sc 51089 has been researched along with dinoprostone in 23 studies
| Studies (sc 51089) | Trials (sc 51089) | Recent Studies (post-2010) (sc 51089) | Studies (dinoprostone) | Trials (dinoprostone) | Recent Studies (post-2010) (dinoprostone) |
|---|---|---|---|---|---|
| 41 | 1 | 19 | 29,105 | 1,346 | 6,357 |
| Protein | Taxonomy | sc 51089 (IC50) | dinoprostone (IC50) |
|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | 0.0155 | |
| Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | 0.0031 | |
| Prostaglandin E2 receptor EP4 subtype | Rattus norvegicus (Norway rat) | 0.0021 | |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | 0.002 | |
| Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | 0.0087 | |
| Prostacyclin receptor | Homo sapiens (human) | 0.26 | |
| Prostaglandin E2 receptor EP2 subtype | Rattus norvegicus (Norway rat) | 0.0052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Green, PG; Ho, T; Khasar, SG; Levine, JD | 1 |
| Beck, D; Cavalier, R; Herin, M; Lee, K; Lesne, M; Li, A; Roba, J; Vandenberghe, Y; Verbeke, N | 1 |
| Hagen, TJ; Hallinan, EA; Husa, RK; Lee, AC; Savage, MA; Stapelfeld, A; Tsymbalov, S | 1 |
| Kato, S; Takeuchi, K; Ukawa, H; Yagi, K | 1 |
| Hosoda, Y; Iwanaga, T; Kuwahara, A; Winarto, A | 1 |
| Maruyama, T; Ohuchida, S | 1 |
| Glaser, S; Hennerbichler, S; Juan, H; Sametz, W; Wintersteiger, R | 1 |
| Hagen, TJ; Hallinan, EA; Savage, MA; Stapelfeld, A; Tsymbalov, S | 1 |
| Heinemann, A; Holzer, P; Peskar, BA; Shahbazian, A | 1 |
| Hamasaki, Y; Ishii, K; Matsuo, M; Yoshida, N; Zaitsu, M | 1 |
| Matlhagela, K; Taub, M | 1 |
| Chou, T; Iadecola, C; Qian, L; Zhou, P | 1 |
| Abe, T; Anrather, J; Iadecola, C; Kunz, A; Shimamura, M; Zhou, P | 1 |
| Black, JD; Carlson, NG; Hill, KE; Hille, J; Redd, JW; Rojas, MA; Rose, JW | 1 |
| Fischborn, SV; Potschka, H; Soerensen, J | 1 |
| Anacker, C; Andreasson, K; Suarez-Mier, GB; Taniguchi, H; Wang, Q | 1 |
| Liu, ML; Liu, X; Pei, LC; Zhang, YN; Zhang, YQ | 1 |
| Anrather, J; Burmeister, MA; Cao, X; Davisson, RL; Guruju, MR; Iadecola, C; Peterson, JR; Wang, G; Young, CN | 1 |
| Keene, CD; Li, X; Montine, KS; Montine, TJ; Rose, SE | 1 |
| Anrather, J; Capone, C; Casolla, B; Iadecola, C; Kurinami, H; Qian, L; Shimamura, M; Zhou, P | 1 |
| Amadio, P; Amato, M; Baldassarre, D; Barbieri, SS; Gianellini, S; Squellerio, I; Tarantino, E; Tremoli, E; Weksler, BB; Zacchi, E | 1 |
| Chiaia, N; Collins, SA; Gudelsky, GA; Huff, C; Yamamoto, BK | 1 |
| Liu, W; Ma, N; Niu, JC; Wang, PJ | 1 |
2 review(s) available for sc 51089 and dinoprostone
| Article | Year |
|---|---|
[Selective agonists and antagonists for prostaglandin E2 receptor subtypes].
Topics: Acetates; Animals; Benzhydryl Compounds; Biphenyl Compounds; Dinoprostone; Drug Design; Humans; Hydrazines; Oxazepines; Receptors, Prostaglandin E | 2000 |
Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro.
Topics: Amyloid beta-Peptides; Animals; Blotting, Western; Calcium Channel Blockers; Cell Line, Tumor; Cells, Cultured; Coloring Agents; Dinoprostone; Humans; Hydrazines; Mice; Mice, Inbred C57BL; Neurons; Neurotoxicity Syndromes; Nimodipine; Oxazepines; Peptide Fragments; Prostaglandin Antagonists; Receptors, Prostaglandin E, EP1 Subtype; Tetrazolium Salts; Thiazoles | 2013 |
1 trial(s) available for sc 51089 and dinoprostone
| Article | Year |
|---|---|
Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells.
Topics: Adult; Aged; Aged, 80 and over; Animals; Dinoprostone; Endothelial Cells; Female; Gene Expression Regulation; Humans; Hydrazines; Interleukin-1beta; Male; Mice; Middle Aged; Myocardium; Oxazepines; Sirtuin 1; Smoking; Thromboplastin; Thrombosis; Xanthones | 2015 |
20 other study(ies) available for sc 51089 and dinoprostone
| Article | Year |
|---|---|
Comparison of prostaglandin E1- and prostaglandin E2-induced hyperalgesia in the rat.
Topics: Alprostadil; Analgesics; Animals; Diabetes Mellitus, Experimental; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hindlimb; Hydrazines; Hyperalgesia; Male; Oxazepines; Pain; Rats; Rats, Sprague-Dawley | 1994 |
Comparative metabolism of SC-42867 and SC-51089, two PGE2 antagonists, in rat and human hepatocyte cultures.
Topics: Adult; Analgesics; Animals; Carbon Radioisotopes; Cells, Cultured; Dinoprostone; Humans; Hydrazines; Liver; Male; Oxazepines; Rats; Rats, Sprague-Dawley | 1994 |
Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs.
Topics: Analgesics; Animals; Cells, Cultured; Dinoprostone; Guinea Pigs; Hydrazines; Ileum; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Oxazepines; Prostaglandin Antagonists; Rats | 1996 |
Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicarbonates; Calcium; Dinoprostone; Duodenum; Gastric Mucosa; Hydrazines; Male; Oxazepines; Prostaglandins E; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Verapamil | 1997 |
Mode of action of ANG II on ion transport in guinea pig distal colon.
Topics: Angiotensin II; Animals; Atropine; Biological Transport; Bumetanide; Chlorides; Colon; Dinoprostone; Electric Conductivity; Guinea Pigs; Hydrazines; Immunohistochemistry; Ions; Male; Neurokinin-1 Receptor Antagonists; Oxazepines; Prostaglandin Antagonists; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrodotoxin | 2000 |
Characterization of prostanoid receptors mediating actions of the isoprostanes, 8-iso-PGE(2) and 8-iso-PGF(2alpha), in some isolated smooth muscle preparations.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Dinoprost; Dinoprostone; Dioxanes; Dose-Response Relationship, Drug; F2-Isoprostanes; Fatty Acids, Unsaturated; Female; Gastric Fundus; Guinea Pigs; Hydrazines; Ileum; In Vitro Techniques; Isoprostanes; Muscle Contraction; Muscle, Smooth; Oxazepines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Thromboxane; Vasoconstriction; Vasoconstrictor Agents | 2000 |
2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.
Topics: Dinoprostone; Hydrazines; Oxazepines; Oxazoles; Thiazoles | 2001 |
Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Female; Guinea Pigs; Hydantoins; Hydrazines; Iloprost; In Vitro Techniques; Intestine, Small; Leukotriene Antagonists; Leukotriene D4; Male; Oxazepines; Peristalsis; Prostaglandin D2; Prostaglandins A; Receptors, Leukotriene; Receptors, Prostaglandin; Xanthenes; Xanthones; Yohimbine | 2002 |
Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089.
Topics: Animals; Brain Neoplasms; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Glioma; Humans; Hydrazines; Isoenzymes; Membrane Proteins; Mice; Mice, SCID; Nitrobenzenes; Oxazepines; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Sulfonamides; Transplantation, Heterologous; Tumor Cells, Cultured; Xanthones | 2004 |
Involvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells.
Topics: Alprostadil; Animals; Cell Line; Dinoprostone; Dogs; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hydrazines; Ion Transport; Kidney Tubules, Distal; Oxazepines; Prostaglandin Antagonists; Protein Kinase C; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sodium-Potassium-Exchanging ATPase; Xanthones | 2006 |
Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway.
Topics: Animals; Cell Survival; Dinoprostone; Hippocampus; Hydrazines; Mice; Neuroprotective Agents; Organ Culture Techniques; Oxazepines; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Signal Transduction | 2008 |
The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic.
Topics: Animals; Body Weight; Brain Ischemia; Dinoprostone; Dose-Response Relationship, Drug; Female; Hydrazines; Male; Mice; Neuroprotective Agents; Oxazepines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Sex Characteristics; Time Factors; Treatment Outcome | 2009 |
Microglial inhibition of neuroprotection by antagonists of the EP1 prostaglandin E2 receptor.
Topics: Animals; Astrocytes; Bridged Bicyclo Compounds; Caproates; Cell Death; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hydrazines; Mice; Microglia; Microscopy, Confocal; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxazepines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 2009 |
Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice.
Topics: Amygdala; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Hydrazines; Kindling, Neurologic; Male; Mice; Oxazepines; Receptors, Prostaglandin E, EP1 Subtype | 2010 |
Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dinoprostone; Endothelial Cells; Glucose; Hippocampus; Hydrazines; Hypoxia-Ischemia, Brain; Misoprostol; Neurons; Oxazepines; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction | 2011 |
Prostaglandin E2 receptor 1 activity regulates cell survival following hypoxia in cultured rat cortical neurons.
Topics: Analysis of Variance; Animals; Annexin A5; Caspase 3; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclin D1; Dinoprostone; Dose-Response Relationship, Drug; Embryo, Mammalian; Hydrazines; Hypoxia; Neurons; Oxazepines; Oxygen; Rats; Rats, Wistar; Receptors, Prostaglandin E, EP1 Subtype; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2012 |
Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain.
Topics: Angiotensin II; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Hydrazines; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazepines; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Prostaglandin E, EP1 Subtype; Signal Transduction; Subfornical Organ | 2012 |
Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; CA1 Region, Hippocampal; Calcineurin; Calcineurin Inhibitors; Caspase 3; Dinoprostone; Hydrazines; Immunohistochemistry; Ischemic Attack, Transient; Mice; Mice, Inbred C57BL; Neurons; Oncogene Protein v-akt; Oxazepines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Transport; Receptors, Prostaglandin E, EP1 Subtype | 2013 |
3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling.
Topics: Animals; Central Nervous System Stimulants; Dentate Gyrus; Dinoprostone; Glutamic Acid; Hippocampus; Hydrazines; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Oxazepines; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Signal Transduction | 2016 |
EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dinoprostone; Gene Silencing; Humans; Hydrazines; Mice; Mice, Nude; Osteosarcoma; Oxazepines; Receptors, Prostaglandin E, EP1 Subtype; Xenograft Model Antitumor Assays | 2019 |