sc 8109 has been researched along with spironolactone in 11 studies
| Studies (sc 8109) | Trials (sc 8109) | Recent Studies (post-2010) (sc 8109) | Studies (spironolactone) | Trials (spironolactone) | Recent Studies (post-2010) (spironolactone) |
|---|---|---|---|---|---|
| 11 | 1 | 0 | 7,222 | 960 | 1,923 |
| Protein | Taxonomy | sc 8109 (IC50) | spironolactone (IC50) |
|---|---|---|---|
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Estrogen receptor | Homo sapiens (human) | 5.702 | |
| Glucocorticoid receptor | Homo sapiens (human) | 4.0745 | |
| Progesterone receptor | Homo sapiens (human) | 1.675 | |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Mineralocorticoid receptor | Homo sapiens (human) | 0.0315 | |
| Androgen receptor | Homo sapiens (human) | 0.3585 | |
| Androgen receptor | Rattus norvegicus (Norway rat) | 0.406 | |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 6.92 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Claire, M; Corvol, P; Geering, K; Oblin, ME; Rossier, B | 1 |
| Harrison, IR; McInnes, GT; Perkins, RM; Shelton, JR | 1 |
| CARBONE, JV; DOOLAN, PD; HUTCHIN, ME; WIGGINS, RA | 1 |
| BAILEY, RE | 1 |
| MALVIN, RL; VANDER, AJ; WILDE, WS | 1 |
| TANZ, RD | 1 |
| FRAWLEY, TF; KISTLER, H | 1 |
| SINGER, B | 1 |
| LUPULESCU, A | 1 |
| KOCZOREK, KR; MOLL, HC | 1 |
| Cole, DF | 1 |
1 review(s) available for sc 8109 and spironolactone
| Article | Year |
|---|---|
Mechanism of the antimineralocorticoid effects of spirolactones.
Topics: Aldosterone; Animals; Anura; Canrenoic Acid; Canrenone; Cattle; Guinea Pigs; Humans; Male; Mineralocorticoid Receptor Antagonists; Rats; Receptors, Steroid; Spironolactone; Veratrum Alkaloids | 1981 |
1 trial(s) available for sc 8109 and spironolactone
| Article | Year |
|---|---|
Quantitative comparison of aldosterone antagonists in normal human subjects: prediction of therapeutic potency.
Topics: Adult; Biological Assay; Creatinine; Dose-Response Relationship, Drug; Humans; Male; Mineralocorticoid Receptor Antagonists; Potassium; Sodium; Spironolactone | 1981 |
9 other study(ies) available for sc 8109 and spironolactone
| Article | Year |
|---|---|
Effect of spirolactone SC 8109 on renal function in normal human subjects.
Topics: Aldosterone; Diuretics; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Spironolactone; Urinary Tract Physiological Phenomena | 1959 |
Acute effects of corticosteroid mixtures and the 17-spirolactone SC-8109 on sodium, potassium, and water excretion in adrenalectomized, water-loaded rats.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biological Transport; Body Fluids; Mineralocorticoid Receptor Antagonists; Potassium; Rats; Sodium; Spironolactone; Water | 1960 |
Stop flow analysis of aldosterone and steroidal antagonist SC-8109 on renal tubular sodium transport kinetics.
Topics: Aldosterone; Diuretics; Humans; Ion Transport; Kidney; Kinetics; Mineralocorticoid Receptor Antagonists; Sodium; Sodium, Dietary; Spironolactone | 1960 |
Studies on the inotropic action of aldosterone on isolated cardiac tissue preparations; including the effects of pH, ouabain and SC-8109.
Topics: Aldosterone; Diuretics; Heart; Hydrogen-Ion Concentration; Mineralocorticoid Receptor Antagonists; Ouabain; Spironolactone; Strophanthins | 1962 |
Effects of a spirolactone (SC-8109) in primary mineralocorticoid excess.
Topics: Adrenal Cortex Hormones; Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Spironolactone | 1960 |
Effect of aldosterone-antagonist, SC 8109, on the secretion of aldosterone in normal rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Mineralocorticoid Receptor Antagonists; Rats; Spironolactone | 1959 |
Effects of an aldosterone-antagonist (SC-8109) on radio-sodium (Na22) metabolism in rats with hypothalamic lesions.
Topics: Aldosterone; Animals; Antihypertensive Agents; Disease; Diuretics; Hormone Antagonists; Hypothalamus; Mineralocorticoid Receptor Antagonists; Rats; Sodium; Sodium, Dietary; Spironolactone | 1961 |
[On the influence of an aldosterone antagonist (SC-8109) on the absorption of sodium from the gastrointestinal tract of rats].
Topics: Aldosterone; Animals; Antihypertensive Agents; Diuretics; Gastrointestinal Tract; Mineralocorticoid Receptor Antagonists; Rats; Sodium; Sodium, Dietary; Spironolactone | 1962 |
REDUCTION IN AQUEOUS HUMOUR FORMATION AS CAUSED BY IODATE, SPIROLACTONE, AND POLYPHLORETIN PHOSPHATE.
Topics: Animals; Aqueous Humor; Biological Transport, Active; Blood-Aqueous Barrier; Body Water; Chlorides; Ciliary Body; Infusions, Intra-Arterial; Infusions, Intravenous; Intraocular Pressure; Iodates; Male; Mineralocorticoid Receptor Antagonists; Polyphloretin Phosphate; Prostaglandin Antagonists; Rabbits; Sodium; Spironolactone | 1962 |