sb-269970 and 2-oxindole

sb-269970 has been researched along with 2-oxindole* in 1 studies

Other Studies

1 other study(ies) available for sb-269970 and 2-oxindole

Article	Year
Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT₇ Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs. Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8 We have investigated several oxindole derivatives in the pursuit of a 5-HT7 receptor PET ligand. Herein the synthesis, chiral separation, and pharmacological profiling of two possible PET candidates toward a wide selection of CNS-targets are detailed. Subsequent (11)C-labeling and in vivo evaluation in Danish landrace pigs showed that both ligands displayed high brain uptake. However, neither of the radioligands could be displaced by the 5-HT7 receptor selective inverse agonist SB-269970. Topics: Animals; Brain; Carbon Radioisotopes; Indoles; Ligands; Oxindoles; Phenols; Positron-Emission Tomography; Receptors, Serotonin; Sulfonamides; Swine	2015

Article

Year

Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT₇ Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs.

Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8

We have investigated several oxindole derivatives in the pursuit of a 5-HT7 receptor PET ligand. Herein the synthesis, chiral separation, and pharmacological profiling of two possible PET candidates toward a wide selection of CNS-targets are detailed. Subsequent (11)C-labeling and in vivo evaluation in Danish landrace pigs showed that both ligands displayed high brain uptake. However, neither of the radioligands could be displaced by the 5-HT7 receptor selective inverse agonist SB-269970.

Topics: Animals; Brain; Carbon Radioisotopes; Indoles; Ligands; Oxindoles; Phenols; Positron-Emission Tomography; Receptors, Serotonin; Sulfonamides; Swine

2015