sc 58125 has been researched along with n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide in 21 studies
| Studies (sc 58125) | Trials (sc 58125) | Recent Studies (post-2010) (sc 58125) | Studies (n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide) | Trials (n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide) | Recent Studies (post-2010) (n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide) |
|---|---|---|---|---|---|
| 93 | 0 | 15 | 1,220 | 3 | 229 |
| Protein | Taxonomy | sc 58125 (IC50) | n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (IC50) |
|---|---|---|---|
| Prostaglandin E synthase | Homo sapiens (human) | 10 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 2.1 | |
| Aromatase | Homo sapiens (human) | 0.68 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 1.67 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 3 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.9037 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 2.4333 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.1522 | |
| Carboxypeptidase B2 | Homo sapiens (human) | 1.8 | |
| Prostaglandin E synthase | Mus musculus (house mouse) | 0.007 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, GD; Burton, EG; Cogburn, JN; Collins, JT; Garland, DJ; Gregory, SA; Huang, HC; Isakson, PC; Koboldt, CM; Li, JJ | 1 |
| Anderson, GD; Collins, JT; Gregory, SA; Koboldt, CM; Li, JJ; Norton, MB; Perkins, WE; Reinhard, EJ; Reitz, DB; Seibert, K | 1 |
| Bornemeier, DA; Chan, K; Connor, DT; Doubleday, R; Dyer, RD; Gilbertsen, RB; Guglietta, A; Roth, BD; Schrier, DJ; Sercel, AD; Song, Y; Sorenson, RJ; Unangst, PC | 1 |
| Beylin, VG; Bornemeier, DA; Chan, K; Connor, DT; Doubleday, R; Dyer, RD; Gilbertsen, RB; Guglietta, A; Roth, BD; Schrier, DJ; Sercel, AD; Song, Y; Sorenson, RJ; Unangst, PC | 1 |
| Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Majima, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Taketani, Y; Yamamoto, K; Yamamoto, S | 1 |
| Chinery, R; Coffey, RJ; Damstrup, L; Daniel, VC; Dempsey, PJ; DuBois, RN; Graves-Deal, R; Hawkey, CJ; Jetton, TL; Kirkland, SC; Morrow, JD | 1 |
| Folco, GC | 1 |
| Kaminski, DL; Longo, WE; Mazuski, J; Panesar, N | 1 |
| Gilbertsen, R; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B | 1 |
| Kaminski, D; Longo, WE; Mazuski, JE; Panesar, N | 1 |
| Oh-ishi, S | 1 |
| DuBois, RN; Zhang, Z | 1 |
| Drenan, RM; Gabot, K; Gregorian, C; Insel, PA; Ostrom, RS; Rana, BK | 1 |
| Lozano, JJ; Pouplana, R; Ruiz, J | 1 |
| Bozza, PT; Pacheco, P; Weller, PF; Yu, W | 1 |
| Brunette, E; Gendron, TF; Mealing, GA; Morley, P; Nguyen, A; Tauskela, JS | 1 |
| Bagnato, A; Di Castro, V; Natali, PG; Nicotra, MR; Rosanò, L; Spinella, F | 1 |
| Graham, SH; Rose, ME; Wu Chen, R; Zhang, Y | 1 |
| Allen, S; Daugherty, A; Gong, MC; Guo, Z; Pang, H; Smart, E; Su, W | 1 |
| Bernstein, SH; Chiorazzi, N; Felgar, RE; Kaur, K; Phipps, RP; Pollock, SJ; Ryan, EP | 1 |
| Bernard, MP; Phipps, RP | 1 |
2 review(s) available for sc 58125 and n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
| Article | Year |
|---|---|
New NSAIDs and gastroduodenal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Peptic Ulcer; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiophenes | 1996 |
[COX-2].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Sulfonamides | 2000 |
19 other study(ies) available for sc 58125 and n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
| Article | Year |
|---|---|
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Cyclopentanes; Dose-Response Relationship, Drug; Edema; Indomethacin; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sulfonamides; Sulfones | 1995 |
Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Cyclooxygenase Inhibitors; Cyclopentanes; Mice; Rats | 1994 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Humans; Hyperalgesia; Isoenzymes; Male; Membrane Proteins; Mice; Oxazoles; Phenols; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Thiazoles | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Humans; Hyperalgesia; In Vitro Techniques; Isoenzymes; Male; Membrane Proteins; Mice; Phenols; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sheep; Stomach Ulcer; Structure-Activity Relationship; Thiadiazoles | 1999 |
Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Azo Compounds; Blotting, Western; Carrageenan; Cell Count; Cells, Cultured; Coloring Agents; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Excipients; Inflammation; Isoenzymes; Leukocytes; Male; Nitrobenzenes; Pleura; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2; Trypan Blue | 1996 |
Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.
Topics: Amphiregulin; Cell Compartmentation; Cell Nucleus; Cell Polarity; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; EGF Family of Proteins; ErbB Receptors; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Isoenzymes; Membrane Proteins; Mitosis; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; RNA, Neoplasm; Sulfonamides; Sulindac; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1997 |
Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents.
Topics: Calcimycin; Calcium; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Eicosanoids; Epithelial Cells; Humans; Immunoblotting; Interleukin-1; Intestinal Mucosa; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Salicylates; Sulfonamides; Tetradecanoylphorbol Acetate | 1998 |
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Male; Nitrobenzenes; Peroxidase; Peroxidases; Phenols; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles; Trinitrobenzenesulfonic Acid | 1999 |
Synthetic pathways of gallbladder mucosal prostanoids: the role of cyclooxygenase-1 and 2.
Topics: 6-Ketoprostaglandin F1 alpha; Blotting, Western; Cholecystitis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gallbladder; Gallbladder Neoplasms; Humans; Isoenzymes; Lipopolysaccharides; Lysophosphatidylcholines; Male; Membrane Proteins; Middle Aged; Mucous Membrane; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Sulfonamides; Tumor Cells, Cultured | 1999 |
Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Northern; Blotting, Western; Carrier Proteins; Colonic Neoplasms; Cyclooxygenase Inhibitors; DNA Fragmentation; Gene Expression; Humans; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Nitrobenzenes; Protein Kinase C; Pyrazoles; RNA, Messenger; Sulfonamides; Sulindac; Tumor Cells, Cultured | 2000 |
Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Cell Line; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Dogs; Enzyme Inhibitors; Isoenzymes; Molecular Sequence Data; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; RNA, Messenger; Signal Transduction; Sulfonamides | 2001 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Leukocytes; Leukotriene B4; Leukotrienes; Lipid Metabolism; Mice; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.
Topics: Animals; Calcium; Canada; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Extracellular Space; Glucose Metabolism Disorders; Glutamates; Hypoxia; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Time Factors | 2004 |
Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.
Topics: Animals; Atrasentan; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Isoenzymes; Luciferases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Nude; Nitrobenzenes; Ovarian Neoplasms; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrrolidines; Receptor, Endothelin A; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2004 |
Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.
Topics: Animals; Cell Survival; Cells, Cultured; Cyclin D1; Cyclooxygenase 2; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; Nitrobenzenes; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2004 |
COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice.
Topics: Animals; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Female; Gene Expression Profiling; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Nitrobenzenes; Oligonucleotide Array Sequence Analysis; Point Mutation; Pyrazoles; Receptors, Cell Surface; Receptors, Leptin; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Up-Regulation | 2005 |
Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.
Topics: B-Lymphocytes; Cell Growth Processes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Enzyme Activation; Humans; Immunoglobulin Heavy Chains; Immunohistochemistry; Indomethacin; Isoxazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Nitrobenzenes; Pyrazoles; Sulfonamides; Sulfones; Thromboxane A2 | 2006 |
Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation.
Topics: ADP-ribosyl Cyclase 1; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Contraindications; Cyclooxygenase Inhibitors; Humans; Immunoglobulin Isotypes; Infection Control; Nitrobenzenes; Positive Regulatory Domain I-Binding Factor 1; Pyrazoles; Repressor Proteins; Sulfonamides; Vaccines | 2010 |