sb-334867-a has been researched along with indole* in 1 studies
1 other study(ies) available for sb-334867-a and indole
Article | Year |
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1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
This communication reports SARs for the first orexin-1 receptor antagonist series of 1-aryl-3-quinolin-4-yl and 1-aryl-3-naphthyridin-4-yl ureas. One of these compounds, 31 (SB-334867), has excellent selectivity for the orexin-1 receptor, blood-brain barrier permeability and shows in vivo activity following ip dosing. Topics: Animals; Benzoxazoles; Blood-Brain Barrier; Central Nervous System; CHO Cells; Cricetinae; Humans; Indoles; Infusions, Intravenous; Naphthyridines; Orexin Receptors; Permeability; Quinolines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sensitivity and Specificity; Structure-Activity Relationship; Urea | 2001 |