sb-415286 and butenolide

sb-415286 has been researched along with butenolide* in 1 studies

Other Studies

1 other study(ies) available for sb-415286 and butenolide

Article	Year
Eutypoids B-E produced by a Penicillium sp. strain from the North Sea. Journal of natural products, 2011, Jan-28, Volume: 74, Issue:1 Crude extracts of the Penicillium sp. strain KF620 isolated from the North Sea showed antimicrobial activities against Xanthomonas campestris and Candida glabrata. Purification of the extracts led to the isolation of the new aromatic butenolides eutypoids B (1), C (2), D (3), and E (4). Their structures were elucidated by NMR spectroscopy and supported by HRESIMS and UV data. The antibacterial activity of the crude extracts was due to the presence of the known diketopiperazine fellutanine (cyclo(Trp-Trp)). The eutypoids were neither cytotoxic nor antibacterial, but inhibited the activity of glycogen synthase kinase-3β. Topics: 4-Butyrolactone; Aminophenols; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Candida glabrata; Dipeptides; Drug Screening Assays, Antitumor; Glycogen Synthase Kinases; Hep G2 Cells; HT29 Cells; Humans; Maleimides; Mice; Microbial Sensitivity Tests; Molecular Structure; NIH 3T3 Cells; North Sea; Nuclear Magnetic Resonance, Biomolecular; Penicillium; Peptides, Cyclic; Xanthomonas campestris	2011

Article

Year

Eutypoids B-E produced by a Penicillium sp. strain from the North Sea.

Journal of natural products, 2011, Jan-28, Volume: 74, Issue:1

Crude extracts of the Penicillium sp. strain KF620 isolated from the North Sea showed antimicrobial activities against Xanthomonas campestris and Candida glabrata. Purification of the extracts led to the isolation of the new aromatic butenolides eutypoids B (1), C (2), D (3), and E (4). Their structures were elucidated by NMR spectroscopy and supported by HRESIMS and UV data. The antibacterial activity of the crude extracts was due to the presence of the known diketopiperazine fellutanine (cyclo(Trp-Trp)). The eutypoids were neither cytotoxic nor antibacterial, but inhibited the activity of glycogen synthase kinase-3β.

Topics: 4-Butyrolactone; Aminophenols; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Candida glabrata; Dipeptides; Drug Screening Assays, Antitumor; Glycogen Synthase Kinases; Hep G2 Cells; HT29 Cells; Humans; Maleimides; Mice; Microbial Sensitivity Tests; Molecular Structure; NIH 3T3 Cells; North Sea; Nuclear Magnetic Resonance, Biomolecular; Penicillium; Peptides, Cyclic; Xanthomonas campestris

2011