sc 41930 has been researched along with leukotriene b4 in 38 studies
| Studies (sc 41930) | Trials (sc 41930) | Recent Studies (post-2010) (sc 41930) | Studies (leukotriene b4) | Trials (leukotriene b4) | Recent Studies (post-2010) (leukotriene b4) |
|---|---|---|---|---|---|
| 54 | 0 | 0 | 5,886 | 232 | 717 |
| Protein | Taxonomy | sc 41930 (IC50) | leukotriene b4 (IC50) |
|---|---|---|---|
| Leukotriene B4 receptor 1 | Homo sapiens (human) | 0.0019 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 35 (92.11) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bach, NJ; Baker, SR; Baldwin, RF; Borromeo, PS; Cockerham, SL; Fleisch, JH; Floreancig, P; Froelich, LL; Jackson, WT; Sawyer, JS | 1 |
| Fretland, DJ; Gaginella, TS; Kachur, JF; Keith, RH; Kocan, G; Tsai, BS; Villani-Price, D; Walsh, RE; Yang, DC | 1 |
| Grisham, MB; Keenan, CM; Vaananen, PM; Wallace, JL | 1 |
| Herron, DK; Marder, P; Schultz, RM; Sofia, MJ; Spaethe, SM | 2 |
| Lau, AS; Mack, DR; Sherman, PM | 1 |
| Heckenberger, R; Schrör, K | 1 |
| Anglin, CP; Djuric, SW; Fretland, DJ; Widomski, DL; Yu, S | 1 |
| Gaginella, TS; Granger, DN; Zimmerman, BJ | 1 |
| McCafferty, DM; Rioux, KJ; Wallace, JL | 1 |
| Bienvenu, K; Granger, DN; Russell, J | 1 |
| Kemény, L; Ruzicka, T | 1 |
| Anglin, CP; Fretland, DJ; Gaginella, TS; Widomski, DL | 1 |
| Gaginella, TS; Granger, DN; Grisham, MB; Guillory, DJ; Zimmerman, BJ | 1 |
| Djuric, SW; Fretland, DJ; Gaginella, TS; Levin, S; Shone, RL; Tsai, BS; Widomski, D; Zemaitis, JM | 1 |
| Butchko, GM; Collins, PW; Djuric, SW; Fretland, DJ; Jones, PH; Keith, RH; Shone, RL; Tsai, BS; Villani-Price, D; Zemaitis, JM | 1 |
| Bauer, RF; Djuric, SW; Keith, RH; Leonard, R; Shone, RL; Tsai, BS; Villani-Price, D; Zemaitis, JM | 1 |
| Anglin, CP; Bremer, M; Djuric, SW; Docter, SH; Fretland, DJ; Isakson, P; Paulson, SK; Penning, TD; Widomski, DL; Yu, S | 1 |
| Chiao, JJ; Davis, JM; Fantini, GA; Fyfe, BS; Hoffman, LA; Kirschner, RE | 2 |
| Froelich, LL; Mann, LL; Marder, P; Sawyer, JS; Spaethe, SM | 1 |
| Pettipher, ER; Salter, ED; Showell, HJ | 1 |
| Djuric, SW; Isakson, PC; Rao, TS; Yu, SS | 1 |
| Gough, MJ; Homer-Vanniasinkam, S | 1 |
| Bahl, AK; Clayton, NM; Harman, IW; Strong, P; Trevethick, MA | 1 |
| Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF | 1 |
| Anglin, CP; Djuric, SW; Docter, SH; Fretland, DJ; Kachur, JF; Keith, RH; Penning, TD; Spangler, D; Tsai, BS; Yu, SS | 1 |
| Carson, R; Clapp, N; Fretland, D; Hansard, R; Henke, M | 1 |
| Anglin, C; Carson, R; Clapp, N; Fretland, D; Hansard, R; Henke, M; Walsh, R; Widomski, D | 1 |
| Jamieson, D; Lin, Y | 1 |
| Anglin, CP; Djuric, SW; Fretland, DJ; Penning, TD; Widomski, DL; Yu, S | 1 |
| Arndt, H; Granger, DN; Kubes, P; Kurose, I; Russell, JB | 1 |
| Kararli, TT; Kirchhoff, CF; Truelove, JE | 1 |
| Bortuzzo, C; Hanif, R; Kashfi, K; Rigas, B; Shiff, SJ; Staiano-Coico, L | 1 |
| Baker, SR; Bendele, AM; Cockerham, SL; Froelich, LL; Jackson, WT; Rippy, MK; Silbaugh, SA; Sofia, MJ; Stengel, PW | 1 |
| Balsitis, M; Cole, AT; Hawkey, CJ; McLaughlan, J; Pilkington, BJ; Smith, C | 1 |
| Godfrey, HP; Lin, KT; Wong, PY | 1 |
| Bendele, AM; Cockerham, SL; Froelich, LL; Jackson, WT; Sawyer, JS; Silbaugh, SA; Sofia, MJ; Spaethe, SM; Stengel, PW | 1 |
38 other study(ies) available for sc 41930 and leukotriene b4
| Article | Year |
|---|---|
Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Topics: Airway Obstruction; Animals; Benzoates; Guinea Pigs; Humans; Leukotriene B4; Lung; Neutrophils; Phenols; Receptors, Leukotriene B4; Structure-Activity Relationship; Tetrazoles | 1995 |
Multiple actions of the leukotriene B4 receptor antagonist SC-41930.
Topics: Animals; Benzopyrans; Dinoprostone; Eicosanoids; Epoxide Hydrolases; Guinea Pigs; Humans; Leukemia, Experimental; Leukemia, Myeloid; Leukotriene B4; Neutrophils; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Receptors, Immunologic; Receptors, Leukotriene B4; Skin; Superoxides; Tumor Cells, Cultured | 1992 |
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzopyrans; Carrier Proteins; Free Radical Scavengers; Gastric Mucosa; Hydroxyurea; Indoles; Indomethacin; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Proteins; Organic Chemicals; Permeability; Phenylcarbamates; Propionates; Quinolines; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; Receptors, Leukotriene B4; Single-Blind Method; Stomach Ulcer; Sulfonamides; Tetrazoles; Tosyl Compounds | 1992 |
Flow cytometric evaluation of the effects of leukotriene B4 receptor antagonists (LY255283 and SC-41930) on calcium mobilization and integrin expression of activated human neutrophils.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Integrins; Leukotriene B4; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Tetrazoles; Up-Regulation | 1992 |
Systemic tumor necrosis factor-alpha production in experimental colitis.
Topics: Animals; Benzopyrans; Cells, Cultured; Colitis, Ulcerative; Dinitrochlorobenzene; Disease Models, Animal; Escherichia coli; Leukocytes, Mononuclear; Leukotriene B4; Lipopolysaccharides; Rabbits; Receptors, Immunologic; Receptors, Leukotriene B4; Tumor Necrosis Factor-alpha | 1992 |
Inhibition of calcimycin-induced stimulation of cytosolic calcium in human PMN by a LTB4 receptor antagonist.
Topics: Arachidonate 5-Lipoxygenase; Benzopyrans; Calcimycin; Calcium; Cytosol; Humans; Leukotriene B4; Neutrophils; Platelet Activating Factor; Receptors, Immunologic; Receptors, Leukotriene B4 | 1992 |
Optical isomers of a leukotriene B4 antagonist have differential effects on granulocyte diapedesis in the guinea pig dermis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Chemotaxis, Leukocyte; Granulocytes; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Male; Skin; Stereoisomerism | 1992 |
Effects of SC-41930 on leukocyte adherence and emigration in rat mesenteric venules.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Cell Adhesion; Cell Movement; Leukocytes; Leukotriene B4; Male; Mesenteric Veins; Rats; Rats, Sprague-Dawley; Venules | 1992 |
Granulocyte infiltration in experimental colitis in the rat is interleukin-1 dependent and leukotriene independent.
Topics: Analysis of Variance; Animals; Benzopyrans; Chemotaxis, Leukocyte; Colitis; Interleukin-1; Kinetics; Leukotriene B4; Male; Neutrophils; Peroxidase; Quinolines; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1992 |
Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules.
Topics: Animals; Antigens, CD; Azepines; Benzopyrans; Cats; CD18 Antigens; Endothelium, Vascular; Indoles; Leukocytes; Leukotriene B4; Mesenteric Veins; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Triazoles; Venules | 1992 |
SC-41930, a leukotriene B4 receptor antagonist, inhibits 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) binding to epidermal cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Benzopyrans; Carcinoma, Squamous Cell; Epidermis; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Tumor Cells, Cultured | 1991 |
Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production.
Topics: Adult; Benzopyrans; Cell Adhesion; Humans; In Vitro Techniques; Leukotriene B4; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Superoxides; Tetrazoles | 1991 |
The antiinflammatory agent SC-41930 inhibits granulocyte infiltration of the rodent dermis induced by 6-trans-leukotriene B4.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Biomarkers; Chemotaxis, Leukocyte; Granulocytes; Guinea Pigs; Injections, Intradermal; Leukotriene B4; Male; Mice; Peroxidase; Skin | 1991 |
Role of leukotriene B4 in granulocyte infiltration into the postischemic feline intestine.
Topics: Analysis of Variance; Animals; Benzopyrans; Cats; Granulocytes; Indoles; Intestinal Mucosa; Ischemia; Leukotriene B4; Masoprocol; Radioimmunoassay; Reperfusion Injury | 1990 |
Effect of the leukotriene B4 receptor antagonist SC-41930 on colonic inflammation in rat, guinea pig and rabbit.
Topics: Animals; Benzopyrans; Capillary Permeability; Colitis; Dose-Response Relationship, Drug; Guinea Pigs; Leukotriene B4; Male; Neutrophils; Peroxidase; Rabbits; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene B4 | 1990 |
7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist.
Topics: Animals; Benzopyrans; Chemical Phenomena; Chemistry; Chemotaxis, Leukocyte; Colitis; Cytoplasmic Granules; Guinea Pigs; Humans; Leukotriene B4; Molecular Structure; Neutrophils; Peroxidase; Receptors, Immunologic; Receptors, Leukotriene B4 | 1989 |
SC-41930: an inhibitor of leukotriene B4-stimulated human neutrophil functions.
Topics: Benzopyrans; Binding, Competitive; Chemotaxis, Leukocyte; Complement C5a; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tritium | 1989 |
Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: impact upon leukotriene B4- and 12(R)-HETE-mediated events.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Benzopyrans; Biomarkers; Chemotaxis, Leukocyte; Granulocytes; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Injections, Intradermal; Leukotriene B4; Male; Membrane Potentials; Neutrophils; Peroxidase; Receptors, Leukotriene B4; Skin | 1995 |
Neutrophil lipoxygenase activation and leukosequestration in postischemic myocutaneous flaps: role of LTB4.
Topics: Animals; Arachidonate 5-Lipoxygenase; Benzopyrans; Blood Pressure; Enzyme Activation; Female; Heart Rate; Ischemia; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Muscle, Skeletal; Neutrophils; Receptors, Leukotriene B4; Reperfusion; Skin; Surgical Flaps; Swine | 1995 |
Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist.
Topics: Benzoates; Benzopyrans; Binding, Competitive; Calcium; CD11 Antigens; Dose-Response Relationship, Drug; Humans; Leukotriene B4; Neutrophil Activation; Neutrophils; Receptors, Leukotriene B4; Up-Regulation | 1995 |
Effect of in vivo desensitization to leukotriene B4 on eosinophil infiltration in response to C5a in guinea-pig skin.
Topics: Amitrole; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Complement C5a; Eosinophils; Guinea Pigs; In Vitro Techniques; Inflammation Mediators; Leukotriene B4; Male; Neutrophils; Peroxidases; Platelet Activating Factor; Recombinant Proteins; Skin | 1994 |
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzamides; Benzopyrans; Dermatitis, Contact; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Receptors, Leukotriene B4; Tetradecanoylphorbol Acetate | 1994 |
Role of lipid mediators in the pathogenesis of skeletal muscle infarction and oedema during reperfusion after ischaemia.
Topics: Animals; Benzopyrans; Biphenyl Compounds; Edema; Heptanoic Acids; Infarction; Ischemia; Leukotriene B4; Lipid Peroxides; Male; Muscle, Skeletal; Pregnatrienes; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Reperfusion Injury | 1994 |
Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the re-fed rat.
Topics: Administration, Oral; Animals; Benzopyrans; Female; Indazoles; Indoles; Indomethacin; Injections, Subcutaneous; Leukotriene Antagonists; Leukotriene B4; Microscopy, Electron; Pyloric Antrum; Rats; SRS-A; Stomach Ulcer | 1994 |
In vivo characterization of zymosan-induced mouse peritoneal inflammation.
Topics: Acetophenones; Animals; Arachidonate 5-Lipoxygenase; Benzopyrans; Complement C5a; Leukotriene B4; Male; Mast Cells; Mice; Peritonitis; Peroxidase; Tetrazoles; Zymosan | 1994 |
The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930.
Topics: Animals; Benzopyrans; Binding Sites; Cell Degranulation; Chemotaxis, Leukocyte; Colitis; Dermatitis; Disease Models, Animal; Drug Design; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Mice; Receptors, Leukotriene B4; Thiazoles | 1993 |
Anti-colitic efficacy of SC-41930 in colitic cotton-top tamarins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Body Weight; Colitis; Colon; Disease Models, Animal; Leukotriene B4; Saguinus | 1993 |
Inflammatory mediator changes in cotton-top tamarins (CTT) after SC-41930 anti-colitic therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Benzopyrans; Colitis; Colon; Dinoprostone; Disease Models, Animal; Leukotriene B4; Platelet Activating Factor; Radioimmunoassay; Saguinus; Thromboxane B2 | 1993 |
Are leukotrienes or PAF involved in hyperbaric oxygen toxicity?
Topics: Animals; Benzopyrans; Female; Furans; Indoles; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Oxygen; Platelet Activating Factor; Pressure; Propionates; Quinolines; Rats; Seizures; Specific Pathogen-Free Organisms; SRS-A | 1993 |
Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146.
Topics: Administration, Oral; Animals; Benzamides; Benzopyrans; Chemotaxis, Leukocyte; Granulocytes; Guinea Pigs; Injections, Intradermal; Leukotriene B4; Male; Peroxidase; Receptors, Immunologic; Receptors, Leukotriene B4; Skin; Thiazoles | 1993 |
Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Azepines; Benzopyrans; Blood Pressure; Cell Adhesion; Cell Communication; Cell Movement; Leukocytes; Leukotriene B4; Mesenteric Veins; Microscopy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinacrine; Rats; Rats, Inbred WKY; Regional Blood Flow; Triazoles; Venules | 1993 |
Ionic strength dependence of dissolution for Eudragit S-100 coated pellets.
Topics: Acrylic Resins; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bromcresol Green; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Leukotriene B4; Osmolar Concentration; Particle Size; Polymethacrylic Acids; Solubility; Tablets, Enteric-Coated | 1995 |
The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Benzopyrans; Cell Division; Colonic Neoplasms; Eicosanoids; Flow Cytometry; Humans; Hydroxyeicosatetraenoic Acids; Interphase; Leukotriene B4; Mitosis; Receptors, Leukotriene; S Phase; Tumor Cells, Cultured | 1996 |
Aerosolized LTB4 produces delayed onset increases in pulmonary gas trapping.
Topics: Aerosols; Airway Obstruction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchoalveolar Lavage; Cyclooxygenase Inhibitors; Granulocytes; Guinea Pigs; Inflammation; Leukotriene B4; Lung; Lung Volume Measurements; Male; Microscopy; Receptors, Leukotriene B4; Stereoisomerism | 1996 |
Mucosal factors inducing neutrophil movement in ulcerative colitis: the role of interleukin 8 and leukotriene B4.
Topics: Adult; Aged; Aged, 80 and over; Benzopyrans; Case-Control Studies; Cell Movement; Colitis, Ulcerative; Female; Globulins; Humans; Interleukin-8; Intestinal Mucosa; Leukotriene B4; Male; Middle Aged; Neutrophils; Radioimmunoassay | 1996 |
Ischemia-reperfusion injury in myocutaneous flaps: role of leukocytes and leukotrienes.
Topics: Animals; Benzopyrans; Diethylcarbamazine; Female; Inflammation Mediators; Leukotriene B4; Lipoxygenase Inhibitors; Muscle, Skeletal; Necrosis; Neutrophils; Receptors, Leukotriene B4; Reperfusion Injury; Surgical Flaps; Swine | 1997 |
LTB4 receptor antagonists exacerbate T lymphocyte-mediated delayed hypersensitivity in guinea pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Female; Freund's Adjuvant; Guinea Pigs; Hypersensitivity, Delayed; Leukotriene B4; Male; Mycobacterium tuberculosis; Radioligand Assay; Receptors, Leukotriene B4; Skin Tests; T-Lymphocytes; Tritium | 1997 |
Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: in vivo pulmonary studies.
Topics: Airway Obstruction; Animals; Benzoates; Benzopyrans; Bronchoalveolar Lavage Fluid; Calcimycin; Chemotaxis, Leukocyte; Dinoprostone; Granulocytes; Guinea Pigs; Inflammation; Leukotriene Antagonists; Leukotriene B4; Lung; Male; Receptors, Leukotriene B4; Thromboxane B2 | 2000 |