Page last updated: 2024-09-04

sc 4453 and ouabain

sc 4453 has been researched along with ouabain in 4 studies

*Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE. [MeSH]

*Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE. [MeSH]

Compound Research Comparison

Studies
(sc 4453)
Trials
(sc 4453)
Recent Studies (post-2010)
(sc 4453)
Studies
(ouabain)
Trials
(ouabain)
Recent Studies (post-2010) (ouabain)
100016,35772747

Protein Interaction Comparison

ProteinTaxonomysc 4453 (IC50)ouabain (IC50)
STAT3, partialHomo sapiens (human)1.154
Kruppel-like factor 5Homo sapiens (human)0.0832
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Norway rat)4.3
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.17
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.031
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)1.1263
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.1646
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.097
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)6
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)5.8
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)6
Sodium/potassium-transporting ATPase subunit beta-3Rattus norvegicus (Norway rat)0.0018
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0031

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chopra, A; Dudani, AK; Gupta, RS1
Chopra, A; Gupta, RS; Trott, AB1
Chopra, A; Gupta, RS2

Other Studies

4 other study(ies) available for sc 4453 and ouabain

ArticleYear
Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, Volume: 68, Issue:5

    Topics: Animals; Cardiac Glycosides; Cell Line; Cricetinae; Digoxin; Drug Resistance; Gene Amplification; HeLa Cells; Humans; Mutation; Nucleic Acid Hybridization; Ouabain; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Transcription, Genetic

1990
Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants.
    Biochemical pharmacology, 1989, Jul-01, Volume: 38, Issue:13

    Topics: Cardiac Glycosides; Cell Division; Cell Survival; Digoxin; Drug Resistance; HeLa Cells; Humans; Mutation; Ouabain; Structure-Activity Relationship

1989
Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453.
    The Journal of biological chemistry, 1985, Jun-10, Volume: 260, Issue:11

    Topics: Abietanes; Alkaloids; Cardenolides; Cardiac Glycosides; Digoxin; Dose-Response Relationship, Drug; Drug Resistance; HeLa Cells; Humans; Mutation; Ouabain; Rubidium; Sodium-Potassium-Exchanging ATPase

1985
Biochemical and cross-resistance studies with HeLa cell mutants resistant to cardiac glycoside SC4453. Regulation of the resistant form of Na+/K+-ATPase in the mutant cells.
    The Journal of biological chemistry, 1986, Feb-15, Volume: 261, Issue:5

    Topics: Cardiac Glycosides; Digoxin; Drug Resistance; HeLa Cells; Humans; Membrane Proteins; Ouabain; Rubidium; Selection, Genetic; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship

1986