sc 58125 has been researched along with sc 560 in 8 studies
| Studies (sc 58125) | Trials (sc 58125) | Recent Studies (post-2010) (sc 58125) | Studies (sc 560) | Trials (sc 560) | Recent Studies (post-2010) (sc 560) |
|---|---|---|---|---|---|
| 93 | 0 | 15 | 274 | 1 | 76 |
| Protein | Taxonomy | sc 58125 (IC50) | sc 560 (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.0279 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.0301 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 2.4653 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertenshaw, SR; Burton, EG; Carter, JS; Cogburn, JN; Collins, PW; Docter, S; Graneto, MJ; Gregory, SA; Isakson, PC; Koboldt, CM; Lee, LF; Malecha, JW; Miyashiro, JM; Penning, TD; Perkins, WE; Rogers, RS; Rogier, DJ; Seibert, K; Talley, JJ; Veenhuizen, AW; Yu, SS; Zhang, YY | 1 |
| Drenan, RM; Gabot, K; Gregorian, C; Insel, PA; Ostrom, RS; Rana, BK | 1 |
| Conway, CM; Dirig, DM; Isakson, PC; Luo, ZD; Svensson, C; Yaksh, TL | 1 |
| Alston-Mills, B; Bottone, FG; Eling, TE; Martinez, JM | 1 |
| Bottone, FG; Eling, TE; Ishibashi, M; Kamitani, H; Taniura, S; Watanabe, T | 1 |
| Kajiyama, S; Kawamoto, M; Kurita, S; Matsunaga, A; Shiraishi, S; Yasuda, T; Yuge, O | 1 |
| Bischoff, A; Bucher, M; Gekle, M; Sauvant, C | 1 |
| Birnbaum, Y; Kodakandla, M; Ling, S; Nanhwan, MK; Nylander, S; Ye, Y | 1 |
8 other study(ies) available for sc 58125 and sc 560
| Article | Year |
|---|---|
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hyperalgesia; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Membrane Proteins; Molecular Structure; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 1997 |
Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Cell Line; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Dogs; Enzyme Inhibitors; Isoenzymes; Molecular Sequence Data; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; RNA, Messenger; Signal Transduction; Sulfonamides | 2001 |
The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Ibuprofen; Injections, Intraperitoneal; Injections, Spinal; Isoenzymes; Male; Membrane Proteins; N-Methylaspartate; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells.
Topics: Apoptosis; Carcinoma; Cell Division; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Tumor Cells, Cultured | 2004 |
The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Line, Tumor; Cyclooxygenase Inhibitors; Densitometry; Dose-Response Relationship, Drug; Etoposide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Indomethacin; Kinetics; Laminin; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Sulindac | 2005 |
Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dinoprostone; Hyperalgesia; Injections, Spinal; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Streptozocin | 2007 |
Differential effect of COX1 and COX2 inhibitors on renal outcomes following ischemic acute kidney injury.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Down-Regulation; Glomerular Filtration Rate; Kidney; Kidney Tubules, Proximal; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Pyrazoles; Rats; Reperfusion Injury; RNA, Messenger | 2014 |
Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Aspirin; Cardiotonic Agents; Clopidogrel; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Enzyme Induction; Lipoxins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Pyrazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Ticagrelor; Ticlopidine; Triazoles; Up-Regulation | 2014 |