sc-45647 and sucrose-octaacetate

sc-45647 has been researched along with sucrose-octaacetate* in 1 studies

Other Studies

1 other study(ies) available for sc-45647 and sucrose-octaacetate

Article	Year
Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium. Biochemical and biophysical research communications, 2011, Dec-16, Volume: 416, Issue:3-4 The extracellular Ca(2+)-sensing receptor (CASR) is a promiscuous G-protein-coupled receptor closely related to the taste receptors T1R1-T1R3. Here we analyzed the possibility that apart from being stimulated by external Ca(2+) and amino acids, the substances effective as tastants, CASR might serve as a receptor for other sapid compounds. CASR was heterologously expressed in HEK-293 cells, and their responsivity to a variety of bitter and sweet substances was examined. Among them, solely denatonium was found to stimulate Ca(2+) signaling in CASR-positive HEK-293 cells. Apparently, these Ca(2+) responses were specific, as those were inhibited by the CASR antagonist NSP-4123. Altogether, our findings indicate that denatonium stimulates CASR by shifting a dose-response curve for the principal CASR agonist Ca(2+) to lower concentrations. Topics: Aspartame; Cycloheximide; Dipeptides; Guanidines; HEK293 Cells; Humans; Quaternary Ammonium Compounds; Receptors, Calcium-Sensing; Receptors, G-Protein-Coupled; Sucrose; Sweetening Agents	2011

Article

Year

Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium.

Biochemical and biophysical research communications, 2011, Dec-16, Volume: 416, Issue:3-4

The extracellular Ca(2+)-sensing receptor (CASR) is a promiscuous G-protein-coupled receptor closely related to the taste receptors T1R1-T1R3. Here we analyzed the possibility that apart from being stimulated by external Ca(2+) and amino acids, the substances effective as tastants, CASR might serve as a receptor for other sapid compounds. CASR was heterologously expressed in HEK-293 cells, and their responsivity to a variety of bitter and sweet substances was examined. Among them, solely denatonium was found to stimulate Ca(2+) signaling in CASR-positive HEK-293 cells. Apparently, these Ca(2+) responses were specific, as those were inhibited by the CASR antagonist NSP-4123. Altogether, our findings indicate that denatonium stimulates CASR by shifting a dose-response curve for the principal CASR agonist Ca(2+) to lower concentrations.

Topics: Aspartame; Cycloheximide; Dipeptides; Guanidines; HEK293 Cells; Humans; Quaternary Ammonium Compounds; Receptors, Calcium-Sensing; Receptors, G-Protein-Coupled; Sucrose; Sweetening Agents

2011