sb-290157 and leucyl-alanine

sb-290157 has been researched along with leucyl-alanine* in 1 studies

Other Studies

1 other study(ies) available for sb-290157 and leucyl-alanine

Article	Year
Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships. Bioorganic & medicinal chemistry letters, 2015, Dec-01, Volume: 25, Issue:23 Potent ligands for the human complement C3a receptor (C3aR) were developed from the almost inactive tripeptide Leu-Ala-Arg corresponding to the three C-terminal residues of the endogenous peptide agonist C3a. The analogous Leu-Ser-Arg was modified by condensing the serine side chain with the leucine carbonyl with elimination of water to form leucine-oxazole-arginine. Subsequent elaboration with a variety of N-terminal amide capping groups produced agonists as potent as human C3a itself in stimulating Ca(2+) release from human macrophages. Structure-activity relationships are discussed. Topics: Amino Acids; Arginine; Benzhydryl Compounds; Dipeptides; Dose-Response Relationship, Drug; Humans; Ligands; Macrophages; Molecular Structure; Oxazoles; Receptors, Complement; Structure-Activity Relationship	2015

Article

Year

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

Bioorganic & medicinal chemistry letters, 2015, Dec-01, Volume: 25, Issue:23

Potent ligands for the human complement C3a receptor (C3aR) were developed from the almost inactive tripeptide Leu-Ala-Arg corresponding to the three C-terminal residues of the endogenous peptide agonist C3a. The analogous Leu-Ser-Arg was modified by condensing the serine side chain with the leucine carbonyl with elimination of water to form leucine-oxazole-arginine. Subsequent elaboration with a variety of N-terminal amide capping groups produced agonists as potent as human C3a itself in stimulating Ca(2+) release from human macrophages. Structure-activity relationships are discussed.

Topics: Amino Acids; Arginine; Benzhydryl Compounds; Dipeptides; Dose-Response Relationship, Drug; Humans; Ligands; Macrophages; Molecular Structure; Oxazoles; Receptors, Complement; Structure-Activity Relationship

2015