Compounds > sc 4453
Page last updated: 2024-09-04

sc 4453 and digoxin

sc 4453 has been researched along with digoxin in 6 studies

Compound Research Comparison

Studies
(sc 4453)		Trials
(sc 4453)		Recent Studies (post-2010)
(sc 4453)		Studies
(digoxin)		Trials
(digoxin)		Recent Studies (post-2010) (digoxin)
100011,4839581,289

Protein Interaction Comparison

ProteinTaxonomysc 4453 (IC50)digoxin (IC50)
STAT3, partialHomo sapiens (human)1.862
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)0.32
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)0.0055
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.19
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-1Canis lupus familiaris (dog)0.5
Nuclear receptor ROR-gammaHomo sapiens (human)3.4798
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0055
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.2359

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chopra, A; Dudani, AK; Gupta, RS1
Chopra, A; Gupta, RS; Trott, AB1
Chopra, A; Gupta, RS3
Lesne, M; Randimbivololona, F1

Other Studies

6 other study(ies) available for sc 4453 and digoxin

ArticleYear
Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, Volume: 68, Issue:5

    Topics: Animals; Cardiac Glycosides; Cell Line; Cricetinae; Digoxin; Drug Resistance; Gene Amplification; HeLa Cells; Humans; Mutation; Nucleic Acid Hybridization; Ouabain; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Transcription, Genetic

1990
Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants.
    Biochemical pharmacology, 1989, Jul-01, Volume: 38, Issue:13

    Topics: Cardiac Glycosides; Cell Division; Cell Survival; Digoxin; Drug Resistance; HeLa Cells; Humans; Mutation; Ouabain; Structure-Activity Relationship

1989
Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor.
    Biochemical pharmacology, 1987, Nov-15, Volume: 36, Issue:22

    Topics: Cardiac Glycosides; Cell Division; Digitoxin; Digoxin; Drug Resistance; HeLa Cells; Humans; Mutation; Receptors, Drug; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship

1987
Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453.
    The Journal of biological chemistry, 1985, Jun-10, Volume: 260, Issue:11

    Topics: Abietanes; Alkaloids; Cardenolides; Cardiac Glycosides; Digoxin; Dose-Response Relationship, Drug; Drug Resistance; HeLa Cells; Humans; Mutation; Ouabain; Rubidium; Sodium-Potassium-Exchanging ATPase

1985
Biochemical and cross-resistance studies with HeLa cell mutants resistant to cardiac glycoside SC4453. Regulation of the resistant form of Na+/K+-ATPase in the mutant cells.
    The Journal of biological chemistry, 1986, Feb-15, Volume: 261, Issue:5

    Topics: Cardiac Glycosides; Digoxin; Drug Resistance; HeLa Cells; Humans; Membrane Proteins; Ouabain; Rubidium; Selection, Genetic; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship

1986
Intestinal absorption of SC4453 in the guinea-pig.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 260, Issue:2

    Topics: Animals; Cardiac Glycosides; Digoxin; Guinea Pigs; Intestinal Absorption; Intubation, Gastrointestinal; Time Factors

1982