sc-45647 and neotame

sc-45647 has been researched along with neotame* in 2 studies

Other Studies

2 other study(ies) available for sc-45647 and neotame

ArticleYear
Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium.
    Biochemical and biophysical research communications, 2011, Dec-16, Volume: 416, Issue:3-4

    The extracellular Ca(2+)-sensing receptor (CASR) is a promiscuous G-protein-coupled receptor closely related to the taste receptors T1R1-T1R3. Here we analyzed the possibility that apart from being stimulated by external Ca(2+) and amino acids, the substances effective as tastants, CASR might serve as a receptor for other sapid compounds. CASR was heterologously expressed in HEK-293 cells, and their responsivity to a variety of bitter and sweet substances was examined. Among them, solely denatonium was found to stimulate Ca(2+) signaling in CASR-positive HEK-293 cells. Apparently, these Ca(2+) responses were specific, as those were inhibited by the CASR antagonist NSP-4123. Altogether, our findings indicate that denatonium stimulates CASR by shifting a dose-response curve for the principal CASR agonist Ca(2+) to lower concentrations.

    Topics: Aspartame; Cycloheximide; Dipeptides; Guanidines; HEK293 Cells; Humans; Quaternary Ammonium Compounds; Receptors, Calcium-Sensing; Receptors, G-Protein-Coupled; Sucrose; Sweetening Agents

2011
Active conformations of neotame and other high-potency sweeteners.
    Journal of medicinal chemistry, 2000, Mar-23, Volume: 43, Issue:6

    We carried out extensive conformational analysis of three high-potency sweeteners: neotame, superaspartame, and SC-45647. We then identified six possible pharmacophore features (carboxylate, two hydrophobic groups, and three NH groups) and wrote a computer program to exhaustively compare intramolecular distances among all possible sets of five-point pharmacophores (carboxylate + two hydrophobic groups + two NH groups) for the three compounds. The best pharmacophore model superimposes low-energy conformers of the three compounds in such a way that the five pharmacophore points match well both sterically and with respect to orientation of hydrogen bond donors and acceptors.

    Topics: Dipeptides; Guanidines; Models, Molecular; Molecular Conformation; Software; Sweetening Agents

2000
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