Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and zm 336372

sb 203580 has been researched along with zm 336372 in 7 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(zm 336372)		Trials
(zm 336372)		Recent Studies (post-2010) (zm 336372)
3,48941,13727011

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)zm 336372 (IC50)
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)100
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.0603
Proto-oncogene tyrosine-protein kinase LCK Mus musculus (house mouse)0.57
Serine/threonine-protein kinase B-rafHomo sapiens (human)0.23
Delta-type opioid receptorMus musculus (house mouse)0.18
Mitogen-activated protein kinase 11Homo sapiens (human)2
Mitogen-activated protein kinase 14Homo sapiens (human)1.09

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's5 (71.43)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Belfield, AJ; Brown, DS; Brown, GR; Campbell, D; Foubister, A; Masters, DJ; Pike, KG; Snelson, WL; Wells, SL1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Chen, YD; Jiao, Y; Li, HF; Lu, T; Wang, X; Zhang, LY; Zhu, T1
Dart, ML; Hartnett, JR; Jost, E; Killoran, MP; Kirkland, TA; Machleidt, T; Robers, MB; Schwinn, MK; Shi, C; Wilkinson, JM; Wood, KV; Zimmerman, K1
Boyle, FT; Cohen, P; Eyers, PA; Goedert, M; Hall-Jackson, CA; Hedge, P; Hewitt, N; Plant, H1

Other Studies

7 other study(ies) available for sb 203580 and zm 336372

ArticleYear
A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: Amides; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Rats; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha

2004
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Pharmacophore identification of Raf-1 kinase inhibitors.
    Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7

    Topics: Binding Sites; Biological Transport; Enzyme Inhibitors; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Biological; Models, Chemical; Proto-Oncogene Proteins c-raf; Structure-Activity Relationship

2008
Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.
    ACS medicinal chemistry letters, 2018, Jun-14, Volume: 9, Issue:6

    Topics:

2018
Paradoxical activation of Raf by a novel Raf inhibitor.
    Chemistry & biology, 1999, Volume: 6, Issue:8

    Topics: 3T3 Cells; Animals; Benzamides; Biotransformation; Blotting, Western; Cell Line; Enzyme Inhibitors; Growth Substances; Guanine Nucleotides; Imidazoles; Isomerism; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phenotype; Phorbol Esters; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogenes; Pyridines

1999