sb-269970 has been researched along with 2-oxindole* in 1 studies
1 other study(ies) available for sb-269970 and 2-oxindole
Article | Year |
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Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT₇ Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs.
We have investigated several oxindole derivatives in the pursuit of a 5-HT7 receptor PET ligand. Herein the synthesis, chiral separation, and pharmacological profiling of two possible PET candidates toward a wide selection of CNS-targets are detailed. Subsequent (11)C-labeling and in vivo evaluation in Danish landrace pigs showed that both ligands displayed high brain uptake. However, neither of the radioligands could be displaced by the 5-HT7 receptor selective inverse agonist SB-269970. Topics: Animals; Brain; Carbon Radioisotopes; Indoles; Ligands; Oxindoles; Phenols; Positron-Emission Tomography; Receptors, Serotonin; Sulfonamides; Swine | 2015 |