rats; Rats, Inbred SHR

1991
Neutral metalloendopeptidase inhibition: a novel means of circulatory modulation.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1990, Volume: 8, Issue:7

    Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Bradykinin; Desoxycorticosterone; Dioxolanes; Dipeptides; Hypertension; Male; Methionine; Neprilysin; Rats; Rats, Inbred Strains; Sodium, Dietary

1990
Hemodynamic and humoral effects of chronic treatment with the neutral endopeptidase inhibitor SCH 42495 in spontaneously hypertensive rats.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:5

    Topics: Administration, Oral; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cyclic GMP; Diuresis; Enalapril; Hemodynamics; Hypertension; Male; Methionine; Natriuresis; Neprilysin; Rats; Rats, Inbred SHR; Renin-Angiotensin System

1994
Neutral endopeptidase (NEP) inhibition in rats with established pulmonary hypertension secondary to chronic hypoxia.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Animals; Atrial Natriuretic Factor; Body Weight; Chronic Disease; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Methionine; Myocardium; Neprilysin; Pulmonary Circulation; Rats; Rats, Wistar

1994
Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats.
    Clinical science (London, England : 1979), 1994, Volume: 87, Issue:1

    Topics: Animals; Atrial Natriuretic Factor; Chronic Disease; Heart Ventricles; Hypertrophy, Right Ventricular; Hypoxia; Male; Methionine; Neprilysin; Pulmonary Veins; Rats; Rats, Wistar

1994
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:4

    Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Glucose; Blood Pressure; Body Weight; Captopril; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hypertension; Male; Methionine; Neprilysin; Propionates; Rats; Rats, Inbred SHR; Renal Circulation; Renin; Sulfhydryl Compounds

1998
SCH 42495.
    Drugs in R&D, 1999, Volume: 1, Issue:4

    Topics: Drugs, Investigational; Endopeptidases; Heart Failure; Humans; Hypertension; Methionine; Prodrugs; Protease Inhibitors

1999
Effects of SCH 42495, a neutral endopeptidase inhibitor, on cardiac function and mass in rats after repeated hyperbaric exposures.
    Scandinavian journal of clinical and laboratory investigation, 2000, Volume: 60, Issue:2

    Topics: Adaptation, Physiological; Animals; Blood Pressure; Heart; Helium; Hyperbaric Oxygenation; Hypertrophy, Left Ventricular; Male; Methionine; Myocardium; Neprilysin; Nitrogen; Organ Size; Oxygen; Protease Inhibitors; Rats; Rats, Wistar; Ventricular Function, Left

2000
Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs.
    Journal of hypertension, 2000, Volume: 18, Issue:6

    Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Cardiomegaly; Enzyme Inhibitors; Fibrosis; Hypertension; Kidney; Male; Methionine; Myocardium; Neprilysin; Organ Size; Propionates; Protease Inhibitors; Rats; Rats, Inbred SHR; Renin; Sulfhydryl Compounds

2000
Beneficial renal and cardiac effects of vasopeptidase inhibition with S21402 in heart failure.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Captopril; Cardiovascular System; Disease Models, Animal; Female; Heart Failure; Hormones; Kidney; Methionine; Myocardial Infarction; Neprilysin; Propionates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Water

2000
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water

2001